Summary: Substances that comprise all matter. Each element is made up of atoms that are identical in number of electrons and protons and in nuclear charge, but may differ in mass or number of neutrons.

Top Publications

  1. ncbi Atmospheric deposition of trace element pollutants in Macedonia studied by the moss biomonitoring technique
    L Barandovski
    Sts Cyril and Methodius University, Faculty of Sciences, POB 162, 1000, Skopje, Macedonia
    Environ Monit Assess 138:107-18. 2008
  2. ncbi Beyond macronutrients: element variability and multielement stoichiometry in freshwater invertebrates
    Roxanne Karimi
    Ecol Lett 9:1273-83. 2006
  3. doi Biofortification of crops with seven mineral elements often lacking in human diets--iron, zinc, copper, calcium, magnesium, selenium and iodine
    Philip J White
    The Scottish Crop Research Institute, Invergowrie, Dundee, UK
    New Phytol 182:49-84. 2009
  4. pmc Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81
    Nicholas J Croucher
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, Cambridgeshire, United Kingdom
    J Bacteriol 191:1480-9. 2009
  5. pmc Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements
    James J P Stewart
    Stewart Computational Chemistry, 15210 Paddington Circle, Colorado Springs, CO 80921, USA
    J Mol Model 13:1173-213. 2007
  6. ncbi Assessment of reference values for selected elements in a healthy urban population
    Alessandro Alimonti
    Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 41:181-7. 2005
  7. doi Applications of synchrotron μ-XRF to study the distribution of biologically important elements in different environmental matrices: a review
    Sanghamitra Majumdar
    Chemistry Department, The University of Texas at El Paso, El Paso, TX 79968, USA
    Anal Chim Acta 755:1-16. 2012
  8. ncbi X-ray microanalysis of elements in the masticatory muscle after paresis of the right masseter
    T Gedrange
    Department of Orthodontics, School of Dentistry, Medical Faculty, Carl Gustav Carus Technical University of Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    J Dent Res 84:1026-30. 2005
  9. doi Reference values of elements in human hair: a systematic review
    Marcin Mikulewicz
    Department of Dentofacial Orthopeadics and Orthodontics, Medical University of Wrocław, Poland Electronic address
    Environ Toxicol Pharmacol 36:1077-86. 2013
  10. doi Trace and major elements status in bronchoalveolar lavage fluid in dogs with or without bronchopneumonia
    Kazuyuki Suzuki
    Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Biol Trace Elem Res 124:92-6. 2008

Detail Information

Publications352 found, 100 shown here

  1. ncbi Atmospheric deposition of trace element pollutants in Macedonia studied by the moss biomonitoring technique
    L Barandovski
    Sts Cyril and Methodius University, Faculty of Sciences, POB 162, 1000, Skopje, Macedonia
    Environ Monit Assess 138:107-18. 2008
    ..were collected in September-October 2002 at 73 sites evenly distributed over the country, and a total of 43 elements were determined by instrumental neutron activation analysis and atomic absorption spectrometry...
  2. ncbi Beyond macronutrients: element variability and multielement stoichiometry in freshwater invertebrates
    Roxanne Karimi
    Ecol Lett 9:1273-83. 2006
    ..We predicted that somatic concentrations of tightly regulated elements would be less variable than weakly and unregulated elements...
  3. doi Biofortification of crops with seven mineral elements often lacking in human diets--iron, zinc, copper, calcium, magnesium, selenium and iodine
    Philip J White
    The Scottish Crop Research Institute, Invergowrie, Dundee, UK
    New Phytol 182:49-84. 2009
    The diets of over two-thirds of the world's population lack one or more essential mineral elements. This can be remedied through dietary diversification, mineral supplementation, food fortification, or increasing the concentrations and/or ..
  4. pmc Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81
    Nicholas J Croucher
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, Cambridgeshire, United Kingdom
    J Bacteriol 191:1480-9. 2009
    ..strain, and comparison with other available genomes, indicates roles for integrative and conjugative elements in the evolution of pneumococci and, more particularly, the emergence of the multidrug-resistant Spain 23F ST81 ..
  5. pmc Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements
    James J P Stewart
    Stewart Computational Chemistry, 15210 Paddington Circle, Colorado Springs, CO 80921, USA
    J Mol Model 13:1173-213. 2007
    ..These changes have resulted in a more complete parameter optimization, called PM6, which has, in turn, allowed 70 elements to be parameterized...
  6. ncbi Assessment of reference values for selected elements in a healthy urban population
    Alessandro Alimonti
    Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 41:181-7. 2005
    Reference values for 26 elements, namely Al, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Ni, Pb, Sb, Si, Sn, Sr, Tl, V, W, Zn and Zr are proposed in serum and blood of 110 healthy adults of the urban area of Rome...
  7. doi Applications of synchrotron μ-XRF to study the distribution of biologically important elements in different environmental matrices: a review
    Sanghamitra Majumdar
    Chemistry Department, The University of Texas at El Paso, El Paso, TX 79968, USA
    Anal Chim Acta 755:1-16. 2012
    ..including soils, sediments, and living organisms are reservoirs of several essential as well as non-essential elements. Accurate qualitative and quantitative information on the distribution and interaction of biologically ..
  8. ncbi X-ray microanalysis of elements in the masticatory muscle after paresis of the right masseter
    T Gedrange
    Department of Orthodontics, School of Dentistry, Medical Faculty, Carl Gustav Carus Technical University of Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    J Dent Res 84:1026-30. 2005
    ..Botox((R)) has an indirect impact on ion concentrations, resulting in changes in muscle functional capacity and adaptive compensation of paretic muscle function by other muscles...
  9. doi Reference values of elements in human hair: a systematic review
    Marcin Mikulewicz
    Department of Dentofacial Orthopeadics and Orthodontics, Medical University of Wrocław, Poland Electronic address
    Environ Toxicol Pharmacol 36:1077-86. 2013
    The lack of systematic review on reference values of elements in human hair with the consideration of methodological approach...
  10. doi Trace and major elements status in bronchoalveolar lavage fluid in dogs with or without bronchopneumonia
    Kazuyuki Suzuki
    Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Biol Trace Elem Res 124:92-6. 2008
    ..study was to investigate the relationships between the bronchopneumonia and mean concentrations of those trace elements in bronchoalveolar lavage fluid (BALF)...
  11. ncbi RM1: a reparameterization of AM1 for H, C, N, O, P, S, F, Cl, Br, and I
    Gerd B Rocha
    Departamento de Quimica Fundamental, CCEN, UFPE, 50590 470, Recife PE, Brazil
    J Comput Chem 27:1101-11. 2006
    ..Considering that the vast majority of molecules of importance to life can be assembled by using only six elements: C, H, N, O, P, and S, and that by adding the halogens we can now build most molecules of importance to ..
  12. ncbi Trace elements in agroecosystems and impacts on the environment
    Zhenli L He
    MOE Key Lab, Environment Remediation and Ecosystem Health, College of Natural Resources and Environmental Sciences, China Zhejiang University, Huajiachi Campus, Hangzhou 310029, China
    J Trace Elem Med Biol 19:125-40. 2005
    Trace elements mean elements present at low concentrations (mg kg-1 or less) in agroecosystems...
  13. doi Ionomics: The functional genomics of elements
    Ivan Baxter
    Research Computational Biologist, USDA ARS Plant Genetics, Donald Danforth Plant Sciences Center, St Louis, MO 63132, USA
    Brief Funct Genomics 9:149-56. 2010
    ..In this review, I will discuss some of the advantages and limitations of the ionomics approach as well as the important parameters to consider when designing ionomics experiments, and how to evaluate ionomics data...
  14. ncbi Dietary exposure estimates of 18 elements from the 1st French Total Diet Study
    Jean Charles Leblanc
    Institut National de Recherche Agronomique, Unité de recherche INAP G, 16, rue Claude Bernard, 75005 Paris, France
    Food Addit Contam 22:624-41. 2005
    To estimate the dietary exposure of the main minerals and trace elements from retail food typically consumed by the French population, samples were purchased and then prepared and cooked prior to analysis...
  15. pmc Synchrotron radiation X-ray microfluorescence reveals polarized distribution of atomic elements during differentiation of pluripotent stem cells
    Simone C Cardoso
    Instituto de Fisica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 6:e29244. 2011
    ..this work, we characterized the pluripotent state towards neural differentiated state through analysis of trace elements distribution using the Synchrotron Radiation X-ray Fluorescence Spectroscopy...
  16. ncbi Transfer of selected elements from food into human milk
    Olaf Wappelhorst
    International Graduate School of Zittau, Martk 23, D 02763 Zittau, Germany
    Nutrition 18:316-22. 2002
    ..We measured the transfer factors of antimony, cerium, chromium, cobalt, gallium, lanthanum, molybdenum, niobium, ruthenium, silver, thorium, titanium, and uranium from food to milk in nursing mothers...
  17. ncbi Elemental and redox analysis of single bacterial cells by x-ray microbeam analysis
    Kenneth M Kemner
    Environmental Research Division and Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439 4843, USA
    Science 306:686-7. 2004
    ..This technology can be applied to natural geomicrobiological systems...
  18. ncbi Effects of rare earth elements on telomerase activity and apoptosis of human peripheral blood mononuclear cells
    Li Yu
    Key Laboratory of Molecular Medicine and Department of Hematology, Second Affiliated Hospital, Nanchang University, China
    Biol Trace Elem Res 116:53-9. 2007
    ..The blood contents of 15 rare earth elements, including La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and Y, were measured by inductively coupled ..
  19. ncbi Population-based dietary intakes and tap water concentrations for selected elements in the EPA region V National Human Exposure Assessment Survey (NHEXAS)
    K W Thomas
    Research Triangle Institute, Research Triangle Park, North Carolina, USA
    J Expo Anal Environ Epidemiol 9:402-13. 1999
    ..Protection Agency (EPA) Region V, providing population-based exposure distribution data for selected elements in several personal, environmental, and biological media...
  20. ncbi Age-related changes in the concentrations of major and trace elements in the brain of rats and mice
    S Takahashi
    Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Biol Trace Elem Res 80:145-58. 2001
    Age-related changes in the concentrations of constituent elements in the brains of rats and mice 1 wk to 24 mo old were determined with inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission ..
  21. ncbi Determination of 30 elements in colorectal biopsies by sector field inductively coupled plasma mass spectrometry: method development and preliminary baseline levels
    Beatrice Bocca
    Istituto Superiore di Sanita, Department of Environment and Primary Prevention, Viale Regina Elena 299, 00161 Rome, Italy
    Rapid Commun Mass Spectrom 21:1776-82. 2007
    ..procedure applicable to restricted sample sizes was developed and applied to the analysis of 30 chemical elements in colorectal biopsies of healthy patients...
  22. doi Age-related changes of elements in the coronary arteries of monkeys in comparison with those of humans
    Yoshiyuki Tohno
    Laboratory of Cell Biology, Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara, 634 8521, Japan
    Biol Trace Elem Res 125:141-53. 2008
    ..compositional changes of the coronary artery with aging, the authors investigated age-related changes of elements in the coronary arteries of rhesus and Japanese monkeys by direct chemical analysis in comparison with the ..
  23. doi Use of field-portable XRF analyzers for rapid screening of toxic elements in FDA-regulated products
    Peter T Palmer
    Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California 94132, USA
    J Agric Food Chem 57:2605-13. 2009
    ..However, their use in the analysis of toxic elements in food, food ingredients, dietary supplements, and medicinal and herbal products, especially within the FDA and ..
  24. doi Multivariate analysis of elements content of Larch Bolete (Suillus grevillei) mushroom
    Krzysztof Chudzyński
    University of Gdansk, Department of Environmental Chemistry, Ecotoxicology and Food Toxicology, 18 Sobieskiego Str, PL 80 952 Gdansk, Poland
    Chemosphere 73:1230-9. 2008
    ..Amongst these elements Rb and K were highly bioconcentrated by Larch Bolete (BCF around 1000 and 300 for the caps), and weaker were Cu, ..
  25. ncbi Revisiting the plant hyperaccumulation criteria to rare plants and earth abundant elements
    Cristina Branquinho
    Universidade de Lisboa, Faculdade de Ciencias, Centro de Ecologia e Biologia Vegetal, Campo Grande C2, Piso 4, 1749 016 Lisboa, Portugal
    Environ Pollut 146:437-43. 2007
    ..the several criteria of a hyperaccumulator plant in order to include rare and endemic ones and abundant elements. In ecological terms, the enrichment in Al and Fe observed may account for the differences in the vegetation ..
  26. ncbi The natural selection of the chemical elements
    R J Williams
    Inorganic Chemistry Laboratory, University of Oxford, UK
    Cell Mol Life Sci 53:816-29. 1997
    ..life, and then its evolution as the environment forced the DNA into novel development by introducing chemical elements in new forms. The situation today is no different...
  27. ncbi Serum chemical elements and oxidative status in Alzheimer's disease, Parkinson disease and multiple sclerosis
    Alessandro Alimonti
    Department of the Environment and Primary Prevention, Istituto Superiore di Sanita, Viale Regine Elena 299, 00161 Rome, Italy
    Neurotoxicology 28:450-6. 2007
    The role of some chemical elements in neurodegeneration was suggested by various authors. To obtain a profile of chemical elements and oxidative status in complex neurological diseases, an unbiased "omics" approach, i.e...
  28. ncbi Distinguishing between natural and anthropogenic sources for elements in the environment: regional geochemical surveys versus enrichment factors
    Clemens Reimann
    Geological Survey of Norway, N 7491 Trondheim, Norway
    Sci Total Environ 337:91-107. 2005
    ..enrichment factors (EFs) are commonly used in the literature to support the hypothesis that a particular suite of elements is of anthropogenic origin...
  29. pmc Accumulation of biomass and mineral elements with calendar time by corn: application of the expanded growth model
    Allen R Overman
    Agricultural and Biological Engineering Department, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 6:e28515. 2011
    The expanded growth model is developed to describe accumulation of plant biomass (Mg ha(-1)) and mineral elements (kg ha(-1)) in with calendar time (wk)...
  30. pmc Changes in basic metabolic elements associated with the degeneration and ossification of ligamenta flava
    Zhe Wang
    Institute of Orthopaedics, Xi Jing Hospital, Fourth Military Medical University, Xi an, Shannxi 710032, People s Republic of China
    J Spinal Cord Med 31:279-84. 2008
    To determine the association between levels of basic metabolic elements and degeneration and ossification of the ligamentum flavum (LF).
  31. ncbi Differences in co-variation of inorganic elements in the bulk and surface of human deciduous enamel: an induction analysis study
    T Nilsson
    Department of Pedodontics, Faculty of Odontology, Goteborg University, Sweden
    Connect Tissue Res 38:81-9; discussion 139-45. 1998
    This paper demonstrates a method for determination of co-variation between some inorganic elements in the bulk and surface areas of human tooth enamel...
  32. ncbi Ligand field theory and the origin of life as an emergent feature of the periodic table of elements
    Harold J Morowitz
    Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia, USA
    Biol Bull 219:1-6. 2010
    ..We are now in a position to investigate experimentally the metal-ligand complexes, their catalytic function, and the reaction networks that could have played a role in the development of metabolism and life itself...
  33. ncbi Elements in human placentae in Jamaica
    C Grant
    International Centre for Environmental and Nuclear Sciences, The University of the West Indies, Kingston 7, Jamaica, West Indies
    West Indian Med J 59:479-85. 2010
    ..To investigate the relationships, if any, between elemental content of the placenta with age of mother birthweight and the Apgar scores of a neonate...
  34. ncbi Distributions of arsenic and essential elements in pinna of arsenic hyperaccumulator Pteris vittata L
    Tongbin Chen
    Laboratory of Environmental Remediation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China
    Sci China C Life Sci 48:18-24. 2005
    The distributions of arsenic and 6 essential elements in the pinna of As hyperaccumulator, Pteris vittata L., were studied using synchrotron radiation X-ray fluorescence (SRXRF)...
  35. ncbi Multielement determination and speciation of major-to-trace elements in black tea leaves by ICP-AES and ICP-MS with the aid of size exclusion chromatography
    H Matsuura
    Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Japan
    Anal Sci 17:391-8. 2001
    A multielement determination of major-to-trace elements in black tea leaves and their tea infusions was carried out by ICP-AES (inductively coupled plasma atomic emission spectrometry) and ICP-MS (inductively coupled plasma mass ..
  36. doi Imaging of nutrient elements in the leaves of Elsholtzia splendens by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)
    Bei Wu
    Department of Environmental Engineering, Zhejiang University, Hangzhou 310029, China
    Talanta 78:132-7. 2009
    ..inductively coupled plasma mass spectrometry (LA-ICP-MS) was used for the quantitative imaging of nutrient elements (such as K, Mg, Mn, Cu, P, S and B) in the leaves of Elsholtzia splendens...
  37. ncbi Development of methods for the quantification of essential and toxic elements in human biomonitoring
    Beatrice Bocca
    Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 41:165-70. 2005
    ..The limits were below 0.05 ng ml(-1) for all the elements, except for Al (all matrices), Hg (blood), Pb (blood) and Sn (serum and blood)...
  38. ncbi Age-related changes of element contents in human tendon of the iliopsoas muscle and the relationships among elements
    Motohisa Yamada
    Department of Orthopedic Surgery, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Biol Trace Elem Res 91:57-66. 2003
    ..found that both Mg and P in the tendon of the iliopsoas muscle increased significantly with aging, but the other elements, such as S, Ca, Na, Zn, Fe, and Si, hardly changed with aging...
  39. ncbi Element fluxes through European forest ecosystems and their relationships with stand and site characteristics
    W de Vries
    Alterra, Wageningen University and Research Centre, Droevendaalse steeg 3, P O Box 47, NL 6700 AA Wageningen, The Netherlands
    Environ Pollut 148:501-13. 2007
  40. ncbi Assessment of macro and microelement accumulation capability of two aquatic plants
    Daniela Baldantoni
    Dipartimento di Biologia Vegetale, Universita Degli Studi Di Napoli, Federico II Via Foria, 223 80139 Napoli, Italy
    Environ Pollut 130:149-56. 2004
    ..Phragmites communis, available through the year, showing high capability to accumulate trace metals in the roots, appears a good monitor of lake contamination, better than Najas marina...
  41. ncbi Apportionment of ambient primary and secondary fine particulate matter at the Pittsburgh National Energy Laboratory particulate matter characterization site using positive matrix factorization and a potential source contributions function analysis
    Donald V Martello
    National Energy Technology Laboratory, U S Department of Energy, Pittsburgh, PA, USA
    J Air Waste Manag Assoc 58:357-68. 2008
    ..In contrast, the major local secondary sources are dominated by organic material...
  42. ncbi Bioaccessibility of metals in dust from the indoor environment: application of a physiologically based extraction test
    Andrew Turner
    School of Earth, Ocean and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
    Environ Sci Technol 41:7851-6. 2007
    ..We attribute these observations to precipitation and/or readsorption in the intestine, stabilization by complexation, or anion-like adsorption of negatively charged, polyatomic species, respectively...
  43. ncbi Relationships among element contents in the intimal, middle, and external tunicae of the thoracic aorta
    Y Moriwake
    Laboratory of Cell Biology, Department of Anatomy, Nara Medical University, Kashihara, Japan
    Biol Trace Elem Res 83:121-32. 2001
    To examine an accumulation of elements within the arteries with aging, the authors investigated the element contents in the intimal, middle, and external tunicae of the thoracic aorta...
  44. ncbi Epiphytic lichen growth abnormalities and element concentrations as early indicators of forest decline
    T Otnyukova
    V N Sukachev s Institute for Forest Research, Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036, Russia
    Environ Pollut 146:359-65. 2007
    ..Crown canopy architecture, surface microtopography and the balance between the processes of deposition and the movement and loss of particles play a major role in particle interception and in pollutant delivery to Usnea...
  45. ncbi Urban geochemistry: a multimedia and multielement survey of a small town in northern Europe
    Pasi Peltola
    Department of Geology, Abo Akademi University, FIN 20500 Abo, Finland
    Environ Geochem Health 25:397-419. 2003
    The concentrations and distributions of chemical elements (Ag, Al, As, Au, Ba, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, Hg, K, La, Mg, Mn, Mo, Na, Ni, P, Pb, S, Sb, Sc, Se, Sr, Te, Th, Ti, Tl, U, V, W and Zn) were studied in till, humus and urban ..
  46. ncbi Microchemical element imaging of yeast and human cells using synchrotron X-ray microprobe with Kirkpatrick-Baez optics
    Richard Ortega
    Chimie Nucléaire Analytique et Bioenvironnementale, CNRS Université de Bordeaux 1, BP 120 33175 Gradignan cedex, France
    Anal Chem 76:309-14. 2004
    ..for modern analytical chemistry in order to better understand the biological chemistry of essential and toxic elements. A focusing system based on Kirkpatrick-Baez design optics mounted on a synchrotron radiation scanning X-ray ..
  47. ncbi Current multi-element distribution in forest epigeic moss in the Czech Republic--a survey of the Czech national biomonitoring programme 2000
    J Sucharova
    Silva Tarouca Research Institute for Landscape and Ornamental Gardening, Kvetnove nam 391, Průhonice CZ 252 43, Czech Republic
    Chemosphere 57:1389-98. 2004
    The content of 35 elements was determined in moss samples collected at 250 sites in the Czech Republic (CZ) in 2000...
  48. ncbi Simultaneous analysis of cadmium, lead, mercury, and arsenic content in foodstuffs of animal origin by inductively coupled plasma/mass spectrometry after closed vessel microwave digestion: method validation
    Laurent Noël
    Agence Francaise de Securite Sanitaire des Aliments, Unité Contaminants Inorganiques et Minéraux de l Environnement, Equipe Métaux Lourds et Elements Minéraux 23, avenue du General de Gaulle, F 94706 Maisons Alfort Cedex, France
    J AOAC Int 88:1811-21. 2005
    ..The results indicated that this method could be used in the laboratory for the routine determination of these 4 cumulative toxic metals in foodstuffs with acceptable analytical performance...
  49. ncbi Effect of protein deficiency on macroelement and trace element levels of weanling rats' small intestine and liver tissues
    D Kilicalp
    Department of Physiology, Faculty of Veterinary Medicine, University of Yuzuncu Yil, 65080 Van, Turkey
    Biol Trace Elem Res 107:255-61. 2005
    ..the effect of protein deficiency on the small intestine and liver tissue content of macroelements and trace elements was investigated in weanling rats. Forty-five male weanling Wistar albino rats were divided into three groups...
  50. pmc Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae
    David J Eide
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Genome Biol 6:R77. 2005
    ..coupled plasma-atomic emission spectroscopy (ICP-AES), we assayed 4,385 mutant strains for the accumulation of 13 elements (calcium, cobalt, copper, iron, potassium, magnesium, manganese, nickel, phosphorus, selenium, sodium, sulfur, ..
  51. ncbi Relations between Scots pine needle element concentrations and decreased needle longevity along pollution gradients
    Jukka Lamppu
    Department of Biology, University of Oulu, PO Box 3000, FIN 90014 University of Oulu, Finland
    Environ Pollut 122:119-26. 2003
    ..Decreased Mn accumulation along with needle age was detected near all pollution sources. Leaching of Mn from needles and especially from soil as a cause of decreased needle concentrations is discussed...
  52. ncbi Trace metal characterisation of marine sediment reference materials MESS-3 and PACS-2 in dilute HCl extracts
    Ashley T Townsend
    Central Science Laboratory, University of Tasmania, Private Bag 74, Hobart 7001, Tasmania, Australia
    Mar Pollut Bull 54:236-9. 2007
  53. ncbi Determination of twenty-five elements in lichens by sector field inductively coupled plasma mass spectrometry and microwave-assisted acid digestion
    Anna Pino
    Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Rome, Italy
    Rapid Commun Mass Spectrom 21:1900-6. 2007
    A simple and efficient digestion method for rapid sample preparation and quantification of 25 chemical elements in lichens by sector field inductively coupled plasma mass spectrometry is described...
  54. ncbi Nutritional and toxicological importance of macro, trace, and ultra-trace elements in algae food products
    Christine Dawczynski
    Institute of Nutrition, Friedrich Schiller University, Dornburger Strasse 24, D 07743 Jena, Germany
    J Agric Food Chem 55:10470-5. 2007
    The content of 5 macro elements (Na, K, Ca, Mg, and P), 6 trace elements (Fe, Mn, Zn, Cu, Se, and I), and 4 ultra-trace elements (As, Pb, Cd, and Hg) in 34 edible dried seaweed products of brown algae (Laminaria sp...
  55. ncbi Chemistry of rocks and soils at Meridiani Planum from the Alpha Particle X-ray Spectrometer
    R Rieder
    Max Planck Institut fur Chemie, J J Becher Weg 27, D 55128 Mainz, Germany
    Science 306:1746-9. 2004
    The Alpha Particle X-ray Spectrometer on the Opportunity rover determined major and minor elements of soils and rocks in Meridiani Planum...
  56. ncbi A study of the particulate matter PM10 composition in the atmosphere of Chillán, Chile
    José E Celis
    Facultad de Ingeniería Agrícola, Universidad de Concepcion, Av Vicente Mendez 595, Casilla 537, Chillan, Chile
    Chemosphere 54:541-50. 2004
    ..The PM10 concentrations were higher in the downtown area of the city of Chillán, where also the chemical composition was more variable due to urban traffic and other anthropogenic sources...
  57. ncbi Analysis of aerosol particles and coarse particulate matter concentrations in Chillán, Chile, 2001-2003
    José E Celis
    Department of Animal Science, Faculty of Veterinary Medicine, Universidad de Concepcion, Chillan, Chile
    J Air Waste Manag Assoc 56:152-8. 2006
  58. ncbi Comparison of the moss Pleurozium schreberi with needles and bark of Pinus sylvestris as biomonitors of pollution by industry in Stalowa Wola (southeast Poland)
    A Samecka-Cymerman
    Department of Ecology and Nature Protection, Wroclaw University, 50 328 Wroclaw, Poland
    Ecotoxicol Environ Saf 65:108-17. 2006
    ..schreberi. Bark was a better accumulator of Cd, Cu, and Ni and an inferior accumulator of Mn compared to P. schreberi in the examined area...
  59. ncbi Elemental composition of tropospheric aerosols in Hanoi, Vietnam and Nairobi, Kenya
    Michael Gatari
    Department of Chemistry, Atmospheric Science, Goteborg University, SE 412 96 Goteborg, Sweden
    Sci Total Environ 341:241-9. 2005
    ..Pb and other toxic elements had concentration levels below WHO guideline, however, the two cities are threatened by future high levels of air ..
  60. ncbi Active moss biomonitoring applied to an industrial site in Romania: relative accumulation of 36 elements in moss-bags
    O A Culicov
    Joint Institute for Nuclear Research, Dubna, Russia
    Environ Monit Assess 108:229-40. 2005
    ..The samples were analyzed for 36 elements using instrumental neutron activation analysis (INAA)...
  61. ncbi Advances in integrated and continuous measurements for particle mass and chemical composition
    Judith C Chow
    Division of Atmospheric Sciences, Desert Research Institute, Reno, NV 89512, USA
    J Air Waste Manag Assoc 58:141-63. 2008
    ..Efforts are made to quantify mass by collocating with other particle sizing instruments. Common parameters should be identified and consistent approaches are needed to establish comparability among measurements...
  62. ncbi Elemental content of lichens of the Point Reyes Peninsula, northern California
    James P Bennett
    U S Geological Survey and Institute for Environmental Studies, University of Wisconsin, 445 Henry Mall, Madison, WI 53706, USA
    Sci Total Environ 343:199-206. 2005
    ..Although gaseous pollutants are not a problem, fine particulates containing carbon and other elements are measurable at the park...
  63. ncbi Investigation of elemental content distribution in femoral head slice with osteoporosis by SRXRF microprobe
    Yuanxun Zhang
    Shanghai Institute of Applied Physics, The Chinese Academy of Sciences, Shanghai 201800, China
    Biol Trace Elem Res 103:177-85. 2005
    ..Combined with the correlation among P, K, Zn, Sr, and Ca, the route of loss of minerals and the physiological functions of some metal elements in bone are also discussed.
  64. ncbi Rare and scattered elements in soil invertebrates
    K B Gongal'skii
    Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninskii pr 33, Moscow, 117071 Russia
    Dokl Biol Sci 389:134-7. 2003
  65. ncbi Contribution of endotoxin in macrophage cytokine response to ambient particles in vitro
    Song Lih Huang
    Institute of Environmental Health Sciences, National Yang Ming University, Taipei, Taiwan
    J Toxicol Environ Health A 65:1261-72. 2002
    ..Results suggest that endotoxin and other components may be important factors for TNF-alpha production by macrophages in vitro...
  66. ncbi Temporal changes in the elemental composition of Rhizopogon rhizomorphs during colonization of patches with fresh organic matter or acid-washed sand
    Håkan Wallander
    Department of Microbial Ecology, University of Lund, Ecology Building, SE 223 62 Lund, Sweden
    Mycologia 97:295-303. 2005
    ..mass per unit area was analyzed with scanning transmission ion microscopy (STIM), and the elemental content of elements heavier than Mg were analyzed with particle induced X-ray emission (PIXE)...
  67. ncbi [The possibilities of element status evaluation in determination of antiviral therapy resistance in patients with chronic hepatitis C]
    I G Bakulin
    Voen Med Zh 327:46-8. 2006
  68. ncbi Effect of organic substrates on available elemental contents in nutrient solution
    Yansong Ao
    School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China
    Bioresour Technol 99:5006-10. 2008
    ..Thus, a mathematical model was proposed for adjusting the composition of supplied nutrient solution to match plant requirements in the organic soilless culture system...
  69. ncbi Origin assignment of unidentified corpses by use of stable isotope ratios of light (bio-) and heavy (geo-) elements--a case report
    Elisabeth Rauch
    Institute of Forensic Medicine, Ludwig Maximilians University Munich, Frauenlobstr 7a, 80337 Munich, Germany
    Forensic Sci Int 168:215-8. 2007
    ..The combined analysis of stable isotope ratios of light (H, C, N) and heavy elements (Pb, Sr) on the man's body tissues supported to assign him to Romania...
  70. doi Use of pulp mill inorganic wastes as alternative liming materials
    F Cabral
    UIQA, Instituto Superior de Agronomia, TU Lisbon, Tapada da Ajuda, 1349 017 Lisboa, Portugal
    Bioresour Technol 99:8294-8. 2008
    ..Finally, metals do not seem to be a limiting factor for the application to land of these by-products...
  71. ncbi Effects of sewage sludge amendment on the properties of two Brazilian oxisols and their humic acids
    E I Bertoncini
    APTA Pólo Regional Centro Sul, PO 28, 13400 970 Piracicaba, SP, Brazil
    Bioresour Technol 99:4972-9. 2008
    ..In particular, N-containing groups and aliphatic structures of SS-HA-like sample appears to be partially incorporated in the amended soil HAs, and these effects were more evident in the HAs from the sandy oxisol...
  72. ncbi The impact of pumped water from a de-watered Magnesian limestone quarry on an adjacent wetland: Thrislington, County Durham, UK
    W M Mayes
    Institute for Research on Environment and Sustainability, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Environ Pollut 138:443-54. 2005
    ..This encompassed high pH (up to 12.8), sediment-rich effluent creating a nutrient-poor substrate with poor moisture retention in the quarry wetland, and large fluctuations in water levels...
  73. doi Content, distribution and fate of 33 elements in sediments of rivers receiving wastewater in Hanoi, Vietnam
    Helle Marcussen
    Department of Natural Sciences, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark
    Environ Pollut 155:41-51. 2008
    ..The aim of this study was to assess the content, distribution and fate of 33 elements in the sediment and pore water of the main wastewater receiving rivers...
  74. ncbi Geochemistry of extremely alkaline (pH>12) ground water in slag-fill aquifers
    George S Roadcap
    Illinois State Water Survey, Champaign 61820, USA
    Ground Water 43:806-16. 2005
    ..Air sparging appears to be an effective remediation strategy for reducing the toxicity of discharging alkaline water...
  75. ncbi Assessment of sampling and chemical analysis of source-separated organic household waste
    Jes la Cour Jansen
    Water and Environmental Engineering, Lund University, P O Box 118, SE 221 00 Lund, Sweden
    Waste Manag 24:541-9. 2004
  76. ncbi Element concentrations of dry-grind corn-processing streams
    Ronald L Belyea
    Animal Science, University of Missouri, Columbia, MO 65211, USA
    Appl Biochem Biotechnol 134:113-28. 2006
    ..Two issues relate to elements in DDGS: high concentrations and excessive variation...
  77. ncbi The influence of living habits and family relationships on element concentrations in human hair
    K Chojnacka
    Institute of Inorganic Technology and Mineral Fertilizers, Wrocław University of Technology, ul Smoluchowskiego 25, 50 372 Wrocław, Poland
    Sci Total Environ 366:612-20. 2006
    The paper discusses the content of elements in hair of subjects studied over several years. The study was performed on 5 subjects (N=28) that lived together or were family related...
  78. ncbi Levels of inorganic constituents in raw nuts and seeds on the Swedish market
    I Rodushkin
    Division of Applied Geology, Lulea University of Technology, S 971 87 Lulea, Sweden
    Sci Total Environ 392:290-304. 2008
    The levels of approximately 70 elements were determined in different culinary nuts (hazelnuts, walnuts, almonds, bitter almonds, pecans, cashews, Brazil nuts, pistachios, pine nuts, peanuts and coconuts) and seeds (pumpkin and sunflower) ..
  79. ncbi Geochemical background--concept and reality
    Clemens Reimann
    Geological Survey of Norway, N 7491 Trondheim, Norway
    Sci Total Environ 350:12-27. 2005
    ..Although global averages are of general use, no specific global background levels of elements, for example in soils, can be defined, at best regional or local operational estimates can be made, though with ..
  80. ncbi Characterization of particulate matter for three sites in Kuwait
    Kathleen Ward Brown
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Air Waste Manag Assoc 58:994-1003. 2008
    ..5), as well as fine particle nitrate, sulfate, elemental carbon (EC), organic carbon (OC), and elements measured at the three sites...
  81. ncbi Temporal trends of total and potentially available element concentrations in sewage biosolids: a comparison of biosolid surveys conducted 18 years apart
    I W Oliver
    Department of Soil and Water, Adelaide University Waite Campus, PMB 1 Glen Osmond, South Australia 5064, Australia
    Sci Total Environ 337:139-45. 2005
    ..Therefore, total concentrations of elements in biosolids and the fraction potentially available to organisms must be known in order to accurately gauge the ..
  82. ncbi Effects of Schistosoma mansoni infection on inorganic elements in the snail Biomphalaria glabrata
    J H L Ong
    Department of Chemistry, Lafayette College, Easton, PA 18042, USA
    J Helminthol 78:343-6. 2004
    ..Cohort snails that were left uninfected were analysed at the same time as the infected snails. Sixteen elements (aluminum, boron, barium, calcium, cadmium, copper, iron, potassium, magnesium, manganese, sodium, nickel, lead, ..
  83. ncbi Element-selective detection in liquid and gas chromatography by diode laser absorption spectrometry
    Alexander Zybin
    ISAS Institute for Analytical Sciences, Bunsen Kirchhoff Strasse 11, 44139 Dortmund, Germany
    J Chromatogr A 1050:35-44. 2004
    ..The analytical utility of the technique is demonstrated by speciation examples of HPLC and GC employing analytical flames and plasmas to atomize...
  84. ncbi Toothbrushing causes elemental release from dental casting alloys over extended intervals
    John C Wataha
    Department of Oral Rehabilitation, School of Dentistry, Medical College of Georgia, Augusta, Ga 30912 1260, USA
    J Biomed Mater Res B Appl Biomater 65:180-5. 2003
    The release of elements from dental alloys has been linked to alloy biocompatibility. Much of the research measuring elemental release has been done in vitro under passive conditions...
  85. ncbi Recent trends in CE of inorganic ions: from individual to multiple elemental species analysis
    Andrei R Timerbaev
    Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Moscow, Russia
    Electrophoresis 28:3420-35. 2007
  86. ncbi Role of endoplasmic reticulum-derived vesicles in the formation of Golgi elements in sec23 and sec18 Saccharomyces Cerevisiae mutants
    M N Morin Ganet
    , CEA Saclay, France
    Anat Rec 251:256-64. 1998
    ..37 degrees C) temperature, the secretory pathway is blocked between endoplasmic reticulum (ER) and Golgi elements. When examined with an electron microscope, sec23 displays an excess of ER membranes, whereas sec18 accumulates ..
  87. ncbi [Comparative study on eight trace elements in twelve flower medicines]
    Ying Feng Niu
    Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xi ning 810008, China
    Guang Pu Xue Yu Guang Pu Fen Xi 29:1997-2000. 2009
    Eight trace elements such as Ca, Cu, Fe, Mn, Zn, K, Mg and Na in twelve kinds of flower medicines were determined by flame-atomic absorption spectrometry with air-acetylene flame. The flower medicines include Pueraria lobata Ohwi...
  88. ncbi Trace elements and the European skeleton through 5000 years
    C Smrcka
    Center for Patients with Locomotor Defects, Prague
    Acta Univ Carol Med (Praha) 41:59-68. 2000
    ..C-400 A.D.), the Middle Ages and from contemporary cadavers. We found the following distribution of elements in the longitudional axis of long bones (the femurs and the tibias)...
  89. ncbi [Determination of the contents of trace elements in chinese herbal medicines for treating respiratory system diseases]
    Li qin Han
    Department of Chemistry, Jilin Medical College, Jilin 132013, China
    Guang Pu Xue Yu Guang Pu Fen Xi 28:453-5. 2008
    There is an intimate connection between trace elements and body healthiness, trace elements and organism depend on each other, and each trace element exists with certain proportion, which preserve physio-function...
  90. doi Serum trace elements in tube-fed neurological dysphagia patients correlate with nutritional indices but do not correlate with trace element intakes: case of patients receiving enough trace elements intake
    Hitoshi Obara
    Department of Nutrition Management, National Hospital Organization Kamaishi National Hospital, Sadanaicho 4 7 4, Kamaishi, Iwate 026 0053, Japan
    Clin Nutr 27:587-93. 2008
    ..Since trace elements in serum bind to serum protein, serum trace elements concentration is influenced by serum protein concentration...
  91. ncbi Iodine status and the effect of soil erosion on trace elements in Nanka and Oba towns of Anambra State, Nigeria
    Ifeyinwa C Olife
    Department of Applied Biochemistry, Nnamdi Azikiwe University, Awka
    Ann Chim 97:895-903. 2007
    Iodine Deficiency Disorders (IDD) is common in all populations. Iodine and other trace elements naturally occur in the soil but erosion leaches off these elements from the soil...
  92. ncbi X-ray microanalysis of biological specimens by high voltage electron microscopy
    Tetsuji Nagata
    Department of Anatomy and Cell Biology, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    Prog Histochem Cytochem 39:185-319. 2004
    ..Among the physical methods, two methods qualifying and quantifying the elements in the structural components are very often employed...
  93. doi Implications of metal accumulation mechanisms to phytoremediation
    Abdul R Memon
    TUBITAK, Marmara Research Center, Institute for Genetic Engineering and Biotechnology, P O Box 21, 41470, Gebze, Kocaeli, Turkey
    Environ Sci Pollut Res Int 16:162-75. 2009
    Trace elements (heavy metals and metalloids) are important environmental pollutants, and many of them are toxic even at very low concentrations...
  94. ncbi Distribution of trace elements in tissues of two shrimp species from the Persian Gulf and roles of metallothionein in their redistribution
    N Pourang
    Department of Environment and Sustainable Agriculture, Ministry of Jahad e Agriculture, 7th Floor Tehran, Iran
    Environ Int 31:325-41. 2005
    This study investigates the distribution of three trace elements (Cd, Cu and Zn) in tissues (exoskeleton, abdominal muscle and hepatopancreas) of two shrimp species (Penaeus merguiensis and Penaeus semisulcatus)...
  95. ncbi Promoter elements and transcription factors involved in differentiation-dependent human chorionic gonadotrophin-alpha messenger ribonucleic acid expression of term villous trophoblasts
    M Knöfler
    Department of Obstetrics and Gynecology, University of Vienna, Austria
    Endocrinology 141:3737-48. 2000
    ..Site-directed mutations in each of the five DNA-elements of the composite enhancer were performed to investigate the contribution of the individual regulatory sequences ..
  96. ncbi Interferon-gamma regulation of the human mimecan promoter
    Elena S Tasheva
    Division of Biology, Kansas State University, Manhattan 66506 4901, USA
    Mol Vis 9:277-87. 2003
    The human mimecan/osteoglycin promoter contains multiple interferon-stimulated response elements (ISRE) and interferon-gamma-activation sites (GAS). ISRE and GAS motifs are present in a variety of interferon (IFN)-inducible genes...
  97. ncbi Isolation of SDS-stable complexes of the intermediate filament protein vimentin with repetitive, mobile, nuclear matrix attachment region, and mitochondrial DNA sequence elements from cultured mouse and human fibroblasts
    G V Tolstonog
    Max Planck Institut für Zellbiologie, Ladenburg Heidelberg, Germany
    DNA Cell Biol 20:531-54. 2001
    ..with anti-vimentin antibody, contained substantial quantities, not only of repetitive and mobile sequence elements such as centromeric satellite DNA, telomere DNA, microsatellites and minisatellites, long and short interspersed ..
  98. ncbi Contrast-to-noise ratios of different elements in digital mammography: evaluation of their potential as new contrast agents
    Felix Diekmann
    Department of Radiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Invest Radiol 42:319-25. 2007
    To determine the contrast-to-noise ratios (CNRs) of different elements at different energies using various anode/filter combinations currently employed in digital mammography...
  99. ncbi Monitoring of copper, arsenic and antimony levels in agricultural soils impacted and non-impacted by mining activities, from three regions in Chile
    Ida De Gregori
    Laboratorio de Química Analítica y Ambiental, Instituto de Quimica, Universidad Catolica de Valparaiso, Avenida Brasil 2950, Valparaiso, Chile
    J Environ Monit 5:287-95. 2003
    This paper reports a comparative study of the concentration of three important environmental elements that are often found together in mineral deposits and then associated with mining activities; copper, arsenic and antimony...
  100. ncbi In vitro activity of cefadroxil, cephalexin, cefatrizine and cefpirome in presence of essential and trace elements
    Najma Sultana
    Department of Pharmaceutical Chemistry, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 20:305-10. 2007
    Evidences supporting the introduction of metallic elements in several biological processes are rapidly accumulating. Likewise, many drugs possess modified toxicological and pharmacological properties when in the form of metal complexes...
  101. pmc Identification and characterization of Tc1/mariner-like DNA transposons in genomes of the pathogenic fungi of the Paracoccidioides species complex
    Marjorie M Marini
    Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, MG, Brazil
    BMC Genomics 11:130. 2010
    ..In this study the identification and characterization of class II transposable elements in the genomes of these fungi was carried out.

Research Grants73

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. High Throughput Genotyping and DNA Sequencing for Studying the Genetic Contributi
    Sonia Dua; Fiscal Year: 2013
    ..The contractor will deposit any data produced deemed to be covered by a data sharing policy. There are many elements to such datasets...
  3. Regulation of HSV-1 Gene Expression and Replication by Nuclear Hormone Receptors
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2013
    ..In searching for hormone responsive elements in HSV-1 genome, we identified thyroid hormone receptor responsive elements (TREs) in the regulatory regions of ..
  4. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..Cytoskeletal elements, including actin-based corrals and cortical cytoskeleton networks, restrict receptor mobility and may also serve ..
    Carole R Mendelson; Fiscal Year: 2013
    ..1) and nuclear factor (B (NF-(B), upstream stimulatory factors (USFs) 1 and 2, and Sp1 to critical response elements upstream of the SP-A gene...
  6. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..By testing different conditions we will support or refute elements of our hypothesis. 1...
  7. Regulation of ER stress-induced cell death
    Randal J Kaufman; Fiscal Year: 2013
    ..In addition, our preliminary unpublished findings show that CHOP does not significantly bind promoter elements of genes that encode apoptotic functions, but rather binds to promoters of genes that encode functions in protein ..
  8. Cellular &Inflammatory Pathways in Ashtma &Allergic Diseases: From IgE to Cells
    LAWRENCE BARRY SCHWARTZ; Fiscal Year: 2012
    ..As described above, these cellular and molecular elements all likely contribute to various aspects of the pathogenesis of allergic asthma and other allergic diseases...
  9. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..of the LO promoter activation regulated by metal and redox-sensitive transcription factors and their cognate cis-elements, and determining LO promoter methylation to provide evidence for Cd epigenetic damage to LO DNA;3) to identify ..
  10. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ..in trans with the liganded vitamin D receptor (VDR) and estrogen receptor 1 (ER1) for their cognate response elements, identifying them as nucleic acid binding proteins in the heterogeneous nuclear ribonucleoprotein C (hnRNPC) ..
    Pi Wan Cheng; Fiscal Year: 2010
    ..2. Characterize C2GnT-M gene regulation by mapping cis-regulatory elements and identifying the cognate transcription factors under basal conditions...
  12. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..of smooth muscle cell PI3-kinase/Akt survival pathway, mitochondrial respiration and Ca++ uptake by neural redox elements in bladder ischemia...
  13. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    ..The key elements of this plan are structured training in the pathophysiology of acute oxidant injury, mitochondrial dysfunction, ..
  14. Role and Regulation of INrf2
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..The studies may also provide the basis for further analysis of identified targets (cis- and trans-elements) that could ultimately allow us to increase the chemoprotective capacity of cells.
    Lisa M Salati; Fiscal Year: 2012
    ..These regions contain juxtaposed splicing silencing and enhancing elements. The binding of splicing inhibitory proteins to the silencer exclude the binding of splicing activators proteins ..
  16. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..Key elements of my career goal are 1) to develop human models of cardiac arrhythmia to examine how cardiac arrhythmia occurs ..
  17. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..Key elements of my career goal are 1) to develop human models of cardiac arrhythmia to examine how cardiac arrhythmia occurs ..
  18. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..RFP topic stating their objective and mission that "human health and human disease result from three interactive elements: environmental exposure, genetic susceptibility, and age...
  19. Human neutrophils, phospholipase A2 and S.aureus: microbial targets and responses
    William M Nauseef; Fiscal Year: 2013
    ..Understanding the mechanisms by which innate immune elements, including PMN and GpIIA-PLA2, mediate successful killing and degradation of SA will provide fundamental insights ..
  20. Expression of sFlt1 and its function in the glomerular endothelium
    Christie P Thomas; Fiscal Year: 2013
    ..We also hypothesize that cis-elements within FLT1 locus regulates the abundance of Flt1 and sFlt1 transcripts...
  21. Epigenomic Events in Development of the Locus Coeruleus Noradrenergic Neurons
    Jan Krzysztof Blusztajn; Fiscal Year: 2012
    ..using transgenic mice that express enhanced green fluorescent protein (EGFP) under the control of the regulatory elements of genes expressed exclusively in these populations...
  22. Chemical modulators of Tet-family proteins
    Anjana Rao; Fiscal Year: 2010
    ..5-methylcytosine (5mC) is found at high levels at repetitive elements, telomeres and the inactive X-chromosome in females, and its presence correlates with diminished gene expression...
  23. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..Furthermore, it remains unknown how the SynCAMs, and CAMs in general, bring about the recruitment of synaptic elements to new adhesive contacts...
  24. Autoimmunity Center of Excellence (ACE) at Stanford
    ..arthritis (SJIA)] that afflict adults and children, as well as organ systems including joints, skin, blood elements, and blood vessels, and will both test efficacy of therapy and develop tests to characterize the mechanisms of ..
  25. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..Of interest are responses involving activation of the c-Ha-ras gene and long interspersed nuclear elements (LINE 1 or L1) in human and murine vSMCs...
    RAMON E PARSONS; Fiscal Year: 2012
    ..In aim 3, we will investigate how PTEN regulates FOXO transcription factors to activate a target gene. DNA elements will be identified on the promoter that coordinate gene activation...
  27. Prevention of age-associated musculoskeletal loss by n-3 fatty acids
    Md Mizanur Rahman; Fiscal Year: 2013
    ..The key elements of my research career development plan are: (1) gain education/training on new technologies/advanced basic and ..
  28. Preclinical drug trial in mouse models of inflammation
    Kanneboyina Nagaraju; Fiscal Year: 2011
    ..side effects (metabolic and hormonal) are thought to be predominantly mediated by transactivation via GC response elements in the nucleus...
  29. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2013
    ..However, the most common targets for A I editing are non-coding RNAs that contain inverted repeats of repetitive elements such as Alu and LINE located within introns and 3'UTRs...
  30. Molecular Biology of Human Erythrocyte Alpha Spectrin
    Patrick G Gallagher; Fiscal Year: 2013
    ..Previously known and newly identified cis-regulatory elements in the ?- spectrin gene will be interrogated and characterized in functional studies of gene regulation...
  31. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring
    Santhisagar Vaddiraju; Fiscal Year: 2010
    ..Objective/Hypothesis: By outfitting our implantable glucose sensing platform with two additional sensing elements capable of independently assessing oxygen and various interfering agent levels, the accuracy and reliability of ..
  32. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
    ..ectopic expression of procolipase and PLRP2 in response to metabolic stimuli and 3) to identify the cis-acting elements that regulate the ectopic expression of procolipase using HepG2 cells...
  33. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    ..This was a breakthrough discovery for our laboratory, as no putative Rhox5-response elements had ever discovered...
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2013
    ..CLDs are important homeostatic elements in cellular and tissue lipid metabolism and may serve to limit the availability of potentially toxic free fatty ..
  35. Genetic &Functional Analyses of Hypertension Susceptibility Genes
    YEN PEI CHRISTY CHANG; Fiscal Year: 2013
    ..expertise in transcriptional regulation and bioinformatics to mine the ever-expanding annotation of regulatory elements in the human genome...
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..IRP2 is a RNA-binding protein that binds to iron-responsive elements (IREs) located in mRNAs of proteins involved in iron uptake, sequestration and export...
  37. Roles of RNA Polymerases IV and V in siRNA-mediated gene silencing
    CRAIG STUART PIKAARD; Fiscal Year: 2013
    ..These novel RNA polymerases play non- redundant roles in RNA-directed DNA methylation, silencing of transposable elements, large-scale heterochromatin organization, long-distance spreading of silencing signals, and proper temporal and ..
  38. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    ..erectile support system, able to be used throughout intercourse and designed, using scaled-down elements of the sphygmomanometer, to gently and non-ischemically compress ambient fluids permitting the then flaccid or ..
  39. Development and Validation of an Instrument to Assess Cognitive Function Regulati
    Xi Chen; Fiscal Year: 2013
    ..A prototype instrument has also been developed and is now ready for further testing. All of these elements have prepared Dr. Chen to become an independent investigator in geriatric dental research...
    ANN NARDULLI; Fiscal Year: 2013
    ..are initiated by binding to the estrogen receptor (ER) and inducing the receptor to bind to estrogen response elements (EREs) residing in target genes...
  41. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..Because PPAR3 and PPAR1 share the same peroxisome response elements and can be transactivated by the same ligands, we hypothesize therefore, that PPAR3 will play a defined role in ..
    John R Grider; Fiscal Year: 2013
    ..between luminal stimulants, paracrine agents released from mucosal enteroendocrine cells, and the neural elements which make up the sensory (afferent), interneuronal, and motor circuits of the reflex...
  43. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ..Three specific aims will guide the work. Aim 1 is to dissect the proximal elements of this signal transduction pathway as a means of defining the early targets of H2O2, focusing on the H2O2-..
  44. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
    ..recurring patterns, especially groupings of transcription factor-binding motifs, within NF-E2-occupied cis-elements in MK-expressed genes...
  45. Neuropeptide modulation of biogenic amine function and aggression in a crustacean
    Maria A Sosa; Fiscal Year: 2013
    ..behavior in crustaceans, including the prawn, but the evidence suggests that they are not the sole determinant elements. Aggression and fighting behavior can vary depending on circumstances such as availability of food, shelter and ..
    Quentin J Baca; Fiscal Year: 2010
    ..He will experimentally examine associations of the CD45 receptor with other cytoskeletal elements such as actin and microtubules to test their role in regulation of receptor mobility...
    Juanita L Merchant; Fiscal Year: 2013
    ..g., butyrate or trichostatin A (TSA). Butyrate induces ZBP-89 expression and binding to GC-rich DNA elements in several promoters including the cyclin-dependent kinase inhibitor (CDKI) p21...
  48. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..A 7 survey conducted in 2011-2012 revealed over 50 contamination events nationwide attributed to 8 trace elements and heavy metals such as copper, sulfur, lead, arsenic, zinc, selenium and 9 phosphorus...
    Peter B Dervan; Fiscal Year: 2013
    ..the inflammatory response through a variety of mechanisms, including DNA binding of glucocorticoid response elements (GREs)...
  50. OmpR and SsrB Regulation of Salmonella Virulence
    Linda J Kenney; Fiscal Year: 2013
    ..In this proposal, critical cis and trans regulatory elements for ssrA/ssrB expression under a variety of environmental conditions will be identified...
    Sanjay Awasthi; Fiscal Year: 2011
    ..These proteins are key elements of cell membrane plasticity, actin-cytoskeletal regulation and cell migration (cancer cell invasion and ..
  52. Regulation of insulator function and globin gene expression by USF and associated
    Suming Huang; Fiscal Year: 2013
    ..Erythroid-specific expression of the globin genes requires cis-regulatory DNA elements located in gene proximal or distal regions...
  53. Biofilm Infections in Postsurgical, Trauma, and Critically Ill Patients
    Carol L Wells; Fiscal Year: 2013
    ..The force behind this proposal is our recent discovery of unusual (heretofore unrecognized), large cellular elements that appear early in biofilm formation (within 15 min) and are likely of critical importance...
    Michael J Smerdon; Fiscal Year: 2013
    ..NCPs and rotationally aligned on the histone surface by bracketing the GRE sequence with NCP positioning elements. Dynamic FRET will be used to monitor the rates of trapping of unwrapped NCPs by DNA repair proteins at site-..
  55. Comparative Effectiveness Research in Pediatric Rheumatic Diseases: Leveraging CA
    CAROL A contact WALLACE; Fiscal Year: 2010
    ..This will be an ongoing resource for comparative effectiveness studies. Data elements will inform the following domains and will allow varying levels of data collection (demographics, core disease ..
  56. New Molecular and Cellular Mechanisms of Glaucoma
    Andrei Surguchov; Fiscal Year: 2013
    ..Post-transcriptional mechanisms including modulation of its translation/or mRNA stability by 3'-UTR elements. Defects in the regulation of MMP-9 lead to a misbalance of its expression, defects in the remodeling of the ECM ..
  57. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    ..ganglion cells by using promoter-reporter and electrophoretic mobility shift assays to identify cis-acting elements and trans-acting factors contributing to constitutive and inducible ETBB expression in the RGC-5 cell line...
  58. The Role of Circadian Periodicity in Human Cardiovascular Disease and Diabetes
    John P Forman; Fiscal Year: 2013
    ..Finally, the relation between elements of the circadian system (i.e...
  59. Genomic Enhancers at 8q24 and Prostate Cancer
    Gerhard A Coetzee; Fiscal Year: 2013
    ..in vivo enhancer activities will be investigated in mice carrying reporter genes controlled by candidate enhancer elements (subaim 1.2)...
  60. Beta-cell Compensation in Partial Pancreatectomy Mice
    JOHN L LEAHY; Fiscal Year: 2013
    ..We will test these hypotheses in mice with genetically altered expression of key elements in the proposed signaling pathways - pancreas specific PPAR? knockout, whole animal heterozygous FoxO1, and ..
    Dennis G Drescher; Fiscal Year: 2013
    ..deficits such as deafness, tinnitus, and dizziness is completely dependent upon our knowledge of basic elements of hair-cell receptoneural transmission, as modulated by efferent neurotransmission...
  62. Regulation of EBV Latency by EBNA1
    Paul M Lieberman; Fiscal Year: 2013
    ..and human papillomavirus (HPV) E2 family members, as well as by cellular factors that protect fragile genetic elements, including telomeres and other repetitive DNA...
  63. Apoptosis and Trophoblast Fusion
    NEAL STEWART ROTE; Fiscal Year: 2010
    ..expression and insertion of fusion proteins into the plasma membrane, and rearrangement of actin cytoskeletal elements. Our preliminary data suggest that several apoptosis-related proteins, particularly caspases 3, 8, and 14, may be ..
  64. Evaluation of RNA transport elements in HIV-1 vectors
    SRINIVAS KUMAR; Fiscal Year: 2007
    DESCRIPTION (provided by applicant): Post-transcriptional regulatory elements (PTREs) effect various aspects of RNA function: transport of RNAs from the nucleus to the cytoplasm, localization of the RNA in specific cellular compartments, ..
  65. A Developmental Craniofacial Atlas for the Zebrafish
    Charles B Kimmel; Fiscal Year: 2010
    ..It will continue with selected stages through the 3-week-old juvenile stage when nearly all of the elements of the skull are present, and shaped approximately as in the adult, but of miniature size...
    Elizabeth Eklund; Fiscal Year: 2000
    ..These linking events are at present poorly characterized. Three unique enhancer elements in the gp91phox promoter addictively increase IFN-g expression...
    CAROLE MENDELSON; Fiscal Year: 2007
    ..is critically dependent upon cooperative interactions of at[unreadable] least four identified DNA response elements which lie within 400 bp[unreadable] upstream of the SP-A transcription initiation site...
  68. New Optics for Trace Level Detection of Toxins in Environmental and Biological Sa
    ZEWU CHEN; Fiscal Year: 2010
    ..fluorescence (XRF) is a convenient, nondestructive, rapid technique that is effective at identifying specific elements in a wide variety of matrices. There are ten elements regulated for their toxic effects world- wide...
    Joseph Glorioso; Fiscal Year: 2000
    ..ii) To characterize cis-acting elements associated with the ICPO promoter during latency or reactivation...
    DAVID SHAFRITZ; Fiscal Year: 1991
    ..Our basic premise is that HBV genetic elements and/or specific viral gene products (regulatory or structural) by virtue of their direct function or a separate ..
  71. Cis-acting RNA elements in hepatitis C virus replication
    Guangxiang Luo; Fiscal Year: 2007
    ..overall goal of this research proposal is to determine the sequence and structural requirements of cis-acting RNA elements in the 5' and 3' UTRs in viral RNA replication...
    JOSEPH GLAWSON; Fiscal Year: 1990
    A major topic in caries research is the influence of the uptake and distribution of fluoride and other elements in making teeth more caries resistant...
  73. Studies of Collagen Gene Regulation in Two Murine Models
    Stephen Clark; Fiscal Year: 2005
    ..Specific aim 1 focuses on identifying cis-acting elements in the type I collagen gene required for the increased production of Collal mRNA in mutant dermal fibroblasts...