Genomes and Genes
Summary: Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
Publications360 found, 100 shown here
- Artemisinin resistance in Plasmodium falciparum malariaArjen M Dondorp
Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
N Engl J Med 361:455-67. 2009..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
- Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal studyAung Pyae Phyo
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Lancet 379:1960-6. 2012..We aimed to establish whether artemisinin resistance has spread or emerged on the Thailand-Myanmar (Burma) border...
- Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate studyChanaki Amaratunga
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
Lancet Infect Dis 12:851-8. 2012..We investigated contributions of both parasite genetics and host factors to the artemisinin-resistance phenotype in Pursat, western Cambodia...
- Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trialArjen M Dondorp
Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Lancet 376:1647-57. 2010..We compared parenteral treatment with either artesunate or quinine in African children with severe malaria...
- A major genome region underlying artemisinin resistance in malariaIan H Cheeseman
Texas Biomedical Research Institute, San Antonio, TX 78245, USA
Science 336:79-82. 2012....
- Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasiteIvo Mueller
Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
Lancet Infect Dis 9:555-66. 2009..This Review critically examines what is known about P vivax, focusing on identifying the crucial gaps that create obstacles to the elimination of this parasite in human populations...
- Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and eliminationTeun Bousema
Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
Clin Microbiol Rev 24:377-410. 2011..These components are drawn together to show how control measures that aim to reduce malaria transmission, such as mass drug administration and a transmission-blocking vaccine, might better be deployed...
- Effect of the Affordable Medicines Facility--malaria (AMFm) on the availability, price, and market share of quality-assured artemisinin-based combination therapies in seven countries: a before-and-after analysis of outlet survey dataSarah Tougher
London School of Hygiene and Tropical Medicine, London, UK
Lancet 380:1916-26. 2012..We present findings on the effect of AMFm on QAACT price, availability, and market share, 6-15 months after the delivery of subsidised ACTs in Ghana, Kenya, Madagascar, Niger, Nigeria, Uganda, and Tanzania (including Zanzibar)...
- Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimatorJennifer A Flegg
WorldWide Anti malarial Resistance Network WWARN and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
Malar J 10:339. 2011..This lag complicates the clearance estimation, introduces observer subjectivity, and may influence the accuracy and consistency of reported results...
- Thousands of chemical starting points for antimalarial lead identificationFrancisco Javier Gamo
Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Spain
Nature 465:305-10. 2010..Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with ..
- Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trialArjen Dondorp
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Lancet 366:717-25. 2005..In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain...
- Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trialsJohn J Aponte
Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
Lancet 374:1533-42. 2009..Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa...
- Malaria in Brazil: an overviewJoseli Oliveira-Ferreira
Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, FIOCRUZ, Pavilhão Leônidas Deane 5 degrees andar, Av Brasil 4365, Manguinhos, Rio de Janeiro, RJ CEP 21 045 900, RJ Brazil
Malar J 9:115. 2010....
- Genetic diversity and chloroquine selective sweeps in Plasmodium falciparumJohn C Wootton
Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 6075, USA
Nature 418:320-3. 2002..The presence of linkage disequilibrium provides a basis for mapping genes under drug selection in P. falciparum...
- Production of the antimalarial drug precursor artemisinic acid in engineered yeastDae Kyun Ro
California Institute of Quantitative Biomedical Research, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
Nature 440:940-3. 2006..annua, yield optimization and industrial scale-up will be required to raise artemisinic acid production to a level high enough to reduce artemisinin combination therapies to significantly below their current prices...
- Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countriesKathryn A O'Connell
Population Services International, Malaria and Child Survival Department, P O Box 43640, Nairobi, Kenya
Malar J 10:326. 2011..This paper presents supply side data from ACTwatch outlet surveys in Benin, the Democratic Republic of Congo (DRC), Madagascar, Nigeria, Uganda and Zambia...
- Artemisinin resistance: current status and scenarios for containmentArjen M Dondorp
Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok10400, Thailand
Nat Rev Microbiol 8:272-80. 2010..Mathematical modelling can be a useful tool to evaluate possible strategies for containment...
- New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistanceRic N Price
International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia
Curr Opin Infect Dis 22:430-5. 2009..vivax infection. We review the evidence for severe disease and the spread of drug-resistant P. vivax and speculate how these maybe related...
- Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deploymentVerena Ilona Carrara
Shoklo Malaria Research Unit, Tak, Thailand
PLoS ONE 4:e4551. 2009....
- Protection against a malaria challenge by sporozoite inoculationMeta Roestenberg
Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
N Engl J Med 361:468-77. 2009..Naturally acquired immunity to malaria develops slowly, and induction of protection in humans can be achieved artificially by the inoculation of radiation-attenuated sporozoites by means of more than 1000 infective mosquito bites...
- The state of the art in anti-malarial drug discovery and developmentJeremy N Burrows
Medicines for Malaria Venture, ICC, Geneva, Switzerland
Curr Top Med Chem 11:1226-54. 2011..This review summarises the antimalarials developed and registered thus far, as well as describing some of the new small molecule therapy approaches ..
- Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey dataAnna Maria van Eijk
Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK
Lancet Infect Dis 11:190-207. 2011..We aimed to synthesise data from national surveys about these interventions, accounting for disparities in malaria risk within national borders...
- Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countriesMegan Littrell
Population Services International, Malaria and Child Survival Department, PO Box 43640, Nairobi, Kenya, Africa
Malar J 10:327. 2011..These data provide a baseline for monitoring interventions to increase ACT coverage, such as the Affordable Medicines Facility for malaria (AMFm)...
- Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in MalawiJames G Kublin
Malaria Section, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Infect Dis 187:1870-5. 2003..The reintroduction of chloroquine, ideally in combination with another antimalarial drug, should be considered in areas where chloroquine resistance has declined and safe and affordable alternatives remain unavailable...
- Community case management of malaria using ACT and RDT in two districts in Zambia: achieving high adherence to test results using community health workersPascalina Chanda
Department of Public Health and Research, Ministry of Health Headquarters, Lusaka, Zambia
Malar J 10:158. 2011..WHO recommends home management of malaria using artemisininbased combination therapy (ACT) and Rapid Diagnostic tests (RDTs) as one of the strategies for improving access to prompt and efective malaria case management...
- Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blueSophie H Adjalley
Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 108:E1214-23. 2011..Efforts to measure the activity of existing antimalarials on intraerythrocytic sexual stage gametocytes and identify transmission-blocking agents have, until now, been ..
- Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, MalaysiaTimothy William
Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysian Borneo
Emerg Infect Dis 17:1248-55. 2011..P. knowlesi is a major cause of severe and fatal malaria in Sabah. Artemisinin derivatives rapidly clear parasitemia and are efficacious in treating uncomplicated and severe knowlesi malaria...
- Improved diagnostic testing and malaria treatment practices in ZambiaDavidson H Hamer
Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
JAMA 297:2227-31. 2007....
- From malaria control to eradication: The WHO perspectiveKamini Mendis
Global Malaria Programme, World Health Organization, Geneva, Switzerland
Trop Med Int Health 14:802-9. 2009..The prospects of malaria eradication, therefore, rest heavily on the outcomes of research and development for new and improved tools. Malaria control and elimination are complementary objectives in the global fight against malaria...
- Spiroindolones, a potent compound class for the treatment of malariaMatthias Rottmann
Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH 4002 Basel, Switzerland
Science 329:1175-80. 2010Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments...
- The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasitesMichael Delves
Department of Life Sciences, Imperial College London, London, UK
PLoS Med 9:e1001169. 2012..These new medicines are needed both to meet the challenge of malaria eradication and to circumvent resistance...
- The magnitude and trend of artemether-lumefantrine stock-outs at public health facilities in KenyaRaymond K Sudoi
Malaria Public Health and Epidemiology Group, KEMRI Wellcome Trust Research Programme, PO Box 43640, 00100 GPO Nairobi, Kenya
Malar J 11:37. 2012..Here, 2010-2011 data are reported from public facilities in Kenya where alarming stock-outs were revealed in 2008...
- Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discoveryStephan Meister
Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
Science 334:1372-7. 2011..The open-source chemical tools resulting from our effort provide starting points for future drug discovery programs, as well as opportunities for researchers to investigate the biology of exo-erythrocytic forms...
- Malaria case-management following change of policy to universal parasitological diagnosis and targeted artemisinin-based combination therapy in KenyaAndrew Nyandigisi
Division of Malaria Control, Ministry of Public Health and Sanitation, Nairobi, Kenya
PLoS ONE 6:e24781. 2011..We evaluated changes in health systems and case-management indicators between the baseline survey undertaken before implementation of the policy and the follow-up survey following the first year of the implementation activities...
- Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trialKojo Yeboah-Antwi
Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
PLoS Med 7:e1000340. 2010..This study was designed to assess the effectiveness and feasibility of using CHWs to manage nonsevere pneumonia and uncomplicated malaria with the aid of rapid diagnostic tests (RDTs)...
- Clinical and laboratory features of human Plasmodium knowlesi infectionCyrus Daneshvar
Malaria Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Malaysia
Clin Infect Dis 49:852-60. 2009..Plasmodium knowlesi is increasingly recognized as a cause of human malaria in Southeast Asia but there are no detailed prospective clinical studies of naturally acquired infections...
- Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparumM B Reed
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Nature 403:906-9. 2000..However, conclusive evidence of a direct causal association between pfmdr1 and resistance to these antimalarials has remained elusive, and a single genetic cross has suggested that Pgh1 is not involved in resistance to ..
- Malaria indicator survey 2007, Ethiopia: coverage and use of major malaria prevention and control interventionsDaddi Jima
Diseases Prevention and Control Department, Federal Ministry of Health, Addis Ababa, Ethiopia
Malar J 9:58. 2010....
- Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up studyMeta Roestenberg
Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Lancet 377:1770-6. 2011..This immunity was associated with parasite-specific production of interferon γ and interleukin 2 by pluripotent effector memory cells in vitro. We aim to explore the persistence of protection and immune responses in the same volunteers...
- Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoitesMallika Imwong
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
J Infect Dis 195:927-33. 2007..Thus, reappearance of parasitemia after treatment can result from relapse, recrudescence, or reinfection. It has been assumed that parasites causing relapse would be a subset of the parasites that caused the primary infection...
- Chemical genetics of Plasmodium falciparumW Armand Guiguemde
Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nature 465:311-5. 2010..falciparum and related protozoans. One exemplar compound displayed efficacy in a murine model. Our findings provide the scientific community with new starting points for malaria drug discovery...
- Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast AsiaHarald Noedl
Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
Clin Infect Dis 51:e82-9. 2010..This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine...
- Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan AfricaLaith J Abu-Raddad
Statistical Center for HIV Aids Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Science 314:1603-6. 2006..Hence, transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa...
- Marked increase in child survival after four years of intensive malaria controlImmo Kleinschmidt
London School of Hygiene and Tropical Medicine, London, United Kingdom Medical Care Development International, Silver Spring, Maryland
Am J Trop Med Hyg 80:882-8. 2009..34 [95% CI = 0.23-0.49]). Effective malaria control measures can dramatically increase child survival and play a key role in achieving millennium development goals...
- Getting antimalarials on target: impact of national roll-out of malaria rapid diagnostic tests on health facility treatment in three regions of TanzaniaKatia Bruxvoort
London School of Hygiene and Tropical Medicine, London, UK Ifakara Health Institute, Dar es Salaam, Tanzania
Trop Med Int Health 18:1269-82. 2013..To evaluate the impact on case management practices of routine government implementation of mRDTs, we conducted large-scale health facility surveys in three regions of Tanzania before and after mRDT roll-out...
- Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western CambodiaBenoit Witkowski
Malaria Molecular Epidemiology Unit, Institut Pasteur in Cambodia, Phnom Penh, Cambodia
Antimicrob Agents Chemother 57:914-23. 2013..The reduced susceptibility to artemisinin in Pailin appears to be associated with an altered in vitro phenotype of ring stages from Pailin in the RSA...
- Chemoresistance of Plasmodium falciparum and Plasmodium vivax parasites in Brazil: consequences on disease morbidity and controlBianca Ervatti Gama
Centro de Pesquisa em Malária, Centro de Pesquisa, Diagnóstico e Treinamento em Malária, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, RJ, Brasil
Mem Inst Oswaldo Cruz 106:159-66. 2011..Additionally, in vivo, in vitro and molecular studies as well as malaria chemoresistance consequences on disease morbidity and policy treatment guidelines were commented...
- The combined effect of determinants on coverage of intermittent preventive treatment of malaria during pregnancy in the Kilombero Valley, TanzaniaKarin Gross
Swiss Tropical and Public Health Institute, Basel, Switzerland
Malar J 10:140. 2011..This paper investigates the combined impact of pregnant women's timing of ANC attendance, health workers' IPTp delivery and different delivery schedules of national IPTp guidelines on IPTp coverage...
- Global phenotypic screening for antimalarialsW Armand Guiguemde
Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
Chem Biol 19:116-29. 2012..To compound the problem, drug resistance has emerged to all classical antimalarials and may be emerging for artemisinin-based combination therapies...
- A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite developmentBenoit Malleret
Laboratory of Malaria Immunobiology, Singapore Immunology Network SIgN, Agency for Science, Technology and Research A STAR, Biopolis, Singapore
Sci Rep 1:118. 2011..It also allows assessing the proportion of parasites at different developmental stages. Lastly, we demonstrate how this technique can be applied to antimalarial drug testing...
- Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational studyRashid A Khatib
Ifakara Health Institutce, Dar es Salaam, Tanzania
Malar J 11:140. 2012....
- Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural TanzaniaOliver J Sabot
Malaria Control Team, Clinton Foundation HIV AIDS Initiative, Boston, Massachusetts, USA
PLoS ONE 4:e6857. 2009..To overcome this challenge, a global ACT subsidy has been proposed. We tested this proposal through a pilot program in rural Tanzania...
- P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-actionLaura M Sanz
Tres Cantos Medicine Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain
PLoS ONE 7:e30949. 2012..This approach has been adapted to perform medium throughput screening, facilitating the identification of fast-acting antimalarial compounds, which are crucially needed for the control and possibly the eradication of malaria...
- Intercontinental spread of pyrimethamine-resistant malariaCally Roper
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Science 305:1124. 2004..The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis...
- Reducing the burden of malaria in pregnancy by preventive strategiesClara Menendez
Center for International Health, Hospital Clinic Barcelona University, Barcelona, Spain
Lancet Infect Dis 7:126-35. 2007....
- Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trialAung Pyae Phyo
Shoklo Malaria Research Unit, Mae Sod
Clin Infect Dis 53:977-84. 2011..Chloroquine (CQ) remains the treatment of choice for Plasmodium vivax malaria. Initially confined to parts of Indonesia and Papua, resistance of P. vivax to CQ seems to be spreading, and alternative treatments are required...
- Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparumConnor O'Brien
Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Curr Opin Infect Dis 24:570-7. 2011..However, recent reports from the Thai-Cambodian border reveal evidence of emerging resistance to artemisinins. The latest published clinical and molecular findings are summarized herein...
- Drug-resistant malaria: molecular mechanisms and implications for public healthInes Petersen
Department of Infectious Diseases, Parasitology, Universitatsklinikum Heidelberg, Heidelberg, Germany
FEBS Lett 585:1551-62. 2011..This review attempts to summarize the unique factors presented by malarial parasites that lead to the emergence and spread of drug resistance, and gives an overview of known resistance mechanisms to currently used antimalarial drugs...
- Major reduction in anti-malarial drug consumption in Senegal after nation-wide introduction of malaria rapid diagnostic testsSylla Thiam
Programme National de Lutte contre le Paludisme, Ministere de la Sante, Dakar Fann, Senegal
PLoS ONE 6:e18419. 2011..This paper assesses the impact of this programme on anti-malarial drug consumption and disease reporting...
- Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999-2008Maru W Aregawi
World Health Organization, Global Malaria Programme, 20 Avenue Appia 1211 Geneva 27, Switzerland
Malar J 10:46. 2011..The impact of the scale-up of insecticide-treated nets (ITN), indoor-residual spraying (IRS) and artemisinin-combination therapy (ACT) combined on malaria burden was assessed at six out of seven in-patient health facilities...
- Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in UgandaDaniel J Kyabayinze
Malaria Consortium Africa, Plot 2, Sturrock Road, PO Box 8045, Kampala, Uganda
Malar J 9:200. 2010..This study evaluated the effect of malaria RDTs on health workers' anti-malarial drug (AMD) prescriptions among outpatients at low level health care facilities (LLHCF) within different malaria epidemiological settings in Uganda...
- Resistance to therapies for infection by Plasmodium vivaxJ Kevin Baird
Eijkman Oxford Clinical Research Unit, Jalan Diponegoro No 69, Jakarta 10430, Indonesia
Clin Microbiol Rev 22:508-34. 2009....
- The parasite clearance curveN J White
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Malar J 10:278. 2011..The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed...
- Reduction of anti-malarial consumption after rapid diagnostic tests implementation in Dar es Salaam: a before-after and cluster randomized controlled studyValérie D'Acremont
Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland
Malar J 10:107. 2011..Presumptive treatment of all febrile patients with anti-malarials leads to massive over-treatment. The aim was to assess the effect of implementing malaria rapid diagnostic tests (mRDTs) on prescription of anti-malarials in urban Tanzania...
- Chloroquine-resistant Plasmodium vivax, Brazilian AmazonFranklin Simoes de Santana Filho
Emerg Infect Dis 13:1125-6. 2007
- Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trialFrank Smithuis
Medecins Sans Frontieres Holland, Yangon, Myanmar
Lancet Infect Dis 10:673-81. 2010..We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the addition of a single gametocytocidal dose of primaquine...
- The potential contribution of mass treatment to the control of Plasmodium falciparum malariaLucy C Okell
Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modeling, Imperial College London, London, United Kingdom
PLoS ONE 6:e20179. 2011..The benefits of mass treatment need to be carefully weighed against the risks of increasing drug selection pressure...
- In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screenDavid Plouffe
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 105:9059-64. 2008..To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-throughput cell-based screen (1,536-well format) based on ..
- Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screeningMartin Smilkstein
Medical Research Service, Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon, USA
Antimicrob Agents Chemother 48:1803-6. 2004..The results obtained with this new fluorescence assay suggest that it may be an ideal method for high-throughput antimalarial drug screening...
- Adherence to a six-dose regimen of artemether-lumefantrine among uncomplicated Plasmodium falciparum patients in the Tigray Region, EthiopiaHailemariam Lemma
Tigray Health Bureau, Mekelle, Ethiopia
Malar J 10:349. 2011..The aim of this study was to measure patient adherence levels to the six-dose AL regimen for the treatment of uncomplicated P. falciparum malaria and to identify its determinant factors in rural areas of the Tigray region, Ethiopia..
- Medicine sellers and malaria treatment in sub-Saharan Africa: what do they do and how can their practice be improved?Catherine Goodman
Health Economics and Financing Programme, Health Policy Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
Am J Trop Med Hyg 77:203-18. 2007..Interventions must be adapted to include artemisinin-based combination therapies, and their sustainability and potential to operate at a national level should be further explored...
- Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trialYi Poravuth
National Malaria Center, Phnom Penh, Cambodia
PLoS ONE 6:e14501. 2011New antimalarials are needed for P. vivax and P. falciparum malaria. This study compared the efficacy and safety of pyronaridine-artesunate with that of chloroquine for the treatment of uncomplicated P. vivax malaria.
- Socially-marketed rapid diagnostic tests and ACT in the private sector: ten years of experience in CambodiaShunmay Yeung
Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, UK
Malar J 10:243. 2011..In Cambodia, this is particularly complicated due to problems inherent to the drug itself and the emergence of artemisinin resistance...
- Severe Plasmodium vivax malaria, Brazilian AmazonMárcia A Alexandre
Fundacao de Medicina Tropical do Amazonas, Manaus, Brazil
Emerg Infect Dis 16:1611-4. 2010..The major complications were jaundice and severe anemia. No in vivo chloroquine resistance was detected. These data help characterize the clinical profile of severe P. vivax malaria in Latin America...
- Options for the delivery of intermittent preventive treatment for malaria to children: a community randomised trialMargaret Kweku
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 4:e7256. 2009..We have evaluated the coverage of IPTc that can be achieved by two different delivery systems in Ghana...
- Primaquine therapy for malariaJ Kevin Baird
US Naval Medical Research Center Detachment, Lima, Peru
Clin Infect Dis 39:1336-45. 2004..5 mg/kg primaquine daily for 14 days, on the basis of superior efficacy and good tolerability and safety in nonpregnant persons without glucose-6-phosphate dehydrogenase deficiency...
- Artemisinin combination therapy for vivax malariaNicholas M Douglas
Menzies School of Health Research, Darwin, NT, Australia
Lancet Infect Dis 10:405-16. 2010..Analyses of the cost-effectiveness of ACTs for both Plasmodium species are needed to assess the role of these drugs in the control and elimination of vivax malaria...
- Severe Plasmodium vivax malaria exhibits marked inflammatory imbalanceBruno B Andrade
Centro de Pesquisas Gonçalo Moniz CPqGM, Fundação Oswaldo Cruz FIOCRUZ, Salvador, Bahia, Brazil
Malar J 9:13. 2010..In this report, the inflammatory and immunological status of both mild and severe vivax malaria cases are compared in order to explore immunopathological events in this disease...
- Chloroquine resistance before and after its withdrawal in KenyaLeah Mwai
Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
Malar J 8:106. 2009..Changes to those that occurred in the dihydrofolate reductase gene (dhfr) that confers resistance to the replacement drug, pyrimethamine/sulphadoxine were also compared...
- Rapid testing for malaria in settings where microscopy is available and peripheral clinics where only presumptive treatment is available: a randomised controlled trial in GhanaEvelyn K Ansah
Dangme West District Health Directorate, Dodowa, Ghana
BMJ 340:c930. 2010To test in West Africa the impact of rapid diagnostic tests on the prescription of antimalarials and antibiotics both where microscopy is used for the diagnosis of malaria and in clinical (peripheral) settings that rely on clinical ..
- Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trialJacek Skarbinski
Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Am J Trop Med Hyg 80:919-26. 2009..30). RDTs could potentially improve malaria case management, but we urgently need to develop more effective strategies for implementing guidelines before large scale implementation...
- Severe imported falciparum malaria: a cohort study in 400 critically ill adultsFabrice Bruneel
Service de Reanimation, Centre Hospitalier de Versailles, Le Chesnay, France
PLoS ONE 5:e13236. 2010..We sought to describe the clinical spectrum of severe imported malaria in French adults and to identify risk factors for mortality at admission to the intensive care unit...
- In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)Christin Sisowath
Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
J Infect Dis 191:1014-7. 2005..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
- Impact of malaria at the end of pregnancy on infant mortality and morbidityAzucena Bardaji
Barcelona Centre for International Health Research and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Spain
J Infect Dis 203:691-9. 2011..There is some consensus that malaria in pregnancy may negatively affect infant's mortality and malaria morbidity, but there is less evidence concerning the factors involved...
- Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic testValérie D'Acremont
Swiss Tropical and Public Health Institute, Basel, Switzerland
Clin Infect Dis 51:506-11. 2010..The objective of the present study was to evaluate the safety of withholding antimalarials in febrile children who have a negative test result.
- Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trialBoubacar Coulibaly
Centre de Recherche en Santé de Nouna, Nouna, Burkina Faso
PLoS ONE 4:e5318. 2009..We here report on the effects of methylene blue (MB)-based malaria combination therapy on gametocytaemia during a randomised-controlled trial in Burkina Faso...
- A high-throughput screen targeting malaria transmission stages opens new avenues for drug developmentKathrin Buchholz
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
J Infect Dis 203:1445-53. 2011..is widespread, and there is an urgent need for novel approaches to reduce the emergence of resistance to new antimalarials as they are introduced...
- Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistanceMaria Isabel Veiga
Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e20212. 2011..Our work unveils new candidate markers of P. falciparum multidrug resistance in vitro, while contributing to the understanding of subjacent genetic complexity, essential for future evidence-based drug policy decisions...
- Poor quality vital anti-malarials in Africa - an urgent neglected public health priorityPaul N Newton
Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Malar J 10:352. 2011..A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. However, there are increasing reports of poor quality anti-malarials in Africa...
- Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and BelgiumAnnemarie R Kreeftmeijer-Vegter
Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands
Malar J 11:102. 2012..Fortunately, artesunate became available in the Netherlands and Belgium through a named patient programme. This is the largest case series of artesunate treated patients with severe malaria in Europe...
- Malaria misdiagnosis in Uganda--implications for policy changeJoan Nankabirwa
Malaria Consortium, Africa Regional Office, Kampala, Uganda
Malar J 8:66. 2009..In this study, the policy implications of such recommendations are revisited...
- In vivo parasitological measures of artemisinin susceptibilityKasia Stepniewska
Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
J Infect Dis 201:570-9. 2010....
- How can malaria rapid diagnostic tests achieve their potential? A qualitative study of a trial at health facilities in GhanaClare I R Chandler
Clinical Research Unit, London School of Hygiene and Tropical Medicine Keppel Street, London, WC1E 7HT, UK
Malar J 9:95. 2010..A recent trial in rural health facilities in Ghana reduced overprescription of anti-malarials, but found that 45.5% patients who tested negative with RDTs were still prescribed an anti-malarial...
- Molecular analysis of pfatp6 and pfmdr1 polymorphisms and their association with in vitro sensitivity in Plasmodium falciparum isolates from the Thai-Myanmar borderPapichaya Phompradit
Thailand Center of Excellence on Drug Discovery and Development, Thammasat University, Rangsit Campus, Patumthani 12121, Thailand
Acta Trop 120:130-5. 2011..No association between mutation or amplification of pfatp6 gene and in vitro susceptibility of P. falciparum isolates was found...
- High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western CambodiaTim J C Anderson
Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, Texas 78245, USA
J Infect Dis 201:1326-30. 2010....
- Accuracy of malaria rapid diagnostic tests in community studies and their impact on treatment of malaria in an area with declining malaria burden in north-eastern TanzaniaDeus S Ishengoma
National Institute for Medical Research, Tanga Medical Research Centre, P O Box 5004, Tanga, Tanzania
Malar J 10:176. 2011....
- Spread and evolution of Plasmodium falciparum drug resistanceToshihiro Mita
Department of International Affairs and Tropical Medicine, Tokyo Women s Medical University, School of Medicine, 9 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
Parasitol Int 58:201-9. 2009Worldwide spread of Plasmodium falciparum drug resistance to conventional antimalarials, chloroquine and sulfadoxine/pyrimethamine, has been imposing a serious public health problem in many endemic regions...
- Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in MaliAlassane Dicko
Malaria Research and Training Center, Departments of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, P O Box 1805, Bamako, Mali
Malar J 7:123. 2008..However in most areas malaria morbidity and mortality remain high in older children...
- Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in MaliAlassane Dicko
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine Pharmacy and Dentistry, University of Bamako, PO Box 1805 Bamako, Mali
Malar J 9:9. 2010..However, there is a fear that IPTi may result in a rapid increase of parasite resistance to SP...
- Cost savings with rapid diagnostic tests for malaria in low-transmission areas: evidence from Dar es Salaam, TanzaniaJoshua Yukich
Department of International Health and Development, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2200 TB46, New Orleans, LA 70112 2715, USA
Am J Trop Med Hyg 83:61-8. 2010..002). The RDTs reduced drug costs in this setting but did not offset the cost of the tests, although they also resulted in non-monetary benefits, including improved management of patients and increased compliance with test results...
- Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: a randomised controlled non-inferiority trialHarry Tagbor
Department of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
PLoS ONE 5:e14425. 2010..Therefore, we have investigated whether screening with a rapid diagnostic test and treatment of those who are positive (IST) at routine antenatal clinic attendances is as effective and as safe as SP-IPTp in pregnant women...
- Latin American Center for Malaria Research and ControlSOCRATES HERRERA VALENCIA; Fiscal Year: 2013..is endemic, including adherence, self-medication and prophylaxis;and (b) study the conditions of use of antimalarials in the public and private health institutions including the availability and suitability to care guides...
- Development of Small Antimicrobial Peptide Mimics as Drug-Resistant and SusceptibRichard W Scott; Fiscal Year: 2013..We propose that antimicrobial peptides (AMPs) may provide the basis of a novel class of antimalarials. AMPs are an essential component of the innate immune system...
- Molecular epidemiology of drug resistance and population genetic structure of PlaFangli Lu; Fiscal Year: 2013..vivax transmission in Yunnan and Hainan, China. 1 ..
- Identification of G6PD inhibitors for the development of novel antimalarial drugsLars Bode; Fiscal Year: 2010..We aim at identifying compounds that inhibit this enzyme both in malaria parasites and, to a certain extent, in humans. Our results may pave the way for the development of novel antimalarial drugs. ..
- Pilot studies of the molecular epidemiology of drug-resistant malaria in MyanmarChristopher V Plowe; Fiscal Year: 2013..This work is expected to contribute to the development of robust surveillance tools that can be used to track and contain artemisinin resistance in Southeast Asia and elsewhere. ..
- Purine Pathways and Inhibitor Design in PlasmodiumVern L Schramm; Fiscal Year: 2012..The parasite has acquired resistance against most antimalarials and new drugs are required. P...
- Functional genomic analysis of host determinants of malaria infectionElizabeth Egan; Fiscal Year: 2013..The results of this work will ultimately guide the rational development of host-targeted therapeutics for malaria. ..
- Tulane-Xavier Minority Training in International HealthRichard A Oberhelman; Fiscal Year: 2013....
- Mitochondrial Functions in Malaria ParasitesAkhil B Vaidya; Fiscal Year: 2013..at the cytochrome bc1 complex by at least 3 additional chemical classes of compounds under development as antimalarials. We showed that a critical function of mtETC in Plasmodium falciparum blood stages was to serve as an electron ..
- Inhibition of Autophagy: A Novel Therapeutic Strategy for Advanced Solid TumorsFrancis J Giles; Fiscal Year: 2010....
- Designed Antimalarial Agents Overcoming Chloroquine-ResistanceDavid H Peyton; Fiscal Year: 2010..This work is to develop further promising lead candidates from a new class of drugs, `reversed chloroquines'(RCQs), designed to overcome this resistance. ..
- Malaria melatonin receptor signaling as a novel drug targetAndrew P Thomas; Fiscal Year: 2013..Techniques include live-cell fluorescence imaging, imaging flow cytometry, in vivo malaria models, and synthetic chemistry. ..
- Perturbations of host cell signaling by a complex hepatotropic pathogenStefan H I Kappe; Fiscal Year: 2013..Perturbations of hepatocyte signaling by a complex intracellular pathogen might also reveal new intrinsic features of the signaling system within hepatocytes. ..
- Development of an activity based probe family for metallo aminopeptidasesDoron Greenbaum; Fiscal Year: 2010..causes most malaria associated deaths, has now become a major problem necessitating the discovery of novel antimalarials. Peptidases participate in several critical pathways during the life cycle of P...
- Function and Inhibition of Plasmodium Lipid DecarboxylasesChoukri Ben Mamoun; Fiscal Year: 2013..falciparum development as well as fostering the design of specific inhibitors. This work will provide new therapeutic insights for combating a disease that affects 250 million people worldwide and causes 1 million deaths each year. ..
- Optimizing Novel Dihydroorotate Dehydrogenase Inhibitors for Treating MalariaDavid Waterson; Fiscal Year: 2011..Once a compound has been nominated, MMV will fund and manage the GLP preclinical development program and First in Human (FIH) Phase 1 clinical trials as part of its internally funded clinical development program. ..
- Optimization of pyrimidinyl prodrugs (PYPs) for malaria chemotherapyPRADIPSINH RATHOD; Fiscal Year: 2009..to potency, safety, cost of goods, low propensity for resistance, and lack of cross-resistance to other antimalarials, 6-carboxy-2,4-dioxo-5- fluoropyrimidine (5-fluoroorotate or PYP1) stands out as the best hit...
- Small molecule protein-glycan inhib. as malaria transmission-blocking therapueticRHOEL DAVID RAMOS DINGLASAN; Fiscal Year: 2013..This strategy is especially important given that many current antimalarials and vaccine candidates still permit transmission of the parasite through the mosquito, moreover, our lead ..
- Blood Filtration System for the Treatment of Severe Malaria PatientsAlberto Gandini; Fiscal Year: 2013..abstract_text> ..
- Optimizing Pharmachins for Treatment and Prevention of Drug Resistant MalariaMICHAEL KEVIN RISCOE; Fiscal Year: 2013..The resultant advantages of avoiding drug toxicity, febrile illness and complex medical management during deployment are also self-evident, as are the benefits to both short and long-term health of the US soldier. ..
- Defining the targets of broad intervention antimalarial agentsElizabeth A Winzeler; Fiscal Year: 2013....
- Sustainable Financial Incentives To Improve Prescription Practices For MalariaWENDY PRUDHOMME O'MEARA; Fiscal Year: 2013..tests (RDTs) are available, between 50-80% of patients with a negative test are nonetheless prescribed antimalarials. Inappropriately treated fevers in children can lead to serious consequences for the patient and can ..
- Efficacy evaluation of traditionally used antimalarial plantsROCKY T GRAZIOSE; Fiscal Year: 2012..Currently, no drugs are universally successful in treating malaria due to widespread drug resistance;new antimalarials are desperately needed...
- Ruthenium-based antimalarial agentsROBERTO A SANCHEZ-DELGADO; Fiscal Year: 2013..This proposal presents a promising alternative toward the development of novel and effective metal-based antimalarial therapies and it opens important avenues of research for understanding their mechanisms of action. ..
- Discovering new compounds to treat global infectious diseaseEmily R Derbyshire; Fiscal Year: 2013..In these areas, parasites can rapidly develop drug resistance, which erodes the efficacy of antimalarials. Thus new drugs and the identification of novel targets are desperately needed to treat malaria...
- Immunologic consequences of highly effective antimalarial chemopreventionPrasanna Jagannathan; Fiscal Year: 2013..At the completion of this award, Dr. Jagannathan will be well positioned to develop an R01 application to further define correlates and mechanisms of protective immunity to malaria. ..
- Discovery of chemically validated malaria liver stage targetsElizabeth A Winzeler; Fiscal Year: 2013..The inability to eliminate cryptic liver forms creates a barrier to malaria eradication. We propose to find new targets that are critical to the liver stages as well as the blood stages with the long term aim of designing better drugs. ..
- Novel Plasmodial Surface Anion Channel Inhibitors as Antimalarial DrugsMichelle M Butler; Fiscal Year: 2013..provided by applicant): The overall objective of this project is to generate new, potent, selective antimalarials that act through a novel mechanism of blocking the plasmodial surface anion channel (PSAC), a previously ..
- Testing feasibility of artemisinin-based synthetic-lethal suppression of skin phoGeorg T Wondrak; Fiscal Year: 2013..Critical proof-of-principle data will be generated guiding the rational design of future mechanistic and preclinical studies that validate synthetic-lethal approaches for photochemoprevention. ..
- Identifaction of the genetic basis of primaquine resistance in malaria parasitesERIKA LEA FLANNERY; Fiscal Year: 2013..Identification of these determinants will inform the development of new antimalarials that target liver-stage P. vivax...
- Identification of Novel Plant-derived Antimalarial CompoundsSusan L Mooberry; Fiscal Year: 2012..To date no malaria vaccine has been developed and parasites resistant to all classes of antimalarials exist in many areas of the world...
- High Throughput Screens for Malaria TopoisomerasesPradipsinh K Rathod; Fiscal Year: 2013..The search for new antimalarials will be greatly aided by a High Throughput Assay (HTA) for Plasmodium topoisomerases, since such enzymes are ..
- Lead optimization of DHODH inhibitors for malariaMargaret A Phillips; Fiscal Year: 2013..public private partnerships such as Medicines for Malaria Venture (MMV) to manage the development of new antimalarials. MMV has the largest drug development pipeline for anti malarials world-wide and is involved in projects ..
- Establishment of a high throughput screen for the discovery of malaria transmissiMatthias Marti; Fiscal Year: 2010..The goal of this work is the discovery of small molecules that could be developed into transmission blocking drugs. ..
- Evaluation of Small Molecule Inhibitors of Hemoglobin Transport as AntimalarialsTheodore F Taraschi; Fiscal Year: 2012..Perturbing the hemoglobin transport system represents a unique approach for developing antimalarials. Given the urgent need for new drug targets and antimalarials and the millions of people worldwide afflicted ..
- Chemical Methods for Ferrous Iron Targeted Drug DeliveryADAM ROBERT RENSLO; Fiscal Year: 2012....
- Exploiting Fatty Acid Metabolism To Cure MalariaDAVID ARMAND FIDOCK; Fiscal Year: 2013..Most currently available antimalarials target the symptomatic blood stage parasites rather than the initial asymptomatic liver stage, while many ..
- Genome Surveillance for drug resistant malariaDyann F Wirth; Fiscal Year: 2010..abstract_text> ..
- Target-Based High-Throughput Screens for Plasmodium falciparum MalariaJon Clardy; Fiscal Year: 2010..Here we will develop a new target-based assay to screen structurally diverse small molecule libraries to identify new antimalarial agents to kill the parasite. ..
- Discovery of Marine Invertebrate-Derived Antimalarial AgentsAmy E Wright; Fiscal Year: 2013....
- Within Host Selection of P. falciparum Variants by Artemisinin Combination TherapJONATHAN JAMES JULIANO; Fiscal Year: 2013..measure, within individual hosts, the true diversity of falciparum infections and the selective pressure of antimalarials. Specifically, we will: i) sequence and quantitate merozoite surface protein-2 (msp2) genotypes within ..
- Dual Function Acridones as A New Antimalarial ChemotypeJane X Kelly; Fiscal Year: 2010..g., respiratory inhibitors and anti-folates), development of drug resistance to quinoline antimalarials has been slow (e.g., chloroquine) or of low order (e.g.,quinine)...
- Genome-wide studies to identify markers of artemisinin-resistant malariaSHANNON TAKALA HARRISON; Fiscal Year: 2013....
- Prenyl Synthase Inhibitors: Novel Anti-Infective AgentsEric Oldfield; Fiscal Year: 2013..Focus will be on developing inhibitors for three unique targets in malaria parasites, and on the use of novel drugs against sleeping sickness. ..
- Identification of Erythrocyte Beta-adrenergic and Gs-mediated PathwaysSebastian Fernandez-Pol; Fiscal Year: 2011..Knowledge concerning malaria invasion may result in the identification of drug targets and subsequent development of antimalarials, thus leading to reduced human suffering from this devastating parasite.
- Aspartic Protease Inhibitors as Novel AntimalarialsMarvin J Meyers; Fiscal Year: 2013..In order to efficiently address the critical need for novel antimalarials, the Center for World Health &Medicine (CWHM) at Saint Louis University has established a research ..
- Mechanism of malaria parasite egress from erythrocytesMay M Paing; Fiscal Year: 2010..Understanding the biology of this important step in infection will provide new strategies for treatment of malaria and development of anti-malarial vaccine. ..
- Essential PK/PD Relationships of Antimalarial and Antitrypanosomal DrugsTheresa A Shapiro; Fiscal Year: 2013..In Aim 1 this new system will be used to describe the essential PK/PDs for selected antimalarials, to determine whether these relationships are class-wide, if they correlate with those for bacteria, and how ..
- Drugs targeting erythrocytic and exoerythrocytic stages of malariaRoman Manetsch; Fiscal Year: 2013..The three chemotypes possess in vivo liver stage activity, in vivo blood stage activity, gametocytocidal activity, and/or activity in the mosquitoes. ..
- Forward genetic screens for identifying antimalarial resistance genesManoj T Duraisingh; Fiscal Year: 2010..knowlesi and P. falciparum parasites, and screened for genes that confer resistance to specific antimalarials. Our system is a novel approach in malaria biology that will have broad application, simultaneously ..
- Genomic Analyses of Plasmodium vivax Responses to Antimalarial Drugs in CambodiaDavid Serre; Fiscal Year: 2013..vivax. Our findings will improve our understanding of drug resistance in this neglected human malaria parasite and have the potential to significantly advance vivax malaria control. ..
- Determine high-resolution structure of membrane protein by single particle cryoEMYifan Cheng; Fiscal Year: 2013..The PfCRT plays a critical role in Plasmodium falciparum resistance to the quinoline antimalarials. We aim to determine the structure of these two proteins to subnanometer resolution and eventually to near ..
- Population biology of malaria drug resistance in YunnanZhaoqing Yang; Fiscal Year: 2010..parasite populations, we propose to (1) systematically evaluate parasite's sensitivity to a wide range of antimalarials;and (2) determine the polymorphisms in known and putative molecular markers of drug targets and evaluate their ..
- Chemical Genomics for Antimalarial TargetsPradipsinh K Rathod; Fiscal Year: 2013..The search for new novel antimalarials relies on a number of approaches including natural products, high-throughput screens, small chemical libraries ..
- TS PROPHYLAXIS AND DRUG-RESISTANT MALARIA IN MALAWICHRISTOPHER PLOWE; Fiscal Year: 2003..Such selection could accelerate the development of Plasmodium falciparum resistance to PS and other antifolate antimalarials in areas where HIV infection and malaria are both highly prevalent...
- The spatial organization of the Plasmodium genome throughout its infectious cycleWilliam Stafford Noble; Fiscal Year: 2013..By providing fundamental insight into the regulatory mechanisms of the malaria parasite, this project will improve our ability to design new drugs and novel lines of defense against malaria. ..
- Molecular Pathways Targeted by Potent Antimalarial Pyrazole CompoundsAkhil B Vaidya; Fiscal Year: 2013..Antimalarial drugs are the mainstay of malaria control, but the spread of parasite resistance to most antimalarials is of grave concern...
- Deciphering apicoplast function during blood stage Plasmodium infectionEllen Yeh; Fiscal Year: 2013..In the face of developing resistance against the current last-line therapy, new antimalarials are desperately needed and a greater understanding of Plasmodium biology will be required to identify viable ..
- Genetic Variation and Evolution of Artemisinin ResistanceDyann F Wirth; Fiscal Year: 2013..Because the emergence of drug resistance threatens to outpace the development of effective new antimalarial drugs, the development of an early warning system for emerging resistance is an essential component to defeating malaria. ..
- Optimizing ELQs for Treatment and Prevention of MalariaMICHAEL KEVIN RISCOE; Fiscal Year: 2012..objective of our proposed work is the development of an inexpensive ELQ that can be co-formulated with other antimalarials in a synergistic combination to prevent and treat malaria, and can serve to assist in eradication of the ..
- Azithromycin Combination Therapy in Resistant MalariaCharles Knirsch; Fiscal Year: 2000..abstract_text> ..
- Preventing Pregnancy Malaria: Maternal-Infant OutcomesMichal Fried; Fiscal Year: 2009..We will also establish a center of excellence for future research on antimalarial interventions in Tanzania. ..
- AZITHROMYCIN TREATMENT FOR DRUG-RESISTANT MALARIAJonathan Berman; Fiscal Year: 2000..4. Test the hypothesis that the best two azithromycin combinations are similarly efficacious in children and pregnant women (assess efficacy and safety in special populations). ..
- IMPACT OF TS PROPHYLAXIS ON ANTIFOLATE RESISTANT MALARIAJames Kublin; Fiscal Year: 2000..falciparum. Such selection could accelerate the development of Plasmodium falciparum resistance to antifolate antimalarials in areas where HIV infection and malaria are both highly prevalent...
- Preclinical Studies of Natural Product Derivatives as Antimalarial AgentsShuren Zhu; Fiscal Year: 2012..falciparum malaria. The novelty of the research is the discovery of new molecular entities. The multidisciplinary team and multi-institution collaboration that has been assembled will accelerate the generation of clinical candidates. ..
- Membrane Permeable Diphosphate Analogs Targeting Pathogen Isoprenoid BiosynthesisCAREN L MEYERS; Fiscal Year: 2013..These studies will provide a foundation for the transformation of highly polar, potent inhibitors of isoprenoid biosynthesis into useful therapeutic agents for the treatment of infectious diseases. ..
- Structural Basis for Isoprenoid BiosynthesisJOSEPH NOEL; Fiscal Year: 2006....
- Falciparum malaria invasion ligand DNA/protein vaccineDavid Narum; Fiscal Year: 2002..S. military has lost more person days to malaria than to bullets (Beadle and Hoffman, 1993). A vaccine against malaria would have enormous domestic and international commercial value. ..
- Indirect aminoacylation in the Plasmodium apicoplastMALCOLM JOHN GARDNER; Fiscal Year: 2010..This research program will characterize a novel Plasmodium biochemical pathway that we believe is essential to parasite survival and therefore a potential target for drug therapy of malaria. ..
- SP resistance markers & falciparum malaria transmissionFabian Mendez; Fiscal Year: 2004..abstract_text> ..
- 7th International Congress on ToxoplasmosisKami Kim; Fiscal Year: 2003..a model organism for studies on all of the Apicomplexa as was highlighted in a recent review on development of antimalarials by Robert Ridley (Nature 2002 Feb 7;415(6872):686-93)...
- PRIMAQUINE-INDUCED HEMOLYTIC ANEMIADAVID MC MILLAN; Fiscal Year: 2004....
- DRUG-RESISTANT MALARIA IN MALAWICHRISTOPHER PLOWE; Fiscal Year: 2002..abstract_text> ..
- Molecular determinants of P. falciparum resistance to ACTs in Nigeria.Christian T Happi; Fiscal Year: 2010..Molecular determinants of parasites responses to antimalarials identified under this project will be used to develop a quick and simple high-throughput PCR-ELISA based tool/..
- New Antimalarials from Plant-Pathogenic FungiNP NANAYAKKARA; Fiscal Year: 2005..The purpose of this proposal is to expand on these results and to identify antimalarial compounds from plant pathogenic fungi and their preliminary evaluation as new clinically useful antimalarial agents. ..
- Clinical trial of chloroquine combinations in MalawiCHRISTOPHER PLOWE; Fiscal Year: 2009..No further delays are anticipated and this extension will permit completion of this ongoing unique and important clinical trial. ..
- Synthesis and Evaluation of Novel Antimalarial AgentsShuren Zhu; Fiscal Year: 2005..An investigational new drug (IND) application will then be filed with FDA. ..
- Institutional Collaboration Between Liverpool STM & CDC on MalariaFeiko ter Kuile; Fiscal Year: 2009..of the interaction between HIV and malaria to a) determine the potential for drug-drug interactions between antimalarials, ARVs and cotrimoxazole prophylaxis in HIV-infected non-pregnant and pregnant individuals in sub-Saharan ..