isotonic solutions

Summary

Summary: Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)

Top Publications

  1. ncbi Randomised controlled trial of intravenous maintenance fluids
    Michael Yung
    Paediatric Intensive Care Unit, Women s and Children s Hospital, South Australia, Australia
    J Paediatr Child Health 45:9-14. 2009
  2. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005
  3. ncbi The effect of intravenous lactated Ringer's solution versus 0.9% sodium chloride solution on serum osmolality in human volunteers
    E L Williams
    Anesthesiology Department, Allegheny University Hospitals, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Anesth Analg 88:999-1003. 1999
  4. ncbi Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 6:CD000567. 2012
  5. ncbi A rational approach to perioperative fluid management
    Daniel Chappell
    Clinic of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    Anesthesiology 109:723-40. 2008
  6. pmc A balanced view of balanced solutions
    Bertrand Guidet
    INSERM, Unité de Recherche en Épidémiologie Systèmes d Information et Modélisation U707, Paris F 75012, France
    Crit Care 14:325. 2010
  7. ncbi Fluid resuscitation: past, present, and the future
    Heena P Santry
    Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Shock 33:229-41. 2010
  8. pmc Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia
    Ronald J Trof
    Department of Intensive Care, Medical Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands
    Intensive Care Med 36:697-701. 2010
  9. ncbi Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame?
    Michael C Madigan
    Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Trauma 64:280-5. 2008
  10. ncbi Crystalloid resuscitation improves survival in trauma patients receiving low ratios of fresh frozen plasma to packed red blood cells
    Nicholas Spoerke
    Division of Trauma and Critical Care, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 71:S380-3. 2011

Detail Information

Publications245 found, 100 shown here

  1. ncbi Randomised controlled trial of intravenous maintenance fluids
    Michael Yung
    Paediatric Intensive Care Unit, Women s and Children s Hospital, South Australia, Australia
    J Paediatr Child Health 45:9-14. 2009
    ..However, this may cause hyponatraemia in sick and post-operative children. We studied the effect of two types of intravenous maintenance fluid and two administration rates on plasma sodium concentration in intensive care patients...
  2. ncbi Comparison of three fluid solutions for resuscitation in dengue shock syndrome
    Bridget A Wills
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 353:877-89. 2005
    ..Although volume replacement is recognized as the critical therapeutic intervention, World Health Organization management guidelines remain empirical rather than evidence-based...
  3. ncbi The effect of intravenous lactated Ringer's solution versus 0.9% sodium chloride solution on serum osmolality in human volunteers
    E L Williams
    Anesthesiology Department, Allegheny University Hospitals, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Anesth Analg 88:999-1003. 1999
    ..001). In healthy humans, an infusion of large volumes of LR, but not NS, transiently decreased serum osmolality, whereas acidosis associated with NS persisted and urinary output was slower with NS...
  4. ncbi Colloids versus crystalloids for fluid resuscitation in critically ill patients
    Pablo Perel
    Cochrane Injuries Group, London School of Hygiene and Tropical Medicine, London, UK
    Cochrane Database Syst Rev 6:CD000567. 2012
    ..Colloid solutions are widely used in fluid resuscitation of critically ill patients. There are several choices of colloid and there is ongoing debate about the relative effectiveness of colloids compared to crystalloid fluids...
  5. ncbi A rational approach to perioperative fluid management
    Daniel Chappell
    Clinic of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    Anesthesiology 109:723-40. 2008
    ..Therefore, undifferentiated fluid handling may increase the shift toward the interstitial space. Using the right kind of fluid in appropriate amounts at the right time might improve patient outcome...
  6. pmc A balanced view of balanced solutions
    Bertrand Guidet
    INSERM, Unité de Recherche en Épidémiologie Systèmes d Information et Modélisation U707, Paris F 75012, France
    Crit Care 14:325. 2010
    ....
  7. ncbi Fluid resuscitation: past, present, and the future
    Heena P Santry
    Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Shock 33:229-41. 2010
    ..Thus, we describe how some novel resuscitation strategies aimed at preventing or ameliorating cellular injury may become clinically available in the future...
  8. pmc Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia
    Ronald J Trof
    Department of Intensive Care, Medical Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands
    Intensive Care Med 36:697-701. 2010
    ..The haemodynamics of crystalloid and colloid fluid loading may depend on underlying disease, i.e. sepsis versus non-sepsis...
  9. ncbi Secondary abdominal compartment syndrome after severe extremity injury: are early, aggressive fluid resuscitation strategies to blame?
    Michael C Madigan
    Department of Surgery, Division of Trauma and Surgical Critical Care, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Trauma 64:280-5. 2008
    ..We hypothesized that poor resuscitation techniques, including early and excessive crystalloid administration, places patients with extremity injuries at risk for developing secondary ACS...
  10. ncbi Crystalloid resuscitation improves survival in trauma patients receiving low ratios of fresh frozen plasma to packed red blood cells
    Nicholas Spoerke
    Division of Trauma and Critical Care, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 71:S380-3. 2011
    ..Our aim was to determine whether the volume of crystalloid given during resuscitation correlated with differences in morbidity or mortality based on the ratio of FFP:PRBC given...
  11. ncbi A comparison of flow rates and warming capabilities of the Level 1 and Rapid Infusion System with various-size intravenous catheters
    Sandra L Barcelona
    Department of Anesthesiology, Northwestern University, The Feinberg School of Medicine, Department of Pediatric Anesthesiology, Children s Memorial Hospital, Chicago, Illinois 60614, USA
    Anesth Analg 97:358-63, table of contents. 2003
    ..e., those used for cases with massive blood loss. The RIS provided no advantage (with regard to heating and flow) when used with typical pediatric-sized catheters...
  12. ncbi Effects on coagulation of balanced (130/0.42) and non-balanced (130/0.4) hydroxyethyl starch or gelatin compared with balanced Ringer's solution: an in vitro study using two different viscoelastic coagulation tests ROTEMTM and SONOCLOTTM
    M Casutt
    Institute of Anesthesiology and Intensive Care, Kantonsspital Lucerne, Lucerne, Switzerland
    Br J Anaesth 105:273-81. 2010
    ..42 solution (HES(BAL)), a saline-based 6% HES 130/0.4 solution (HES(SAL)), a balanced lactated Ringer's solution (RL) and a saline-based 4% gelatin solution (GEL)...
  13. ncbi The inflammatory response to colloids and crystalloids used for pump priming during cardiopulmonary bypass
    E Tamayo
    Department of Anaesthesiology and Reanimation, Valladolid University Hospital, Valladolid, Spain
    Acta Anaesthesiol Scand 52:1204-12. 2008
    ..This study tests the hypothesis that the priming of the extracorporeal circuit with colloid solutions results in less inflammation in patients undergoing cardiac surgery than priming with crystalloid solutions...
  14. ncbi Hydroxyethyl starch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemia
    Johannes N Hoffmann
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Anesthesiology 97:460-70. 2002
    ....
  15. pmc Crystalloids versus colloids for goal-directed fluid therapy in major surgery
    Luzius B Hiltebrand
    Department of Anaesthesiology and Pain Therapy, Inselspital, Bern University Hospital, Freiburgstrasse, Bern, CH 3010, Switzerland
    Crit Care 13:R40. 2009
    ....
  16. pmc The meaning of acid-base abnormalities in the intensive care unit: part III -- effects of fluid administration
    Thomas J Morgan
    Adult Intensive Care, Mater Misericordiae Hospitals, Brisbane, Australia
    Crit Care 9:204-11. 2005
    ..Thus, Stewart's approach not only explains fluid induced acid-base phenomena but also provides a framework for the design of fluids for specific acid-base effects...
  17. ncbi The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies
    Bryan A Cotton
    Department of General Surgery, Vanderbilt University School of Medicine, Nashville, TN 37212, USA
    Shock 26:115-21. 2006
    ..Future resuscitation research is likely to focus on improvements in fluid composition and adjuncts to administration of large volume of fluid...
  18. ncbi Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgery
    Joanne Verheij
    Department of Intensive Care, VU Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Intensive Care Med 32:1030-8. 2006
    ..To study the effects on volume expansion and myocardial function of colloids or crystalloids in the treatment of hypovolaemic hypotension after cardiac and major vascular surgery...
  19. ncbi Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison
    Ole Bayer
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
    Crit Care Med 39:1335-42. 2011
    ..4 and gelatin are considered to be less harmful. We hypothesized that fluid therapy with only crystalloids would decrease the incidence of acute kidney injury...
  20. ncbi The effect of different crystalloid solutions on acid-base balance and early kidney function after kidney transplantation
    Necmiye Hadimioglu
    Department of Anesthesiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey
    Anesth Analg 107:264-9. 2008
    ..This study aimed to quantify changes in acid-base balance, potassium and lactate levels as a function of administration of different crystalloid solutions during kidney transplantation, and to determine the ideal fluid for such patients...
  21. ncbi Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia
    David R McIlroy
    Department of Anesthesiology, University of Washington Medical Center, Seattle, USA
    Anesth Analg 96:1572-7, table of contents. 2003
    ....
  22. ncbi The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study
    P Alvarez Montañana
    Pediatric Intensive Care Unit, Hospital La Fe, Valencia, Spain
    Pediatr Crit Care Med 9:589-97. 2008
    ..We primarily intend to determine whether the use of isotonic fluids prevents hyponatremia and, secondly, whether these fluids increase the incidence of adverse events...
  23. pmc Isotonic is better than hypotonic saline for intravenous rehydration of children with gastroenteritis: a prospective randomised study
    K A Neville
    Department of Endocrinology, Sydney Children s Hospital, Sydney, Australia
    Arch Dis Child 91:226-32. 2006
    ..To determine whether the risk of hyponatraemia in children with gastroenteritis receiving intravenous (IV) fluids is decreased by the use of 0.9% saline...
  24. ncbi Role of pump prime in the etiology and pathogenesis of cardiopulmonary bypass-associated acidosis
    F J Liskaser
    Departments of Anaesthesia and Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Australia
    Anesthesiology 93:1170-3. 2000
    ..Accordingly, acid-base changes induced by the establishment of CPB were studied using two types of priming fluid (Haemaccel, a polygeline solution, and Ringer's Injection vs. Plasmalyte 148) using quantitative biophysical methods...
  25. ncbi Crystalloid strong ion difference determines metabolic acid-base change during in vitro hemodilution
    Thomas J Morgan
    Division of Anesthesiology and Intensive Care, Royal Brisbane Hospital, Queensland, Australia
    Crit Care Med 30:157-60. 2002
    ..To determine the relationship between the strong ion difference (SID) of a diluting crystalloid and its metabolic acid-base effects on in vitro blood dilution...
  26. ncbi Elevation in compartment pressure following hypovolemic shock and fluid resuscitation: a canine model
    Robert H Ablove
    Department of Orthopedics and Rehabilitation, University of Wisconsin Medical School, Madison, USA
    Orthopedics 29:443-5. 2006
    ..While this elevation may not be sufficient enough to cause a compartment syndrome, it reinforces the notion that extremities that have experienced ischemia and reperfusion are at an increased risk for developing compartment syndrome...
  27. ncbi Resuscitation with hydroxyethyl starch solution prevents nuclear factor kappaB activation and oxidative stress after hemorrhagic shock and resuscitation in rats
    Ming Che Tsai
    Department of Emergency Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Shock 27:527-33. 2007
    ..HES solution was an appropriate resuscitation fluid in reversing nuclear factor kappaB activation, maintaining the Bcl-2/Bax ratio, and preventing oxidative stress after acute HS...
  28. ncbi D-lactate increases pulmonary apoptosis by restricting phosphorylation of bad and eNOS in a rat model of hemorrhagic shock
    Amin Jaskille
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Trauma 57:262-69; discussion 269-70. 2004
    ..These modified solutions however alter the function of apoptotic proteins through an unknown mechanism. We postulated that DL-LR induces apoptosis by restricting the phosphorylation of key apoptotic proteins...
  29. ncbi Fluid therapy in uncontrolled hemorrhage--what experimental models have taught us
    R G Hahn
    Anaesthesia and Intensive Care, Linkoping University, Linkoping, Sweden
    Acta Anaesthesiol Scand 57:16-28. 2013
    ..For a hemorrhage of 1000 ml, computer simulations show that deliberate hypovolemia (-300 ml) would be achieved by infusing 600-750 ml crystalloid fluid over 20-30 min or 100 ml of HSD over 10-20 min in an adult male...
  30. ncbi Effects of normal saline vs. lactated ringer's during renal transplantation
    Mohammad Reza Khajavi
    Department of Anesthesiology, Sina Hospital, Medical Sciences University of Tehran, Tehran, Iran
    Ren Fail 30:535-9. 2008
    ..Thus, the aim of this study was to determine the safety of LR if used during a renal transplant...
  31. ncbi Comparisons of lactated Ringer's and Hextend resuscitation on hemodynamics and coagulation following femur injury and severe hemorrhage in pigs
    Wenjun Z Martini
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma Acute Care Surg 74:732-9; discussion 739-40. 2013
    ..This study compared coagulation function after resuscitation with Hextend and lactated Ringer's (LR) solution in pigs with tissue injury and hemorrhagic shock...
  32. ncbi Osmosensitive taurine transporter expression and activity in human corneal epithelial cells
    Ryo Shioda
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, Japan
    Invest Ophthalmol Vis Sci 43:2916-22. 2002
    ..To evaluate whether medium supplementation with taurine improves cell viability during a hypertonic challenge...
  33. ncbi Identification of expression patterns associated with hemorrhage and resuscitation: integrated approach to data analysis
    Huazhen Chen
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    J Trauma 60:701-23; discussion 723-4. 2006
    ....
  34. ncbi Hypertonic saline improves tissue oxygenation and reduces systemic and pulmonary inflammatory response caused by hemorrhagic shock
    Valter Gurfinkel
    Department of Clinical Emergencies, Hospital das Clinicas, University of Sao Paulo, Brazil
    J Trauma 54:1137-45. 2003
    ....
  35. ncbi Effects of different resuscitation fluids on acute lung injury in a rat model of uncontrolled hemorrhagic shock and infection
    Ju Gao
    Department of Anesthesiology, The People s Hospital of Qingyuan, Guangdong, China
    J Trauma 67:1213-9. 2009
    ..To investigate the effects of different resuscitation fluids on acute lung injury in a rat model of uncontrolled hemorrhagic shock (HS) followed by mimicked infection...
  36. ncbi Diluting the benefits of hemostatic resuscitation: a multi-institutional analysis
    Juan Carlos Duchesne
    Section of Trauma and Critical Care Surgery, Department of Surgery, Anesthesia, Emergency Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112 2699, USA
    J Trauma Acute Care Surg 75:76-82. 2013
    ..We hypothesize that HRR patients will have worse outcomes from crystalloid use...
  37. ncbi The history of 0.9% saline
    Sherif Awad
    Division of Gastrointestinal Surgery, Wolfson Digestive Diseases Centre, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Clin Nutr 27:179-88. 2008
    ..We aimed to trace the historical origins of 0.9% saline, how it came to be used so commonly today, and to consider whether its continued use can be justified...
  38. ncbi Crystalloid strong ion difference determines metabolic acid-base change during acute normovolaemic haemodilution
    Thomas J Morgan
    Adult Intensive Care Unit, Mater Misericordiae Hospital, Raymond Terrace, 4101 South Brisbane, Queensland, Australia
    Intensive Care Med 30:1432-7. 2004
    ..To study the acid-base effects of crystalloid strong ion difference (SID) during haemodilution...
  39. ncbi The effects of colloid solutions on renal proximal tubular cells in vitro
    Winfried Neuhaus
    Department of Anaesthesia and Critical Care, University Hospital Wurzburg, Wurzburg, Germany
    Anesth Analg 114:371-4. 2012
    ..HES130/0.4 exhibited the most distinctive harmful impact, whereas the application of crystalloid Sterofundin ISO revealed cytoprotective effects...
  40. pmc Comparison of the effects of gelatin, Ringer's solution and a modern hydroxyl ethyl starch solution after coronary artery bypass graft surgery
    S M Alavi
    Department of Anaesthesiology and Intensive Care Medicine, Rajaei Heart Centre, Tehran University of Medical Sciences, Tehran, Iran
    Cardiovasc J Afr 23:428-31. 2012
    ....
  41. ncbi Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults
    Nor azim Mohd Yunos
    Affiliations Johor Bahru Clinical School, Monash University Sunway Campus, Malaysia
    JAMA 308:1566-72. 2012
    ..Administration of traditional chloride-liberal intravenous fluids may precipitate acute kidney injury (AKI)...
  42. ncbi The effect of HES (130/0.4) usage as the priming solution on renal function in children undergoing cardiac surgery
    Fulya G Akkucuk
    Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    Ren Fail 35:210-5. 2013
    ..Experience with hydroxyethyl starch (HES) in children is limited. This study was conducted to observe the effects of HES or Ringer's lactate (RL) usage as the priming solution on renal functions in children undergoing cardiac surgery...
  43. ncbi Influence of low-molecular-weight hydroxyethyl starch on microvascular permeability in patients undergoing abdominal surgery: comparison with crystalloid
    Yuko Ando
    Department of Anesthesia, Nagasaki Rosai Hospital, 2 12 5 Setogoe, Sasebo, Nagasaki, 857 0134, Japan
    J Anesth 22:391-6. 2008
    ..This study was carried out to evaluate the effect of low-molecular-weight HES on the urinary microalbumin/creatinine ratio (MACR), a marker of microvascular permeability, in surgical patients...
  44. ncbi Clinical benefits after the implementation of a protocol of restricted perioperative intravenous crystalloid fluids in major abdominal operations
    José E de Aguilar-Nascimento
    Department of Surgery, Medical Sciences School, The Federal University of Mato Grosso, Rua Estevao de Mendonca, 81 apto 801, 78043 300, Cuiaba, MT, Brazil
    World J Surg 33:925-30. 2009
    ..The purpose of the present study was to investigate the effect of two different perioperative hydration protocols on the outcome in patients undergoing major abdominal operations...
  45. pmc Hydroxyethyl starch versus Ringer solution in cardiopulmonary bypass prime solutions (a randomized controlled trial)
    Osman Tiryakioglu
    Department of Cardiovascular Surgery, Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey
    J Cardiothorac Surg 3:45. 2008
    ..4 solution, which can be a potential alternative prime solution with an indispensable material for the cardio-pulmonary bypass applications...
  46. ncbi Fluid management for laparoscopic colectomy: a prospective, randomized assessment of goal-directed administration of balanced salt solution or hetastarch coupled with an enhanced recovery program
    A J Senagore
    Spectrum Health, Grand Rapids, Michigan, USA
    Dis Colon Rectum 52:1935-40. 2009
    ....
  47. ncbi Randomized evaluation of fluid resuscitation with crystalloid (saline) and colloid (polymer from degraded gelatin in saline) in pediatric septic shock
    Manasaranjan Upadhyay
    Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian Pediatr 42:223-31. 2005
    ..To compare the efficacy of crystalloid (Normal saline) and colloid (polymer from degraded Gelatin in saline Haemaccel) intravenous fluid in restoration of circulating volume in children with septic shock...
  48. ncbi Colloid vs. crystalloid infusions in gastrointestinal surgery and their different impact on the healing of intestinal anastomoses
    Goran Marjanovic
    Department of Surgery, University of Freiburg, Freiburg, Germany
    Int J Colorectal Dis 25:491-8. 2010
    ..The aim of this study was to investigate if colloid infusions have different effects on intestinal anastomotic healing when compared to crystalloid infusions depending on the amount of the administered volume...
  49. ncbi [Hydroxyethyl starch to protect renal function in laparoscopic surgery]
    J L Jover
    Servicio de Anestesia, Hospital Verge dels Lliris, Alcoy, Alicante
    Rev Esp Anestesiol Reanim 56:27-30. 2009
    ..To evaluate the effect of prehydration with hydroxyethyl starch 130/0.4 (Voluven) compared to lactated Ringer solution in laparoscopic cholecystectomy...
  50. ncbi A comparison of four different techniques of assisted hatching
    Basak Balaban
    Assisted Reproduction Unit, American Hospital of Istanbul, Istanbul, Turkey
    Hum Reprod 17:1239-43. 2002
    ..The aim of the current study was to compare retrospectively the efficacy of AH performed with four different methods in patients undergoing IVF or ICSI...
  51. ncbi Comparison of effects of zona drilling by non-contact infrared laser or acid Tyrode's on the development of human biopsied embryos as revealed by blastomere viability, cytoskeletal analysis and molecular cytogenetics
    Katerina Chatzimeletiou
    The London Bridge Fertility, Gynaecology and Genetics Centre, London SE1 9RY, UK
    Reprod Biomed Online 11:697-710. 2005
    ..Acid Tyrode's drilling can also cause damage, and tended to retard blastocyst development...
  52. pmc Comparison between Ringer's lactate and balanced salt solution on postoperative outcomes after phacoemulsfication: a randomized clinical trial
    Viraj Vasavada
    IOL Research Centre, Raghudeep Eye Clinic, Memnagar, Ahmedabad, India
    Indian J Ophthalmol 57:191-5. 2009
    ..To compare the effects of balanced salt solution (BSS) and Ringer's lactate (RL) on corneal thickness, endothelial morphology, and postoperative anterior chamber inflammation in eyes undergoing phacoemulsification...
  53. ncbi Effect of pump prime on acidosis, strong-ion-difference and unmeasured ions during cardiopulmonary bypass
    F Liskaser
    Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia
    Anaesth Intensive Care 37:767-72. 2009
    ..We suggest future studies examine other possible mechanisms including unmeasured ions...
  54. pmc Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock
    Runkuan Yang
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA 15621, USA
    Mol Med 12:105-14. 2006
    ..These data support the notion that HMGB1 is a mediator of HS/R-induced gut barrier dysfunction and suggest that anti-HMGB1 antibodies warrant further evaluation as a therapeutic to ameliorate the morbidity of HS/R in trauma patients...
  55. doi Inappropriate perioperative fluid management in children: time for an isotonic solution?! Author's reply
    Per Arne Lonnqvist
    Paediatr Anaesth 18:271. 2008
  56. ncbi The impact of crystalloid and colloid infusion on the kidney in rodent sepsis
    Martin Alexander Schick
    Klinik und Poliklinik für Anästhesiologie, Zentrum für Operative Medizin, University of Wurzburg, Oberdürrbacherstrasse 6, 97080 Wurzburg, Germany
    Intensive Care Med 36:541-8. 2010
    ..We therefore determined the impact of crystalloid and colloid solutions on kidney function in a rodent model of abdominal sepsis induced by cecal ligation and puncture (CLP)...
  57. ncbi Prospective study on cardiopulmonary bypass prime reduction and its effect on intraoperative blood product and hemoconcentrator use
    Michael A Sobieski
    Division of Cardiac Surgery, Advocate Christ Medical Center, Oak Lawn, IL, USA
    Perfusion 20:31-7. 2005
    ..Evaluate the feasibility and clinical significance of crystalloid prime reduction during the initiation of cardiopulmonary bypass (CPB) using a modified bridge on the cardioplegia delivery system...
  58. pmc Rubbing salt in the wound
    M Hatherill
    Paediatric Intensive Care Unit, Institute of Child Health, Red Cross Children s Hospital, Klipfontein Road, Cape Town, 7700, South Africa
    Arch Dis Child 89:414-8. 2004
  59. ncbi Acid-base effects of a bicarbonate-balanced priming fluid during cardiopulmonary bypass: comparison with Plasma-Lyte 148. A randomised single-blinded study
    T J Morgan
    Department of Anaesthesia, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Anaesth Intensive Care 36:822-9. 2008
    ..These are likely to be gluconate and/or acetate. Whether surges of exogenous anions during bypass can be harmful requires further study...
  60. ncbi Small increases in extravascular lung water are accurately detected by transpulmonary thermodilution
    Enrique Fernandez-Mondejar
    Hospital Universitario Virgen de las Nieves, Granada, Spain
    J Trauma 59:1420-3; discussion 1424. 2005
    ..Detection of small (10-20%) increases in lung water may be relevant to detect incipient pulmonary edema but no clinically usable method has demonstrated this capability to date...
  61. ncbi Comparison of laser-assisted hatching and acidified Tyrode's hatching by evaluation of blastocyst development rates in sibling embryos: a prospective randomized trial
    Amy E Jones
    Reproductive Biology Associates, Atlanta, Georgia, USA
    Fertil Steril 85:487-91. 2006
    ..To assess two zona drilling methods in terms of blastocyst development rates using sister embryos...
  62. ncbi CONTRA: Hydroxyethyl starch solutions are unsafe in critically ill patients
    Christiane Hartog
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 35:1337-42. 2009
    ..To describe the risk-benefit profile of hydroxyethyl starch (HES)...
  63. ncbi Incidence of postoperative hyponatremia and complications in critically-ill children treated with hypotonic and normotonic solutions
    Alicia K Au
    Department of Pediatrics, Children s National Medical Center, Washington, DC, USA
    J Pediatr 152:33-8. 2008
    ..To determine the incidence and clinical consequences of postoperative hyponatremia in children...
  64. ncbi A randomized, double-blind comparison of lactated Ringer's solution and 0.9% NaCl during renal transplantation
    Catherine M N O'Malley
    Department of Anesthesia, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Anesth Analg 100:1518-24, table of contents. 2005
    ..004). NS did not adversely affect renal function. LR was associated with less hyperkalemia and acidosis compared with NS. LR may be a safe choice for IV fluid therapy in patients undergoing kidney transplantation...
  65. ncbi Early postoperative respiratory acidosis after large intravascular volume infusion of lactated ringer's solution during major spine surgery
    Arzu Takil
    Department of Anesthesiology, Medical Faculty of Marmara University, Istanbul, Turkey
    Anesth Analg 95:294-8, table of contents. 2002
    ..Although intraoperative 20 mL. kg(-1). h(-1) LR infusion does not cause hyperchloremic metabolic acidosis as does NS infusion, it leads to postoperative respiratory acidosis and mild hyponatremia...
  66. ncbi Distribution of normal saline and 5% albumin infusions in septic patients
    D Ernest
    Intensive Care Unit, St Paul s Hospital and University of British Columbia, Vancouver, Canada
    Crit Care Med 27:46-50. 1999
    ..CONCLUSION: Expansion of the ECFV in excess of the volume of 5% albumin infused suggests that fluid may move from the intracellular fluid volume to the ECFV in septic patients who receive this fluid...
  67. ncbi Crystalloid or colloid fluid loading and pulmonary permeability, edema, and injury in septic and nonseptic critically ill patients with hypovolemia
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Crit Care Med 37:1275-81. 2009
    ..We hypothesized that 1) crystalloid loading results in more edema formation than colloid loading and 2) the differences among the types of fluid decreases at high permeability...
  68. ncbi Perioperative fluid management: comparison of high, medium and low fluid volume on tissue oxygen pressure in the small bowel and colon
    L B Hiltebrand
    Washington University, Department of Anesthesiology, St Louis, MO, USA
    Eur J Anaesthesiol 24:927-33. 2007
    ..We tested the hypothesis that high intraoperative fluid volume administration increases intestinal wall tissue oxygen pressure during laparotomy...
  69. ncbi Effect of intraoperative fluid management on outcome after intraabdominal surgery
    Vadim Nisanevich
    Department of Anesthesia and Critical Care Medicine, Hadassah Hebrew University and Medical Center, Jerusalem, Israel
    Anesthesiology 103:25-32. 2005
    ..The debate over the correct perioperative fluid management is unresolved...
  70. ncbi Cold-induced fluid extravasation during cardiopulmonary bypass in piglets can be counteracted by use of iso-oncotic prime
    Marit Farstad
    Department of Anesthesia and Intensive Care, University of Bergen, Haukeland University Hospital, Bergen, Norway
    J Thorac Cardiovasc Surg 130:287-94. 2005
    ..This study aimed to compare whether iso-oncotic priming solutions, in contrast to crystalloids, could reduce the cold-induced fluid extravasation during cardiopulmonary bypass in piglets...
  71. ncbi Comparison of the effects of lactated Ringer solution with and without hydroxyethyl starch fluid resuscitation on gut edema during severe splanchnic ischemia
    S M Lobo
    Serviço de Terapia Intensiva, Departamento de Medicina Interna, Faculdade de Medicina de Rio Preto, Sao Jose do Rio Preto, SP, Brasil
    Braz J Med Biol Res 41:634-9. 2008
    ..9 +/- 1.5) than in the crystalloid-treated group (7.3 +/- 2.4) (P < 0.05). In this model of intestinal ischemia, fluid resuscitation with crystalloids caused more gut edema than a combination of crystalloids and colloids...
  72. pmc Pouring salt on troubled waters
    D Taylor
    Paediatric Intensive Care Unit, Guy s Hospital, London, UK
    Arch Dis Child 89:411-4. 2004
  73. ncbi Prehospital induction of therapeutic hypothermia during CPR: a pilot study
    Antti Kämäräinen
    Medical School, University of Tampere, Tampere, Finland
    Resuscitation 76:360-3. 2008
    ..We studied induction of therapeutic hypothermia during prehospital resuscitation from cardiac arrest using an infusion of ice-cold Ringer's solution in five adult patients...
  74. ncbi Normal saline versus lactated Ringer's solution for intraoperative fluid management in patients undergoing abdominal aortic aneurysm repair: an outcome study
    J H Waters
    Department of General Anesthesiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Anesth Analg 93:817-22. 2001
    ..These changes should be considered when choosing fluids for surgical procedures involving extensive blood loss and requiring extensive fluid administration...
  75. ncbi Effects of lactated Ringer's solutions on human leukocytes
    Elena Koustova
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Trauma 52:872-8. 2002
    ..The aim of this study was to investigate whether racemic LR solution (containing both isomers, dl-LR) differs from LR containing L-isomer only (L-LR)...
  76. ncbi The influence of priming solutions used in cardiopulmonary bypass on blood viscosity in hypothermic conditions
    Sinasi Manduz
    Cumhuriyet University, Cardiovascular Surgery, Sivas, Turkey
    ASAIO J 54:275-7. 2008
    ..Viscosity of all mixtures except RL decreased significantly at deep hypothermia (15 degrees C)...
  77. ncbi Volume replacement with HES 130/0.4 may reduce the inflammatory response in patients undergoing major abdominal surgery
    Katrin Lang
    Departments of Anesthesiology and Intensive Care Medicine, and Clinical Chemistry, Klinikum der Stadt Ludwigshafen, akademisches Lehrkrankenhaus der Universität Mainz, Ludwigshafen, Germany
    Can J Anaesth 50:1009-16. 2003
    ..To investigate the effects of intravascular volume replacement therapy on the inflammatory response during major surgery...
  78. ncbi Acute hospital-induced hyponatremia in children: a physiologic approach
    Malcolm A Holliday
    Department of Pediatrics, University of California, San Francisco, USA
    J Pediatr 145:584-7. 2004
  79. ncbi Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock
    Runkuan Yang
    Department of Critical Care Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Gastrointest Liver Physiol 283:G212-21. 2002
    ..These data support the view that resuscitation with REPS modulates the inflammatory response and decreases hepatocellular and gut mucosal injury in mice subjected to HS/R...
  80. ncbi Conservative vs restrictive individualized goal-directed fluid replacement strategy in major abdominal surgery: A prospective randomized trial
    Emmanuel Futier
    Department of Anesthesiology and Critical Care, University Hospital of Clermont Ferrand, France
    Arch Surg 145:1193-200. 2010
    ....
  81. ncbi A prospective, randomized comparison of thromboelastographic coagulation profile in patients receiving lactated Ringer's solution, 6% hetastarch in a balanced-saline vehicle, or 6% hetastarch in saline during major surgery
    G Martin
    Department of Anesthesiology, and Division of Biometry, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 16:441-6. 2002
    ..To compare the effects of lactated Ringer's solution (LR), 6% hetastarch in a balanced-saline vehicle (HS-BS), and 6% hetastarch in normal saline (HS-NS) on coagulation using thromboelastography...
  82. ncbi Intravenous fluids for seriously ill children
    Malcolm A Holliday
    Lancet 363:241; author reply 242. 2004
  83. ncbi A total balanced volume replacement strategy using a new balanced hydoxyethyl starch preparation (6% HES 130/0.42) in patients undergoing major abdominal surgery
    J Boldt
    Klinikum der Stadt Ludwigshafen, Department of Anaesthesiology and Intensive Care Medicine, Ludwigshafen, Germany
    Eur J Anaesthesiol 24:267-75. 2007
    ....
  84. doi [Study protocol of the VISEP study. Response of the SepNet study group]
    K Reinhart
    Anaesthesist 57:723-8. 2008
    ..However, in our opinion this premature action based on wrong assumptions and containing comments by representatives of pharmaceutical companies does not contribute to a serious, unbiased scientific discourse...
  85. ncbi Assessment of intravascular volume by transthoracic echocardiography during therapeutic hypothermia and rewarming in cardiac arrest survivors
    Johanna Nordmark
    Department of Surgical Sciences Anaesthesiology, Intensive Care, Uppsala University, Sweden
    Resuscitation 80:1234-9. 2009
    ..To study haemodynamic effects and changes in intravascular volume during hypothermia treatment, induced by ice-cold fluids and maintained by ice-packs followed by rewarming in patients after resuscitation from cardiac arrest...
  86. ncbi The risk associated with hyperoncotic colloids in patients with shock
    Frederique Schortgen
    Réanimation Médicale, AP HP, Groupe Hospitalier Albert Chenevier, Henri Mondor, 94000 Creteil, France
    Intensive Care Med 34:2157-68. 2008
    ..This study assessed the risk of renal adverse events in patients with shock resuscitated using hypo-oncotic colloids, artificial hyperoncotic colloids, hyperoncotic albumin or crystalloids, according to physician's choice...
  87. pmc Intravenous postoperative fluid prescriptions for children: a survey of practice
    Polly Davies
    Department of Paediatric Surgery, John Radcliffe Hospital, Oxford, UK
    BMC Surg 8:10. 2008
    ..We aimed to determine the rates and types of intravenous fluids being prescribed postoperatively for children in the UK...
  88. ncbi Circulatory shock in children: an overview
    Christine A McKiernan
    Tufts University School of Medicine, Boston, Mass, USA
    Pediatr Rev 26:451-60. 2005
  89. ncbi Intensive insulin therapy and pentastarch resuscitation in severe sepsis
    Frank M Brunkhorst
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    N Engl J Med 358:125-39. 2008
    ..The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids...
  90. ncbi Preventing neurological complications from dysnatremias in children
    Michael L Moritz
    Division of Nephrology, Department of Pediatrics, Children s Hospital of Pittsburgh, The University of Pittsburgh School of Medicine, PA 15213 2538, USA
    Pediatr Nephrol 20:1687-700. 2005
    ..Breastfed infants must be monitored closely for insufficient lactation and receive lactation support. Judicious use of infant formula supplementation may be called for until problems with lactation can be corrected...
  91. ncbi Fluid management in burn patients: results from a European survey-more questions than answers
    Joachim Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt, Ludwigshafen, Bremserstr 79, D 67063 Ludwigshafen, Germany
    Burns 34:328-38. 2008
    ..New results, e.g. importance of goal-directed therapy or data concerning use of albumin in the critically ill, have not yet influenced strategies of volume replacement in the burn patient...
  92. ncbi Urine sodium composition in ambulatory healthy children: hypotonic or isotonic?
    Michael L Moritz
    Division of Nephrology, Children s Hospital of Pittsburgh, The University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2538, USA
    Pediatr Nephrol 23:955-7. 2008
    ..9+/-0.4 ml/kg per hour. It was concluded that healthy children generate free water via the excretion ofa hypertonic urine. It is unlikely that 0.9% NaCl would result in hypernatremia when administered in parenteral fluids...
  93. ncbi Effects of large volume, ice-cold intravenous fluid infusion on respiratory function in cardiac arrest survivors
    Claudius Jacobshagen
    Department of Cardiology and Pneumology, Georg August University, Gottingen, Germany
    Resuscitation 80:1223-8. 2009
    ..A larger, randomized and prospective study is required to assess the efficacy and safety of ice-cold fluid infusion for the induction of therapeutic hypothermia...
  94. ncbi Hospital-acquired hyponatremia--why are hypotonic parenteral fluids still being used?
    Michael L Moritz
    Division of Nephrology, Children s Hospital of Pittsburgh, Pittsburgh, PA 15217, USA
    Nat Clin Pract Nephrol 3:374-82. 2007
    ....
  95. ncbi Hospital-acquired hyponatremia is associated with excessive administration of intravenous maintenance fluid
    Mark Hatherill
    Pediatrics 114:1368; author reply 1368-9. 2004
  96. ncbi A hyperosmolar-colloidal additive to the CPB-priming solution reduces fluid load and fluid extravasation during tepid CPB
    V Kvalheim
    Section for Cardiothoracic Surgery, Department of Heart Disease, Haukeland University Hospital, N 5021 Bergen, Norway
    Perfusion 23:57-63. 2008
    ..5) and 112 (1.6) mmol/l in Group H. To conclude: addition of 7.2% hypertonic saline and 6% poly (O-2-hydroxyethyl) starch solution to crystalloid CPB prime reduces fluid needs and FER during tepid CPB...
  97. ncbi Fluid resuscitation increases inflammatory gene transcription after traumatic injury
    Jennifer M Watters
    Oregon Health and Science University, Portland, Oregon, USA
    J Trauma 61:300-8; discussion 308-9. 2006
    ..This study aimed to examine effects of resuscitation with lactated Ringer's (LR) and Hextend (HEX) on the inflammatory response after uncontrolled hemorrhagic shock (UHS)...
  98. ncbi [The design of the VISEP trial. Critical appraisal]
    R Zander
    Institut fur Physiologie und Pathophysiologie, Universitat Mainz
    Anaesthesist 56:71-7. 2007
    ..Thus, any further advance presentations and interpretations should be shelved in expectation of the authors' publication of all the data, in order to begin further discussions including the flaws in study design listed here...
  99. ncbi Resuscitation with normal saline (NS) vs. lactated ringers (LR) modulates hypercoagulability and leads to increased blood loss in an uncontrolled hemorrhagic shock swine model
    Laszlo N Kiraly
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Trauma 61:57-64; discussion 64-5. 2006
    ..The purpose of this study was to compare the effects of LR and NS on coagulation in an uncontrolled hemorrhagic swine model. We hypothesized resuscitation with LR would produce hypercoagulability...
  100. pmc Resuscitation of haemorrhagic shock with normal saline vs. lactated Ringer's: effects on oxygenation, extravascular lung water and haemodynamics
    Charles R Phillips
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Physicians Pavilion, Suite 340, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Crit Care 13:R30. 2009
    ..These experiments were designed to determine if differences exist because of crystalloid fluid type in the development of oedema, the impact on oxygenation and the haemodynamic response to fluid administration in early HSR...
  101. ncbi Fluid resuscitation of hypovolemic shock: acute medicine's great triumph for children
    Joseph A Carcillo
    Intensive Care Med 32:958-61. 2006

Research Grants40

  1. Progressive scoliosis deformity in intervertebral disc
    Ian Stokes; Fiscal Year: 2009
    ..These approaches may include improvements in brace design, new possibilities for muscle rehabilitation, and surgical procedures aimed at early, minimally invasive modification of spinal growth. ..
  2. Myocilin-induced ER Stress in Trabecular Meshwork Cells
    SANGLY SRINIVAS; Fiscal Year: 2005
    ..These studies will lead to the development of an essential knowledge base and influence research in the field of glaucoma pathophysiology, diagnostics, and therapeutics. ..
  3. Venous Hemodynamic Function in Older Hypertensive Adults
    WILLIAM FARQUHAR; Fiscal Year: 2006
    ....
  4. AN INTEGRATED MODEL OF INTERVERTEBRAL DISC FUNCTION
    Ian Stokes; Fiscal Year: 2006
    ..and the local conditions that can influence its metabolism, eventual composition and function in three-dimensions. ..
  5. Cytokines in Sickle Cell Volume Regulation
    Alicia Rivera; Fiscal Year: 2006
    ..abstract_text> ..
  6. Oxygen Carriers for Hypovolemic Circulatory Collapse
    Robert Winslow; Fiscal Year: 2007
    ..The research described in this proposal will focus on molecules and formulations specifically tailored for use in prehospital and trauma settings. ..
  7. Sympathetic - Osmotic Interactions in Humans
    WILLIAM FARQUHAR; Fiscal Year: 2007
    ..In some, but not all individuals, dietary salt causes blood pressure to increase. The purpose of this project is to determine why salt increases blood pressures in some individuals. [unreadable] [unreadable] [unreadable]..
  8. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
  9. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
  10. Fluid Movement across Conjunctiva: Stimulation and Regulation
    OSCAR CANDIA; Fiscal Year: 2007
    ..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..
  11. Alcohol Enhances HIV-1 Induced Cardiac Depression
    Kathleen McDonough; Fiscal Year: 2006
    ..The function of the heart will be assessed with the isolated work performing heart and plasma and tissue cytokines and biochemical markers of myocardial oxidative injury and antioxidant capacity will be measured by standard techniques. ..
  12. Mechanism/regulation of human intestinal thiamin uptake
    HAMID SAID; Fiscal Year: 2008
    ..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
  13. Effects of inflammation on developing glia
    Michael Bell; Fiscal Year: 2007
    ..Mentorship in neuroscience as well as the resources of the Mental Retardation and Developmental Disabilities Research Center will support these well-defined training objectives. ..
  14. TRANSMURAL REGULATION Na/K PUMP ACTIVITY IN HEART
    Richard Mathias; Fiscal Year: 2009
    ..The aims of this proposal are to test these two hypotheses. We will use a combination of electrophysiological, Na- and Ca-imaging, contraction, and biochemical measurements to accomplish these aims. ..
  15. Biomimetic Synthesis of an Enamel-Like Material
    Stefan Habelitz; Fiscal Year: 2004
    ..abstract_text> ..
  16. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  17. STABILITY OF MUSCULAR LOADING OF THE LUMBAR SPINE
    Ian Stokes; Fiscal Year: 2002
    ..In addition, the specific roles of individual muscles will be better elucidated, which will be helpful in guiding therapy for people with low back dysfunction. ..
  18. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
    ..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
  19. FUNCTION & REGULATION OF GASTRIC NA/K/2CL COTRANSPORTERS
    Christian Lytle; Fiscal Year: 2002
    ..Completion of these aims will begin to clarify the functional consequences of the migration-associated differentiation of parietal cells. ..
  20. VOLUME REGULATION IN CORNEAL ENDOTHELIUM
    SANGLY SRINIVAS; Fiscal Year: 2002
    ..abstract_text> ..
  21. UNIQUE MECHANISM FOR REABSORPTION OF EDEMA IN THE LUNG
    Richard Effros; Fiscal Year: 2002
    ..The effects of lung injury caused by high vascular pressures, over distention of the lungs, acid aspiration and infections of the oleic acid will be investigated. ..
  22. MECHANICAL MODULATION OF GROWTH IN PHYSES
    Ian Stokes; Fiscal Year: 2003
    ..abstract_text> ..
  23. SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVA
    OSCAR CANDIA; Fiscal Year: 2002
    ..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
  24. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    Margaret Rosenfeld; Fiscal Year: 2004
    ..The results and experience gained by the proposed studies may aid in the rigorous conduct of future clinical trials of inhaled agents in infants both with and without CF. ..
  25. Towards a Non-Invasive Therapy for Atrial Fibrillation
    Benjamin Scherlag; Fiscal Year: 2004
    ..This new therapeutic approach could be utilized as a non-invasive application or incorporated into an implantable device for treatment of patients with PAF. ..
  26. REGULATION OF NA/K PUMP CURRENT IN THE HEART
    Richard Mathias; Fiscal Year: 2004
    ..It will also be used to characterize regulation of pump current in SA node pacemaker cells and determine if regulation of pump current (particularly the alpha2 isoform) affects pacemaking. ..
  27. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2008
    ..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
  28. RHEOLOGICAL DETERMINANTS OF MICROVASCULAR FUNCTION
    HERBERT LIPOWSKY; Fiscal Year: 2009
    ..The results of these studies will provide insight into the role of hemodynamic interactions with the microvessel wall and aid development of therapeutic strategies to treat ischemia and inflammation. ..
  29. Mechanisms of Myocardial Radiofrequency Scar Expansion
    Rupak Mukherjee; Fiscal Year: 2004
    ..abstract_text> ..
  30. Measurement of Fluid Flow Across the Ocular Ciliary Body
    OSCAR CANDIA; Fiscal Year: 2006
    ..abstract_text> ..
  31. C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    HAMID SAID; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  32. Inhaled Large Porous Particles for Treatment of MDR-TB
    David Edwards; Fiscal Year: 2006
    ..It represents a new paradigm for treating and limiting the spread (especially nosocomial transmission) of respiratory infectious diseases such as TB, severe acute respiratory syndrome (SARS), influenza, and small pox. ..
  33. CHANNEL-MEDIATED RBC DEHYDRATION IN SICKLE CELL DISEASE
    Alicia Rivera; Fiscal Year: 2003
    ..It is additionally significant, because it will provide the means for the applicant to establish an independent research career and to become competitive for a tenure-track assistant professional position. ..
  34. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
    ..abstract_text> ..
  35. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..