genetic crosses


Top Publications

  1. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
  2. ncbi The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
  3. pmc Permutation tests for multiple loci affecting a quantitative character
    R W Doerge
    Biometrics Unit, Cornell University, Ithaca, New York 14853, USA
    Genetics 142:285-94. 1996
  4. ncbi Map Manager QTX, cross-platform software for genetic mapping
    K F Manly
    Cellular and Molecular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mamm Genome 12:930-2. 2001
  5. ncbi The pseudo-response regulator Ppd-H1 provides adaptation to photoperiod in barley
    Adrian Turner
    Crop Genetics Department, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Science 310:1031-4. 2005
  6. ncbi Genetic dissection of transcriptional regulation in budding yeast
    Rachel B Brem
    Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109, USA and Howard Hughes Medical Institute
    Science 296:752-5. 2002
  7. pmc A single gene causes both male sterility and segregation distortion in Drosophila hybrids
    Nitin Phadnis
    Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
    Science 323:376-9. 2009
  8. ncbi The genetic architecture of divergence between threespine stickleback species
    C L Peichel
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305-5329, USA
    Nature 414:901-5. 2001
  9. pmc The recombinational anatomy of a mouse chromosome
    Kenneth Paigen
    Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 4:e1000119. 2008
  10. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999

Detail Information

Publications298 found, 100 shown here

  1. ncbi R/qtl: QTL mapping in experimental crosses
    Karl W Broman
    Department of Biostatistics, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Bioinformatics 19:889-90. 2003
  2. ncbi The Collaborative Cross, a community resource for the genetic analysis of complex traits
    Gary A Churchill
    The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
    Nat Genet 36:1133-7. 2004
    ..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease...
  3. pmc Permutation tests for multiple loci affecting a quantitative character
    R W Doerge
    Biometrics Unit, Cornell University, Ithaca, New York 14853, USA
    Genetics 142:285-94. 1996
    ..The search space for minor QTL is unrestricted, and RET-based tests may be more powerful than the CET-based test when the structural model is approximately true...
  4. ncbi Map Manager QTX, cross-platform software for genetic mapping
    K F Manly
    Cellular and Molecular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mamm Genome 12:930-2. 2001
    ..which allow it to be compiled for multiple computer platforms. It currently is distributed for Microsoft Windows and Mac OS and is available at
  5. ncbi The pseudo-response regulator Ppd-H1 provides adaptation to photoperiod in barley
    Adrian Turner
    Crop Genetics Department, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Science 310:1031-4. 2005
  6. ncbi Genetic dissection of transcriptional regulation in budding yeast
    Rachel B Brem
    Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109, USA and Howard Hughes Medical Institute
    Science 296:752-5. 2002
    ..We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function...
  7. pmc A single gene causes both male sterility and segregation distortion in Drosophila hybrids
    Nitin Phadnis
    Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
    Science 323:376-9. 2009
    ..This segregation distorter gene is essential for hybrid sterility, a strong reproductive barrier between these young taxa. Our results suggest that genetic conflict may be an important evolutionary force in speciation...
  8. ncbi The genetic architecture of divergence between threespine stickleback species
    C L Peichel
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University, Stanford, California 94305-5329, USA
    Nature 414:901-5. 2001
    ..Further study of these regions will help to define the number and type of genetic changes that underlie morphological diversification during vertebrate evolution...
  9. pmc The recombinational anatomy of a mouse chromosome
    Kenneth Paigen
    Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 4:e1000119. 2008
    ..It appears that the regulation of mammalian recombination is a complex, dynamic process involving multiple factors reflecting species, sex, individual variation within species, and the properties of individual hotspots...
  10. ncbi Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    P Bouillet
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Science 286:1735-8. 1999
    ..Thus, Bim is required for hematopoietic homeostasis and as a barrier to autoimmunity. Moreover, particular death stimuli appear to activate apoptosis through distinct BH3-only proteins...
  11. ncbi Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality
    L E Stephens
    Department of Stomatology, University of California, San Francisco 94143 0512, USA
    Genes Dev 9:1883-95. 1995
  12. pmc A statistical framework for quantitative trait mapping
    S Sen
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genetics 159:371-87. 2001
    ..A software tool implementing this procedure is available. We demonstrate our approach to QTL analysis using data from a mouse backcross population that is segregating multiple interacting QTL associated with salt-induced hypertension...
  13. pmc Multiple interval mapping for quantitative trait loci
    C H Kao
    Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan, Republic of China
    Genetics 152:1203-16. 1999
    ..The MIM FORTRAN program is available on the worldwide web (
  14. ncbi Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation
    X Wu
    Department of Pathology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
    Mech Dev 101:61-9. 2001
    ..The PB-Cre4 mice will be a useful resource for genetic-based studies on prostate development and prostatic disease...
  15. pmc Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
    K Podsypanina
    Departments of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P and S 14 453, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 96:1563-8. 1999
    ..Taken together, these data suggest that PTEN is a regulator of apoptosis and proliferation that behaves as a "landscaper" tumor suppressor in the gut and a "gatekeeper" tumor suppressor in other organs...
  16. ncbi The master sex-determination locus in threespine sticklebacks is on a nascent Y chromosome
    Catherine L Peichel
    Department of Developmental Biology and Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94305, USA
    Curr Biol 14:1416-24. 2004
    ..Here, we investigate the genetic and chromosomal mechanisms that underlie sex determination in the threespine stickleback (Gasterosteus aculeatus)...
  17. ncbi Parent-of-origin effects on seed development in Arabidopsis thaliana
    R J Scott
    Department of Biology, University of Leicester, University Road, Leicester LE1 7RH, UK
    Development 125:3329-41. 1998
    ..One explanation of our observations is that seeds with maternal or paternal excess contain different doses of maternally or paternally expressed imprinted loci affecting endosperm development...
  18. pmc Using progenitor strain information to identify quantitative trait nucleotides in outbred mice
    B Yalcin
    Wellcome Trust Centre for Human Genetics, Oxford University, UK
    Genetics 171:673-81. 2005
  19. ncbi Genetics of gene expression surveyed in maize, mouse and man
    Eric E Schadt
    Rosetta Inpharmatics, LLC, 12040 115th Avenue N E, Kirkland, Washington 98034, USA
    Nature 422:297-302. 2003
    ..We identify a gene expression pattern strongly associated with obesity in a murine cross, and observe two distinct obesity subtypes. Furthermore, we find that these obesity subtypes are under the control of different loci...
  20. ncbi The hidden side of invasions: massive introgression by local genes
    Mathias Currat
    Computational and Molecular Population Genetics Laboratory, Institute of Zoology, University of Bern, Baltzerstrasse 6, 3012 Berne, Switzerland
    Evolution 62:1908-20. 2008
    ..Our results imply that speciation genes can be identified by comparing genomes of interfertile native and invading species pairs...
  21. pmc Diversity Arrays Technology (DArT) for whole-genome profiling of barley
    Peter Wenzl
    Center for the Application of Molecular Biology to International Agriculture, G P O Box 3200, Canberra, ACT 2601, Australia
    Proc Natl Acad Sci U S A 101:9915-20. 2004
    ..These results highlight the potential of DArT as a generic technique for genome profiling in the context of molecular breeding and genomics...
  22. pmc Integrating genetic and network analysis to characterize genes related to mouse weight
    Anatole Ghazalpour
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 2:e130. 2006
    ..Our approach results in the identification of genetic targets that influence gene modules (pathways) that are related to the clinical phenotypes of interest...
  23. ncbi Powdery mildew resistance and Lr34/Yr18 genes for durable resistance to leaf and stripe rust cosegregate at a locus on the short arm of chromosome 7D of wheat
    W Spielmeyer
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
    Theor Appl Genet 111:731-5. 2005
    ..The Lr34/Yr18 phenotypes and associated powdery mildew resistance were mapped to a single locus flanked by microsatellite loci Xgwm1220 and Xgwm295 on chromosome 7DS...
  24. pmc Comparative recombination rates in the rat, mouse, and human genomes
    Michael I Jensen-Seaman
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 14:528-38. 2004
    ..This comparative approach provides additional insight into the causes and consequences of genomic heterogeneity in recombination...
  25. pmc Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genetics 172:1783-97. 2006
    ..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
  26. pmc Poor performance of bootstrap confidence intervals for the location of a quantitative trait locus
    Ani Manichaikul
    Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205 2179, USA
    Genetics 174:481-9. 2006
    ..Likelihood support intervals and approximate Bayes credible intervals, on the other hand, are shown to behave appropriately...
  27. ncbi Model for mapping imprinted quantitative trait loci in an inbred F2 design
    Yuehua Cui
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genomics 87:543-51. 2006
    ..Our approach provides a standard procedure for testing the statistical significance of iQTL involved in the genetic control of complex traits...
  28. ncbi Two meiotic crossover classes cohabit in Arabidopsis: one is dependent on MER3,whereas the other one is not
    Raphael Mercier
    Station de Genetique et d Amelioration des plantes, Institut National de la Recherche Agronomique, Versailles, France
    Curr Biol 15:692-701. 2005
    ..The situation in mammals and plants remains unclear. Mer3 is one of the genes shown to be required for the formation of interference-sensitive crossovers in Saccharomyces cerevisiae...
  29. pmc The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics
    Elissa J Chesler
    Systems Genetics Group, Biosciences Division, Oak Ridge National Laboratory, Bldg 1059 MS 6420, P O Box 2008, Oak Ridge, TN 37831 6420, USA
    Mamm Genome 19:382-9. 2008
    ..Herein we present a progress report of the Collaborative Cross breeding program at ORNL and a description of the kinds of investigations that this resource will support...
  30. ncbi MCQTL: multi-allelic QTL mapping in multi-cross design
    Marie Françoise Jourjon
    INRA, Unité de Biométrie et d Intelligence Artificielle B P 27, 31326 Castanet Tolosan, France
    Bioinformatics 21:128-30. 2005
    ..Marker cofactor selections by forward or backward stepwise methods are implemented as well as computation of threshold test value by permutation...
  31. pmc Asymmetric postmating isolation: Darwin's corollary to Haldane's rule
    Michael Turelli
    Section of Evolution and Ecology, University of California, Davis, California 95616, USA
    Genetics 176:1059-88. 2007
    ..Comparing our predictions to data from diverse taxa indicates that unidirectional DMIs, specifically involving sex chromosomes, cytoplasmic elements, and maternal effects, are likely to play an important role in postmating isolation...
  32. ncbi Strategies for mapping and cloning quantitative trait genes in rodents
    Jonathan Flint
    Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Nat Rev Genet 6:271-86. 2005
    ..We review the potential of these strategies to identify genes that underlie QTLs in rodents...
  33. ncbi Segregation of QTL for production traits in commercial meat-type chickens
    D J De Koning
    Roslin Institute, Roslin, Midlothian EH25 9PS, UK
    Genet Res 83:211-20. 2004
    ..Future fine-mapping efforts could elucidate whether ancestral mutations are still segregating as a result of pleiotropic effects on fitness traits or whether this variation is due to new mutations...
  34. pmc High potential of a transposon mPing as a marker system in japonica x japonica cross in rice
    Yuki Monden
    Plant Breeding Laboratory, Division of Agronomy and Horticulture Science, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    DNA Res 16:131-40. 2009
    ..Moreover, we could easily map two novel loci involved in the culm length on the short arms of chromosomes 3 and 10...
  35. pmc Genetics of hybrid incompatibility between Lycopersicon esculentum and L. hirsutum
    Leonie C Moyle
    Center for Population Biology, University of California, Davis, California 95616, USA
    Genetics 169:355-73. 2005
    ..The observed differences between Lycopersicon and Drosophila might be due to differences in sex determination system, reproductive and mating biology, and/or the prevalence of sexual interactions such as sexual selection...
  36. ncbi Mapping quantitative trait loci for yield, yield components and morphological traits in an advanced backcross population between Oryza rufipogon and the Oryza sativa cultivar Jefferson
    M J Thomson
    Department of Plant Breeding, 240 Emerson Hall, Cornell University, Ithaca, NY 14853 1901, USA
    Theor Appl Genet 107:479-93. 2003
  37. pmc Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast
    Ann Demogines
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 4:e1000123. 2008
    ..It also provides tools for understanding the effect of genetic background on sensitivity to genotoxic agents...
  38. ncbi Genome-wide, large-scale production of mutant mice by ENU mutagenesis
    M H Hrabe de Angelis
    Institute of Experimental Genetics, GSF Research Center for Environment and Health, Neuherberg, Germany
    Nat Genet 25:444-7. 2000
    ..Our mutant lines are freely accessible to non-commercial users (for information, see
  39. ncbi Epigenetic inheritance at the agouti locus in the mouse
    H D Morgan
    Department of Biochemistry, University of Sydney, NSW, 2006, Australia
    Nat Genet 23:314-8. 1999
    ..Because retrotransposons are abundant in mammalian genomes, this type of inheritance may be common...
  40. ncbi Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice
    Naoya Yahagi
    Department of Internal Medicine, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    J Biol Chem 277:19353-7. 2002
    ..In conclusion, SREBP-1 regulation of lipogenesis is highly involved in the development of fatty livers but does not seem to be a determinant of obesity in Lep(ob)/Lep(ob) mice...
  41. ncbi Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
    H Bueler
    Institut für Molekularbiologie I, Universitat Zurich, Switzerland
    Nature 356:577-82. 1992
    ..It is now feasible to determine whether mice devoid of PrPC can propagate prions and are susceptible to scrapie pathogenesis...
  42. pmc Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1
    S Zhang
    Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Proc Natl Acad Sci U S A 95:2429-34. 1998
  43. ncbi Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice
    K Shimomura
    Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois 60208 3520, USA
    Genome Res 11:959-80. 2001
  44. pmc Extensive demethylation of repetitive elements during seed development underlies gene imprinting
    Mary Gehring
    Howard Hughes Medical Institute HHMI, Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Science 324:1447-51. 2009
    ..These data suggest that imprinting in plants evolved from targeted methylation of transposable element insertions near genic regulatory elements followed by positive selection when the resulting expression change was advantageous...
  45. pmc Extragenic bypass suppressors of mutations in the essential gene BLD2 promote assembly of basal bodies with abnormal microtubules in Chlamydomonas reinhardtii
    A M Preble
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA
    Genetics 157:163-81. 2001
    ..It is likely that BLD2 is an essential gene that is needed for basal body assembly and function...
  46. pmc A Drosophila seminal fluid protein, Acp26Aa, stimulates egg laying in females for 1 day after mating
    L A Herndon
    Section of Genetics and Development, Cornell University, Ithaca, NY 14853 2703, USA
    Proc Natl Acad Sci U S A 92:10114-8. 1995
    ..This effect is apparent only on the first day after mating. The null mutation has no other detectable physiological or behavioral effects on the male or the mated female...
  47. pmc The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
    A C Spradling
    Department of Embryology, Howard Hughes Medical Institute Research Laboratories, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Genetics 153:135-77. 1999
    ..We predict that this approach can bring >85% of all Drosophila open reading frames under experimental control...
  48. ncbi ATM is required for telomere maintenance and chromosome stability during Drosophila development
    Elizabeth Silva
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, T6G 2E9, Canada
    Curr Biol 14:1341-7. 2004
  49. pmc The maternally inherited regulation of P elements in Drosophila melanogaster can be elicited by two P copies at cytological site 1A on the X chromosome
    S Ronsseray
    Mécanismes Moléculaires de la Spéciation, Universite Paris, France
    Genetics 129:501-12. 1991
    ..By contrast, the partial regulation of delta 2-3(99B) somatic activity is chromosomally inherited. These results suggest that the regulatory P elements of the Lk-P(1A) line are inserted near a germline-specific enhancer...
  50. pmc Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues
    Lara S Carroll
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0841, USA
    Proc Natl Acad Sci U S A 99:2187-92. 2002
  51. ncbi Morphological intergration between development compartments in the Drosophila wing
    C P Klingenberg
    Department of Zoology, Duke University, Durham, North Carolina 27708 0325, USA
    Evolution 54:1273-85. 2000
    ..In contrast, much less of the shape variation in our sample can be attributed to the localized processes that establish the identity of particular wing veins...
  52. ncbi Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci
    Barry Malmanger
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Mamm Genome 17:1193-204. 2006
    ..We conclude that mapping in HS animals not only provides significantly greater QTL resolution, at least in some cases it provides significantly more information about the QTL haplotype structure...
  53. ncbi Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice
    Katrine Almind
    Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 53:3274-85. 2004
    ..e., the "thrifty gene," is a dominant-acting genetic determinant of diet-induced obesity in mice and can be linked to a locus on chromosome 14, including genes linked to adipose development and insulin sensitivity...
  54. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    ..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
  55. pmc Recombination can initiate and terminate at a large number of sites within the rosy locus of Drosophila melanogaster
    S H Clark
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06268
    Genetics 118:261-6. 1988
    ..Contrary to expectation, significant recombination between these sites is seen...
  56. ncbi Maintenance of CpG methylation is essential for epigenetic inheritance during plant gametogenesis
    Hidetoshi Saze
    Friedrich Miescher Institute for Biomedical Research, P O Box 2543, CH 4002 Basel, Switzerland
    Nat Genet 34:65-9. 2003
  57. pmc Coordinated genetic regulation of growth and lignin revealed by quantitative trait locus analysis of cDNA microarray data in an interspecific backcross of eucalyptus
    Matias Kirst
    Forest Biotechnology Group, North Carolina State University, Raleigh, NC 27695, USA
    Plant Physiol 135:2368-78. 2004
    ..Sequence data for this article have been deposited with the EMBL/GenBank data libraries under accession numbers CB 967505 to CB 968059; CD 667988 to CD 670002; CD 670004; CD 670097; CD 670101 to CD 670112; and CD 670114 to CD 670137.)..
  58. ncbi Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice
    K E Browman
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, 97201, USA
    Alcohol Clin Exp Res 24:17-23. 2000
    ..Many QTL analyses have been performed in BXD recombinant inbred (RI) strains of mice derived from a cross of C57BL/6J (B6) and DBA/2J (D2) progenitor strains...
  59. pmc Dominance, overdominance and epistasis condition the heterosis in two heterotic rice hybrids
    Lanzhi Li
    Key Lab of the Ministry of Education for Plant Developmental Biology, College of Life Science, Wuhan University, Wuhan, China
    Genetics 180:1725-42. 2008
    ..0 to 14.9%. These results suggest that the heterosis in these two hybrids is attributable to the orchestrated outcome of partial-to-complete dominance, overdominance, and epistasis...
  60. pmc Classical genetic and quantitative trait loci analyses of heterosis in a maize hybrid between two elite inbred lines
    Elisabetta Frascaroli
    Department of Agroenvironmental Sciences and Technologies, University of Bologna, 40127 Bologna, Italy
    Genetics 176:625-44. 2007
    ..Some chromosome regions presented overlaps of overdominant QTL for SW, PH, NK, and GY, suggesting pleiotropic effects on overall plant vigor...
  61. ncbi Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
    R Bremner
    Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland
    Cell 61:407-17. 1990
    ..We conclude that gross chromosomal alterations that elevate the copy number of mutant H-ras and/or lead to loss of normal H-ras are a consistent feature of mouse skin tumor development...
  62. pmc QTL mapping in new Arabidopsis thaliana advanced intercross-recombinant inbred lines
    Sureshkumar Balasubramanian
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tubingen, Germany
    PLoS ONE 4:e4318. 2009
    ..One strategy to increase the power of precisely localizing small effect QTL, is the use of an intercross approach before inbreeding to produce Advanced Intercross RILs (AI-RILs)...
  63. ncbi Reinforcement drives rapid allopatric speciation
    Conrad J Hoskin
    School of Integrative Biology, University of Queensland, St Lucia, Queensland 4072, Australia
    Nature 437:1353-6. 2005
    ..Thus we show the potential for reinforcement to drive rapid allopatric speciation...
  64. pmc Evolutionary history of Silene latifolia sex chromosomes revealed by genetic mapping of four genes
    Dmitry A Filatov
    School of Biosciences, University of Birmingham, Edgbaston, UK
    Genetics 170:975-9. 2005
  65. pmc Local spreading of MSL complexes from roX genes on the Drosophila X chromosome
    Hyangyee Oh
    Interdepartmental Program in Cell and Molecular Biology, Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 17:1334-9. 2003
    ..Thus, the protein components can carry out all essential functions of dosage compensation, but roX RNAs facilitate the correct targeting of MSL complexes, in part by nucleation of spreading from their sites of synthesis...
  66. ncbi Insulin regulation of heart function in aging fruit flies
    Robert J Wessells
    The Burnham Institute, Center for Neuroscience and Aging, 10901 Torrey Pines Road, La Jolla, California 92037, USA
    Nat Genet 36:1275-81. 2004
    ..The aging fly heart is a model for studying the genetics of age-sensitive organ-specific pathology...
  67. ncbi Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation
    Mariana de Napoles
    Developmental Epigenetics Group, MRC Clinical Sciences Centre, ICFM, Hammersmith Hospital, DuCane Road, London W12 ONN, United Kingdom
    Dev Cell 7:663-76. 2004
    ..These observations link H2A ubiquitylation, X inactivation, and PRC1 PcG function, suggesting an unanticipated and novel mechanism for chromatin-mediated heritable gene silencing...
  68. ncbi Cytoplasmic male sterility: a window to the world of plant mitochondrial-nuclear interactions
    Christine D Chase
    Horticultural Sciences Department, University of Florida Institute of Food and Agricultural Sciences, Gainesville, FL 32611 0690, USA
    Trends Genet 23:81-90. 2007
    ..The molecular cloning of nuclear genes that restore fertility (i.e. restorer-of-fertility genes) has identified genes encoding pentatricopeptide-repeat proteins as key regulators of plant mitochondrial gene expression...
  69. pmc On the detection of imprinted quantitative trait loci in experimental crosses of outbred species
    Dirk Jan de Koning
    Animal Breeding and Genetics Group, Wageningen Institute of Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands
    Genetics 161:931-8. 2002
    ..When QTL were segregating in the founder lines, spurious detection of imprinting became more prominent under both tests, especially for designs with a small number of F1 sires...
  70. ncbi Genetic linkage of ecological specialization and reproductive isolation in pea aphids
    D J Hawthorne
    Department of Entomology, University of Maryland, College Park 20742, USA
    Nature 412:904-7. 2001
    ..This type of genetic architecture may be common in taxa that have speciated under divergent natural selection...
  71. ncbi Fine mapping of a yield-enhancing QTL cluster associated with transgressive variation in an Oryza sativa x O. rufipogon cross
    Xiaobo Xie
    College of Agriculture and Life Sciences, Chungnam National University, Daejeon, 305 764, South Korea
    Theor Appl Genet 116:613-22. 2008
    ..4 kb interval suggests the possibility that a single, pleiotropic gene acting as a major regulator of plant development may control this suite of agronomically important plant phenotypes...
  72. ncbi Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene
    Thomas N Ferraro
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 15:239-51. 2004
    ..The critical interval contains several candidate genes, one of which, Kcnj10, exhibits a potentially important polymorphism with regard to fundamental aspects of seizure susceptibility...
  73. ncbi Distinct genetic loci control development of benign and malignant skin tumours in mice
    H Nagase
    CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, UK
    Nat Genet 10:424-9. 1995
    ..On the other hand, probably a single locus on chromosome 5 affects both early and late stages of malignancy. The results indicate that benign and malignant tumours are largely under independent genetic control...
  74. ncbi Development, utilization of introgression lines using a synthetic wheat as donor
    Shubing Liu
    Key Lab of Crop Germplasm and Biotechnology, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, 100081, Beijing, China
    Theor Appl Genet 112:1360-73. 2006
    ..In total, 38, 33, and 28 putative QTLs were detected for seven of the nine traits in 2003, 2004, and 2005, respectively. Some of these agronomic important QTLs were detected in more than one season...
  75. pmc Mapping quantitative trait loci (QTLs) for fatty acid composition in an interspecific cross of oil palm
    Rajinder Singh
    Advanced Biotechnology and Breeding Centre, Biology Division, Malaysian Palm Oil Board MPOB, NO, 6, Persiaran Institusi, Selangor DE, Malaysia
    BMC Plant Biol 9:114. 2009
    ..This will speed up the production of new and improved oil palm planting materials...
  76. pmc A fine-scale genetic analysis of hybrid incompatibilities in Drosophila
    Daven C Presgraves
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Genetics 163:955-72. 2003
    ..Finally, I estimate that a total of approximately 191 hybrid-lethal incompatibilities separate D. melanogaster and D. simulans, indicating extensive functional divergence between these species' genomes...
  77. ncbi Cancer susceptibility in the mouse: genetics, biology and implications for human cancer
    Peter Demant
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Rev Genet 4:721-34. 2003
    ..In future, this unique approach is likely to provide important insights into the pathways of tumour development and might ultimately lead to more effective individually targeted cancer-prevention strategies...
  78. ncbi A composite linkage map from two crosses for the species complex Picea mariana x Picea rubens and analysis of synteny with other Pinaceae
    Betty Pelgas
    Chaire de recherche du Canada en génomique forestière et environnementale, Centre de recherche en biologie forestière, Pavillon Charles Eugène Marchand, Universite Laval, Sainte Foy, QC, G1K 7P4, Canada
    Theor Appl Genet 111:1466-88. 2005
    ..Implications for the evolution of the Pinaceae genome are discussed...
  79. pmc Diversifying selection in plant breeding
    Susan McCouch
    Department of Plant Breeding and Genetics at Cornell University, Ithaca, New York, USA
    PLoS Biol 2:e347. 2004
  80. ncbi Genetic mapping of quantitative trait loci for growth and fatness in pigs
    L Andersson
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala
    Science 263:1771-4. 1994
    ..The genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity...
  81. ncbi Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
    D J Rawlings
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024
    Science 261:358-61. 1993
    ..A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions...
  82. ncbi Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries
    M E Grigg
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5124, USA
    Science 294:161-5. 2001
    ..Thus, sexual recombination, by combining polymorphisms in two distinct and competing clonal lines, can be a powerful force driving the natural evolution of virulence in this highly successful pathogen...
  83. pmc Iron accumulation with age, oxidative stress and functional decline
    Jinze Xu
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 3:e2865. 2008
    ..These findings strongly suggest that the age-related iron accumulation in muscle contributes to increased oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects...
  84. pmc Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr mice
    S Vidal
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 101:696-702. 1998
    ..The identification of loci with highly significant linkage to disease manifestations in Faslpr strains will make it possible to map and clone new genetic defects contributing to autoimmunity...
  85. pmc Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice
    G A Brockmann
    Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Genome Res 10:1941-57. 2000
    ..The quantitative trait loci described in this paper have been submitted to the Mouse Genome Database.]..
  86. pmc The genetic architecture of fitness in a seed beetle: assessing the potential for indirect genetic benefits of female choice
    T Bilde
    Animal Ecology Department of Ecology and Evolution, Evolutionary Biology Centre, University of Uppsala, Uppsala SE 753 32, Sweden
    BMC Evol Biol 8:295. 2008
    ..From reciprocal crosses of inbred lines, we assayed egg production, egg-to-adult survival, and lifetime offspring production of the outbred F1 daughters (F1 productivity)...
  87. ncbi Genetics and the fitness of hybrids
    J M Burke
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Annu Rev Genet 35:31-52. 2001
    ..In contrast, increased hybrid fitness can be most readily explained through the segregation of additive genetic factors, with epistasis playing a more limited role...
  88. pmc A genome-wide survey of hybrid incompatibility factors by the introgression of marked segments of Drosophila mauritiana chromosomes into Drosophila simulans
    J R True
    Department of Zoology, Duke University, Durham, North Carolina 27708, USA
    Genetics 142:819-37. 1996
  89. pmc Identification of nitric oxide synthase as a protective locus against tuberculosis
    J D MacMicking
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:5243-8. 1997
    ..Progression of chronic tuberculosis in wild-type mice was accelerated by specifically inhibiting NOS2 via administration of N6-(1-iminoethyl)-L-lysine. Together these findings identify NOS2 as a critical host gene for tuberculostasis...
  90. ncbi Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    T Takahashi
    Osaka Bioscience Institute, Japan
    Cell 76:969-76. 1994
    ..These results indicate that lpr and gld are mutations in Fas and Fasl, respectively, and suggest important roles of the Fas system in development of T cells as well as cytotoxic T lymphocyte-mediated cytotoxicity...
  91. ncbi Tumor spectrum analysis in p53-mutant mice
    T Jacks
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    Curr Biol 4:1-7. 1994
    ..The construction of mouse strains carrying germline mutations of p53 facilitates analysis of the function of p53 in normal cells and tumorigenesis...
  92. pmc Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
    C G Specht
    Laboratory for Molecular Pharmacology, UCL, Gower Street, London WC1E 6BT, UK
    BMC Neurosci 2:11. 2001
    ..Here we analyze potential compensatory mechanisms in alpha-synuclein null mutant mice. Furthermore, the findings reveal problems that may be associated with inbred mouse strains...
  93. pmc An improved method for quantitative trait loci detection and identification of within-line segregation in F2 intercross designs
    Lars Rönnegård
    Linnaeus Centre for Bioinformatics, Uppsala University, 75124 Uppsala, Sweden
    Genetics 178:2315-26. 2008
    ..Extensions of FIA and its applications on other intercross populations including backcrosses, advanced intercross lines, and heterogeneous stocks are also discussed...
  94. ncbi Effect of population size on the estimation of QTL: a test using resistance to barley stripe rust
    M I Vales
    Department of Crop and Soil Science, Oregon State University, Corvallis, OR 97331 3002, USA
    Theor Appl Genet 111:1260-70. 2005
    ..The method of choice will depend on the relative costs of genotyping versus phenotyping...
  95. ncbi Quantitative trait locus mapping for meat quality traits in an Iberian x Landrace F2 pig population
    C Ovilo
    Departamento de Mejora Genética Animal, INIA, Carretera La Coruña km 7, 28040 Madrid, Spain
    J Anim Sci 80:2801-8. 2002
    ..In this work we identify genomic regions related with meat quality traits. Improvement by traditional selection methods is complicated, and finer mapping would be required for their application in introgression programs...
  96. pmc Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster
    Stuart J Macdonald
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
    Genetics 176:1261-81. 2007
    ..Models that seek to explain the maintenance of genetic variation make different predictions about the population frequency of QTL alleles. Thus, mapping QTL in eight-way recombinant populations can distinguish between these models...
  97. pmc Weighted gene coexpression network analysis strategies applied to mouse weight
    Tova F Fuller
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Mamm Genome 18:463-72. 2007
    ..These examples provide evidence that integration of network properties may well help chart the path across the gene-trait chasm...
  98. ncbi Leaf tip necrosis, molecular markers and beta1-proteasome subunits associated with the slow rusting resistance genes Lr46/Yr29
    G M Rosewarne
    International Maize and Wheat Improvement Center CIMMYT, Apartado Postal 6 641, 06600, Km 45 Carretera Mexico Veracruz, 56130 El Batan, Texcoco, Mexico
    Theor Appl Genet 112:500-8. 2006
    ..Coincidentally, members of a small gene family encoding beta-1 proteasome subunits located on group 1L and 7S chromosomes implicated in plant defense were linked to the Lr34/Yr18 and Lr46/Yr29 loci...
  99. ncbi Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice
    H Baribault
    La Jolla Cancer Research Foundation, California 92037
    Genes Dev 8:2964-73. 1994
    ..More importantly, the increase in mK8-/- gut epithelial cell number, rather than cell disruption, contrasts with the known function of epidermal keratins in providing mechanical strength...
  100. ncbi Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout
    Jean M Jasinski
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
    Diabetes 55:1978-84. 2006
    ..scid mouse. The current study demonstrates that the BDC12-4.1 TCR is sufficient to cause diabetes at NOD backcross 1, bypassing polygenic inhibition of insulitis and diabetogenesis...
  101. pmc Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis
    I Kramnik
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 667 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:8560-5. 2000
    ..tuberculosis, indicating that other genes located outside of the sst1 locus are likely also to be important for controlling tuberculosis infection...

Research Grants63

  1. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir S El-Dahr; Fiscal Year: 2013
    ..b>Genetic crosses to reporter mice will reveal the spatiotemporal dynamics of Pax2 gene transcription in Bdkrb2-mutants...
  2. Genetics of Alopecia Areata in the C3H/HeJ Mouse
    JOHN PAUL SUNDBERG; Fiscal Year: 2013
    ..capabilities, adding Expression-based Quantitative Trait Locus (EQTL) analytical methods to analyze new genetic crosses. By evaluating mice that develop AA in the separate aging of Collaborative Cross mice (nearly 200 carefully ..
  3. Innate immunity in Rett pathology and repair
    Jonathan Kipnis; Fiscal Year: 2013
    ..IGF-1 and microglia-derived IGF-1 in arrest of Rett disease, using bone marrow transplantation and genetic crosses;and (3) testing the hypothesis that the deficiency in phagocytic clearance by microglia may underlie, in part,..
  4. The Role of Ets1 in Melanocyte Development
    Lidia Kos; Fiscal Year: 2012
    ..Additionally, we will perform genetic crosses, promoter analysis and binding assays to evaluate the interaction of Ets1 with Sox10, Pax3, and Mitf...
  5. Determinants of growth and fitness in drug resistant malaria parasites
    Michael T Ferdig; Fiscal Year: 2012
    ..This knowledge will lead to new avenues of attack against this disease. ..
  6. Mechanisms of Autoimmune Activation and Regulation by Innate Immune Receptors
    Mark J Shlomchik; Fiscal Year: 2013
    ..Again, we will use genetic approaches to create novel overexpressing mice. In Aim 3 we will use F2 genetic crosses to test the roles in disease of the remaining known innate immune nucleic acid sensing pathways and the ..
  7. Genetic and Developmental Mechanisms of Evolutionary Innovations
    Artyom Kopp; Fiscal Year: 2012
    ..will be developed in a Drosophila model, which allows genomic and population-genetic data to be combined with genetic crosses and experimental analyses of gene regulation and function...
    GAIL ROBERTA MARTIN; Fiscal Year: 2010
    ..gene expression, performing experiments in tooth organ cultures, and by analyzing the progeny of complex genetic crosses, we will determine how loss of Sprouty gene function enables diastema tooth buds to persist and develop into ..
  9. Genetic Analysis of Host Specificity in Schistosoma mansoni
    Tim J Anderson; Fiscal Year: 2013
    ..For both traits, we will conduct genetic crosses between Brazilian and Egyptian S...
  10. Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
    Jessica A Lehoczky; Fiscal Year: 2010
    ..Regulatory mutations and dominant mutations identified from this proposal will provide sequences that could be screened in human patients, for whom no mutations have yet been identified. ..
  11. Growth Factor Signaling in Mouse Palatogensis
    YiPing Chen; Fiscal Year: 2013
    ..A combination of genetic crosses, histological, cellular and molecular assays, as well as in vitro organ culture and cell migration assays ..
  12. Diapause in Culex Mosquitoes
    David W Severson; Fiscal Year: 2013
    ..Information from genetic crosses will be leveraged against the Cx...
  13. A new system for mammalian cell genetics using a haploid genomic context
    Thijn Brummelkamp; Fiscal Year: 2010
    ..screens in mammalian cells are limited by the diploid state of their genome and the inability to perform genetic crosses. Genetic screens reliant on RNA interference (RNAi) are commonly thought to surpass these limitations...
  14. Growth hormone signaling and lipid metabolism in fatty liver disease
    ETHAN WEISS; Fiscal Year: 2013
    ..Overall, this work will lead to a greater understanding of how GH signaling serves to modulate lipid metabolism and how alterations in GH signaling can lead to the abnormal accumulation of lipid in the liver and other tissues. ..
  15. Aging and the Tissue Response to Misfolded Proteins
    Joel N Buxbaum; Fiscal Year: 2012
    ..We will use genomic and proteomic analyses and genetic crosses to investigate the molecular events in the liver, the state of circulating transthyretin, transcription ..
  16. Mapping and modeling host-pathogen interactions in TB latency and reactivation
    Eduardo Sontag; Fiscal Year: 2013
    ..Our goal is to subvert these networks to the host advantage with new vaccines and drugs targeting critical network nodes. ..
  17. Role of 14-3-3o in development and repair of corneal epithelium
    Qiutang Li; Fiscal Year: 2013
    ..These studies involve both cell culture and genetic cross using 14-3-3[unreadable] mutant mice. ..
  18. Analysis of Toxoplasma sexual development in polarized cat intestinal cells
    Laura J Knoll; Fiscal Year: 2013
    ..Creation of ex vivo sexual development conditions will allow classical genetic crosses to become routine in laboratories, which will open multiple new experimental design strategies...
  19. Functional analysis of ADAMTS13
    David G Motto; Fiscal Year: 2010
    ..TTP-like finding were induced with a combination of environmental factors (shigatoxin administration) and genetic crosses (to the CASA/Rk mouse strain)...
  20. Sex-Specific Regulation of Meiotic Recombination Hotspots
    Petko M Petkov; Fiscal Year: 2013
    ..We will use genetic crosses that will allow us to assess dominance issues and dosage effects separately, for which we will create new ..
  21. Investigating the molecular basis of primaquine resistance
    Elizabeth A Winzeler; Fiscal Year: 2011
    ..Loci that are implicated in resistance will be confirmed through allelic exchange, complementation or genetic crosses. The proposed studies will accelerate malaria parasite resistance studies in the following ways...
  22. Function and mechanism of REDD1/mTOR signaling in metabolism and tumorigenesis
    Leif W Ellisen; Fiscal Year: 2013 which REDD1 silencing activates autophagy and the glycolytic switch to drive tumorigenesis, through genetic crosses and through analysis of our established repository of thousands of genotyped human tumors...
  23. Dissecting Tumor Heterogeneity by Analyzing Signaling Pathway Requirements.
    ERAN ROBERT ANDRECHEK; Fiscal Year: 2013
    ..aim we will test the hypothesis that the E2Fs regulate HER2+ breast cancer in mouse model systems through genetic crosses where we ablate individual E2Fs in the MMTV-Neu transgenic model systems...
  24. The Mechanism of Genetic Exchange in Trichomonas vaginalis
    Andrew W Gorman; Fiscal Year: 2013
    ..Trichomonas vaginalis biology, control, and treatment but also open the door to the possibility of utilizing genetic crosses, a powerful tool with great potential which can be employed to facilitate molecular studies and begin to ..
  25. Identification of Flat Colorectal Cancer Modifiers
    DAVID JAMES BAUTZ; Fiscal Year: 2013
    ..Understanding the factors that control tumor morphology will aid in identifying candidate biomarkers for their identification and potential new targets for therapeutic intervention. ..
  26. Statistical Modeling of Complex Traits in Genetic Reference Super-Populations
    William Valdar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Genetic crosses in model organisms play an essential role in understanding the heritable architecture of medically relevant phenotypes...
  27. Notch signaling in cardiovascular morphogenesis
    Jonathan A Epstein; Fiscal Year: 2013
    ..The revised application involves fewer genetic crosses is more mechanistic than the original submission...
    L David Sibley; Fiscal Year: 2013
    ..gondii, and characterize their cellular and biochemical mechanisms of action. Additional genetic crosses between different parasite genotypes will be undertaken to map genes that regulate differences in ..
  29. Regulation of GABAergic Neuron Differentiation
    Brian Condie; Fiscal Year: 2005
    ..In the third Aim, genetic crosses between a Gad1-lacZ "knockin" mouse strain developed by the PI and transcription factor knockout mice are ..
  30. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..dominant genetic marker and agrobacterium as the gene delivery vehicle, developed congenic strains to conduct genetic crosses and establish linkage, and implemented approaches to identify the mutated genes...
    Thaddeus Kurczynski; Fiscal Year: 1980
    ..Various genetic crosses will be made utilizing fibroblasts from humans and dogs with GLD...
    Karen Stevens; Fiscal Year: 2001
    ..Such information could be important in understanding of the etiology of the disorder and in determining future therapeutic interventions. ..
    David Kabat; Fiscal Year: 1999
    ..By genetic crosses, identify mouse genes that restrict Pvu-delta but not wild-type SFFV...
    Karen Reue; Fiscal Year: 2002
    ..In addition, we compare Bailey and J substrains for susceptibility to aortic lesion development, as a model in which similar HDL levels occur in conjunction with vastly different LDL/VLDL levels. ..
  35. Genes on Chromosome 17 Regulating % Body Fat in the Mouse
    DAVID BRIAN WEST; Fiscal Year: 2013
    ..Linkage in this region on proximal Chr17 has been identified in numerous other mouse genetic crosses using different substrains of C57 mice, and the C57 allele is always the allele conferring increased risk for ..
  36. Disproportionate Dwarfism in the Mouse Mutant Rhizomelia
    DAVID BERGSTROM; Fiscal Year: 2005
    ..After creating deletion-bearing mice, genetic crosses will be used to place rzm in trans to the encompassing deletion (rzm/A)...
    Andrew Caton; Fiscal Year: 2007
    ..We showed that antibody is not required for arthritis development, and that genetic crosses that increased the frequency of CD4+ T cells expressing the transgenic TCR caused arthritis to develop more ..
    Harry Drabkin; Fiscal Year: 2006
    ..b>Genetic crosses in flies demonstrate that the effects of Trc8 overexpression are corrected by cyclin E and exacerbated by the ..
  39. Genetic Mechanisms of Vertebrate Caudal Limb Field Specification
    JEFFREY INNIS; Fiscal Year: 2007
    ..assess the contribution of strain variation to penetrance and phenotypic variation we will perform additional genetic crosses to priority Group A Mouse Phenome Project strains...
  40. Building better animal models of prostate cancer
    Milton Datta; Fiscal Year: 2004
    ..Here we propose the studies necessary to validate and extend the identified chromosomal regions through genetic crosses. In addition, in order to shorten the interval to phenotypic evaluation we propose to develop a better ..
    JEANNE WEHNER; Fiscal Year: 2001
    ..with QTLs identified in other laboratories regulating emotionality or contextual fear conditioning in other genetic crosses. Thus, both QTLs that generalize across strains of mice and QTLs specific to the differences between B6 and ..
  42. Identification and Functional Analysis of the Mouse Deaf
    David Kohrman; Fiscal Year: 2005
  43. Reverse genetics of mosquito systemic immunity
    Alexander Raikhel; Fiscal Year: 2009
    ..The RMID transgenic mosquitoes provide an invaluable tool to assess the properties of AMPs in various genetic crosses involving transgenic knock-outs of immune pathways...
    LESLIE KOZAK; Fiscal Year: 2004
    ..For QTLs whose effect remains robust when examined in isolation as a congenic line, further genetic crosses will be carried out in Aim 2 to narrow the region; in addition, corresponding strains from a genome-wide ..
    Donald Metcalf; Fiscal Year: 2004
    ..the specificity of different SOCS proteins in inhibiting the actions of different cytokines by performing genetic crosses of mice with different SOCS or cytokine deletions; and (3) to identify the physiological molecular targets ..
  46. Ion Transport Dysregulation in Cilium-deficient ARPKD
    MARK BEVENSEE; Fiscal Year: 2009
    ..Interrelated specific aims derive from this hypothesis and are designed to understand the cellular and molecular mechanisms that underlie this ARPKD disease phenotype. ..
    Aldons Lusis; Fiscal Year: 1999
    ..QT,I- mapping is being applied to the analysis of lipoprotein metabolism and atherogenesis in several large genetic crosses between strains of mice differing in lipoprotein metabolism...
  48. A Novel Modifier Locus Suppressing ApcMin Intestinal Polyposis
    STEPHANIE NNADI; Fiscal Year: 2009
    ..C3H and C3H.B6 reciprocal congenic crosses, and 3) a BXH Rl line backcross. In Specific Aim 1, classical genetic crosses involving congenic and consomic mice will be used to narrow the boundaries of the Mom4 locus...
  49. Cell-specific Gene Targeting in Urologic Tissues
    JAMES CATTERALL; Fiscal Year: 2005 the testicular feminized mouse, Tfm/Y) has effects that mask the role of androgens in renal growth, development and function. The proposed research addresses several of the research goals of the Program Announcement. ..
  50. Genetic control of cross-resistances in P. falciparum
    Michael Ferdig; Fiscal Year: 2007
    ..Locus-specific transcription will be evaluated using quantitative PCR and long oligonucleotide micro-arrays to identify heritable expression polymorphisms that coincide with drug responses. ..
    RICHARD MCPARTLAND; Fiscal Year: 1980
    ..These biochemical differences can then be analyzed in genetic crosses to determine if the biochemical trait segregates with blood pressure...
    THOMAS GOLDSWORTHY; Fiscal Year: 1999
    ..b>Genetic crosses of rodents with different phenotypes and genotypes have been critical to verifying the role of activation of ..
  53. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  54. Genetics of Noise Resistance
    BRUCE TEMPEL; Fiscal Year: 2007
    ..SA 4. Strong candidate genes will be tested in genetic crosses to determine whether they interact functionally with the NIHL-resistant QTL...
    ANDREW THLIVERIS; Fiscal Year: 2004
    ..b>Genetic crosses will be done in a way to facilitate mapping of newly acquired mutations that result in retinal tumors...
    Margaret Ross; Fiscal Year: 2003
    ..In Aim 3, genetic crosses will test the hypothesis that Dbcn is part of an intracellular signaling cascade and is activated by the cAbl ..
    Gregory Dressler; Fiscal Year: 1999
    ..Ultimately, understanding the regulation and function of transcription factors in renal diseases may lead to novel therapeutic interventions based on modulating gene expression. ..
    Peter Igarashi; Fiscal Year: 2002
    ..b>Genetic crosses will be performed to determine whether mutations of Cux-1 reduce cyst formation in cpk mutant mice...
    Leonard Shultz; Fiscal Year: 2002
    ..b>Genetic crosses between these transgenic mice and me/me mice will result in the selective rescue of SHP-1 expression in ..
  60. New Rat Model of Autoimmune Diabetes And Arthritis
    Dennis Guberski; Fiscal Year: 2002
    ..In Phase 1 we will establish a foundation colony of LEW.1WR1 rats and begin genetic crosses to introgress traits from BBDR/Wor and LEW.1WR strains...
    JEFFREY INNIS; Fiscal Year: 2000
    ..We have built a high-resolution genetic map of the Hd locus using genetic crosses involving over 1,500 mice (Innis et al., 1995a, 1995b)...
    David Beach; Fiscal Year: 2000
    ..can be used to distinguish whether animals are heterozygous or homozygous for the insertion event, allowing genetic crosses to be followed without the need for molecular analysis...
  63. Transcriptional network analysis in malaria parasites.
    JOSEPH GONZALES; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..