Genomes and Genes
clinical laboratory techniques
Summary: Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.
Publications315 found, 100 shown here
- Errors in clinical laboratories or errors in laboratory medicine?Mario Plebani
Department of Laboratory Medicine, University Hospital of Padova and Center of Biomedical Research, Castelfranco Veneto, Italy
Clin Chem Lab Med 44:750-9. 2006..In a modern approach to total quality, centered on patients' needs and satisfaction, the risk of errors and mistakes in pre- and post-examination steps must be minimized to guarantee the total quality of laboratory services...
- Accuracy of urine circulating cathodic antigen (CCA) test for Schistosoma mansoni diagnosis in different settings of Côte d'IvoireJean T Coulibaly
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
PLoS Negl Trop Dis 5:e1384. 2011..We assessed the accuracy of a commercially available CCA cassette test (designated CCA-A) and an experimental formulation (CCA-B) for S. mansoni diagnosis...
- Low quality of routine microscopy for malaria at different levels of the health system in Dar es SalaamJudith Kahama-Maro
City Medical Office of Health, Dar es Salaam City Council, P O Box 63320, Dar es Salaam, United Republic of Tanzania
Malar J 10:332. 2011....
- Strongyloides stercoralis: there but not seenMartin Montes
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
Curr Opin Infect Dis 23:500-4. 2010..This review will highlight current published research on improved diagnostic methods for S. stercoralis and the immune mechanisms thought to be responsible for hyperinfection syndrome...
- Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference valuesAlexander Kratz
Department of Pathology Clinical Hematology Laboratory, Massachusetts General Hospital, USA
N Engl J Med 351:1548-63. 2004
- Comparison of CareStart™ HRP2/pLDH COMBO rapid malaria test with light microscopy in north-west EthiopiaBeyene Moges
Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, 196, Gondar, Ethiopia
Malar J 11:234. 2012..This study was aimed at testing the diagnostic performance of CareStart™ malaria rapid diagnostic test (RDT) with reference to light microscopy for the diagnosis of falciparum and vivax malaria in Ethiopia...
- A research agenda for helminth diseases of humans: diagnostics for control and elimination programmesJames S McCarthy
Queensland Institute of Medical Research, University of Queensland, Herston, Australia
PLoS Negl Trop Dis 6:e1601. 2012..In this review, the diagnostic technologies relevant to control of helminth infections, either available or in development, are reviewed. Critical gaps are identified and opportunities to improve needed technologies are discussed...
- Real-time PCR in the microbiology laboratoryI M Mackay
Clinical Virology Research Unit, Sir Albert Sakzewski Virus Research Centre and Department of Paediatrics, Royal Children s Hospital, Brisbane, Queensland, Australia
Clin Microbiol Infect 10:190-212. 2004..Additionally, the advantages, limitations and general background of real-time PCR technology will be reviewed in the context of the microbiology laboratory...
- Errors in laboratory medicinePierangelo Bonini
Universita Vita Salute San Raffaele, Cattedra di Biochimica Clinica, Via Olgettina 58, 20132 Milan, Italy
Clin Chem 48:691-8. 2002..The problem of medical errors has recently received a great deal of attention, which will probably increase. In this minireview, we focus on this issue in the fields of laboratory medicine and blood transfusion...
- Factors contributing to inappropriate ordering of tests in an academic medical department and the effect of an educational feedback strategySpiros Miyakis
Third Department of Internal Medicine, University of Athens, Sotiria General Hospital, Athens, Greece
Postgrad Med J 82:823-9. 2006..To identify factors contributing to laboratory overutilisation in an academic medical department, and to assess the effect of an educational feedback strategy on inappropriate test-ordering behaviour...
- Preanalytic error tracking in a laboratory medicine department: results of a 1-year experienceGiuseppe Lippi
Clin Chem 52:1442-3. 2006
- Malaria rapid diagnostic tests in elimination settings--can they find the last parasite?M L McMorrow
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Microbiol Infect 17:1624-31. 2011....
- Impact of blood collection devices on clinical chemistry assaysRaffick A R Bowen
Department of Pathology, Stanford University, 300 Pasteur Drive, Room H1507 B, Stanford, CA 94305, USA
Clin Biochem 43:4-25. 2010..This review will identify sources of exogenous substances in blood specimens and propose methods to minimize their impact on clinical chemistry assays...
- Errors in medicineLucian L Leape
Harvard School of Public Health, Boston, MA 02115, United States
Clin Chim Acta 404:2-5. 2009..We move our models of care from reliance on independent, individual performance excellence to interdependent, collaborative, interprofessional teamwork; 6. Accountability is universal and reciprocal, not top-down...
- Evaluation of six commercial point-of-care tests for diagnosis of acute dengue infections: the need for combining NS1 antigen and IgM/IgG antibody detection to achieve acceptable levels of accuracyStuart D Blacksell
Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Clin Vaccine Immunol 18:2095-101. 2011..This study provides strong evidence of the value of combining dengue antigen- and antibody-based test results in the rapid diagnostic test (RDT) format for the acute diagnosis of dengue...
- Quality Indicators in Laboratory Medicine: from theory to practice. Preliminary data from the IFCC Working Group Project "Laboratory Errors and Patient Safety"Laura Sciacovelli
Department of Laboratory Medicine and Center of Biomedical Research, University Hospital of Padova, Padova, Italy
Clin Chem Lab Med 49:835-44. 2011....
- Novel nested direct PCR technique for malaria diagnosis using filter paper samplesHans Peter Fuehrer
Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Kinderspitalgasse 15, A 1090 Vienna, Austria
J Clin Microbiol 49:1628-30. 2011..Direct PCR provides a rapid, highly sensitive, and cost-effective alternative to diagnosing malaria using filter paper samples and standard nested PCR...
- Causes, consequences, detection, and prevention of identification errors in laboratory diagnosticsGiuseppe Lippi
University of Verona, Verona, Italy
Clin Chem Lab Med 47:143-53. 2009..Once misidentification is detected, rejection and recollection is the most suitable approach to manage the specimen...
- Newer diagnostic approaches to intestinal protozoaLisette van Lieshout
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Curr Opin Infect Dis 23:488-93. 2010..To update the reader on the latest developments in the laboratory diagnosis of intestinal protozoa...
- Typhoid fever in sub-Saharan Africa: challenges of diagnosis and management of infectionsSamuel Kariuki
Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya
J Infect Dev Ctries 2:443-7. 2008....
- Urine heme dipsticks are useful in monitoring the impact of praziquantel treatment on Schistosoma haematobium in sentinel communities of Delta State, NigeriaEmmanuel Emukah
The Carter Center, Owerri, Imo State, Nigeria
Acta Trop 122:126-31. 2012..5% (p<0.001), and history and NVD identified only one of two villages still needing treatment. The study suggests that dipsticks should be the recommended method for launching and monitoring mass treatment for S. haematobium...
- Evaluation of eight serological tests for diagnosis of imported schistosomiasisHans Friedemann Kinkel
Institute of Tropical Medicine and International Health, Charite University Medicine Berlin, Berlin, Germany
Clin Vaccine Immunol 19:948-53. 2012..Serological tests are useful instruments for diagnosing imported schistosomiasis in countries where the disease is not endemic, but due to limitations in test sensitivities, we recommend the use of two or more assays in parallel...
- Laboratory demonstration of a prozone-like effect in HRP2-detecting malaria rapid diagnostic tests: implications for clinical managementJennifer Luchavez
Department of Parasitology, Research Institute for Tropical Medicine, Alabang, Muntinlupa City, The Philippines
Malar J 10:286. 2011..Aberrant results, whereby negative test results occur at high parasite densities, have been variously reported for over a decade and have led to questions regarding the reliability of the tests in clinical use...
- Increased and expedited case detection by Xpert MTB/RIF assay in childhood tuberculosis: a prospective cohort studyAndrea Rachow
Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich LMU, Munich, Germany
Clin Infect Dis 54:1388-96. 2012..The aim of this study was to evaluate the diagnostic performance of the Xpert MTB/RIF assay (Xpert) in children with suspected tuberculosis in a high tuberculosis/HIV-burden setting...
- Novel point-of-care test for simultaneous detection of nontreponemal and treponemal antibodies in patients with syphilisArnold R Castro
Laboratory Reference and Research Branch, Division of STD Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, MS A 12, Atlanta, GA 30333, USA
J Clin Microbiol 48:4615-9. 2010....
- Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic testsSören L Becker
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
BMC Infect Dis 13:37. 2013..We provide an overview of pathogens causing digestive disorders in the tropics and evaluate available reference tests...
- Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt-Jakob diseaseMichael D Geschwind
Department of Neurology, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
Arch Neurol 60:813-6. 2003..Previous studies have suggested that, in the proper clinical context, the 14-3-3 protein in cerebrospinal fluid is a reliable marker for sporadic CJD...
- Testing process errors and their harms and consequences reported from family medicine practices: a study of the American Academy of Family Physicians National Research NetworkJ Hickner
Department of Family Medicine, The University of Chicago Pritzker School of Medicine, 5841 S Maryland Ave, MC 7110, Suite M 156, Chicago, IL 60637 1470, USA
Qual Saf Health Care 17:194-200. 2008..Little is known about the types and outcomes of testing process errors that occur in primary care...
- Comparison of the Flotac-400 dual technique and the formalin-ether concentration technique for diagnosis of human intestinal protozoon infectionSören L Becker
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
J Clin Microbiol 49:2183-90. 2011....
- Real-time PCR in clinical microbiology: applications for routine laboratory testingM J Espy
Mayo Clinic, 200 First St SW, Hilton 470, Rochester, MN 55905, USA
Clin Microbiol Rev 19:165-256. 2006..This review focuses on the application of real-time PCR in the clinical microbiology laboratory...
- Health laboratories in the Tanga region of Tanzania: the quality of diagnostic services for malaria and other communicable diseasesD R S Ishengoma
National Institute for Medical Research, Tanga Centre, Tanga, Tanzania
Ann Trop Med Parasitol 103:441-53. 2009....
- Cost-effectiveness of routine rapid human immunodeficiency virus antibody testing before DNA-PCR testing for early diagnosis of infants in resource-limited settingsNicolas A Menzies
Centers for Disease Control and Prevention CDC, Global AIDS Program, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, CDC, Atlanta, GA, USA
Pediatr Infect Dis J 28:819-25. 2009....
- Detecting 2009 pandemic influenza A (H1N1) virus infection: availability of diagnostic testing led to rapid pandemic responseD B Jernigan
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Infect Dis 52:S36-43. 2011..Future planning efforts should identify ways to improve availability of reliable testing to manage patient care and approaches for optimal use of molecular testing for detecting and controlling emerging influenza virus strains...
- Improving the accuracy of malaria-related laboratory tests in GhanaImelda Bates
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Malar J 3:38. 2004..This study described the process and assessed the feasibility of establishing a nation-wide system for improving the accuracy of malaria-related tests in peripheral laboratories in Ghana...
- Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanksPatrizia Bernini
Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
J Biomol NMR 49:231-43. 2011..Appropriate procedures for blood derivatives collection and urine preservation/storage that allow maintaining as much as possible the original metabolic profile of the fresh samples emerge, and are proposed as SOPs for biobanking...
- Quality indicators and specifications for key analytical-extranalytical processes in the clinical laboratory. Five years' experience using the Six Sigma conceptMa Antònia Llopis
Laboratori Clínic Barcelonès Nord i Vallès Oriental ICS Metropolitana Nord, Badalona, Spain
Clin Chem Lab Med 49:463-70. 2011..Our purpose was to analyze the evolution of the indicators, identify processes that require corrective measures, and obtain specifications that are more robust than the preliminary ones proposed in a previous study by the same group...
- Diagnostic performance of CareStart™ malaria HRP2/pLDH (Pf/pan) combo test versus standard microscopy on falciparum and vivax malaria between China-Myanmar endemic bordersSun Xiaodong
National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention, WHO Collaborating Center on Malaria, Schisostomiasis and Filariasis, Shanghai, 200025, China
Malar J 12:6. 2013..Blood examination by microscopy was taken as gold standard to evaluate CareStart™ kit's sensitivity, specificity and predictive value and corrected with PCR assay...
- Preanalytical quality control program - an overview of results (2001-2005 summary)Ma Jesus Alsina
SEQC Committee for the Quality of the Extraanalytical Phase, Spain
Clin Chem Lab Med 46:849-54. 2008..Preanalytical variables, such as sample collection, handling, transport, and storage, may affect patient results. The number of errors in the preanalytical phase may decrease by following standardized procedures...
- Laboratory quality control based on risk managementJames H Nichols
Tufts University School of Medicine, Springfield, MA 01199, USA
Ann Saudi Med 31:223-8. 2011..Risk management principles will be reviewed and progress towards adopting a new Clinical and Laboratory Standards Institute Guideline for developing laboratory quality control plans based on risk management will be discussed...
- Incomplete filling of lithium heparin tubes affects the activity of creatine kinase and gamma-glutamyltransferaseG Lippi
U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Italy
Br J Biomed Sci 69:67-70. 2012..3% and 16.6% for the half-draw and low-draw tubes, respectively. These results suggest that short-draw lithium heparin tubes might be unsuitable for testing GGT and CK using specific combinations of reagents and instrumentation...
- Patient safety in the clinical laboratory: a longitudinal analysis of specimen identification errorsElizabeth A Wagar
University of California, Los Angeles, Clinical Laboratories, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Box 951732, AL 206 CHS 10833 Le Conte Ave, Los Angeles, CA 90095 1732, USA
Arch Pathol Lab Med 130:1662-8. 2006....
- Validation of a low-cost human papillomavirus genotyping assay based on PGMY PCR and reverse blotting hybridization with reusable membranesC Estrade
WHO HPV LabNet Regional Reference Laboratory for Europe, Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, and University of Lausanne, 1011 Lausanne, Switzerland
J Clin Microbiol 49:3474-81. 2011..40 per sample using the least expensive yet proficient genotyping algorithm that also included quality control. This assay may be used in low-resource laboratories that have sufficient manpower and PCR expertise...
- Laboratory use in Ghana: physician perception and practiceChristopher R Polage
Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA
Am J Trop Med Hyg 75:526-31. 2006..Physician perception regarding the value of diagnostic testing is potentially a major barrier to laboratory use, resulting in empiricism, disproportionate anti-microbial administration, and cost to patients...
- Managing the pre- and post-analytical phases of the total testing processRobert Hawkins
Department of Laboratory Medicine, Tan Tock Seng Hospital, Tan Tok Seng, Singapore
Ann Lab Med 32:5-16. 2012....
- Time to move from presumptive malaria treatment to laboratory-confirmed diagnosis and treatment in African children with feverValérie D'Acremont
Swiss Tropical Institute, Basel, Switzerland
PLoS Med 6:e252. 2009....
- Preanalytical delay reduces sensitivity of QuantiFERON-TB gold in-tube assay for detection of latent tuberculosis infectionDavid Doberne
3375 Hillview Avenue, Room 1602, Palo Alto, CA 94304, USA
J Clin Microbiol 49:3061-4. 2011..Compared to immediate incubation, 6- and 12-hour delays resulted in positive-to-negative reversion rates of 19% (5/26) and 22% (5/23), respectively. These findings underscore the need for standardizing QFT-GIT preanalytical practices...
- How can we make laboratory testing safer?D Joe Boone
Division of Laboratory Systems, National Center for Preparedness, Detection, and Control of Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Chem Lab Med 45:708-11. 2007....
- Quality improvement of mitochondrial respiratory chain complex enzyme assays using Caenorhabditis elegansXiulian Chen
Center for Developmental Therapeutics, Seattle Children s Research Institute, Seattle, Washington, USA
Genet Med 13:794-9. 2011..In this study, we explored the use of Caenorhabditis elegans mitochondria as a potential aid to diagnostic centers that perform respiratory chain complex assays...
- Towards harmonization of quality indicators in laboratory medicineMario Plebani
Department of Laboratory Medicine, Padua University Hospital, Padua, Italy
Clin Chem Lab Med 51:187-95. 2013..The identification of valuable QIs is a key step in paving the way towards quality and patient safety in laboratory medicine...
- An early report from newly established laboratory-based influenza surveillance in Lao PDRPhengta Vongphrachanh
National Center for Laboratory and Epidemiology, Bangkok, Thailand
Influenza Other Respir Viruses 4:47-52. 2010..Prior to 2007, little information was available about the burden of influenza in Laos. We report data from the first laboratory-based influenza surveillance system established in the Lao People's Democratic Republic...
- Epidemiology of chlamydial infection: are we losing ground?M L Rekart
STD AIDS Control, British Columbia Centre for Disease Control, 655 West 12th Ave, British Columbia, Vancouver, V5Z 4R4, Canada
Sex Transm Infect 84:87-91. 2008....
- Errors in laboratory medicine: practical lessons to improve patient safetyPeter J Howanitz
Department of Pathology, State University of New York Downstate, Brooklyn, NY 11203, USA
Arch Pathol Lab Med 129:1252-61. 2005..These databases include the CAP's Q-Probes and Q-Tracks programs, which provide information on error rates from more than 130 interlaboratory studies...
- The laboratory and patient safetyElizabeth A Wagar
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Road, Los Angeles, CA 90095, USA
Clin Lab Med 27:909-30, viii-ix. 2007..Emerging ideas on identifying and reducing laboratory errors, as well as specific strategies are reviewed and discussed with examples...
- Risk management in the preanalytical phase of laboratory testingGiuseppe Lippi
Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
Clin Chem Lab Med 45:720-7. 2007....
- The clinical plasma proteome: a survey of clinical assays for proteins in plasma and serumN Leigh Anderson
Plasma Proteome Institute, Washington, DC 20009 3450, USA
Clin Chem 56:177-85. 2010..This rate falls far short of that needed to support projected medical needs and indicates serious deficiencies in the protein biomarker pipeline, from which no proteomics-discovered analytes have yet emerged...
- A novel real-time PCR assay for the detection of Plasmodium falciparum and Plasmodium vivax malaria in low parasitized individualsSeung Young Hwang
Department of Parasitology, Inje University College of Medicine, Busan 614 735, South Korea
Acta Trop 120:40-5. 2011..The sensitivity threshold was 0.2 parasites/μl and no PCR-positive reaction occurred when malaria parasites were not present. This may be a useful method for detecting malaria parasites in endemic areas...
- Malaria rapid diagnostic testsMichael L Wilson
Department of Pathology and Laboratory Services, Denver Health, Denver, CO 80204 4507, USA
Clin Infect Dis 54:1637-41. 2012..The emphasis will be on the performance and use of MRDTs in regions of endemicity, particularly sub-Saharan Africa, where most malaria-related deaths occur...
- HIV diagnostic testing: evolving technology and testing strategiesDemetre Daskalakis
New York University Medical Center, New York, NY, USA
Top Antivir Med 19:18-22. 2011..This article summarizes a lecture by Demetre Daskalakis, MD, at the New York City IAS-USA continuing medical education program held in November 2009 and re-presented in December 2010...
- National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancersCatharine M Sturgeon
Department of Clinical Biochemistry, Royal Infirmary of Edinburgh, Edinburgh, UK
Clin Chem 54:e11-79. 2008..Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been developed...
- The era of molecular and other non-culture-based methods in diagnosis of sepsisNicasio Mancini
Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Diagnostica e Ricerca San Raffaele, Milano, Italia
Clin Microbiol Rev 23:235-51. 2010..In particular, the potential clinical role for the sensitive and rapid detection of bacterial and fungal DNA in the development of new diagnostic algorithms is discussed...
- Evaluation of rapid diagnostic tests for malaria case management in GabonDenise Patricia Mawili-Mboumba
Department of Parasitology Mycology and Tropical Medicine, Universite des Sciences de la Sante, Libreville, Gabon
Diagn Microbiol Infect Dis 66:162-8. 2010..These tests should be considered as a good alternative to microscopy, allowing not only an efficient and rapid diagnosis of malaria in primary health facilities but also to aid in promoting changes for antimalarial prescription behavior...
- CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern AfricaEtienne Karita
Projet San Francisco PSF, Kigali, Rwanda
PLoS ONE 4:e4401. 2009..The objective of this study was to establish clinical laboratory reference intervals for 25 hematology, immunology and biochemistry values among healthy African adults typical of those who might join a clinical trial...
- Exploring the iceberg of errors in laboratory medicineMario Plebani
Department of Laboratory Medicine, University Hospital of Padova, Italy
Clin Chim Acta 404:16-23. 2009..The lesson we have learned is that each practice must examine its own total testing process to discover its weaknesses and identify appropriate remedies...
- New diagnostic tests for tuberculosis: bench, bedside, and beyondSusan E Dorman
Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland 21212, USA
Clin Infect Dis 50:S173-7. 2010..Several promising new tools are at advanced stages of development and evaluation. This review describes some of those promising new technologies and the key barriers to their effective implementation...
- The World Health Organization African region laboratory accreditation process: improving the quality of laboratory systems in the African regionGuy Michel Gershy-Damet
Regional Program on AIDS, Inter Country Support Team West Africa, World Health Organization Regional Office for Africa, Ouagadougou 03, Burkina Faso
Am J Clin Pathol 134:393-400. 2010..We believe that the WHO-AFRO approach for laboratory accreditation is affordable, sustainable, effective, and scalable...
- Aspergillus PCR: one step closer to standardizationP Lewis White
NPHS Microbiology Cardiff, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, United Kingdom
J Clin Microbiol 48:1231-40. 2010..DNA should be eluted in volumes of <100 microl...
- Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory testsD R Dufour
Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC 20422, USA
Clin Chem 46:2027-49. 2000..To review information on performance characteristics for tests that are commonly used to identify acute and chronic hepatic injury...
- Do we know what inappropriate laboratory utilization is? A systematic review of laboratory clinical auditsC van Walraven
Institute for Clinical Evaluative Sciences, North York, Ontario, Canada
JAMA 280:550-8. 1998..Laboratory utilization has steadily increased, and some studies suggest inappropriate utilization. Therefore, we wished to assess studies that measure inappropriate laboratory use in light of methodological criteria...
- Quality assessment of malaria laboratory diagnosis in South AfricaLeigh Dini
Parasitology Reference Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Box 1038, Johannesburg 2000, South Africa
Trans R Soc Trop Med Hyg 97:675-7. 2003..The results clearly suggest that malaria laboratory diagnosis throughout South Africa needs strengthening by improving laboratory standardization and auditing, training, quality assurance and referral resources...
- Evaluation of envelope domain III-based single chimeric tetravalent antigen and monovalent antigen mixtures for the detection of anti-dengue antibodies in human seraGaurav Batra
International Centre for Genetic Engineering and Biotechnology, New Delhi, India
BMC Infect Dis 11:64. 2011....
- Saliva: reflection of the bodyDaniela Pereira Lima
Department of Pediatric and Preventive Dentistry, Araçatuba School of Dentistry, UNESP Sao Paulo State University, Rua José Bonifácio 1193, Aracatuba, SP, Brazil, 16015 050
Int J Infect Dis 14:e184-8. 2010..The value of these methods for the diagnosis of oral and systemic diseases has been the subject of study by several researchers with the aim of increasing its use alongside complementary exams...
- The IFCC Working Group on laboratory errors and patient safetyLaura Sciacovelli
Center of Biomedical Research, Castelfranco Veneto TV, Italy
Clin Chim Acta 404:79-85. 2009..The mission of the WG-LEPS is to promote and encourage investigations into errors in laboratory medicine, collect data available on this issue and recommend strategies and procedures for improving patient safety...
- Longitudinal trends in laboratory test utilization at a large tertiary care university hospital in SwedenMirja Mindemark
Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden
Ups J Med Sci 116:34-8. 2011..The aim of the study was to describe and evaluate longitudinal trends in laboratory test utilization over a 7-year period from 2002 to 2008...
- Reference intervals: an updatePaul S Horn
Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH 45221 0025, USA
Clin Chim Acta 334:5-23. 2003..As a result the only difference is the method bias. By using the reference interval width, this bias is eliminated. We argue that the log ratio of the reference interval widths is a good estimate of the variability between groups...
- Revolutionizing clinical microbiology laboratory organization in hospitals with in situ point-of-careStephan Cohen-Bacrie
Fédération de Microbiologie Clinique, Assistance Publique des Hôpitaux de Marseille Pôle des Maladies Infectieuses, Hopital La Timone, Marseille, France
PLoS ONE 6:e22403. 2011..Clinical microbiology may direct decisions regarding hospitalization, isolation and anti-infective therapy, but it is not effective at the time of early care. Point-of-care (POC) tests have been developed for this purpose...
- Appropriateness in programs for continuous quality improvement in clinical laboratoriesMario Plebani
Department of Laboratory Medicine, University Hospital of Padova, Azienda Ospedaliera di Padova, Via Giustiniani, 2, 35128 Padova, Italy
Clin Chim Acta 333:131-9. 2003..Appropriateness plays a key role in programs for quality improvement...
- Minimizing the workup of blood culture contaminants: implementation and evaluation of a laboratory-based algorithmS S Richter
Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Clin Microbiol 40:2437-44. 2002..6% of 71 isolates. The laboratory-based algorithm provided an acceptably accurate means for assessing the clinical significance of potential contaminants recovered from blood cultures...
- Procalcitonin as an early indicator of outcome in sepsis: a prospective observational studyE J Giamarellos-Bourboulis
4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece
J Hosp Infect 77:58-63. 2011..404; 95% CI: 1.385-4.171). It is concluded that PCT cut-off concentrations can contribute to predicting the outcome of sepsis and might be of particular value in identifying patients who would benefit from ICU admission...
- The quality of sputum smear microscopy diagnosis of pulmonary tuberculosis in Dar es Salaam, TanzaniaG S Mfinanga
National Institute for Medical Research, Muhimbili Medical Research Centre, P O Box 3436, Dar es Salaam, Tanzania
Tanzan Health Res Bull 9:164-8. 2007..It is therefore important to strengthen the capacity of laboratory personnel in smear microscopy techniques through supportive supervision and training...
- Pseudallescheria/Scedosporium complex species identification by Matrix-Assisted Laser Desorption Ionization Time-Of-Flight Mass SpectrometryOumar Coulibaly
Laboratoire de Parasitologie Mycologie, CHU Timone, Universite de la Mediterranee, Marseille, France
Med Mycol 49:621-6. 2011..boydii sl. and to validate its use in the routine clinical laboratory for identifying clinically relevant moulds...
- Users' and health service providers' perception on quality of laboratory malaria diagnosis in TanzaniaYahya A Derua
National Institute for Medical Research, Amani Centre, Muheza, Tanzania
Malar J 10:78. 2011..This study was conducted to assess perceptions of users and health-care providers on the quality and utilization of laboratory malaria diagnostic services in six districts from three regions in Tanzania...
- Over-diagnosis of malaria is not a lost causePaul M Masika
Kilimanjaro Christian Medical College, PO 2240, Moshi, Tanzania
Malar J 5:120. 2006..This study assessed the impact of a training programme implemented as part of an intervention trial on diagnostic behaviour of clinicians in a rural district hospital in a low-moderate malaria transmission setting...
- The brain-to-brain loop concept for laboratory testing 40 years after its introductionMario Plebani
Department of Laboratory Medicine, University of Padova, Italy
Am J Clin Pathol 136:829-33. 2011..This review describes the changes and their implications for analysis of errors associated with laboratory testing...
- Laboratory network of excellence: enhancing patient safety and service effectivenessMario Plebani
Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy
Clin Chem Lab Med 44:150-60. 2006..These data should stimulate debate in the scientific community and encourage more clinical laboratories to use the same indicators to improve clinical effectiveness and clinical outcomes within the healthcare service...
- The reporting, classification and grading of quality failures in the medical laboratoryMaurice O'Kane
Clinical Chemistry Laboratory, Altnagelvin Hospital, Londonderry, N Ireland, United Kingdom
Clin Chim Acta 404:28-31. 2009..This confirms the need for ongoing vigilance by laboratories. This classification/grading system is easy to implement and represents a valuable additional tool for monitoring performance...
- Assessment monitoring of laboratory critical values: a College of American Pathologists Q-Tracks study of 180 institutionsElizabeth A Wagar
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, 90095 1732, USA
Arch Pathol Lab Med 131:44-9. 2007..Critical laboratory value reporting is a highly visible and essential key activity for clinical laboratories...
- The landscape of inappropriate laboratory testing: a 15-year meta-analysisMing Zhi
Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 8:e78962. 2013..Systematic differences in initial vs. repeat testing, measurement criteria, and other factors would suggest new priorities for improving laboratory testing...
- Validation of high-risk HPV tests for primary cervical screeningC J L M Meijer
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
J Clin Virol 46:S1-4. 2009..It is expected that the use of these guidelines will facilitate implementation of hrHPV testing in primary cervical screening...
- High-throughput pooling and real-time PCR-based strategy for malaria detectionSteve M Taylor
Department of Epidemiology, Gillings School of Global Public Health, North Carolina, Chapel Hill, North Carolina 27599, USA
J Clin Microbiol 48:512-9. 2010..Our study highlights both substantial discordance between malaria diagnostics and the utility and parsimony of employing a sample pooling strategy for molecular diagnostics in clinical and epidemiologic malaria studies...
- The Tanzania experience: clinical laboratory testing harmonization and equipment standardization at different levels of a tiered health laboratory systemCharles Massambu
Ministry of Health and Social Welfare, Tanzania
Am J Clin Pathol 131:861-6. 2009..This document outlines this process...
- High specificity of line-immunoassay based algorithms for recent HIV-1 infection independent of viral subtype and stage of diseaseJorg Schupbach
University of Zurich, Institute of Medical Virology, Swiss National Center for Retroviruses, Zurich, Switzerland
BMC Infect Dis 11:254. 2011..Here, we sought to further investigate the diagnostic specificity of various Inno-Lia algorithms and to identify factors affecting it...
- The urine circulating cathodic antigen (CCA) dipstick: a valid substitute for microscopy for mapping and point-of-care diagnosis of intestinal schistosomiasisJose Carlos Sousa-Figueiredo
Disease Control Strategy Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
PLoS Negl Trop Dis 7:e2008. 2013..Our manuscript reports on findings at baseline and at the end of a one-year longitudinal treatment study...
- Preanalytical variability: the dark side of the moon in laboratory testingGiuseppe Lippi
Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
Clin Chem Lab Med 44:358-65. 2006....
- Error budget calculations in laboratory medicine: linking the concepts of biological variation and allowable medical errorsA K Stroobants
Department of General Clinical Chemistry Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands
Clin Chim Acta 333:169-76. 2003..Although somewhat difficult to attain, our main goal should be to prevent all possible errors. A good insight on error-prone steps in the laboratory process is essential to achieving a structured system for error reduction...
- The development of a system for the reporting, classification and grading of quality failures in the clinical biochemistry laboratoryMaurice J O'Kane
Clinical Chemistry Laboratory, Altnagelvin Hospital, Londonderry BT47 6SB, Northern Ireland
Ann Clin Biochem 45:129-34. 2008..There is no agreed system for the reporting, classification and grading of the severity of quality failures in the clinical biochemistry laboratory...
- Collective opinion paper on findings of the 2010 convocation of experts on laboratory qualityGreg Cooper
W Gregory Cooper LLC, Denton, TX, USA
Clin Chem Lab Med 49:793-802. 2011..This paper provide a synopsis of the reports from each working group...
- Modelling the dynamics of Plasmodium falciparum histidine-rich protein 2 in human malaria to better understand malaria rapid diagnostic test performanceLouise Marquart
Statistics Unit, Queensland Institute of Medical Research, Herston, Australia
Malar J 11:74. 2012..However, concerns have been raised about the longevity of the PfHRP2 antigenaemia following curative treatment in endemic regions...
- Clinical quality indicators in laboratory medicine: a survey of current practice in the UKJulian H Barth
Department of Clinical Biochemistry, Leeds General Infirmary, Leeds, UK
Ann Clin Biochem 48:238-40. 2011..Clinical outcomes are the current paradigm for assessing the performance of health institutions. In contrast, clinical laboratories are assessed on largely operational criteria...
- The quality of reporting in diagnostic test research: getting better, still not optimalPatrick M M Bossuyt
Clin Chem 50:465-6. 2004
- A field evaluation of formalin-gasoline technique in the concentration of stool for detection of intestinal parasitesNayeb Ali Ahmadi
Parasitology and Mycology Department, Shahid Beheshti University M C, Darband Street, Tajrish, P O Box 19395 4618, Tehran, Iran
Parasitol Res 104:553-7. 2009....
- What does the future hold for clinical microbiology?Didier Raoult
Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille, France
Nat Rev Microbiol 2:151-9. 2004....
- A PCT Sample Preparation System for Proteomic Research and Clinical DiagnosticsFeng Tao; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Development of a Novel Method for Inhibiting Atherosclerosis in DiabetesDavid Clemmons; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Chaperones, ROS systems, & IGF-1:Roles in vascular agingDavid Clemmons; Fiscal Year: 2008..abstract_text> ..
- IGFBP5 AND INTEGRINS AND CONTROLLING IGF1 ACTIONSDavid Clemmons; Fiscal Year: 2002....
- ARTHEROSCLEROSIS IN INSULIN-RESISTANT, HYPERLIPIDEMIC P*David Clemmons; Fiscal Year: 2005....
- MECHANISMS BY WHICH IGF-I STIMULATES SMOOTH MUSCLE CELLSDavid Clemmons; Fiscal Year: 2007..The results may suggest novel strategies for interfering with these processes to alter the progression of atherosclerosis. ..
- International Mobility of HIVHong Ha M Truong; Fiscal Year: 2010....
- Evaluation of Vitamin D Requirements During PregnancyBruce Hollis; Fiscal Year: 2007..unreadable] [unreadable]..
- Clinical Decision Rule to Identify Children with Intra-Abdominal InjuriesJames Holmes; Fiscal Year: 2008..unreadable]..
- Diabetes and Drug-Associated Hyperkalemia: Effect of Laboratory MonitoringMarsha Raebel; Fiscal Year: 2008..The findings will also assist in developing a framework for future studies to evaluate the effects and costs of medication-laboratory monitoring among patients with diabetes. [unreadable] [unreadable] [unreadable] [unreadable]..
- Establishing the Vitamin D Requirements During LactationBruce W Hollis; Fiscal Year: 2010..The findings of this study will generate important new information for health care professionals and policy makers with regard to vitamin D requirements and the potential benefit to both mother and infant. ..
- The role of anxiety sensitivity and smoking in adolescent panic vulnerabilityEllen Leen Feldner; Fiscal Year: 2008..As such, it will inform clinical intervention efforts for both panic and smoking processes among youth. [unreadable] [unreadable] [unreadable]..
- Clinical models for evaluating PREPs for tobacco usersThomas Eissenberg; Fiscal Year: 2008..This proposal's clinical model will likely be an important component of a comprehensive approach to predict if PREPs for tobacco users increase, decrease, or fail to change tobacco's health risks. ..
- Topical Antibiotics to Prevent Lyme DiseaseGary Wormser; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Appropriate Pneumococcal Vaccination in Infants in FijiFiona Russell; Fiscal Year: 2007..The results of this study will form the basis of an effectiveness evaluation following the pilot introduction of pneumococcal immunization into Fiji in 3-5 years time. [unreadable] [unreadable]..
- New Clinical Approaches to Creutzfeldt-Jakob DiseaseMichael Geschwind; Fiscal Year: 2007..Geschwind's training in behavioral neurology and neuroscience, thereby helping him to design and implement future clinical treatment studies for human prion disease and other dementias. ..
- MOLECULAR MECHANISMS OF RENAL FIBROSISERIC NEILSON; Fiscal Year: 2007..This understanding may be key to learning how we can further manipulate their participation in renal fibrosis. ..
- Quality of Life in patients with severe Cystic FibrosisChristopher Goss; Fiscal Year: 2007....
- Targeting mTOR for Cancer TherapyFunda Meric Bernstam; Fiscal Year: 2009..With this study, we not only expect to identify pharmacodynamic markers of response for mTOR inhibitors but also to significantly enhance our understanding of mTOR inhibitors'mechanism of action. ..
- GM-CSF Enhanced Colorectal Cancer Tumor Vaccine ProgramRichard Schulick; Fiscal Year: 2008..abstract_text> ..
- Environmental Effects on Lung Function in Cystic Fibrosis PatientsChristopher Goss; Fiscal Year: 2008..Our proposal will also enhance our understanding of lung growth in CF and represents the initial phase of a program to understand environmental effects on CF lung disease. [unreadable] [unreadable] [unreadable]..
- Mechanisms of immunomodulatory and anti-tumor actions of Polysaccharide KrestinMary L Disis; Fiscal Year: 2010..Results from these studies will help us understand the immune modulating effect of PSK and contribute to the clinical translation of this CAM molecule as an anti-cancer agent and/or a vaccine adjuvant. ..
- Optimizing strategies for universal HIV testingRochelle P Walensky; Fiscal Year: 2010..The scientific basis for early detection of HIV infection and aggressive linkage to care has been successfully laid. The challenge now is to identify effective, affordable, and cost-effective implementation mechanisms. ..
- Mitochondrial sites of reactive oxygen species generation in cells.Martin D Brand; Fiscal Year: 2010....
- New Proteomic Algorithms to Identify Mutant or Modified ProteinsDAVID LEE TABB; Fiscal Year: 2010..We propose new systems for improving proteomics'application to clinical samples by improving identification of modified and mutant protein forms and managing sets of related proteins documentation to promote their widespread use. ..
- IMMUNOREGULATION IN HUMAN STRONGYLOIDIASISMartin Montes; Fiscal Year: 2010..Studies of immunoregulation in strongyloidiasis may also lead to insights needed for addressing the burden of intestinal nematodes, which affect billions of people. ..
- Antiretroviral Therapy and the Hepatitis C VirusKenneth E Sherman; Fiscal Year: 2010....
- New Evidence on the Persistence of High Health SpendingRichard Hirth; Fiscal Year: 2009..We will provide an example of how such estimates can inform the evaluation of risk-adjustment and reinsurance as mechanisms to improve the functioning of small group health insurance markets. ..
- Point-of-Care Microfluidics in Lung CancerMehmet Toner; Fiscal Year: 2009....
- Matrix remodeling in the lung during HIV infectionLYNN SCHNAPP; Fiscal Year: 2009..abstract_text> ..
- Anti-ischemic Resuscitation FluidMartin Bluth; Fiscal Year: 2008..abstract_text> ..
- Improving Lyme disease diagnosis through bioinformaticsRichard Porwancher; Fiscal Year: 2008..This bioinformatic approach has the potential for integrating clinical and serologic diagnostic approaches using a standardized serum bank. ..
- Planning Grant for Institutional Clinical and Translational Science AwardMARY DISIS; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- CLINICAL RESEARCH CENTER FOR NEUROMUSCULAR DISEASESalvatore DiMauro; Fiscal Year: 2007....
- FEASIBILITY OF PRENATAL SCREENING FOR SLO SYNDROMEGeorge Knight; Fiscal Year: 2003..The study will also aid in refining prevalence estimates by race and ethnicity, and will determine whether several rare disorders in the cholesterol biosynthetic pathway would be detectable. ..
- Treatment Models for Primary and Chronic HIV InfectionRochelle Walensky; Fiscal Year: 2005..Rochelle Walensky with a firm basis for career development as an independent, patient-oriented clinical researcher at the interface of these critical areas. ..
- Race, Ethnicity and Quality of Health Care for NewbornsLaurence Baker; Fiscal Year: 2005..Our work will focus on Black-White differences, disparities for Hispanics (including subgroups like Mexican and Puerto Rican), and disparities for Asian and Pacific Islanders. ..
- Tissue Homogenizaton by Pressure Cycling TechnologyFeng Tao; Fiscal Year: 2003..The successful development of the PCT homogenization technology will benefit molecular based analytical procedures in genomics, medical, forensic, agricultural, pharmaceutical, veterinary and clinical applications ..
- HER2 VACCINATION FOR THE TREATMENT OF CANCERMARY DISIS; Fiscal Year: 2004....
- PHARMACOLOGY OF COMBINED EPHEDRINE/CAFFEINE SUPPLEMENTSChristine Haller; Fiscal Year: 2004..The long-term objective for the proposed studies is to develop Dr. Haller into an independent career clinical researcher in this field of study. ..
- HCV Genomic Variability in HIV Infected HemophiliacsKenneth Sherman; Fiscal Year: 2004..Treatment nonresponders will be followed in a prospective cohort study for up to 3 additional years so that the evolution of the virus, and its associated immune response in this group can be evaluated. ..
- Mycobacterium tuberculosis cell wall virulence factorsSusan Dorman; Fiscal Year: 2004..Finally, new information from the proposed self-contained pilot studies will serve as the foundation for future comprehensive dissection of macrophage response pathways affected by specific cell wall components. ..
- Spatial Epidemiology of Syphilis and Gonorrhea in North CarolinaWilliam C Miller; Fiscal Year: 2010..Furthermore, we will obtain critical, new information regarding STI epidemiology in southeastern U.S., a region with disproportionate burden of these infections. ..
- MANAGED CARE AND HEALTH CARE MARKETSLaurence Baker; Fiscal Year: 2003..abstract_text> ..
- PROSPECTIVE INVESTIGATION OF PUMONARY EMBOLISM DX IIRussell Hull; Fiscal Year: 2003..abstract_text> ..
- Preventing Club Drug Use among Rave AttendeesGeorge Yacoubian; Fiscal Year: 2004..abstract_text> ..
- INTEGRATION OF FIBROBLAST FUNCTIONING IN WOUND HEALINGAlan Wells; Fiscal Year: 2003..Understanding the delicate balance of these molecular mechanisms is important for rationally designing interventions to achieve normal wound healing. ..
- Endothelial dysfunction in acute renal ischemiaMICHAEL GOLIGORSKY; Fiscal Year: 2007..Number of publicationsand manuscriptsacceptedfor publication (not to exceed 10) 10 Other items (list): 1. Color illustrations from the grant application 2. Movies - intravital videomicroscopy supplement ..
- Rapid Detection of Mycobacterium tuberculosisSusan Dorman; Fiscal Year: 2007..unreadable] [unreadable] Relevance: Results of these studies will improve our understanding of the laboratory performance and clinical benefit of this test, and lead to improved detection and treatment of TB. [unreadable] [unreadable]..
- REVERSIBLE PATHOLOGY OF THE PLATELET STORAGE LESIONBrian Smith; Fiscal Year: 2001..The long term goal of the project, which combines the synergistic expertise of several established investigators, is to improve the clinical results of platelet transfusion. ..
- INTEGRINS IN ACUTE RENAL FAILUREMICHAEL GOLIGORSKY; Fiscal Year: 2002....
- Microfluidics, Physics and Chemistry of Gordon ConferenceLAURIE LOCASCIO; Fiscal Year: 2005....
- Physiological correlates of auditory perceptionJennifer Lister; Fiscal Year: 2005..Once the processes that underlie behavioral temporal deficits are described, diagnostic and remediation strategies may be designed to identify/target specific areas of weakness in individual older adults. ..
- Platelet-Leukocyte Physiology in Cardiopulmonary BypassBrian Smith; Fiscal Year: 2005..induced by SECC; (3) examine the effects of SECC on human endothelial cells by in vitro modeling, specifically including alterations in tissue factor regulation and the effect of differential complement components ..
- INTRACELLULAR CATIONS AND EXCITOTOXICITYIan Reynolds; Fiscal Year: 2002....
- NF KAPPA B MEDIATED CHEMORESISTANCE IN HUMAN LUNG CANCERDavid Jones; Fiscal Year: 2005..The ultimate goal of this study is to provide the necessary background for the initiation of novel treatment strategies designed to treat patients with advanced lung cancer. ..
- PREVENTION OF VASCULOPATHY AND NEPHROPATHY IN METABOLIC SYNDROMEMichael S Goligorsky; Fiscal Year: 2010..abstract_text> ..
- STATISTICAL METHODS FOR COMMUNITY INTERVENTION TRIALSZiding Feng; Fiscal Year: 2003..The bias and efficiency of this method compared to competing procedures will be examined analytically and via simulation. ..
- EXPRESSION AND FUNCTION OF THE GUANYLIN LIGAND FAMILYMitchell Cohen; Fiscal Year: 2009..Furthermore, these studies will lay the groundwork for translational research involving these peptides as therapeutic agents for fluid overload states. ..
- Safety of Nicotine Reduction StrategyNeal Benowitz; Fiscal Year: 2009..The proposed research is needed to guide governmental regulators as to how best to regulate nicotine in cigarettes and is an essential first step in examining the feasibility of a national regulation program. ..
- HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSESPeter Krause; Fiscal Year: 2001..The density of deer will be estimated in each site. This proposed effort will help define the health burden imposed on people residing in proximity to deer and will contribute to diagnosis and case-management of apparent Lyme disease. ..
- Drug craving: pharmacologic and associative influencesThomas Eissenberg; Fiscal Year: 2006..Given the costs of smoking and the dramatic reduction in these costs when smokers quit smoking, improving the treatment options for all smokers is essential. ..
- POPULATION BASED INVESTIGATIONS OF TUBERCULOSISDavid Alland; Fiscal Year: 2004..Studies of these sequence variations in clinical strains will be used to determine the associations between specific mutations and the phenotypes of infectivity and virulence. ..
- Towards drugs that prevent resistance to the HIV OI, TBDavid Alland; Fiscal Year: 2006..if embB306 mutations affect biosynthesis of LAM, capped LAM, arabinogalactan (AG) or other cell wall components in the presence and absence of EMB. ..
- TUBERCULOSIS GENOTYPING AND EVOLUTIONARY CONSORTIUMDavid Alland; Fiscal Year: 2005..4) To identify and validate an informative set of SNPs for worldwide evolutionary and epidemiological analyses. ..
- Detection of Select Agents in Single-Well AssaysDavid Alland; Fiscal Year: 2007..3. To develop PCR assays that utilize "color-triplet coding" to uniquely label as many as 56 different species-specific molecular beacons. ..
- Nucleic Acid Purification Using Pressure Cycling TechnologyFeng Tao; Fiscal Year: 2007..If successful, this technology could be immediately employed in many fields of life sciences. [unreadable] [unreadable] [unreadable]..