- Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults
Lionel A Mandell
McMaster University Medical School, Hamilton, Ontario, Canada
Clin Infect Dis 44:S27-72. 2007
- A common mechanism of cellular death induced by bactericidal antibiotics
Michael A Kohanski
Center for BioDynamics and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
Cell 130:797-810. 2007
- Antimicrobial peptides of multicellular organisms
Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104 6059, USA
Nature 415:389-95. 2002
..What sorts of molecules are they? How are they employed by animals in their defence? As our need for new antibiotics becomes more pressing, could we design anti-infective drugs based on the design principles these molecules teach us?..
- Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Kim A Brogden
Department of Periodontics and Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
Nat Rev Microbiol 3:238-50. 2005
..In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented...
- Outpatient antibiotic use in Europe and association with resistance: a cross-national database study
ESAC Management Team, Department of Microbiology, University of Antwerp, B 2610 Antwerp, Belgium
Lancet 365:579-87. 2005
..Our aim was to assess outpatient use of antibiotics and the association with resistance...
- Antibacterial resistance worldwide: causes, challenges and responses
Stuart B Levy
Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Nat Med 10:S122-9. 2004
..Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs...
- Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance
Antimicrobial Research Centre and Division of Microbiology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
Microbiol Mol Biol Rev 65:232-60 ; second page, table of contents. 2001
..Changing the use of tetracyclines in human and animal health as well as in food production is needed if we are to continue to use this class of broad-spectrum antimicrobials through the present century...
- Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli
Department of Biology, Northeastern University, 134 Mugar Hall, 360 Huntington Ave, Boston, MA 02115
J Bacteriol 186:8172-80. 2004
..The function of these specialized dormant cells is to ensure the survival of the population in the presence of lethal factors...
- Typhoid fever
Christopher M Parry
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
N Engl J Med 347:1770-82. 2002
- Extended-spectrum beta-lactamases: a clinical update
David L Paterson
Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Clin Microbiol Rev 18:657-86. 2005
..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...
- Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship
Timothy H Dellit
Harborview Medical Center and the University of Washington, Seattle, USA
Clin Infect Dis 44:159-77. 2007
- Peptide antimicrobial agents
Centre for Microbial Diseases and Immunity Research, University of British Columbia, Lower Mall Research Station, 232 2259 Lower Mall, Vancouver, British Columbia V6T 1Z4, Canada
Clin Microbiol Rev 19:491-511. 2006
..Knowledge regarding the relationship between peptide structure and function as well as their mechanism of action is being applied in the design of antimicrobial peptide variants as potential novel therapeutic agents...
- Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat
P A Bradford
Wyeth Ayerst Research, Pearl River, New York 10965, USA
Clin Microbiol Rev 14:933-51, table of contents. 2001
..They have also been found in other Enterobacteriaceae strains and Pseudomonas aeruginosa. Strains expressing these beta-lactamases will present a host of therapeutic challenges as we head into the 21st century...
- Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillanc
D J Diekema
Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
Clin Infect Dis 32:S114-32. 2001
..Given the increasing multidrug resistance among staphylococci and the possible emergence of vancomycin-resistant strains, global strategies are needed to control emergence and spread of multiply resistant staphylococci...
- Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity
, D-53105 Bonn, Germany
J Biol Chem 276:1772-9. 2001
..The combination of two killing mechanisms in one molecule potentiates antibiotic activity and results in nanomolar MIC values, a strategy that may well be worth considering for the construction of novel antibiotics...
- Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity
Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Que
CMAJ 171:466-72. 2004
..difficile-associated diarrhea (CDAD) in our institution. We describe cases of CDAD at our institution over a 13-year period and investigate changes in illness severity...
- Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
Department of Genetics, Harvard Medical School, Massahusetts General Hospital, Boston, MA 02114, USA
Nature 416:740-3. 2002
..Compounds that affect PvrR function could have an important role in the treatment of CF infections...
- Aminoglycoside antibiotics induce bacterial biofilm formation
Lucas R Hoffman
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Nature 436:1171-5. 2005
..Our results demonstrate that biofilm formation can be a specific, defensive reaction to the presence of antibiotics, and indicate that the molecular basis of this response includes alterations in the level of c-di-GMP...
- The worldwide emergence of plasmid-mediated quinolone resistance
Massachusetts General Hospital, Boston, MA 02114 2696, USA
Lancet Infect Dis 6:629-40. 2006
- Practice guidelines for the diagnosis and management of skin and soft-tissue infections
Dennis L Stevens
Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho 83702, USA
Clin Infect Dis 41:1373-406. 2005
- Recognition of cognate transfer RNA by the 30S ribosomal subunit
J M Ogle
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Science 292:897-902. 2001
..The third, or "wobble," position of the codon is free to accommodate certain noncanonical base pairs. By partially inducing these structural changes, paromomycin facilitates binding of near-cognate tRNAs...
- Mode of action of membrane active antimicrobial peptides
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Biopolymers 66:236-48. 2002
..Further, although many studies support that bacterial membrane damage is a lethal event for bacteria, other studies point to a multihit mechanism in which the peptide binds to several targets in the cytoplasmic region of the bacteria...
- Analysis of a complete library of putative drug transporter genes in Escherichia coli
Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan
J Bacteriol 183:5803-12. 2001
..Of these 20 ORFs, cusA, yegMNO, ydgFE, yceE, yceL, yidY, and ybjYZ are novel drug resistance genes. The fsr, bcr, yjiO, ydhE, acrD, and yhiUV genes gave broader resistance spectra than previously reported...
- Lipopolysaccharide endotoxins
Christian R H Raetz
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA
Annu Rev Biochem 71:635-700. 2002
..The expanding knowledge of TLR4 specificity and its downstream signaling pathways should provide new opportunities for blocking inflammation associated with infection...
- Determination of minimum inhibitory concentrations
J M Andrews
Department of Microbiology, City Hospital NHS Trust, Birmingham B18 7QH, UK
J Antimicrob Chemother 48:5-16. 2001
..Tables giving expected MIC ranges for control NCTC and ATCC strains are also supplied...
- The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms
Biofilm Research Group, University of Calgary, Calgary, Alberta, Canada T2N 1N4
J Clin Microbiol 37:1771-6. 1999
..The CBD offers a new technology for the rational selection of antibiotics effective against microbial biofilms and for the screening of new effective antibiotic compounds...
- Non-inherited antibiotic resistance
Bruce R Levin
Department of Biology, Emory University, Atlanta, Georgia 30307, USA
Nat Rev Microbiol 4:556-62. 2006
- Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in gram-negative bacteria
GBF National Research Centre for Biotechnology, Braunschweig, Federal Republic of Germany
J Bacteriol 172:6557-67. 1990
..g., in open systems and natural environments), and that do not carry antibiotic resistance markers characteristic of most available cloning vectors (as is currently required of live bacterial vaccines)...
- Persister cells and tolerance to antimicrobials
Department of Biology, Northeastern University, Boston, MA 02115, USA
FEMS Microbiol Lett 230:13-8. 2004
..This suggests that persisters are not at a particular stage in the cell cycle, neither are they defective cells nor cells created in response to antibiotics. Our data indicate that persisters are specialized survivor cells...
- The world of subinhibitory antibiotic concentrations
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 01Z3, Canada
Curr Opin Microbiol 9:445-53. 2006
..These analyses should be of value in providing information on antibiotic side-effects, in bioactive natural product discovery and antibiotic mode-of-action studies...
- Infective endocarditis
Institute of Fundamental Microbiology, Centre Hospitalier Universitaire, University of Lausanne, Switzerland
Lancet 363:139-49. 2004
..New ideas for antimicrobial agents are being developed. These novel insights should help redefine preventive and therapeutic strategies against infective endocarditis...
- Efflux-mediated antimicrobial resistance
Department of Microbiology and Immunology, Queen s University, Kingston, ON, Canada
J Antimicrob Chemother 56:20-51. 2005
- SOS response induction by beta-lactams and bacterial defense against antibiotic lethality
Department of Genetics, Stanford University, Stanford, CA 94305, USA
Science 305:1629-31. 2004
- Bacterial persistence as a phenotypic switch
Nathalie Q Balaban
Laboratory of Living Matter and Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Science 305:1622-5. 2004
..Inherent heterogeneity of bacterial populations may be important in adaptation to fluctuating environments and in the persistence of bacterial infections...
- Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community
Department of Bacteriology, Juntendo University, Tokyo, Japan
J Clin Microbiol 40:4289-94. 2002
..They multiplied much faster than health-care-associated MRSA and were resistant to fewer non-beta-lactam antibiotics. They seem to have been derived from more diverse S. aureus populations than health-care-associated MRSA strains...
- Persisters: a distinct physiological state of E. coli
Department of Biology, Northeastern University, 134 Mugar Hall, 360 Huntington Ave, Boston, MA 02115, USA
BMC Microbiol 6:53. 2006
..Recent progress in understanding persisters is encouraging, but the main obstacle in understanding their nature was our inability to isolate these elusive cells from a wild-type population since their discovery in 1944...
- Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report
Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Zentrum fur Innere Medizin, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Gut 56:772-81. 2007
..Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000...
- Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides
Mikrobielle Genetik, Universitat Tubingen, Waldhäuser Strasse 70 8, 72076 Tubingen, Germany
J Biol Chem 274:8405-10. 1999
..We propose a role of the D-alanine-esterified teichoic acids which occur in many pathogenic bacteria in the protection against human and animal defense systems...
- Sampling the antibiotic resistome
Vanessa M D'Costa
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, McMaster University, Ontario, Canada, L8N 3Z5
Science 311:374-7. 2006
..They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms...
- Trends in antimicrobial drug development: implications for the future
Research and Education Institute and Department of Medicine, Harbor University of California, Los Angeles Medical Center, Torrance, California 90502, USA
Clin Infect Dis 38:1279-86. 2004
..Despite the critical need for new antimicrobial agents, the development of these agents is declining. Solutions encouraging and facilitating the development of new antimicrobial agents are needed...
- Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic
Clinical Research Unit, Department of Dermatology, University Hospital Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany
J Biol Chem 276:5707-13. 2001
..hBD-3 therefore might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis...
- Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Jeffrey D Rothstein
Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA
Nature 433:73-7. 2005
..Thus these studies provide a class of potential neurotherapeutics that act to modulate the expression of glutamate neurotransmitter transporters via gene activation...
- Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections
Matthew E Falagas
Alfa Institute of Biomedical Sciences, Athens, Greece
Clin Infect Dis 40:1333-41. 2005
- Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment
Felipe C Cabello
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
Environ Microbiol 8:1137-44. 2006
- Antibiotics as signalling molecules
Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada
Philos Trans R Soc Lond B Biol Sci 362:1195-200. 2007
..Thus, microbial metabolites constitute a large collection of cell-signalling molecules that regulate gene expression in microbial populations and possibly the interactions of these populations with the surrounding organisms...
- The antibiotic resistome: the nexus of chemical and genetic diversity
Gerard D Wright
Antimicrobial Research Centre, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, 1200 Main Street West Hamilton, Ontario, L8N 3Z5, Canada
Nat Rev Microbiol 5:175-86. 2007
..Why is resistance inevitable and where does it come from? Understanding the molecular diversity that underlies resistance will inform our use of these drugs and guide efforts to develop new efficacious antibiotics...
- Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death
Michael A Kohanski
Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, Boston, MA 02215, USA
Cell 135:679-90. 2008
- Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections
G A Pankey
Section of Infectious Diseases, Ochsner Clinic Foundation, New Orleans, Louisiana 70121 2483, USA
Clin Infect Dis 38:864-70. 2004
..The ultimate guide to treatment of any infection must be clinical outcome...
- The patient's role in the spread and control of bacterial resistance to antibiotics
MEMO, University of Dundee, Dundee, UK, Tayside Center for General Practice, Dundee, UK
Clin Microbiol Infect 8:43-68. 2002
..This, in turn, may help to control the development and spread of resistance to antibiotics...
- Multidrug efflux pumps of gram-negative bacteria
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3206, USA
J Bacteriol 178:5853-9. 1996
- Correlation of daptomycin bactericidal activity and membrane depolarization in Staphylococcus aureus
Jared A Silverman
Cubist Pharmaceuticals, Inc, Lexington, Massachusetts 02421, USA
Antimicrob Agents Chemother 47:2538-44. 2003
..This study demonstrates a clear correlation between dissipation of membrane potential and the bactericidal activity of daptomycin. A multistep model for daptomycin's mechanism of action is proposed...
- Molecular mechanisms of antibacterial multidrug resistance
Michael N Alekshun
Schering Plough Research Institute, Kenilworth, NJ 07033, USA
Cell 128:1037-50. 2007
..Once established, multidrug-resistant organisms persist and spread worldwide, causing clinical failures in the treatment of infections and public health crises...
- beta-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus
Departamento de Quimica, Bioquimica y Biologia Molecular, Universidad Cardenal Herrera CEU, 46113 Moncada, Valencia, Spain
J Bacteriol 188:2726-9. 2006
- Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?
David M Livermore
Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, Colindale, London, United Kingdom
Clin Infect Dis 34:634-40. 2002
..A few isolates of P. aeruginosa are resistant to all reliable antibiotics, and this problem seems likely to grow with the emergence of integrins that carry gene cassettes encoding both carbapenemases and amikacin acetyltransferases...
- Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004
Lauri A Hicks
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 196:1346-54. 2007
..The benefits may be offset by increases in disease due to serotypes not included in the vaccine (hereafter, "nonvaccine serotypes"). We evaluated the effect of PCV7 on incidence of disease due to nonvaccine serotypes...
- Antibiotics and antibiotic resistance in water environments
Department of Microbiology, Ramon y Cajal University Hospital, CIBER ESP, Spain
Curr Opin Biotechnol 19:260-5. 2008
..A policy for preventing mixing human-originated and animal-originated bacteria with environmental organisms seems advisable...
- Two-component signal transduction
A M Stock
Center for Advanced Biotechnology and Medicine and Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Annu Rev Biochem 69:183-215. 2000
..Thus detailed analyses of a relatively small number of representative proteins provide a foundation for understanding this large family of signaling proteins...
- Methicillin-resistant S. aureus infections among patients in the emergency department
Gregory J Moran
Department of Emergency Medicine, Olive View UCLA Medical Center, Sylmar, Calif 91342, USA
N Engl J Med 355:666-74. 2006
..Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly recognized in infections among persons in the community without established risk factors for MRSA...
- Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines
W S Lim
Respiratory Infection Research Group, Respiratory Medicine, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
Thorax 56:296-301. 2001
..Atypical pathogens are more common in younger patients. They should also be covered in all patients with severe pneumonia and younger patients with non-severe infection...
- Integrons and gene cassettes in the enterobacteriaceae
P A White
Virology Division, Department of Microbiology, SEALS, Prince of Wales Hospital, Randwick, Sydney NSW 2031, Australia
Antimicrob Agents Chemother 45:2658-61. 2001
..PCR sequencing analysis of the cassette arrays revealed a predominance of cassettes that confer resistance to the aminoglycosides and trimethoprim...
- AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
J Bacteriol 178:306-8. 1996
..This experiment identified the AcrAB system as the major pump responsible for making the Mar mutants resistant to many agents, including tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin...
- SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus
Carlene A Muto
Division of Hospital Epidemiology and Infection Control, UPMC P, Pittsburgh, Pennsylvania 15213, USA
Infect Control Hosp Epidemiol 24:362-86. 2003
..After 2 more years without improvement, a SHEA task force was appointed to draft this evidence-based guideline on preventing nosocomial transmission of such pathogens, focusing on the two considered most out of control: MRSA and VRE...
- Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
Department of Bacteriology, Juntendo University, Tokyo, Japan
Lancet 350:1670-3. 1997
..Two important questions need to be answered: (1) what is the prevalence of VRSA, and (2) by what mechanism does vancomycin resistance occur...
- A European study on the relationship between antimicrobial use and antimicrobial resistance
Stef L A M Bronzwaer
National Institute of Public Health and the Environment, Department of Infectious Disease Epidemiology, Postbak 75, PO Box 1, Antonie van Leeuwenhoeklaan 9, 3720 BA Bilthoven, The Netherlands
Emerg Infect Dis 8:278-82. 2002
..Our results show that in Europe antimicrobial resistance of S. pneumoniae to penicillin is correlated with use of beta-lactam antibiotics and macrolides...
- Antimicrobial use and antimicrobial resistance: a population perspective
Department of Epidemiology, Harvard School of Public Health, Boston, Massachussetts 02115, USA
Emerg Infect Dis 8:347-54. 2002
..These mechanisms can operate even when treatment has a modest, or even negative, effect on an individual host's colonization with resistant organisms...
- Rapid dissemination and diversity of CTX-M extended-spectrum beta-lactamase genes in commensal Escherichia coli isolates from healthy children from low-resource settings in Latin America
Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Universita di Siena, Policlinico Santa Maria alle Scotte, Siena, Italy
Antimicrob Agents Chemother 51:2720-5. 2007
..Three CTX-M-15-encoding conjugative plasmids from Peruvian isolates carried the new fluoroquinolone resistance gene aac(6')-Ib-cr. To our best knowledge, this is the first report of the detection of aac(6')-Ib-cr in Latin America...
- The biological cost of antibiotic resistance
D I Andersson
Department of Bacteriology Swedish Institute for Infectious Disease Control S 17182, Solna, Sweden
Curr Opin Microbiol 2:489-93. 1999
..The data available from recent laboratory studies suggest that most, but not all, resistance-determining mutations and accessory elements engender some fitness cost, but those costs are likely to be ameliorated by subsequent evolution...
- The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions
Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 97:1938-43. 2000
..The predictions of the model are compared with those of other models and published data. The implications for resistance control and study design are discussed, along with the limitations and assumptions of the model...
- Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis
Department of Clinical Neurosciences, University of Calgary, Canada
Brain 125:1297-308. 2002
..These results indicate that minocycline may constitute a safe and inexpensive therapy for multiple sclerosis...
- Effect of pneumonia case management on mortality in neonates, infants, and preschool children: a meta-analysis of community-based trials
Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Lancet Infect Dis 3:547-56. 2003
..Community-based interventions to identify and treat pneumonia have a substantial effect on neonatal, infant, and child mortality and should be incorporated into primary health care...
- Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics
Ee Been Goh
Department of Microbiology and Immunology, University of British Columbia, 300 6174 University Boulevard, Vancouver, BC, Canada V6T 1Z3
Proc Natl Acad Sci U S A 99:17025-30. 2002
- Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
Antimicrob Agents Chemother 46:1492-502. 2002
..These findings imply that compromised agr function is advantageous to clinical isolates of S. aureus toward the development of vancomycin heteroresistance, perhaps through the development of vancomycin tolerance...
- Otitis media
Maroeska M Rovers
Julius Centre for Health Sciences and Primary Care, University Medical Centre, PO Box 85060, 3508 AB, Utrecht, Netherlands
Lancet 363:465-73. 2004
..The ideal intervention for OM, however, does not yet exist, and an urgent need remains to explore new and creative options based on modern insights into the pathophysiology of OM...
- Detection of erythromycin-resistant determinants by PCR
Department of Infectious Diseases, Pfizer, Inc, Groton, Connecticut 06340, USA
Antimicrob Agents Chemother 40:2562-6. 1996
..Further, this methodology could be useful in surveillance studies of erythromycin-resistant determinants...
- A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria
J N Eloff
Department of Pharmacology, University of Pretoria, South Africa
Planta Med 64:711-3. 1998
..MIC values determined for sulfisoxazole, norfloxacin, gentamicin, and nitrofuratoin were similar to values indicated in the literature but values obtained with trimethroprim and ampicillin were higher with some bacteria...
- Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial
Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WCIE 7HT
BMJ 334:403. 2007
..To compare rapid diagnostic tests (RDTs) for malaria with routine microscopy in guiding treatment decisions for febrile patients...
- Resistance in gram-negative bacteria: enterobacteriaceae
David L Paterson
Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Med 119:S20-8; discussion S62-70. 2006
..Better antibiotic stewardship and infection control are needed to prevent further spread of ESBLs and other forms of resistance in Enterobacteriaceae throughout the world...
- Predicting the clinical course of suspected acute viral upper respiratory tract infection in children
Christopher C Butler
Department of General Practice, Cardiff University, Llanedeyrn Health Centre, Cardiff CF23 9PN, UK
Fam Pract 22:92-5. 2005
- Methicillin-resistant Staphylococcus aureus: an evolutionary, epidemiologic, and therapeutic odyssey
Division of Infectious Disease and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA, USA
Clin Infect Dis 40:562-73. 2005
..This has led to an important change in the choice of antibiotics in the management of community-acquired infections and has also led to the development of novel antimicrobials...
- A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use
Carlene A Muto
Division of Hospital Epidemiology and Infection Control, University of Pittsburgh Medical Center, Presbyterian Campus, Pittsburgh, Pennsylvania 15213, USA
Infect Control Hosp Epidemiol 26:273-80. 2005
..difficile infections; of these, 26 resulted in colectomy and 18 resulted in death. We conducted an investigation of a large C. difficile outbreak in our hospital to identify risk factors and characterize the outbreak...
- Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group
Department of Internal Medicine, University Hospitals, Basel, Switzerland
JAMA 279:1537-41. 1998
..Rifampin-containing regimens are able to cure staphylococcal implant-related infections based on in vitro and in vivo observations. However, this evidence has not been proven by a controlled clinical trial...
- The new beta-lactamases
George A Jacoby
Department of Infectious Diseases, Lahey Clinic, Burlington, Mass 01805, USA
N Engl J Med 352:380-91. 2005
- Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network
MRC SAIMR Wits Pneumococcal Diseases Research Unit, Johannesburg, South Africa
J Clin Microbiol 39:2565-71. 2001
..This network can serve as a prototype for the collaboration of scientists in identifying clones of important human pathogens and as a model for the development of other networks...
- Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
Matthew R Moore
Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
J Infect Dis 197:1016-27. 2008
..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
- Characterization of multiple-antimicrobial-resistant Escherichia coli isolates from diseased chickens and swine in China
China Agricultural University, Beijing, China
J Clin Microbiol 42:3483-9. 2004
- Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms
Center for Biofilm Engineering and Department of Chemical Engineering, Montana State University Bozeman, Bozeman, MT 59717 3980, USA
Antimicrob Agents Chemother 48:2659-64. 2004
..Local oxygen limitation and the presence of nitrate may contribute to the reduced susceptibilities of P. aeruginosa biofilms causing infections in vivo...
- Impact of imipenem resistance on mortality in patients with Acinetobacter bacteraemia
Ki Tae Kwon
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Seoul 135 710, Korea
J Antimicrob Chemother 59:525-30. 2007
..To investigate the impact of imipenem resistance on the mortality rate among patients with Acinetobacter bacteraemia...
- Synergism between natural products and antibiotics against infectious diseases
Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, India
Phytomedicine 15:639-52. 2008
..The mode of action of combination differs significantly than that of the same drugs acting individually; hence isolating a single component may lose its importance thereby simplifying the task of pharma industries...
- Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp
Institut Nationale de la Santé et de la Recherche Médicale Unité 914, Le Kremlin Bicetre, France
Emerg Infect Dis 14:231-7. 2008
..This identification of plasmid-mediated qnr genes outside Enterobacteriaceae underlines a possible diffusion of those resistance determinants within gram-negative rods...
- Bistability in bacteria
Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA
Mol Microbiol 61:564-72. 2006
..A review describing additional examples of bistability in bacteria has been published recently...
- Carbapenemases: the versatile beta-lactamases
Anne Marie Queenan
Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
Clin Microbiol Rev 20:440-58, table of contents. 2007
..This review updates the characteristics, epidemiology, and detection of the carbapenemases found in pathogenic bacteria...
- Survey of resistance of Pseudomonas aeruginosa from UK patients with cystic fibrosis to six commonly prescribed antimicrobial agents
T L Pitt
Laboratory of HealthCare Associated Infection, Specialist and Reference Microbiology Division, Health Protection Agency, 61 Colindale Avenue, London NW9 5HT, UK
Thorax 58:794-6. 2003
..Respiratory infection with Pseudomonas aeruginosa is very common in patients with cystic fibrosis (CF) but antimicrobial resistance rates of CF isolates across the UK are largely unknown...
- The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections
James A Driscoll
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA
Drugs 67:351-68. 2007
..Multidrug-resistant P. aeruginosa may require treatment with less commonly used antibacterials (e.g. colistin), but newer anti-pseudomonal antibacterials are expected to be available in the near future...
- Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization
Rebecca H Sunenshine
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 13:97-103. 2007
..5, 95% CI 1.2-5.4 and OR 4.2, 95% CI 1.5-11.6] respectively). Increased hospitalization associated with MDR Acinetobacter infection emphasizes the need for infection control strategies to prevent cross-transmission in healthcare settings...
- Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America
Alan L Bisno
Department of Medicine, University of Miami School of Medicine and Veterans Affairs Medical Center, Miami, FL 33125, USA
Clin Infect Dis 35:113-25. 2002
- Transcriptional profiling reveals that daptomycin induces the Staphylococcus aureus cell wall stress stimulon and genes responsive to membrane depolarization
Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, IL 61790 4120, USA
Antimicrob Agents Chemother 52:980-90. 2008
..The results indicate that inhibition of peptidoglycan biosynthesis, either directly or indirectly, and membrane depolarization are parts of the mode of action of daptomycin...
- A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment
Ajit K Sarmah
Landcare Research New Zealand Limited, Private Bag 3127, Hamilton, New Zealand
Chemosphere 65:725-59. 2006
..The final section highlights some unresolved questions and presents a way forward on issues requiring urgent attention...
- Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?
Kyle J Popovich
Division of Infectious Disease, Department of Medicine, Rush University Medical Center, and Division of Infectious Disease, Department of Medicine, Stroger Hospital of Cook County, Chicago, Illinois 60612, USA
Clin Infect Dis 46:787-94. 2008
..We describe the epidemiology of hospital-onset community-associated MRSA bloodstream infections using phenotypic and genotypic analysis...
- Antimicrobial drug use and resistance in Europe
Nienke van de Sande-Bruinsma
National Institute of Public Health and the Environment, Bilthoven, The Netherlands
Emerg Infect Dis 14:1722-30. 2008
..Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe...
- Inflammatory bowel disease
Daniel K Podolsky
Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, USA
N Engl J Med 347:417-29. 2002
- Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa
Mette E Skindersoe
Biomedical Microbiology, BioSys, Technical University of Denmark, Kgs Lyngby DK 2800, Denmark
Antimicrob Agents Chemother 52:3648-63. 2008
..The data suggest that the underlying mechanism may be mediated by changes in membrane permeability, thereby influencing the flux of N-3-oxo-dodecanoyl-L-homoserine lactone...