Genomes and Genes
Summary: The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Publications307 found, 100 shown here
- Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary diseasePeter M A Calverley
University Hospital Aintree, Liverpool, United Kingdom
N Engl J Med 356:775-89. 2007..Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown...
- The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterolHarold S Nelson
National Jewish Medical and Research Center, Denver, CO, USA
Chest 129:15-26. 2006..To compare the safety of salmeterol xinafoate or placebo added to usual asthma care...
- Inhaled corticosteroid use in chronic obstructive pulmonary disease and the risk of hospitalization for pneumoniaPierre Ernst
Pharmacoepidemiology Research Unit, Department of Medicine, McGill University Health Centre, and Division of Clinical Epidemiology, Ross 4 29, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, PQ, Quebec, H3A 1A1 Canada
Am J Respir Crit Care Med 176:162-6. 2007..Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD)...
- Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPDJ A Van Noord
Dept of Respiratory Diseases, Atrium Medisch Centrum, Henri Dunantstraat 5, 6419 PC Heerlen, The Netherlands
Eur Respir J 26:214-22. 2005..i.d. A combination of both drugs q.d. was most effective and provided an additive effect throughout the 24-h dosing interval...
- Hospitalizations and mortality in the Lung Health StudyNicholas R Anthonisen
University of Manitoba, Winnipeg, Manitoba, Canada
Am J Respir Crit Care Med 166:333-9. 2002..When all participants were considered and smoking status considered as a time-dependent covariate, smoking cessation was associated with significant reductions in fatal or nonfatal cardiovascular disease and coronary artery disease...
- Large porous particles for pulmonary drug deliveryD A Edwards
Department of Chemical Engineering, Pennsylvania State University, 204 Fenske Laboratory, University Park, PA 16802, USA
Science 276:1868-71. 1997..High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles...
- Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary diseaseG C Donaldson
Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
Thorax 57:847-52. 2002..The aim of this study was to investigate whether these are related...
- Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary diseaseD E O'Donnell
Respiratory Investigation Unit, Dept of Medicine, Queen s University, Kingston, Canada
Eur Respir J 24:86-94. 2004..Bronchodilator-induced lung deflation reduced mechanical restriction, increased ventilatory capacity and decreased respiratory discomfort, thereby increasing exercise endurance...
- The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy studyKeith L Hattotuwa
Lung Pathology Unit, Imperial College School of Medicine at the Royal Brompton Hospital, London, United Kingdom
Am J Respir Crit Care Med 165:1592-6. 2002..The data indicate that inhaled fluticasone does affect selected aspects of airway inflammation in COPD, and this may explain, in part, the decrease in exacerbations seen in long-term studies with fluticasone propionate...
- Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung diseaseNeil C Barnes
Department of Respiratory Medicine, London Chest Hospital, London, UK
Am J Respir Crit Care Med 173:736-43. 2006..No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease...
- Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammationB N Lambrecht
Department of Pulmonary Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
J Clin Invest 106:551-9. 2000..These data demonstrate that DCs in the airways induce sensitization to inhaled antigen and that molecules expressed on the surface of these cells are critical for the development of Th2-dependent airway eosinophilia...
- Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroidsRobert F Lemanske
University of Wisconsin School of Medicine and Public Health, Madison, USA
N Engl J Med 362:975-85. 2010..For children who have uncontrolled asthma despite the use of low-dose inhaled corticosteroids (ICS), evidence to guide step-up therapy is lacking...
- Inhaled corticosteroids and risk of pneumonia in newly diagnosed COPDMin J Joo
Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
Respir Med 104:246-52. 2010..Little is known of this risk in newly diagnosed COPD patients. The objective of this study was to determine if the use of ICS among newly diagnosed COPD patients is associated with an increased risk of pneumonia hospitalizations...
- Regular use of inhaled corticosteroids and the long term prevention of hospitalisation for asthmaS Suissa
Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University Health Centre, McGill University, Montreal, Canada
Thorax 57:880-4. 2002..Inhaled corticosteroids are effective at preventing asthma morbidity and mortality. Most studies, however, have focused on short term effects, raising uncertainty about their effectiveness in the long term...
- The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPDMario Cazzola
Unit of Pneumology and Allergology, Department of Respiratory Medicine, A Cardarelli Hospital, Via del Parco Margherita 24, Naples 80121, Italy
Pulm Pharmacol Ther 17:35-9. 2004..Since tiotropium ensures prolonged bronchodilation, whereas formoterol adds fast onset and a greater peak effect, the two drugs appear complementary...
- Regional lung deposition and bronchodilator response as a function of beta2-agonist particle sizeOmar S Usmani
Department of Thoracic Medicine, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
Am J Respir Crit Care Med 172:1497-504. 2005..Aerosol particle size influences the extent, distribution, and site of inhaled drug deposition within the airways...
- Onset of action of single doses of formoterol administered via Turbuhaler in patients with stable COPDM Cazzola
Division of Pneumology and Allergology and Unit of Respiratory Clinical Pharmacology, A Cardarelli Hospital, Naples, Italy
Pulm Pharmacol Ther 14:41-5. 2001..Again, there was no significant difference (P= 0.817) between the four active treatments. Formoterol Turbuhaler 12 microg and 24 microg caused bronchodilation as rapidly as salbutamol 400 microg and 800 microg given via pMDI...
- Inflammatory changes, recovery and recurrence at COPD exacerbationW R Perera
Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, Rowland Hill Street, Hampstead, London, NW3 2PF, UK
Eur Respir J 29:527-34. 2007..A high serum C-reactive protein concentration 14 days after an index exacerbation may be used as a predictor of recurrent exacerbations within 50 days...
- Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysisS Holt
Wellington Asthma Research Group, Wellington School of Medicine, PO Box 7343, Wellington, New Zealand
BMJ 323:253-6. 2001..However, these findings were limited by the lack of data on individual patients and by the paucity of dose-response studies that included doses of >500 microg/day...
- Budesonide and the risk of pneumonia: a meta-analysis of individual patient dataDon D Sin
Providence Heart and Lung Institute, St Paul s Hospital iCAPTURE Centre, and Department of Medicine Division of Respirology, University of British Columbia, Vancouver, BC, Canada
Lancet 374:712-9. 2009..We aimed to establish the effects of inhaled budesonide on the risk of pneumonia in such patients...
- Comparing clinical features of the nebulizer, metered-dose inhaler, and dry powder inhalerDavid E Geller
The Nemours Children s Clinic, Orlando, Florida 32806, USA
Respir Care 50:1313-21; discussion 1321-2. 2005..Clinicians should also have a rudimentary understanding of aerosol principles in order to be able to teach appropriate use of aerosol devices to their patients...
- A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosisM E Hodson
Royal Brompton and Harefield NHS Trust, London, UK
Eur Respir J 20:658-64. 2002..Both treatments reduced the bacterial load...
- Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trialE F M Wouters
Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
Thorax 60:480-7. 2005..Combined treatment with ICS and long acting beta2 agonists (LABA) may provide benefit to the stability of COPD, but it is unknown if withdrawal of ICS will result in disease deterioration...
- Prescription bias and factors associated with improper use of inhalersPiersante Sestini
Department of Clinical Medicine and Immunological Sciences, Section of Respiratory Diseases, University of Siena, Siena, Italy
J Aerosol Med 19:127-36. 2006..The prescription of newer DPIs may be subjected to gender, socio-economic, and instruction bias. The simple change of device from the pMDI to the newer DPIs is not associated with improved inhalation technique...
- The efficacy of tiotropium administered via Respimat Soft Mist Inhaler or HandiHaler in COPD patientsJ A Van Noord
Department of Respiratory Diseases, Atrium Medisch Centrum, Heerlen, The Netherlands
Respir Med 103:22-9. 2009..The Respimat Soft Mist Inhaler (SMI), a novel, propellant-free inhaler, has been developed and proposed as an alternative delivery device for use with tiotropium...
- Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctionsHiromitsu Yamamoto
Gifu Pharmaceutical University, 5 6 1, Mitahora higashi Gifu 502 8585, Japan
J Control Release 102:373-81. 2005..4000)>FD-21 (Mw. 21,000)>FD70 (Mw. 70,000), which corresponded to the molecular weights ([Mw.] given in parentheses). The absorption-enhancing effect may have been caused by opening the intercellular tight junctions...
- Formulation and cytotoxicity of doxorubicin nanoparticles carried by dry powder aerosol particlesShirzad Azarmi
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alta, Canada T6G 2N8
Int J Pharm 319:155-61. 2006..The cell uptake of free DOX and DOX delivered by nanoparticles was confirmed using confocal laser scanning microscopy. This study supports the approach of lung cancer treatment using nanoparticles in dry powder aerosol form...
- The efficacy and safety of combination salmeterol (50 microg)/fluticasone propionate (500 microg) inhalation twice daily via accuhaler in Chinese patients with COPDJin ping Zheng
Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, People s Republic of China
Chest 132:1756-63. 2007....
- Characteristics of U.S. waterpipe users: a preliminary reportKenneth D Ward
Department of Health and Sport Sciences, University of Memphis, Memphis, TN 38152, USA
Nicotine Tob Res 9:1339-46. 2007..Educational efforts are needed to increase awareness of the potential hazards of this increasingly popular form of tobacco use...
- Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of ratsGunter Oberdorster
University of Rochester, Department of Environmental Medicine, Rochester, New York 14642, USA
J Toxicol Environ Health A 65:1531-43. 2002..Such translocation to blood and extrapulmonary tissues may well be different between ultrafine carbon and other insoluble (metal) ultrafine particles...
- Nanoparticles for drug delivery to the lungsJean C Sung
Harvard School of Engineering and Applied Sciences, 40 Oxford Street, ESL 406, Cambridge, MA 02138, USA
Trends Biotechnol 25:563-70. 2007..This review covers the development of nanoparticle formulations for pulmonary delivery as both individual nanoparticles and encapsulated within carrier particles...
- Meta-analysis: effects of adding salmeterol to inhaled corticosteroids on serious asthma-related eventsEric Bateman
Division of Pulmonology, Department of Medicine, University of Cape Town, Cape Town, South Africa
Ann Intern Med 149:33-42. 2008..Recent analyses have suggested an increased risk for serious asthma-related adverse events in patients receiving long-acting beta-agonists...
- Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trialShawn D Aaron
The Ottawa Health Research Institute and University of Ottawa, Ottawa, Ontario, Canada
Ann Intern Med 146:545-55. 2007..Treatment of moderate or severe chronic obstructive pulmonary disease (COPD) with combinations of inhaled corticosteroids, long-acting beta-agonists, and long-acting anticholinergic bronchodilators is common but unstudied...
- Impact of two sequential drug cost-sharing policies on the use of inhaled medications in older patients with chronic obstructive pulmonary disease or asthmaColin R Dormuth
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin Ther 28:964-78; discussion 962-3. 2006..Evaluations of drug cost-sharing policies within the same population are needed for a fair comparison of different options...
- Cardiovascular events associated with ipratropium bromide in COPDSarika S Ogale
Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, University of Washington, Seattle, WA, USA
Chest 137:13-9. 2010..We sought to examine the association between ipratropium bromide use and the risk of cardiovascular events (CVEs)...
- Mucus clearance and lung function in cystic fibrosis with hypertonic salineScott H Donaldson
University of North Carolina at Chapel Hill Cystic Fibrosis Research and Treatment Center, Chapel Hill 27599, USA
N Engl J Med 354:241-50. 2006..Through osmotic forces, hypertonic saline may increase the volume of airway surface liquid, restore mucus clearance, and improve lung function...
- The need to improve inhalation technique in Europe: a report from the Aerosol Drug Management Improvement TeamG K Crompton
Respiratory Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland, UK
Respir Med 100:1479-94. 2006..There is also a need for standardisation of prescribing practices throughout Europe. Regular checking of inhalation technique by prescribers is crucial as correct inhalation is one of the keystones of successful asthma management...
- Early aggressive eradication therapy for intermittent Pseudomonas aeruginosa airway colonization in cystic fibrosis patients: 15 years experienceC R Hansen
Department of Pediatrics, 5003, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
J Cyst Fibros 7:523-30. 2008..Since 1989, CF-patients intermittently colonized with Pseudomonas aeruginosa have been treated with inhaled colistin and oral ciprofloxacin in the Copenhagen CF-centre. The study evaluates 15 years results of this treatment...
- Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstrictionC Frostell
Department of Anesthesia, Harvard Medical School, Massachusetts General Hospital, Boston
Circulation 83:2038-47. 1991..Conclusions. Low dose inhaled NO (5-80 ppm) is a selective pulmonary vasodilator reversing both hypoxia- and thromboxane-induced pulmonary hypertension in the awake lamb [corrected]...
- Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trialThérèse S Lapperre
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
Ann Intern Med 151:517-27. 2009..Inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs) are used to treat moderate to severe chronic obstructive pulmonary disease (COPD)...
- Spirometric correlates of improvement in exercise performance after anticholinergic therapy in chronic obstructive pulmonary diseaseD E O'Donnell
Respiratory Investigation Unit, Departments of Medicine and Community Health and Epidemiology, Queen s University, Kingston, Ontario, Canada
Am J Respir Crit Care Med 160:542-9. 1999..IC should be used in conjunction with FEV(1) when evaluating therapeutic responses in COPD...
- Inhaled iloprost for severe pulmonary hypertensionHorst Olschewski
Department of Internal Medicine II, University Clinic, Giessen, Germany
N Engl J Med 347:322-9. 2002..Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and exercise capacity in patients with pulmonary hypertension...
- Nitrogen dioxide promotes allergic sensitization to inhaled antigenMieke Bevelander
Vermont Lung Center, University of Vermont, Burlington, VT 05405, USA
J Immunol 179:3680-8. 2007..These findings offer a mechanism whereby allergen sensitization and asthma may result under conditions of high ambient or endogenous NO2 levels...
- Chronically inhaled salmeterol improves pulmonary function in heart failureTien M H Ng
Department of Pharmacy Practice, University of Utah Health Sciences Center, Salt Lake City, UT, USA
J Cardiovasc Pharmacol 40:140-5. 2002..The plasma half-life of salmeterol may be prolonged in heart failure patients, thus leading to accumulation at steady-state...
- Inhaled beta2-adrenoceptor agonists: cardiovascular safety in patients with obstructive lung diseaseMario Cazzola
Unit of Pneumology and Allergology, Department of Respiratory Medicine, Cardarelli Hospital, Naples, Italy
Drugs 65:1595-610. 2005..Therefore, beta(2)-agonists must always be used with caution in patients with cardiopathies because these agents may precipitate the concomitant cardiac disease...
- Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthmaG W Chalmers
Departments of Respiratory Medicine and Immunology, Western Infirmary, Glasgow G11 6NT, UK
Thorax 57:226-30. 2002..A study was undertaken to investigate the effect of active cigarette smoking on responses to treatment with inhaled corticosteroids in patients with mild asthma...
- Potential adverse effects of the inhaled corticosteroidsH William Kelly
Department of Pediatrics, University of New Mexico Children s Hospital, ACC Building 3rd Floor, 2211 Lomas Boulevard NE, Albuquerque, NM 87131 5311, USA
J Allergy Clin Immunol 112:469-78; quiz 479. 2003..The data are insufficient to determine whether there is an effect on attainment of predicted adult height. The ICSs affect bone mineral density and risk of fractures in a dose-dependent fashion that appears significant at high doses...
- Adherence to asthma controller medication regimensD A Stempel
Department of Pediatrics, Infomed Northwest and University of Washington, Bellevue, WA 98004, USA
Respir Med 99:1263-7. 2005....
- Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroidsJ C Virchow
Department of Pneumology, University Medical Clinic Freiburg, Germany and AstraZeneca Pharmaceuticals, Macclesfield, United Kingdom
Am J Respir Crit Care Med 162:578-85. 2000....
- Salmeterol, a beta2-receptor agonist, attenuates lipopolysaccharide-induced lung inflammation in miceNico A Maris
Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Am J Physiol Lung Cell Mol Physiol 286:L1122-8. 2004..These data suggest that salmeterol inhibits lipopolysaccharide-induced neutrophil recruitment to the lungs by a mechanism that possibly in part is mediated by an effect on neutrophil CD11b...
- Capsaicin inhalation test for identification of sensory hyperreactivityA Johansson
Allergy Centre, Central Hospital, Skovde, Sweden
Respir Med 96:731-5. 2002..However, these patients have been found to be more sensitive to inhalation of capsaicin than healthy people. The aim of this study was to establish limit values with the capsaicin inhalation test in patients with SHR...
- Management of stable chronic obstructive pulmonary disease: a systematic review for a clinical practice guidelineTimothy J Wilt
Minnesota Agency for Healthcare Research and Quality Evidence based Practice Center, Minneapolis Veterans Affairs Medical Center, and University of Minnesota, Minneapolis, Minnesota 55417, USA
Ann Intern Med 147:639-53. 2007....
- Risk of mortality and heart failure exacerbations associated with inhaled beta-adrenoceptor agonists among patients with known left ventricular systolic dysfunctionDavid H Au
Health Services Research and Development, Northwest Center of Excellence, VA Puget Sound Health Care System, Department of Veterans Affairs, Seattle, WA 98108, USA
Chest 123:1964-9. 2003..We sought to determine if use of selective beta(2)-agonists was associated with hospitalization for heart failure and all-cause mortality...
- Use of carbon monoxide as a therapeutic agent: promises and challengesRoberta Foresti
Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, HA1 3UJ, Harrow, Middlesex, UK
Intensive Care Med 34:649-58. 2008....
- Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in ratsDavid C Dorman
CIIT Centers for Health Research, Research Triangle Park, NC 27709 2137, USA
Toxicol Appl Pharmacol 197:113-24. 2004..Data from this study should prove useful in developing dosimetry models for manganese that consider age or gender as potential sensitivity factors...
- Fluticasone propionate/salmeterol hydrofluoroalkane via metered-dose inhaler with integrated dose counter: Performance and patient satisfactionK Sheth
Lafayette Allergy and Asthma Clinic, Lafayette, IN 47905, USA
Int J Clin Pract 60:1218-24. 2006..This integrated MDI counter may help patients maintain better disease control by enabling them to accurately track their medication supply...
- A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasisPaul Scheinberg
Atlanta Pulmonary Group, 5667 Peachtree Dunwoody Rd, Suite 350, Atlanta, GA 30350, USA
Chest 127:1420-6. 2005..To evaluate the efficacy and safety of tobramycin solution for inhalation (TSI) in patients with severe bronchiectasis...
- The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the ratJames G Martin
Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec, Canada
J Immunol 169:3963-9. 2002..We conclude that PGE(2) is a potent anti-inflammatory agent that may act by reducing allergen-induced Th2 cell activation and cysteinyl-leukotriene synthesis in the rat...
- Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthmaH Derendorf
Dept of Pharmaceutics, University of Florida, 100494 College of Pharmacy, Gainesville, FL 32610, USA
Eur Respir J 28:1042-50. 2006....
- A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthmaJean Bousquet
Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, France
Clin Ther 24:1-20. 2002..Although inhaled corticosteroids (ICS) are commonly used in the treatment of persistent asthma, the relationship between dose and clinical response remains unclear...
- Risk of pneumonia associated with long-term use of inhaled corticosteroids in chronic obstructive pulmonary disease: a critical review and updateSonal Singh
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Curr Opin Pulm Med 16:118-22. 2010....
- Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: a systematic review and a meta-analysisWen Qi Gan
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital and the Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
BMC Pulm Med 5:3. 2005..We sought to determine the effects of inhaled corticosteroids on sputum indices of inflammation in stable COPD...
- Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristicsAnthony J Hickey
Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina, Campus Box 7360, 1310 Kerr Hall, Kerr Hall, Chapel Hill, North Carolina 27599 7360, USA
J Pharm Sci 96:1282-301. 2007..This is the first of two papers that discuss static and dynamic methods of characterizing dry powder inhaler formulations...
- Nanoparticle formulations in pulmonary drug deliveryMark M Bailey
Department of Chemical and Petroleum Engineering, The University of Kansas, Lawrence, KS 66047, USA
Med Res Rev 29:196-212. 2009..Here, the benefits of nanoparticle formulations and current progress are compared in light of the practical encumbrances of producing formulations, and possible toxicological effects of these materials...
- Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trialRudolf A Baumgartner
Sepracor Inc, Marlborough, Massachusetts 01752, USA
Clin Ther 29:261-78. 2007....
- Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysisM Bradley Drummond
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
JAMA 300:2407-16. 2008..Recent studies of inhaled corticosteroid (ICS) therapy for managing stable chronic obstructive pulmonary disease (COPD) have yielded conflicting results regarding survival and risk of adverse events...
- Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone : a cross-over study in healthy volunteersChet L Leach
3M Pharmaceuticals, St Paul, MN, USA
Chest 122:510-6. 2002..To compare the lung deposition of radiolabeled hydrofluoroalkane-134a beclomethasone dipropionate (HFA-BDP) with chlorofluorocarbon fluticasone propionate (CFC-FP) and chlorofluorocarbon beclomethasone (CFC-BDP)...
- CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammationLidia Michalec
National Institutes of Health Asthma and Allergic Diseases Research Center and Department of Internal Medicine and Department Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA
J Immunol 168:846-52. 2002..These observations may have relevance in induction of neutrophilia in severe asthma...
- Use of exhaled nitric oxide measurements to guide treatment in chronic asthmaAndrew D Smith
Respiratory Research Unit, Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
N Engl J Med 352:2163-73. 2005..Measurements of the fraction of exhaled nitric oxide (FE(NO)) constitute a noninvasive marker that may be a useful alternative for the adjustment of inhaled-corticosteroid treatment...
- Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot studyE Bathoorn
Dept of Pulmonology, Groningen Research Instsitute for Asthma and COPD, The Netherlands
Eur Respir J 30:1131-7. 2007..Further studies need to confirm the safety and efficacy in inflammatory lung diseases...
- Outcomes associated with tiotropium use in patients with chronic obstructive pulmonary diseaseTodd A Lee
Center for Management of Complex Chronic Care, Edward Hines Jr VA Hospital, Hines, Illinois, USA
Arch Intern Med 169:1403-10. 2009..Our objective was to evaluate the comparative effectiveness of regimens containing tiotropium bromide vs other medication regimens for chronic obstructive pulmonary disease (COPD) in real-world clinical settings...
- Randomised controlled trial of montelukast plus inhaled budesonide versus double dose inhaled budesonide in adult patients with asthmaD B Price
Department of General Practice and Primary Care, University of Aberdeen, Foresterhill Health Centre, Westburn Road, Aberdeen AB25 2AY, Scotland, UK
Thorax 58:211-6. 2003..This double blind, randomised, parallel group, non-inferiority, multicentre 16 week study compared the clinical benefits of adding montelukast to budesonide with doubling the budesonide dose in adults with asthma...
- Long-term inhaled corticosteroids in preschool children at high risk for asthmaTheresa W Guilbert
Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
N Engl J Med 354:1985-97. 2006..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma...
- Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosisH Olschewski
Depatment of Internal Medicine II, Justus Liebig University, Giessen, Germany
Am J Respir Crit Care Med 160:600-7. 1999..Long-term therapy with inhaled iloprost may be life saving in decompensated right heart failure from pulmonary hypertension secondary to lung fibrosis...
- Effect of montelukast added to inhaled budesonide on control of mild to moderate asthmaM J Vaquerizo
Merck Sharp and Dohme, c Josefa Valcarcel 38, 28027 Madrid, Spain
Thorax 58:204-10. 2003..A 16 week multicentre, randomised, double blind, controlled study was undertaken to study the efficacy of adding oral montelukast, a leukotriene receptor antagonist, to a constant dose of inhaled budesonide...
- Inhaled corticosteroids: past lessons and future issuesDavid B Allen
Division of Endocrinology, University of Wisconsin Children s Hospital, Madison 53792 4108, USA
J Allergy Clin Immunol 112:S1-40. 2003....
- Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysisB J Lipworth
Department of Clinical Pharmacology and Therapeutics and Respiratory Medicine, Ninewells Hospital and Medical School, University of Dundee, Scotland
Arch Intern Med 159:941-55. 1999..To appraise the data on systemic adverse effects of inhaled corticosteroids...
- Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertensionH Wilkens
Medizinische Klinik und Poliklinik, Innere Medizin V, Innere Medizin III, Homburg Saar, Germany
Circulation 104:1218-22. 2001..However, repetitive inhalations are required due to its short-term effects. One potential approach to prolong and increase the vasorelaxant effects of aerosolized iloprost might be to combine use with phosphodiesterase inhibitors...
- Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic miceBarbro N Melgert
Department of Pathology and Laboratory Medicine, University Hospital Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
Am J Respir Cell Mol Biol 30:880-5. 2004..This effect of smoking may be different for long-term smoking, in which remodeling effects of smoking can be expected to interrelate with remodeling changes caused by asthmatic disease...
- Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent wayLander J Robays
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
J Immunol 183:2758-66. 2009..The TLR independency of this phenomenon suggests that alternative immunological adjuvants are present in cigarette smoke...
- Methods for therapeutic trials in COPD: lessons from the TORCH trialO N Keene
GlaxoSmithKline Research and Development, Stockley Park, 1 3 Iron Bridge Road, Uxbridge, Middlesex UB11 1BU, UK
Eur Respir J 34:1018-23. 2009..No definitive conclusions can yet be drawn on whether ICS treatment has an effect on mortality...
- Adherence with montelukast or fluticasone in a long-term clinical trial: results from the mild asthma montelukast versus inhaled corticosteroid trialCynthia Rand
Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
J Allergy Clin Immunol 119:916-23. 2007..Nonadherence with asthma therapy is common and may contribute to poor clinical outcomes...
- Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trialDennis E Niewoehner
Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Ann Intern Med 143:317-26. 2005..Patients with chronic obstructive pulmonary disease (COPD) frequently develop exacerbations, leading to major clinical and health resource use ramifications...
- Higher patient perceived side effects related to higher daily doses of inhaled corticosteroids in the community: a cross-sectional analysisJuliet M Foster
Department of General Practice and Primary Care, University of Aberdeen, Foresterhill AB25 2AY, Scotland
Respir Med 100:1318-36. 2006..The range and extent of inhaled corticosteroid (ICS) side effects experienced by patients in the general community are likely to be underestimated...
- Lung surfactant as a drug delivery systemC Vermehren
Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
Int J Pharm 307:89-92. 2006..This study suggests that HL10 may be a promising drug delivery system for the pulmonary delivery of amphipathic drug substances, e.g. therapeutically active acylated peptides (e.g. acylated insulin)...
- A comparison of budesonide/formoterol maintenance and reliever therapy vs. conventional best practice in asthma managementR Louis
Pneumology, CHU Sart Tilman, Liege, Belgium
Int J Clin Pract 63:1479-88. 2009....
- Inhalation administration of all-trans-retinoic acid for treatment of elastase-induced pulmonary emphysema in Fischer 344 ratsThomas H March
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108 5127, USA
Exp Lung Res 30:383-404. 2004....
- Genomic analysis of the rat lung following elemental mercury vapor exposureJie Liu
Inorganic Carcinogenesis Section, NCI at NIEHS, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 74:174-81. 2003..In summary, genomic analysis revealed an array of gene alterations in response to Hg0 vapor exposure, which could be important for the development of pulmonary adaptation to Hg during Hg0 vapor inhalation...
- Formoterol and salmeterol in partially reversible chronic obstructive pulmonary disease: A crossover, placebo-controlled comparison of onset and duration of actionG Celik
Department of Chest Diseases, Ankara University Faculty of Medicine, Ankara, Turkey
Respiration 66:434-9. 1999..In contrast to the well-known activity profile in asthma, the precise efficacy and optimum dose schedules of long-acting beta(2)-agonists in chronic obstructive pulmonary disease (COPD) are not clear...
- Lung deposition of formoterol HFA (Atimos/Forair) in healthy volunteers, asthmatic and COPD patientsSabine Häussermann
Inamed Research GmbH and Co KG, Robert Koch Allee 29, 82131 Gauting, Germany
J Aerosol Med 20:331-41. 2007..8 microm) of the HFA-Formoterol-Formulation and the slow inhalation (30 L/min flow) used in this study. It can be concluded, that with this modern HFA drug formulation, the deposition is high, even in obstructed lungs...
- Effect of formoterol with or without budesonide in repeated low-dose allergen challengeB Dahlen
Division of Respiratory Medicine and Allergy, Dept of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
Eur Respir J 33:747-53. 2009..Signs of deteriorating asthma, provoked by low-dose allergen, are prevented by short-term use of budesonide/formoterol but not by temporary use of formoterol alone...
- Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigenHendrik Jan de Heer
Department of Pulmonary Medicine, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, Netherlands
J Exp Med 200:89-98. 2004..These studies show that pDCs provide intrinsic protection against inflammatory responses to harmless antigen. Therapies exploiting pDC function might be clinically effective in preventing the development of asthma...
- Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary diseaseDonald A Mahler
Dartmouth Hitchcock Medical Center, Section of Pulmonary and Critical Care Medicine, 1 Medical Center Drive, Lebanon, NH 03756 0001, USA
Am J Respir Crit Care Med 166:1084-91. 2002..We conclude that FSC improved lung function and reduced the severity of dyspnea compared with individual components and placebo...
- The CFC to HFA transition and its impact on pulmonary drug developmentChet L Leach
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
Respir Care 50:1201-8. 2005..The transition from CFCs also spurred novel new drug-delivery technologies, improved dry powder inhalers, and highly dispersible engineered powders...
- Asymptomatic worsening of airway inflammation during low-dose allergen exposure in asthma: protection by inhaled steroidsJosephine de Kluijver
Department of Pulmonology, Lung Function Laboratory, C2 P 62 Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, The Netherlands
Am J Respir Crit Care Med 166:294-300. 2002..This suggests that antiinflammatory therapy is beneficial during allergen exposure, even during asymptomatic episodes...
- Exaggerated airway narrowing in mice treated with intratracheal cationic proteinJason H T Bates
Vermont Lung Center, University of Vermont College of Medicine, Burlington, VT 05405 0075, USA
J Appl Physiol (1985) 100:500-6. 2006....
- Inhaling medicines: delivering drugs to the body through the lungsJohn S Patton
Nektar Therapeutics, 150 Industrial Road, San Carlos, California 94070, USA
Nat Rev Drug Discov 6:67-74. 2007..Here, we review these advances, and discuss aspects of lung physiology and formulation composition that influence the systemic delivery of inhaled therapeutics...
- Regulation of dendritic cell recruitment into resting and inflamed airway epithelium: use of alternative chemokine receptors as a function of inducing stimulusP A Stumbles
TVW Telethon Institute for Child Health Research, and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
J Immunol 167:228-34. 2001....
- A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosisMark R Elkins
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia
N Engl J Med 354:229-40. 2006..Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-term trials, improves lung function in people with cystic fibrosis. We tested the safety and efficacy of inhaled hypertonic saline in a long-term trial...
- Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjectsJohn D Brannan
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
Respirology 7:37-44. 2002..The aim of the study was to investigate whether treatment using inhaled corticosteroids decreases airway responsiveness to inhaled mannitol in asthmatic subjects...
- Addition of salmeterol to low-dose fluticasone versus higher-dose fluticasone: an analysis of asthma exacerbationsJ Matz
Atlantic Asthma and Allergy Center, Inc, Baltimore, MD, USA
J Allergy Clin Immunol 107:783-9. 2001..The ability to detect deteriorating asthma and the severity of exacerbation was similar between groups...
- Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cellsPaul R Knight; Fiscal Year: 2010..well suited for these treatment strategies as direct contact with the environment provides a portal for inhalation administration of cDNA and siRNA conjugated nanoplexes...
- Quantitative MRI-based Assessment of Aerosol Deposition in the LungChantal Darquenne; Fiscal Year: 2009..The technique developed in the proposed research will also enable future MRI studies of numerous different lung disease models. ..
- Inhalable amphotericin B nanodisk therapy for pulmonary aspergillosisTrudy Forte; Fiscal Year: 2005..fumigatus infection. We will examine the overall suitability of ND-AMB for inhalation administration, specifically, ND-AMB compatibility with inhaleable dry powder synthesis and the ability of ND-AMB to ..
- TOXICITY AND CARCINOGENICITY TESTS OF ACETONITRILEHARVEY RAGAN; Fiscal Year: 1992..The results of the 2-year chronic study will be used by NTP to determine toxicologic and carcinogenic effects of inhalation administration of acetonitrile.
- INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASEJohn Kinsella; Fiscal Year: 2004..This study design also allows for insights into the role of inflammatory markers in prediction of CLD risk in the premature newborn. ..
- Aerosolized PGE1 in Neonatal Pulmonary HypertensionBEENA SOOD; Fiscal Year: 2005..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
- Self-administration of abused inhalants in miceScott Bowen; Fiscal Year: 2004....
- Behavioral Effects of Gestational Inhalant Abuse in RatsScott Bowen; Fiscal Year: 2006..Finally, this research has the potential to assist in the design of effective treatments for inhalant abuse. [unreadable] [unreadable]..
- A Preclinical Model of Adolescent Toluene Abuse in RatsScott Bowen; Fiscal Year: 2005..The model also has the potential to assist in devising effective treatments and prevention strategies for adolescent inhalant abuse. ..
- CALORIC RESTRICTION, AGING, AND INSULIN ACTIONWilliam Cefalu; Fiscal Year: 2001....
- USING INFORMATION TECHNOLOGY TO IMPROVE ASTHMA ADHERENCEKeoki Williams; Fiscal Year: 2008..abstract_text> ..
- MECHANISMS OF RESPONSE TO PULMONARY VACCINATIONAnthony Hickey; Fiscal Year: 2005..The significance of this work lies in the novelty of pulmonary vaccination for the treatment of tuberculosis and the knowledge of the immune response gained from targeted antigen delivery to the lungs. ..
- Mechanism of Endotoxin's Effect On Allergy RiskKeoki Williams; Fiscal Year: 2008..It is the hoped that understanding the mechanism of endotoxin's effect will establish new targets for the prevention of allergies. ..
- CONTROL OF IGE MEDIATED PULMONARY INFLAMMATION IN HUMANSStephen Peters; Fiscal Year: 2001....
- TLR's, Nitric Oxide and Chronic Lung DiseaseWilliam Truog; Fiscal Year: 2005..Its results may also open up intriguing pathways for treatments aimed at selective diminution of pulmonary inflammation. ..
- Chromium, Cellular Energy Status and Whole Body Energy BalanceWilliam Cefalu; Fiscal Year: 2007..abstract_text> ..
- ASTHMA CLINICAL RESEARCH NETWORK (ACRN)Stephen Peters; Fiscal Year: 2007....
- THE CLINICAL EFFECTIVENESS OF PHARMACY ADHERENCE INFORMATION FOR DIABETES CONTROLKeoki Williams; Fiscal Year: 2010..Analyses will control for cluster randomization effects. The introduction of sustainable medication adherence monitoring in clinical practice holds great potential to improve health outcomes among patients with diabetes. ..
- HORMONE REPLACEMENT FOR PREVENTION OF VISCERAL OBESITYWilliam Cefalu; Fiscal Year: 2002....
- Chromium and Insulin ActionWilliam Cefalu; Fiscal Year: 2006..abstract_text> ..
- A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERWilliam Coryell; Fiscal Year: 2007..Analysis of the existing sib pair families plus this large set of cases and controls should permit the confirmation of several vulnerability genes during this grant period. ..
- Temporal Integration in Nasal LateralizationPaul Wise; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- VEGF and Nitric Oxide in Lung Vascular DevelopmentVivek Balasubramaniam; Fiscal Year: 2007..In addition, Dr. Balasubramaniam will continue to work with Dr. Charles Plopper (UC Davis) to learn more sophisticated techniques of morphometric analysis. ..
- Treatment of Severe Persistent AsthmaROBERT LEMANSKE; Fiscal Year: 2007..abstract_text> ..
- Prospective Study of Dietary Factors, BMI, and Risk of Asthma in ChildrenCarlos Camargo; Fiscal Year: 2008..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of asthma. [unreadable] [unreadable] [unreadable] [unreadable]..
- Genetics of Early-Onset DepressionWilliam Coryell; Fiscal Year: 2008..abstract_text> ..
- COLLABORATIVE DEPRESSION STUDYWilliam Coryell; Fiscal Year: 2008..unreadable] [unreadable]..
- MECHANICS OF ACUTE LUNG INJURYJason Bates; Fiscal Year: 2009..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..
- Assessment of Lung function in MiceJason Bates; Fiscal Year: 2009....
- Monitoring transplant kidney function with MRISEAN BEDILION FAIN; Fiscal Year: 2010....
- Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage FunctionAnne Fitzpatrick; Fiscal Year: 2009..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
- Regulation and role of CEACAM6 in the lung alveolusPhilip L Ballard; Fiscal Year: 2011..The studies of this project will examine expression and function of the protein in normal lung and its role in response to lung injury and infection. ..
- Prospective Study of Diet, Physical Activity, BMI and Risk of Pulmonary EmbolismCarlos Camargo; Fiscal Year: 2008..We believe that quantifying these modifiable risk factors will lead to public health interventions that decrease the incidence of pulmonary embolism in the elderly population. [unreadable] [unreadable] [unreadable]..
- Response to Beta2-Agonists in Acute Severe AsthmaNicola Hanania; Fiscal Year: 2008..abstract_text> ..
- Distal Lung Inflammation Effect on Asthma ExacerbationsDonald Tashkin; Fiscal Year: 2008..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
- Marijuana use patterns: Temporal change in predictors, perceptions, and ad impactWILLIAM CRANO; Fiscal Year: 2008..abstract_text> ..
- CARE Network - Madison Clinical CenterROBERT LEMANSKE; Fiscal Year: 2008..abstract_text> ..
- Childhood Asthma Research and Education Network: Denver SiteStanley Szefler; Fiscal Year: 2008..End of abstract.) [unreadable] [unreadable]..
- Effectiveness of the TB Contact Priority ModelWilliam Bailey; Fiscal Year: 2008..unreadable] [unreadable]..
- Obesity, Inflammation and Response to Therapy in AsthmaEVERETT RAND SUTHERLAND; Fiscal Year: 2010..End of Abstract) ..
- Development of Therapeutic Inhibitors to Anthrax ToxinsJOHNNY PETERSON; Fiscal Year: 2006..anthracis, increase the efficacy of antibiotics, promote killing of the bacteria by phagocytes, and enhance vaccine-induced immunity. [unreadable] [unreadable]..
- ASTHMA CLINICAL RESEARCH NETWORKROBERT LEMANSKE; Fiscal Year: 2002....
- Determinants of Tolerance to Nitrous Oxide HypothermiaKarl Kaiyala; Fiscal Year: 2004..These studies have theoretical importance for understanding the mechanisms of drug tolerance and will begin to suggest the physiological basis of individual differences in vulnerability to addiction and drug abuse. ..
- ASSESSMENT MODE AND VALIDITY OF SELF-REPORTS IN CHILDRENBruce Bender; Fiscal Year: 2004..Results from this investigation are expected to have immediate and direct implication for clinical research in asthma and with other chronic conditions. ..
- TRAIT MARKER FOR PANIC DISORDERWilliam Coryell; Fiscal Year: 2001..If the study's predictions are sustained, subsequent efforts will be directed toward lengthening the follow-up period and toward an eventual, ten-year diagnostic reassessment. ..
- SCLERODERMA LUNG STUDYDonald Tashkin; Fiscal Year: 2003..abstract_text> ..
- GAS EXCHA03NGE IMAGING IN THE LUNG USING MRISamuel Patz; Fiscal Year: 2001..Early detection of the loss of alveolar surface area is a serious public health imperative, since chronic obstructive pulmonary disease is now the Th leading cause of death in the US. ..
- Adherence & Treatment Outcome in Adolescents in CAMPCSBruce Bender; Fiscal Year: 2003..abstract_text> ..
- PREOPERATIVE TREATMENT OF LUNG CANCER WITH rhuMab VEGFGregory Otterson; Fiscal Year: 2003..Careful comparison/analysis of clinical and biologic information gathered in this study will likely enhance our understanding of tumor growth and progression as well as response to therapy. ..
- DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASECarlos Camargo; Fiscal Year: 2002..The proposed study is cost-effective, as it makes use of an existing cohort, and it will provide information that could have direct clinical application to reduce risk of COPD. ..
- LUNG HEALTH STUDY--LONG TERM FOLLOW UPDonald Tashkin; Fiscal Year: 2002..All ten of the original LHS clinical centers plan to participate in this study. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
- ROLE OF ENDOTHELIN IN PERINATAL PULMONARY VASOREGULATIONDAVID IVY; Fiscal Year: 2002..Research presentations along with graduate level courses in molecular biology, and the clinical ambiance of the Univ of CO SOM in the area of pulmonary hypertension enhance career development. ..
- CYTOKINE DYSREGULATION, VIRUSES, AND CHILDHOOD ASTHMAROBERT LEMANSKE; Fiscal Year: 2001..The results of these studies will provide information that will be a major step forward in our understanding of the relative influence that genetic and environmental risk factors on the development of childhood asthma. ..
- Infrastructure and Applications of Hyperpolarized 129XeSamuel Patz; Fiscal Year: 2006..A polarizer will be built, sited and supported at Brigham and Women's Hospital. Animal and human studies are proposed to demonstrate the structural and functional information 129Xe MRI can provide. ..
- Reducing Inhalant Use in Young AdolescentsWILLIAM CRANO; Fiscal Year: 2005..It is hypothesized that messages focusing on social identity will be most effective in this population--especially if delivered by a peer source. ..
- IMMUNE MECHANISMS OF MIDDLE EAR DISEASEDavid Skoner; Fiscal Year: 2006..The primary hypothesis is that cytokine genotype is predictive of illness expression and of OM incidence during a documented RSV infection in young children. ..
- Neuroadaptive Substrates for Nitrous Oxide ToleranceKarl Kaiyala; Fiscal Year: 2006..This work will be the first to identify brain areas activated by a drug-induced hypothermic stimulus and its adaptive consequences. These studies have theoretical importance for understanding and treating drug addiction. ..
- New Mechanisms in the Pathogenesis of CholeraJOHNNY PETERSON; Fiscal Year: 2006..Although CTs action is a multifaceted mechanism, therapeutic control of CT- induced hypersecretion of water and electrolytes in cholera may be possible by modulating AA metabolism. ..
- CONFERENCE ON PARTICULATE AIR POLLUTION AND HUMAN HEALTHRobert Phalen; Fiscal Year: 2003..To add significantly to the peer-reviewed literature by publishing research results presented at the conference in a variety of special issues of selected journals. ..
- Computerized ASI Follow-up and Outcome SystemStephen Butler; Fiscal Year: 2004..Client acceptance will be evaluated along with correspondence between the IVR and traditional ASI administration. Phase II will evaluate the system's validity, capacity to produce acceptable response rates, and cost-effectiveness. ..
- ASI-MV.net: A Prescription Medication Monitoring ToolStephen Butler; Fiscal Year: 2006..Phase II will fully develop the ASI-MV.net website and establish its reliability and validity. The ASI-MV.net will be an innovative solution to problems collecting product-specific addictions data in real time. [unreadable] [unreadable]..
- EXPERIMENTAL TESTING OF THE DESIGNATED DRIVER CONCEPTJames Lange; Fiscal Year: 2003..Further, the methods used will recruit whole groups, so that these trials will offer an opportunity to study the effects of a designated driver on the results of passengers' BACs. ..
- A Chinese Adaptation of the ASI-Multimedia VersionStephen Butler; Fiscal Year: 2004..The final product will be marketed as part of our extensive suite of substance abuse-related, multimedia tools. ..
- Internet Monitoring Of Prescription Drug AbuseStephen Butler; Fiscal Year: 2006..Phase II will see development of a full prototype of PRISM and demonstration of its reliability and internal and external validity. [unreadable] [unreadable] [unreadable] [unreadable]..
- SCHOOL BASED DRUG PREVENTION PROGRAMChristopher Ringwalt; Fiscal Year: 2001....
- COMMUNITY PARTNERSHIP TO REDUCE ASTHMA DISPARITIESElizabeth McQuaid; Fiscal Year: 2009..A Sustainability Advisory board will provide guidance regarding project implementation in the community beyond the life of the grant. ..
- MECHANISMS REGULATING AIRWAY MUSCLE GROWTHReynold Panettieri; Fiscal Year: 2003..These studies will define the mechanism by which agonists induce ASM cell growth such that new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
- Mechanisms of VEGF modulation of smooth muscle functionReynold Panettieri; Fiscal Year: 2009..abstract_text> ..
- Ozone ALTERS Airway Smooth Muscle FUNCTION IN ASTHMAReynold Panettieri; Fiscal Year: 2008..These studies will identify the mechanisms by which ozone enhances allergen-induced AHR and provide insight into new therapeutic targets to prevent asthma exacerbations and decrease asthma morbidity and mortality. ..
- MECHANISMS OF SMOOTH MUSCLE HYPERREACTIVITY ON ASTHMAPrescott Woodruff; Fiscal Year: 2006..The candidate will complement these studies with a curriculum of advanced training in methods for the design and analysis of gene expression studies in human subjects. ..
- Mechanisms Regulation Functions of Airway Smooth MuscleReynold Panettieri; Fiscal Year: 2007..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..
- TESTING INTERVENTIONS IN PEDIATRIC ASTHMAElizabeth McQuaid; Fiscal Year: 2002..Exploratory analyses will investigate mediators of behavior change. Results will be used to design a larger, randomized controlled trial comparing behavioral feedback to asthma education. ..
- T CELL INFLAMMATION AND MUCIN HYPERSECRETION IN COPDJohn Fahy; Fiscal Year: 2004..abstract_text> ..
- Promoting Fidelity Using Remote and Onsite SupportChristopher Ringwalt; Fiscal Year: 2006..Study results will inform the prevention field concerning the potential for personalized coaching and technical assistance to promote curriculum fidelity and affect key student-level mediating variables. ..