Summary: A thiol-containing amino acid formed by a demethylation of METHIONINE.

Top Publications

  1. ncbi A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    P Frosst
    Nat Genet 10:111-3. 1995
  2. ncbi Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
  3. ncbi Homocysteine and cardiovascular disease
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Annu Rev Med 49:31-62. 1998
  4. ncbi Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals
    Robert Clarke
    University of Oxford, England
    Arch Intern Med 170:1622-31. 2010
  5. ncbi A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    I Weisberg
    Department of Human Genetics, McGill University Health Centre, Montreal, Quebec, H3Z 2Z3, Canada
    Mol Genet Metab 64:169-72. 1998
  6. ncbi Homocysteine metabolism
    J Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 19:217-46. 1999
  7. pmc Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy
    Daryl J Wile
    Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Diabetes Care 33:156-61. 2010
  8. ncbi Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen, Norway
    JAMA 300:795-804. 2008
  9. ncbi Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations
    Olaf Stanger
    Paracelsus Medical University Salzburg, Clinic for Heart Surgery, OGK Institute for Applied Aminoacid and Vitamin Research, Mullner Hauptstrasse 48, A 5020 Salzburg, Austria
    Expert Rev Neurother 9:1393-412. 2009
  10. pmc Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis
    David S Wald
    Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    PLoS ONE 6:e16473. 2011

Detail Information

Publications346 found, 100 shown here

  1. ncbi A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
    P Frosst
    Nat Genet 10:111-3. 1995
    ..Elevated levels of plasma homocysteine can result from genetic or nutrient-related disturbances in the trans-sulphuration or re-methylation pathways ..
  2. ncbi Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA 02118 2526, USA
    N Engl J Med 346:476-83. 2002
    In cross-sectional studies, elevated plasma homocysteine levels have been associated with poor cognition and dementia...
  3. ncbi Homocysteine and cardiovascular disease
    H Refsum
    Department of Pharmacology, University of Bergen, Norway
    Annu Rev Med 49:31-62. 1998
    An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for ..
  4. ncbi Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals
    Robert Clarke
    University of Oxford, England
    Arch Intern Med 170:1622-31. 2010
    Elevated plasma homocysteine levels have been associated with higher risks of cardiovascular disease, but the effects on disease rates of supplementation with folic acid to lower plasma homocysteine levels are uncertain...
  5. ncbi A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    I Weisberg
    Department of Human Genetics, McGill University Health Centre, Montreal, Quebec, H3Z 2Z3, Canada
    Mol Genet Metab 64:169-72. 1998
    ..A silent genetic variant, T1317C, was identified in the same exon. It was relatively infrequent (allele frequency 5%) in our study group, but was quite common in a small sample of African individuals (allele frequency 39%)...
  6. ncbi Homocysteine metabolism
    J Selhub
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 19:217-46. 1999
    b>Homocysteine is a sulfur amino acid whose metabolism stands at the intersection of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or betaine in an alternative reaction); and transsulfuration to ..
  7. pmc Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy
    Daryl J Wile
    Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Diabetes Care 33:156-61. 2010
    ..Long-term use of metformin is associated with malabsorption of vitamin B(12) (cobalamin [Cbl]) and elevated homocysteine (Hcy) and methylmalonic acid (MMA) levels, which may have deleterious effects on peripheral nerves...
  8. ncbi Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial
    Marta Ebbing
    Department of Heart Disease, Haukeland University Hospital, Jonas Liesvei 65, 5021 Bergen, Norway
    JAMA 300:795-804. 2008
    Observational studies have reported associations between circulating total homocysteine concentration and risk of cardiovascular disease. Oral administration of folic acid and vitamin B(12) can lower plasma total homocysteine levels.
  9. ncbi Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations
    Olaf Stanger
    Paracelsus Medical University Salzburg, Clinic for Heart Surgery, OGK Institute for Applied Aminoacid and Vitamin Research, Mullner Hauptstrasse 48, A 5020 Salzburg, Austria
    Expert Rev Neurother 9:1393-412. 2009
    ..This paper reviews the state of current knowledge as to how homocysteine metabolism is relevant for neurodegenerative and other neuropsychiatric diseases, with particular emphasis on ..
  10. pmc Reconciling the evidence on serum homocysteine and ischaemic heart disease: a meta-analysis
    David S Wald
    Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    PLoS ONE 6:e16473. 2011
    Results from genetic epidemiological studies suggest that raised serum homocysteine is a cause of ischaemic heart disease, but the results of randomised trials suggest otherwise...
  11. ncbi Facts and recommendations about total homocysteine determinations: an expert opinion
    Helga Refsum
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Clin Chem 50:3-32. 2004
    Measurement of plasma total homocysteine has become common as new methods have been introduced. A wide range of disorders are associated with increased concentrations of total homocysteine...
  12. ncbi Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells
    P A Outinen
    Department of Pathology and Molecular Medicine, McMaster University and the Hamilton Civic Hospitals Research Centre, Hamilton, Ontario, Canada
    Blood 94:959-67. 1999
    Alterations in the cellular redox potential by homocysteine promote endothelial cell (EC) dysfunction, an early event in the progression of atherothrombotic disease...
  13. ncbi Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism
    S Jill James
    Department of Pediatrics, University of Arkansas for Medical Sciences, and the Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Am J Clin Nutr 80:1611-7. 2004
    ..Although abnormal metabolism of methionine and homocysteine has been associated with other neurologic diseases, these pathways have not been evaluated in persons with ..
  14. pmc A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
    N M van der Put
    Department of Pediatrics, University Hospital Nijmegen, Nijmegen, The Netherlands
    Am J Hum Genet 62:1044-51. 1998
    ..Neither the homozygous nor the heterozygous state is associated with higher plasma homocysteine (Hcy) or a lower plasma folate concentration-phenomena that are evident with homozygosity for the 677(C-->T) ..
  15. ncbi Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease
    P M Ridker
    Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 285:2481-5. 2001
    ..Several novel risk factors for atherosclerosis have recently been proposed, but few comparative data exist to guide clinical use of these emerging biomarkers...
  16. ncbi Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B12 in the acute phase of atherothrombotic stroke
    Giuseppe Salemi
    Section of Neurology, Department of Clinical Neuroscience, University of Palermo, Via Gaetano La Loggia 1, 90129, Palermo, Italy
    Neurol Sci 30:361-4. 2009
    Blood levels of total homocysteine (tHcy), cysteine (Cys), total and reduced glutathione (tGSH and rGSH), folic acid (FA), and vitamin B12 (B12) change during ischemic stroke as accompaniment of the tissue damage...
  17. pmc Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study
    C S Yajnik
    Diabetes Unit, KEM Hospital and Research Centre, Pune, Maharashtra, India
    Diabetologia 51:29-38. 2008
    Raised maternal plasma total homocysteine (tHcy) concentrations predict small size at birth, which is a risk factor for type 2 diabetes mellitus...
  18. pmc Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects
    Henk J Blom
    Metabolic Unit, Department of Clinical Chemistry, Institute for Cardiovascular Research ICaR VU, VU University Medical Centre, Amsterdam, The Netherlands
    J Inherit Metab Dis 34:75-81. 2011
    This overview addresses homocysteine and folate metabolism...
  19. ncbi Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature
    T Vogel
    Pôle de gériatrie, Hopitaux Universitaires de Strasbourg, Hôpital de la Robertsau, Pavillon Schutzenberger, Strasbourg Cedex, France
    Int J Clin Pract 63:1061-7. 2009
    Elevated serum homocysteine, decreased folate and low vitamin B(12) serum levels are associated with poor cognitive function, cognitive decline and dementia...
  20. ncbi Is folic acid good for everyone?
    A David Smith
    Oxford Project to Investigate Memory and Ageing, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 87:517-33. 2008
    ..Only then can authorities develop the right strategies for the population as a whole...
  21. ncbi Homocysteine and folate concentrations in early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study
    N E Bergen
    The Generation R Study Group, Department of Obstetrics and Gynaecology Division of Obstetrics and Prenatal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    BJOG 119:739-51. 2012
    To investigate associations between early pregnancy homocysteine, folate and vitamin B12 concentrations and placental weight, birthweight and adverse pregnancy outcomes.
  22. ncbi Serum homocysteine and dementia: meta-analysis of eight cohort studies including 8669 participants
    David S Wald
    Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    Alzheimers Dement 7:412-7. 2011
    Prospective cohort studies have not been consistent in showing an association between serum homocysteine and dementia.
  23. pmc Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in puerto rican adults
    Tao Huang
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou, 310029 China
    J Nutr 141:654-9. 2011
    Although methylenetetrahydrofolate reductase (MTHFR) genetic variants are associated with plasma homocysteine (Hcy) and cardiovascular disease (CVD), little is known whether dietary fatty acid intake modulates these associations...
  24. ncbi Relation between C-reactive protein, homocysteine levels, fibrinogen, and lipoprotein levels and leukocyte and platelet counts, and 10-year risk for cardiovascular disease among healthy adults in the USA
    Chan Seok Park
    Division of Cardiology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Am J Cardiol 105:1284-8. 2010
    ..0001; >10.0 mg/L: OR 1.41, 95% CI 1.03 to 1.93, p = 0.034). The high-risk group had circulating fibrinogen, homocysteine, leukocyte, and platelet levels that were 20.98 mg/dl (95% CI 12.53 to 29.43, p <0.0001), 1...
  25. ncbi Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Trends Neurosci 26:137-46. 2003
    Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of homocysteine -- a cytotoxic sulfur-containing amino acid that can induce DNA strand breakage, oxidative stress and apoptosis...
  26. ncbi Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and meta-regression
    Roger C M Ho
    Department of Psychological Medicine, Yong Loo Lin School of Medicine, Singapore
    Am J Geriatr Psychiatry 19:607-17. 2011
    corrected] High homocysteine (Hct) has been causatively linked to Alzheimer disease (AD) and vascular dementia (VaD) in old age, but research methodologies and outcome measures are heterogeneous...
  27. pmc Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II
    Ralph Carmel
    Department of Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA
    Am J Clin Nutr 94:348S-358S. 2011
    ..Much work remains to be done...
  28. ncbi Efficacy of folic acid supplementation in stroke prevention: a meta-analysis
    Xiaobin Wang
    Mary Ann and J Milburn Smith Child Health Research Program, Children s Memorial Hospital and Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614 3394, USA
    Lancet 369:1876-82. 2007
    The efficacy of treatments that lower homocysteine concentrations in reducing the risk of cardiovascular disease remains controversial...
  29. ncbi Homocysteine and folate as risk factors for dementia and Alzheimer disease
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    Am J Clin Nutr 82:636-43. 2005
    In cross-sectional studies, elevated plasma total homocysteine (tHcy) concentrations have been associated with cognitive impairment and dementia. Incidence studies of this issue are few and have produced conflicting results.
  30. ncbi Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine
    K A Hajjar
    Department of Pediatrics, Cornell University Medical College, New York, New York 10021, USA
    J Biol Chem 273:9987-93. 1998
    ..phospholipid-binding protein annexin II, an interaction that is inhibited by the prothrombotic amino acid homocysteine. We sought to identify the tissue plasminogen activator binding domain of annexin II and to determine the ..
  31. ncbi Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease
    Rita Castro
    Centro de Patogenese Molecular, Faculdade de Farmacia da Universidade de Lisboa, Av Prof Gama Pinto, 1649 039 Lisbon, Portugal
    Clin Chem 49:1292-6. 2003
    The pathogenic mechanism of homocysteine's effect on cardiovascular risk is poorly understood...
  32. pmc Neural tube defects and folate: case far from closed
    Henk J Blom
    Laboratory of Pediatrics and Neurology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Post Office Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Neurosci 7:724-31. 2006
    ..Exploring the methylation hypothesis could direct us towards additional strategies to prevent neural tube defects...
  33. ncbi Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Ilias, Gerakas Attikis, Athens, Greece
    Eur Heart J 30:6-15. 2009
    Plasma total homocysteine (Hcy) has been associated with cardiovascular risk in multiple large-scale epidemiological studies, and it has been considered as an independent risk factor for atherosclerosis...
  34. ncbi Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women
    Svetlana V Konstantinova
    Department of Public Health and Primary Health Care, University of Bergen, Bergen 5020, Norway
    J Nutr 138:914-20. 2008
    ..and is the immediate precursor of betaine, which serves as a methyl group donor in a reaction converting homocysteine to methionine...
  35. ncbi Homocysteine and depression in later life
    Osvaldo P Almeida
    FRANZCP, Western Australian Centre for Health and Ageing, University of Western Australia, Mail Box M573, 35 Stirling Hwy, Crawley, WA 6009, Australia
    Arch Gen Psychiatry 65:1286-94. 2008
    The prevalence of depression in later life increases with plasma total homocysteine concentration (tHcy). High tHcy accounts for about 15% of prevalent cases, but observational studies are prone to confounding and bias...
  36. pmc Genetics of homocysteine metabolism and associated disorders
    S Brustolin
    Servico de Genetica Medica, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brasil
    Braz J Med Biol Res 43:1-7. 2010
    b>Homocysteine is a sulfur-containing amino acid derived from the metabolism of methionine, an essential amino acid, and is metabolized by one of two pathways: remethylation or transsulfuration...
  37. ncbi The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation
    Smriti Murali Krishna
    The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, James Cook Drive, Douglas, Townsville, Qld 4811, Australia
    Atherosclerosis 228:295-305. 2013
    Previous studies have suggested that homocysteine (Hcy) has wide-ranging biological effects, including accelerating atherosclerosis, impairing post injury endothelial repair and function, deregulating lipid metabolism and inducing ..
  38. ncbi Plasma homocysteine in schizophrenia: determinants and clinical correlations in Tunisian patients free from antipsychotics
    Noomen Bouaziz
    Research Unit 03 04 Schizophrenia and Department of Psychiatry F, Razi Hospital, Mannouba, Tunisia
    Psychiatry Res 179:24-9. 2010
    ..Plasma homocysteine (Hcy), folate, and vitamin B12, as well as the C677T methylene tetrahydrofolate reductase (MTHFR) polymorphism, ..
  39. ncbi Association of omega-3 fatty acids and homocysteine concentrations in pre-eclampsia
    Asmita Kulkarni
    Dept of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune Satara Road, Pune 411043, Maharashtra, India
    Clin Nutr 30:60-4. 2011
    The present study examines the associations of folic acid, vitamin B₁₂ and omega-3 fatty acids and increased homocysteine which are implicated in the pathology of pre-eclampsia.
  40. ncbi Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer
    Shumin M Zhang
    Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
    J Natl Cancer Inst 95:373-80. 2003
    ..However, data relating plasma folate levels to breast cancer risk are sparse. We investigated the association between plasma folate and other vitamins with breast cancer in a prospective, nested case-control study...
  41. pmc Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial
    A David Smith
    Oxford Project to Investigate Memory and Ageing, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e12244. 2010
    ..b>Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia...
  42. pmc Quo vadis: whither homocysteine research?
    Jacob Joseph
    Department of Medicine, Cardiology Section 111, VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Cardiovasc Toxicol 9:53-63. 2009
    ..Several negative studies on the role of homocysteine-lowering B-vitamin therapy in reducing the risk of atherothrombotic cardiovascular disease have dampened ..
  43. ncbi Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study
    Raoul P Kloppenborg
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 216:461-6. 2011
    High homocysteine level is a risk factor for atherosclerosis and has been associated with lacunar infarcts (LIs), white matter lesions (WML) and cognitive dysfunction...
  44. ncbi Homocysteine level and risk of fracture: A meta-analysis and systematic review
    Jun Yang
    Department of Surgery, First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Bone 51:376-82. 2012
    ..We investigated this association between homocysteine (Hcy) levels in patients with fracture and unaffected controls by conducting a meta-analysis and systematic ..
  45. pmc No effect of folic acid supplementation on global DNA methylation in men and women with moderately elevated homocysteine
    Audrey Y Jung
    Department of Epidemiology, Biostatistics, and HTA, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    PLoS ONE 6:e24976. 2011
    ..of folic acid would increase global DNA methylation compared with placebo in individuals with elevated plasma homocysteine. We also investigated if these effects were modified by MTHFR C677T genotype...
  46. pmc Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials
    Michael V Holmes
    Research Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 378:584-94. 2011
    The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke...
  47. ncbi Relation of plasma glycine, serine, and homocysteine levels to schizophrenia symptoms and medication type
    Guy Neeman
    Ezrath Nashim Herzog Memorial Hospital, P O Box 3900, Jerusalem 91035, Israel
    Am J Psychiatry 162:1738-40. 2005
    Altered glycine and homocysteine levels may contribute to N-methyl-D-aspartate receptor dysfunction in schizophrenia...
  48. ncbi Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
    Celeste A de Jager
    OPTIMA, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Int J Geriatr Psychiatry 27:592-600. 2012
    b>Homocysteine is a risk factor for Alzheimer's disease. In the first report on the VITACOG trial, we showed that homocysteine-lowering treatment with B vitamins slows the rate of brain atrophy in mild cognitive impairment (MCI)...
  49. pmc Vascular complications of cystathionine β-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research
    Richard S Beard
    Department of Biological Sciences, Idaho State University, Pocatello, Idaho ID 83209 8007, USA
    Am J Physiol Heart Circ Physiol 300:H13-26. 2011
    b>Homocysteine (Hcy), a cardiovascular and neurovascular disease risk factor, is converted to hydrogen sulfide (H(2)S) through the transsulfuration pathway...
  50. pmc Homocysteine induces apoptosis of rat hippocampal neurons by inhibiting 14-3-3ε expression and activating calcineurin
    Jing Wang
    Department of Neurology, Shanghai Tongji University Affiliated Tenth People s Hospital, Shanghai, China
    PLoS ONE 7:e48247. 2012
    A high level of plasma homocysteine (Hcy) increases the risk for neurodegenerative diseases. One such disorder is Alzheimer's disease, which involves marked neuronal apoptosis of unknown etiology...
  51. ncbi Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism?
    M A Pajares
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029, Madrid, Spain
    Cell Mol Life Sci 63:2792-803. 2006
    Betaine homocysteine methyltransferase (BHMT), a Zn(2+)-dependent thiolmethyltransferase, contributes to the regulation of homocysteine levels, increases in which are considered a risk factor for cardiovascular diseases...
  52. ncbi Homocysteine concentrations and molecular analysis in patients with congenital heart defects
    Luciano C Galdieri
    Department of Pediatrics, Universidade Federal de Sao Paulo UNIFESP EPM, Sao Paulo, Brazil
    Arch Med Res 38:212-8. 2007
    Congenital heart defects are the result of incomplete heart development and, like many diseases, have been associated with high homocysteine concentration.
  53. pmc The oxidative stress may be induced by the elevated homocysteine in schizophrenic patients
    Anna Dietrich-Muszalska
    Department of Affective and Psychotic Disorders, Medical University of Lodz, Czechoslowacka 8 10, 92 216, Lodz, Poland
    Neurochem Res 37:1057-62. 2012
    ..In the present study, we investigated the effect of elevated level of homocysteine (Hcys) on some parameters of oxidative stress, namely thiobarbituric acid reactive substances (TBARS), an index ..
  54. ncbi High consumption of Ω-3 polyunsaturated fatty acids decrease plasma homocysteine: a meta-analysis of randomized, placebo-controlled trials
    Tao Huang
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China
    Nutrition 27:863-7. 2011
    ..The objective was to systematically evaluate the effects of ω-3 PUFA supplementation on plasma Hcy levels...
  55. ncbi Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality
    Tao Huang
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310029, PR China
    Clin Nutr 31:448-54. 2012
    ..The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT.
  56. pmc Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease
    Alla V Glushchenko
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Case Western Reserve University, Cleveland, Ohio 44195, USA
    Antioxid Redox Signal 9:1883-98. 2007
    ..That elevated homocysteine leads to vascular dysfunction may be the linking factor between these apparently unrelated pathologies...
  57. ncbi Serum total homocysteine concentrations in adolescent and adult Americans: results from the third National Health and Nutrition Examination Survey
    P F Jacques
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 69:482-9. 1999
    The elevation of circulating total homocysteine concentrations in a fasting state is associated with an increased risk of occlusive vascular disease.
  58. ncbi Cardiology patient pages. Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease
    Elizabeth A Varga
    Department of Internal Medicine, of Human Genetics, The Ohio State University, Columbus, Ohio, USA
    Circulation 111:e289-93. 2005
  59. ncbi Homocysteine and reclassification of cardiovascular disease risk
    Vikas Veeranna
    Division of Cardiology, Wayne State University, Detroit Medical Center, Detroit, MI 48201, USA
    J Am Coll Cardiol 58:1025-33. 2011
    The purpose of this study was to examine whether adding homocysteine (Hcy) to a model based on traditional cardiovascular disease (CVD) risk factors improves risk classification.
  60. pmc Regulation of homocysteine metabolism and methylation in human and mouse tissues
    Natalie C Chen
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad St, MRB, Philadelphia, PA 19140, USA
    FASEB J 24:2804-17. 2010
    Hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Homocysteine (Hcy) metabolism involves multiple enzymes; however, tissue Hcy metabolism and its relevance to methylation remain unknown...
  61. ncbi Diurnal variations of plasma homocysteine, total antioxidant status, and biological markers of muscle injury during repeated sprint: effect on performance and muscle fatigue--a pilot study
    Omar Hammouda
    Research Laboratory, Sport Performance Optimization, National Centre of Medicine and Science in Sport, Tunis, Tunisia
    Chronobiol Int 28:958-67. 2011
    The aim of this study was (i) to evaluate whether homocysteine (Hcy), total antioxidant status (TAS), and biological markers of muscle injury would be affected by time of day (TOD) in football players and (ii) to establish a relationship ..
  62. ncbi Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS
    Yasushi Enokido
    Department of Molecular Geneticsy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    FASEB J 19:1854-6. 2005
    ..suggest that CBS plays a crucial role in the development and maintenance of the CNS and that radial glia/astrocyte dysfunction might be involved in the complex neuropathological features associated with abnormal homocysteine metabolism.
  63. ncbi The role of paraoxonase 1 in the detoxification of homocysteine thiolactone
    Hieronim Jakubowski
    Department of Biochemistry and Biotechnology, University of Life Sciences, Poznan, Poland
    Adv Exp Med Biol 660:113-27. 2010
    The thioester homocysteine (Hcy)-thiolactone, product of an error-editing reaction in protein biosynthesis, forms when Hcy is mistakenly selected by methionyl-tRNA synthetase...
  64. pmc Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?
    Jia Min Zhuo
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Trends Pharmacol Sci 32:562-71. 2011
    ..The hypothesis that homocysteine (Hcy) is a risk factor for AD was initially prompted by the observation that patients with histologically ..
  65. pmc Cystathionine β-synthase and cystathionine γ-lyase double gene transfer ameliorate homocysteine-mediated mesangial inflammation through hydrogen sulfide generation
    Utpal Sen
    Department of Physiology and Biophysics, University of Louisville, KY 40202, USA
    Am J Physiol Cell Physiol 300:C155-63. 2011
    Elevated level of homocysteine (Hcy) induces chronic inflammation in vascular bed, including glomerulus, and promotes glomerulosclerosis...
  66. pmc Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan
    Mohsin Yakub
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    PLoS ONE 5:e11706. 2010
    ..Mean blood Pb and mean plasma homocysteine levels have been reported to be high in Pakistani population...
  67. pmc Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation
    Roman Thaler
    1st Medical Department, Hanusch Hospital, Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Wiener Gebietskrankenkasse and AUVA Trauma Center Meidling, 1140 Vienna, Austria
    J Biol Chem 286:5578-88. 2011
    Elevated homocysteine (Hcys) serum levels represent a risk factor for several chronic pathologies, including cardiovascular disease, atherosclerosis, and chronic renal failure, and affect bone development, quality, and homeostasis...
  68. ncbi Homocysteine and redox signaling
    Cheng Gang Zou
    Biochemistry Department, University of Nebraska, Lincoln, NE 68588, USA
    Antioxid Redox Signal 7:547-59. 2005
    b>Homocysteine is a thiol-containing amino acid that has gained notoriety because its elevation in the plasma is correlated with complex and multifactorial diseases, including cardiovascular diseases, neurodegenerative diseases, and neural ..
  69. pmc Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans
    Anthony A Fryer
    Institute of Science and Technology in Medicine, Keele University School of Medicine, University Hospital of North Staffordshire Stoke on Trent, Staffordshire, UK
    Epigenetics 6:86-94. 2011
    ..analysis of methylation across samples revealed a significant correlation of methylation patterns with plasma homocysteine, LINE-1 methylation and birth weight centile...
  70. ncbi Mechanisms of increased vascular oxidant stress in hyperhomocys-teinemia and its impact on endothelial function
    N Weiss
    Medizinische Poliklinik Innenstadt, Klinikum der Universitat Munchen, Pettenkoferstrasse 8a, D 80336 MUnchen, Germany
    Curr Drug Metab 6:27-36. 2005
    Elevated plasma levels of homocysteine are associated with an increased generation of reactive oxygen species in aortas of hyperhomocysteinemic animals and in endothelial cells...
  71. ncbi Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine
    Ibrahim Murat Bolayirli
    Istanbul University, Cerrahpasa Medical Faculty, Fikret Biyal Central Research Laboratory, Istanbul, Turkey
    Life Sci 81:121-7. 2007
    ..acid reactive substances (TBARS), NO pathway markers, nitric oxide(NO) and asymmetric dimethylarginine (ADMA), homocysteine, and paraoxonase activity (PON1) in rabbits...
  72. pmc Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged > or =60 y in the United States
    Regan L Bailey
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 92:383-9. 2010
    ..Unmetabolized serum folic acid (UMFA) has been detected in adults. Previous research indicates that high folic acid intakes may be associated with risk of cancer...
  73. pmc Biomarkers of vitamin B-12 status in NHANES: a roundtable summary
    Elizabeth A Yetley
    Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892 7517, USA
    Am J Clin Nutr 94:313S-321S. 2011
    ..biomarkers of vitamin B-12 status used in past NHANES--serum vitamin B-12, methylmalonic acid (MMA), and total homocysteine (tHcy)--and discussed the potential utility of measuring holotranscobalamin (holoTC) for future NHANES...
  74. ncbi Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism?
    Amany K Elshorbagy
    Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, United Kingdom
    Am J Clin Nutr 88:738-46. 2008
    ..of cystathionine beta-synthase-deficient homocystinuria and the positive association of plasma total cysteine (tCys) with body mass index (BMI) suggest that total homocysteine (tHcy) and tCys are associated with body composition.
  75. ncbi Development of a new standard reference material: SRM 1955 (homocysteine and folate in human serum)
    Mary B Satterfield
    Analytical Chemistry Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Anal Bioanal Chem 385:612-22. 2006
    Total homocysteine (tHCY) and folate are interrelated biomarkers for arteriosclerosis and coronary heart disease...
  76. ncbi Homocysteine levels in newly admitted schizophrenic patients
    Julia Applebaum
    Beer Sheba Mental Health Center, Stanley Research Center, Ben Gurion University of the Negev, Beersheva, Israel
    J Psychiatr Res 38:413-6. 2004
    We previously found a marked elevation of plasma homocysteine in young male schizophrenic patients in hospital. It seemed important to determine if this finding is already present in newly admitted schizophrenic patients...
  77. ncbi Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity
    Andrew J Roe
    Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Microbiology 148:2215-22. 2002
    ..Measurement of the intracellular concentrations of pathway intermediates revealed that the homocysteine pool is increased dramatically in acetate-treated cells, suggesting that acetate inhibits a biosynthetic step ..
  78. ncbi Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine
    Martha H Stipanuk
    Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
    Annu Rev Nutr 24:539-77. 2004
    Tissue concentrations of both homocysteine (Hcy) and cysteine (Cys) are maintained at low levels by regulated production and efficient removal of these thiols...
  79. ncbi Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis
    J W Muntjewerff
    GGz Nijmegen, Mental Health Institute Nijmegen, Nijmegen, and Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Mol Psychiatry 11:143-9. 2006
    Elevated plasma homocysteine concentration has been suggested as a risk factor for schizophrenia, but the results of epidemiological studies have been inconsistent...
  80. ncbi Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways
    Toshimitsu Suhara
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Osaka, Japan
    Hypertension 43:1208-13. 2004
    ..In this study, we examined the effect of homocysteine (Hcy) on Fas-mediated apoptosis in endothelial cells...
  81. ncbi Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neurodegeneration of cultured cerebellar granule neurones
    Elzbieta Zieminska
    Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, 02 106 Warsaw, Poland
    Neurochem Int 43:481-92. 2003
    ..demonstrate that apart from NMDA receptors, also group I metabotropic glutamate receptors participate in acute homocysteine (Hcy)-induced neurotoxicity in cultured rat cerebellar granule neurones...
  82. ncbi The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease
    Helga Refsum
    Norwegian Institute of Public Health, Oslo, Norway
    J Nutr 136:1731S-1740S. 2006
    The Hordaland Homocysteine Study (HHS) is a population-based study of more than 18,000 men and women in the county of Hordaland in Western Norway. The first investigation (HHS-I) took place in 1992-93, when the subjects were aged 40-67 y...
  83. ncbi Albumin thiolate anion is an intermediate in the formation of albumin-S-S-homocysteine
    S Sengupta
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:30111-7. 2001
    An elevated concentration of plasma total homocysteine is an independent risk factor for cardiovascular disease. Greater than 80% of circulating homocysteine is covalently bound to plasma protein by disulfide bonds...
  84. ncbi N-methyl-D-glucamine improves the laser-induced fluorescence capillary electrophoresis performance in the total plasma thiols measurement
    Angelo Zinellu
    Chair of Clinical Biochemistry, University of Sassari, Viale San Pietro 43 B, I 07100 Sassari, Italy
    Electrophoresis 24:2796-804. 2003
    ..We show that CE-LIF allows a baseline separation of total plasma cysteinylglycine, homocysteine, cysteine, and glutathione in less than 5 min when N-methyl-D-glucamine in run buffer was added...
  85. ncbi Homocysteine and lipids: S-adenosyl methionine as a key intermediate
    Rima Obeid
    Department of Clinical Chemistry and Laboratory Medicine, Central Laboratory, University Hospital, Saarland University, D 66424 Homburg Saar, Germany
    FEBS Lett 583:1215-25. 2009
    ..Higher plasma homocysteine (Hcy) was associated with lower high-density lipoprotein (HDL)-cholesterol level...
  86. ncbi Homocysteine as a predictive factor for hip fracture in older persons
    Robert R McLean
    Hebrew Rehabilitation Center for Aged Research and Training Institute, Boston, USA
    N Engl J Med 350:2042-9. 2004
    The increased prevalence of osteoporosis among people with homocystinuria suggests that a high serum homocysteine concentration may weaken bone by interfering with collagen cross-linking, thereby increasing the risk of osteoporotic ..
  87. ncbi Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
    I I Kruman
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Neurosci 20:6920-6. 2000
    Elevated plasma levels of the sulfur-containing amino acid homocysteine increase the risk for atherosclerosis, stroke, and possibly Alzheimer's disease, but the underlying mechanisms are unknown...
  88. pmc The methylenetetrahydrofolate reductase 677C-->T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism
    Steinar Hustad
    The Hormone Laboratory, Haukeland University Hospital, Bergen, Norway
    Am J Hum Genet 80:846-55. 2007
    ..These B vitamins are essential for the remethylation and transsulfuration of homocysteine, which is an important intermediate in one-carbon metabolism...
  89. ncbi Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians
    H Refsum
    Department of Pharmacology and the Locus for Homocysteine and Related Vitamins, University of Bergen, Norway
    Am J Clin Nutr 74:233-41. 2001
    ..In India, most people adhere to a vegetarian diet, which may lead to cobalamin deficiency...
  90. pmc Training effects of short bouts of stair climbing on cardiorespiratory fitness, blood lipids, and homocysteine in sedentary young women
    C A G Boreham
    Department of Sport and Exercise Science, University of Ulster at Jordanstown, Newtownabbey, Co Antrim, Northern Ireland, UK
    Br J Sports Med 39:590-3. 2005
    To study the training effects of eight weeks of stair climbing on Vo2max, blood lipids, and homocysteine in sedentary, but otherwise healthy young women.
  91. ncbi Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Oxford, UK
    J Inherit Metab Dis 34:83-91. 2011
    Moderately elevated homocysteine levels have been associated with a higher risk of cardiovascular disease in observational studies, but whether these associations are causal is uncertain...
  92. ncbi Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
    P F Jacques
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 73:613-21. 2001
    Established determinants of fasting total homocysteine (tHcy) concentration include folate and vitamin B-12 status, serum creatinine concentration, and renal function.
  93. ncbi Homocysteine enhances bone resorption by stimulation of osteoclast formation and activity through increased intracellular ROS generation
    Jung Min Koh
    Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Songpa Gu, Seoul, Korea
    J Bone Miner Res 21:1003-11. 2006
    ..Physiologic concentrations of Hcy directly activate osteoclast formation and activity through stimulation of p38 MAPK and integrin beta3. The effects of Hcy were mediated by generation of intracellular ROS...
  94. ncbi Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine
    M C Stühlinger
    Section of Vascular Medicine, Stanford University, Stanford, California, USA
    Circulation 104:2569-75. 2001
    ..Accordingly, we determined if homocysteine could increase ADMA levels.
  95. pmc Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:198-206. 2010
    Ambient particles are associated with cardiovascular events and recently with total plasma homocysteine. High total plasma homocysteine is a risk for human health. However, the biologic mechanisms are not fully understood...
  96. ncbi Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease
    Prabath W B Nanayakkara
    Department of Internal Medicine, Institute for Cardiovascular Research, VU University Medical Center, VU University, Amsterdam, The Netherlands
    Nephrol Dial Transplant 23:2586-92. 2008
  97. ncbi Long-term effect of betaine on risk factors associated with the metabolic syndrome in healthy subjects
    U Schwab
    Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
    Eur J Clin Nutr 65:70-6. 2011
    To examine the effects of betaine on serum lipid profile, plasma homocysteine concentration and hemostatic factors in healthy subjects.
  98. ncbi Homocysteine, glycine betaine, and N,N-dimethylglycine in patients attending a lipid clinic
    Michael Lever
    Biochemistry Unit, Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand
    Metabolism 54:1-14. 2005
    ..The relationships between homocysteine and plasma and urinary glycine betaine were highly significant (P < ...
  99. ncbi Effect of homocysteinylation on high density lipoprotein physico-chemical properties
    Gianna Ferretti
    Dipartimento di Biochimica, Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri, 60131 Ancona, Italy
    Chem Phys Lipids 163:228-35. 2010
    ..and could contribute to accelerated atherosclerosis in patients affected by diseases associated with oxidative damage, in renal disorders and in patients affected by genetic or nutritional disorders of homocysteine or folate metabolism.
  100. pmc Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population
    Mohsin Yakub
    Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan
    PLoS ONE 7:e33222. 2012
    ..A1298C), methionine synthase (MS; A2756G), cystathionine-β-synthase (CBS; T833C/844ins68, G919A) involved in homocysteine metabolism and investigated their interactions with nutritional and environmental factors in a Pakistani ..
  101. pmc Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis
    Xianhui Qin
    Institute of Biomedicine, Anhui Medical University, Hefei, China
    Clin J Am Soc Nephrol 6:482-8. 2011
    The efficacy of folic acid therapy to lower homocysteine (Hcy) levels in an effort to reduce cardiovascular disease (CVD) risk in patients with ESRD or advanced chronic kidney disease (ACKD; creatinine clearance, <30 ml/min) remains ..

Research Grants76

  1. B12 Nutrition in the Aged
    Sally Stabler; Fiscal Year: 2007
    Hyperhomocysteinemia (high serum total homocysteine) remains a problem for seniors even in this era of highly folate-fortified food in the United States...
  2. Cystathionine beta synthase (CBS) and angiogenesis
    Priyabrata Mukherjee; Fiscal Year: 2013
    ..the pro-angiogenic effect either directly or indirectly by maintaining an intricate balance among cellular homocysteine (Hcy), glutathione (GSH) and hydrogen sulfide (H2S) levels...
  3. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..to assess the role of methyl groups - S-adenosylmethionine, S-adenosylhomocysteine, methionine, choline, homocysteine, folate, vitamins B6 and B12 in the development of liver cancer;(4) to assess the role of genetic polymorphisms ..
  4. Maternal One Carbon Metabolism and Low Birth Weight Infant
    Satish C Kalhan; Fiscal Year: 2013
    ..The specific aims are to longitudinally document maternal methionine, homocysteine metabolism, relate it to nutrient (protein) intake, folate, B12, pyridoxine status, and measures of insulin ..
  5. Vitamin B6 Effects on One-Carbon Metabolism
    Jesse F Gregory; Fiscal Year: 2013
    ..The mechanisms responsible are unknown, but the risk largely is independent of plasma homocysteine concentration...
    Steven G Clarke; Fiscal Year: 2013
    ..interested in identifying potential novel sites of methyltransferase inhibition associated with elevated plasma homocysteine levels in humans that have been linked to cardiovascular and neurological diseases...
  7. IGF-1, bone turnover and response to teriparatide in premenopausal women with IOP
    Adi Cohen; Fiscal Year: 2013
    ..LDL) cholesterol and cardiovascular risk markers such as C-reactive protein (CRP), interleukin-6 (IL-6) and homocysteine. The goals of this pilot study are to determine whether premenopausal women with IOP and low bone formation ..
  8. Homocysteine and Angiotensin II in Renovascular Remodeling
    Utpal Sen; Fiscal Year: 2013
    ..provided by applicant): Although it is not clear whether hyperhomocysteinemia (HHcy), an elevated plasma homocysteine (Hcy) level, causes hypertension, recent clinical data suggest an association between systolic hypertension and ..
  9. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ..Preconception BMI and Micronutrients: including serum biomarkers of folate, B6, B12, cysteine, homocysteine, hemoglobin, ferritin, and trans-ferritin receptor, TfR;and (4) Preconception Exposure: including serum DDT/DDE,..
  10. Microvascular Dysfunction in Hyperhomocysteinemia
    Shawn E Bearden; Fiscal Year: 2012
    ..Little is known of how disease alters CVD within a microvascular network. Elevated blood concentration of homocysteine (hyperhomocysteinemia;HHcy) is a risk factor for several cardiovascular diseases...
    Richard C Deth; Fiscal Year: 2012
    ..changes of intracellular thiols (reduced and oxidized forms of glutathione (GSH and GSSG), cysteine and homocysteine) as well as methylation-related metabolites methionine, S- adenosylmethionine (SAM), S-adenosylhomocysteine (..
    HYUNG D RYOO; Fiscal Year: 2010
    ..this equilibrium, occurs during hypoxia, nutrient deprivation or exposure to endogenous toxins such as homocysteine. ER stress is also likely to occur in secretory cells handling heavy client protein loads, such as 13cells in ..
  13. Genetic Risk for Orofacial Clefts in the Folate/Homocysteine Pathway
    NICHOLAS MARINI; Fiscal Year: 2013
    ..To test this hypothesis, we will sequence the coding regions in all folate/homocysteine pathway genes (N=32) from a population of ~375 cleft-affected infants and ~375 controls...
  14. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2012
    ..will obtain measurements on additional peripheral vascular markers (glycosylated hemoglobin, Apo A1, ApoB, homocysteine, C-Reactive Protein, and cystatin) from subgroups of participants with normal cognition and with subtypes of ..
  15. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2012
    ..metabolism (total folate, unmetabolized folic acid, 5-methyl-tetrahydrofolate, vitamins B6 and B12, cysteine, homocysteine, and methylene-tetrahydrofolate reductase gene) and genomic DNA methylation, to determine the role of each ..
  16. Role of homocysteine in retinal disease
    Sylvia B Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goal of this project is to determine how elevated levels of homocysteine (Hcy) (hyperhomocysteinemia, HHcy)) contribute to retinal neurovascular disease...
  17. Mammalian Mitochondrial One-Carbon Metabolism
    DEAN RAMSAY APPLING; Fiscal Year: 2010
    ..This is reflected in human diseases associated with folate and homocysteine metabolism (e.g...
  18. Homocysteine, Adiponectin, and Alcoholic Liver Disease
    Zhenyuan Song; Fiscal Year: 2013
    ..Abnormal hepatic methionine/homocysteine metabolism and hyperhomocysteinemia induced by prolonged alcohol exposure has been reported both in clinical ..
    Jeffrey C Murray; Fiscal Year: 2013
    ..of the R37 This R37 is the parent for Dr Felix's F32 Fogarty Award where she is investigating folate and homocysteine levels in mothers of children with clefts in Brazil...
  20. Redox Triggering of Glomerular NALP3 Inflammasomes in Hyperhomocysteinemia
    Justine M Abais; Fiscal Year: 2013
    ..While there are many factors contributing to elevated plasma homocysteine (Hcys) such as sex, genetics, and kidney function, age itself is a major contributor, where upwards of 30% of ..
  21. Exercise and H2S mitigate homocysteine-mediated beta2-adrenergic receptor dysfunc
    Paras Kumar Mishra; Fiscal Year: 2013
    ..Elevated level of homocysteine (Hcy) called hyperhomocysteinemia (HHcy, a co-morbid condition) is associated with heart failure in diabetes...
  22. Selenium, other risk factors and cognitive decline in rural elderly Chinese
    Sujuan Gao; Fiscal Year: 2013
    ..to collect blood samples from all study participants in order to obtain biomarker measures including lipids, homocysteine, insulin, glucose, interleukin-6 levels as well as other trace element levels including calcium, cadmium and ..
  23. Epidemiology of Biomarkers of Risk and Progression in LOAD
    Nicole Schupf; Fiscal Year: 2013
    ..and selected biomarkers in this elderly, multi-ethnic cohort, including lipids, amyloid peptides, sex hormones, homocysteine, insulin and C-reactive protein (CRP), and MRI...
  24. Effects of Yoga on CVD Risk Factors among African Americans: Jackson Heart Study
    Gailen D Marshall; Fiscal Year: 2013
    ..will be changes in participants'systolic and diastolic blood pressure and their levels of CRP, fibrinogen, homocysteine, and interleukin-6...
  25. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia M Ulrich; Fiscal Year: 2012
    ..obtained at the baseline visit include vitamin B12, holo-transcobalamin II, pyridoxalphosphate (vitamin B6), homocysteine, serum and RBC folate, and global lymphocyte DNA methylation...
  26. Prevalence of environmental and genetic risk factors for gastric cancer in a popu
    LOVELL ALLAN JONES; Fiscal Year: 2011
    ..3: Determine the folate, vitamin B-12 and homocysteine levels of the children...
  27. Alcohol-Induced Fatty Liver and Injury in Humanized CYP2E1 Knockin Mice.
    Arthur I Cederbaum; Fiscal Year: 2011
    ..We propose that such downstream mediators from CYP2E1 in association with ethanol-induced elevation of TNF1, homocysteine and ER stress activate lipogenic transcription factors and enzymes while decreasing activation of lipolytic ..
  28. Hyperhomocysteinemia, S-adenosylhomocysteine Accumulation, and Epigenetics
    Warren D Kruger; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Elevated levels of plasma total homocysteine (tHcy), termed hyperhomocysteinemia (HHcy), are associated prospectively with increased incidence and mortality of many human diseases including coronary ..
  29. Parenteral Methionine Requirements in Septic Children
    Leticia Castillo; Fiscal Year: 2013
    ..acid intakes, GSH synthesis rates and methyl group availability defined by the adenosyl- methionine/adenosyl-homocysteine ratio...
  30. Homocysteine: Vascular Biochemistry and Metabolism
    DONALD WELDON JACOBSEN; Fiscal Year: 2010
    ..b>Homocysteine-induced endothelial cell dysfunction may link this diverse group of pathologies...
  31. Prev. of Cardiovas. Complications of Pediatric SLE: Artherosclerosis Prev in Pedi
    Laura E Schanberg; Fiscal Year: 2009
    ..Cardiovascular-specific outcome measures will include assessments of high sensitivity CRP;fasting lipid profile;homocysteine level;apolipoprotein A, B1, and Lp(a);carotid intima media thickness (IMT);and tensor diffusion/MRI...
  32. Atherogenic Mechanisms Associated with Hyperhomocysteinemia
    Hong Wang; Fiscal Year: 2013
    ..In Aim 3, we will study the effect of homocysteine-lowering on preventing MC trans-endothelium migration into the vessel wall and on reducing spontaneous ..
  33. Mechanisms of Mitochondrial Dysfunction in Brain Vasculature
    Neetu Tyagi; Fiscal Year: 2013
    ..HHcy is generated due to increase in de-methylation of methionine by S-adenosine- homocysteine hydrolase (SAHH) and a decrease in methyltetrahydrofolate reductase (MTHFR) and cystathionine-y-lyase (CSE, an ..
  34. Molecular basis of homocysteine-glutamate receptor mediated neuronal cell death
    Ranjana Poddar; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Elevated plasma level of homocysteine (hyper-homocysteinemia) is a major risk factor for neurodegenerative disorders...
    MARTIN CONRAD CAREY; Fiscal Year: 2013
    ..Elevation of plasma and bile homocysteine, a by-product of this reaction, may serve as a lithogenic marker and shed light on vicinal and distal organ ..
  36. Homocysteine, ER Stress and Alcoholic Liver Injury.
    Neil Kaplowitz; Fiscal Year: 2013
    ..our previous studies we have developed five specific aims which test the hypothesis that ER stress induced by homocysteine plays a key role in the pathogenesis of alcoholic liver disease: Aim 1...
  37. Stable isotope evaluation of the methionine cycle in undernourished pregnancy
    Peter W Nathanielsz; Fiscal Year: 2013
    ..Impaired methyl transfers have structural and metabolic consequences e.g. neural tube defects and high homocysteine (HCYS). Gene methylation is a fundamental mechanism leading to persistent epigenetic changes...
  38. Hyperhomocysteinemia and HDL Metabolism
    Hong Wang; Fiscal Year: 2013
    ..severe HHcy models with double gene deficiency for Cystathionine [unreadable]-synthase (CBS) which degrade homocysteine (Hcy), and either apolipoprotein E (ApoE) or low density lipoprotein receptor (LDLR), and with an inducible ..
  39. Mechanisms of Sensitization to TNF hepatotoxicity in ALD
    Zhenyuan Song; Fiscal Year: 2009
    ..Whereas alcohol consumption causes hepatic deficiency of S-adenosylmethionie (SAMe), it elevates hepatic homocysteine levels, a product of SAMe metabolism...
  40. The Effects of Reactive Oxygen Species on Endothelial Progenitor Cells
    Jalees Rehman; Fiscal Year: 2010
    ..Our preliminary data demonstrates that EPCs are sensitive to ROS generated by hydrogen peroxide as well as homocysteine, but it is not known which mechanisms mediate the effects in EPCs or how ROS affect the function of EPCs in ..
  41. Ginsenoside Rb1 Decreases Injury-Induced Vascular Restenosis
    Wei Zhou; Fiscal Year: 2010
    ..We recently have demonstrated that ginsenoside Rb1 (Rb1) blocks homocysteine (HCY)-induced detrimental effects on endothelial vasomotor function, free-radical production, and eNOS ..
  42. The Role of Transmethylation Reactions in Autoimmunity
    BRIAN RANDOLPH LAWSON; Fiscal Year: 2012
    ..of this, we have specifically documented in published and preliminary studies that inhibition of S-adenosyl-L-homocysteine hydrolase (SAHase), a major enzyme involved in transmethylation, leads to immunosuppression by reducing ..
  43. Novel Risk Factors For Hypertension
    John P Forman; Fiscal Year: 2010
    ..B vitamins, and methionine can influence endothelial function either directly or through effects on circulating homocysteine (Hey), we hypothesize that higher intakes of folate, vitamin B6, and vitamin B12 will reduce the risk of ..
  44. Wilson Disease: Regulation of Steatosis by Methionine Metabolism
    Valentina Medici; Fiscal Year: 2013
    ..of the hepatic S-adenosylmethionine (SAM):SAH ratio, a marker of methylation status, and later time-dependent homocysteine increase...
  45. HHcy-induced Bax upregulation, Treg apoptosis and vascular disease
    Xiao Feng Yang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Elevated level of plasma homocysteine (Hcy), termed hyperhomocysteinemia (HHcy), is an independent risk factor for human coronary heart disease (CHD) and stroke...
  46. Biomarkers of Methionine Metabolism and Risk for Colorectal Adenoma
    Martha J Shrubsole; Fiscal Year: 2010
    ..S-adenosylhomocysteine (SAH), the precursor to homocysteine, has been proposed as a more sensitive marker of alterations in methionine metabolism than homocysteine...
  47. Vascular Risk and Cognition in a Multi-ethnic Cohort
    Clinton B Wright; Fiscal Year: 2013
    ..blood pressure, diabetes, insulin resistance and the metabolic syndrome, reported alcohol consumption, total homocysteine and inflammatory markers;and 2) To determine if cerebrovascular brain damage as measured by quantitative MRI, ..
  48. Conotruncal defects: genetic and nutritional risk
    EDWARD JAMES LAMMER; Fiscal Year: 2010
    ..variation of five genes related to folate metabolic pathways (5,10-methyltetrahydrofolate reductase, betaine homocysteine methyltransferases 1&2, N-acetyltransferase 1, and thymidylate synthase);2) studying genetic variation of ..
  49. Mechanisms of Homocysteine-Induced Fibrinogen-Amyloid Plaque Formation
    Suresh C Tyagi; Fiscal Year: 2013
    ..Although a strong association between Ab, fibrinogen (Fg), and elevated level of homocysteine (Hcy), i.e...
  50. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2009
    ..that the mechanism for protection by these micronutrients may be through reduction in the accumulation of homocysteine. In addition, we found that intake of antioxidant nutrients and dietary fat composition may be important in the ..
  51. Southern California Research Center for ALPD and Cirrhosis
    Hidekazu Tsukamoto; Fiscal Year: 2013
    ..molecular targets for ALPD including: mitochondrial free cholesterol causing hepatic sensitization to TNFa;homocysteine inducing ER stress in hepatocytes;the regulatory 13 subunit of methionine adenosyltransferase promoting ..
  52. Homocysteine &Heme: A Role in Thrombosis?
    Jan P Kraus; Fiscal Year: 2012
    ..Positioned at a branch point in sulfur metabolism, CBS is the only enzyme that irreversibly removes toxic homocysteine from the body...
  53. Biodemography of Health, Social Factors and Life Challenge
    Noreen Goldman; Fiscal Year: 2012
    ..These assessments will be added to the public use data set. 2) We will perform assays (5-HTTLPR, homocysteine, folate, ICAM-1, e-selectin, and high sensitivity C-reactive protein) of frozen round 1 blood specimens to "..
  54. Sulfur stress in Salmonella enterica
    Lawrence J Reitzer; Fiscal Year: 2010
    ..with bacterial model systems could provide insight into other problems, such as heart disease, since homocysteine is an independent risk factor for heart disease, and the chemistry of cysteine- and homocysteine- mediated ..
  55. Nutrition and Oral Clefts in Asia: Planning Grant
    Ronald G Munger; Fiscal Year: 2010
    ..Maternal biomarkers related to one-carbon metabolism (1-CM) including folate, zinc, vitamin B-6, and homocysteine have been associated with risk of oral clefts- but several inconsistencies require clarification before public ..
  56. A platform for individualized nutritional therapy in Alzheimer's disease
    Gene L Bowman; Fiscal Year: 2012
    ..The nutrient parameters to be studied include homocysteine and its determinants, antioxidants and F2 Isoprostanes as a marker of oxidative stress, the omega 3 fatty acids ..
  57. Perioperative pharmacogenetics: Nitrous oxide and anesthetic outcomes
    Peter Nagele; Fiscal Year: 2013
    ..Nitrous oxide is the most commonly used general anesthetic in the world. It inhibits vitamin 812 and increase homocysteine concentrations. Chronic homocysteinemia has been associated with adverse cardiac events...
  58. Protein Acylation and Methylation Mechanisms
    Philip A Cole; Fiscal Year: 2013
    ..3. Clarify the effects of Lys acetylation on S-adenosyl homocysteine hydrolase and inositol monophosphate dehydrogenase-2...
  59. Oral cleft prevention program
    Jeffrey C Murray; Fiscal Year: 2010
    ..Under separate funding we will also examine the role of genes involved in folate metabolism on folate, B12 and homocysteine levels...
  60. Mediterranean Diet and Other Dietary Patterns in Alzheimer's Disease
    NIKOLAOS A SCARMEAS; Fiscal Year: 2012
    ..inflammatory (C-reactive protein, interleukin-6, interleukin-1), metabolic (insulin, adiponectin) and vascular (homocysteine, MRI white matter hyperintensities and MRI subclinical infarcts) pathways in order to gain further insight into ..
  61. Pathways of fenofibrate effects on cardiovascular outcomes in ACCORD
    Henry N Ginsberg; Fiscal Year: 2013
    ..particle number, VLDL composition, including lipidomic profiling of VLDL TG fatty acids, fibrinogen, CRP, and homocysteine. Specifically we will 1) determine the ability of these biomarkers to predict the occurrence of CVD in a sub-..
  62. Neural Correlates and Modifiers of Cognitive Aging
    Naftali Raz; Fiscal Year: 2013
    ..of sub-clinical levels of vascular risk conveyed by elevated blood pressure, circulating cardiac risk factors (homocysteine, C-reactive protein), elevated insulin, and genetic variants associated with vascular and metabolic risk (MTHFR ..
  63. 5Lipoxygenase-mediated vasculopathy in HHcy
    Domenico Pratico; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Elevated levels of total plasma homocysteine (Hcy), termed hyperhomocysteinemia (HHcy), are associated with increased incidence and mortality of chronic vascular diseases including coronary heart ..
  64. Folic Acid and B Vitamins to Prevent Fracture in Women
    Steven Cummings; Fiscal Year: 2009
    ..Prospective studies have found that women with elevated plasma homocysteine have a substantially increased risk of osteoporotic fractures, including hip fractures...
  65. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    Numerous studies have demonstrated that homocysteine (HCY) is a major risk factor in heart disease and stroke...
    MARK STEEN; Fiscal Year: 2001
    Adapted from the applicant's abstract): Moderate elevations of total plasma homocysteine (tHcy) are risk-factors for premature thrombovascular disease (PVD) and neural-tube defects (NTD)...
  67. Homocysteine's role in the causation of presbyopia
    CHARLES PRINCE; Fiscal Year: 2002
    Elevated circulating homocysteine is the major biochemical feature of cystathionine beta-synthase deficiency (also known as homocystinuria) with total plasma levels usually exceeding 100microM (normal total plasma levels do not exceed ..
    Warren Kruger; Fiscal Year: 2009
    Elevations in plasma homocysteine levels are associated with an increased risk of a number of human diseases including vascular disease, neural tube defects, age-related dementia, and osteoporoticfractures...
    JESSE GREGORY; Fiscal Year: 2004
    ..of carbon units for use in cellular processes including DNA synthesis, regeneration of methionine (Met) from homocysteine (Hcy), and methylation of many biological compounds. Conditions that impair one-carbon metabolism (e.g...
  70. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    In the past years, two independent case control studies have established a correlation between elevated homocysteine levels and Alzheimer's Disease (AD)...
  71. Folate, Smoking, Race and Cervical Cancer Risk
    Capri Mara Fillmore; Fiscal Year: 2004
    ..By improving study design, increasing sample size, utilizing dietary folate equivalents (DFEs) and homocysteine levels (a functional marker of folate sufficiency) in assessing these inter-relationships, and sub-group ..
    Shelly Lu; Fiscal Year: 2005
    ..In the liver, this was associated with decreased SAM level and global DNA hypomethylation. Second, homocysteine in pathologically relevant concentrations induced the expression of tissue inhibitor of metalloproteinases-4 (..
  73. CVD Mechanisms Associated with Phytoestrogens Use
    Donna Kritz Silverstein; Fiscal Year: 2003
    ..Potential mechanisms include changes in homocysteine metabolism, inhibition in markers of inflammatory activity including interleukin-6 (IL- 6) and C-reactive ..
  74. AdoHcy Hydrolase Inhibitors as Antiparasitic Agents
    RONALD BORCHARDT; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): S-Adenosyl-L-homocysteine (AdoHcy) hydrolase (EC 3 3 1 1) in mammalian cells and certain parasites [e.g...
  75. Selenium, Glutathione Peroxidase-1, and Homocysteine-induced Cardiac Remodeling
    Jacob Joseph; Fiscal Year: 2009
    ..Based on our preliminary observations, homocysteine decreases GPx-1 activity and increases oxidant stress and collagen secretion in cultured cardiac fibroblasts, ..
  76. Kinetics of Human Homocysteine Metabolism
    Glen Duncan; Fiscal Year: 2004
    ..the hypothesis that type II diabetes (DM2) patients with poor glycemic control have higher levels of basal homocysteine (Hcy) due to impaired Hcy metabolism...