prognosis

Summary

Summary: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

Top Publications

  1. doi Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    Jacques Ferlay
    Section of Cancer Information, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 127:2893-917. 2010
  2. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
  3. doi Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    Roger Stupp
    Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Lancet Oncol 10:459-66. 2009
  4. pmc An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    Ittai Ben-Porath
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:499-507. 2008
  5. doi Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer
    David S Cooper
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Thyroid 19:1167-214. 2009
  6. ncbi Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Jerome Galon
    INSERM U 255, Paris, 75006 France Université Paris Descartes Paris 5, Faculte de Medecine, Paris, 75006 France
    Science 313:1960-4. 2006
  7. ncbi A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    George Adrian Calin
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    N Engl J Med 353:1793-801. 2005
  8. ncbi Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    D J Slamon
    Department of Medicine, U C L A School of Medicine 90024
    Science 244:707-12. 1989
  9. ncbi Hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Liver Unit, Digestive Disease Institute, IDIBAPS, Hospital Cli nic i Provincial, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain
    Lancet 362:1907-17. 2003
  10. pmc Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    Roel G W Verhaak
    The Eli and Edythe L Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Cancer Cell 17:98-110. 2010

Detail Information

Publications524 found, 100 shown here

  1. doi Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    Jacques Ferlay
    Section of Cancer Information, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Int J Cancer 127:2893-917. 2010
    ..7%) and liver cancer (696,000 deaths, 9.2%). Cancer is neither rare anywhere in the world, nor mainly confined to high-resource countries. Striking differences in the patterns of cancer from region to region are observed...
  2. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
    ..The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures...
  3. doi Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    Roger Stupp
    Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Lancet Oncol 10:459-66. 2009
    ..We report the final results with a median follow-up of more than 5 years...
  4. pmc An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    Ittai Ben-Porath
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:499-507. 2008
    ....
  5. doi Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer
    David S Cooper
    The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Thyroid 19:1167-214. 2009
    ..Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in 2006, a large amount of new information has become available, prompting a revision of the guidelines...
  6. ncbi Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Jerome Galon
    INSERM U 255, Paris, 75006 France Université Paris Descartes Paris 5, Faculte de Medecine, Paris, 75006 France
    Science 313:1960-4. 2006
    ..In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies...
  7. ncbi A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    George Adrian Calin
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA
    N Engl J Med 353:1793-801. 2005
    ..We investigated whether microRNA profiles are associated with known prognostic factors in CLL...
  8. ncbi Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    D J Slamon
    Department of Medicine, U C L A School of Medicine 90024
    Science 244:707-12. 1989
    ..The data presented further support the concept that the HER-2/neu gene may be involved in the pathogenesis of some human cancers...
  9. ncbi Hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Liver Unit, Digestive Disease Institute, IDIBAPS, Hospital Cli nic i Provincial, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain
    Lancet 362:1907-17. 2003
    ..Meta-analysis shows that only chemoembolisation improves survival in well-selected patients with unresectable HCC...
  10. pmc Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    Roel G W Verhaak
    The Eli and Edythe L Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Cancer Cell 17:98-110. 2010
    ..We provide a framework that unifies transcriptomic and genomic dimensions for GBM molecular stratification with important implications for future studies...
  11. pmc Supervised risk predictor of breast cancer based on intrinsic subtypes
    Joel S Parker
    Lineberger Comprehensive Cancer Center, Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    J Clin Oncol 27:1160-7. 2009
    PURPOSE To improve on current standards for breast cancer prognosis and prediction of chemotherapy benefit by developing a risk model that incorporates the gene expression-based "intrinsic" subtypes luminal A, luminal B, HER2-enriched, ..
  12. pmc Most random gene expression signatures are significantly associated with breast cancer outcome
    David Venet
    IRIDIA CoDE, Universite Libre de Bruxelles, Brussels, Belgium
    PLoS Comput Biol 7:e1002240. 2011
    ..The methods we present help to overcome this problem...
  13. doi MicroRNAs in Cancer
    Ramiro Garzon
    Department of Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Annu Rev Med 60:167-79. 2009
    ..In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.
  14. doi The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report
    Andrew S Levey
    Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA
    Kidney Int 80:17-28. 2011
    ..It was the position of KDIGO and KDOQI that the definition and classification should reflect patient prognosis and that an analysis of outcomes would answer key questions underlying the debate...
  15. ncbi Neuroblastoma
    John M Maris
    Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    Lancet 369:2106-20. 2007
    ..Finally, we discuss new approaches to treatment, including recently discovered molecular targets that might provide more effective treatment strategies with the potential for less toxicity...
  16. ncbi Neuroblastoma: biological insights into a clinical enigma
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Rev Cancer 3:203-16. 2003
    ..Future therapies will focus increasingly on the genes and biological pathways that contribute to malignant transformation or progression...
  17. doi Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    Eric Van Cutsem
    University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    J Clin Oncol 29:2011-9. 2011
    ..An updated survival analysis, including additional patients analyzed for tumor mutation status, was undertaken...
  18. ncbi Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series
    Christine Desmedt
    Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium
    Clin Cancer Res 13:3207-14. 2007
    ..The aims of this study conducted by TRANSBIG were to independently validate these results and to compare the outcome with clinical risk assessment...
  19. pmc MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma
    Aaron J Schetter
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    JAMA 299:425-36. 2008
    MicroRNAs have potential as diagnostic biomarkers and therapeutic targets in cancer. No study has evaluated the association between microRNA expression patterns and colon cancer prognosis or therapeutic outcome.
  20. ncbi Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
    Junichi Takamizawa
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Res 64:3753-6. 2004
    ..This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration...
  21. ncbi Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    Malcolm J Moore
    Division of Medical Oncology, Princess Margaret Hospital, Toronto, Canada
    J Clin Oncol 25:1960-6. 2007
    Patients with advanced pancreatic cancer have a poor prognosis and there have been no improvements in survival since the introduction of gemcitabine in 1996...
  22. doi Stromal gene expression predicts clinical outcome in breast cancer
    Greg Finak
    McGill Centre for Bioinformatics, 3775 University Street, McGill University, Quebec H3A 2B4, Canada
    Nat Med 14:518-27. 2008
    ..Genes represented in the SDPP reveal the strong prognostic capacity of differential immune responses as well as angiogenic and hypoxic responses, highlighting the importance of stromal biology in tumor progression...
  23. doi Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers
    Ryunosuke Kogo
    Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Res 71:6320-6. 2011
    ..and function of HOTAIR in patients with stage IV colorectal cancer (CRC) who have liver metastases and a poor prognosis. HOTAIR expression levels were higher in cancerous tissues than in corresponding noncancerous tissues and high ..
  24. ncbi The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours
    Peter Goldstraw
    Royal Brompton Hospital, Imperial College, London, United Kingdom
    J Thorac Oncol 2:706-14. 2007
    ..The recommendations of this committee for changes to the T, N, and M descriptors have been published. This report contains the proposals for the new stage groupings...
  25. ncbi MicroRNA expression profiling in prostate cancer
    Kati P Porkka
    Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Cancer Res 67:6130-5. 2007
    ....
  26. doi Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
    Richard W Tothill
    Peter MacCallum Cancer Center, University of Melbourne, Melbourne, Australia
    Clin Cancer Res 14:5198-208. 2008
    ..The study aim to identify novel molecular subtypes of ovarian cancer by gene expression profiling with linkage to clinical and pathologic features...
  27. ncbi Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    Yixin Wang
    Veridex LLC, a Johnson and Johnson Company, San Diego, CA, USA
    Lancet 365:671-9. 2005
    ....
  28. pmc Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    Aleix Prat
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599, USA
    Breast Cancer Res 12:R68. 2010
    ..Here, we comprehensively characterize the recently identified claudin-low tumor subtype...
  29. pmc Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer
    Maggie C U Cheang
    Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, BC, Canada
    J Natl Cancer Inst 101:736-50. 2009
    ..Luminal B tumors have higher proliferation and poorer prognosis than luminal A tumors...
  30. pmc Human papillomavirus and survival of patients with oropharyngeal cancer
    K Kian Ang
    University of Texas M D Anderson Cancer Center, Houston, USA
    N Engl J Med 363:24-35. 2010
    ..Oropharyngeal squamous-cell carcinomas caused by human papillomavirus (HPV) are associated with favorable survival, but the independent prognostic significance of tumor HPV status remains unknown...
  31. doi One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States
    James C Yao
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 26:3063-72. 2008
    ..Clinicians need to be become familiar with the natural history and patterns of disease progression, which are characteristic of these tumors...
  32. doi Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma
    Annika Schaefer
    Department of Biology, Free University, Berlin, Germany
    Int J Cancer 126:1166-76. 2010
    ..Thus, differential miRNAs in prostate cancer are useful diagnostic and prognostic indicators. This study provides a solid basis for further functional analyses of miRNAs in prostate cancer...
  33. pmc DNMT3A mutations in acute myeloid leukemia
    Timothy J Ley
    Department of Genetics, Genome Center, Washington University, St Louis, MO 63110, USA
    N Engl J Med 363:2424-33. 2010
    ..The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown...
  34. ncbi Triple-negative breast cancer: clinical features and patterns of recurrence
    Rebecca Dent
    Department of Medical Oncology, Sunnybrook Health Sciences Center, University of Toronto, Ontario, Canada
    Clin Cancer Res 13:4429-34. 2007
    ..To compare the clinical features, natural history, and outcomes for women with "triple-negative" breast cancer with women with other types of breast cancer...
  35. doi Colorectal cancer
    David Cunningham
    Gastrointestinal Unit, Royal Marsden Hospital National Health Service Foundation Trust, London and Surrey, UK
    Lancet 375:1030-47. 2010
    ..However, biomarker development is essential to aid selection of patients likely to respond to therapy, thereby rationalising treatments and improving outcomes...
  36. pmc MicroRNA expression, survival, and response to interferon in liver cancer
    Junfang Ji
    Liver Carcinogenesis Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 361:1437-47. 2009
    ..Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, and response to interferon alfa in both men and women with the disease...
  37. pmc Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
    G C Donaldson
    Academic Unit of Respiratory Medicine, St Bartholomew s and Royal London School of Medicine and Dentistry, UK
    Thorax 57:847-52. 2002
    ..The aim of this study was to investigate whether these are related...
  38. doi Triple-negative breast cancer
    William D Foulkes
    Departmentof Oncology and Human Genetics, Research Institute of the McGill University Health Centre, and the Lady Davis Institute of the Jewish General Hospital, McGill University, Montreal, QC H2W 1S6, Canada
    N Engl J Med 363:1938-48. 2010
    ..This review focuses on its origin, molecular and clinical characteristics, and treatment...
  39. ncbi Systematic review of microsatellite instability and colorectal cancer prognosis
    S Popat
    MRCP, Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey SM2 5NG, UK
    J Clin Oncol 23:609-18. 2005
    ..studies have investigated the relationship between microsatellite instability (MSI) and colorectal cancer (CRC) prognosis. Although many have reported a better survival with MSI, estimates of the hazard ratio (HR) among studies differ...
  40. pmc Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    Eiichi Sato
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:18538-43. 2005
    ..This unfavorable effect of CD4+ T cells on prognosis was found to be due to CD25+ forkhead box P3 (FOXP3)+ regulatory T cells (Treg; suppressor T cells), as ..
  41. pmc MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer
    Mattia Boeri
    Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, and Unit of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 108:3713-8. 2011
    ..miRNA) expression profiles of lung tumors, normal lung tissues and plasma samples from cases with variable prognosis identified in a completed spiral-CT screening trial with extensive follow-up...
  42. doi Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
    Arnaud D Roth
    Oncosurgery, Geneva UniversityHospital, Geneva, Switzerland
    J Clin Oncol 28:466-74. 2010
    ..We took advantage of PETACC-3, an adjuvant trial with 3,278 patients with stage II to III colon cancer, to evaluate the prognostic value of KRAS and BRAF tumor mutation status in this setting...
  43. doi An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
    Balazs Gyorffy
    Joint Research Laboratory of the Hungarian Academy of Sciences and the Semmelweis University, Semmelweis University 1st Department of Pediatrics, Bókay u 53 54, 1083, Budapest, Hungary
    Breast Cancer Res Treat 123:725-31. 2010
    ..The tool is highly valuable for the preliminary assessment of biomarkers, especially for research groups with limited bioinformatic resources...
  44. ncbi Prognostic and predictive factors in breast cancer by immunohistochemical analysis
    D C Allred
    Department of Pathology, University of Texas Health Science Center, San Antonio 78284, USA
    Mod Pathol 11:155-68. 1998
    ..In the future, these and other factors will be incorporated into a prognostic index that will better reflect the biologic diversity of breast cancer and that will more accurately predict clinical outcome...
  45. ncbi The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
    L Bingle
    Tumour Targeting Group, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK
    J Pathol 196:254-65. 2002
    ..This review presents evidence for the number and/or distribution of TAMs being linked to prognosis in different types of human malignancy...
  46. doi Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    Cornelia Liedtke
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 1439, USA
    J Clin Oncol 26:1275-81. 2008
    ..In this study, we compared response to neoadjuvant chemotherapy and survival between patients with TNBC and non-TNBC...
  47. ncbi Tumour-educated macrophages promote tumour progression and metastasis
    Jeffrey W Pollard
    Center for the Study of Reproductive Biology and Women s Health and the Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    Nat Rev Cancer 4:71-8. 2004
  48. pmc From RECIST to PERCIST: Evolving Considerations for PET response criteria in solid tumors
    Richard L Wahl
    Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0817, USA
    J Nucl Med 50:122S-50S. 2009
    ..1. This article also reviews qualitative and quantitative approaches to metabolic tumor response assessment with (18)F-FDG PET and proposes a draft framework for PET Response Criteria in Solid Tumors (PERCIST), version 1.0...
  49. ncbi Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
    Christos Sotiriou
    Functional Genomics and Translational Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
    J Natl Cancer Inst 98:262-72. 2006
    ..We examined whether histologic grade was associated with gene expression profiles of breast cancers and whether such profiles could be used to improve histologic grading...
  50. doi The humoral immune system has a key prognostic impact in node-negative breast cancer
    Marcus Schmidt
    Department of Obstetrics and Gynecology, Medical School, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:5405-13. 2008
    ..83; 95% CI, 0.7-0.97). Thus, we could show in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast...
  51. ncbi Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials
    L Gaspar
    Wayne State University, Detroit, MI 48201, USA
    Int J Radiat Oncol Biol Phys 37:745-51. 1997
    ....
  52. ncbi Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies
    Matthias Egger
    Department of Social and Preventive Medicine, University of Bern, CH 3012 Bern, Switzerland
    Lancet 360:119-29. 2002
    Insufficient data are available from single cohort studies to allow estimation of the prognosis of HIV-1 infected, treatment-naive patients who start highly active antiretroviral therapy (HAART)...
  53. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
    ..We aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy Oncology Group (RTOG)...
  54. ncbi Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    D J Slamon
    Science 235:177-82. 1987
    ..These data indicate that this gene may play a role in the biologic behavior and/or pathogenesis of human breast cancer...
  55. ncbi MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
    Mark Bloomston
    Division of Surgical Oncology, James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, USA
    JAMA 297:1901-8. 2007
    ..While global microRNA (miRNA) expression patterns of many embryologic, physiologic, and oncogenic processes have been described, description of the role of miRNAs in ductal adenocarcinoma of the pancreas is lacking...
  56. pmc Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures
    Pratyaksha Wirapati
    Swiss Institute of Bioinformatics, Batiment Genopode, University of Lausanne, 1015 Lausanne, Switzerland
    Breast Cancer Res 10:R65. 2008
    Breast cancer subtyping and prognosis have been studied extensively by gene expression profiling, resulting in disparate signatures with little overlap in their constituent genes...
  57. pmc Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease
    J J Soler-Cataluña
    Unidad de Neumología, Servicio de Medicina Interna, Hospital General de Requena, Paraje Casablanca s n 46340, Requena Valencia, Spain
    Thorax 60:925-31. 2005
    ..However, little is known about the prognostic consequences of these exacerbations. A study was undertaken to investigate whether severe acute exacerbations of COPD exert a direct effect on mortality...
  58. ncbi Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    Soonmyung Paik
    Division of Pathology, Operations Center, and Biostatistical Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:3726-34. 2006
    ..The relationship between the RS and chemotherapy benefit is not known...
  59. pmc Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis
    Tetsuya Ueda
    Department of Molecular Virology, Immunology, Ohio State University, Columbus, OH 43210, USA
    Lancet Oncol 11:136-46. 2010
    ..have shown that many microRNAs are expressed aberrantly and correlate with tumorigenesis, progression, and prognosis of various haematological and solid tumours...
  60. pmc Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group
    Mitch Dowsett
    Department of Biochemistry, Royal Marsden Hospital and Breakthrough Breast Cancer Centre, Fulham Road, London, UK
    J Natl Cancer Inst 103:1656-64. 2011
    ..Potential uses include prognosis, prediction of relative responsiveness or resistance to chemotherapy or endocrine therapy, estimation of ..
  61. ncbi Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    Nozomu Yanaihara
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 9:189-98. 2006
    ..These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer...
  62. doi Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis
    Nobuyoshi Kosaka
    Section for Studies on Metastasis, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 101:2087-92. 2010
    ..In this review, we summarize the usefulness of circulating miRNA for cancer diagnosis, prognosis, and therapeutics...
  63. pmc Prognosis Research Strategy (PROGRESS) 3: prognostic model research
    Ewout W Steyerberg
    Department of Public Health, Erasmus MC, Rotterdam, Netherlands
    PLoS Med 10:e1001381. 2013
    ....
  64. ncbi Treatment of acute lymphoblastic leukemia
    Ching Hon Pui
    Department of Hematology and Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    N Engl J Med 354:166-78. 2006
  65. pmc Prognosis of patients with HIV-1 infection starting antiretroviral therapy in sub-Saharan Africa: a collaborative analysis of scale-up programmes
    Margaret May
    Department of Social Medicine, University of Bristol, Bristol, UK
    Lancet 376:449-57. 2010
    ..We developed two prognostic models to estimate the probability of death in patients starting ART in sub-Saharan Africa...
  66. ncbi Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade
    Sherene Loi
    Jules Bordet Institute Machine Learning Group, Universite Libre de Bruxelles, Brussels, Belgium
    J Clin Oncol 25:1239-46. 2007
    ..However, although the basal and the ErbB2 subtypes are repeatedly recognized, identification of estrogen receptor (ER) -positive subtypes has been inconsistent. Therefore, refinement of their molecular definition is needed...
  67. doi Stromal gene signatures in large-B-cell lymphomas
    G Lenz
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 359:2313-23. 2008
    ..Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear...
  68. doi Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype
    Maggie C U Cheang
    Genetic Pathology Evaluation Centre, Vancouver Coastal Health Research Institute, British Columbia Cancer Agency, and University of British Columbia, Vancouver, British Columbia, Canada
    Clin Cancer Res 14:1368-76. 2008
    Basal-like breast cancer is associated with high grade, poor prognosis, and younger patient age...
  69. doi Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group
    Patrick Y Wen
    Center for Neuro Oncology, Dana Farber Brigham and Women s Cancer Center, SW430D, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 28:1963-72. 2010
    ..In this proposal, we present the recommendations for updated response criteria for high-grade gliomas...
  70. ncbi Genomic aberrations and survival in chronic lymphocytic leukemia
    H Dohner
    Department of Internal Medicine III University of Ulm, Germany
    N Engl J Med 343:1910-6. 2000
    ..We used this method to identify chromosomal abnormalities in patients with chronic lymphocytic leukemia and assessed their prognostic implications...
  71. ncbi A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival
    M Lacroix
    Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    J Neurosurg 95:190-8. 2001
    ..Gross-total tumor resection is associated with longer survival in patients with GBM, especially when other predictive variables are favorable...
  72. ncbi Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    Chung Mau Lo
    Center for the Study of Liver Disease, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China
    Hepatology 35:1164-71. 2002
    ..In conclusion, in Asian patients with unresectable hepatocellular carcinoma, transarterial Lipiodol chemoembolization significantly improves survival and is an effective form of treatment...
  73. doi Ki67 in breast cancer: prognostic and predictive potential
    Rinat Yerushalmi
    Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada
    Lancet Oncol 11:174-83. 2010
    ....
  74. ncbi Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer
    Anna V Ivshina
    Genome Institute of Singapore, Singapore
    Cancer Res 66:10292-301. 2006
    ..Our findings show that a genetic grade signature can improve prognosis and therapeutic planning for breast cancer patients, and support the view that low- and high-grade disease, as ..
  75. ncbi Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    Heidi S Phillips
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Cell 9:157-73. 2006
    ..Poor prognosis subclasses exhibit markers either of proliferation or of angiogenesis and mesenchyme...
  76. pmc Assessing the performance of prediction models: a framework for traditional and novel measures
    Ewout W Steyerberg
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Epidemiology 21:128-38. 2010
    ..Other measures of performance may be warranted in specific applications, such as reclassification metrics to gain insight into the value of adding a novel predictor to an established model...
  77. ncbi Evaluation of the quality of prognosis studies in systematic reviews
    Jill A Hayden
    Institute for Work and Health, University of Toronto, and Mount Sinai Hospital, Toronto, Ontario, Canada
    Ann Intern Med 144:427-37. 2006
    ..To provide valid assessments of answers to prognostic questions, systematic reviews must appraise the quality of the available evidence. However, no standard quality assessment method is currently available...
  78. pmc Inferring pathway activity toward precise disease classification
    Eunjung Lee
    Department of Bio and Brain Engineering, KAIST, Daejeon, South Korea
    PLoS Comput Biol 4:e1000217. 2008
    ..e., non-conditional) definition of pathways. Within a pathway, the identified CORGs may facilitate the development of better diagnostic markers and the discovery of core alterations in human disease...
  79. ncbi CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group
    Michael Pfreundschuh
    University Clinic of Saarland, Homburg, Germany
    Lancet Oncol 7:379-91. 2006
    ..doxorubicin, vincristine, and prednisone)-like chemotherapy regimens in young patients with good-prognosis diffuse large-B-cell lymphoma remains to be defined...
  80. ncbi Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols
    Stefan S Bielack
    Klinik und Poliklinik für Kinderheilkunde, Pädiatrische Hämatologie Onkologie, Universitatsklinikum, Munster, Germany
    J Clin Oncol 20:776-90. 2002
    ..To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localized extremity disease...
  81. doi A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
    Pierre Farmer
    Swiss National Centre of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Epalinges s Lausanne, Switzerland
    Nat Med 15:68-74. 2009
    ..These findings identify a previously undescribed resistance mechanism to FEC treatment and suggest that antistromal agents may offer new ways to overcome resistance to chemotherapy...
  82. ncbi Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
    Christine P Hans
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Blood 103:275-82. 2004
    ..0001). In summary, immunostains can be used to determine the GCB and non-GCB subtypes of DLBCL and predict survival similar to the cDNA microarray...
  83. doi Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer
    Steven J Cohen
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 26:3213-21. 2008
    ..We tested the hypothesis that circulating tumor cells (CTCs) could predict clinical outcome in patients with mCRC...
  84. doi Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes
    Christine Desmedt
    Medical Oncology Department, Jules Bordet Institute
    Clin Cancer Res 14:5158-65. 2008
    ..Here we aimed to perform a comprehensive meta-analysis integrating both clinicopathologic and gene expression data, focusing on the main molecular subtypes...
  85. ncbi Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    Jessica B O'Connell
    Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Ave, Rm 72 215 CHS, Los Angeles, CA 90095, USA
    J Natl Cancer Inst 96:1420-5. 2004
    ..Using nationally representative Surveillance, Epidemiology, and End Results (SEER) data, we compared survival rates associated with colon cancer stages defined according to both AJCC systems...
  86. doi Chronic obstructive pulmonary disease phenotypes: the future of COPD
    MeiLan K Han
    University of Michigan Pulmonary and Critical Care, 1500 E Medical Center Drive, 3916 Taubman, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 182:598-604. 2010
    ..We have much yet to learn, but establishing a common language for future research will facilitate our understanding and management of the complexity implicit to this disease...
  87. ncbi ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making
    H J Schmoll
    Department of Oncology Haematology, Martin Luther University Halle, Germany
    Ann Oncol 23:2479-516. 2012
    ..This ESMO guideline is recommended to be used as the basis for treatment and management decisions...
  88. ncbi Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    Nicholas J Vogelzang
    University of Chicago, Cancer Research Center, 5841 South Maryland Ave, Chicago, IL 60637, USA
    J Clin Oncol 21:2636-44. 2003
    ..We conducted a phase III trial to determine whether treatment with pemetrexed and cisplatin results in survival time superior to that achieved with cisplatin alone...
  89. ncbi Hypoxia in cancer: significance and impact on clinical outcome
    Peter Vaupel
    Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Cancer Metastasis Rev 26:225-39. 2007
    ..g., BOLD). Clinical experience with these methods regarding patient prognosis is so far only limited...
  90. pmc Medulloblastoma comprises four distinct molecular variants
    Paul A Northcott
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 29:1408-14. 2011
    ..We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups...
  91. doi Treatment of HER2-positive breast cancer: current status and future perspectives
    Carlos L Arteaga
    Breast Cancer Research Program, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, 1310 24th Avenue South, Nashville, TN 37212 2637, USA
    Nat Rev Clin Oncol 9:16-32. 2011
    ....
  92. ncbi Nasopharyngeal carcinoma
    William I Wei
    Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Lancet 365:2041-54. 2005
    ..The quantity of EBV DNA detected in blood indicates the stage and prognosis of the disease...
  93. doi Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis
    Michael Haase
    Department of Nephrology and Intensive Care Medicine, Charite University Medicine, Berlin, Germany
    Am J Kidney Dis 54:1012-24. 2009
    ..Neutrophil gelatinase-associated lipocalin (NGAL) appears to be a promising biomarker for the early diagnosis of acute kidney injury (AKI); however, a wide range in its predictive value has been reported...
  94. ncbi Prognostic significance of morphologic parameters in renal cell carcinoma
    S A Fuhrman
    Am J Surg Pathol 6:655-63. 1982
    ..Nuclear grade was the most significant prognostic criterion for the outcome of Stage I renal cell carcinoma...
  95. doi MicroRNA expression profiles in serous ovarian carcinoma
    Eun Ji Nam
    Women s Cancer Clinic, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea
    Clin Cancer Res 14:2690-5. 2008
    ..We assessed the expression of microRNA and the association between microRNA expression and the prognosis of serous ovarian carcinoma.
  96. doi Upregulation of the long non-coding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis
    Fang Jun Chen
    Department of Surgical Oncology, Affiliated Nanjing Hospital of Nanjing Medical University and Oncology Center of Nanjing Medical University, Nanjing, Jiangsu, China
    Mol Carcinog 52:908-15. 2013
    ..HOTAIR correlation with clinicopathological features and prognosis was also analyzed...
  97. doi Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer
    Pamela J Goodwin
    Mount Sinai Hospital, 1284 600 University Ave, Toronto, Ontario M5G 1X4, Canada
    J Clin Oncol 27:3757-63. 2009
    ..Such effects are biologically plausible given the presence of vitamin D receptors in breast cancer cells, which act as nuclear transcription factors to regulate gene activity...
  98. ncbi Gene expression profiling predicts clinical outcome of breast cancer
    Laura J van 't Veer
    Division of Diagnostic Oncology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    Nature 415:530-6. 2002
    ..to identify a gene expression signature strongly predictive of a short interval to distant metastases ('poor prognosis' signature) in patients without tumour cells in local lymph nodes at diagnosis (lymph node negative)...
  99. doi Head and neck cancer
    Athanassios Argiris
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15232, USA
    Lancet 371:1695-709. 2008
    ..We review the epidemiology, molecular pathogenesis, diagnosis and staging, and the latest multimodal management of squamous cell carcinoma of the head and neck...
  100. doi Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
    Zhe Yang
    Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Zhejiang, China
    Ann Surg Oncol 18:1243-50. 2011
    ..The aim of the present study is to examine the expression pattern of HOTAIR in hepatocellular carcinoma (HCC) and its clinical significance as well as its biological role in tumor progression...
  101. pmc Dicer, Drosha, and outcomes in patients with ovarian cancer
    William M Merritt
    University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    N Engl J Med 359:2641-50. 2008
    ..We studied Dicer and Drosha, components of the RNA-interference machinery, in ovarian cancer...

Research Grants83

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..Nevertheless, the prognosis of patients with acute myocardial infarction remains strongly related to the amount of tissue destroyed during I/..
  3. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..TxRd1 is overexpressed in many human cancers and these elevated levels of TxRd1 have been associated with poor prognosis due to enhanced cellular resistance to chemo- and radiation therapy...
  4. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..The results may lead to new drugs and interventions to improve eating behavior, and help establish unbiased indicators of obesity risk and prognosis for use in research and clinical settings.
  5. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..At present, there is no approved therapy for this condition and prognosis is uniformly poor...
  6. VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2014
    ..women operated on for breast cancer, it was recently reported that low plasma retinol strongly predicts poorer prognosis in patients...
  7. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..tumors is the amplification of the MYCN oncogene, which strongly correlates with more aggressive tumors and poor prognosis of late stage disease...
  8. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..IAP), survivin, is not detected in normal urothelium and its expression in bladder cancer correlates with poor prognosis. The angiogenic factor, VEGF is overexpressed in TCC and may play an important role in the pathogenesis of TCC ..
  9. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2012
    ..more prone to aggressive forms of the disease that are difficult to treat effectively and have a poor clinical prognosis. Non-small cell lung cancer (NSCLC) is the most common form of lung cancer...
  10. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..Despite the grim prognosis associated with the disease, however, we know little about the mechanism of injury...
  11. JoAnn Sekiguchi; Fiscal Year: 2014
    ..The prognosis for this childhood disease is poor, and most patients do not survive beyond their teens...
  12. MR Monitoring of PTC124 Treatment in DMD
    KRISTA H VANDENBORNE; Fiscal Year: 2010
    ..Despite the poor prognosis for patients with muscular dystrophy, therapeutic interventions have been lacking, and outcome measures for ..
  13. ELIZABETH ANN EKLUND; Fiscal Year: 2016
    ..because decreased Icsbp-expression, Fas-resistance, and increased bcatenin activity are associated with poor prognosis in chronic myeloid leukemia (CML)...
  14. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..Brain metastasis indicates poor prognosis in several major malignancies...
  15. Identification of Proteins Important for Male Osteoporosis
    Hong Wen Deng; Fiscal Year: 2013
    ..PBMs) of this study may be used to design customary diagnostic protein antibody chips and/or protein markers for prognosis of male osteoporosis...
  16. Robert W Burgess; Fiscal Year: 2016
    ..loci will improve our understanding of CMT2D mechanisms, suggest therapeutic strategies, and enhance diagnosis/prognosis of CMT2D patients...
  17. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..MCL is an aggressive form of B-cell NHL with a very poor prognosis. MCL comprises 5-10% of NHL cases, has a median survival of about 4 years, and a long- term survival rate of ..
  18. DAVID MARSHALL GUIDOT; Fiscal Year: 2014
    ..Although the development of effective anti-retroviral therapies has improved the prognosis for HIV-1-infected individuals, it remains an incurable chronic illness that causes great morbidity and ..
  19. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ..Thus, the prognosis for this disease is more ominous than for many common types of cancer such as breast, prostate, and colon...
  20. Tatiana Efimova; Fiscal Year: 2014
    ..Cutaneous squamous cell carcinoma (SCC) is the second most common cancer in the United States that exhibits poor prognosis in advanced stages...
  21. Ourania M Andrisani; Fiscal Year: 2015
    ..liver cancer, new and effective therapies are needed, as well as new biomarkers for molecular classification and prognosis of the disease...
  22. J Evan Sadler; Fiscal Year: 2016
    ..For example, the prognosis for many hematologic malignancies continues to be poor...
  23. Alfonso Bellacosa; Fiscal Year: 2014
    ..cloned mammals as well as in cancer and thus have implications for both stem cell biology and cancer diagnosis/prognosis/treatment...
  24. Multivariate CART for survival with dental applications
    Martha E Nunn; Fiscal Year: 2013
    ..Hence, it is essential to utilize dental prognosis in the development of any dental treatment plan...
  25. Molecular Pathogenesis of MDS and CMML
    Jaroslaw P Maciejewski; Fiscal Year: 2013
    ..In this proposal we plan to test the clinical utility of SNP-A karyotyping and establish its impact on prognosis, clinical phenotype and the discovery of new molecular targets in MDS...
  26. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
    ..miRNA profiles have been correlated to particular tumors, based on their cell of origin, and in some cases to prognosis (Lu et al., 2005;He et al., 2005;Yanaihara et al., 2006)...
  27. PROSPECTIVE STUDIES OF DIET AND CANCER IN MEN AND WOMEN
    Walter C Willett; Fiscal Year: 2010
    ..The findings will contribute importantly to the prevention and prognosis of major cancers of men and women.
  28. Sex-Hormones and the TMPRSS2: ERG Fusion in Prostate Cancer Progression
    Lorelei Mucci; Fiscal Year: 2013
    ..and emerging data (including our own) suggest men with tumors with the translocation tend to have a worse cancer prognosis. The regulation of TMPRSS2 by androgens and possibly estrogens is intriguing and illuminates a potential ..
  29. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..We will validate our candidate markers using immunoassays and MRM and thereby gain further insight into prognosis of aortic dissection...
  30. Role of Stat3 in Breast Cancer Tumorigenesis
    Jacqueline F Bromberg; Fiscal Year: 2010
    ..50% of breast cancer-derived cell lines and in primary breast adenocarcinomas and likely correlates with poor prognosis. The evidence that activated Stat3 contributes mechanistically to breast tumorigenesis is based on cell line ..
  31. Cong Yan; Fiscal Year: 2014
    ..long-term goal of this work is to identify secretory protein biomarkers for lung adenocarcinoma diagnosis and prognosis in animals and in humans...
  32. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..Despite technological advances in neurosurgery, chemotherapy and radiation therapy, the prognosis for patients with these tumors remains variable and is relatively poor in infants and adult patients with ..
  33. Optimizing Chronic Disease Prevention and Management in Advanced Dementia
    Jennifer Tjia; Fiscal Year: 2010
    ..Over half of the 1.6 million residents of US NHs have dementia, and those with advanced dementia have a prognosis comparable to that of metastatic breast cancer or stage IV heart failure...
  34. Edward J Pearce; Fiscal Year: 2016
    ..Th2 effector cells improves the prognosis during chronic schistosomiasis...
  35. Rajiv Agarwal; Fiscal Year: 2016
    ..Long-term goal: The overall goal of this study in Veterans with CKD is to investigate target organ damage, prognosis, and mechanisms of "masked hypertension ", defined by an average awake ambulatory pressure of 125/75 mm Hg or ..
  36. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..Suppression of miR-122 is a signature of HCCs with poor prognosis and metastasis...
  37. Edward A Neuwelt; Fiscal Year: 2015
    ..problem in the Veterans Administration patient population, and are associated with high morbidity and poor prognosis. Current treatments for brain metastasis such as radiotherapy with or without chemotherapy have only short- term ..
  38. ANASTACIA GRIEGO; Fiscal Year: 2016
    ..Additionally, we will have learned critical aspects of the interplay between host and virus that may underlie progression to cancer and/or prognosis of HPV[+] lesions.
  39. Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia
    Andrew Napper; Fiscal Year: 2012
    ..fusion of MLL and the transcription factor AF4 (ALL1 fused gene from chromosome 4) leads to a particularly grim prognosis, especially in infant acute lymphocytic leukemia (ALL), where it is found in half of all cases and results in a ..
  40. Multiplexed DNA Origami-Based Biomarker Detection Assay for Early Dx of Arthritis
    John E Mueller; Fiscal Year: 2013
    ..Osteoarthritis Biomarkers Network has classified these biomarkers regarding their applicability to OA diagnosis, prognosis and efficacy of treatment...
  41. Rafael Bejar; Fiscal Year: 2016
    ..The prognosis for patients with MDS is highly variable, with some only mildly affected while others succumb within months of ..
  42. Zipcode based nano-imaging of hypertensive pulmonary arteries
    Rubin M Tuder; Fiscal Year: 2010
    ..When present, it carries a bad prognosis. The main challenge in the field of pulmonary hypertension is the ability to diagnose the disease without having ..
  43. Development of a novel method for inhibiting diabetic retinopathy
    David R Clemmons; Fiscal Year: 2012
    ..functions by a mechanism that is different than those drugs and therefore has the potential to improve the prognosis of this disease in 2/3 of the affected patients...
  44. Bjorn C Knollmann; Fiscal Year: 2016
    ..While there is a rough relationship between prognosis and the degree of cardiac hypertrophy and fibrosis, this genotype/phenotype correlation is weak...
  45. Anna Tate Riegel; Fiscal Year: 2015
    ..AIB1 is a protein highly expressed in human breast cancer that predicts poor prognosis and reduced survival...
  46. Prevention of Esophageal Cancer with Berries
    Gary Stoner; Fiscal Year: 2013
    ..This disease has a poor prognosis with a 5-year survival rate of about 12%...
  47. Role of Id1 in NSCLC Progression and Metastasis
    Srikumar P Chellappan; Fiscal Year: 2013
    ..and metastasis of NSCLC in smokers and non-smokers and to assess whether elevated Id1 correlates with poor prognosis. We believe that these studies will identify novel pathways that are involved in the genesis and progression of ..
  48. Wei Xing Zong; Fiscal Year: 2016
    ..those recently from my laboratory have demonstrated that elevated SCCA1 expression is associated with poorer prognosis in numerous advanced human cancers such as squamous cell carcinomas of lung, head and neck, and esophagus, as ..
  49. CTRIP: Molecular phenotypes of rapidly progressive idiopathic pulmonary fibrosis
    Galen B Toews; Fiscal Year: 2010
    ..has helped to distinguish disorders which are responsive to therapy from those which are associated with a poor prognosis and are relatively unresponsive to known therapies...
  50. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz-Martin; Fiscal Year: 2012
    ..carcinogenesis;3) explore the predictive value of Trim32/Piasy status in human skin and head and neck SCC prognosis as a basis for future strategies for molecular targeting of Trim32/Piasy interactions or downstream effectors in ..
  51. Robert H Squires; Fiscal Year: 2016
    ..and pathogenesis, optimal methods of diagnosis and treatment, and factors that influence disease severity and prognosis. This competitive renewal proposal from the Pittsburgh Cholestatic Liver Disease Consortium at Children's ..
  52. Sanjay Tyagi; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Classifying disease stage and elucidating a prognosis, which allow the most effective medical intervention, are unattainable when the underlying pathological changes, or the correlates of stage and ..
  53. Song Yao; Fiscal Year: 2015
    ..cancer patients who received AI therapy in the Pathways Study, a prospective cohort study of breast cancer prognosis in the Kaiser Permanente Northern California (KPNC) Medical Care Program, enrolled from 2006-2013 and followed ..
  54. microRNAs as novel biomarkers for management of breast cancer
    LORENZO SEMPERE; Fiscal Year: 2012
    ..and, consequently, miRNAs are being regarded as promising biomarkers for early detection, diagnosis and/or prognosis. We and others have linked a small subset of miRNAs to BrCa using whole breast tissue biopsies as RNA source for ..
  55. Autophagy in Brain Tumor
    Jin Ming Yang; Fiscal Year: 2013
    ..Despite advances in the treatment of GBM, the prognosis of patients with this devastating disease remains poor...
  56. Endogenous Cardiac Glycosides in AASK
    Brad C Astor; Fiscal Year: 2010
    ..Further research in this area has the potential to identify new targets for prognosis and treatment to reduce the elevated incidence of cardiovascular disease in this high-risk population...
  57. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..Even when the diagnosis is certain, the tools to offer prognosis or personalize therapy are often lacking...
  58. Guido Musch; Fiscal Year: 2014
    ..VILI) contributes to the morbidity and mortality from ALI, interventions that reduce VILI could improve the prognosis of patients with ALI...
  59. Reza Dana; Fiscal Year: 2016
    ..However, the precise molecular mechanisms that dictate their poor prognosis remain incompletely understood...
  60. PDGF-Receptor regulation in Cocaine and Tat mediated Smooth Muscle Hyperplasia
    Navneet Kaur Dhillon; Fiscal Year: 2012
    ..Unfortunately, despite major clinical advances in therapy over the past few years, the prognosis of HPAH remains poor and patients end up dying from PAH rather than complications related to HIV-Infection...
  61. Developing Novel Serological Biomarkers for Autoimmune Liver Diseases
    Xuhang Li; Fiscal Year: 2013
    ..Disease diagnosis/prognosis relies heavily on clinical presentations as well as invasive and resource-consuming biopsy-based histopathology...
  62. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2012
    ..Our study responds to this need by measuring CHD events, evaluating their prognosis and management in a geographically-defined population...
  63. Combined raman spectroscopy-optical tomagraphy for complete diagnosis of skin can
    Anita Mahadevan Jansen; Fiscal Year: 2009
    ..e., complete resection) are the keys to gain a favorable prognosis. Current diagnostic methods for skin cancers rely on physical examination in conjunction with skin biopsy, ..
  64. Targeting the leukemia microenvironment by CXCR4 inhibition in stem cell transpla
    Marina Y Konopleva; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The prognosis of patients with relapsed acute myeloid leukemia (AML) is extremely poor...
  65. Ultrasound guided site-specific gene delivery in prostate cancer
    Pier Paolo Claudio; Fiscal Year: 2010
    ..Despite the progress of modern radiation techniques in largely improving the prognosis of patients with prostate adenocarcinoma, the maximum benefit that can be achieved with conventional radiation ..
  66. MOLECULAR MARKERS OF PROGNOSIS IN MEDULLOBLASTOMA
    SANDRA BIGNER; Fiscal Year: 2000
    ..Abstract) Medulloblastoma, the most common malignant central nervous system neoplasm in children, has a dismal prognosis despite multi-institutional clinical trials using increasingly sophisticated neurosurgical and therapeutic ..
  67. Shared Decision-Making in End-Stage Heart & Lung Disease
    Mark Sullivan; Fiscal Year: 2005
    ..Both illnesses have an uncertain prognosis that poses a major barrier to shared decision-making and the timely initiation of end of life care...
  68. Urinary Biomarkers for Recovery After Acute Kidney Injury and Prognosis in Hospit
    ISAAC ELI HALL; Fiscal Year: 2010
    ..objective of this research proposal, entitled "Urinary biomarkers for recovery after acute kidney injury and prognosis in hospitalized patients," is to evaluate the relationship between early urinary biomarker levels and subsequent ..
  69. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Serum markers of infection and inflammation have been associated with both incident myocardial infarction (Ml) and prognosis after Ml, but very little data about the relationship of these markers to stroke incidence or prognosis is ..
  70. MENTAL ILLNESS IN THE ELDERLY--DIAGNOSTIC TESTING
    Andrew Leuchter; Fiscal Year: 1999
    ..In addition, we propose new initiatives to identify physiologic indicators of prognosis in dementia and depression, and to develop physiologic predictors of antidepressant treatment response...
  71. Effectiveness of an Enhanced Adaptive Continuing Care Model for Cocaine Dependenc
    James R McKay; Fiscal Year: 2010
    ..First, all patients should be enrolled in the intervention, not just the better prognosis patients who complete an initial phase of care...
  72. Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
    John T McDevitt; Fiscal Year: 2012
    ..Despite significant advances in surgical procedures and treatment, the long-term prognosis for patients with OSCC remains poor, with a 5-year survival rate at approximately 50% which is among the lowest ..
  73. OSCCAR: Ocean State Crohn's and Colitis Area Registry
    MARJORIE MERRICK; Fiscal Year: 2012
    ..Despite the availability of medical therapies, the long-term prognosis of IBD is widely heterogeneous...
  74. Micromagnetic Aptamer PCR System for Ultrasensitive Multiplexed Protein Detection
    HYONGSOK TOM SOH; Fiscal Year: 2010
    For many diseases, effective diagnosis and prognosis depends on the ability to quantitatively measure protein biomarkers present at low concentrations in clinical samples...
  75. Dietary lignan effects on hormone, growth, and signaling factors in breast tumors
    Susan McCann; Fiscal Year: 2009
    ..ER status, as well as a number of other tumor characteristics, has been associated with breast cancer prognosis. Although experimental evidence supports the potential for dietary lignans to favorably affect many of these ..
  76. Transnasal Esophagoscopy vs. Esophageal Capsule Endoscopy for Barrett's Screening
    Amitabh Chak; Fiscal Year: 2010
    ..of esophageal adenocarcinoma has increased dramatically, over three fold in the past three decades, while the prognosis of this cancer has remained poor...