Genomes and Genes
Summary: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. A cell culture facility is required for cell harvest and expansion.
Publications334 found, 100 shown here
- Adipose-derived stem cells for regenerative medicineJeffrey M Gimble
Stem Cell Biology Laboratory and Clinical Nutrition Research Unit, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Circ Res 100:1249-60. 2007..The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article...
- Control of stem cell fate by physical interactions with the extracellular matrixFarshid Guilak
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Cell Stem Cell 5:17-26. 2009..Here, we review some of the physical processes by which cues from the ECM can influence stem cell fate, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.
- Adult mesenchymal stem cells for tissue engineering versus regenerative medicineArnold I Caplan
Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
J Cell Physiol 213:341-7. 2007..The MSCs have been used in preclinical models for tissue engineering of bone, cartilage, muscle, marrow stroma, tendon, fat, and other connective tissues...
- Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineeringM P Lutolf
Integrative Biosciences Institute, Ecole Polytechnique Federale de Lausanne EPFL, Building AA B 039, CH 1015 Lausanne, Switzerland
Nat Biotechnol 23:47-55. 2005....
- Porosity of 3D biomaterial scaffolds and osteogenesisVassilis Karageorgiou
Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Biomaterials 26:5474-91. 2005..New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs...
- Corneal reconstruction with tissue-engineered cell sheets composed of autologous oral mucosal epitheliumKohji Nishida
Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
N Engl J Med 351:1187-96. 2004..We studied the use of autologous oral mucosal epithelial cells as a source of cells for the reconstruction of the corneal surface...
- Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineeringK Rezwan
Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK
Biomaterials 27:3413-31. 2006Biodegradable polymers and bioactive ceramics are being combined in a variety of composite materials for tissue engineering scaffolds...
- Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heartHarald C Ott
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
Nat Med 14:213-21. 2008..By day 8, under physiological load and electrical stimulation, constructs could generate pump function (equivalent to about 2% of adult or 25% of 16-week fetal heart function) in a modified working heart preparation...
- Decellularization of tissues and organsThomas W Gilbert
McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
Biomaterials 27:3675-83. 2006Decellularized tissues and organs have been successfully used in a variety of tissue engineering/regenerative medicine applications, and the decellularization methods used vary as widely as the tissues and organs of interest...
- Exploring and engineering the cell surface interfaceMolly M Stevens
Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology, and Medicine, Prince Consort Road, London SW7 2BP, UK
Science 310:1135-8. 2005..Far-reaching implications are emerging for applications including medical implants, cell supports, and materials that can be used as instructive three-dimensional environments for tissue regeneration...
- Engineering cartilage tissueCindy Chung
Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 S 33rd Street, Philadelphia, PA 19104, USA
Adv Drug Deliv Rev 60:243-62. 2008Cartilage tissue engineering is emerging as a technique for the regeneration of cartilage tissue damaged due to disease or trauma...
- Tissue engineering and regenerative medicine -where do we stand?Raymund E Horch
Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, Friedrich Alexander University Erlangen Nuernberg, Erlangen, Germany
J Cell Mol Med 16:1157-65. 2012b>Tissue Engineering (TE) in the context of Regenerative Medicine (RM) has been hailed for many years as one of the most important topics in medicine in the twenty-first century...
- Nanotechnology in drug delivery and tissue engineering: from discovery to applicationsJinjun Shi
MIT Harvard Center for Cancer Nanotechnology Excellence, Laboratory of Nanomedicine and Biomaterials, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nano Lett 10:3223-30. 2010..Herein, we discuss two important aspects of nanomedicine, drug delivery and tissue engineering, highlighting the advances we have recently experienced, the challenges we are currently facing, and what we ..
- Recent advances in bone tissue engineering scaffoldsSusmita Bose
W M Keck Biomedical Materials Research Lab, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164 2920, USA
Trends Biotechnol 30:546-54. 2012..In this review, we highlight recent advances in bone scaffolds and discuss aspects that still need to be improved...
- Clinical transplantation of a tissue-engineered airwayPaolo Macchiarini
Department of General Thoracic Surgery, Hospital Clinic, Barcelona, Spain
Lancet 372:2023-30. 2008..We aimed to bioengineer tubular tracheal matrices, using a tissue-engineering protocol, and to assess the application of this technology in a patient with end-stage airway disease...
- Tissue-engineered lungs for in vivo implantationThomas H Petersen
Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
Science 329:538-41. 2010..Although representing only an initial step toward the ultimate goal of generating fully functional lungs in vitro, these results suggest that repopulation of lung matrix is a viable strategy for lung regeneration...
- A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cellsW J Wan Ju Li
Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, MD 20892, USA
Biomaterials 26:599-609. 2005The utilization of adult stem cells in tissue engineering is a promising solution to the problem of tissue or organ shortage...
- Electrospinning: applications in drug delivery and tissue engineeringTravis J Sill
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
Biomaterials 29:1989-2006. 2008Despite its long history and some preliminary work in tissue engineering nearly 30 years ago, electrospinning has not gained widespread interest as a potential polymer processing technique for applications in tissue engineering and drug ..
- An overview of tissue and whole organ decellularization processesPeter M Crapo
McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 32:3233-43. 2011..An overview of decellularization methods, their effect upon resulting ECM structure and composition, and recently described perfusion techniques for whole organ decellularization techniques are presented herein...
- Tissue-engineered autologous bladders for patients needing cystoplastyAnthony Atala
Department of Urology and Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Lancet 367:1241-6. 2006..The presence of such segments in the urinary tract has been associated with many complications. We explored an alternative approach using autologous engineered bladder tissues for reconstruction...
- Electrospinning of collagen nanofibersJamil A Matthews
Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298 0551, USA
Biomacromolecules 3:232-8. 2002..The structural, material, and biological properties of electrospun collagen suggest that this material may represent a nearly ideal tissue engineering scaffold.
- Nanotechnological strategies for engineering complex tissuesTal Dvir
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Nanotechnol 6:13-22. 2011b>Tissue engineering aims at developing functional substitutes for damaged tissues and organs...
- Hydrogels for tissue engineering: scaffold design variables and applicationsJeanie L Drury
Department of Biologic and Materials Science, University of Michigan, Room 5210, Ann Arbor, MI 48109, USA
Biomaterials 24:4337-51. 2003Polymer scaffolds have many different functions in the field of tissue engineering. They are applied as space filling agents, as delivery vehicles for bioactive molecules, and as three-dimensional structures that organize cells and ..
- The design of scaffolds for use in tissue engineering. Part I. Traditional factorsS Yang
Design Research Center, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore
Tissue Eng 7:679-89. 2001In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions...
- Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineeringHuanan Wang
Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610064, PR China
Biomaterials 28:3338-48. 2007..All these results indicate that the scaffolds fulfill the basic requirements of bone tissue engineering scaffold, and have the potential to be applied in orthopedic, reconstructive and maxillofacial surgery.
- Self-assembly and mineralization of peptide-amphiphile nanofibersJ D Hartgerink
Department of Materials Science and Engineering, Medical School, Northwestern University, 2225 North Campus Drive, Evanston, IL 60208, USA
Science 294:1684-8. 2001..This alignment is the same as that observed between collagen fibrils and hydroxyapatite crystals in bone...
- Tissue engineered myoblast sheets improved cardiac function sufficiently to discontinue LVAS in a patient with DCM: report of a caseYoshiki Sawa
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka, 565 0871, Japan
Surg Today 42:181-4. 2012..These findings suggest that cellular therapy using myoblast sheets is a promising new strategy for treating patients with end-stage DCM. This method might be an effective alternative to heart transplantation in the near future...
- The impact of PLGA scaffold orientation on in vitro cartilage regenerationYingying Zhang
Department of Plastic and Reconstructive Surgery, Shanghai 9th People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, PR China
Biomaterials 33:2926-35. 2012..These results indicated that the longitudinal microtubular orientation of scaffolds can efficiently improve the structure and function of in vitro engineered cartilage...
- Tracheobronchial transplantation with a stem-cell-seeded bioartificial nanocomposite: a proof-of-concept studyPhilipp Jungebluth
Advanced Center for Translational REGenerative Medicine, Karolinska Institutet, Stockholm, Sweden
Lancet 378:1997-2004. 2011..We report the clinical transplantation of the tracheobronchial airway with a stem-cell-seeded bioartificial nanocomposite...
- Marine polysaccharides: a source of bioactive molecules for cell therapy and tissue engineeringKarim Senni
Seadev FermenSys SAS, Technopole Brest Iroise, France
Mar Drugs 9:1664-81. 2011..Marine polysaccharides present a real potential for natural product drug discovery and for the delivery of new marine derived products for therapeutic applications...
- Designing materials for biology and medicineRobert Langer
Department of Chemical Engineering, Massachusetts Institute of Technology, Building E25 342, Cambridge, Massachusetts 02139, USA
Nature 428:487-92. 2004..These include synthetic replacements for biological tissues, designing materials for specific medical applications, and materials for new applications such as diagnostics and array technologies...
- The role of bioreactors in tissue engineeringIvan Martin
Departments of Surgery and of Research, University Hospital Basel, Hebelstrasse 20, ZLF, Room 405, 4031, Basel, Switzerland
Trends Biotechnol 22:80-6. 2004..In addition, by automating and standardizing tissue manufacture in controlled closed systems, bioreactors could reduce production costs, thus facilitating a wider use of engineered tissues...
- Bone tissue engineering: a review in bone biomimetics and drug delivery strategiesJoshua R Porter
Department of Mechanical Engineering, School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523, USA
Biotechnol Prog 25:1539-60. 2009..biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key ..
- Review: mineralization of synthetic polymer scaffolds for bone tissue engineeringJames D Kretlow
Department of Bioengineering, Rice University, Houston, Texas 77251, USA
Tissue Eng 13:927-38. 2007..Conversely, much work in the field of bone tissue engineering has used composite materials consisting of a mineralized phase or materials designed to mineralize rapidly ..
- Hydrogels as extracellular matrix mimics for 3D cell cultureMark W Tibbitt
Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, USA
Biotechnol Bioeng 103:655-63. 2009..Ultimately, advances in synthetic-biologic hydrogel hybrids are needed to provide robust platforms for investigating cell physiology and fabricating tissue outside of the organism...
- Microporous nanofibrous fibrin-based scaffolds for bone tissue engineeringThanaphum Osathanon
Department of Oral Biology, School of Dentistry, University of Washington, Seattle, WA 98195, United States
Biomaterials 29:4091-9. 2008The fibrotic response of the body to synthetic polymers limits their success in tissue engineering and other applications...
- Adult mesenchymal stem cells and cell-based tissue engineeringRocky S Tuan
National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
Arthritis Res Ther 5:32-45. 2003..bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-based tissue engineering and regeneration...
- Silk-based biomaterialsGregory H Altman
Department of Chemical and Biological Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Biomaterials 24:401-16. 2003..For example, in designing scaffolds for tissue engineering these properties are particularly relevant and recent results with bone and ligament formation in vitro ..
- Mesenchymal stem cells: molecular targets for tissue engineeringNeeraj Kumar Satija
Stem Cell Gene Therapy Research Group, Institute of Nuclear Medicine and Allied Sciences, Timarpur, Delhi, India
Stem Cells Dev 16:7-23. 2007..Their extensive proliferation and transdifferentiation potential makes them best suited for tissue engineering applications...
- Foreign body reaction to biomaterialsJames M Anderson
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, United States
Semin Immunol 20:86-100. 2008..with tissue-engineered constructs containing proteins, cells, and other biological components for use in tissue engineering and regenerative medicine...
- Extracellular matrix as a biological scaffold material: Structure and functionStephen F Badylak
McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Acta Biomater 5:1-13. 2009..from the extracellular matrix (ECM) of intact mammalian tissues have been successfully used in a variety of tissue engineering/regenerative medicine applications both in preclinical studies and in clinical applications...
- Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregatesMark D Ungrin
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 3:e1565. 2008....
- Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffoldsE Sachlos
Department of Materials, University of Oxford, Parks Road, Oxford, OX1 3PH, UK
Eur Cell Mater 5:29-39; discussion 39-40. 2003b>Tissue engineering is a new and exciting technique which has the potential to create tissues and organs de novo. It involves the in vitro seeding and attachment of human cells onto a scaffold...
- Tissue engineering--current challenges and expanding opportunitiesLinda G Griffith
Department of Chemical Engineering, Division of Bioengineering and Environmental Health, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 295:1009-14. 2002b>Tissue engineering can be used to restore, maintain, or enhance tissues and organs...
- Fabrication, characterization and cellular compatibility of poly(hydroxy alkanoate) composite nanofibrous scaffolds for nerve tissue engineeringElahe Masaeli
Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
PLoS ONE 8:e57157. 2013b>Tissue engineering techniques using a combination of polymeric scaffolds and cells represent a promising approach for nerve regeneration...
- Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up studyMartin J Elliott
Department of Cardiothoracic Surgery, Great Ormond Street, Hospital for Children, London, UK
Lancet 380:994-1000. 2012..We describe the case of a child who received a stem-cell-based tracheal replacement and report findings after 2 years of follow-up...
- Third-generation biomedical materialsLarry L Hench
Department of Materials and the Tissue Engineering Centre, Imperial College of Science, Technology and Medicine, University of London, Prince Consort Road, London SW7 2BP, UK
Science 295:1014-7. 2002....
- Microscale technologies for tissue engineering and biologyAli Khademhosseini
Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 103:2480-7. 2006Microscale technologies are emerging as powerful tools for tissue engineering and biological studies...
- Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilageAmilton M Fernandes
The Norwegian Center for Stem Cell Research, University of Oslo, Oslo, Norway
PLoS ONE 8:e62994. 2013..We have isolated chondrocytes from OA joints, performed cell culture expansion and tissue engineering of cartilage using a disc-shaped alginate scaffold and chondrogenic differentiation medium...
- Capturing complex 3D tissue physiology in vitroLinda G Griffith
Biological Engineering Division, Mechanical Engineering Department and Biotech Pharma Engineering Center, Massachusetts Institute of Technology, 16 429, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Nat Rev Mol Cell Biol 7:211-24. 2006The emergence of tissue engineering raises new possibilities for the study of complex physiological and pathophysiological processes in vitro...
- Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineeringChengtie Wu
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People s Republic of China
Biomaterials 33:2076-85. 2012..an important role in stimulating angiogenesis; there are, however, few studies to prepare hypoxia-mimicking tissue engineering scaffolds...
- On the mechanisms of biocompatibilityDavid F Williams
University of Liverpool, UK
Biomaterials 29:2941-53. 2008..This essay then turns its attention to the use of biomaterials in tissue engineering, sophisticated cell, drug and gene delivery systems and applications in biotechnology, and shows that here ..
- Tissue engineering of functional articular cartilage: the current statusLinda Kock
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
Cell Tissue Res 347:613-27. 2012..In addition, the current status of tissue engineering of cartilage will be discussed, with the focus on extracellular matrix content, structure and its ..
- Tissue engineering and regenerative medicine: history, progress, and challengesFrancois Berthiaume
Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
Annu Rev Chem Biomol Eng 2:403-30. 2011The past three decades have seen the emergence of an endeavor called tissue engineering and regenerative medicine in which scientists, engineers, and physicians apply tools from a variety of fields to construct biological substitutes that ..
- Osteogenesis and angiogenesis: the potential for engineering boneJ M Kanczler
Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Developmental Origins of Health and Disease, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD
Eur Cell Mater 15:100-14. 2008..this review, with consideration of how some of these key mechanisms can be combined with new developments in tissue engineering to enable repair and growth of skeletal fractures...
- Combining adult stem cells and polymeric devices for tissue engineering in infarcted myocardiumJean Pierre Karam
LUNAM University, UMR S 1066, F 49933 Angers, France
Biomaterials 33:5683-95. 2012..Scaffold properties required for cardiac cell therapy are here discussed. New tissue engineering advances that may be implemented in combination with adult stem cells for myocardial infarction therapy are ..
- Silk protein fibroin from Antheraea mylitta for cardiac tissue engineeringChinmoy Patra
Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Parkstrasse 1, 61231 Bad Nauheim, Germany
Biomaterials 33:2673-80. 2012..One possible solution to this problem is cardiac tissue engineering. Here, we have investigated the suitability of non-mulberry silk protein fibroin from Indian tropical tasar ..
- High-fidelity tissue engineering of patient-specific auricles for reconstruction of pediatric microtia and other auricular deformitiesAlyssa J Reiffel
Laboratory for Bioregenerative Medicine and Surgery, Division of Plastic Surgery, Weill Cornell Medical College, New York, New York, USA
PLoS ONE 8:e56506. 2013....
- The potential of human fetal mesenchymal stem cells for off-the-shelf bone tissue engineering applicationZhi Yong Zhang
Mechanical Engineering, Faculty of Engineering, National University of Singapore, Singapore
Biomaterials 33:2656-72. 2012Mesenchymal stem cells (MSCs) have become one of the most promising cell sources for bone tissue engineering (BTE) applications...
- The extracellular matrix as a biologic scaffold materialStephen F Badylak
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA
Biomaterials 28:3587-93. 2007....
- Vascularization is the key challenge in tissue engineeringEsther C Novosel
University of Stuttgart, Institute for Interfacial Engineering, Nobelstrasse 12, Stuttgart, Germany
Adv Drug Deliv Rev 63:300-11. 2011..Advantages and pitfalls of the approaches to create vascularized tissues in vitro are outlined and feasible future strategies are discussed...
- Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cellsJanne L Simonsen
Department of Endocrinology and Metabolism, University Hospital of Aarhus, DK 8000 Aarhus C, Denmark
Nat Biotechnol 20:592-6. 2002..These results suggest that ectopic expression of telomerase in hMSCs prevents senescence-associated impairment of osteoblast functions...
- Biomimetic nanofibrous scaffolds for bone tissue engineeringJeremy M Holzwarth
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
Biomaterials 32:9622-9. 2011Bone tissue engineering is a highly interdisciplinary field that seeks to tackle the most challenging bone-related clinical issues. The major components of bone tissue engineering are the scaffold, cells, and growth factors...
- Nanofibers and their applications in tissue engineeringRajesh Vasita
Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India
Int J Nanomedicine 1:15-30. 2006..that mimic the architecture of tissue at the nanoscale is one of the major challenges in the field of tissue engineering. The development of nanofibers has greatly enhanced the scope for fabricating scaffolds that can potentially ..
- Can tissue engineering concepts advance tumor biology research?Dietmar W Hutmacher
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia
Trends Biotechnol 28:125-33. 2010Advances in tissue engineering have traditionally led to the design of scaffold- or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix...
- Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineeringKarina H Nakayama
Center of Excellence in Translational Human Stem Cell Research, California National Primate Research Center, Davis, California 95616 8542, USA
Tissue Eng Part A 16:2207-16. 2010..Further, this study provides the initial steps in developing new regenerative medicine strategies for renal tissue engineering and repair.
- An alginate hydrogel matrix for the localised delivery of a fibroblast/keratinocyte co-cultureNicola C Hunt
University of Birmingham, UK
Biotechnol J 4:730-7. 2009..These findings demonstrate that alginate hydrogel may be an effective delivery vehicle and scaffold for the healing of full-thickness skin wounds...
- Electrospun nanofibrous structure: a novel scaffold for tissue engineeringWan Ju Li
School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA
J Biomed Mater Res 60:613-21. 2002..This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth.
- Chitosan scaffolds for osteochondral tissue regenerationAnder Abarrategi
Instituto de Estudios Biofuncionales, Universidad Complutense, Madrid, Spain
J Biomed Mater Res A 95:1132-41. 2010..49 KDa), and lowest deacetylation degree (83%) shows a well structured subchondral bone and noticeable cartilaginous tissue regeneration, being it the best one of those tested for osteochondral defect regeneration...
- Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffoldsStephen F Badylak
Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Annu Rev Biomed Eng 13:27-53. 2011..Critical challenges and future directions are also discussed...
- Growth factor-loaded scaffolds for bone engineeringJ A Jansen
Department of Periodontology and Biomaterials, University Medical Center, THK 117, P O Box 9101, 6500 HB Nijmegen, The Netherlands
J Control Release 101:127-36. 2005..Nevertheless, orthotopic bone formation in a rabbit cranial defect model was stimulated in rhTGF-beta1- and rhBMP-2-loaded CaP cement and Ti-fiber mesh scaffolds compared with non-loaded implants...
- Proangiogenic scaffolds as functional templates for cardiac tissue engineeringLauran R Madden
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 107:15211-6. 2010..This work establishes a foundation for spatially controlled cardiac tissue engineering by providing discrete compartments for cardiomyocytes and stroma in a scaffold that enhances vascularization ..
- The application of polyhydroxyalkanoates as tissue engineering materialsGuo Qiang Chen
Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
Biomaterials 26:6565-78. 2005..making them attractive as biomaterials for applications in both conventional medical devices and tissue engineering. Over the past years, PHA, particularly poly 3-hydroxybutyrate (PHB), copolymers of 3-hydroxybutyrate and 3-..
- In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for bone tissue engineeringBalaji Sitharaman
Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
Bone 43:362-70. 2008Scaffolds play a pivotal role in the tissue engineering paradigm by providing temporary structural support, guiding cells to grow, assisting the transport of essential nutrients and waste products, and facilitating the formation of ..
- Electrospun materials as potential platforms for bone tissue engineeringJun Hyeog Jang
Department of Biochemistry, Inha University College of Medicine, South Korea
Adv Drug Deliv Rev 61:1065-83. 2009..tools have been developed to mimic the native bone extracellular matrix for potential applications as tissue engineering scaffolds and ultimately to restore degenerated functions of the bone...
- Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfacesTatsuya Shimizu
Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, Japan
Circ Res 90:e40. 2002..Cardiac tissue engineering is currently pursued utilizing conventional technology to fabricate 3-D biodegradable scaffolds as a ..
- Toward delivery of multiple growth factors in tissue engineeringFa Ming Chen
Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an 710032, Shaanxi, People s Republic of China
Biomaterials 31:6279-308. 2010..a tissue either in vitro or in vivo has led to the integration of a wide variety of growth factors (GFs) in tissue engineering strategies in an effort to mimic the natural microenvironments of tissue formation and repair...
- Hydrogel-beta-TCP scaffolds and stem cells for tissue engineering boneChristian Weinand
Laboratory for Tissue Engineering and Organ Fabrication, Warren 11 1157, Massachusetts General Hospital, Harvard, Medical School, 55 Fruit Street, Boston, MA 02114, USA
Bone 38:555-63. 2006..To overcome these limitations, we used a tissue engineering approach to create bone replacements in vitro, combining bone-marrow-derived differentiated mesenchymal stem ..
- Implantable applications of chitin and chitosanEugene Khor
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Kent Ridge, Singapore 117543, Singapore
Biomaterials 24:2339-49. 2003..been shown to be useful as a wound dressing material, drug delivery vehicle and increasingly a candidate for tissue engineering. The promise for this biomaterial is vast and will continue to increase as the chemistry to extend its ..
- Cartilage tissue engineering: towards a biomaterial-assisted mesenchymal stem cell therapyClaire Vinatier
INSERM, U 791, LIOAD, Nantes, F 44042, France
Curr Stem Cell Res Ther 4:318-29. 2009..surgery, the lack of efficient modalities of treatment for large chondral defects has prompted research on tissue engineering combining chondrogenic cells, scaffold materials and environmental factors...
- Collagen scaffolds for tissue engineeringJulie Glowacki
Department of Orthopedic Surgery, Brigham and Women s Hospital, Boston, MA, USA
Biopolymers 89:338-44. 2008There are two major approaches to tissue engineering for regeneration of tissues and organs. One involves cell-free materials and/or factors and one involves delivering cells to contribute to the regeneraion process...
- Porous scaffold design for tissue engineeringScott J Hollister
Scaffold Tissue Engineering Group, Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 41809, USA
Nat Mater 4:518-24. 2005A paradigm shift is taking place in medicine from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous material scaffolds integrated with biological cells or molecules to regenerate ..
- Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cellsJuan M Melero-Martin
Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Circ Res 103:194-202. 2008The success of therapeutic vascularization and tissue engineering will rely on our ability to create vascular networks using human cells that can be obtained readily, can be expanded safely ex vivo, and can produce robust vasculogenic ..
- The development of a bioengineered organ germ methodKazuhisa Nakao
Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba, 278 8510, Japan
Nat Methods 4:227-30. 2007..Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies...
- Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: a comparison with human mesenchymal stem cells from adipose tissueSusanne Wolbank
Red Cross Blood Transfusion Service of Upper Austria, Linz, Austria
Tissue Eng 13:1173-83. 2007Bone marrow-derived mesenchymal stem cells (BMSCs) have been used for allogeneic application in tissue engineering but have certain drawbacks...
- Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivoYing Cao
Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
Biochem Biophys Res Commun 332:370-9. 2005..Because ADAS cells can be expanded in culture without obvious senescence for more than 20 population doublings, they may be a potential source of endothelial cells for cellular pro-angiogenic therapies...
- Biomimetic materials for tissue engineeringPeter X Ma
Department of Biologic and Materials Sciences, The University of Michigan, Ann Arbor, MI 48109 1078, USA
Adv Drug Deliv Rev 60:184-98. 2008b>Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation...
- Cartilage engineering: a crucial combination of cells, biomaterials and biofactorsClaire Vinatier
INSERM, U 791, LIOAD, Nantes, F 44042, France
Trends Biotechnol 27:307-14. 2009..The lack of efficient modalities of treatment has prompted research into tissue engineering combining chondrogenic cells, scaffold materials and environmental factors...
- Stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineeringGuorui Jin
Department of Mechanical Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore 117576, Singapore
Acta Biomater 7:3113-22. 2011..MSC have been the focus of many tissue engineering studies, mainly because of their multipotential properties...
- Growth factor delivery-based tissue engineering: general approaches and a review of recent developmentsKangwon Lee
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02139, USA
J R Soc Interface 8:153-70. 2011..This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively ..
- Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic developmentCatharine A Hellingman
Department of Otorhinolaryngology, University Medical Center Rotterdam, Rotterdam, The Netherlands
Tissue Eng Part A 16:545-56. 2010..These results will help us understand the role of FGF signaling in chondrogenesis and find new tools to monitor and control chondrogenic differentiation...
- Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodelingJason D Roh
Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 107:4669-74. 2010..These findings suggest TEVGs transform into functional neovessels via an inflammatory process of vascular remodeling...
- Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytesA Marsano
Departments of Surgery and Research, University Hospital Basel, Basel, Switzerland
Osteoarthritis Cartilage 15:48-58. 2007..To identify an appropriate cell source for the generation of meniscus substitutes, among those which would be available by arthroscopy of injured knee joints...
- Rapid prototyping in tissue engineering: challenges and potentialWai Yee Yeong
Rapid Prototyping Research Laboratory, Design Research Centre, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore 639798
Trends Biotechnol 22:643-52. 2004b>Tissue engineering aims to produce patient-specific biological substitutes in an attempt to circumvent the limitations of existing clinical treatments for damaged tissue or organs...
- Improved tissue-engineered bone regeneration by endothelial cell mediated vascularizationHaiying Yu
Department of Orthopaedic Surgery, Wayne State University, Detroit, MI 48201, USA
Biomaterials 30:508-17. 2009..These findings suggest that hybrid grafts have great potential for clinical use to treat large bone defects...
- Tissue engineering and the use of stem/progenitor cells for airway epithelium repairGodfried M Roomans
School of Health and Medical Sciences, Orebro University, Orebro University Hospital, SE 70185 Orebro, Sweden
Eur Cell Mater 19:284-99. 2010..Clinical applications so far are few, but include subglottic stenosis, tracheomalacia, bronchiomalacia, and emphysema...
- A cell-laden microfluidic hydrogelYibo Ling
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Lab Chip 7:756-62. 2007..cells within the bulk material of microfluidic channels may be beneficial for applications ranging from tissue engineering to cell-based diagnostic assays...
- Nanopattern-induced changes in morphology and motility of smooth muscle cellsEvelyn K F Yim
Department of Biomedical Engineering, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Biomaterials 26:5405-13. 2005..It is proposed that this nanoimprinting technology will provide a valuable platform for studies in cell-substrate interactions and for development of medical devices with nanoscale features...
- Advances in musculoskeletal tissue engineering: moving towards therapyCarlo Alberto Rossi
Surgery Unit, UCL Institute of Child Health and Great Ormond Street Hospital, London, United Kingdom
Organogenesis 6:167-72. 2010..In the last decade, tissue engineering looked at overcoming these problems by investigating alternative treatment options, i.e...
- Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterialsRonald E Unger
Institute of Pathology, REPAIR Lab, Johannes Gutenberg University, Mainz 55101, Germany
Biomaterials 28:3965-76. 2007..Our results underline the necessity to take into account the in situ production of growth factors by invading mesenchymal cells in the regenerative niche...
- Craniofacial tissue engineering by stem cellsJ J Mao
Columbia University College of Dental Medicine and Biomedical Engineering, 630 W 168 St PH7 CDM, New York, NY 10032, USA
J Dent Res 85:966-79. 2006Craniofacial tissue engineering promises the regeneration or de novo formation of dental, oral, and craniofacial structures lost to congenital anomalies, trauma, and diseases...
- Training in Biomolecular and Tissue EngineeringFarshid Guilak; Fiscal Year: 2007The Center for Biomolecular and Tissue Engineering (CBTE) at Duke University proposes a post-doctoral training program in the application of bioengineering principles to the design, manipulation, and quantitative characterization of ..
- BIOENGINEERING OF BLADDER TISSUESAnthony Atala; Fiscal Year: 2003..Specific Aim 2: To determine the feasibility of attaining complete bladder replacement using tissue engineering techniques...
- Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue RepairDavid Butler; Fiscal Year: 2007Abstract In the last two decades, tissue engineering in academia and industry has become an exciting, multidisciplinary field offering the potential to repair or regenerate injured and diseased musculoskeletal and craniofacial tissues ..
- A Biological Basis for Repair of the ACLChristopher Evans; Fiscal Year: 2009..MRI, histology and immunohistochemistry will also be used to evaluate the healed ligament. These studies will advance our knowledge of the biology of the injured ACL and suggest novel, biologically-based approaches to healing. ..
- Transfer of IL-1Ra cDNA to Osteoarthritic KneeChristopher Evans; Fiscal Year: 2008..abstract_text> ..
- Insulin Producing Cells from Amniotic Stem Cells for Diabetes TherapyAnthony Atala; Fiscal Year: 2009..Successful development of an abundant source of transplantable insulin producing cells potentially would have a profound impact on the treatment of a major public health problem. ..
- TISSUE ENGINEERING OF THE TEMPOROMANDICULAR JOINTAnthony Ratcliffe; Fiscal Year: 2003..The growth of tissues in vitro for in vivo transplantation and repair (tissue engineering) has recently been demonstrated to have immense potential...
- Chondrogenesis in Enzymatically Degradable HydrogelsJASON BURDICK; Fiscal Year: 2008..support to the principle investigator in the area of advancing photopolymerizable hydrogels for cartilage tissue engineering in addition to support (4 years) as an independent faculty member to continue research in this field...
- Cartilage-Cartilage Adhesion by PhotopolymerizationAnthony Ratcliffe; Fiscal Year: 2004..These in vitro studies will demonstrate whether this approach is feasible for testing in in vivo situations (Phase II application). ..
- 2008 Musculoskeletal Biology and Bioengineering Gordon Research ConferenceFarshid Guilak; Fiscal Year: 2008..The meeting will consist of 9 separate sessions, consisting of invited speakers and selected attendees at various levels of career development. [unreadable] [unreadable] [unreadable] [unreadable]..
- Development of a Multi-phased Scaffold for Soft Tissue to Bone IntegrationHelen Lu; Fiscal Year: 2006..abstract_text> ..
- Antimicrobial Gene TherapyGeorge Huang; Fiscal Year: 2003....
- "In Vitro Mechanical Stimulation to Enhance Tendon Repair"David Butler; Fiscal Year: 2009..Using a functional tissue engineering or FTE roadmap with linked in vitro and in vivo studies, we will establish in vivo forces and displacements ..
- CERAMIC WHISKER REINFORCEMENT OF DENTAL COMPOSITE RESINSHUAKUN XU; Fiscal Year: 2002....
- Human Tissue Engineered Matrix Constructs for RepairAnthony Ratcliffe; Fiscal Year: 2007..A functional tissue engineering approach is being used to develop a device that will enhance the surgical repair of rotator cuff tendons...
- CONTROLLED RELEASE OF MACROMOLECULESRobert Langer; Fiscal Year: 2007..Our best performing polymer-DNA formulations, identified in aims one and two, wilt be assayed in vivo in mice for 1) delivery efficiency, 2) specificity and biodistribution, and 3) complement activation and initial safety profile. ..
- Cell-specific Delivery of RNAi to Pulmonary Alveolar Macrophages in vivoDarrell Kotton; Fiscal Year: 2007..Finally, the system is applied for in vivo knockdown of NF-kB signaling in mouse alveolar macrophages and the treatment of tobacco smoke- induced lung inflammation. [unreadable] [unreadable] [unreadable]..
- MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet CellsJEFF BULTE; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Neuropeptide Y Regulation of Peripheral Human Nociceptors and PainKenneth Hargreaves; Fiscal Year: 2007..Moreover, our study population in South Texas permits secondary analyses of a potentially underserved population (predominantly Hispanic) that is at risk for caries-induced pulpal necrosis and pain. [unreadable] [unreadable]..
- Cardiac KATP Channels in Health and DiseaseAndre Terzic; Fiscal Year: 2007..Thus, this proposal will provide an integrated understanding of cardiac KATP channels in metabolic signal decoding, stress adaptation, and their impact for clinical medicine. ..
- Derivation of Lung Epithelium from Bone MarrowDarrell Kotton; Fiscal Year: 2007....
- Neuronal Biointerface: Micropatterned Lipid BilayersLance Kam; Fiscal Year: 2006..unreadable] [unreadable]..
- Bone Marrow Stromal Cells for Bladder Tissue EngineeringYuanyuan Zhang; Fiscal Year: 2006..3.3) Evaluate extent of bladder regeneration at different time points through histology, contractility assays, and immunohistochemical staining. [unreadable] [unreadable] [unreadable]..
- Mesoporus Diamondlike Carbon Medical Device MembraneRoger Narayan; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Automated Analysis of Learning and Memory for Neuro-Developmental StudiesMichael Levin; Fiscal Year: 2010..These three outcomes will result in the eventual development of novel therapeutics for brain diseases. ..
- Repair and regeneration in a novel animal modelCheng Ming Chuong; Fiscal Year: 2008unreadable] DESCRIPTION (provided by applicant): Regenerative medicine and tissue engineering have emerged as some of the most fascinating fields with potentially high clinical applications...
- Ultrasound Technologies for Tissue EngineeringDENISE C contact HOCKING; Fiscal Year: 2010..b>Tissue engineering is a potentially revolutionary approach for replacing or regenerating diseased or destroyed organs and ..
- Stem Cell Based Soft Tissue ReconstructionJeremy J Mao; Fiscal Year: 2010..of isolated meritorious attempts to engineer soft tissue by cell-based approaches, the effort level on soft tissue engineering lags far behind hard (bone) tissue engineering...
- Mechanical Feedback on Cell Structure and SignalingShu Chien; Fiscal Year: 2010..The results generated from these proposed studies will provide insight into the cellular adaptation mechanisms and homeostasis of biological functions in responses to stretch. ..
- HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLSJORDAN POBER; Fiscal Year: 2009..These data will provide a rational basis for developing new, complementary strategies to further reduce the incidence and consequences of allograft rejection. ..
- The Role of Phosphatases in EC MechanotransductionShu Chien; Fiscal Year: 2009....
- Prostaglandin Signaling in Wear Debris-induced OsteolysisREGIS O KEEFE; Fiscal Year: 2009....
- The CXCR4-SDF-1 Axis in Metastatic RhabdomyosarcomaMariusz Ratajczak; Fiscal Year: 2009..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
- BIOSENSOR BIOCOMPATIBILITYWilliam Reichert; Fiscal Year: 2008..abstract_text> ..
- AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESISDavid Warburton; Fiscal Year: 2009..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
- Developing a CEST Reporter Gene (RMI)JEFF BULTE; Fiscal Year: 2008..To achieve this goal, our aim is to synthesize novel, more efficient CEST reporter genes, and to detect double-labeled LRP/ARP transfected glioma cells and neural stem cells individually in live animals. [unreadable] [unreadable]..
- Biomimetic Nanofibrillar Scaffolds For Cartilage Tissue EngineeringAnu Subramanian; Fiscal Year: 2008..The regenerative capabilities of articular cartilage are very limited when injured or damaged by aging, tissue engineering concepts and methodologies that employ biocompatible matrices or scaffolds have the potential to help repair ..
- Microfluidics systems for formulation of contrast agents for molecular imagingAbraham Lee; Fiscal Year: 2008..The further development of this microfluidic system, and resulting production of monodisperse contrast agents, will open several new avenues for high sensitivity targeted ultrasound imaging. [unreadable] [unreadable] [unreadable]..
- HEPATIC TISSUE ENGINEERINGMartin Yarmush; Fiscal Year: 2006..The proposed studies will also provide basic tools useful in the development of other engineered tissues and organs. ..
- Cartilage-Cartilage Adhesion by PhotopolymerizationAnthony Ratcliffe; Fiscal Year: 2006..The successful outcome of this project will allow for submission to the FDA for product clearance (510k) or initiation of a clinical trial. ..
- Molecular Mechanism of Endothelial Migration Under FlowShu Chien; Fiscal Year: 2004..abstract_text> ..
- LONG TERM NERVE REGENERATION THROUGH COLLAGEN DEVICESIoannis Yannas; Fiscal Year: 2001..These data will be useful for all investigators studying the efficacy of devices for peripheral nerve regeneration. ..
- MR-Guided Delivery and Monitoring of Magnetocapsules Immunoprotecting Islet CellsJEFF BULTE; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- HEPARAN SULFATE IN CELLULAR IMMUNITY AND GRAFT REJECTIONJeffrey Platt; Fiscal Year: 2003..These studies will use allo- and xenotransplant models. ..
- 5th Bone Fluid Flow WorkshopMELISSA KNOTHE TATE; Fiscal Year: 2003..Furthermore, implications of fluid flow for tissue engineering (Session 5) and patient care (Session 6) will be addressed...
- The Osteoblastic Monolayer as a 'Gatekeeper' in BoneMELISSA KNOTHE TATE; Fiscal Year: 2003..This study is expected to provide insight into new strategies for treatment of bone diseases such as osteoporosis and osteoarthritis. ..
- Enhancing in vitro Cartilge Synthesis for Human TherapyAnthony Ratcliffe; Fiscal Year: 2004..PROPOSED COMMERCIAL APPLICATION: Tissue engineering of cartilage in vitro, followed by transplantation for human therapy of articular surface defects.
- PATHOGENIC MECHANISMS OF VENOUS DISEASEVincent Falanga; Fiscal Year: 2004..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
- Cardiac Pacemaking and Conduction System SymposiumROBERT GOURDIE; Fiscal Year: 2004..A website on the "cardiac pacemaking and conduction system" will be established at Medical University of South Carolina with content arising from work presented and published from the meeting. ..
- Patterning by Invasive Mesenchyme in the Embryonic HeartROBERT GOURDIE; Fiscal Year: 2005..abstract_text> ..
- CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPENMariusz Ratajczak; Fiscal Year: 2002..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
- Functional Tissue Engineering of Articular CondyleJeremy Mao; Fiscal Year: 2006..The anticipated findings may have implications in the ultimate ex vivo fabrication of tissue-engineered articular condyles using cell-based regenerative approaches. ..
- CELL CYCLE OF CORNEAL ENDOTHELIUMNancy Joyce; Fiscal Year: 2005..Immunoprecipitation, Western blotting, RT-PCR, immunocytochemistry, flow cytometry, antisense methods, and expression of dominant-negative mutants will be used to accomplish the objectives of this proposal. ..
- MOLECULAR BASIS OF TOXICANT INDUCED VERTEBRAL ANOMALIESRocky Tuan; Fiscal Year: 2001....
- TMJ Bioengineering ConferenceMICHAEL DETAMORE; Fiscal Year: 2006..A benchmark for contemporary knowledge of the TMJ will be assessed by 38 speakers in sessions on tissue engineering, biomechanics, biology and clinical treatment...
- GROWTH FACTORS AND EPIPHYSEAL CHONDROCYTE MATURATIONREGIS O KEEFE; Fiscal Year: 2006..unreadable] [unreadable]..
- PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATIONKenneth Hargreaves; Fiscal Year: 2002..This knowledge base may provide a rationale for developing peripherally-selective cannabinoid analgesics with minimal CNS-mediated side-effect liability. ..
- Novel Mechanism of Induction of Eye Tissue: Katp Channel ModulationMichael Levin; Fiscal Year: 2010....
- A Novel Engineered Composite Construct for Articular Cartilage RepairAnthony Ratcliffe; Fiscal Year: 2008..The results obtained will provide the data necessary for a regulatory submission to the FDA to market the product. [unreadable] [unreadable] [unreadable] [unreadable]..
- Mechanisms of Marrow-Derived Stem Cell Remodeling of Aged Emphysematous LungsDaniel Weiss; Fiscal Year: 2008..abstract_text> ..
- LONG TERM NERVE REGENERATION THROUGH COLLAGEN DEVICESIoannis Yannas; Fiscal Year: 2002..These data will be useful for all investigators studying the efficacy of devices for peripheral nerve regeneration. ..
- Mechanical and Molecular Bases of Endothelial RemodelingShu Chien; Fiscal Year: 2009..abstract_text> ..
- Cannabinoid Modulation of Capsaicin-Sensitive NociceptorsKenneth M Hargreaves; Fiscal Year: 2010..Second, identification of cannabinoid modulation of pain via TRPchannels provides a rationale for a novel class of analgesics that are devoid of classical cannabinoid side effects. ..
- MICROCHIP DRUG DELIVERY SYSTEMRobert Langer; Fiscal Year: 2003..abstract_text> ..
- Development of the Mouse Cochlea DatabasePETER ALAN SANTI; Fiscal Year: 2010..abstract_text> ..
- FIBRONECTIN DEPOSITION AND PULMONARY FIBROSISDENISE HOCKING; Fiscal Year: 2002....
- In Vitro Synthesis of Fibrosis GenesisCELESTE NELSON; Fiscal Year: 2008..We present here a three-dimensional, microlithography-based model that can be used to break down the key steps involved in the earliest stages of fibrosis genesis. [unreadable] [unreadable] [unreadable]..
- Lung epithelial and vascular morphogenesisDavid Warburton; Fiscal Year: 2006..abstract_text> ..
- Restoration of Skin Structure and Function Post-WoundingROBERT GOURDIE; Fiscal Year: 2006..It is FSR's overall objective to develop its peptide into a pharmaceutically acceptable topical agent for application to surgical and non-surgical skin wounds in humans. [unreadable] [unreadable] [unreadable]..
- The Role of Ductin in Embryonic MorphogenesisMichael Levin; Fiscal Year: 2007..unreadable] [unreadable]..
- Stem-Cell Based Tissue Engineering in Regenerative Medicine ConferenceJeremy Mao; Fiscal Year: 2006..provided by applicant): This is a conference grant application (R13) requesting funding for Stem Cell-Based Tissue Engineering in Regenerative Medicine Conference as the central theme of the 24th Society for Physical Regulation in ..
- Robotic Simulation: Tissue Function with In Vivo MotionsDavid Butler; Fiscal Year: 2007..These technologies will serve as a platform for studying injury, repair and reconstruction in the knee and other joints and to develop functional tissue engineering parameters. [unreadable] [unreadable] [unreadable]
- Neuroprotection with serpins during cardiac surgeryRichard A Jonas; Fiscal Year: 2010..The final phase will study mechanisms of vascular protection afforded by aprotinin. The proposed study has the potential to reduce the risk of brain injury in children and adults undergoing heart surgery. ..
- 3D Woven Scaffolds for Tissue EngineeringFarshid Guilak; Fiscal Year: 2003b>Tissue engineering is a relatively new but rapidly growing field that has sought to use combinations of implanted cells, biomaterials, and biologically active molecules to repair or regenerate injured or diseased tissues...
- Cell phenotype-controlled mechanical signaling of MSCsDavid Butler; Fiscal Year: 2004Functional tissue engineering (FTE) seeks to enhance tissue engineered (TE) repairs using in vivo loads and strains from normal tissues to condition the constructs to their mechanical environment prior to surgery...
- The influence of ischemic microenvironment and stem cell differentiationRandall Lee; Fiscal Year: 2008..unreadable] Specific aim 2: To test the hypothesis that the microenvironment influences SC differentiation, angiogenesis and LV remodeling. [unreadable] [unreadable] [unreadable]..
- Dental Implant Science & Tech Transfer Satellite MeetingJack Lemons; Fiscal Year: 2004..Both organizations, IRG and WCOI-6 have approved the collaborations. Experience has been that 400 or more implant dentists attend the WCOI-6 and i00 or more researchers attend the IRG satellite sessions. ..
- Novel Cellular Lifespan Extension for Tissue EngineeringLaura Niklason; Fiscal Year: 2006unreadable] DESCRIPTION (provided by applicant): Vascular tissue engineering is a rapidly accelerating area...
- Epidemiology of Connective Tissue Progenitor PopulationsGeorge Muschler; Fiscal Year: 2006..CTPs are also central to efforts in Orthopaedic Tissue Engineering, both as tools for cell therapy and as targets for local and systemic therapy...
- Regulation of osteoblast function by endothelin-1Gregory Clines; Fiscal Year: 2006..Since sex steroids modulate the effects of ETA blockade, eugonadal and castrated mice will be analyzed for gross anatomic and histologic bone developmental abnormalities. [unreadable] [unreadable]..
- OPTIMIZING BONE MARROW AS A BONE GRAFTGeorge Muschler; Fiscal Year: 2005The Broad Aim of this proposal is to advance the field of Bone Tissue Engineering by defining general principles and techniques that can be applied to the rapid harvest and intra- operative transplantation of bone marrow derived ..
- Optimizing Assays of Human Stem Cells in Bone MarrowGeorge Muschler; Fiscal Year: 2007..abstract_text> ..
- CARDIAC GRAFTS--SKELETAL MYOBLASTSCHARLES MURRY; Fiscal Year: 2005....
- TISSUE ENGINEERING OF BLOOD VESSEL SUBSTITUTESJoseph Vacanti; Fiscal Year: 2002..While the preliminary studies have been encouraging, information concerning the cell biology of tissue engineered conduits is scant. ..
- Arteries Engineered from Porcine Vascular CellsLaura Niklason; Fiscal Year: 2005..The tissue engineering of autologous vessels for these patients could have an enormous impact on therapy for cardiovascular disease...
- Polymer/Ceramic Composites for Tissue EngineeringCato Laurencin; Fiscal Year: 2009b>Tissue engineering has developed into a truly interdisciplinary field offering promises to revitalize or replace damaged or lost human tissue/organs...
- SPINAL BENDING MOTIONS FOR PREVENTING DISC DEGENERATIONAdam Hsieh; Fiscal Year: 2003..These regimens will then be tested experimentally to determine the effects on biosynthesis and apoptosis. ..
- Intermediate filament control of neuronal mechanicsSanjay Kumar; Fiscal Year: 2005..abstract_text> ..
- Effects of Microengineered Interactions on Liver-Specific Gene ExpressionAlexander Revzin; Fiscal Year: 2007..In the future, proposed microfabricated devices will be used to induce differentiation of human ESC toward hepatic lineage. [unreadable] [unreadable] [unreadable]..
- Novel Biodegradable Polymers for Tissue EngineeringCato Laurencin; Fiscal Year: 2004..Thus, the objective of this project is to use a tissue engineering approach to develop new materials as practical alternatives to current bone repair materials...