methylcellulose

Summary

Summary: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.

Top Publications

  1. ncbi A novel system for three-pulse drug release based on "tablets in capsule" device
    Bin Li
    Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210038, PR China
    Int J Pharm 352:159-64. 2008
  2. ncbi Zero-order release of aspirin, theophylline and atenolol in water from novel methylcellulose glutarate matrix tablets
    A Khairuzzaman
    Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, University Plaza, Brooklyn, NY 11201, USA
    Int J Pharm 318:15-21. 2006
  3. pmc Management of irritable bowel syndrome in primary care: feasibility randomised controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website. (MIBS trial)
    Hazel A Everitt
    Primary Medical Care, School of Medicine, University of Southampton, Southampton SO17 1BJ, UK
    BMC Gastroenterol 10:136. 2010
  4. pmc In vitro release kinetics and bioavailability of gastroretentive cinnarizine hydrochloride tablet
    Ramesh C Nagarwal
    Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India
    AAPS PharmSciTech 11:294-303. 2010
  5. ncbi Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact lenses
    Charles J White
    Biomimetic and Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Chemical Engineering, 212 Ross Hall, Auburn University, AL 36849, United States
    Biomaterials 32:5698-705. 2011
  6. ncbi Enhanced oral bioavailability of a poorly water soluble drug PNU-91325 by supersaturatable formulations
    Ping Gao
    Worldwide Pharmaceutical Sciences, Pfizer Inc, Kalamazoo, Michigan 49007, USA
    Drug Dev Ind Pharm 30:221-9. 2004
  7. ncbi Trypanosoma brucei gambiense: HMI-9 medium containing methylcellulose and human serum supports the continuous axenic in vitro propagation of the bloodstream form
    N Van Reet
    Institute of Tropical Medicine, Department of Parasitology, Nationalestraat 155, 2000 Antwerp, Belgium
    Exp Parasitol 128:285-90. 2011
  8. ncbi Swelling, erosion and drug release characteristics of salbutamol sulfate from hydroxypropyl methylcellulose-based matrix tablets
    Faith A Chaibva
    Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa
    Drug Dev Ind Pharm 36:1497-510. 2010
  9. ncbi Critical evaluation of methylcellulose as an alternative medium in sperm migration tests
    Ana Ivic
    The Assisted Conception Unit, Birmingham Women s Hospital, Birmingham B15 2TG, UK
    Hum Reprod 17:143-9. 2002
  10. ncbi Engineering cartilage with human nasal chondrocytes and a silanized hydroxypropyl methylcellulose hydrogel
    C Vinatier
    INSERM U 791, Laboratory of Osteoarticular and Dental Tissue Engineering, LIOAD, University of Nantes, France
    J Biomed Mater Res A 80:66-74. 2007

Detail Information

Publications282 found, 100 shown here

  1. ncbi A novel system for three-pulse drug release based on "tablets in capsule" device
    Bin Li
    Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210038, PR China
    Int J Pharm 352:159-64. 2008
    ..However, lactose favored it. The results reveal that programmed drug delivery to achieve pulsatile drug release for three times daily can be obtained from these tablets in capsule system by systemic formulation approach...
  2. ncbi Zero-order release of aspirin, theophylline and atenolol in water from novel methylcellulose glutarate matrix tablets
    A Khairuzzaman
    Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, University Plaza, Brooklyn, NY 11201, USA
    Int J Pharm 318:15-21. 2006
    A novel hydrocolloidal polymer, methylcellulose glutarate (MC-GA), was prepared by esterifying methylcellulose with glutaric anhydride. The formation of ester was confirmed by FTIR and NMR spectroscopy, DSC and elemental analysis...
  3. pmc Management of irritable bowel syndrome in primary care: feasibility randomised controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website. (MIBS trial)
    Hazel A Everitt
    Primary Medical Care, School of Medicine, University of Southampton, Southampton SO17 1BJ, UK
    BMC Gastroenterol 10:136. 2010
    ..We have developed a web-based CBT self-management programme, Regul8, based on an existing evidence based self-management manual and in partnership with patients. This could increase access with minimal increased costs...
  4. pmc In vitro release kinetics and bioavailability of gastroretentive cinnarizine hydrochloride tablet
    Ramesh C Nagarwal
    Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India
    AAPS PharmSciTech 11:294-303. 2010
    ..release of CNZ from different floating matrix formulations containing four viscosity grades of hydroxypropyl methylcellulose, sodium alginate or polyethylene oxide, and gas-forming agent (sodium bicarbonate or calcium carbonate) was ..
  5. ncbi Extended release of high molecular weight hydroxypropyl methylcellulose from molecularly imprinted, extended wear silicone hydrogel contact lenses
    Charles J White
    Biomimetic and Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Chemical Engineering, 212 Ross Hall, Auburn University, AL 36849, United States
    Biomaterials 32:5698-705. 2011
    ..an extended wear silicone hydrogel contact lens with extended, controllable release of 120 kDa hydroxypropyl methylcellulose (HPMC) using a molecular imprinting strategy...
  6. ncbi Enhanced oral bioavailability of a poorly water soluble drug PNU-91325 by supersaturatable formulations
    Ping Gao
    Worldwide Pharmaceutical Sciences, Pfizer Inc, Kalamazoo, Michigan 49007, USA
    Drug Dev Ind Pharm 30:221-9. 2004
    ..systems (S-SEDDS) are designed to incorporate water soluble cellulosic polymers such as hydroxypropyl methylcellulose (HPMC), which may inhibit or retard drug precipitation in vivo...
  7. ncbi Trypanosoma brucei gambiense: HMI-9 medium containing methylcellulose and human serum supports the continuous axenic in vitro propagation of the bloodstream form
    N Van Reet
    Institute of Tropical Medicine, Department of Parasitology, Nationalestraat 155, 2000 Antwerp, Belgium
    Exp Parasitol 128:285-90. 2011
    ..b. brucei strains, based on methylcellulose containing HMI-9 medium, also facilitated the continuous in vitro propagation of other bloodstream form ..
  8. ncbi Swelling, erosion and drug release characteristics of salbutamol sulfate from hydroxypropyl methylcellulose-based matrix tablets
    Faith A Chaibva
    Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa
    Drug Dev Ind Pharm 36:1497-510. 2010
    ..Hydrophilic matrix formulations are important and simple technologies that are used to manufacture sustained release dosage forms...
  9. ncbi Critical evaluation of methylcellulose as an alternative medium in sperm migration tests
    Ana Ivic
    The Assisted Conception Unit, Birmingham Women s Hospital, Birmingham B15 2TG, UK
    Hum Reprod 17:143-9. 2002
    The aim of this study was to evaluate the ability of human spermatozoa to penetrate methylcellulose (MC) and to compare this with penetration in hyaluronic acid.
  10. ncbi Engineering cartilage with human nasal chondrocytes and a silanized hydroxypropyl methylcellulose hydrogel
    C Vinatier
    INSERM U 791, Laboratory of Osteoarticular and Dental Tissue Engineering, LIOAD, University of Nantes, France
    J Biomed Mater Res A 80:66-74. 2007
    ..In this study, the authors aimed at determining whether a recently developed silanized hydroxypropyl methylcellulose (Si-HPMC) hydrogel can be a suitable scaffold for human nasal chondrocytes (HNC)-based cartilage engineering...
  11. ncbi Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord
    Dimpy Gupta
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ont, Canada
    Biomaterials 27:2370-9. 2006
    ..A gel that meets these design criteria is a blend of hyaluronan and methylcellulose (HAMC). Unlike other injectable gels, HAMC is already at the gelation point prior to injection...
  12. pmc Rheological characterization of the bundling transition in F-actin solutions induced by methylcellulose
    Simone Köhler
    Lehrstuhl für Biophysik E27, Technische Universitat Munchen, Garching, Germany
    PLoS ONE 3:e2736. 2008
    ..Therefore, additives are widely used to increase the solvent viscosity. For this purpose, methylcellulose (MC) has been proven highly effective as already small concentrations can significantly slow down diffusive ..
  13. ncbi In-vitro and in-vivo erosion profiles of hydroxypropylmethylcellulose (HPMC) matrix tablets
    Manish Ghimire
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0NR, UK
    J Control Release 147:70-5. 2010
    ..The study demonstrated that a matrix formulation with a lower concentration of HPMC and higher lactose concentration is more likely to perform poorly in the in-vivo environment...
  14. ncbi Formulation and evaluation of a gastroretentive dosage form of labetalol hydrochloride
    Harshal Garse
    Bharati Vidyapeeth s College of Pharmacy, University of Mumbai, Sector 8, CBD Belapur, Navi Mumbai, 400614, Maharashtra, India
    Arch Pharm Res 33:405-10. 2010
    ..Formulation was optimized using Stat-Ease Design Expert 7.1 software. Optimized batch was evaluated for the effect of change of osmolarity and pH on drug release, floating and swelling behaviour...
  15. ncbi Differentiation of HPV-containing cells using organotypic "raft" culture or methylcellulose
    Regina Wilson
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Methods Mol Med 119:157-69. 2005
    ..Differentiation in organotypic raft cultures as well as upon suspension in semi-solid media have been used to study both early and late stages of the viral life cycle...
  16. ncbi Comprehensive investigation of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-beta-cyclodextrin for use in general toxicology studies
    EVAN A THACKABERRY
    Merck Research Laboratories, Department of Safety Assessment, Lafayette, New Jersey 07848, USA
    Toxicol Sci 117:485-92. 2010
    ..Twenty (20) mg/kg of hydroxypropyl methylcellulose (MC, control), 10 mg/kg PS80, 1000 mg/kg PG, 500 mg/kg HPβCD, or 1000 mg/kg HPβCD were administered by oral ..
  17. ncbi Affinity-based release of chondroitinase ABC from a modified methylcellulose hydrogel
    Malgosia M Pakulska
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON M5S 1A1, Canada
    J Control Release 171:11-6. 2013
    ..The release of active ChABC-SH3 was sustained from a methylcellulose hydrogel covalently modified with an SH3 binding peptide...
  18. ncbi Bioavailability and in vitro oesophageal sticking tendency of hydroxypropyl methylcellulose capsule formulations and corresponding gelatine capsule formulations
    Outi Honkanen
    Department of Pharmacy, University of Helsinki, P O Box 56, Finland
    Eur J Pharm Sci 15:479-88. 2002
    ..of the present study was to widen our knowledge about the biopharmaceutical behaviour of novel hydroxypropyl methylcellulose (HPMC)-based two-piece capsules by comparing them with the classic hard gelatine capsules...
  19. ncbi Influence of hydroxypropyl methylcellulose polymer on in vitro and in vivo performance of controlled release tablets containing alprazolam
    Vorapann Mahaguna
    College of Pharmacy, Austin, TX, USA
    Eur J Pharm Biopharm 56:461-8. 2003
    The purpose of this study was to investigate the influence of hydroxypropyl methylcellulose (HPMC) molecular weight on pharmacokinetic and pharmacodynamic parameters of controlled release formulations containing alprazolam...
  20. ncbi Curative and preventive activity of hydroxypropyl methylcellulose-lipid edible composite coatings containing antifungal food additives to control citrus postharvest green and blue molds
    Silvia A Valencia-Chamorro
    Centro de Tecnologia Poscosecha, Instituto Valenciano de Investigaciones Agrarias, 46113 Moncada, Valencia, Spain
    J Agric Food Chem 57:2770-7. 2009
    Edible composite coatings based on hydroxypropyl methylcellulose (HPMC), lipid components (beeswax and shellac), and food preservatives with antifungal properties were evaluated in vivo on clementine mandarins cv...
  21. ncbi Development of photocrosslinked methylcellulose hydrogels for soft tissue reconstruction
    Simone S Stalling
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    Acta Biomater 5:1911-8. 2009
    A variety of materials have been used as fillers for soft tissue augmentation. In this study, methylcellulose (MC), a water-soluble derivative of the polysaccharide cellulose, was modified with functional methacrylate groups and ..
  22. ncbi Efficacy of methylcellulose and loperamide in managing fecal incontinence
    Eddie H M Sze
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Urogynecology and Reconstructive Pelvic Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Acta Obstet Gynecol Scand 88:766-71. 2009
    To evaluate the efficacy of methylcellulose (Citrucel) and loperamide (Imodium) in managing fecal incontinence by comparing cure rates with expectant management.
  23. ncbi Preparation and in vitro evaluation of sustained release tablet formulations of diclofenac sodium
    Ayhan Savaser
    Department of Pharmaceutical Technology, Gulhane Military Medical Academy, Etlik, 06018 Ankara, Turkey
    Farmaco 60:171-7. 2005
    ..This formulation also exhibited the best-fitted formulation into the zero order kinetics. The precision and accuracy of the analytical method were also checked. The repeatability and reproducibility of the method were also determined...
  24. ncbi Accelerated release of a sparingly soluble drug from an injectable hyaluronan-methylcellulose hydrogel
    Yuanfei Wang
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, Canada M5S 3E5
    J Control Release 140:218-23. 2009
    An injectable hydrogel, comprised of hyaluronan and methylcellulose (HAMC), shows promise for localized, sustained delivery of growth factors for treatment of spinal cord injury (SCI)...
  25. ncbi Scratch resistance of plasticized hydroxypropyl methylcellulose (HPMC) films intended for tablet coatings
    Kalle Hanhijärvi
    Department of Physics, University of Helsinki, Helsinki, Finland
    Eur J Pharm Biopharm 74:371-6. 2010
    Scratch resistance (SR) of externally plasticized hydroxypropyl methylcellulose (HPMC) films intended for tablet film coatings was studied...
  26. pmc Evaluation of methylcellulose and dimethyl sulfoxide as the cryoprotectants in a serum-free freezing media for cryopreservation of adipose-derived adult stem cells
    Sreedhar Thirumala
    Bioengineering Laboratory, Department of Mechanical Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Stem Cells Dev 19:513-22. 2010
    ..Our results suggest that post-thaw ASC viability, adipogenic and osteogenic differentiability can be maintained even when they are frozen in the absence of serum but with a minimal concentration of 2% DMSO in DMEM...
  27. ncbi Release characteristics and in vitro-in vivo correlation of pulsatile pattern for a pulsatile drug delivery system activated by membrane rupture via osmotic pressure and swelling
    Hong Liang Lin
    College of Pharmacy, Taipei Medical University, Taiwan, ROC
    Eur J Pharm Biopharm 70:289-301. 2008
    ..2 solution and the in vivo release rate was better reflected by that performed in pH 6.8 buffer...
  28. ncbi Assembled modules technology for site-specific prolonged delivery of norfloxacin
    Paulo Renato Oliveira
    Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Quality Control Laboratory, J K 207, 88040 900 Florianopolis SC, Brazil
    Int J Pharm 405:90-6. 2011
    ..The assembled systems were able to float in vitro for up to 240min, indicating that this drug delivery system of norfloxacin could provide gastro-retentive site-specific release for increasing norfloxacin bioavailability...
  29. ncbi An injectable bone substitute composed of beta-tricalcium phosphate granules, methylcellulose and hyaluronic acid inhibits connective tissue influx into its implantation bed in vivo
    S Ghanaati
    Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Acta Biomater 7:4018-28. 2011
    ..triphasic and injectable paste-like bone-substitute material composed of beta-tricalcium phosphate (β-TCP), methylcellulose and hyaluronic acid was analyzed...
  30. ncbi Sterilized ophthalmic hydrogels with hydroxypropyl methylcellulose: determination and mathematical treatment of flow properties
    Zdenek Zatloukal
    Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy, Hradec Kralove, Czech Republic
    Pharm Dev Technol 12:55-60. 2007
    ..the influence of electrolytes on the viscosity of sterilized hydrogels containing 60 g/L of hydroxypropyl methylcellulose (HPMC 4000) was investigated...
  31. ncbi Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model
    Noriaki Nagai
    Faculty of Pharmacy, Kinki University, Osaka, Japan
    Biol Pharm Bull 35:239-45. 2012
    We attempted to develop anti-cataract eye drops using disulfiram (DSF) and low-substituted methylcellulose (MC), and evaluated their anti-cataract effect in terms of the lens opacification vs...
  32. ncbi Methylcellulose as a rectal contrast agent for MR imaging of rectal carcinoma
    Jeffrey Seow Kuang Goh
    Department of Diagnostic Radiology, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433
    AJR Am J Roentgenol 178:1145-6. 2002
  33. ncbi Matrices containing NaCMC and HPMC 2. Swelling and release mechanism study
    S Conti
    Department of Pharmaceutical Chemistry, Via Taramelli, 12, I 27100 Pavia, Italy
    Int J Pharm 333:143-51. 2007
    ..In these buffers, MB systems maintain a constant drug release rate coupling diffusion and erosion mechanism: the gel and infiltrated layers thicknesses are maintained constant and a zero-order release kinetics can be achieved...
  34. pmc Use of a commercial methylcellulose medium with and without recombinant bovine granulocyte colony-stimulating factor for culturing bovine bone marrow cells
    Sonya L Keller
    Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1
    Can J Vet Res 68:157-9. 2004
    A commercial methylcellulose culture medium, with and without the addition of recombinant bovine granulocyte colony-stimulating factor (rbG-CSF), was utilized for culturing bovine bone marrow cells in a colony-forming unit assay...
  35. ncbi Effects of miglyol 812 on rats after 4 weeks of gavage as compared with methylcellulose/tween 80
    Rani S Sellers
    Non Clinical Development Safety, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Drug Chem Toxicol 28:423-32. 2005
    ..5% methylcellulose/0...
  36. ncbi Synthesis and general properties of silated-hydroxypropyl methylcellulose in prospect of biomedical use
    Xavier Bourges
    INSERM E 99 03, Laboratoire des Tissus Calcifiés, Faculte de Chirurgie Dentaire, 1 Place Alexis Ricordeau, 44042 Nantes, France
    Adv Colloid Interface Sci 99:215-28. 2002
    ..e. pH, silane percentage and temperature. Minimum kinetic of the condensation was observed for pH between 5.5 and 6.5. So temperature catalyzed the reaction and the self-hardening speed was increased by silane percentage...
  37. ncbi Sustained release of acetaminophen from a heterogeneous mixture of two hydrophilic non-ionic cellulose ether polymers
    Nkere K Ebube
    Wyeth Consumer Healthcare, 1211 Sherwood Avenue, Richmond, VA 23261, USA
    Int J Pharm 272:19-27. 2004
    This study examined the release of acetaminophen (APAP) from hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC) matrices...
  38. ncbi Analysis and modeling of swelling and erosion behavior for pure HPMC tablet
    Serafina Chirico
    Department of Chemical and Food Engineering, University of Salerno, Fisciano SA, Italy
    J Control Release 122:181-8. 2007
    ..Even if the model was already used in literature, the novelty of our approach is to compare model predictions with a complete set of experimental data, confirming that the main phenomena were correctly identified and described...
  39. ncbi Correlation between the permeability of metoprolol tartrate through plasticized isolated ethylcellulose/hydroxypropyl methylcellulose films and drug release from reservoir pellets
    Zhi Wei Ye
    Laboratorium voor Farmacotechnologie en Biofarmacie, Katholieke Universiteit Leuven, Leuven, Belgium
    Eur J Pharm Biopharm 67:485-90. 2007
    ..The present study investigates if drug diffusion through plasticized isolated ethylcellulose (EC)/hydroxypropyl methylcellulose (HPMC) films prepared by solvent casting can be used as a tool to develop spray-coated dosage forms...
  40. ncbi Study of the critical points of HPMC hydrophilic matrices for controlled drug delivery
    Antonia Miranda
    Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain
    Int J Pharm 311:75-81. 2006
    ....
  41. pmc Fabrication of modified release tablet formulation of metoprolol succinate using hydroxypropyl methylcellulose and xanthan gum
    Mukesh C Gohel
    Department of Pharmaceutics and Pharmaceutical Technology, L M College of Pharmacy, Navrangpura, Ahmedabad, Gujarat, India
    AAPS PharmSciTech 10:62-8. 2009
    ..investigation was undertaken to fabricate modified release tablet of metoprolol succinate using hydroxypropyl methylcellulose (HPMC) and xanthan gum as a matrixing agent...
  42. ncbi Validation of macroscopic attenuated total reflection-Fourier transform infrared imaging to study dissolution of swelling pharmaceutical tablets
    Jaap van der Weerd
    Department of Chemical Engineering and Chemical Technology, Imperial College London, SW7 2AZ, United Kingdom
    Appl Spectrosc 58:1413-9. 2004
    ..reflection (ATR) infrared imaging is applied to study the dissolution of realistically sized hydroxypropyl methylcellulose (HPMC) tablets...
  43. ncbi Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters
    Glenn E Bartley
    Processed Foods Research, Western Regional Research Center, USDA, Agricultural Research Service, Albany, CA 94710, USA
    J Nutr 140:1255-60. 2010
    Hydroxypropyl methylcellulose (HPMC), a semisynthetic, nonfermentable soluble dietary fiber, is not absorbed by the body, but its presence in the intestinal lumen increases fecal fat, sterol, and bile acid excretions and decreases ..
  44. ncbi Spatially resolved solvent interaction with glassy HPMC polymers studied by magnetic resonance microscopy
    Jadwiga Tritt-Goc
    Institute of Molecular Physics, Polish Academy of Sciences, M Smoluchowskiego 17, 60 179 Poznan, Poland
    Solid State Nucl Magn Reson 28:250-7. 2005
    ..The influence of the molecular mass of the HPMC polymers on swelling properties has been shown...
  45. pmc Magnetic resonance imaging and image analysis for assessment of HPMC matrix tablets structural evolution in USP Apparatus 4
    Piotr Kulinowski
    Department of Magnetic Resonance Imaging, Institute of Nuclear Physics, Polish Academy of Sciences, ul Radzikowskiego 152, 31 342 Krakow, Poland
    Pharm Res 28:1065-73. 2011
    ..The results of the study were verified by comparison with other approaches presented in literature...
  46. pmc Variations in rigidity and ligand density influence neuronal response in methylcellulose-laminin hydrogels
    SARAH E STABENFELDT
    Petit Institute for Bioengineering and Bioscience, Laboratory for Neuroengineering, W H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, USA
    Acta Biomater 7:4102-8. 2011
    ..To this end, we developed and characterized a tunable 3-D methylcellulose (MC) hydrogel polymeric system tethered to laminin-1 (MC-x-LN) across a range of substrate rigidities (G* ..
  47. ncbi Observation of swelling process and diffusion front position during swelling in hydroxypropyl methyl cellulose (HPMC) matrices containing a soluble drug
    P Colombo
    Department of Pharmacy, University of Parma, 43100, Parma, Italy
    J Control Release 61:83-91. 1999
    ..The physical analysis of such systems clearly showed the importance of drug solubility and loading in the observation of the diffusion front...
  48. ncbi Detection of organophosphorus pesticides using potentiometric enzymatic membrane biosensor based on methylcellulose immobilization
    Jinzhong Zhang
    College of Resources and Environment, Southwest University, Chongqing 400716, PR China
    Anal Sci 25:511-5. 2009
    ..was a pH electrode modified with an immobilized acetylcholinesterase layer formed by entrapment with methylcellulose, N,N-dimethylformamide, and bovine serum albumin...
  49. ncbi Study of the critical points of experimental HPMC-NaCMC hydrophilic matrices
    L Contreras
    Department of Pharmacy and Pharmaceutical Technology, University of Seville, 41012 Seville, Spain
    Int J Pharm 386:52-60. 2010
    ..The knowledge of this critical barrier will be useful in order to optimize the design of the ternary hydrophilic matrix systems...
  50. ncbi Agarose and methylcellulose hydrogel blends for nerve regeneration applications
    Benton C Martin
    Regeneration and Repair Laboratory, Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931 1295, USA
    J Neural Eng 5:221-31. 2008
    ..Our studies have shown that thermoreversible methylcellulose can be combined with agarose to create hydrogel blends that accommodate these properties...
  51. ncbi Magnetic resonance imaging and X-ray microtomography studies of a gel-forming tablet formulation
    P R Laity
    Department of Materials Science and Metallurgy, University of Cambridge, Cambridge, UK
    Eur J Pharm Biopharm 74:109-19. 2010
    ..Thus, MRI and XmicroT may be regarded as complementary methods for studying the hydration and swelling behaviour of tablets...
  52. ncbi Application of percolation theory in the study of an extended release Verapamil hydrochloride formulation
    Tamara Gonçalves-Araújo
    Departamento de Farmacia y Tecnologia Farmaceutica, Universidad de Sevilla, C Profesor García González 2, Sevilla 41012, Spain
    Int J Pharm 361:112-7. 2008
    ..Above 20% (v/v) HPMC, an infinite cluster of excipient would be formed, ensuring uniform hydration, maintaining integrity of the system and controlling the drug release...
  53. ncbi The influence of excipients on drug release from hydroxypropyl methylcellulose matrices
    Marina Levina
    Colorcon Limited, Flagship House, Victory Way, Crossways, Dartford, Kent DA2 6QD, UK
    J Pharm Sci 93:2746-54. 2004
    ..cellulose (MCC), and partially pregelatinized maize starch (Starch 1500) on drug release from hydroxypropyl methylcellulose (HPMC, hypromellose) matrix system has been investigated...
  54. ncbi Characterization and optimization of AMG 517 supersaturatable self-emulsifying drug delivery system (S-SEDDS) for improved oral absorption
    Ping Gao
    Department of Pharmaceutics, Amgen Inc, Thousand Oaks, California 91320, USA
    J Pharm Sci 98:516-28. 2009
    ..This case demonstrates that S-SEDDS technology is an effective approach for improving the rate and extent of absorption of poorly soluble drugs...
  55. ncbi Comparative evaluation of the hypolipidemic effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in high fat-fed mice
    Su Jeong Ban
    Department of Food Science and Nutrition, Kyungpook National University, Daegu 702 701, Republic of Korea
    Food Chem Toxicol 50:130-4. 2012
    The effect of hydroxyethyl methylcellulose (HEMC), in comparison with hydroxypropyl methylcellulose (HPMC), on the body weight and lipid metabolism in mice fed with high fat diet was investigated...
  56. ncbi Hydroxypropyl methylcellulose acetate succinate-based spray-dried dispersions: an overview
    Dwayne T Friesen
    Bend Research Inc, 64550 Research Road, Bend, Oregon 97701, USA
    Mol Pharm 5:1003-19. 2008
    Spray-dried dispersions (SDDs) of low-solubility drugs have been prepared using the polymer hydroxypropyl methylcellulose acetate succinate (HPMCAS)...
  57. ncbi Formulation optimization of solid dispersion of mosapride hydrochloride
    Hye Jin Kim
    College of Pharmacy, Sookmyung Women s University, Seoul 140 742, Korea
    Arch Pharm Res 34:1467-75. 2011
    ..These results indicate that the solid dispersion formulation containing PVP/Eudragit RSPO or HPMC mixture could serve as a good controlled-release system for MSP...
  58. ncbi Effect of hydroxypropyl methylcellulose on obesity and glucose metabolism in a diet-induced obesity mouse model
    Shao Ching Hung
    The Dow Chemical Company, Analytical Sciences, Midland, Michigan 48667, USA
    J Diabetes 3:158-67. 2011
    To investigate the effect of hydroxypropyl methylcellulose (HPMC) on weight loss and metabolic disorders associated with obesity using a high-fat diet-induced obese mouse model under a high-fat diet regimen.
  59. ncbi Studies of hydroxypropyl methylcellulose donut-shaped tablets
    K Cheng
    Zhongkun Pharmaceutical Research Institute, School of Pharmacy, China Pharmaceutical University, Nanjing, People s Republic of China
    Drug Dev Ind Pharm 25:1067-71. 1999
    ..As the drug solubility increased, the duration of linear drug release was shortened. However, three stirring rates (50 rpm, 100 rpm, 150 rpm) had little effect on the drug release...
  60. ncbi Crystallization of hydrocortisone acetate: influence of polymers
    S L Raghavan
    Medway Sciences, NRI University of Greenwich, Central Avenue, Maritime, Kent ME44TB, Chatham, UK
    Int J Pharm 212:213-21. 2001
    The influence of hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), polyvinyl pyrrolidone (PVP) and polyethylene glycol (PEG400) on the crystallization of hydrocortisone acetate (HA) was studied...
  61. ncbi Development of a solid supersaturatable self-emulsifying drug delivery system of docetaxel with improved dissolution and bioavailability
    Ying Chen
    Department of Pharmacy, Wuhan General Hospital of Guangzhou Command, No 627, Wuluo Road, Wuchang Region, Wuhan 430070, PR China
    Biol Pharm Bull 34:278-86. 2011
    ..docetaxel (DTX-S-sSEDDS) was prepared by spray drying, using lactose as the solid carrier and hydroxypropyl methylcellulose (HPMC) as the supersaturation promoter...
  62. ncbi Hydroxypropylmethylcellulose and methylcellulose consumption reduce postprandial insulinemia in overweight and obese men and women
    Kevin C Maki
    Provident Clinical Research, Bloomington, IN, USA
    J Nutr 138:292-6. 2008
    Hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) are modified cellulose dietary fibers that generate viscous solutions in the gastrointestinal (GI) tract...
  63. ncbi Safety assessment of hydroxypropyl methylcellulose as a food ingredient
    George A Burdock
    Burdock Group, 2001 9th Ave Suite 301, Vero Beach, FL 32960, USA
    Food Chem Toxicol 45:2341-51. 2007
    ..047 mg/kg body weight/day...
  64. ncbi Development of controlled release captopril granules coated with ethylcellulose and methylcellulose by fluid bed dryer
    Hellen Karine Stulzer
    Departamento de Ciencias Farmaceuticas, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Drug Deliv 15:11-8. 2008
    Captopril granules of controlled release with different polymers as ethylcellulose, ethyl/methylcellulose, and immediate release with polyvinylpyrrolidone (PVP) were developed by fluid bed dryer technique...
  65. ncbi Controlled release of dual drug-loaded hydroxypropyl methylcellulose matrix tablet using drug-containing polymeric coatings
    B J Lee
    Biological Rhythm and Controlled Release Laboratory, College of Pharmacy, Kangwon National University, Chuncheon, South Korea
    Int J Pharm 188:71-80. 1999
    ..The dual drug-loaded coating method is also interesting for the modified release of poorly water-soluble drugs because solubilizers and other additives can be added in drug-containing polymeric coating dispersions...
  66. ncbi Controlled drug delivery from swellable hydroxypropylmethylcellulose matrices: model-based analysis of observed radial front movements
    Søren Kiil
    Department of Chemical Engineering, Technical University of Denmark, Building 229, DK 2800 Kgs, Lyngby, Denmark
    J Control Release 90:1-21. 2003
    ..The front-tracking approach illustrated is of relevance in the development of detailed and accurate models of drug delivery from swellable cylindrical matrices involving both axial and radial diffusion...
  67. ncbi Simultaneous probing of swelling, erosion and dissolution by NMR-microimaging--effect of solubility of additives on HPMC matrix tablets
    Farhad Tajarobi
    AstraZeneca R and D, SE 431 83 Molndal, Sweden
    Eur J Pharm Sci 37:89-97. 2009
    ..method has been used to study the influence of the solubility of additives in extended release hydroxypropyl methylcellulose (HPMC) matrix tablets...
  68. ncbi Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)
    J Siepmann
    College of Pharmacy, Universite d Angers, 16 Boulevard Daviers, 49100, Angers, France
    Adv Drug Deliv Rev 48:139-57. 2001
    ..the spectrum of mathematical models that have been developed to describe drug release from hydroxypropyl methylcellulose (HPMC)-based pharmaceutical devices...
  69. ncbi Natural course of intraocular pressure after cataract surgery with sodium hyaluronate 1% versus hydroxypropylmethylcellulose 2%
    Georg Rainer
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Ophthalmology 114:1089-93. 2007
    ..To investigate the natural course of intraocular pressure (IOP) after small-incision cataract surgery with sodium hyaluronate 1% versus hydroxypropylmethylcellulose 2%...
  70. ncbi Simultaneous FTIR spectroscopic imaging and visible photography to monitor tablet dissolution and drug release
    Sergei G Kazarian
    Department of Chemical Engineering, Imperial College London, London, SW7 2AZ, UK
    Pharm Res 25:853-60. 2008
    Previous studies of hydroxypropyl methylcellulose (HPMC)-based tablet during exposure to water showed a number of 'fronts' moving into the tablet but led to contradictory interpretations...
  71. ncbi Dynamic coating using methylcellulose and polysorbate 20 for nondenaturing electrophoresis of proteins on plastic microchips
    Mohamad Reza Mohamadi
    Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya, Japan
    Electrophoresis 28:830-6. 2007
    A dynamic coating using methylcellulose (MC) and a nonionic detergent (polysorbate 20) was developed, which controlled protein adsorption onto the surface of microchannels on a microchip made of poly(methyl methacrylate) (PMMA)...
  72. ncbi A silanized hydroxypropyl methylcellulose hydrogel for the three-dimensional culture of chondrocytes
    C Vinatier
    INSERM EM 9903, Research Center on Materials with Biological Interest, School of Dental Surgery, University of Nantes, 1 Place Alexis Ricordeau 44042, Nantes Cedex 1, France
    Biomaterials 26:6643-51. 2005
    ..We have developed an injectable and self-setting hydrogel consisting of hydroxypropyl methylcellulose grafted with silanol groups (Si-HPMC)...
  73. ncbi Influence of hydroxypropyl methylcellulose on drug release pattern of a gastroretentive floating drug delivery system using a 3(2) full factorial design
    Kalpana Swain
    College of Pharmaceutical Sciences, Mohuda, Berhampur, Orissa, India
    Pharm Dev Technol 14:193-8. 2009
    ..to study the effect of formulation variables like various viscosity grades and contents of hydroxypropyl methylcellulose (HPMC) and their interactions on response variables...
  74. ncbi An integrated system for dissolution studies and magnetic resonance imaging of controlled release, polymer-based dosage forms-a tool for quantitative assessment of hydrogel formation processes
    Piotr Kulinowski
    Department of Magnetic Resonance Imaging, Institute of Nuclear Physics, Polish Academy of Sciences, ul Radzikowskiego 152, 31 342 Krakow, Poland
    J Pharm Biomed Anal 48:685-93. 2008
    ..This method seems to be a very promising tool for examining properties of new formulations of CR, polymer-based dosage forms or for comparison of generic and originator dosage forms before carrying out bioequivalence studies...
  75. pmc Intraocular pressure rise after small incision cataract surgery: a randomised intraindividual comparison of two dispersive viscoelastic agents
    G Rainer
    Department of Ophthalmology, University of Vienna, Austria
    Br J Ophthalmol 85:139-42. 2001
    To evaluate the effects of the dispersive viscoelastic agents Ocucoat (hydroxypropyl methylcellulose 2%) and Viscoat (sodium chondroitin sulphate 4%-sodium hyaluronate 3%) on postoperative intraocular pressure (IOP) after bilateral small ..
  76. pmc Formulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres
    Sk Md Athar Alli
    Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India
    Int J Nanomedicine 6:619-29. 2011
    ..Test results depict statistically significant effects of the hypromellose grade and their concentration on the performance and release profile of formulations...
  77. ncbi Utility of hydroxypropylmethylcellulose acetate succinate (HPMCAS) for initiation and maintenance of drug supersaturation in the GI milieu
    William Curatolo
    Pfizer Global R and D, Groton, CT 06340, USA
    Pharm Res 26:1419-31. 2009
    ..To identify materials and processes which effect supersaturation of the GI milieu for low solubility drugs in order to increase oral bioavailability...
  78. ncbi Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation
    Kenan Gong
    Clean Materials Technology Group, Department of Chemistry, University College London, Christopher Ingold Building, 20 Gordon Street, London WC1H 0AJ, UK
    J Pharm Biomed Anal 48:1112-9. 2008
    ..For the HPMC-indomethacin drug composite processed at 130 degrees C/17.2 MPa, drug release behavior obeyed a n-power law (n=0.54)...
  79. ncbi Formulation and release characteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin
    B J Lee
    Biological Rhythm and Controlled Release Laboratory, College of Pharmacy, Kangwon National University, Chuncheon, Korea
    Drug Dev Ind Pharm 25:493-501. 1999
    A hydroxypropyl methylcellulose (HPMC) matrix tablet containing melatonin (MT) was formulated as a function of HPMC viscosity, drug loading, type and amount of disintegrant, lubricant and glidant, and aqueous polymeric coating level and ..
  80. ncbi Preparation of buccal patch composed of carbopol, poloxamer and hydroxypropyl methylcellulose
    Myung Kwan Chun
    College of Pharmacy, Chosun University, Gwangju, Korea 501 759
    Arch Pharm Res 26:973-8. 2003
    A polymeric film composed of Carbopol, Poloxamer and hydroxypropyl methylcellulose was prepared to develop a buccal patch and the effects of composition of the film on adhesion time, swelling ratio, and dissolution of the film were ..
  81. ncbi Effect of Healon5 and 4 other viscoelastic substances on intraocular pressure and endothelium after cataract surgery
    M P Holzer
    Department of Ophthalmology, Humboldt University Berlin, Campus Virchow Klinikum, Germany
    J Cataract Refract Surg 27:213-8. 2001
    ..The OVDs used were OcuCoat and Celoftal (hydroxypropyl methylcellulose 2.0%), Viscoat (sodium hyaluronate 3.0%-chondroitin sulfate 4.0%), Healon GV (sodium hyaluronate 1...
  82. ncbi Towards elucidation of the drug release mechanism from compressed hydrophilic matrices made of cellulose ethers. II. Evaluation of a possible swelling-controlled drug release mechanism using dimensionless analysis
    Carmen Ferrero
    School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    J Control Release 141:223-33. 2010
    ..50, 0.45 and 0.43 for the slab (film), the cylindrical (disk) and the spherical geometry, respectively, as calculated from drug release data using the power law equation...
  83. ncbi Investigation of water mobility and diffusivity in hydrating micronized low-substituted hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and hydroxypropyl cellulose matrix tablets by magnetic resonance imaging (MRI)
    Masazumi Kojima
    Tokyo Pharmaceutical Research Center, Pharmaceutical Technology Research Laboratories, Daiichi Pharmaceutical Co, Ltd, Edogaea ku, Japan
    Chem Pharm Bull (Tokyo) 50:1621-4. 2002
    ..Furthermore, the correlation between the T(2) of (1)H proton in the gel-layer of the tablets and the drug release rate from the tablets was observed...
  84. ncbi Influence of beta-cyclodextrin complexation on carbamazepine release from hydroxypropyl methylcellulose matrix tablets
    Letícia S Koester
    Programa de Pós Graduação em Ciências Farmacêuticas, Porto Alegre, RS, Brazil
    Eur J Pharm Biopharm 55:85-91. 2003
    ..simply mixed and subsequently incorporated in hydrophilic matrix tablets containing 15 or 30% hydroxypropyl methylcellulose were evaluated...
  85. ncbi The use of hypromellose in oral drug delivery
    Chi L Li
    GlaxoSmithKline Pharmaceuticals, Pharmaceutical Development, New Frontiers Science Park South, Third Avenue, Harlow, Essex, CM19 5AW, UK
    J Pharm Pharmacol 57:533-46. 2005
    ....
  86. ncbi [Description of the release of sodium ferulate from hydroxypropyl methylcellulose based matrix tablets in vitro]
    Feng Qian Li
    Department of Pharmaceutical Sciences, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Yao Xue Xue Bao 39:389-91. 2004
    To elucidate the mechanism and to present suitable models for the release of sodium ferulate (SF) from hydroxypropyl methylcellulose (HPMC) based matrix tablets.
  87. ncbi Preparation and evaluation of nimesulide-loaded ethylcellulose and methylcellulose nanoparticles and microparticles for oral delivery
    N R Ravikumara
    Research Center for Nanoscience and Technology, Department of Biochemistry, P G Centre, Kuvempu University Shivagangotri, Davangere 577002, India
    J Biomater Appl 24:47-64. 2009
    ..assess and compare with a range of surfactant-coated, nimesulide-free, and nimesulide-loaded ethylcellulose/methylcellulose (EC/MC) nanoparticles that were prepared by varying drug concentration (ED/MD), polymer concentration (EP/MP),..
  88. ncbi Quantitative ultra-fast MRI of HPMC swelling and dissolution
    Ya ying Chen
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
    J Pharm Sci 99:3462-72. 2010
    ..For the first time MRI evidence is presented for a transition swollen glassy layer which resides between the outer edge of the dry tablet core and the inner edge of the gel layer...
  89. ncbi Magnetic resonance imaging study of the swelling kinetics of hydroxypropylmethylcellulose (HPMC) in water
    Jadwiga Tritt-Goc
    Institute of Molecular Physics, Polish Academy of Sciences, M Smoluchowskego 17, 60 179 Poznan, Poland
    J Control Release 80:79-86. 2002
    ..It was also observed that radial swelling is larger for the system composed of HPMC and water at pH=6 than at pH=2...
  90. ncbi The swelling properties of hydroxypropyl methyl cellulose loaded with tetracycline hydrochloride: magnetic resonance imaging study
    Joanna Kowalczuk
    Institute of Molecular Physics, Polish Academy of Sciences, M Smoluchowskiego 17, 60 179 Poznan, Poland
    Solid State Nucl Magn Reson 25:35-41. 2004
    ..On the other hand the swelling properties of the matrix increase with the amount of drug in the matrix...
  91. ncbi Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate
    R Bettini
    Department of Pharmacy, University of Parma, Parco Area delle Scienze 27/A, 43100 Parma, Italy
    J Control Release 70:383-91. 2001
    ..1%, nitrofutantoin 0.02% w/v,) from hydroxypropyl methylcellulose (HPMC) matrices by concomitantly studying swelling, diffusion and erosion fronts movement and drug delivery...
  92. pmc Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: a technical note
    Hamid A Merchant
    Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    AAPS PharmSciTech 7:78. 2006
  93. ncbi Combined approach of FTIR imaging and conventional dissolution tests applied to drug release
    Jaap van der Weerd
    Department of Chemical Engineering and Chemical Technology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    J Control Release 98:295-305. 2004
    ..A tablet composed of hydroxypropyl methylcellulose (HPMC) and niacinamide was prepared and analysed using this setup...
  94. ncbi Multidetector CT enteroclysis versus barium enteroclysis with methylcellulose in patients with suspected small bowel disease
    Laura Maria Minordi
    Dipartimento di Bioimmagini e Scienze Radiologiche, Istituto di Radiologia, UCSC, L go A Gemelli, Rome, Italy
    Eur Radiol 16:1527-36. 2006
    ..to evaluate the diagnostic accuracy of multidetector-CT enteroclysis (MDCT-E) versus barium enteroclysis with methylcellulose (BE) in clinically selected patients with suspected small bowel disease...
  95. ncbi Hydroxypropyl methylcellulose: A better submucosal fluid cushion for endoscopic mucosal resection
    Arnaldo B Feitoza
    Developmental Endoscopy Unit, Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA
    Gastrointest Endosc 57:41-7. 2003
    ..The feasibility, durability, and histologic response to submucosal fluid cushions created by injection of hydroxypropyl methylcellulose were studied in the esophagus of pigs.
  96. ncbi Evaluation of an injectable bone substitute (betaTCP/hydroxyapatite/hydroxy-propyl-methyl-cellulose) in severely osteopenic and aged rats
    S Blouin
    INSERM, EMI 0335 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    J Biomed Mater Res A 78:570-80. 2006
    ..IBS1 induced new bone formation shortly after implantation but both IBS1 and woven bone were resorbed without inducing lamellar bone. Biomaterial trials must be conducted with long-term implantation periods, in aged osteoporotic animals...
  97. ncbi Polymer particle erosion controlling drug release. I. Factors influencing drug release and characterization of the release mechanism
    S Zuleger
    , , , D-40225, , Germany
    Int J Pharm 217:139-52. 2001
    ....
  98. pmc Controlled release of drug via methylcellulose-carboxyvinylpolymer interpolymer complex solid dispersion
    Tetsuya Ozeki
    Department of Pharmaceutics and Drug Delivery, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    AAPS PharmSciTech 6:E231-6. 2005
    ..release of phenacetin (PHE) from solid dispersion by the formation of an interpolymer complex between methylcellulose (MC) and carboxyvinylpolymer (CP)...
  99. ncbi Controlled and complete release of a model poorly water-soluble drug, prednisolone, from hydroxypropyl methylcellulose matrix tablets using (SBE)(7m)-beta-cyclodextrin as a solubilizing agent
    V M Rao
    The Department of Pharmaceutical Chemistry, 2095 Constant Avenue, The University of Kansas, Lawrence, Kansas 66047, USA
    J Pharm Sci 90:807-16. 2001
    Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)-based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug ..
  100. ncbi The effect of citric acid added to hydroxypropyl methylcellulose (HPMC) matrix tablets on the release profile of vinpocetine
    Shufang Nie
    Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, PR China
    Drug Dev Ind Pharm 30:627-35. 2004
    ..The sustained-release matrix tablets of vinpocetine were prepared by direct compression using hydroxypropyl methylcellulose (HPMC) and different amounts of citric acid to set up a system bringing about gradual release of this drug...
  101. ncbi Intracellular adenosine 5'-triphosphate, adenosine 5'-diphosphate, and adenosine 5'-monophosphate detection by short-end injection capillary electrophoresis using methylcellulose as the effective electroosmostic flow suppressor
    Angelo Zinellu
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Electrophoresis 29:3069-73. 2008
    ..Moreover, the use of methylcellulose (MC) as run buffer additive to suppress EOF permits to further reduce the migration times of analytes...

Research Grants62

  1. AP Endonuclease 2 in hematopoietic stem cell maintenance
    Carol E Schrader; Fiscal Year: 2012
    ..Untreated and irradiated HSC will be analyzed functionally in clonogenic survival assays using methylcellulose cultures and also by transplantation into irradiated recipient mice...
  2. Niche-induced Signaling in Progenitor B Cell Development
    LESLIE ERIC SILBERSTEIN; Fiscal Year: 2013
    ..Aim 1 will define how FAK regulates progenitor B cell growth and survival. Both in vitro methylcellulose based colony cell forming cell assays as well as in vivo adoptive transfer experiments will be used to ..
  3. Zosteric Acid Integrated Thermo-reversible Gels for Preventing Surgical Adhesions
    Bi min Newby; Fiscal Year: 2012
    ....
  4. Development of Biomaterials that Release Therapeutic Agents to Modulate Inflammat
    Ryan J Gilbert; Fiscal Year: 2010
    ..Here, we present a novel biomaterial blend composed of agarose and methylcellulose. Prior preliminary data has shown that these blends exist as a liquid at room temperature and quickly ..
  5. Multifunctional bone putty for craniomaxillofacial bone repair
    AMBALANGODAGE CHAMPA JAYASURIYA; Fiscal Year: 2013
    ..The bone putty will be implanted into a rat calvarial critical size defect. The outcomes of the bone regeneration from bone putty will be compared with commercially available calcium phosphate cement or collagen sponge with BMP-2. ..
  6. Impact of Fiber Fermentation on Fecal Incontinence
    Donna Bliss; Fiscal Year: 2007
    ..stool will be randomized to receive placebo or 16 g of total fiber/d in gum Arabic, psyllium, or carboxy-methylcellulose, representing three levels of ferment ability (completely, moderately, and non-fermentable, respectively)...
  7. Acute Phase Treatment of Spinal Cord Injury Using Hydrogel Blends Loaded with Glu
    Ryan Gilbert; Fiscal Year: 2009
    ..Here, we present a novel biomaterial blend composed of agarose and methylcellulose. Our preliminary data shows that these blends exist as a liquid at room temperature and quickly solidify at ..
  8. IN VIVO MECHANISMS OF LOCAL STATIN-INDUCED BONE
    Richard Reinhardt; Fiscal Year: 2004
    ..active drug (simvastatin) to be delivered supraperiosteally at varying doses in a sustained-release vehicle (methylcellulose) under an occlusive membrane (polylactic acid) on one side of the mandible, and control vehicle/membrane on ..
  9. ALLOGENEIC LEUKOCYTE INFUSIONS FOR BREAST CANCER
    SCOTT BEARMAN; Fiscal Year: 2000
    ..In addition, myeloid (CFU-GM) and erythroid (BFU-E) progenitors were grown in methylcellulose and all colonies evaluated were of donor origin by FISH...
  10. CELL WALL SYNTHESIS DURING GROWTH & DIVISION OF BACTERIA
    Stephen Cooper; Fiscal Year: 1993
    ..Both the membrane-elution method and the standard method will be used to analyze the stability of peptidoglycan in different bacteria under identical conditions...
  11. REGULATION OF HUMAN MEGAKARYOCYTOPOIESIS
    Alan Gewirtz; Fiscal Year: 1992
    ..will be 1) hematopoietic cell culture in a variety of semi-solid support matricies including plasma clot and methylcellulose, 2) counterflow centrigual elutriation for the isolation and enrichment of human bone marrow megakaryocytes, ..
  12. BIOCHEMISTRY OF RNA TUMOR VIRUS REPLICATION
    RALPH SMITH; Fiscal Year: 1990
    ..by an avian osteopetrosis virus, MAV-2(0), will be characterized by examining the colonies that grow in a methylcellulose-based semi-solid medium...
  13. HIV vectors for stem cell and intrakine gene delivery
    Richard Sutton; Fiscal Year: 2004
    ..Readout will include methylcellulose. colony and LT-CIC assays, and repopulation of NOD/SCID mice by transduced cells...
  14. TGF-B1/IGF-I TO TREAT CHRONIC WOUNDS
    Samuel Lynch; Fiscal Year: 1993
    ..on wounds in diabetic mice of TGF-beta1, IGF-I or the combination of TGF-beta1/IGF-I delivered in a 2% methylcellulose gel vehicle...
  15. HEMATOPOIETIC BLAST CELL COLONIES FUNCTIONAL CAPACITY
    Saul Sharkis; Fiscal Year: 1990
    ..of primitive, agranular, medium-sized, refractile, undifferentiated "blast" cells will be plucked from the methylcellulose, and their functional capacity will be determined...
  16. MOLECULAR BASIS OF BREAST CELL TRANSFORMATION
    Jose Russo; Fiscal Year: 2000
    ..This correlates with similar loss observed in primary breast cancer. Thus this in vitro model mimics the in vivo situation. ..
  17. Hematopoietic Support by Adipose-Derived Stromal Cells
    Jeffrey Gimble; Fiscal Year: 2001
    ..and pluripotent hematopoietic progenitors in short and long term cultures using flow cytometric and methylcellulose assays...
  18. HIV INFECTION OF BONE MARROW STROMAL CELLS
    Florence Hofman; Fiscal Year: 1990
    ..Understanding the role of HIV in altering the bone marrow microenvironment will lead to new therapeutic modalities to inhibit or reverse the effects of viral infection...
  19. ANTIHER2 CHIMERIC TCR GENE MODIFIED HSC
    James Mule; Fiscal Year: 2001
    ..the ability of HSC to self renew and to give rise to progeny myeloid and lymphoid cells by both in vitro (methylcellulose), long term bone marrow cultures, and thymic organ cultures) and in vivo (SCID-hu mice) assays...
  20. CHIMERISM IN CORD BLOOD TRANSPLANTATION IN MICE
    Rona Weinberg; Fiscal Year: 2004
    ..BMT, including competitive repopulation assay, short-term and long-term liquid cultures, and methylcellulose cultures will be employed...
  21. GENES INVOLVED IN HEMANGIOBLAST COMMITMENT FROM MESODERM
    Scott Robertson; Fiscal Year: 2002
    ..These precursors, in response to VEGF, generate blast cell colonies in methylcellulose cultures that contain both hematopoietic and endothelial precursors...
  22. ESTABLISHMENT OF PRIMATE SALIVARY GLAND CELL LINES
    Edwin Azen; Fiscal Year: 1990
    ....
  23. ROLE OF MICROSATELLITE INSTABILITY IN BREAST CANCER
    Jose Russo; Fiscal Year: 2002
    ..The knowledge gained through this exploratory work will establish the basis for more in dept studies in the role of mismatch repair in breast cancer. ..
  24. Genomic Markers of Breast Cancer Prevention Induced by hCG in Women at High Risk
    Jose Russo; Fiscal Year: 2008
    ..This knowledge will serve as the basis for establishing novel genomic signatures as intermediate biomarkers for larger preventive clinical trials at the completion of this project. [unreadable] [unreadable] [unreadable]..
  25. 4-Hydroxyestradiol Receptor in Breast Cancer
    Jose Russo; Fiscal Year: 2005
    ..This plan is in line with goals 1 and 3 of the Breast Cancer Progress Review Group to better understand the biology of the normal mammary gland and of precancerous lesions. ..
  26. Epigenetic Changes Induced by Estrogens and Xenoestrogens in Breast Cancer
    Jose Russo; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Fox Chase Cancer Center Breast Cancer Tissue Resources
    Jose Russo; Fiscal Year: 2008
    ..abstract_text> ..
  28. Genomic Basis of Reproductive History on Breast Cancer
    Jose Russo; Fiscal Year: 2006
    ..abstract_text> ..
  29. Anti-proliferative Effects of D-limonene against Prosta*
    Sanjay Gupta; Fiscal Year: 2005
    ..Successful completion of this application will establish the cancer chemopreventive and/or therapeutic potential of D-limonene against prostate cancer and mechanisms involved with its anti-proliferative response. ..
  30. BEHAVIORAL PHARMACOLOGY OF OPIOIDS
    CHARLES FRANCE; Fiscal Year: 2003
    ....
  31. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Our long-term goal is to delineate the multifunctional roles of CP in brain fluid homeostasis. ..
  32. Prostate Cancer Chemoprevention by Apigenin
    Sanjay Gupta; Fiscal Year: 2003
    ..These studies could be considered as a starting point for an expanded program for the development of apigenin as a promising agent against CaP in humans. ..
  33. Fourth International Conf. on Relaxin & Related Peptides
    ORRIN SHERWOOD; Fiscal Year: 2004
    ..Conference web site: http://www.life.uiuc.edu/relaxin2004/ ..
  34. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Translation: Ap is an expedient marker to analyze aging effects on ISF-CSF relationships, and the compromised solute clearance by malfunctioning barrier systems. This sheds light on neurodegeneration. ..
  35. Effect of ART on 3D Oral Epithelium & KSHV/RRV Infection
    Craig Meyers; Fiscal Year: 2008
    ..Our studies in this application and future studies evolving from them will have a significant impact on health care. [unreadable] [unreadable] [unreadable]..
  36. Polarity of Redox Control and Risk of Injury in the Alveolar Epithelium
    Dean P Jones; Fiscal Year: 2010
    ..The results of these proposed studies will provide an unprecedented knowledge concerning the subcellular compartmentalization of oxidative stress in the lung. ..
  37. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2009
    ..Completion of the proposed studies will provide a 'head start'to initiate clinical trials in prostate cancer patients and/or high-risk individuals. ..
  38. CHRONIC ETHANOL: MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS
    LOU ANN SCISM BROWN; Fiscal Year: 2010
    ..3) Determine if strategies to relieve ER stress will rescue the alcoholic AT2 cell from its pro-apoptotic phenotype. 4) Determine if relief of ER stress will rescue AT2 cell apoptosis in the alcoholic lung during endotoxemia. ..
  39. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  40. Genetic Analysis of Papillomavirus Virion Morphogenesis
    Craig Meyers; Fiscal Year: 2009
    ....
  41. Diabetes: Implant Integration, Success, and Benefit
    Thomas W Oates; Fiscal Year: 2010
    ..Ultimately, this information will contribute to the establishment of evidence-based guidelines for the assessment and application of dental implant therapy for patients with diabetes. ..
  42. Investigating the Molecular Mechanism of Hexose-induced Stress in Lens and Retina
    Peter F Kador; Fiscal Year: 2010
    ..Moreover, these studies should help identify new drug targets for the treatment of these diabetic complications. ..
  43. Erythropoietin receptors in breast cancer
    MURAT ARCASOY; Fiscal Year: 2008
    ..abstract_text> ..
  44. VIRUS SPECIFIC FACTORS OF HSV TO CORNEAL DISEASE
    CURTIS BRANDT; Fiscal Year: 2008
    ..g. isoform A is involved with function B). These studies will add to our knowledge of the role of the US1 protein in ocular HSV infections and may lead to improved therapies. ..
  45. HPV DIFFERENTIATION DEPENDENT REPLICATION
    Craig Meyers; Fiscal Year: 2003
    ..abstract_text> ..
  46. ALCOHOLISM:ALTERED ALVEOLAR MATRIX AND ACUTE LUNG INJURY
    Lou Ann Brown; Fiscal Year: 2003
    ....
  47. GHB abuse: chemistry and neurobiology
    CHARLES FRANCE; Fiscal Year: 2003
    ..abstract_text> ..
  48. Inhibition of Prostate Carcinogenesis by Apigenin
    Sanjay Gupta; Fiscal Year: 2003
    ..A successful completion of this application will set a platform to define the role of apigenin as a promising agent against prevention and possibly therapy of prostate cancer in humans. ..
  49. The Role of Chemokines in Metastatic Prostate Cancer
    Russell Taichman; Fiscal Year: 2003
    ..abstract_text> ..
  50. OCULAR PATHOGENESIS AND THERAPY OF BACTERIAL KERATITIS
    James Hill; Fiscal Year: 2001
    ....
  51. Bone and the Hematopoietic System
    Russell Taichman; Fiscal Year: 2004
    ..These investigations will ultimately lead to new strategies for the treatment of hematopoietic and osseous disorders. ..
  52. Increased Access to Emergency Contraceptive Pills
    Elizabeth Raymond; Fiscal Year: 2004
    ..These secondary analyses should help explain the primary biologic outcomes and should be useful in the development of counseling messages and service protocols in the future. ..
  53. Microbicidal peptides to prevent viral STD infection
    CURTIS BRANDT; Fiscal Year: 2004
    ..abstract_text> ..
  54. Novel anti-HIV carrageenan-based on microbicides
    David Phillips; Fiscal Year: 2004
    ..The applicant believes that the proposed research will result in the pre-clinical development of a safe, novel microbicide that is superior in efficacy against HIV. ..
  55. PREVENTION OF DENTAL CARIES
    Shozo Takagi; Fiscal Year: 2005
    ....
  56. Reactivation of GSTP1 Gene by Green Tea Polyphenols
    Sanjay Gupta; Fiscal Year: 2005
    ..abstract_text> ..
  57. Hormonal Regulation of the Cervix During Pregnancy
    ORRIN SHERWOOD; Fiscal Year: 2006
    ..Treatment with RU 486 alone and in combination with exogenous relaxin will be done at term with relaxin-deficient rats. ..
  58. Noninvasive breath condensate: ARDS risk in alcoholics
    Lou Ann Brown; Fiscal Year: 2006
    ..abstract_text> ..
  59. Promoters for Glaucoma Gene Therapy
    CURTIS BRANDT; Fiscal Year: 2007
    ..abstract_text> ..
  60. Multifunctional Antioxidants as Anti-Cataract Agents
    Peter Kador; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  61. Aging, Herpesviruses, and Alzheimer's Disease
    James Hill; Fiscal Year: 2007
    ..This project could lead to strategies to identify high-risk individuals who would be treated with antivirals, thus reducing their risk of developing AD. [unreadable] [unreadable]..
  62. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..