Summary: A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling.

Top Publications

  1. ncbi ATR regulates fragile site stability
    Anne M Casper
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 111:779-89. 2002
  2. pmc Caffeine as a potential quorum sensing inhibitor
    Siti Nur Maisarah Norizan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:5117-29. 2013
  3. ncbi Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis
    M Doherty
    Division of Sport and Exercise Science, University of Luton, Luton, Beds LU1 3JU, UK
    Scand J Med Sci Sports 15:69-78. 2005
  4. pmc Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition
    Shinji Saiki
    Department of Neurology, Juntendo University School of Medicine Bunkyo, Tokyo, Japan
    Autophagy 7:176-87. 2011
  5. ncbi Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land
    Harris R Lieberman
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Psychopharmacology (Berl) 164:250-61. 2002
  6. ncbi The effect of caffeine ingestion on 8 km run performance in a field setting
    C A Bridge
    Sport and Exercise Research Group, Edge Hill College, Ormskirk, UK
    J Sports Sci 24:433-9. 2006
  7. ncbi Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Nat Neurosci 8:858-9. 2005
  8. doi Green tea catechins, caffeine and body-weight regulation
    M S Westerterp-Plantenga
    Department of Human Biology, NUTRIM, Faculty of Health, Medicine, and Life Sciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Physiol Behav 100:42-6. 2010
  9. ncbi Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p
    Aaron Reinke
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 281:31616-26. 2006
  10. doi Caffeine effects on short-term performance during prolonged exercise in the heat
    Juan Del Coso
    Universidad de Castilla La Mancha, Toledo, Spain
    Med Sci Sports Exerc 40:744-51. 2008

Detail Information

Publications457 found, 100 shown here

  1. ncbi ATR regulates fragile site stability
    Anne M Casper
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 111:779-89. 2002
    ..These findings have important implications for understanding both the mechanism of fragile site instability and the consequences of stalled replication in mammalian cells...
  2. pmc Caffeine as a potential quorum sensing inhibitor
    Siti Nur Maisarah Norizan
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 13:5117-29. 2013
    ..In this work, we have tested caffeine as quorum sensing inhibitor by using Chromobacterium violaceum CV026 as a biosensor...
  3. ncbi Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis
    M Doherty
    Division of Sport and Exercise Science, University of Luton, Luton, Beds LU1 3JU, UK
    Scand J Med Sci Sports 15:69-78. 2005
    The purpose of this study was to use the meta-analytic approach to examine the effects of caffeine ingestion on ratings of perceived exertion (RPE). Twenty-one studies with 109 effect sizes (ESs) met the inclusion criteria...
  4. pmc Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition
    Shinji Saiki
    Department of Neurology, Juntendo University School of Medicine Bunkyo, Tokyo, Japan
    Autophagy 7:176-87. 2011
    b>Caffeine is one of the most frequently ingested neuroactive compounds. All known mechanisms of apoptosis induced by caffeine act through cell cycle modulation or p53 induction...
  5. ncbi Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land
    Harris R Lieberman
    Military Nutrition Division, U S Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
    Psychopharmacology (Berl) 164:250-61. 2002
    ..When humans are acutely exposed to multiple stressors, cognitive performance is substantially degraded. Few practical strategies are available to sustain performance under such conditions...
  6. ncbi The effect of caffeine ingestion on 8 km run performance in a field setting
    C A Bridge
    Sport and Exercise Research Group, Edge Hill College, Ormskirk, UK
    J Sports Sci 24:433-9. 2006
    The aim of this study was to assess the effect of caffeine ingestion on 8 km run performance using an ecologically valid test protocol. A randomized double-blind crossover study was conducted involving eight male distance runners...
  7. ncbi Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine
    Zhi Li Huang
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    Nat Neurosci 8:858-9. 2005
    b>Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear...
  8. doi Green tea catechins, caffeine and body-weight regulation
    M S Westerterp-Plantenga
    Department of Human Biology, NUTRIM, Faculty of Health, Medicine, and Life Sciences, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Physiol Behav 100:42-6. 2010
    ..Tools for obesity management including caffeine, and green tea have been proposed as strategies for weight loss and weight maintenance...
  9. ncbi Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p
    Aaron Reinke
    Section of Molecular and Cellular Biology, College of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 281:31616-26. 2006
    ..Here we show that caffeine acts as a distinct and novel small molecule inhibitor of TORC1: (i) deleting components specific to TORC1 but not ..
  10. doi Caffeine effects on short-term performance during prolonged exercise in the heat
    Juan Del Coso
    Universidad de Castilla La Mancha, Toledo, Spain
    Med Sci Sports Exerc 40:744-51. 2008
    To determine the effect of water, carbohydrate, and caffeine ingestion on fatigue during prolonged exercise in the heat.
  11. ncbi Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans
    A G Dulloo
    Department of Physiology, Faculty of Medicine, University of Geneva
    Am J Clin Nutr 70:1040-5. 1999
    ..Current interest in the role of functional foods in weight control has focused on plant ingredients capable of interfering with the sympathoadrenal system...
  12. ncbi A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, caffeine and phenobarbital
    Lee Willoughby
    Centre for Environmental Stress and Adaptation Research CESAR, Department of Genetics, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia
    Insect Biochem Mol Biol 36:934-42. 2006
    ..These results are in contrast to induction responses we observed for the natural plant compound caffeine and the barbituate drug phenobarbital, both of which highly induced a number of P450 and GST genes under the same ..
  13. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
    We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States...
  14. ncbi Coffee, caffeine and blood pressure: a critical review
    M L Nurminen
    Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, Finland
    Eur J Clin Nutr 53:831-9. 1999
    We review the published data relating to intake of coffee and caffeine on blood pressure in man. We also refer to studies on the possible mechanisms of actions of these effects of caffeine.
  15. doi Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis
    Jeffrey W Molloy
    Divison of Gastroenterology and Hepatology, Wilford Hall Medical Center, Lackland Air Force Base, TX, USA
    Hepatology 55:429-36. 2012
    Coffee caffeine consumption (CC) is associated with reduced hepatic fibrosis in patients with chronic liver diseases, such as hepatitis C. The association of CC with nonalcoholic fatty liver disease (NAFLD) has not been established...
  16. pmc Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
    Andrew S Doré
    Heptares Therapeutics Ltd, BioPark, Welwyn Garden City, Herts, AL7 3AX, UK
    Structure 19:1283-93. 2011
    Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via blockade of adenosine receptors...
  17. pmc TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
    Charalampos Rallis
    Department of Genetics, Evolution and Environment and Institute of Healthy Ageing, University College London, Gower Street Darwin Building, London, WC1E 6BT, UK
    Aging Cell 12:563-73. 2013
    ..Here, we analyzed the effects of rapamycin and caffeine, singly and combined, on multiple cellular processes in fission yeast...
  18. pmc Caffeinated and caffeine-free beverages and risk of type 2 diabetes
    Shilpa N Bhupathiraju
    Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 97:155-66. 2013
    Consumption of caffeinated beverages such as coffee and tea has been associated with a lower risk of type 2 diabetes (T2D). Paradoxically, short-term metabolic studies have shown that caffeine impairs postprandial glycemic control.
  19. doi Prevention of hyperoxia-mediated pulmonary inflammation in neonatal rats by caffeine
    Ulrike Weichelt
    Charité University Medical Centre, Berlin, Germany
    Eur Respir J 41:966-73. 2013
    ..b>Caffeine given to preterm infants for the prevention or treatment of apnoea has been shown to reduce the rate of BPD...
  20. pmc Caffeine intake, smoking, and risk of Parkinson disease in men and women
    Rui Liu
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Am J Epidemiol 175:1200-7. 2012
    The authors prospectively examined whether caffeine intake was associated with lower risk of Parkinson disease (PD) in both men and women among 304,980 participants in the National Institutes of Health-AARP Diet and Health Study and ..
  21. ncbi Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways
    Zhiwei He
    Hormel Institute, University of Minnesota, 801 16th Avenue N E, Austin, MN 55912, USA
    Cancer Res 63:4396-401. 2003
    b>Caffeine is a key component of many popular drinks, especially tea and coffee. Previous reports have shown that caffeine may contribute to the chemopreventive effect of tea in animals...
  22. ncbi The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults
    Hiroyasu Iso
    Public Health, Department of Social and Environmental Health, Osaka University and Osaka City University, Suita Shi, Osaka, Japan
    Ann Intern Med 144:554-62. 2006
    ..In western populations, coffee consumption is associated with a reduced risk for type 2 diabetes; however, the effect of green, black, and oolong teas is unclear...
  23. pmc Use of a prescribed ephedrine/caffeine combination and the risk of serious cardiovascular events: a registry-based case-crossover study
    Jesper Hallas
    Department of Clinical Pharmacology, Faculty of Health Sciences, University of Southern Denmark, DK 5000 Odense C, Denmark
    Am J Epidemiol 168:966-73. 2008
    ..There have been no large controlled studies on the possible association between prescribed ephedrine/caffeine and cardiovascular events in general...
  24. doi Use of coffee, caffeinated drinks and caffeine tablets for cognitive enhancement in pupils and students in Germany
    A G Franke
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Mainz, Germany
    Pharmacopsychiatry 44:331-8. 2011
    ..There are only few data about substances, prevalence rates and factors associated with CE. The aim of this study was to assess first data about the use of coffee, caffeinated drinks and caffeine tablets for CE at school and university.
  25. doi The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis
    R Hursel
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Obes Rev 12:e573-81. 2011
    Different outcomes of the effect of catechin-caffeine mixtures and caffeine-only supplementation on energy expenditure and fat oxidation have been reported in short-term studies...
  26. pmc Caffeine attenuates lipopolysaccharide-induced neuroinflammation
    Holly m Brothers
    Department of Psychology, Ohio State University, Columbus, OH 43210, United States
    Neurosci Lett 480:97-100. 2010
    b>Caffeine is an antagonist at A1 and A2A adenosine receptors and epidemiological evidence suggests that caffeine consumption reduces the risk of Alzheimer's and Parkinson's diseases...
  27. ncbi Coffee and health: a review of recent human research
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 46:101-23. 2006
    Coffee is a complex mixture of chemicals that provides significant amounts of chlorogenic acid and caffeine. Unfiltered coffee is a significant source of cafestol and kahweol, which are diterpenes that have been implicated in the ..
  28. pmc Positive effects of Red Bull® Energy Drink on driving performance during prolonged driving
    Monique A J Mets
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P O BOX 80082, 3508 TB, Utrecht, The Netherlands
    Psychopharmacology (Berl) 214:737-45. 2011
    ..The purpose of this study was to examine if Red Bull® Energy Drink can counteract sleepiness and driving impairment during prolonged driving...
  29. ncbi The effects of red bull energy drink on human performance and mood
    C Alford
    Psychology Department, University of the West of England, Bristol, United Kingdom
    Amino Acids 21:139-50. 2001
    The effects of Red Bull Energy Drink, which includes taurine, glucuronolactone, and caffeine amongst the ingredients, were examined over 3 studies in a total of 36 volunteers...
  30. ncbi Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users
    Emma Childs
    The University of Chicago, 5841 S Maryland Avenue, MC3077, Chicago, IL 60637, USA
    Psychopharmacology (Berl) 185:514-23. 2006
    b>Caffeine produces mild psychostimulant effects that are thought to underlie its widespread use. However, the direct effects of caffeine are difficult to evaluate in regular users of caffeine because of tolerance and withdrawal...
  31. pmc Pharmacological profiling of the Dictyostelium adenylate cyclases ACA, ACB and ACG
    Elisa Alvarez-Curto
    School of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Biochem J 401:309-16. 2007
    ..b>Caffeine, which was previously used to specifically block ACA function, also inhibited cAMP accumulation by ACB and ACG...
  32. ncbi Well-trained endurance athletes' knowledge, insight, and experience of caffeine use
    Ben Desbrow
    School of Public Health and Heart Foundation Research Centre, Griffith University, Gold Coast, Queensland, Australia
    Int J Sport Nutr Exerc Metab 17:328-39. 2007
    This descriptive cross-sectional study assessed the perceptions, knowledge, and experiences of caffeine use by athletes competing at the 2005 Ironman Triathlon World Championships...
  33. ncbi Effects of caffeine ingestion on exercise testing: a meta-analysis
    Mike Doherty
    Dept of Sport, Exercise and Biomedical Sciences, University of Luton, Beds LU1 3JU, UK
    Int J Sport Nutr Exerc Metab 14:626-46. 2004
    This study used the meta-analytic approach to examine the effects of caffeine ingestion on exercise testing. Forty double-blind studies with 76 effect sizes (ES) met the inclusion criteria...
  34. doi Artificial sweeteners, caffeine, and alcohol intoxication in bar patrons
    Matthew E Rossheim
    Department of Behavioral Science and Community Health, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA
    Alcohol Clin Exp Res 35:1891-6. 2011
    ..Studies conducted in natural drinking settings, such as bars, have indicated that caffeine ingestion while drinking is associated with higher levels of intoxication...
  35. pmc Mechanism of Mpk1 mitogen-activated protein kinase binding to the Swi4 transcription factor and its regulation by a novel caffeine-induced phosphorylation
    Andrew W Truman
    Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Mol Cell Biol 29:6449-61. 2009
    ..Finally, we show that caffeine is an atypical activator of cell wall integrity signaling, because it induces phosphorylation of the Mpk1 C-..
  36. ncbi Association of coffee and caffeine intake with the risk of Parkinson disease
    G W Ross
    Department of Veterans Affairs, Honolulu 151, PO Box 50188, Honolulu, HI 96850, USA
    JAMA 283:2674-9. 2000
    ..The projected expansion in the next several decades of the elderly population at highest risk for Parkinson disease (PD) makes identification of factors that promote or prevent the disease an important goal...
  37. ncbi Differential effects of psychomotor stimulants on attentional performance in rats: nicotine, amphetamine, caffeine and methylphenidate
    L Bizarro
    Section of Behavioural Pharmacology, Institute of Psychiatry P049, King s College London, UK
    Behav Pharmacol 15:195-206. 2004
    ..This study compared the effects of nicotine, amphetamine, caffeine and methylphenidate on performance in the 5-CSRTT and determined whether presenting stimuli at unpredictable ..
  38. pmc ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation
    P Nghiem
    Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 98:9092-7. 2001
    ..This lethal event is prevented by a highly conserved checkpoint involving an unknown, caffeine-sensitive mediator...
  39. ncbi A taste receptor required for the caffeine response in vivo
    Seok Jun Moon
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Curr Biol 16:1812-7. 2006
    b>Caffeine is a methylxanthine present in the coffee tree, tea plant, and other naturally occurring sources and is among the most commonly consumed drugs worldwide...
  40. pmc Multiple gustatory receptors required for the caffeine response in Drosophila
    Youngseok Lee
    Department of Biological Chemistry, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:4495-500. 2009
    ..The only insect gustatory receptor shown to be required for avoiding noxious compounds is the Drosophila caffeine receptor, Gr66a...
  41. doi Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters
    Melanie A Heckman
    Dept of Food Science and Human Nutrition, Univ of Illinois Urbana Champaign, IL, USA
    J Food Sci 75:R77-87. 2010
    b>Caffeine ranks as one of the top most commonly consumed dietary ingredients throughout the world. It is naturally found in coffee beans, cacao beans, kola nuts, guarana berries, and tea leaves including yerba mate...
  42. ncbi Improved cycling time-trial performance after ingestion of a caffeine energy drink
    John L Ivy
    Department of Kinesiology and Health Education, University of Texas, Austin, TX 78712 0360, USA
    Int J Sport Nutr Exerc Metab 19:61-78. 2009
    ..Energy drinks are composed of ingredients that have been found to increase endurance and improve physical performance...
  43. doi Effect of caffeine on sport-specific endurance performance: a systematic review
    Matthew S Ganio
    Department of Kinesiology, Human Performance Laboratory, University of Connecticut, Storrs, Connecticut, USA
    J Strength Cond Res 23:315-24. 2009
    Endurance athletes often ingest caffeine because of its reported ergogenic properties...
  44. pmc Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety
    Emma Childs
    Department of Psychiatry, The University of Chicago, Chicago, IL 60657, USA
    Neuropsychopharmacology 33:2791-800. 2008
    b>Caffeine produces mild psychostimulant and sometimes anxiogenic effects by antagonizing adenosine at A(1) and A(2A) receptors, and perhaps through interactions with other transmitter systems...
  45. ncbi Prospective study of caffeine consumption and risk of Parkinson's disease in men and women
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Neurol 50:56-63. 2001
    ..To address the hypothesis that caffeine is protective against Parkinson's disease, we examined the relationship of coffee and caffeine consumption to the ..
  46. doi Caffeine and anaerobic performance: ergogenic value and mechanisms of action
    J K Davis
    Department of Health and Human Performance, Texas A and M University Commerce, Commerce, Texas, USA
    Sports Med 39:813-32. 2009
    The effect caffeine elicits on endurance performance is well founded. However, comparatively less research has been conducted on the ergogenic potential of anaerobic performance...
  47. ncbi Gastrointestinal function during exercise: comparison of water, sports drink, and sports drink with caffeine
    M A van Nieuwenhoven
    Department of Gastroenterology, University Hospital, Maastricht, 6202 AZ Maastricht, The Netherlands
    J Appl Physiol (1985) 89:1079-85. 2000
    b>Caffeine is suspected to affect gastrointestinal function...
  48. doi Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway
    Paula M Canas
    Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurosci 29:14741-51. 2009
    ..b>Caffeine consumption prevents memory dysfunction in different models, which is mimicked by antagonists of adenosine A(2A) ..
  49. doi Functional analysis of the cis-acting elements responsible for the induction of the Cyp6a8 and Cyp6g1 genes of Drosophila melanogaster by DDT, phenobarbital and caffeine
    R Morra
    Department of Biology, Emory University, Atlanta, GA, USA
    Insect Mol Biol 19:121-30. 2010
    Many Drosophila cytochrome P450 or Cyp genes are induced by caffeine and phenobarbital (PB)...
  50. doi Caffeine enhances osteoclast differentiation and maturation through p38 MAP kinase/Mitf and DC-STAMP/CtsK and TRAP pathway
    Jiwon Choi
    Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan Si, Chungnam 336 745, Republic of Korea
    Cell Signal 25:1222-7. 2013
    The consumption of caffeine from some common beverages has been associated with low bone mass by inducing urinary calcium loss and deceasing bone mineral density...
  51. ncbi Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice
    Oscar P Dall'Igna
    Departamento de Bioquimica, ICBS, UFRGS, Porto Alegre, Brazil
    Exp Neurol 203:241-5. 2007
    Consumption of caffeine, an adenosine receptor antagonist, was found to be inversely associated with the incidence of Alzheimer's disease...
  52. doi Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice
    Rohit A Sinha
    Program of Cardiovascular and Metabolic Disorders, Duke NUS Graduate Medical School, Singapore
    Hepatology 59:1366-80. 2014
    b>Caffeine is one of the world's most consumed drugs...
  53. pmc Coffee, caffeine, and risk of depression among women
    Michel Lucas
    Department of Nutrition, Harvard School of Public Health, and Department of Medicine, Brigham and Women s Hospital, 655 Huntington Ave, Boston, MA 02115, USA
    Arch Intern Med 171:1571-8. 2011
    b>Caffeine is the world's most widely used central nervous system stimulant, with approximately 80% consumed in the form of coffee...
  54. pmc The enigmatic effects of caffeine in cell cycle and cancer
    Ann M Bode
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Lett 247:26-39. 2007
    b>Caffeine may very well be the most frequently ingested neuroactive drug in the world...
  55. pmc A prospective cohort study of coffee consumption and risk of endometrial cancer over a 26-year follow-up
    Youjin Je
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:2487-95. 2011
    ..Coffee has been reported to lower levels of estrogen and insulin, two hormones implicated in endometrial carcinogenesis, but prospective data on the relation between coffee consumption and risk of endometrial cancer are limited...
  56. pmc Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A
    Sandrine Turpault
    Global Metabolism and Pharmacokinetics, Sanofi Aventis, Malvern, PA, USA
    Br J Clin Pharmacol 68:928-35. 2009
  57. doi Caffeine consumption and cognitive function at age 70: the Lothian Birth Cohort 1936 study
    Janie Corley
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK
    Psychosom Med 72:206-14. 2010
    To investigate the association between caffeine consumption and cognitive outcomes in later life.
  58. pmc Caffeine reduces the activation extent and contrast-to-noise ratio of the functional cerebral blood flow response but not the BOLD response
    Joy Liau
    Center for Functional Magnetic Resonance Imaging and Department of Radiology, University of California San Diego, La Jolla, CA, USA
    Neuroimage 42:296-305. 2008
    ..In this study, we used a caffeine dose (200 mg) to decrease baseline CBF and found significant (p<0...
  59. doi Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis
    Olivia J Phung
    University of Connecticut School of Pharmacy, Storrs, CT, USA
    Am J Clin Nutr 91:73-81. 2010
    Green tea catechins (GTCs) with or without caffeine have been studied in randomized controlled trials (RCTs) for their effect on anthropometric measures and have yielded conflicting results.
  60. ncbi Caffeine content of specialty coffees
    Rachel R McCusker
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, P O Box 100275, Gainesville, Florida 32610 0275, USA
    J Anal Toxicol 27:520-2. 2003
    b>Caffeine is the world's most widely consumed drug with its main source found in coffee. We evaluated the caffeine content of caffeinated and decaffeinated specialty coffee samples obtained from coffee shops...
  61. doi Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats
    Guo Qian Chen
    Department of Neurology, the First Affiliated Hospital and Research Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, Zhejiang, PR China
    Brain Res 1309:116-25. 2010
    ..b>Caffeine, a non-selective antagonist of adenosine receptors, has been shown to provide protection against myelin ..
  62. doi Chemical and nutritional composition of tejate, a traditional maize and cacao beverage from the Central Valleys of Oaxaca, Mexico
    Angela Sotelo
    Departamento de Farmacia, Facultad de Quimica, Laboratorio 111, Universidad Nacional Autonoma de Mexico, 04510 Mexico, DF, Mexico
    Plant Foods Hum Nutr 67:148-55. 2012
    ..Its substitution by sodas and other high glycemic beverages may have negative nutritional, health and cultural consequences...
  63. ncbi Habitual caffeine intake and the risk of hypertension in women
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    JAMA 294:2330-5. 2005
    b>Caffeine acutely increases blood pressure, but the association between habitual consumption of caffeinated beverages and incident hypertension is uncertain.
  64. ncbi Coffee, tea and diabetes: the role of weight loss and caffeine
    J A Greenberg
    Department of Health and Nutrition Sciences, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA
    Int J Obes (Lond) 29:1121-9. 2005
    ..To assess the effect of weight change on the relationship between coffee and tea consumption and diabetes risk...
  65. doi Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women
    Shino Oba
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu1 1 Yanagido, Gifu, Gifu 501 1194, Japan
    Br J Nutr 103:453-9. 2010
    ..inverse association between coffee consumption and risk of diabetes has been reported numerous times, the role of caffeine intake in this association has remained unclear...
  66. doi Caffeine improves supramaximal cycling but not the rate of anaerobic energy release
    Michael J Simmonds
    School of Physiotherapy and Exercise Science, Gold Coast Campus, Griffith University, Southport, QLD 4215, Australia
    Eur J Appl Physiol 109:287-95. 2010
    ..of this study was to determine if improved supramaximal exercise performance in trained cyclists following caffeine ingestion was associated with enhanced O(2) uptake (VO2 kinetics), increased anaerobic energy provision (..
  67. pmc Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine
    Wesley D Block
    Department of Biological Sciences, Cancer Biology Research Group, University of Calgary, 3330 Hospital Drive N W, Calgary AB, T2N 4N1, Canada
    Nucleic Acids Res 32:1967-72. 2004
    b>Caffeine inhibits cell cycle checkpoints, sensitizes cells to ionizing radiation-induced cell killing and inhibits the protein kinase activity of two cell cycle checkpoint regulators, Ataxia-Telangiectasia mutated (ATM) and ATM- and Rad3-..
  68. pmc The metabolic and performance effects of caffeine compared to coffee during endurance exercise
    Adrian B Hodgson
    Human Performance Laboratory, School of Sport and Exercise Science, University of Birmingham, Birmingham, United Kingdom
    PLoS ONE 8:e59561. 2013
    There is consistent evidence supporting the ergogenic effects of caffeine for endurance based exercise. However, whether caffeine ingested through coffee has the same effects is still subject to debate...
  69. ncbi Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States
    Constance E Ruhl
    Social and Scientific Systems Inc, 8758 Georgia Avenue, Silver Spring, MD 20910, USA
    Gastroenterology 128:24-32. 2005
    Based on experimental and epidemiologic studies, we investigated whether coffee and caffeine consumption reduced the risk of elevated alanine aminotransferase (ALT) activity in persons at high risk for liver injury in a national, ..
  70. ncbi Cognitive and physiological effects of an "energy drink": an evaluation of the whole drink and of glucose, caffeine and herbal flavouring fractions
    Andrew B Scholey
    Human Cognitive Neuroscience Unit, Division of Psychology, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
    Psychopharmacology (Berl) 176:320-30. 2004
    Both glucose and caffeine can improve aspects of cognitive performance and, in the case of caffeine, mood. There are few studies investigating the effects of the two substances in combination.
  71. pmc Energy beverages: content and safety
    John P Higgins
    Division of Cardiology, Lyndon B Johnson General Hospital, and Memorial Hermann Sports Medicine Institute, The University of Texas Medical School at Houston, Houston, TX 77026 1967, USA
    Mayo Clin Proc 85:1033-41. 2010
    ..from 1976 through May 2010, using the following keywords: energy beverage, energy drink, power drink, exercise, caffeine, red bull, bitter orange, glucose, ginseng, guarana, and taurine...
  72. pmc The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression
    Katsuhiro Nagatomo
    Division of Biophysics and Neurobiology, National Institute for Physiological Sciences, Graduate University for Advanced Studies, Aichi, Japan
    Biophys J 99:3609-18. 2010
    ..We recently reported that caffeine activates mouse TRPA1 (mTRPA1) but suppresses human TRPA1 (hTRPA1)...
  73. pmc Tea and coffee intake in relation to risk of breast cancer in the Black Women's Health Study
    Deborah A Boggs
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Cancer Causes Control 21:1941-8. 2010
    ..We prospectively examined the relation of tea and coffee consumption to risk of breast cancer among 52,062 women aged 21-69 at enrollment in 1995 in the Black Women's Health Study...
  74. ncbi Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells
    Takashi Hashimoto
    Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 64:3344-9. 2004
    b>Caffeine is a major biologically active constituent in coffee and tea. Because caffeine has been reported to inhibit carcinogenesis in UVB-exposed mice, the cancer-preventing effect of caffeine has attracted considerable attention...
  75. doi Caffeine withdrawal and high-intensity endurance cycling performance
    Christopher Irwin
    School of Public Health, Griffith University, Gold Coast, Queensland, Australia
    J Sports Sci 29:509-15. 2011
    In this study, we investigated the impact of a controlled 4-day caffeine withdrawal period on the effect of an acute caffeine dose on endurance exercise performance...
  76. ncbi Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice
    Yao Ping Lu
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ 08854 8020, USA
    Cancer Res 64:5020-7. 2004
    ..Topical applications of caffeine immediately after UVB irradiation in female p53(+/+) or p53(-/-) mice enhanced the UVB-induced increase in ..
  77. ncbi Alcohol and caffeine consumption and decreased fertility
    R B Hakim
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Fertil Steril 70:632-7. 1998
    To examine the effects of alcohol and caffeine on conception.
  78. doi Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress
    Xiongwen Lv
    School of Pharmacy, Anhui Medical University, Shushan District, Hefei, China
    Inflamm Res 59:635-45. 2010
    The present investigation was designed to determine the effects of caffeine on alcohol-induced hepatic injury in mice.
  79. doi Oxidative stress parameters in rats exposed to fluoride and caffeine
    I Inkielewicz-Stepniak
    Department of Toxicology, Medical University of Gdansk, Gdansk, Poland
    Food Chem Toxicol 48:1607-11. 2010
    In our experiment, the 1-month effects of caffeine (Caff) and fluoride (F) administered separately and together on nitric oxide and total antioxidant status in serum, brain, liver and kidney of rats were investigated...
  80. pmc Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer
    Karin B Michels
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 97:282-92. 2005
    ..Cohort studies have not revealed such an association but were limited in size. We explored the association between consumption of coffee and tea and the incidence of colorectal cancer in two large prospective cohorts of women and men...
  81. doi Caffeine and uric acid mediate glutathione synthesis for neuroprotection
    K Aoyama
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi, Tokyo 173 8501, Japan
    Neuroscience 181:206-15. 2011
    Several lines of epidemiological studies have indicated that caffeine consumption and plasma uric acid (UA) level were negatively correlated with the incidence of some neurodegenerative diseases...
  82. ncbi Caffeine ingestion is associated with reductions in glucose uptake independent of obesity and type 2 diabetes before and after exercise training
    SoJung Lee
    School of Physical and Health Education, Queen s University, Kingston, Ontario, Canada, K7L 3N6
    Diabetes Care 28:566-72. 2005
    We investigated the effect of caffeine ingestion on insulin sensitivity in sedentary lean men (n = 8) and obese men with (n = 7) and without (n = 8) type 2 diabetes...
  83. ncbi ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
    C A Hall-Jackson
    Department of Biochemistry, University of Dundee, Scotland, UK
    Oncogene 18:6707-13. 1999
    ..Finally, we find that the kinase activity of ATR in the presence and absence of DNA is suppressed by caffeine, a compound which is known to induce loss of checkpoint control...
  84. doi Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes
    G K McConell
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Appl Physiol (1985) 108:589-95. 2010
    5-Aminoimidazole-4-carboxamide-ribonucleoside (AICAR) and caffeine, which activate AMP-activated protein kinase (AMPK) and cause sarcoplasmic reticulum calcium release, respectively, have been shown to increase mitochondrial biogenesis in ..
  85. doi Nonventilatory strategies for prevention and treatment of bronchopulmonary dysplasia--what is the evidence?
    W Thomas
    University Children s Hospital, Wurzburg, Germany
    Neonatology 94:150-9. 2008
    ..Early administration of caffeine seems to confer a benefit with regard to BPD...
  86. pmc Sociodemographic correlates of energy drink consumption with and without alcohol: results of a community survey
    Lisa K Berger
    Center for Addiction and Behavioral Health Research, Helen Bader School of Social, Welfare, University of Wisconsin Milwaukee, 2400 E Hartford Avenue, Milwaukee, WI 53211, USA
    Addict Behav 36:516-9. 2011
    ..We examined the sociodemographic correlates of energy drink use and the differences between those who use them with and without alcohol in a representative community sample...
  87. ncbi Effect of different protocols of caffeine intake on metabolism and endurance performance
    Gregory R Cox
    Sports Science and Sports Medicine, Australian Institute of Sport, Belconnen, Australian Capital Territory 2616, Australia
    J Appl Physiol 93:990-9. 2002
    ..In Study A, 12 subjects received either 6 mg/kg caffeine 1 h preexercise (Precaf), 6 x 1 mg/kg caffeine every 20 min throughout SS (Durcaf), 2 x 5 ml/kg Coca-Cola between ..
  88. ncbi Three independent mechanisms for arrest in G2 after ionizing radiation
    Kirsti Solberg Landsverk
    Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Cell Cycle 10:819-29. 2011
    ..6 hours after IR) of cells that were in G(2)/S/G(1) at the time of irradiation (4 Gy) was inactivated by caffeine. This late G(2)-arrest could not be explained by down-regulation of genes with functions in G(2)/mitosis (e.g...
  89. ncbi Effects of energy drink ingestion on alcohol intoxication
    Sionaldo Eduardo Ferreira
    Department of Psychobiology, Federal University of Sao Paulo UNIFESP, the FAPESP fellowship, Sao Paulo SP, Brasil
    Alcohol Clin Exp Res 30:598-605. 2006
    ..Well-known reports suggest that the use of energy drinks might reduce the intensity of the depressant effects of alcohol. However, there is little scientific evidence to support this hypothesis...
  90. ncbi Challenging sleep in aging: the effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers
    Caroline Drapeau
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, QC, Canada
    J Sleep Res 15:133-41. 2006
    The aim of this study was to evaluate the effects of a 200-mg administration of caffeine on polysomnographic sleep variables and quantitative sleep electroencephalography (EEG) in 12 young (20-30 years) and 12 middle-aged (40-60 years) ..
  91. doi Effects of caffeine on daytime recovery sleep: A double challenge to the sleep-wake cycle in aging
    Julie Carrier
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Que, Canada
    Sleep Med 10:1016-24. 2009
    b>Caffeine is the most widely used stimulant to counteract the effects of sleepiness, but it also produces important detrimental effects on subsequent sleep, especially when sleep is initiated at a time when the biological clock sends a ..
  92. ncbi Effect of caffeine on perceptions of leg muscle pain during moderate intensity cycling exercise
    Robert W Motl
    University of Georgia, Department of Exercise Science, University of Georgia, Athens, GA 30602 6554, USA
    J Pain 4:316-21. 2003
    This double-blind, within-subjects experiment examined the effect of ingesting a large dose of caffeine on perceptions of leg muscle pain during moderate intensity cycling exercise...
  93. ncbi Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers
    M Tarnopolsky
    Department of Neurology and Rehabilitation Medicine and Kinesiology, McMaster University Medical Center, Hamilton, Ontario L8N 3Z5, Canada
    J Appl Physiol (1985) 89:1719-24. 2000
    The mechanism of action underlying the ergogenic effect of caffeine is still unclear. Caffeine increases the force of muscular contraction during low-frequency stimulation by potentiating calcium release from the sarcoplasmic reticulum...
  94. doi A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: a 2000-2009 update
    Jennifer David Peck
    University of Oklahoma Health Sciences Center, College of Public Health, USA
    Food Chem Toxicol 48:2549-76. 2010
    This review of human studies of caffeine and reproductive health published between January 2000 and December 2009 serves to update the comprehensive review published by Leviton and Cowan (2002)...
  95. pmc Genome-wide screen of genes required for caffeine tolerance in fission yeast
    Isabel A Calvo
    Oxidative Stress and Cell Cycle Group, Universitat Pompeu Fabra, Barcelona, Spain
    PLoS ONE 4:e6619. 2009
    An excess of caffeine is cytotoxic to all eukaryotic cell types. We aim to study how cells become tolerant to a toxic dose of this drug, and the relationship between caffeine and oxidative stress pathways.
  96. ncbi Caffeine analogs: biomedical impact
    J W Daly
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892 0820, USA
    Cell Mol Life Sci 64:2153-69. 2007
    b>Caffeine, widely consumed in beverages, and many xanthine analogs have had a major impact on biomedical research...
  97. ncbi Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor
    Marina Cerrone
    Molecular Cardiology, IRCCS Fondazione S Maugeri, Pavia, Italy
    Circ Res 96:e77-82. 2005
    ..vitro functional characterization of mutant RyR2 channels showed altered behavior on adrenergic stimulation and caffeine administration with enhanced calcium release from the sarcoplasmic reticulum...
  98. pmc Evaluation of the reproductive and developmental risks of caffeine
    Robert L Brent
    Thomas Jefferson University, Alfred I duPont Hospital for Children, Wilmington, Delaware 19899, USA
    Birth Defects Res B Dev Reprod Toxicol 92:152-87. 2011
    A risk analysis of in utero caffeine exposure is presented utilizing epidemiological studies and animal studies dealing with congenital malformation, pregnancy loss, and weight reduction...
  99. ncbi Caffeine increases time to fatigue by maintaining force and not by altering firing rates during submaximal isometric contractions
    B M Meyers
    School of Kinesiology and Health Science, Faculty of Pure and Applied Science, York Univ, Toronto, Ontario, Canada
    J Appl Physiol 99:1056-63. 2005
    b>Caffeine increases time to fatigue [limit of endurance (T(lim))] during submaximal isometric contractions without altering whole muscle activation or neuromuscular junction transmission...
  100. pmc Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study
    Kathryn M Wilson
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Natl Cancer Inst 103:876-84. 2011
    Coffee contains many biologically active compounds, including caffeine and phenolic acids, that have potent antioxidant activity and can affect glucose metabolism and sex hormone levels...
  101. doi Alcohol, drugs, caffeine, tobacco, and environmental contaminant exposure: reproductive health consequences and clinical implications
    J C Sadeu
    Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Crit Rev Toxicol 40:633-52. 2010
    ..Further research using prospective study designs with robust sample sizes are needed to evaluate testable hypotheses that address the relationship between exposure and adverse reproductive health effects...

Research Grants67

  1. Function and regulation of elemental Ca2+ signaling in urethral smooth muscle
    Ronghua Zhuge; Fiscal Year: 2013
    ..causes catecholaminergic polymorphic ventricular tachycardia in human) generates less force when exposed to caffeine, a RyR agonist, and phenylephrine (PE), an alpha1-adrenergic receptor agonist, than in normal RyR2 mice;(3) ..
  2. An internet based prospective study of time to pregnancy
    Elizabeth E Hatch; Fiscal Year: 2013 follow-up questionnaires that collect data on a wide range of factors including alcohol consumption, caffeine intake, body mass index, physical activity and sedentary behavior...
  3. Green tea effects on gene expression in tobacco users
    Joel L Schwartz; Fiscal Year: 2013
    ..provided by applicant): Green tea (GT) is a mixture largely of catechins, which are phenol flavonoids, and caffeine, that has shown efficacy in preventing lung cancer and a large host of other spontaneous and experimentally ..
  4. A novel and powerful C. elegans behavioral model of addiction
    Eric A Engleman; Fiscal Year: 2013
    ..dependent self-exposure to, various psychoactive drugs including cocaine, methamphetamine, ethanol and caffeine. We have found that they also show sensitization, tolerance, cross-sensitization, and cross tolerance after drug ..
    Johanna Lampe; Fiscal Year: 2009
    ..The specific aims are: 1) To test the effect of broccoli and green cabbage (sources of different ITC) on caffeine metabolite ratios (CYP1A2 activity), serum GST-[unreadable], and serum bilirubin (UGT1A1 activity);2) To compare ..
  6. Effects on Caffeine on Adolescent Behavior and Physiology
    Jennifer L Temple; Fiscal Year: 2010
    Americans consume over 15 billion gallons of soda per year;the equivalent of >550 cans per individual. Caffeine use in adolescents has increased by 70% in the past 30 years...
    Martin Morad; Fiscal Year: 2013
    ..AM-loaded and permeabilized cells, confocal imaging show mitochondrial gain of Ca2+ on release of SR Ca2+ by caffeine and a loss of mitochondrial Ca2+ on application of PF pulses...
    Edward Clark; Fiscal Year: 2009
    ..interviews and provided approximately 20 ml of blood for the analysis of HAAs and metabolites of cigarette smoke, caffeine, and dietary supplements. Male partners provided semen samples for an objective assessment of male fecundity...
  9. Impact CYP2D6 Phenotype on Response to Methamphetamine in Humans
    Alison Oliveto; Fiscal Year: 2013
    ..response to METH by testing the behavioral effects of agents that serve as positive (codeine) and negative (caffeine) controls for CYP2D6 phenotype...
  10. Risk Factors for Urinary Incontinence in Women
    Francine Grodstein; Fiscal Year: 2010
    ..on diet and UI in older women;women with incontinence are often given advice to reduce certain foods, such as caffeine, and acidic fruit/vegetables...
  11. Long-term effects of caffeine therapy for apnea of prematurity on sleep disorders
    Carole L Marcus; Fiscal Year: 2012
    ..of a unique cohort of ex-premature, 5-6 year old children who were randomized at birth to receive either caffeine or placebo, and are currently receiving detailed neurocognitive and behavioral assessments (the Caffeine for ..
    Reese T Jones; Fiscal Year: 2013
    ..and its metabolites, cocaine, methamphetamine and other phenethylamines, alcohol, MDMA, ephedra alkaloids, caffeine, gamma hydroxybutyrate (GHB), salvinorin, adenosine, and neurosteroids, and opiates...
  13. Hepatitis C Clinical Trial-Clinical Center
    Jules L Dienstag; Fiscal Year: 2009
    ..liver function tests, serum fibrosis markers, esophageal varices, dietary constituents including coffee and caffeine, health related quality of life and depressive symptoms;validation of fibrosis staging;and biomarkers for HCC.
  14. Nutritional Epidemiology of Lower Urinary Tract Symptoms
    Nancy Nairi Maserejian; Fiscal Year: 2010
    ..of various beverage types are also examined prospectively to verify anecdotal evidence regarding effects of caffeine, acidic or carbonated beverages...
  15. Epidemiology, genetics, and behaviors in a study of basal cell carcinoma
    LEAH MCARTHUR FERRUCCI; Fiscal Year: 2012
    ..level tumor mutations;(2) investigating environmental/lifestyle factors (UV exposure, tanning bed use, and caffeine intake) in relation to BCC;and (3) describing and evaluating indoor and outdoor tanning behaviors ,attitudes, and ..
  16. Pursuing purine pathways to clinical trials for Parkinson's disease
    Michael A Schwarzschild; Fiscal Year: 2012
    ..colleagues have obtained convergent evidence that two ubiquitous purines might reduce the risk of developing PD: caffeine (an adenosine receptor antagonist) and urate (the end product of adenosine metabolism and a major antioxidant in ..
  17. Air pollution and Parkinson disease: a GIS-based approach
    Natalia Palacios; Fiscal Year: 2013
    ..interactions between air pollution and dietary and lifestyle factors including smoking, intake of antioxidants, caffeine intake and use of NSAID anti-inflammatory medications...
  18. Investigating Genetics of Human Natural Short Sleepers
    Ying Hui Fu; Fiscal Year: 2013
    ..including life-style choices, socio-economic status, health, employment, school, and exogenous chemicals like caffeine and alcohol. Sleep and circadian function are distinct processes that interact in living organisms...
  19. Molecular and Clinical Pharmacology of Retinopathy of Prematurity
    Jacob V Aranda; Fiscal Year: 2013
    ..dysregulated angiogenesis and vasoproliferation can be modulated or prevented by synergistic interventions of caffeine and systemic ibuprofen or ocular NSAID local drops...
  20. Feasibility of an internet-based study of time-to-pregnancy in the United States
    Lauren A Wise; Fiscal Year: 2013
    ..Secondarily, it will evaluate several potential risk factors for delayed TTP, including caffeine, anthropometric factors, physical activity, and antidepressant use...
  21. Pharmacogenomics of Parkinson's Disease
    Haydeh Payami; Fiscal Year: 2013
    ..Nicotine and caffeine are neuroprotective in animal models and are robustly associated with reduced risk of PD in humans...
  22. Nonsense-mediated decay array analysis of atypical Werner syndrome
    Junko Oshima; Fiscal Year: 2010
    ..screens will utilize three different NMD inhibitors, emetine (inhibits initial scanning of truncated proteins), caffeine (inhibits SMG1 kinase in the NMD complex combined with actinomycin D), and an RNAi against UFP1 (a component of ..
  23. Analgesic actions of adenosine A1 receptor along axonal tracts in chronic pain
    Takahiro Takano; Fiscal Year: 2013
    ..A1 receptor KO mice will serve as a negative control. Importantly, these experiments will also evaluate whether caffeine (an adenosine receptor antagonist) nullifies acupuncture induced analgesia...
  24. Licit Abused Drugs
    Roland R Griffiths; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Caffeine use may cause or exacerbate anxiety, insomnia, panic attacks, hypertension, urinary incontinence, gastrointestinal disturbance, and problems in pregnancy...
  25. A Nicotine Biosensor for Addiction Studies
    Peter A Petillo; Fiscal Year: 2013
    ..e., cocaine and caffeine)...
  26. Genetic Modification of Triggers of Acute Myocardial Infarction
    ANA B BAYLIN; Fiscal Year: 2011
    ..myocardial infarction by examining genes involved in the sympathetic nervous system, renin-angiotensin system, caffeine metabolism, and genes that mediate some of the physiologic effects of caffeine...
  27. Inhibition of skin cancer by caffeine: Effects on late stages of carcinogenesis
    YAOPING LU; Fiscal Year: 2012
    ..Topical applications of caffeine 5 days a week to these high risk mice inhibited carcinogenesis and selectively increased apoptosis in the tumors ..
  28. Alcohol and Energy Drink Use, Expectancies and Sexual Risk Taking
    Kathleen E Miller; Fiscal Year: 2013
    ..We will control for demographic and personality characteristics as well as other alcohol and/or caffeine use, in order to examine the unique effects of AED use on sexual risk-taking (i.e...
    William Perry; Fiscal Year: 2013
    ..using dopamine agonist compounds (amphetamine and modafinil) and compared to a non-dopaminergic stimulant (caffeine) and placebo...
  30. A Nicotine Biosensor for Addiction Studies
    Peter A Petillo; Fiscal Year: 2012
    ..e., cocaine and caffeine). PUBLIC HEALTH RELEVANCE: It is estimated that 50% of regular smokers die due to smoking-related complications...
  31. Combined effects of alcohol and caffeine on agency judgment, impulsivity and risk
    ADRIENNE JULIE HEINZ; Fiscal Year: 2011
    ..of the proposed research training program is to delineate a clear profile of the conjoint effects of alcohol and caffeine on critical affective, behavioral, and cognitive outcomes in young social drinkers...
  32. Inhibitory effects of caffeine, exercise and lipectomy on UVB-induced skin cancer
    YAOPING LU; Fiscal Year: 2012
    ..Our studies indicated that oral administration of caffeine or voluntary running wheel exercise (a) decreases tissue fat, (b) inhibits UVB-induced skin carcinogenesis, and (..
  33. Dopamine and Unpredicted Alcohol Delivery: Effects of Alcohol Consumption
    Karmen K Yoder; Fiscal Year: 2013
    ..IV alcohol administration will result in a greater magnitude of DA release in NTS compared to SD;(3) Unexpected caffeine administration will result in increases in DA in SD, but not NTS...
  34. Polyphenon E for the Chemoprevention of Colorectal Cancer
    Frank A Sinicrope; Fiscal Year: 2013
    ..Polyphenon E (PPE), a defined green tea polyphenol preparation containing about 65% EGCG and less than 0.1% caffeine, is currently being evaluated in the chemoprevention studies for human cancers...
  35. TAAR1 and the Control of Wakefulness
    Thomas S Kilduff; Fiscal Year: 2013
    ..Lastly, we will determine whether TAAR1 signaling is necessary for the wake-promoting effects of the stimulant caffeine and the wake- promoting therapeutic modafinil (Provigil(R)) and the endogenous wake-promoting neuropeptide, ..
  36. Caffeine regulates splicing of cancer-related genes: dissecting the mechanism
    Kathleen W Scotto; Fiscal Year: 2011
    ..We now present a substantial body of preliminary data showing that caffeine, a highly consumed stimulant in the human diet, induces alternative splicing of a large subset of cancer-related ..
  37. The replication checkpoint and genomic fidelity in skin
    Paul Nghiem; Fiscal Year: 2013
    ..b>Caffeine is the most commonly used inhibitor of this checkpoint and our prior studies have shown promise for caffeine as ..
  38. Cerebellar Function in Health and Disease
    Kamran Khodakhah; Fiscal Year: 2013
    ..often triggered by factors such as emotional or physical stress, or by ingestion of relatively harmless doses of caffeine and ethanol...
  39. Aging microglia-neuronal communication
    Gary L Wenk; Fiscal Year: 2012
    ..Aim 3 will examine the ability of caffeine to restore cytokine balance and promote an anti-inflammatory cytokine profile in young and aged male rats and ..
  40. Synergistic Neuroprotective Mechanisms of Coffee Components in Parkinson's Diseas
    Jeffry B Stock; Fiscal Year: 2013
    ..This association has been attributed to caffeine, but coffee is much more than just caffeine and the finding that caffeine may be neuroprotective in no way ..
    George Bigelow; Fiscal Year: 2013
    ..Training includes a broad range of abused drug classes - opioids, cocaine, prescription medications, cannabis, club drugs, alcohol, tobacco/nicotine, and caffeine.
  42. Caffeine-induced modulation of GABAergic transmission
    Masako Isokawa; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Caffeine is the world's most popular psychoactive drug and a powerful modulator of excitability in the brain...
  43. NAD & CD38 Form a Communication System in the Retina
    Robert Miller; Fiscal Year: 2006
    ..Activation of ryanodine receptors triggers calcium waves which can be blocked or modified by ryanodine, caffeine and thapsigargin, the latter of which depletes internal calcium stores...
    John Fink; Fiscal Year: 2000
    ..disorder characterized by attacks of involuntary movements that occur spontaneously at rest and often following caffeine or alcohol consumption. The cause of PDC is unknown and treatments are generally unsatisfactory...
  45. Impulsivity and Stimulant Drug Reward
    Jessica Weafer; Fiscal Year: 2013
    ..5 mg/kg), and caffeine (0-200 mg) in individuals high and low on each of the sub-components of impulsivity...
    Daniel Cramer; Fiscal Year: 2002
    ..Key exposure examined in men and women included caffeine, alcohol, and tobacco. In women, smoking was the principal exposure that decreased number of eggs retrieved...
    JARVIS CHAN; Fiscal Year: 1990
    ..Ingested caffeine is readily absorbed and present in breast milk...
  48. Gender Differences in Responses to Caffeine in Children and Adolescents
    Jennifer L Temple; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Caffeine is the most widely used psychoactive substance in the world and its use is increasing among children...
  49. Molecular Mechanisms of PDE5 Regulation
    Jackie Corbin; Fiscal Year: 2005
    ..Therapeutic agents that elevate cGMP include PDE inhibitors (e.g., caffeine, papaverine, and sildenafil) and nitrovasodilators (e.g., nitroglycerin)...
    JEFFRY LANSMAN; Fiscal Year: 2000
    ..indicate the involvement of ryanodine receptors in this phenomenon: Current oscillations can be initiated by caffeine and ryanodine and ruthenium red block current oscillations initiated by either caffeine or t-ACPD...
    Frank Holloway; Fiscal Year: 1992
    ..The present proposal would extend the analysis of these legal stimulant combinations (e.g., caffeine (CAF), ephedrine (EPH), and phenylpropanolamine (PPA))...
    DARRAGH DEVINE; Fiscal Year: 2002
    ..One model is the chronic methylxanthine model, in which caffeine (an adenosine receptor antagonist) is administered to rats for 10 to 12 days...
    Keith Lillemoe; Fiscal Year: 1993
    ..In this proposal, we will define the role of dietary calcium and caffeine, two important components of the American diet, in pathogenesis and prevention of gallstones...
    Gayle Windham; Fiscal Year: 2001
    ..menarche, and its relationship to prenatal exposure to chemical substances including, tobacco smoke, alcohol and caffeine (TAC)...
    Maureen Hatch; Fiscal Year: 1993 women workers and to study effects of physical and mental job stress, and stress-related behaviors like caffeine consumption, on cycle characteristics and ovarian hormone patterns...
  56. Alcohol and Acetaminophen Hepatotoxicity
    Jacqueline Sinclair; Fiscal Year: 2006
    ..The widely consumed chemicals caffeine and theophylline enhance the activity of CYP3A, and thus have the potential to augment alcohol-mediated APAP ..
  57. The effects of caffeine and caffeine withdrawal on mood, cognition, and fMRI.
    MERIDETH ADDICOTT; Fiscal Year: 2009
    b>Caffeine is a widely used neurostimulant that is found in many foods and beverages such as coffee, tea, soft drinks, and chocolate...
    James Henry; Fiscal Year: 1980
    ..As many as 20% of males die in uremia by 6-9 months. In studies of 15 colonies we hve established that caffeine even at a dose of 3 mg/kg/day will lead to an increased incidence of renal disease in socially stressed mice, but ..
    Leonard Howell; Fiscal Year: 1993
    b>Caffeine and related methylanthines are behaviorally-active drugs used clinically as respiratory stimulants, but biochemical mechanisms that mediate the behavioral and respiratory effects remain undefined...
    Robert Branch; Fiscal Year: 2004
    ..of whole body activity for drug metabolizing enzymes using the Pittsburgh cocktail that comprises CYP1A2 (caffeine), CYP2C19 (S-mephenytoin), CYP2D6 (debrisoquine), CYP2E1 (chlorzoxazone) and CYP3A4 (dapsone), as well as mRNA ..