Genomes and Genes
cd4 lymphocyte count
Summary: The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
Publications400 found, 100 shown here
- CD4+ count-guided interruption of antiretroviral treatmentW M El-Sadr
Division of Infectious Diseases, Harlem Hospital Center and Columbia University, New York, NY 10037, USA
N Engl J Med 355:2283-96. 2006..Despite declines in morbidity and mortality with the use of combination antiretroviral therapy, its effectiveness is limited by adverse events, problems with adherence, and resistance of the human immunodeficiency virus (HIV)...
- Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysisDeborah Donnell
Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Lancet 375:2092-8. 2010..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
- Early antiretroviral therapy and mortality among HIV-infected infantsAvy Violari
Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa
N Engl J Med 359:2233-44. 2008..We investigated antiretroviral-treatment strategies in the Children with HIV Early Antiretroviral Therapy (CHER) trial...
- Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort studyIlesh V Jani
Instituto Nacional da Saúde, Maputo, Mozambique
Lancet 378:1572-9. 2011..We implemented point-of-care counting of CD4 cells in Mozambique and assessed the effect on loss to follow-up before immunological staging and treatment initiation...
- Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosisFrancois Xavier Blanc
Pneumology Unit, Internal Medicine Department, Bicetre Hospital, Assistance Publique Hopitaux de Paris, Le Kremlin Bicetre, France
N Engl J Med 365:1471-81. 2011..Robust data are lacking with regard to the timing for the initiation of antiretroviral therapy (ART) in relation to the start of antituberculosis therapy...
- Timing of antiretroviral therapy for HIV-1 infection and tuberculosisDiane V Havlir
University of California, San Francisco, 995 Potrero Ave, Bldg 80, Ward 84, San Francisco, CA 94110 2897, USA
N Engl J Med 365:1482-91. 2011....
- Decline in the AIDS and death rates in the EuroSIDA study: an observational studyA Mocroft
Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
Lancet 362:22-9. 2003..Since the introduction of highly active antiretroviral therapy (HAART), little is known about whether changes in HIV-1 mortality and morbidity rates have been sustained. We aimed to assess possible changes in these rates across Europe...
- Effect of earlier initiation of antiretroviral treatment and increased treatment coverage on HIV-related mortality in China: a national observational cohort studyFujie Zhang
Division of Treatment and Care, National Centre for AIDS STD Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing, China
Lancet Infect Dis 11:516-24. 2011..Overall HIV mortality rates in China have not been reported. In this analysis we assess overall mortality in treatment-eligible adults with HIV and attempt to identify risk factors for HIV-related mortality...
- Gender differences in survival among adult patients starting antiretroviral therapy in South Africa: a multicentre cohort studyMorna Cornell
Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
PLoS Med 9:e1001304. 2012..Increased mortality among men on antiretroviral therapy (ART) has been documented but remains poorly understood. We examined the magnitude of and risk factors for gender differences in mortality on ART...
- Second-line treatment in the Malawi antiretroviral programme: high early mortality, but good outcomes in survivors, despite extensive drug resistance at baselineM C Hosseinipour
University of North Carolina Project, Lilongwe, Malawi
HIV Med 11:510-8. 2010..Advanced disease progression may occur before switching to second-line ART. We report outcomes for patients evaluated and initiated on second-line treatment in Malawi...
- Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral loadSteven G Deeks
San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
Blood 104:942-7. 2004..These data indicate that immunologic activation set point is established early in HIV infection, and that this set point determines the rate at which CD4+ T cells are lost over time...
- The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settingsCharles F Gilks
Department of HIV AIDS, World Health Organization, Geneva 1211, Switzerland
Lancet 368:505-10. 2006..Simplified operational guidelines, tools, and training materials enable clinical teams in primary-care and second-level facilities to deliver HIV prevention, HIV care, and ART, and to use a standardised patient-tracking system...
- Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studiesMatthias Egger
Department of Social and Preventive Medicine, University of Bern, CH 3012 Bern, Switzerland
Lancet 360:119-29. 2002..The ART Cohort Collaboration, which includes 13 cohort studies from Europe and North America, was established to fill this knowledge gap...
- HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationNicolas Chomont
Laboratoire d Immunologie, Centre de Recherche du Centre Hospitalier de l Université de Montréal Saint Luc, Montreal, Quebec, Canada
Nat Med 15:893-900. 2009....
- Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007Morna Cornell
Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa
AIDS 24:2263-70. 2010..We describe patient outcomes [mortality, loss-to-follow-up (LTFU) and retention] over time in a network of South African ART cohorts...
- Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South AfricaAndrew Boulle
School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Cape Town, South Africa
AIDS 24:563-72. 2010..We report on outcomes after 7 years of a community-based antiretroviral therapy (ART) programme in Khayelitsha, South Africa, with death registry linkages to correct for mortality under-ascertainment...
- Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trialShabbar Jaffar
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
Lancet 374:2080-9. 2009..Identification of new ways to increase access to antiretroviral therapy in Africa is an urgent priority. We assessed whether home-based HIV care was as effective as was facility-based care...
- Maternal or infant antiretroviral drugs to reduce HIV-1 transmissionCharles S Chasela
University of North Carolina Project, Lilongwe, Malawi
N Engl J Med 362:2271-81. 2010..We evaluated the efficacy of a maternal triple-drug antiretroviral regimen or infant nevirapine prophylaxis for 28 weeks during breast-feeding to reduce postnatal transmission of human immunodeficiency virus type 1 (HIV-1) in Malawi...
- T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Infect Dis 187:1534-43. 2003..Interventions that directly target T cell activation or the determinants of activation may prove to be useful adjuvants to antiretroviral therapy...
- CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsWeihong Liu
UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 203:1701-11. 2006..Finally, we show that CD127 can be used to quantitate T reg cell subsets in individuals with type 1 diabetes supporting the use of CD127 as a biomarker for human T reg cells...
- Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countriesPaula Braitstein
Lancet 367:817-24. 2006..We compared baseline characteristics and outcomes during the first year of HAART between HIV-1-infected patients in low-income and high-income settings...
- Four-year treatment outcomes of adult patients enrolled in Mozambique's rapidly expanding antiretroviral therapy programAndrew F Auld
Division of Global AIDS, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 6:e18453. 2011..All ART patients were eligible for co-trimoxazole. ART program outcomes, and determinants of outcomes, have not yet been reported...
- Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from UgandaEdward J Mills
University of Ottawa, Ottawa, Ontario, Canada
Ann Intern Med 155:209-16. 2011..Little is known about the effect of combination antiretroviral therapy (cART) on life expectancy in sub-Saharan Africa...
- Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D studyRainer Weber
Division of Infectious Diseases and Hospital Epidemiology, University Hospital, CH 809a Zurich, Switzerland
Arch Intern Med 166:1632-41. 2006..An increasing proportion of deaths among human immunodeficiency virus (HIV)-infected persons with access to combination antiretroviral therapy (cART) are due to complications of liver diseases...
- Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmissionEllen R Cooper
Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, Boston University School of Medicine, 774 Albany Street, Suite 506, Boston, MA 02118, U S A
J Acquir Immune Defic Syndr 29:484-94. 2002..The Women and Infants Transmission Study is a prospective natural history study that has been enrolling HIV-1-infected pregnant women and their infants since 1989...
- Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis controlStephen D Lawn
Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, South Africa
AIDS 20:1605-12. 2006..To determine burden and risk factors for tuberculosis (TB) in an antiretroviral treatment (ART) programme and its impact on ART outcomes...
- Rapid scaling-up of antiretroviral therapy in 10,000 adults in Côte d'Ivoire: 2-year outcomes and determinantsSiaka Toure
Aconda Association, Abidjan, Cote d Ivoire
AIDS 22:873-82. 2008..To assess the rates and determinants of mortality, loss to follow-up and immunological failure in a nongovernmental organization-implemented program of access to antiretroviral treatment in Côte d'Ivoire...
- Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000-2006Claire L Townsend
MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, London, UK
AIDS 22:973-81. 2008..The aim of this analysis was to explore the impact of different strategies to prevent mother-to-child transmission at a population level...
- Long-term immunologic response to antiretroviral therapy in low-income countries: a collaborative analysis of prospective studiesDenis Nash
Columbia University, Mailman School of Public Health, International Center for AIDS Care and Treatment Programs and Department of Epidemiology, 722 W 168th Street, Room 706, New York, NY 10032 USA
AIDS 22:2291-302. 2008..Few data are available on the long-term immunologic response to antiretroviral therapy (ART) in resource-limited settings, where ART is being rapidly scaled up using a public health approach, with a limited repertoire of drugs...
- Effect of early versus deferred antiretroviral therapy for HIV on survivalMari M Kitahata
University of Washington, Harborview Medical Center, 325 Ninth Ave, Box 359931, Seattle, WA 98104, USA
N Engl J Med 360:1815-26. 2009..The optimal time for the initiation of antiretroviral therapy for asymptomatic patients with human immunodeficiency virus (HIV) infection is uncertain...
- Changes in programmatic outcomes during 7 years of scale-up at a community-based antiretroviral treatment service in South AfricaMweete D Nglazi
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
J Acquir Immune Defic Syndr 56:e1-8. 2011..To assess sustainability of programmatic outcomes in a community-based antiretroviral therapy (ART) service in South Africa during 7 years of scale-up...
- Outcomes of antiretroviral treatment in programmes with and without routine viral load monitoring in Southern AfricaOlivia Keiser
Division of International and Environmental Health, Institute of Social and Preventive Medicine, University of Bern, Switzerland
AIDS 25:1761-9. 2011..To compare outcomes of antiretroviral therapy (ART) in South Africa, where viral load monitoring is routine, with those in Malawi and Zambia, where monitoring is based on CD4 cell counts...
- Projected life expectancy of people with HIV according to timing of diagnosisFumiyo Nakagawa
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, University College London, UK
AIDS 26:335-43. 2012..Our aims were to estimate the life expectancy of an HIV-infected MSM living in a developed country with extensive access to ART and healthcare, and to assess the effect of late diagnosis on life expectancy...
- Time from human immunodeficiency virus seroconversion to reaching CD4+ cell count thresholds <200, <350, and <500 Cells/mm³: assessment of need following changes in treatment guidelinesSara Lodi
MRC Clinical Trials Unit, University College London, UK
Clin Infect Dis 53:817-25. 2011....
- Mortality and loss-to-follow-up during the pre-treatment period in an antiretroviral therapy programme under normal health service conditions in UgandaBarbara Amuron
MRC UVRI Uganda Research Unit on AIDS, Uganda
BMC Public Health 9:290. 2009..The rates of mortality and retention during the pre-treatment period are not well understood. We conducted an observational study to determine these rates...
- The impact of the new WHO antiretroviral treatment guidelines on HIV epidemic dynamics and cost in South AfricaJan A C Hontelez
Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
PLoS ONE 6:e21919. 2011..South Africa decided to adopt this strategy for pregnant and TB co-infected patients only. We estimated the impact of fully adopting the new WHO guidelines on HIV epidemic dynamics and associated costs...
- Immunologic criteria are poor predictors of virologic outcome: implications for HIV treatment monitoring in resource-limited settingsHolly E Rawizza
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Clin Infect Dis 53:1283-90. 2011..In the absence of VL monitoring, switches to second-line ART are based on World Health Organization (WHO) clinical or immunologic failure criteria...
- Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trialP Mugyenyi
MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
Lancet 375:123-31. 2010..This trial investigated whether routine toxicity and efficacy monitoring of HIV-infected patients receiving ART had an important long-term effect on clinical outcomes in Africa...
- Cost-effectiveness of HIV treatment in resource-poor settings--the case of Côte d'IvoireSue J Goldie
Department of Health Policy and Management, Program in Health Decision Science, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 355:1141-53. 2006..As antiretroviral therapy is increasingly used in settings with limited resources, key questions about the timing of treatment and use of diagnostic tests to guide clinical decisions must be addressed...
- Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatmentYves Levy
1INSERM U955, Universite Paris 12, and Assistance Publique Hôpitaux de Paris AP HP, Groupe Henri Mondor Albert Chenevier, Immunologie Clinique, Creteil, France
J Clin Invest 119:997-1007. 2009..Therefore, patients may benefit from intermittent therapy with IL-7 in combination with c-ART...
- Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV diseaseB Autran
Laboratoire d Immunologie Cellulaire, URA CNRS 625, Hopital Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris, France
Science 277:112-6. 1997..Thus, decreasing the HIV load can reverse HIV-driven activation and CD4(+) T cell defects in advanced HIV-infected patients...
- Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in southern AfricaJean B Nachega
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
J Acquir Immune Defic Syndr 51:65-71. 2009..To determine adherence to and effectiveness of antiretroviral therapy (ART) in adolescents vs. adults in southern Africa...
- Effect on transmission of HIV-1 resistance of timing of implementation of viral load monitoring to determine switches from first to second-line antiretroviral regimens in resource-limited settingsAndrew N Phillips
Department of Infection and Population Health, UCL, UK
AIDS 25:843-50. 2011..There is concern that antiretroviral therapy (ART) use with only clinical monitoring for failure will result in high rates of transmission of virus with resistance to drugs currently in use...
- Monitoring of HIV viral loads, CD4 cell counts, and clinical assessments versus clinical monitoring alone for antiretroviral therapy in rural district hospitals in Cameroon (Stratall ANRS 12110/ESTHER): a randomised non-inferiority trialChristian Laurent
Institut de recherche pour le developpement IRD, University Montpellier 1, UMI 233, Montpellier, France
Lancet Infect Dis 11:825-33. 2011..We aimed to assess the effectiveness and safety of clinical monitoring alone (CLIN) in terms of non-inferiority to laboratory and clinical monitoring (LAB)...
- Low retention of HIV-infected patients on antiretroviral therapy in 11 clinical centres in West AfricaDidier K Ekouevi
INSERM, U897, and ISPED, Universite Bordeaux 2, Bordeaux, France
Trop Med Int Health 15:34-42. 2010..To study factors associated with the probability of retention in antiretroviral therapy (ART) programmes in West Africa...
- Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsetsClaude Sportes
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
J Exp Med 205:1701-14. 2008....
- Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directionsElvin H Geng
Division of HIV AIDS at San Francisco General Hospital, 995 Potrero Avenue, San Francisco, CA 94110, USA
Curr HIV/AIDS Rep 7:234-44. 2010..Research to assess and improve retention in care for HIV-infected patients can be strengthened by incorporating novel methods such as sampling-based approaches and a causal analytic framework...
- Age and CD4 count at initiation of antiretroviral therapy in HIV-infected children: effects on long-term T-cell reconstitutionJoanna Lewis
Immunobiology Unit, Institute of Child Health, UK
J Infect Dis 205:548-56. 2012..We describe the effects of children's age and pre-antiretroviral therapy (ART) CD4 count on long-term CD4 T-cell reconstitution...
- Program-level and contextual-level determinants of low-median CD4+ cell count in cohorts of persons initiating ART in eight sub-Saharan African countriesDenis Nash
International Center for AIDS Care and Treatment Programs, Columbia University Mailman School of Public Health, New York, New York, USA
AIDS 25:1523-33. 2011..We examined program-level and contextual-level factors associated with low median CD4 cell count at ART initiation in populations initiating ART...
- CD4 cell count and viral load monitoring in patients undergoing antiretroviral therapy in Uganda: cost effectiveness studyJames G Kahn
Philip R Lee Institute for Health Policy Studies and Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
BMJ 343:d6884. 2011..To examine the cost and cost effectiveness of quarterly CD4 cell count and viral load monitoring among patients taking antiretroviral therapy (ART)...
- Persistent immune activation in HIV-1 infection is associated with progression to AIDSMette D Hazenberg
Department of Clinical Viro Immunology, Sanquin Research at CLB, Tropical Medicine and AIDS, Amsterdam, The Netherlands
AIDS 17:1881-8. 2003..HIV-1 infection is characterized by chronic generalized CD8 and CD4 T cell hyperactivation, the biological effect of which is not understood...
- Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive womenHoward D Strickler
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer 1308, Bronx, NY 10461, USA
J Natl Cancer Inst 97:577-86. 2005....
- The impact of gender and income on survival and retention in a South African antiretroviral therapy programmeMorna Cornell
University of Cape Town, South Africa
Trop Med Int Health 14:722-31. 2009..We investigated the association of gender and income with survival and retention in a South African ART programme...
- Evaluation of the PIMA point-of-care CD4 analyzer in VCT clinics in ZimbabweSekesai Mtapuri-Zinyowera
National Microbiology Reference Laboratory, Harare, Zimbabwe
J Acquir Immune Defic Syndr 55:1-7. 2010..POC CD4 may also alleviate testing burdens at traditional central CD4 laboratories, hence improving test access in both rural and urban environments...
- Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort studyJ Whitworth
Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe
Lancet 356:1051-6. 2000..An association between HIV-1 and malaria is expected in theory, but has not been convincingly shown in practice. We studied the effects of HIV-1 infection and advancing immunosuppression on falciparum parasitaemia and clinical malaria...
- Outcomes after virologic failure of first-line ART in South AfricaRichard A Murphy
Operational Support Unit, Doctors Without Borders, New York, New York 10001, USA
AIDS 24:1007-12. 2010..To determine initial 24-week outcomes among prospectively enrolled patients with failure of initial antiretroviral therapy (ART)...
- Late presentation for human immunodeficiency virus care in the United States and CanadaKeri N Althoff
Johns Hopkins University, Baltimore, Maryland, USA
Clin Infect Dis 50:1512-20. 2010..CONCLUSION. CD4 count at first presentation for HIV care has increased annually over the past 11 years but has remained <350 cells/mm(3), which suggests the urgent need for earlier HIV diagnosis and treatment...
- Vital status of pre-ART and ART patients defaulting from care in rural MalawiMegan McGuire
Medecins Sans Frontieres, Chiradzulu, Malawi
Trop Med Int Health 15:55-62. 2010..To ascertain the outcome of pre-Antiretroviral therapy (ART) and ART patients defaulting from care and investigate reasons for defaulting...
- Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South AfricaJoseph N Jarvis
Department of Medicine, Division of Infectious Diseases, Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa
Clin Infect Dis 48:856-62. 2009..Screening for cryptococcal antigen in patients who enroll in ART programs may identify those at risk of cryptococcal meningitis and permit targeted use of preemptive therapy...
- The public health approach to identify antiretroviral therapy failure: high-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing first-line antiretroviral therapyMina C Hosseinipour
University of North Carolina Project, Lilongwe, Malawi
AIDS 23:1127-34. 2009..We evaluated drug resistance patterns among patients failing first-line ART on the basis of clinical or immunological criteria in Lilongwe and Blantyre, Malawi...
- Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D StudyColette Smith
Research Department of Infection and Population Health, UCL, Royal Free Campus, London, UK
AIDS 24:1537-48. 2010..To investigate any emerging trends in causes of death amongst HIV-positive individuals in the current cART era, and to investigate the factors associated with each specific cause of death...
- Cost-effectiveness of serum cryptococcal antigen screening to prevent deaths among HIV-infected persons with a CD4+ cell count < or = 100 cells/microL who start HIV therapy in resource-limited settingsDavid B Meya
Infectious Disease Institute, Makerere University, Mulago Hospital Complex, Kampala, Uganda
Clin Infect Dis 51:448-55. 2010..We sought to define the cost-effectiveness of serum cryptococcal antigen (CRAG) screening to identify persons with subclinical cryptococcosis and the efficacy of preemptive fluconazole therapy...
- Rapid scale-up of antiretroviral therapy at primary care sites in Zambia: feasibility and early outcomesJeffrey S A Stringer
Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, USA
JAMA 296:782-93. 2006..The Zambian Ministry of Health has scaled-up human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) care and treatment services at primary care clinics in Lusaka, using predominately nonphysician clinicians...
- Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapyGiulia Marchetti
Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
AIDS 22:2035-8. 2008..These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation...
- Isoniazid preventive therapy, HAART and tuberculosis risk in HIV-infected adults in South Africa: a prospective cohortJonathan E Golub
Johns Hopkins University, School of Medicine, 1550 Orleans St, 1M 07 Baltimore, MD 21231, USA
AIDS 23:631-6. 2009..There is less information on the combined effect of IPT and HAART. We assessed the effect of IPT, HAART or both IPT and HAART on tuberculosis incidence in HIV-infected adults in South Africa...
- Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapyPeter W Hunt
Positive Health Program, San Francisco General Hospital, Bldg 80, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
J Infect Dis 197:126-33. 2008....
- Loss to follow-up of adults in public HIV care systems in central Mozambique: identifying obstacles to treatmentMark A Micek
Department of Global Health, University of Washington, Seattle, WA 09195, USA
J Acquir Immune Defic Syndr 52:397-405. 2009..Access to antiretroviral treatment (ART) has expanded dramatically in resource-limited settings. Evaluating loss to follow-up from HIV testing through post-ART care can help identify obstacles to care...
- Initiation of highly active antiretroviral therapy among pregnant women in Cape Town, South AfricaKathryn Stinson
Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa
Trop Med Int Health 15:825-32. 2010..To investigate highly active antiretroviral therapy (HAART) initiation among pregnant women and the optimum model of service delivery for integrating HAART services into antenatal care...
- Sex differences in antiretroviral treatment outcomes among HIV-infected adults in an urban Tanzanian settingClaudia Hawkins
Division of Infectious Diseases, Northwestern University, Chicago, Illinois 60611, USA
AIDS 25:1189-97. 2011..To determine the relationship between sex and antiretroviral therapy (ART) outcomes in an urban Tanzanian setting...
- Implementation of free cotrimoxazole prophylaxis improves clinic retention among antiretroviral therapy-ineligible clients in KenyaPamela K Kohler
Department of Global Health, University of Washington, Seattle, 98104, USA
AIDS 25:1657-61. 2011..To determine whether implementation of free cotrimoxazole (CTX) provision was associated with improved retention among clients ineligible for antiretroviral therapy (ART) enrolled in an HIV treatment program in Kenya...
- Antiretroviral therapy responses among children attending a large public clinic in Soweto, South AfricaTammy M Meyers
Department of Paediatrics, Harriet Shezi Children s Clinic, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Pediatr Infect Dis J 30:974-9. 2011..The aim of this study was to determine treatment responses of children in a routine setting where first-line therapy with lopinavir/ritonavir is routinely included for young children...
- Utility of routine viral load, CD4 cell count, and clinical monitoring among adults with HIV receiving antiretroviral therapy in Uganda: randomised trialJonathan Mermin
Global AIDS Program, Centers for Disease Control and Prevention Uganda, Entebbe, Uganda
BMJ 343:d6792. 2011..To evaluate the use of routine laboratory monitoring in terms of clinical outcomes among patients receiving antiretroviral therapy (ART) in Uganda...
- Performance evaluation of the Pima™ point-of-care CD4 analyser using capillary blood sampling in field tests in South AfricaDeborah K Glencross
Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, 2198, Johannesburg, South Africa
J Int AIDS Soc 15:3. 2012..This study evaluated performance of capillary blood sampling using the point-of-care Pima™ CD4 device in representative primary health care clinics doing HIV testing...
- Tuberculosis incidence rates during 8 years of follow-up of an antiretroviral treatment cohort in South Africa: comparison with rates in the communityAnkur Gupta
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 7:e34156. 2012..We compared these rates with those of HIV-uninfected individuals living in the same community...
- Early antiretroviral therapy improves neurodevelopmental outcomes in infantsBarbara Laughton
Children s Infectious Diseases Clinical Research Unit, Department of Paediatrics and Child Health, Stellenbosch University and Tygerberg Children s Hospital, Cape Town, South Africa
AIDS 26:1685-90. 2012..To evaluate the effect of early versus deferred antiretroviral therapy (ART) on the neurodevelopment of infants from Cape Town participating in the Children with HIV Early Antiretroviral Therapy (CHER) trial...
- Outcomes of antiretroviral therapy in children in Asia and Africa: a comparative analysis of the IeDEA pediatric multiregional collaborationValeriane Leroy
INSERM, U897, Epidemiologie Biostatistiques Bordeaux, France
J Acquir Immune Defic Syndr 62:208-19. 2013..We investigated 18-month incidence and determinants of death and loss to follow-up of children after antiretroviral therapy (ART) initiation in a multiregional collaboration in lower-income countries...
- Decreased sexual risk behavior in the era of HAART among HIV-infected urban and rural South Africans attending primary care clinicsKartik K Venkatesh
Department of Community Health, Brown University, Providence, Rhode Island, USA
AIDS 24:2687-96. 2010..In light of increasing access to HAART in sub-Saharan Africa, we conducted a longitudinal study to assess the impact of HAART on sexual risk behaviors among HIV-infected South Africans in urban and rural primary care clinics...
- Retention in HIV care for individuals not yet eligible for antiretroviral therapy: rural KwaZulu-Natal, South AfricaRichard J Lessells
Africa Centre for Health and Population Studies, University of KwaZulu Natal, Mtubatuba, South Africa
J Acquir Immune Defic Syndr 56:e79-86. 2011..To determine retention in HIV care for individuals not yet eligible for antiretroviral therapy (ART) and to explore factors associated with retention in a rural public health HIV program...
- Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoringOlivia Keiser
Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
AIDS 23:1867-74. 2009..We examined switching from nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line regimens to protease inhibitor-based regimens in Africa, South America and Asia...
- Who starts antiretroviral therapy in Durban, South Africa?... not everyone who shouldIngrid V Bassett
Division of Infectious Disease, Massachusetts General Hospital, Boston, MA 02114, USA
AIDS 24:S37-44. 2010..To evaluate rates of antiretroviral therapy (ART) initiation within 12 months of a new HIV diagnosis in Durban, South Africa...
- Timing of initiation of antiretroviral drugs during tuberculosis therapySalim S Abdool Karim
Centre for the AIDS Programme of Research in South Africa, University of KwaZulu Natal, Durban, South Africa
N Engl J Med 362:697-706. 2010..The optimal timing for the initiation of antiretroviral therapy in relation to tuberculosis therapy remains controversial...
- Antiretroviral therapies in women after single-dose nevirapine exposureShahin Lockman
Brigham and Women s Hospital, Boston, MA, USA
N Engl J Med 363:1499-509. 2010..Peripartum administration of single-dose nevirapine reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus...
- Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonrespondersStefania Piconi
I Divisione Malattie Infettive, H L Sacco, Milan, Italy
Blood 118:3263-72. 2011..HCQ reduces lipopolysaccharide/TLR-mediated immune activation; this compound could be a useful immunomodulant in HIV-infected patients. This study is registered at EutraCT as 2009-012499-28 with study number HLS01/2009-1-16-03-2009...
- Providing immediate CD4 count results at HIV testing improves ART initiationMamsallah Faal
WITS Reproductive Health and HIV Institute, University of the Witwatersrand, Johannesburg, South Africa
J Acquir Immune Defic Syndr 58:e54-9. 2011..We evaluated the impact of a CD4 count result and patient written information provided immediately after diagnosis on retention in care...
- When to start antiretroviral therapy in resource-limited settingsRochelle P Walensky
Massachusetts General Hospital, Brigham and Women s Hospital, Harvard University Medical School, Harvard School of Public Health, and Boston University School of Public Health, Boston, Massachusetts 02114, USA
Ann Intern Med 151:157-66. 2009..The results of international clinical trials that are assessing when to initiate antiretroviral therapy (ART) will not be available for several years...
- Mortality, CD4 cell count decline, and depressive symptoms among HIV-seropositive women: longitudinal analysis from the HIV Epidemiology Research StudyJ R Ickovics
Yale University, Department of Epidemiology and Public Health, PO Box 208034, 60 College St, Suite 415, New Haven, CT 06520 8034, USA
JAMA 285:1466-74. 2001..The impact of depression on morbidity and mortality among women with human immunodeficiency virus (HIV) has not been examined despite the fact that women with HIV have substantially higher rates of depression than their male counterparts...
- Aging and infectious diseases: do patterns of comorbidity vary by HIV status, age, and HIV severity?Joseph L Goulet
Veterans Affairs Connecticut Healthcare System, West Haven, CT 06516, USA
Clin Infect Dis 45:1593-601. 2007..Patterns of comorbidity differ substantially by HIV status, age, and HIV severity. Primary care guidelines require adaptation for persons with HIV infection...
- Early loss of HIV-infected patients on potent antiretroviral therapy programmes in lower-income countriesMartin W G Brinkhof
Institute of Social and Preventive Medicine, Bern, Switzerland
Bull World Health Organ 86:559-67. 2008..To analyse the early loss of patients to antiretroviral therapy (ART) programmes in resource-limited settings...
- Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV-associated atherosclerosisPriscilla Y Hsue
Division of Cardiology, San Francisco General Hospital, San Francisco, California 94110, USA
AIDS 23:1059-67. 2009....
- Human immunodeficiency virus (HIV) type 1 proviral hypermutation correlates with CD4 count in HIV-infected women from KenyaAllison M Land
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
J Virol 82:8172-82. 2008..These findings support the potential of targeting APOBEC3F/G for therapeutic purposes...
- Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South AfricaStephen D Lawn
Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa
AIDS 21:335-41. 2007..To determine the burden and impact of immune reconstitution disease (IRD) associated with tuberculosis (TB) among patients initiating antiretroviral treatment (ART) in sub-Saharan Africa...
- Predictors of long-term viral failure among ugandan children and adults treated with antiretroviral therapyMoses R Kamya
Department of Medicine, Makerere University, Kampala, Uganda
J Acquir Immune Defic Syndr 46:187-93. 2007..We identified predictors of viral failure and documented genotypic mutations in a subset of patients with viral failure after 12 months on antiretroviral therapy (ART)...
- Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatmentColleen F Kelley
Emory University, Atlanta, Georgia, USA
Clin Infect Dis 48:787-94. 2009....
- Long-term outcomes among antiretroviral-naive human immunodeficiency virus-infected patients with small increases in CD4+ cell counts after successful virologic suppressionFernando Dronda
Servicio de Enfermedades Infecciosas, Hospital Ramon y Cajal, Madrid, Spain
Clin Infect Dis 35:1005-9. 2002..PI-containing regimens provided better immunologic response...
- CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppressionRichard D Moore
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Clin Infect Dis 44:441-6. 2007..We characterized the increase in the CD4(+) cell count in patients in clinical practice who maintained sustained viral suppression for up to 6 years...
- Misclassification of first-line antiretroviral treatment failure based on immunological monitoring of HIV infection in resource-limited settingsRami Kantor
Division of Infectious Diseases, Brown University, Providence, Rhode Island, USA
Clin Infect Dis 49:454-62. 2009..The early identification of first-line antiretroviral treatment failure is critical to prevent morbidity, mortality, and drug resistance. Misclassification of failure may result in premature switching to second-line therapy...
- Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort studyMarguerite Guiguet
INSERM U943 and UPMC UMR S 943, Paris, France
Lancet Oncol 10:1152-9. 2009..We examined the effect of these factors on the risk of specific cancers in patients infected with HIV-1...
- Treatment of tuberculosis in HIV-infected persons in the era of highly active antiretroviral therapyGillian L Dean
St Thomas Hospital, London, UK
AIDS 16:75-83. 2002..To assess the risks and benefits of administering highly active antiretroviral therapy (HAART) during the treatment of tuberculosis (TB) in HIV-infected patients...
- Characteristics, determinants, and clinical relevance of CD4 T cell recovery to <500 cells/microL in HIV type 1-infected individuals receiving potent antiretroviral therapyGilbert R Kaufmann
Division of Infectious Diseases and Hospital Epidemiology, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
Clin Infect Dis 41:361-72. 2005..We studied the determinants and the clinical relevance of incomplete CD4 T cell restoration...
- CD4 cell counts of 800 cells/mm3 or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/mm3 or greaterLuuk Gras
HIV Monitoring Foundation, Amsterdam, The Netherlands
J Acquir Immune Defic Syndr 45:183-92. 2007..CD4 cell count changes in therapy-naive patients were investigated during 7 years of highly active antiretroviral therapy (HAART) in an observational cohort...
- Late presenters in the era of highly active antiretroviral therapy: uptake of and responses to antiretroviral therapyCaroline A Sabin
Royal Free and University College Medical School, Royal Free NHS Trust, London, UK
AIDS 18:2145-51. 2004..To investigate the characteristics and clinical, immunological and virological outcomes for individuals presenting for care with low CD4 cell counts...
- EVA MARIA CARMONA PORQUERA; Fiscal Year: 2016....
- Small Animal Model of HIV Neuropathogenesis in the HAART EraPietro P Sanna; Fiscal Year: 2012..Ultimately, the proposed Tg mice will allow mechanistic studies aimed at the generation of new pathogenetic hypotheses of HIV-associated neurocognitive disorders in the setting of HAART and their interaction with drugs of abuse. ..
- Longitudinal Studies of HIV-Associated Bacterial PneumoniaWilliam N Rom; Fiscal Year: 2013..We will freeze and store at -70 degrees plasma, serum, PBMC (RNA, DNA, protein), BAL, from involved/uninvolved lung segments, and sputum for collaborative studies with other NHLBI grantees. ..
- Suppressors of cytokine signaling (SOCS) in HAART-treated HIV infectionMaria C Villacres; Fiscal Year: 2010..As the number of HIV-infected women increase, especially among African-American and Latino minorities, it is highly relevant to understand the reasons for disease progression despite efficient anti-viral treatment. ..
- Alteration of circadian rhythm and sleep by HIV protein TatJian M Ding; Fiscal Year: 2012..EEG analysis showed decreased delta power in the Tat transgenic mice compared to wild type mice. ..
- Non-CD4 Host defense against P. carinii PneumoniaJay K Kolls; Fiscal Year: 2013..3. Test the hypothesis that the combination of anti-Kex1 and anti-carbohydrate antibodies can mediate primary prophylaxis or treatment of PCP in T-cell deficient mice. ..
- CHIRATIDZO ELLEN NDHLOVU; Fiscal Year: 2015..The successful implementation of this screening program through the use of low cost interventions has the potential to decrease incident cryptococcosis in ART treatment programs in sub-Saharan Africa. ..
- Richard E Chaisson; Fiscal Year: 2014....
- JOAN WEINBERGER BERMAN; Fiscal Year: 2015..We will also examine the mechanisms of PrPc release and the consequences of the soluble isoform on neuronal survival, astrocyte function and BBB integrity. ..
- HAART to Prevent HIV Transmission to Infants In BotswanaRoger L Shapiro; Fiscal Year: 2010..The Botswana government has given explicit support for this protocol to occur in four existing Botswana-Harvard AIDS Institute Partnership (BHP) locations to help guide future policy decisions. ..
- Multi-vitamins, HAART and HIV/AIDS in UgandaWafaie W Fawzi; Fiscal Year: 2012..In particular, multivitamins might confer important clinical benefits that would help preserve limited drug regimens in developing countries amidst increasing viral resistant HIV strains. ..
- Oral Transmission of HIV through BreastfeedingLouise Kuhn; Fiscal Year: 2013..These studies will allow an in vivo evaluation of the potential role of anti-HIV innate mucosal immunity that will be informative for potential HIV vaccines that harness mucosal innate immunity. ..
- Marcia McDonnell Holstad; Fiscal Year: 2015..3) Explore: a) the effects of LN on symptoms and symptom management;b) the roles of self-efficacy, outcome expectancies, and personal goal setting as mediators, and depression and health literacy as moderators of adherence. ..
- Jeffrey H Samet; Fiscal Year: 2016..Importantly, if our hypotheses are true, zinc supplementation could ultimately become a standard adjunctive therapy complementing alcohol interventions among HIV+ persons even in resource limited environments. ..
- Immune Response to pneumococcal vaccination in HIV infected adultsM A Westerink; Fiscal Year: 2009..abstract_text> ..
- Nutrition and HIV ProgressionChristine A Wanke; Fiscal Year: 2013..We propose to collect data on 200 women who are documented to be HIV-negative from Voi Division at a single visit, the Division that will also provide the HIV -infected women for the intervention study. ..
- LIPOGENESIS & LIPOPROTEIN COMPLICATIONS OF HIV THERAPYDavid Y Hui; Fiscal Year: 2010..Aim 3 will compare the functionality of the HDL after HAART therapy to determine if these are pro- or anti-atherogenic. ..
- Evaluation of antiretroviral HIV prevention in African HIV discordant couplesJared Baeten; Fiscal Year: 2012..We propose to evaluate user preferences and risk-based targeting of ART-based HIV-1 prevention among HIV-1 serodiscordant couples in Thika, Kenya. ..
- Serologic memory and prevention of Pneumocystis-related COPD in AIDS macaque modeKaren A Norris; Fiscal Year: 2011..abstract_text> ..
- Jay K Kolls; Fiscal Year: 2016..This research will improve the potential development of a vaccine for this infection. ..
- Immune Response to pneumococcal vaccination in HIV infected adultsM A JULIA WESTERINK; Fiscal Year: 2013..More importantly, the results of these studies could clarify controversies in the present vaccine recommendations in the HIV-infected population. ..
- Jeffrey T Parsons; Fiscal Year: 2016....
- Low Cost Laser Diagnostic for CD4+ T Cell CountingMichael J Lochhead; Fiscal Year: 2013..e., productin instruments, clinical trials, regulatory submission, and marketing will be accelerated. ..
- Allison Ross Eckard; Fiscal Year: 2016..Future training in all aspects of clinical research, cardiovascular disease risk assessment, and clinical nutrition is planned to facilitate the PI's development into a successful independent physician scientist. ..
- Analyzing Patient-Provider Communication to Understand Disparities in HIV CareIra B Wilson; Fiscal Year: 2010..A unique feature of this new coding method is that it permits detailed assessment of antiretroviral medication adherence. ..
- JOCELYN CHRISTINE ANDERSON; Fiscal Year: 2015..The findings from the proposed study will be used to inform culturally competent interventions to reduce health disparities among urban, HIV positive women. ..
- Understanding discontinuation of outpatient care among HIV-positive inpatientsLisa R Metsch; Fiscal Year: 2013..g., poverty, housing instability) shape their health practices and health lifestyles. ..
- CD8+ T cell mediated inhibition of HIV-1 replication in Elite SuppressorsJoel N Blankson; Fiscal Year: 2012..This project plans to determine how CD8+ T cells from ES control the virus;the results may be applicable to the development of an effective HIV-1 vaccine. ..
- Clinical Relevance of GB Virus C & Hepatitis C Virus in HIV+ WomenJason T Blackard; Fiscal Year: 2010..Such studies could ultimately lead to novel therapeutic strategies to treat HIV disease, particularly among difficult-to-treat populations and/or individuals with limited access to antiretroviral therapy. ..
- Effects of HIV and ARV Exposure on Child Health and Neurodevelopment in Botswana.Shahin Lockman; Fiscal Year: 2013..We hope to evaluate both of these questions in Botswana in order to improve neurodevelopmental and health outcomes among children born to HIV-infected mothers globally. ..
- MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDRENSherwood Gorbach; Fiscal Year: 2005..This study will also allow us to determine risk factors for persistent diarrhea, and to develop algorithms for the management of infectious diarrhea in a region where HIV infection is common. ..
- MICRONUTRIENTS AND ENTERIC INFECTION IN AFRICAN CHILDRENMICHAEL BENNISH; Fiscal Year: 2002..This study will also allow us to determine risk factors for persistent diarrhea, and to develop algorithms for the management of infectious diarrhea in a region where HIV infection is common. ..
- Mwangelwa Mubiana-Mbewe; Fiscal Year: 2015..To our knowledge, this operations research study will be the + first to look at the impact of POC CD4 testing on clinical outcomes. 2 ..
- A Flow Through Cell Counting AssaySIMON BYSTRYAK; Fiscal Year: 2010..Successful completion of these studies will be beneficial for public health, and make available all of the technology needed for a substantial business opportunity to license the technology and manufacture commercial products. ..
- Diane V Havlir; Fiscal Year: 2016..Outcomes of interest will include cost per: confirmation of meeting ART criteria;ART initiation;virologic suppression;averted death;averted vertical infection;and averted Disability-Adjusted Life Year (DALY). ..
- JUDITH JACQUELINE LOK; Fiscal Year: 2015....
- GWAS on Determinants of HIV-1 Subtype C InfectionMyron E Essex; Fiscal Year: 2010..This study will also quantify the relative contribution of host genetic factors and non-genetic factors to the current epidemic in southern Africa. ..
- DICKSON CHIBANDA; Fiscal Year: 2014..and to estimate the effect of the integrated depression-adherence intervention on antiretroviral adherence, CD4 lymphocyte count, and depression...
- Eric J Arts; Fiscal Year: 2016..We propose that the majority of HIV-1 transmitted from donor to recipient is trapped in the mucosal tissue (e.g. cervix) due to lectin binding and other barriers that effectively "keep pathogens out". ..
- Risk, Severity and Outcome of Bacterial Pneumonia in an HIV +/- Veteran CohortKRISTINA ANNE CROTHERS; Fiscal Year: 2010..These studies can inform patient care and provide a basis for future studies aimed at preventing and improving outcomes from bacterial pneumonia. ..
- Zheng W Chen; Fiscal Year: 2016..III. Determine if HMBPP/IL-2 expansion of V?2V[unreadable]2 T cells can overcome depressed responses of CD4/CD8 T cells and protect against HIV-related TB in SHIV-infected macaques with low CD4 counts. ..
- SIMON BYSTRYAK; Fiscal Year: 2014..Advantages of the proposed technology such as the speed, convenience, and low cost of the analysis substantiates our belief that the FTCA will be widely used in clinical practice. ..
- Cristian L Achim; Fiscal Year: 2015..As these individuals mature, it will be important to understand the implications of neurocognitive impairment on their future behaviors. ..
- Savita Pahwa; Fiscal Year: 2014....
- WORKSHOP ON THE ORAL MANIFESTATIONS OF HIV INFECTIONJohn Greenspan; Fiscal Year: 2000..abstract_text> ..
- Sydney Rosen; Fiscal Year: 2014..Finally, it will help to build the evidence base for "test-and-treat," one of the most innovative ideas currently considered to prevent HIV transmission. ..
- Ann Elizabeth Kurth; Fiscal Year: 2015..Partnership with Kenya's national HIV program will allow lessons learned from this study to inform other countries considering how best to address the growing IDU contribution to the HIV epidemic in this high-HIV-burden region. ..
- Self-Generation of Prospective Memory in HIV-Infected Methamphetamine UsersErica Weber; Fiscal Year: 2013..g., non-adherence) deficits in persons living with HIV infection and addictions. ..
- Ha Youn Lee; Fiscal Year: 2016..The proposed work will advance HIV prevention research by providing a reliable assay based on the characteristics of intrahost HIV diversification. ..
- SECOND INT1 WORKSHOP-ORAL MANIFESTION OF HIV INFECTIONJohn Greenspan; Fiscal Year: 1993....
- Closing the gaps in PMTCT program coverage, early infant diagnosis and treatment.Mary Ann Davies; Fiscal Year: 2013..Using these data, PMTCT program failures will be regularly and systematically analyzed together with Provincial and Local Departments of Health service managers and providers, with a view to achieving iterative service improvements. ..
- Contraception, pregnancy, and HIV-1 risk in African HIV-1 serodiscordant couplesJared Baeten; Fiscal Year: 2012....
- PS05-085, Surv of HIV/AIDS Related Events Among Persons Not Receiving CareBARBARA BOLDEN; Fiscal Year: 2009..abstract_text> ..
- Regulation of APOBEC3G enzymatic activity in HIV-infected primary human T cellsJaisri R Lingappa; Fiscal Year: 2012..The proposed studies should greatly contribute to our knowledge of how A3G/F functions in primary human cells and will add significantly to our incomplete understanding of A3G/F in infected patients. ..
- BRANDON LODGE GUTHRIE; Fiscal Year: 2016....
- HIV-1 Fitness and RecombinationEric J Arts; Fiscal Year: 2012..Based on strong reviewer encouragement from the last funding period, we will continue our modeling studies with our collaborators, Drs. Thomas Leitner and Alan Perelson at Los Alamos National Laboratories (aim 3). ..
- Fungal infections and tolerogenic immunosuppressionFernanda Silveira; Fiscal Year: 2009..Therefore, another major aim of the study is to serially collect serum and urine on consecutive transplant recipients with a view to having a "bank" on which to test new diagnostic methodologies. ..
- MICHAEL DAVID HUGHES; Fiscal Year: 2014..The ultimate goal is to develop practical approaches that can be readily implemented in HIV and co-infection research and, in doing so, help improve programs for the prevention of transmission and the treatment of HIV-infected people. ..
- CHEMOKINES AND HIV REPLICATION IN ALVEOLAR MACROPHAGESMichael Coffey; Fiscal Year: 2000..In summary, this proposal will help determine the mechanisms by which HIV replication is regulated by C-C chemokines in AM, and enhance our understanding of and our ability to control HIV infection in the lung. ..
- Immune Recovery Following LLME Treated Cell TherapyJoanne Filicko; Fiscal Year: 2006..abstract_text> ..
- TUAN DINH LE; Fiscal Year: 2014..abstract_text> ..
- Impact of HIV-1 Fitness on Disease ProgressionEric Arts; Fiscal Year: 2001..Competitions between these env pseudotyped HIV-1 clones will then be compared to competitions between two propagated HIV-1 isolates from the same two patient samples. ..
- HIV Therapy & Interruption RCT in Resource Poor ClinicLuis J Montaner; Fiscal Year: 2010..abstract_text> ..
- HIV Therapy & Interruption RCT in Resource Poor ClinicLuis Montaner; Fiscal Year: 2004..abstract_text> ..
- LPS and Monocyte Activation in HIV NeuropathogenesisDana Gabuzda; Fiscal Year: 2009..The studies will also provide information that could help to identify new potential therapeutic strategies for HIV/AIDS. ..
- A lateral flow CD4 counting assay for resource-poor regionsMichael Lane; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Immunologic Effects of Lactation on HIV infected womenGrace Aldrovandi; Fiscal Year: 2006..Changes in HIV plasma RNA levels over 12 months of breastfeeding will be compared to baseline levels as well as parameters of T cell turnover and thymopoiesis. ..
- ENDODONTIC TREATMENT FOR PERSONS WHO ARE HIV POSITIVEDavid Rosenstein; Fiscal Year: 2001..cellular immunity function will be accurate predictors for endodontic success or failure, and that the CD4 lymphocyte count alone is an inadequate base for making such decisions...
- Genomic and immunological comparisons of M africanum and M tuberculosisBouke C de Jong; Fiscal Year: 2010..The proposed research tries to explain why this bacterium, M. africanum, is more common in HIV infected people, and why a new diagnostic test does not work as well in people with this type of tuberculosis. ..