Genomes and Genes
Summary: 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.
Publications363 found, 100 shown here
- nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamineK Maundrell
Sclavo Research Centre, Siena, Italy
J Biol Chem 265:10857-64. 1990..By contrast, in minimal medium supplemented with thiamine at a concentration of 0.5 microM or greater the transcript is undetectable...
- Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetesN Karachalias
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, UK
Diabetologia 53:1506-16. 2010The aim of this study was to quantify protein damage by glycation, oxidation and nitration in a rat model of diabetes at the sites of development of microvascular complications, including the effects of thiamine and benfotiamine therapy.
- Vitamin B1 functions as an activator of plant disease resistanceIl Pyung Ahn
School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul 151 742, Korea
Plant Physiol 138:1505-15. 2005Vitamin B(1) (thiamine) is an essential nutrient for humans. Vitamin B(1) deficiency causes beriberi, which disturbs the central nervous and circulatory systems...
- Genome-wide association analysis identifies a mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan Husky encephalopathyKaren M Vernau
University of California Davis, Davis, California, United States of America
PLoS ONE 8:e57195. 2013..SLC19A3 was identified as a positional candidate gene. This gene controls the uptake of thiamine in the CNS via expression of the thiamine transporter protein THTR2...
- The potential role of thiamine (vitamin B1) in diabetic complicationsPaul J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
Curr Diabetes Rev 1:287-98. 2005..This pathway is impaired in experimental and clinical diabetes by mild thiamine deficiency...
- Thiamine in plants: aspects of its metabolism and functionsAymeric Goyer
Department of Botany and Plant Pathology, Oregon State University, Hermiston, OR 97838, USA
Phytochemistry 71:1615-24. 2010b>Thiamine diphosphate (vitamin B(1)) plays a fundamental role as an enzymatic cofactor in universal metabolic pathways including glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle...
- Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical studyH Stracke
Medical Clinic und Policlinic III, University Hospital Giessen and Marburg, Location Giessen, Germany
Exp Clin Endocrinol Diabetes 116:600-5. 2008..Efficacy and safety of benfotiamine in treatment of diabetic polyneuropathy...
- Antioxidant properties of thiamineP I Lukienko
Laboratory of Biochemical Pharmacology, Institute of Biochemistry, Belarussian Academy of Sciences, Minsk
Bull Exp Biol Med 130:874-6. 2000b>Thiamine (10(-4)-10(-6)M) inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Thiamine interacts with free radicals and hydroperoxides and is oxidized to thiochrome and thiamine disulfide...
- Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthaseAbhishek Chatterjee
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
Nature 478:542-6. 2011b>Thiamine pyrophosphate 1 is an essential cofactor in all living systems. Its biosynthesis involves the separate syntheses of the pyrimidine 2 and thiazole 3 precursors, which are then coupled...
- Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cellsMarjorie Gangolf
GIGA Neurosciences, University of Liege, Liege, Belgium
PLoS ONE 5:e13616. 2010b>Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism...
- Vitamin B1-induced priming is dependent on hydrogen peroxide and the NPR1 gene in ArabidopsisIl Pyung Ahn
National Institute of Agricultural Biotechnology, Suwon 441 100, Korea
Plant Physiol 143:838-48. 2007b>Thiamine confers systemic acquired resistance (SAR) on susceptible plants through priming, leading to rapid counterattack against pathogen invasion and perturbation of disease progress...
- Molecular characterization of the thi3 gene involved in thiamine biosynthesis in Zea mays: cDNA sequence and enzymatic and structural properties of the recombinant bifunctional protein with 4-amino-5-hydroxymethyl-2-methylpyrimidine (phosphate) kinase andMaria Rapala-Kozik
Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387 Krakow, Poland
Biochem J 408:149-59. 2007A thiamine biosynthesis gene, thi3, from maize Zea mays has been identified through cloning and sequencing of cDNA and heterologous overexpression of the encoded protein, THI3, in Escherichia coli...
- Postpartum thiamine deficiency in a Karen displaced populationR McGready
Shoklo Malaria Research Unit, Mae Sot, Thailand
Am J Clin Nutr 74:808-13. 2001..OBJECTIVE: This study aimed to document thiamine status in the peripartum period to examine the current supplementation program and the correlation between the ..
- Outbreak of beriberi in a prison in Côte d'IvoireLaurence Ahoua
Epicentre, 42 boulevard Richard Lenoir, Paris 75011, France
Food Nutr Bull 28:283-90. 2007..A beriberi outbreak occurred in the Maison d'Arrêt et de Correction d'Abidjan (MACA), a detention center in Abidjan, Côte d'Ivoire, between October 2002 and April 2003...
- Thiamin confers enhanced tolerance to oxidative stress in ArabidopsisMeral Tunc-Ozdemir
Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada 89557, USA
Plant Physiol 151:421-32. 2009..Taken together, our studies suggest that thiamin and TPP function as important stress-response molecules that alleviate oxidative stress during different abiotic stress conditions...
- Thiamine biosynthesis in algae is regulated by riboswitchesMartin T Croft
Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom
Proc Natl Acad Sci U S A 104:20770-5. 2007In bacteria, many genes involved in the biosynthesis of cofactors such as thiamine pyrophosphate (TPP) are regulated by ribo switches, regions in the 5' end of mRNAs to which the cofactor binds, thereby affecting translation and/or ..
- High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular diseaseP J Thornalley
Department of Biological Sciences, University of Essex, Colchester, Essex, UK
Diabetologia 50:2164-70. 2007To assess thiamine status by analysis of plasma, erythrocytes and urine in type 1 and type 2 diabetic patients and links to markers of vascular dysfunction.
- The structural and biochemical foundations of thiamin biosynthesisChristopher T Jurgenson
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Annu Rev Biochem 78:569-603. 2009..Thiamin can also be transported into the cell and can be salvaged through several routes. In addition, two thiamin degrading enzymes have been characterized, one of which is linked to a novel salvage pathway...
- Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactorsLucien Bettendorff
GIGA Neurosciences, University of Liege, Belgium
FEBS J 276:2917-25. 2009..coli, but the mechanism of ThTP synthesis remains elusive. The data reviewed here illustrate the complexity of thiamin biochemistry, which is not restricted to the cofactor role of ThDP...
- A putative thiamine transport protein is a receptor for feline leukemia virus subgroup ARamon Mendoza
Program in Molecular and Cellular Biology, University of Washington, Seattle, USA
J Virol 80:3378-85. 2006..The feline cDNA shares approximately 93% amino acid sequence identity with the human thiamine transport protein 1 (THTR1)...
- Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expressionWade Winkler
Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520 8103, USA
Nature 419:952-6. 2002..We report here that mRNAs encoding enzymes involved in thiamine (vitamin B(1)) biosynthesis in Escherichia coli can bind thiamine or its pyrophosphate derivative without the ..
- Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamilyAbhishek Chatterjee
Department of Chemistry and Chemical Biology, 120 Baker Laboratory, Cornell University, Ithaca, New York 14853 1301, USA
Nat Chem Biol 4:758-65. 2008..a complex rearrangement of 5-aminoimidazole ribonucleotide (AIR) to form HMP-P, the pyrimidine moiety of thiamine phosphate...
- Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitroUrsula Schmid
Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
Diabetes Metab Res Rev 24:371-7. 2008..Owing to a reduced activity of the enzyme transketolase, which requires diphosphorylated thiamine (vitamin B(1)) as cofactor, an accumulation of those deleterious glucose metabolites especially in diabetic ..
- Dietary and socio-economic factors associated with beriberi in breastfed Lao infantsDouangdao Soukaloun
Department of Pediatrics, Mahosot Hospital, Vientiane, Lao PDR
Ann Trop Paediatr 23:181-6. 2003..signs of sepsis, hypovolaemia or cardiac abnormalities, with rapid clinical improvement following parenteral thiamine. Subjects were matched by age and diet to 43 breast-feeding healthy control infants...
- Thiamine pyrophosphate: an essential cofactor for the alpha-oxidation in mammals--implications for thiamine deficiencies?M Sniekers
Departement Moleculaire Celbiologie, Afdeling Farmacologie, Faculteit Geneeskunde, Katholieke Universiteit Leuven, O and N1, Herestraat 49, Box 601, 3000, Leuven, Belgium
Cell Mol Life Sci 63:1553-63. 2006The identification of 2-hydroxyphytanoyl-CoA lyase (2-HPCL), a thiamine pyrophosphate (TPP)-dependent peroxisomal enzyme involved in the alpha-oxidation of phytanic acid and of 2-hydroxy straight chain fatty acids, pointed towards a role ..
- Thiamine-responsive megaloblastic anemia syndrome: a disorder of high-affinity thiamine transportE J Neufeld
Division of Hematology, Children s Hospital, Boston, Massachusetts 02115, USA
Blood Cells Mol Dis 27:135-8. 2001b>Thiamine-responsive megaloblastic anemia (TRMA) syndrome (OMIM No. 249270) comprises a distinctive triad of clinical features: megaloblastic anemia with ringed sideroblasts, diabetes mellitus, and progressive sensorineural deafness...
- Effects of high glucose and thiamine on the balance between matrix metalloproteinases and their tissue inhibitors in vascular cellsSonia Tarallo
Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy
Acta Diabetol 47:105-11. 2010..We reported on reduced pericyte adhesion to high glucose-conditioned ECM and correction by thiamine. We aimed at verifying the effects of thiamine and benfotiamine on MMP-2, MMP-9 and TIMP expression and activity ..
- The relationship between plasma and red cell concentrations of vitamins thiamine diphosphate, flavin adenine dinucleotide and pyridoxal 5-phosphate following elective knee arthroplastyAndrew Gray
Department of Orthopaedics, Royal Infirmary, Glasgow G31 2ER, UK
Clin Nutr 23:1080-3. 2004..The aim of the study was to examine the relationship between plasma and intra-cellular B-vitamins following the systemic inflammatory response of surgery...
- The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporterJ C Fleming
Division of Hematology, Children s Hospital, Dana Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 22:305-8. 1999b>Thiamine-responsive megaloblastic anaemia with diabetes and deafness (TRMA; MIM 249270) is an autosomal recessive disease thought to be due to a defect in thiamine (vitamin B1) transport...
- Increasing consumption of breakfast cereal improves thiamine status in overweight/obese women following a hypocaloric dietRosa M Ortega
Departamento de Nutricion, Facultad de Farmacia, Universidad Complutense, Madrid, Spain
Int J Food Sci Nutr 60:69-79. 2009The aim of this study was to analyse the thiamine status in a group of young, overweight/obese women and to analyse the changes in this status produced by two weight-control programmes based on approximating the diet to the theoretical ..
- Disulfide-mediated apoptosis of human T-lymphotrophc virus type-I (HTLV-I)-infected cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesisYoshihiro Nishiura
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Antivir Ther 14:533-42. 2009..spastic paraparesis (HAM/TSP) using a compound that contained a disulfide moiety, prosultiamine, which is a homologue of allithiamine originally synthesized by allicin and thiamine-thiol, for the targeting of HTLV-I-infected cells.
- Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptorsL Bettendorff
Laboratory of Neurochemistry, University of Liege, Belgium
J Neurochem 64:2013-21. 1995When neuroblastoma cells were transferred to a medium of low (6 nM) thiamine concentration, a 16-fold decrease in total intracellular thiamine content occurred within 8 days...
- Biotin-responsive basal ganglia disease should be renamed biotin-thiamine-responsive basal ganglia disease: a retrospective review of the clinical, radiological and molecular findings of 18 new casesMajid Alfadhel
Division of Genetics, Department of Pediatrics, King Abdulaziz Medical City, Riyadh, Saudi Arabia
Orphanet J Rare Dis 8:83. 2013..It is characterized by sub acute encephalopathy with confusion, seizure, dysarthria and dystonia following a history of febrile illness. If left untreated with biotin, the disease can progress to severe quadriparesis and even death...
- Metabolic flux in both the purine mononucleotide and histidine biosynthetic pathways can influence synthesis of the hydroxymethyl pyrimidine moiety of thiamine in Salmonella entericaShara Allen
Department of Bacteriology, University of Wisconsin Madison, Madison 53706, USA
J Bacteriol 184:6130-7. 2002Together, the biosyntheses of histidine, purines, and thiamine pyrophosphate (TPP) contain examples of convergent, divergent, and regulatory pathway integration...
- Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular diseaseG L J Page
Academic Department of Diabetes and Endocrinology, Queen Alexandra Hospital, Portsmouth, UK
Int J Clin Pract 65:684-90. 2011..b>Thiamine is an essential cofactor in carbohydrate metabolism and individuals with diabetes are thiamine deficient...
- Modulation of cellular redox status by thiamine-activated NADPH oxidase confers Arabidopsis resistance to Sclerotinia sclerotiorumJun Zhou
MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, PR China
J Exp Bot 64:3261-72. 2013..Here, it was shown that the cellular redox status can be modulated by thiamine to protect Arabidopsis thaliana against Sclerotinia at the early stages of infection...
- Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse modelsVeedamali S Subramanian
Department of Medicine, University of California, Irvine, USA
Am J Physiol Gastrointest Liver Physiol 302:G572-8. 2012..These findings demonstrate, for the first time, that both mTHTR-1 and mTHTR-2 are involved in carrier-mediated thiamin uptake by pancreatic acinar cells...
- A wide spectrum of clinical and brain MRI findings in patients with SLC19A3 mutationsKenichiro Yamada
Department of Genetics, Institute for Developmental Research, Aichi Human Service Center, Aichi, Japan
BMC Med Genet 11:171. 2010..Homozygous or compound heterozygous mutations in SLC19A3 cause two distinct clinical phenotypes, biotin-responsive basal ganglia disease and Wernicke's-like encephalopathy. Biotin and/or thiamin are effective therapies for both diseases...
- Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitorsAllen A Thomas
Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
Bioorg Med Chem Lett 18:2206-10. 2008..In a pharmacodynamic study, nude mice with xenografted HCT-116 tumors were dosed with 1 ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an ..
- Diabetic acido-ketosis revealing thiamine-responsive megaloblastic anemiaO Bouyahia
Service de Medecine infantile A, Hopital d Enfants de Tunis, Jebari, 1007 Bab Saadoun, Tunisia
Ann Endocrinol (Paris) 70:477-9. 2009b>Thiamine-responsive megaloblastic anemia (TRMA) is a rare autosomal recessive disorder characterized by megaloblastic anemia, diabetes mellitus and progressive sensorineural deafness...
- Effect of high dose thiamine on the levels of urinary protein biomarkers in diabetes mellitus type 2Samreen Riaz
School of Biological Sciences, University of the Punjab, Lahore, Pakistan
J Pharm Biomed Anal 54:817-25. 2011..Effect of high dose thiamine has also been observed on the levels of these marker proteins...
- Non-charged thiamine analogs as inhibitors of enzyme transketolaseAllen A Thomas
Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
Bioorg Med Chem Lett 18:509-12. 2008Inhibition of the thiamine-utilizing enzyme transketolase (TK) has been linked with diminished tumor cell proliferation...
- Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetesChing Yuen Wong
Cardiology Division, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Mol Nutr Food Res 52:1421-7. 2008..intake, other dietary vitamin intake, use of antihypertensives, and lipid lowering agents, a higher intake of thiamine was significantly associated with a higher level of circulating CD34(+)/KDR(+) EPC (beta = 0.49, p = 0...
- Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetesManuel González-Ortiz
Cardiovascular Research Unit, Physiology Department, Health Science University Center, University of Guadalajara, Guadalajara, Colonia Independencia, Mexico
Eur J Nutr 50:145-9. 2011To evaluate the effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes mellitus (T2DM).
- Pyruvate dehydrogenase complex deficiency: four neurological phenotypes with differing pathogenesisChristine Barnerias
Neuropaediatric Unit, Necker Hospital, AP HP, Paris, France
Dev Med Child Neurol 52:e1-9. 2010..To describe the phenotype and genotype of pyruvate dehydrogenase complex (PDHc) deficiency...
- Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic ratsH Stracke
Center of Internal Medicine, Department of Endocrinology and Metabolism, University of Giessen, Rodthohl 6, D 35385 Giessen, Germany
Exp Clin Endocrinol Diabetes 109:330-6. 2001In rats with streptozotocin (STZ) induced diabetes the effect of (watersoluble) thiamine nitrate and of (lipidsoluble) benfotiamine on peripheral nerve function (motor nerve conduction velocity) as well as on the formation of advanced ..
- Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemiaSubodh Arora
Department of Surgery, George Washington University Medical Center, Washington, DC, USA
Ann Vasc Surg 20:653-8. 2006..b>Thiamine is a coenzyme important in intracellular glucose metabolism...
- Benfotiamine relieves inflammatory and neuropathic pain in ratsGabriela M Sánchez-Ramírez
Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados Coapa, Calzada de los Tenorios 235, Colonia Granjas Coapa, DF, Mexico
Eur J Pharmacol 530:48-53. 2006..Results indicate that oral administration of benfotiamine is able to reduce tactile allodynia from different origin in the rat and they suggest the use of this drug to reduce inflammatory and neuropathic pain in humans...
- apbA, a new genetic locus involved in thiamine biosynthesis in Salmonella typhimuriumD M Downs
Department of Bacteriology, University of Wisconsin, Madison 53706
J Bacteriol 176:4858-64. 1994In Salmonella typhimurium, the synthesis of the pyrimidine moiety of thiamine can occur by utilization of the first five steps in de novo purine biosynthesis or independently of the pur genes through the alternative pyrimidine ..
- Thiamine induced resistance to Plasmopara viticola in grapevine and elicited host-defense responses, including HR like-cell deathHatem Boubakri
Laboratoire de Physiologie Moléculaire des Plantes, Centre de Biotechnologie de Borj Cedria, 2050 Hammam Lif, Tunisia
Plant Physiol Biochem 57:120-33. 2012Recently, thiamine (VitaminB1) has been shown to induce resistance against Pseudomonas syringae in Arabidopsis plants through priming of defense responses...
- The upregulation of thiamine (vitamin B1) biosynthesis in Arabidopsis thaliana seedlings under salt and osmotic stress conditions is mediated by abscisic acid at the early stages of this stress responseMaria Rapala-Kozik
Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
BMC Plant Biol 12:2. 2012Recent reports suggest that vitamin B1 (thiamine) participates in the processes underlying plant adaptations to certain types of abiotic and biotic stress, mainly oxidative stress...
- Kinetics of thiamin and thiamin phosphate esters in human blood, plasma and urine after 50 mg intravenously or orallyC M Tallaksen
Medical Department, Aker University Hospital, Norway
Eur J Clin Pharmacol 44:73-8. 1993..The relative bioavailability of thiamin was 5.3%. A moderate amount of the administered thiamin was stored in blood. Other body tissues must play an important part, therefore, in the distribution of thiamin...
- Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathyLukáš Pácal
Department of Pathophysiology, Masaryk University, Brno, Czech Republic
Nephrol Dial Transplant 26:1229-36. 2011..We hypothesized that thiamine status (plasma and erythrocyte levels of thiamine and its esters) together with genetic variability in key PPP ..
- Transport of high concentration of thiamin, riboflavin and pyridoxine across intestinal epithelial cells Caco-2Magdalena Zielińska-Dawidziak
Department of Biotechnology and Food Microbiology, University of Life Sciences in Poznan
J Nutr Sci Vitaminol (Tokyo) 54:423-9. 2008..At high vitamin concentration the transepithelial flux of vitamins in both directions was similar, which proves the mechanism of passive transport...
- Thiamine suppresses thermal hyperalgesia, inhibits hyperexcitability, and lessens alterations of sodium currents in injured, dorsal root ganglion neurons in ratsXue Song Song
Department of Neurobiology, Parker University Research Institute, Dallas, Texas 75229, USA
Anesthesiology 110:387-400. 2009..that may support the clinical utility of B vitamins in chronic pain treatment, this study investigated effects of thiamine (B1) on the excitability and Na currents of dorsal root ganglion (DRG) neurons that have been altered by nerve ..
- Biotin-responsive basal ganglia disease-linked mutations inhibit thiamine transport via hTHTR2: biotin is not a substrate for hTHTR2Veedamali S Subramanian
Dept of Medicine, University of California, Irvine, USA
Am J Physiol Cell Physiol 291:C851-9. 2006The water-soluble micronutrient thiamine is required for normal tissue growth and development in humans...
- Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivativesMarie Laure Volvert
Center for Cellular and Molecular Neurobiology, University of Liege, Avenue de l Hopital, 1, 4000 Liege, Belgium
BMC Pharmacol 8:10. 2008Lipid-soluble thiamine precursors have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes...
- Thiamine prevents obesity and obesity-associated metabolic disorders in OLETF ratsTakao Tanaka
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
J Nutr Sci Vitaminol (Tokyo) 56:335-46. 2010We previously found that thiamine mitigates metabolic disorders in spontaneously hypertensive rats, harboring defects in glucose and fatty acid metabolism...
- Determination of the genetic, molecular, and biochemical basis of the Arabidopsis thaliana thiamin auxotroph th1Imad Ajjawi
Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV 89557, USA
Arch Biochem Biophys 459:107-14. 2007..Studies were also performed to identify the chloroplast as the specific subcellular locale of the Arabidopsis HMPPK/TMPPase...
- Signs of preclinical Wernicke's encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's syndromeAnne Lise Pitel
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
Neuropsychopharmacology 36:580-8. 2011..Whole blood thiamine was also measured in 22 of the comparison group and 28 alcoholics...
- Thiamin pyrophosphokinase is required for thiamin cofactor activation in ArabidopsisImad Ajjawi
Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV 89557, USA
Plant Mol Biol 65:151-62. 2007..These results suggest that TPK activity provides the sole mechanism by which exogenous and de novo derived thiamin is converted to the enzyme cofactor TPP...
- The multifaceted therapeutic potential of benfotiaminePitchai Balakumar
Department of Pharmacology, SB College of Pharmacy, Sivakasi 626130, India
Pharmacol Res 61:482-8. 2010b>Thiamine, known as vitamin B(1), plays an essential role in energy metabolism. Benfotiamine (S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine...
- Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in ratsD Nandi
Environmental Medicine Laboratory, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, India
Toxicology 211:26-35. 2005..ameliorative potential of certain amino acids like cysteine, methionine and vitamins like ascorbic acid and thiamine on some of the parameters indicative of oxidative stress in liver, kidney and blood and of hepatic and renal ..
- Molecular characterization of a thiJ-like gene in Chinese cabbageKyung Jin Oh
Division of Life Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 360 763, Korea
J Biochem Mol Biol 37:343-50. 2004..Examination of the tissue-specific expression revealed that the induction of the cabbage gene expression by BTH occurs in the leaf, stem, and floral tissues but not in the root...
- The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeastsEwa Kowalska
Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30 387, Krakow, Poland
Cell Mol Biol Lett 13:271-82. 2008....
- Thiamine deficiency in critically ill patients with sepsisMichael W Donnino
Department of Emergency Medicine and Internal Medicine, Division of Pulmonary Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Crit Care 25:576-81. 2010The objective of the study was to determine the prevalence of absolute thiamine deficiency (TD) in critically ill patients with sepsis and to examine the association between thiamine levels and lactic acidosis.
- Thiamine reverses hyperglycemia-induced dysfunction in cultured endothelial cellsE Ascher
Division of Vascular Surgery, Maimonides Medical Center, Brooklyn, NY 11219, USA
Surgery 130:851-8. 2001..This study investigates whether thiamine, an important coenzyme in intracellular glucose metabolism, improves endothelial cell migration and decreases von ..
- Thiamine-responsive megaloblastic anemia: identification of novel compound heterozygotes and mutation updateAnke K Bergmann
Division of Hematology and Oncology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Pediatr 155:888-892.e1. 2009To determine causative mutations and clinical status of 7 previously unreported kindreds with TRMA syndrome, (thiamine-responsive megaloblastic anemia, online Mendelian inheritance in man, no...
- A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathyAlaa Alkhalaf
Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
Diabetes Care 33:1598-601. 2010..To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy...
- High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic ratsNikolaos Karachalias
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Ann N Y Acad Sci 1043:777-83. 2005..STZ) diabetic rat experimental model of diabetes on insulin maintenance therapy exhibits dyslipidemia, mild thiamine deficiency, and increased plasma protein advanced glycation end products (AGEs)...
- Down-regulation of thiamine transporter THTR2 gene expression in breast cancer and its association with resistance to apoptosisShuqian Liu
Department of Pediatrics, University of Kentucky, Lexington, KY 40536, USA
Mol Cancer Res 1:665-73. 2003The recent molecular identification of two thiamine transporters, SLC19A2 (THTR1) and SLC19A3 (THTR2), has provided the opportunity to study thiamine transporter gene expression in human malignancies...
- Thiamine withdrawal can lead to diabetic ketoacidosis in thiamine responsive megaloblastic anemia: report of two siblingsSelim Kurtoglu
Division of Paediatric Endocrinology and Metabolism, Department of Paediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey
J Pediatr Endocrinol Metab 21:393-7. 2008b>Thiamine responsive megaloblastic anemia syndrome (TRMA), an autosomal recessive disorder caused by the deficiency of thiamine transporter protein, is the association of diabetes mellitus, anemia and deafness...
- Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53P K Lo
Institute of Biochemistry, National Yang Ming University, Shih Pai, Taipei 112, Taiwan
J Biol Chem 276:37186-93. 2001..Sequence analysis of the full-length cDNA revealed its identity as the mouse homologue of the human thiamine transporter 1 (THTR-1). Induction of the mouse THTR-1 (mTHTR-1) mRNA was detectable as early as 1 h at 32...
- Brain uptake of thiamine-coated nanoparticlesPaul R Lockman
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University HSC, Amarillo, TX 79106 1712, USA
J Control Release 93:271-82. 2003..To further these studies and to specifically target brain, we have incorporated thiamine as a surface ligand on the nanoparticles...
- Thiamine-responsive megaloblastic anemia syndrome: long term follow-upCaterina Borgna-Pignatti
Department of Clinical and Experimental Medicine Pediatrics, University of Ferrara, Ferrara, Italy
J Pediatr 155:295-7. 2009b>Thiamine-responsive megaloblastic anemia is a rare autosomal recessive disorder whose main symptoms are anemia, diabetes mellitus, and sensorineural deafness...
- SLC19: the folate/thiamine transporter familyVadivel Ganapathy
Department of Biochemistry and Molecular Biology, Medical College of Georgia, GA 30912 2100, Augusta, USA
Pflugers Arch 447:641-6. 2004..family are expressed ubiquitously and mediate the transport of two important water-soluble vitamins, folate and thiamine. The concentrative transport of substrates mediated by the members of this gene family is energized by ..
- Outbreak of beriberi in the state of Maranhão, Brazil: revisiting the mycotoxin aetiologic hypothesisHelena Cristina Alves Vieira Lima
Brazilian Field Epidemiology Training Program, Secretariat of Health Surveillance, Ministry of Health, Brasilia
Trop Doct 40:95-7. 2010Beriberi is caused by thiamine deficiency. Early 20th century epidemics in Japan were attributed to rice contaminated by citreoviridin mycotoxin...
- Prodrug thiamine analogs as inhibitors of the enzyme transketolaseYvan Le Huerou
Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
Bioorg Med Chem Lett 18:505-8. 2008..Compound 5a ('N3'-pyridyl thiamine'; 3-(6-methyl-2-amino-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride), an ..
- Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytesElena Beltramo
Laboratory of Diabetic Retinopathy, Department of Internal Medicine, University of Turin, Torino, Italy
Diabetes Metab Res Rev 25:647-56. 2009..Since human and bovine pericytes may behave differently in conditions mimicking the diabetic milieu, we verified the behaviour of human retinal pericytes cultured on HG-conditioned ECM...
- Bioadhesive capacity and immunoadjuvant properties of thiamine-coated nanoparticlesHesham H Salman
Department of Pharmaceutical Technology, University of Navarra, 31008 Pamplona, Spain
Vaccine 25:8123-32. 2007..b>Thiamine was used as specific ligand-nanoparticle conjugate (TNP) to target specific sites within the gastrointestinal ..
- Epilepsy in children with infantile thiamine deficiencyA Fattal-Valevski
Pediatric Neurology Unit, Dana Children s Hospital, Sourasky Medical Center, 6 Weitzman St, Tel Aviv, 64239, Israel
Neurology 73:828-33. 2009To report the follow-up findings of 7 children with severe epilepsy as a result of thiamine deficiency in infancy caused by a defective soy-based formula.
- Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafnessV Labay
Department of Genetics, Tamkin Human Molecular Genetics Research Facility, Technion Israel Institute of Technology, Bruce Rappaport Faculty of Medicine, Haifa
Nat Genet 22:300-4. 1999b>Thiamine-responsive megaloblastic anaemia (TRMA), also known as Rogers syndrome, is an early onset, autosomal recessive disorder defined by the occurrence of megaloblastic anaemia, diabetes mellitus and sensorineural deafness, responding ..
- Biotin-responsive basal ganglia disease in ethnic Europeans with novel SLC19A3 mutationsRabab Debs
Federation of Nervous System Diseases, Assistance Publique Hopitaux de Paris, Hopital de la Salpetriere, Universite Pierre et Marie Curie, Paris Cedex 13, France
Arch Neurol 67:126-30. 2010..To report the first 2 European cases of biotin-responsive basal ganglia disease and novel SLC19A3 mutations...
- Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegansLiesbeth de Jong
Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada
Genetics 168:845-54. 2004b>Thiamine (vitamin B1) is required in the diet of animals, and thiamine deficiency leads to diseases such as beri-beri and the Wernicke-Korsakoff syndrome...
- Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxolG A Sprenger
Institut für Biotechnologie 1 des Forschungszentrums Jülich, Germany
Proc Natl Acad Sci U S A 94:12857-62. 1997....
- Functional characterization of the thi1 promoter region from Arabidopsis thalianaDenise Teixeira Ribeiro
Depto de Botanica, Instituto de Biociencias, Universidade de Sao Paulo, Rua do Matao, 277, 05508 900 Sao Paulo, SP, Brazil
J Exp Bot 56:1797-804. 2005The Arabidopsis thaliana THI1 protein is involved in thiamine biosynthesis and is targeted to both chloroplasts and mitochondria by N-terminal control regions...
- Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THICMaja Raschke
ETH Zurich, Institute of Plant Sciences, 8092 Zurich, Switzerland
Proc Natl Acad Sci U S A 104:19637-42. 2007..The results suggest that vitamin B1 biosynthesis in plants is in fact more similar to prokaryotic counterparts and that the THIC protein is likely to be the key regulatory protein in the pathway...
- Concomitant determination of thiamin and its phosphate esters in human blood and serum by high-performance liquid chromatographyC M Tallaksen
Department of Medicine, Aker University Hospital, Oslo, Norway
J Chromatogr 564:127-36. 1991..The eluent consists of acetonitrile and phosphate buffer, in the ratios 90:10 (v/v) for the elution of thiamine and 60:40 (v/v) for the phosphate esters. The four compounds are eluted within 15 min...
- Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cellsShuqian Liu
Department of Pediatrics, College of Medicine, University of Kentucky, Lexington, Kentucky, USA
Mol Cancer Res 2:477-87. 2004In previous studies, we have shown that RNA levels of the thiamine transporter THTR2 were down-regulated in breast cancer tumors in comparison with normal tissues and that THTR2-mediated increases in thiamine uptake activity contributed ..
- Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formationS V Taylor
Department of Chemistry, Cornell University, Baker Laboratory, Ithaca, New York 14853, USA
J Biol Chem 273:16555-60. 1998..ThiF catalyzes the adenylation by ATP of the carboxyl-terminal glycine of ThiS. This reaction is likely to be involved in the activation of ThiS for sulfur transfer from cysteine or from a cysteine-derived sulfur donor...
- Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilisEthan C Settembre
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
Biochemistry 42:2971-81. 2003..The ThiO structure, as well as the observation that N-cyclopropylglycine is a good substrate, supports a hydride transfer mechanism for the enzyme. A mechanistic proposal for the role of ThiO in thiazole biosynthesis is also described...
- Thi1, a thiamine biosynthetic gene in Arabidopsis thaliana, complements bacterial defects in DNA repairC R Machado
Depto de Biologia, Universidade de Sao Paulo, Brazil
Plant Mol Biol 31:585-93. 1996..to a stress related gene from two species of Fusarium (sti35) and to genes whose products participate in the thiamine biosynthesis pathway, THI4, from Saccharomyces cerevisiae and nmt2 from Schizosaccharomyces pombe...
- Prevention of incipient diabetic cardiomyopathy by high-dose thiamineYuka Kohda
Laboratory of Pharmacotherapy, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
J Toxicol Sci 33:459-72. 2008..The hexosamine biosynthesis pathway has been implicated in signaling for fibrosis by the kidney. Thiamine (vitamin B(1)) is an indispensable coenzyme and required at intracellular glucose metabolism...
- The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis studyB Comin-Anduix
Department of Biochemistry and Molecular Biology, IDIBAPS, University of Barcelona, Spain
Eur J Biochem 268:4177-82. 2001b>Thiamine deficiency frequently occurs in patients with advanced cancer and therefore thiamine supplementation is used as nutritional support...
- Thiamine-responsive megaloblastic anemia: early diagnosis may be effective in preventing deafnessHasan Onal
Department of Pediatrics, Bakirköy Training Hospital, Istanbul, Turkey
Turk J Pediatr 51:301-4. 2009b>Thiamine-responsive megaloblastic anemia syndrome is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural hearing loss...
- Both thiamine uptake and biosynthesis of thiamine precursors are required for intracellular replication of Listeria monocytogenesKristina Schauer
Zentralinstitut für Ernährungs und Lebensmittelforschung, Abteilung Mikrobiologie, Technische Universitat Munchen, Weihenstephaner Berg, Freising, Germany
J Bacteriol 191:2218-27. 2009b>Thiamine pyrophosphate is an essential cofactor involved in central metabolism and amino acid biosynthesis and is derived from thiamine (vitamin B(1))...
- The mechanism of action of bacimethrin, a naturally occurring thiamin antimetaboliteJ J Reddick
Department of Chemistry and Chemical Biology, Cornell University, Baker Laboratory, Ithaca, NY 14853, USA
Bioorg Med Chem Lett 11:2245-8. 2001..Bacimethrin does not cause repression of the genes coding for the thiamin biosynthetic enzymes...
- thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimuriumE Webb
Department of Bacteriology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Biol Chem 273:8946-50. 1998In Salmonella typhimurium, thiamine pyrophosphate (TPP) is a required cofactor for several enzymes in central metabolism...
- The structure and ligand binding properties of the B. subtilis YkoF gene product, a member of a novel family of thiamin/HMP-binding proteinsYancho Devedjiev
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908 0736, USA
J Mol Biol 343:395-406. 2004..Calorimetric data confirmed that YkoF binds two thiamin molecules with varying affinities and a thiamine-YkoF complex was obtained by co-crystallization. The atomic model of the complex was refined using data to 2...
- Deletion of SLC19A2, the high affinity thiamine transporter, causes selective inner hair cell loss and an auditory neuropathy phenotypeM C Liberman
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
J Assoc Res Otolaryngol 7:211-7. 2006Mutations in the gene coding for the high-affinity thiamine transporter Slc19a2 underlie the clinical syndrome known as thiamine-responsive megaloblastic anemia (TRMA) characterized by anemia, diabetes, and sensorineural hearing loss...
- Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insultShane R Pitkin
Behavioral Neuroscience Program, Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13905, USA
Behav Brain Res 148:93-105. 2004..A rodent model of Wernicke-Korsakoff Syndrome (WKS), acute pyrithiamine-induced thiamine deficiency (PTD), produces diencephalic damage and impairments of memory similar to what is seen in WKS patients...
- Trophic interactions in developing and adult inner earGabriel Corfas; Fiscal Year: 2013..we evaluate inner hair cell contributions to long-term neuronal maintenance using mice lacking the high-affinity thiamine transporter such that dietary thiamine restriction leads to widespread and selective loss of inner hair cells, ..
- Thiamine Deficiency and Acquired Auditory NeuropathyM Charles Liberman; Fiscal Year: 2013..Two recent observations from our laboratory suggest that thiamine deficiency may be a key to the genesis of selective IHC loss, and therefore to acquired AN, in both prematurity ..
- Mechanism/Regulation of Intestinal Thiamin UptakeHamid M Said; Fiscal Year: 2013..abstract_text> ..
- Role of Astrocyte Injury in NeuroprotectionMartin A Philbert; Fiscal Year: 2012..diseases including Alzheimer's and Parkinson's disease and in energy deprivation syndromes such as thiamine deficiency and antimetabolite poisoning...
- Thiamine as a Metabolic Resuscitator in Septic ShockMichael William Donnino; Fiscal Year: 2012..Vitamin B1 (thiamine) is a co-factor for pyruvate dehydrogenase, an essential enzyme for aerobic metabolism...
- REGULATION OF METHIONINE METABOLISM IN BACILLUS SUBTILISTina M Henkin; Fiscal Year: 2013..riboswitch RNAs, the S box and the SMK box, with additional efforts on the lysine-binding L box, the thiamine pyrophosphate-binding Thi box, and RNA thermosensors that respond to changes in temperature...
- Memory, Thiamine Levels, and Brain Structure in Heart FailureMARY ANN WOO; Fiscal Year: 2010..in HF, with neural damage and symptoms (short-term memory loss, depression) similar to those seen in persons with thiamine deficiency...
- Mechanisms of Pancreatic Thiamin Uptake:Effect of AlcoholHamid M Said; Fiscal Year: 2013....
- Pyruvate Dehydrogenase E1: Structure-Function StudiesWilliam F Furey; Fiscal Year: 2012..The overall objective of this research is to extend our knowledge of structure-function relationships in thiamine diphosphate dependent a-keto acid decarboxylases, a large and ubiquitous class of enzymes of critical importance ..
- Effect of Thiamine on Pyruvate Dehydrogenase Activity in Septic ShockMichael William Donnino; Fiscal Year: 2013..Vitamin B1 (thiamine) is a co-factor for pyruvate dehydrogenase, an essential enzyme for aerobic metabolism...
- Structural Studies of Enzymes of Thiamin BiosynthesisSteven E Ealick; Fiscal Year: 2013..The research has implications for the commercial production of thiamin using fermentation, and for the development of antimicrobial agents that target thiamin biosynthesis. ..
- NAD Biosynthesis and the Regulation of SirtuinsJEFFREY SCOTT SMITH; Fiscal Year: 2012..We have also recently identified thiamine biosynthesis as a metabolic pathway controlled by the Sir2 and Hst1 Sirtuins in response to changes in NAD and ..
- Adaptive Regulation of Vitamin B1 TransportJason A Zastre; Fiscal Year: 2013DESCRIPTION (provided by applicant): Vitamin B1 (thiamine) is a critical enzyme cofactor within the glycolytic metabolism network that is fundamentally required to sustain the bioenergetic and anabolic needs of all cells...
- Hyperpolarized 13C Markers of Diabetic Nephropathy and Treatment ResponseZhen Jane Wang; Fiscal Year: 2013..factor erythroid 2-related factor 2 (Nrf2) pathway activator (Sulforaphane), and a transketolase activator (Thiamine) using the HP probes, with particular attention to the agents'targeted effects on oxidative stress and ..
- The mechanistic enzymology of thiamin biosynthesisTadhg P Begley; Fiscal Year: 2013..18F-thiamin has potential use, as an imaging agent, in basic human biology and in tumor rifitfictinn. . '...
- Patient-Oriented Research in Pediatric HematologyEllis J Neufeld; Fiscal Year: 2010..The first aim/project is to further characterize the rare human disorder, thiamine-responsive megaloblastic anemia, due to defects in the gene for high-affinity thiamine transporter, SLC19A2...
- Bioactivity and Vitamins in Flash-heated BreastmilkCaroline Chantry; Fiscal Year: 2005..aliquots of heated and unheated milk we will measure and compare: a) concentrations of vitamins A, ascorbic acid, thiamine, riboflavin, pyridoxine, folate and B12, known to be relatively heat-sensitive; b) concentration and ..
- HISTAMINE, IL-1 & NITRIC OXIDE IN WERNICKE LESIONSPHILIP LANGLAIS; Fiscal Year: 2002b>Thiamine deficiency-induced pathologic damage in humans is associated with Wernicke's encephalopathy (WE), Korsakoffs syndrome, and mixed sensory motor neuropathy. The prevalence of WE ranges from 1.7-2...
- SPECTROSCOPIC STUDIES OF ENZYME/SUBSTRATE COMPLEXESGeorge Reed; Fiscal Year: 2007..b>Thiamine-pyrophosphate (TPP), the cofactor form of thiamine, is essential in carbohydrate metabolism...
- Biology of lipoamide dehydrogenase and 2-hydroxy-3-oxoadipate synthase in MtbCarl F Nathan; Fiscal Year: 2013..Tet-regulated allele have developed a novel strategy to synthesize HOAS inhibitors from an analog of the cofactor thiamine diphosphate...
- Carbene-Catalyzed Reactions with Vinyl SulfonesROXANNE L ATIENZA; Fiscal Year: 2012..origin and inspiration of an NHC as a catalyst is in the human body's biological systems, where Nature uses thiamine, an NHC, to generate acetyl CoA, an important building block for polyketides...
- VITAMIN DELIVERY BY PLACENTARichard Rose; Fiscal Year: 1990..Efforts will be directed at understanding the transfer of nicotinic acid, Riboflavin, pantothenic acid, thiamine, ascorbic acid and the product of ascorbic acid oxidation, dehydroascorbic acid...
- BIOSYNTHESIS OF VITAMIN B1 AND VITAMIN B6IAN SPENSER; Fiscal Year: 2000..It is the long term objective of the study to identify the step in each pathway which is blocked in human tissues, thereby making the compounds Vitamins. ..
- Carbohydrate Metabolic PathwaysFaramarz Ismail Beigi; Fiscal Year: 2007..4) To test whether thiamine's prevention of experimental diabetic complications is by shunting glycolytic intermediates from pathways of ..
- GENETIC MECHANISMS OF ALCOHOLIC ORGANIC BRAIN DISEASEPeter Martin; Fiscal Year: 1992..Although the relative contributions of ethanol neurotoxicity and thiamine deficiency (a frequent complication of alcoholism) in the pathogenesis of alcoholic organic brain disorders ..
- MOLECULAR BASIS AND ENZYMOLOGY OF MICROBIAL BIOSYNTHESISF Tabita; Fiscal Year: 2003..For example, TK is required fro thiamine metabolism in all cells and alteration of its functional properties leads to severe pathologies including ..
- NEUROBIOLOGICAL MECHANISMS OF DIENCEPHALIC AMNESIARobert Mair; Fiscal Year: 2002..The previous 10-years of this project have shown that in a rodent model of thiamine-deficiency amnesia (similar to Korsakoff's), the critical lesions occurred in the intralaminar nuclei (ILn) of ..
- Epigenetic Contributiuns to Delirium in Mechanically Ventilated ICU PatientsMARY ELIZABETH LOUGH; Fiscal Year: 2010DESCRIPTION (provided by applicant): PURPOSE: This study will examine the association between delirium and thiamine levels, plus environmental and genetic pre-disposition to thiamine deficiency in intensive care unit (ICU) patients who ..
- MECHANISMS OF ENZYMIC AND NONENZYMIC THIAMIN REACTIONSMichael Washabaugh; Fiscal Year: 1993..Using isotopic probes, it will be determined whether the C alpha-carbanion has a significant lifetime on PDC...
- BIOMETALS, OXIDATIVE STRESS, AND AB AMYLOIDOSISXudong Huang; Fiscal Year: 2005..impact of dietary metal supplementation with Fe, Cu and Zn, as well as oxidative stress induced by the dietary thiamine deficiency, upon Abeta amyloid pathology and non-amyloid pathology using APP2576 mice; (ii) to evaluate effects ..
- Pathophysiology of thiamine-responsive anemia syndromeEllis Neufeld; Fiscal Year: 2006The goal of this proposal is to determine the pathophysiology of the autosomal recessive disorder. Thiamine-Responsive Megaloblastic Anemia (TRMA)...
- BRAIN MR SPECTROSCOPIC STUDIES OF THIAMINE DEFICIENCYHaakil Lee; Fiscal Year: 2000b>Thiamine deficiency (TD), a frequent complication of alcoholism or other disorders that interfere with normal ingestion of food, may result in brain damage...
- MOLEC GENETIC & BIOCHEM INVESTIGATION OF THIAMINE TRANSCHARLES SINGLETON; Fiscal Year: 2000DESCRIPTION: Thiamine deficiency [TD], a frequent complication of alcoholism, contributes significantly to the development of damage in various organ systems, including the brain, of alcoholics and malnourished individuals...
- BIOSYNTHESIS AND INTERCONVERSION OF PURINESJOSEPH GOTS; Fiscal Year: 1980..alterations of the reactions, to determine the interplay of purine biosynthesis with that of vitamins such as thiamine and folate cofactors...
- PHYSIOLOGICAL FUNCTIONS AND METABOLISM OF THIAMINECLARK GUBLER; Fiscal Year: 1980It is proposed to study the biochemical and functional changes in various tissues of rats made thiamine-deficient by thiamine deprivation and treatment by thiamine antagonists and by various types of stress...
- Mouse Models of Vitamin Transport DefectsJudith Fleming; Fiscal Year: 2004..member of the vitamin transporter family that includes the reduced folate carrier, SLC 19A1 and the high-affinity thiamine transporter, SLC19A2...
- THIAMINE DEFICIENCY, MEMORY, AND BRAIN GLUCOSE UPTAKEFrank Sharp; Fiscal Year: 1980..b>Thiamine is known to be an important coenzyme in normal brain glucose oxidation...
- NEUROTROPHINS AND AN ANIMAL MODEL OF FIBROMYALGIAALICE LARSON; Fiscal Year: 2003..substance P (SP) and are regulated by nerve growth factor (NGF), while others are characterized by the enzyme thiamine monophosphatase (TMPase) and are supported by glial derived neurotrophic factor (GDNF)...
- Molecular Characterization of the SLC19A2 PromoterJACK REIDLING; Fiscal Year: 2005Dietary thiamine is an essential nutrient for humans. The uptake of thiamine in the intestine has been well studied but the molecular mechanism and regulation of the uptake process is not well understood...
- Measuring Metabolites using Riboswitch reportsRonald Breaker; Fiscal Year: 2006..are widely distributed in bacteria and respond to such central molecules as glucosamine-6-phosphate (glcN6P) and thiamine pyrophosphate (TPP)...
- ETHANOL EFFECTS ON VITAMIN TRANSPORT/MITOGENIC SIGNALINGGeorge Henderson; Fiscal Year: 1993..Specific aims are 1) to establish the mechanisms of thiamine (B1) and vitamin B6 transport by the term human placenta, 2) to determine the effect of ethanol on these and 30 ..
- PATHOGENESIS & TREATMENT OF ALCOHOL-INDUCED DISEASESCharles Lieber; Fiscal Year: 1980..Interaction of alcohol and liver disease with thiamine metabolism will be evaluated including the possible consequences on the central nervous system...
- HYDROXAMIC ACID PRODUCTION IN MICROBIAL ECOSYSTEMSMichael Corbett; Fiscal Year: 1980..nitroso compounds are partially converted into aromatic hydroxamic acids by means of the action of certain thiamine dependent enzymes...
- BIOCHEMICAL LENS DAMAGE AND CATARACT RISK FACTORSGiovanni Maraini; Fiscal Year: 1990..Factors under investigation include epithelial enzymes, evaluation of thiamine and riboflavin status, sugar alcohols, water and ion content...
- 500 MHZ NMR SPECTROMETER FOR STRUCTURAL BIOLOGYRobert Oswald; Fiscal Year: 2000..Other projects focus on mechanisms of enzyme catalysis and inhibition, including thiamine sarcoma virus protease mutant (Vogt, Nicholson)...
- Cell Biology of Human Thiamine TransportersVEEDAMALI SUBRAMANIAN; Fiscal Year: 2005b>Thiamine (vitamin B1) is an important nutrient that is essential for human health...
- THE ROLE OF GLYOXYLIC ACID IN DISEASERONALD BROSEMER; Fiscal Year: 1980The role of thiamine in the etiology of human diseases is being investigated...
- BIOSYNTHESIS OF VITAMIN B1 (THIAMINE)EDWARD BELLION; Fiscal Year: 1980The research project concerns the mechanism of biosynthesis of vitamin B1 (thiamine) in bacteria...
- ENZYMATIC AND NON-ENZYMATIC DESTRUCTION OF THIAMINEJOHN ZOLTEWICZ; Fiscal Year: 1980..This work with model substrates may provide information which may lead to an understanding of the mechanism of action of thiaminase I. ..
- Electrophysiologic Measurements in Diabetic NeuropathyJoseph Arezzo; Fiscal Year: 2007..an ARI and lipid soluble thiamine derivative)...
- The Role of Acetylcholine Dysfunction in Diencephalic AmnesiaLisa M Savage; Fiscal Year: 2010..Such experiments are critical to understanding the role of acetylcholine dysfunction in amnesia and thus the development of pharmacotherapeutics. ..
- Mechanism/regulation of human intestinal thiamin uptakeHAMID SAID; Fiscal Year: 2008..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
- C elegans:a model to study intestinal water-soluble vitamins transport in vivoHAMID SAID; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mitochondiral enzymes/oxidative stress in Alzheimer'sGary Gibson; Fiscal Year: 2004..These models will also provide systems to test the efficacy of approaches to limit or reverse the changes in mitochondria. ..
- AGE/NUTRITION/GENES IN MODELS OF PSYCHIATRIC DISORDERSGary Gibson; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Thiamine (vitamin B1) deficiency (TD) produces a mild, chronic impairment of oxidative metabolism that models the diminished metabolism and reduced activities of the thiamine-dependent ..
- SIGNAL TRANSDUCTION SYSTEMS IN ALZHEIMERS DISEASEGary Gibson; Fiscal Year: 2003..abstract_text> ..