tartrates

Summary

Top Publications

  1. ncbi Anaerobic growth of Escherichia coli on D-tartrate depends on the fumarate carrier DcuB and fumarase, rather than the L-tartrate carrier TtdT and L-tartrate dehydratase
    Ok Bin Kim
    Institut für Mikrobiologie und Weinforschung, Universitat Mainz, Becherweg 15, 55099 Mainz, Germany
    Arch Microbiol 188:583-9. 2007
  2. pmc L-tartaric acid synthesis from vitamin C in higher plants
    Seth DeBolt
    School of Agriculture, Food, and Wine, University of Adelaide, Adelaide, SA 5005, Australia
    Proc Natl Acad Sci U S A 103:5608-13. 2006
  3. ncbi Effect of organic acids on adsorption and desorption of rare earth elements
    Xiao Quan Shan
    Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing
    Chemosphere 47:701-10. 2002
  4. ncbi Organic acids influence iron uptake in the human epithelial cell line Caco-2
    Susan Salovaara
    Department of Food Science, Chalmers University of Technology, P O Box 5401, SE 402 29 Goteborg, Sweden
    J Agric Food Chem 50:6233-8. 2002
  5. ncbi [Simultaneous determination of eight organic acids in Fructus mume by RP-HPLC]
    Zhan Guo Chen
    College of Chemistry and Materials Science, Shaaxi Normal University, Xi an 710062, China
    Zhongguo Zhong Yao Za Zhi 31:1783-6. 2006
  6. ncbi Simultaneous and direct determination of oxalic acid, tartaric acid, malic acid, vitamin C, citric acid, and succinic acid in Fructus mume by reversed-phase high-performance liquid chromatography
    Chen Zhanguo
    Department of Chemistry, School of Chemistry and Material Science, Shaanxi Normal University, Xi an, PR China
    J Chromatogr Sci 40:35-9. 2002
  7. ncbi Effect of organic acids and hydrogen peroxide on Cryptosporidium parvum viability in fruit juices
    Kalmia E Kniel
    Department of Food Science and Technology, Virginia Tech, Blacksburg, Virginia, USA
    J Food Prot 66:1650-7. 2003
  8. ncbi Erosive effects of different acids on bovine enamel: release of calcium and phosphate in vitro
    Christian Hannig
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Arch Oral Biol 50:541-52. 2005
  9. ncbi Gas chromatographic determination of organic acids from fruit juices by combined resin mediated methylation and extraction in supercritical carbon dioxide
    T J Barden
    Australian Government Analytical Laboratories, Pymble, NSW 2073, Australia
    J Chromatogr A 785:251-61. 1997
  10. ncbi Desorption of copper and cadmium from soils enhanced by organic acids
    Songhu Yuan
    Environmental Science Research Institute, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Chemosphere 68:1289-97. 2007

Research Grants

  1. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005
  2. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
  3. REDUCED DRUG INTERACTIONS OF AZOLE ANTIFUNGAL DRUGS
    Joseph Gal; Fiscal Year: 2003
  4. Synthesis of Novel Anticancer Agents
    MARISA KOZLOWSKI; Fiscal Year: 2007
  5. STRUCTURE OF VIRAL RNA AND ITS ROLE IN ASSEMBLY
    Alexander McPherson; Fiscal Year: 2006
  6. Designing Asymmetric Ligands Using Computational Techniques
    MARISA KOZLOWSKI; Fiscal Year: 2009
  7. Preparing high resolution membrane protein crystals
    Zygmunt Derewenda; Fiscal Year: 2005
  8. Rapid protein crystallization by surface mutagenesis
    Zygmunt Derewenda; Fiscal Year: 2004
  9. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
  10. Novel Amino Acid-Based Glass-Ionomer Biomaterials
    Dong Xie; Fiscal Year: 2005

Detail Information

Publications187 found, 100 shown here

  1. ncbi Anaerobic growth of Escherichia coli on D-tartrate depends on the fumarate carrier DcuB and fumarase, rather than the L-tartrate carrier TtdT and L-tartrate dehydratase
    Ok Bin Kim
    Institut für Mikrobiologie und Weinforschung, Universitat Mainz, Becherweg 15, 55099 Mainz, Germany
    Arch Microbiol 188:583-9. 2007
    ..No D-tartrate specific carriers and enzymes are involved in the pathway...
  2. pmc L-tartaric acid synthesis from vitamin C in higher plants
    Seth DeBolt
    School of Agriculture, Food, and Wine, University of Adelaide, Adelaide, SA 5005, Australia
    Proc Natl Acad Sci U S A 103:5608-13. 2006
    ....
  3. ncbi Effect of organic acids on adsorption and desorption of rare earth elements
    Xiao Quan Shan
    Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing
    Chemosphere 47:701-10. 2002
    ..5. The reasons for this were ascribed to the strong complexing capacity of citric and malic acids and low soil pH, CEC and organic matter of Jiangxi soil...
  4. ncbi Organic acids influence iron uptake in the human epithelial cell line Caco-2
    Susan Salovaara
    Department of Food Science, Chalmers University of Technology, P O Box 5401, SE 402 29 Goteborg, Sweden
    J Agric Food Chem 50:6233-8. 2002
    ..The results may be important for elucidating factors affecting iron bioavailability in the small intestine and for the development of foods with improved iron bioavailability...
  5. ncbi [Simultaneous determination of eight organic acids in Fructus mume by RP-HPLC]
    Zhan Guo Chen
    College of Chemistry and Materials Science, Shaaxi Normal University, Xi an 710062, China
    Zhongguo Zhong Yao Za Zhi 31:1783-6. 2006
    ..To develop an HPLC method for the simultaneous separation and determination of oxalic acid (OA), tartaric acid(TA), malic acid(MA), vitamin C (VC), lactic acid (LA), acetic acid (AA) citric acid (CA) and succinic acid (SA) in Fructus mume...
  6. ncbi Simultaneous and direct determination of oxalic acid, tartaric acid, malic acid, vitamin C, citric acid, and succinic acid in Fructus mume by reversed-phase high-performance liquid chromatography
    Chen Zhanguo
    Department of Chemistry, School of Chemistry and Material Science, Shaanxi Normal University, Xi an, PR China
    J Chromatogr Sci 40:35-9. 2002
    ..The method can be used for the purpose of routine analysis and the quality control of a botanic (Fructus mume) containing these effective components...
  7. ncbi Effect of organic acids and hydrogen peroxide on Cryptosporidium parvum viability in fruit juices
    Kalmia E Kniel
    Department of Food Science and Technology, Virginia Tech, Blacksburg, Virginia, USA
    J Food Prot 66:1650-7. 2003
    ..The addition of low concentrations of H2O2 can represent a valuable alternative to pasteurization...
  8. ncbi Erosive effects of different acids on bovine enamel: release of calcium and phosphate in vitro
    Christian Hannig
    Department of Operative Dentistry, Preventive Dentistry and Periodontology, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Arch Oral Biol 50:541-52. 2005
    ..During short time exposition at constant pH level, erosive effects mainly depend on pH and type of acid but not on amount of titratable acid...
  9. ncbi Gas chromatographic determination of organic acids from fruit juices by combined resin mediated methylation and extraction in supercritical carbon dioxide
    T J Barden
    Australian Government Analytical Laboratories, Pymble, NSW 2073, Australia
    J Chromatogr A 785:251-61. 1997
    ..A simple new technique for the determination of citric/isocitric acid ratio is now available. Also, in contrast to HPLC methods, the identity of an analyte is readily confirmed by GC-MS...
  10. ncbi Desorption of copper and cadmium from soils enhanced by organic acids
    Songhu Yuan
    Environmental Science Research Institute, Huazhong University of Science and Technology, Wuhan 430074, PR China
    Chemosphere 68:1289-97. 2007
    ..The net effect determined the desorption efficiency. This study provided guidance for the selection of organic acids to enhance the electrokinetic (EK) remediation of copper and cadmium from contaminated soils...
  11. ncbi Combined impact of pH and organic acids on iron uptake by Caco-2 cells
    Susan Salovaara
    Department of Chemistry and Bioscience, Chalmers University of Technology, PO Box 5401, SE 402 29 Goteborg, Sweden
    J Agric Food Chem 51:7820-4. 2003
    ..For ferric iron the organic acids promoted uptake both by chelation and by lowering the pH, whereas for ferrous iron the promoting effect was caused only by the lowered pH...
  12. ncbi High-performance liquid chromatographic separation and quantification of citric, lactic, malic, oxalic and tartaric acids using a post-column photochemical reaction and chemiluminescence detection
    Tomás Pérez-Ruiz
    Department of Analytical Chemistry, Faculty of Chemistry University of Murcia, 30071 Murcia, Spain
    J Chromatogr A 1026:57-64. 2004
    ..The applicability of the assay was demonstrated by analysing these compounds in real samples such as milk, fruit juices, soft drinks, wine and beer...
  13. ncbi An improved method for the extraction of low molecular weight organic acids in variable charge soils
    XingXiang Wang
    Institute of Soil Science, Chinese Academy of Sciences, China
    Anal Sci 23:539-43. 2007
    ..Simultaneously, the LMWOAs in Agri-Udic Ferrosol with field moisture were measured with a satisfactory result...
  14. ncbi Enhancement effect study of some organic acids on the calcium availability of vegetables: application of the dynamic in vitro simulated gastrointestinal digestion method with continuous-flow dialysis
    Juwadee Shiowatana
    Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Agric Food Chem 54:9010-6. 2006
    ..An enhancement effect from added organic acids was not clearly observed for Chinese kale, which itself contains a high amount of available calcium (52.9%)...
  15. ncbi A naked-eye sensing ensemble for the selective detection of citrate--but not tartrate or malate--in water based on a tris-cationic receptor
    Carsten Schmuck
    Universitat Wurzburg, Institut fur Organische Chemie, Am Hubland, 97074 Wurzburg, Germany
    Org Biomol Chem 4:836-8. 2006
    ..Citrate 3 can be selectively detected in aqueous solvents even in the presence of malate or tartrate using a naked-eye detection system based on the complex between tris-cation 1 and carboxyfluorescein 2...
  16. ncbi The hygroscopic properties of dicarboxylic and multifunctional acids: measurements and UNIFAC predictions
    C Peng
    Department of Chemical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon
    Environ Sci Technol 35:4495-501. 2001
    ..The modified UNIFAC model improves the agreement of predictions and measurements to within 38% for all the acids studied...
  17. ncbi Development and validation of a capillary electrophoresis method for direct measurement of isocitric, citric, tartaric and malic acids as adulteration markers in orange juice
    L Saavedra
    , Universidad San Pablo-CEU, , Madrid, Spain
    J Chromatogr A 881:395-401. 2000
    ..Detection was direct UV at 200 nm. Different kinds and marks of orange juice, chosen from the great variety existent in the market, were analysed and clear differences could be found between them and just pressed orange juice...
  18. ncbi Comparative analysis of influence of promoters and inhibitors on in vitro available iron using two methods
    A Jyothi Lakshmi
    Department of Studies in Food Science and Nutrition, Manasagangothri, University of Mysore, Mysore, India
    Int J Food Sci Nutr 57:559-69. 2006
    ..The overall observations showed that although absolute values varied widely, a positive correlation existed between the methods...
  19. ncbi Effects of exogenous chelators on phytoavailability and toxicity of Pb in Zinnia elegans Jacq
    Shuang Cui
    Key Laboratory of Terrestrial Ecological Process, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China
    J Hazard Mater 146:341-6. 2007
    ..Thus, chelating agents in their appropriately concentrations could counteract Pb toxicity, but superfluous chelators resulted in less Pb uptake and growth inhibition of the seedlings...
  20. ncbi Influence of organic ligands on Cr desorption from hydroxy-Cr intercalated montmorillonite
    William E Dubbin
    Department of Mineralogy, The Natural History Museum, London SW7 5BD, UK
    Chemosphere 54:1071-7. 2004
    ..Oxalate, tartrate, and citrate were shown to be effective chelators of sorbed Cr and these ligands may therefore play an important role in the mobilisation and cycling of this metal in soils and sediments...
  21. ncbi [Microbial biomass affected by cadmium with the occurrence of organic acids in red soil]
    Min Liao
    College of Environmental Sciences and Natural Resources, Zhejiang University, Hangzhou 310029
    Ying Yong Sheng Tai Xue Bao 13:300-2. 2002
    ..However, the C:N ratio of soil microbial biomass was increased with increasing concentration of cadmium. Organic acids could increase microbial biomass carbon and nitrogen when soil was not added with cadmium...
  22. ncbi Packed column supercritical fluid chromatography of a peroxysome proliferator-activating receptor agonist drug. Achiral and chiral purity of substance, formulation assay and its enantiomeric purity
    Olle Gyllenhaal
    Analytical Development, AstraZeneca R and D Molndal, S 431 83 Molndal, Sweden
    J Chromatogr A 1042:173-80. 2004
    ..The minor enantiomer at the 3% (w/w) level added could be confirmed. Its ratio remained constant during the procedure as measured relative to a reference solution in organic media...
  23. ncbi Chiral separation of sympathomimetics and beta-blockers by ligand-exchange CE using Cu(II) complexes of L-tartaric acid and L-threonine as chiral selectors
    Heike Hödl
    Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, Karl Franzens University, Graz, Austria
    Electrophoresis 28:2675-82. 2007
    ..Using Cu(II) ions as a complexing agent, a series of sympathomimetics and beta-blockers were resolved. It was found that the resolution strongly depends on selector concentration and pH. The optimum pH for complexation was 12...
  24. ncbi High-performance liquid chromatographic separation of rolipram, bupivacaine and omeprazole using a tartardiamide-based stationary phase influence of flow rate and temperature on the enantioseparation
    Ivanildo José da Silva Junior
    Department of Biotechnological Processes, School of Chemical Engineering, State University of Campinas UNICAMP, P O Box 6066, 13083 970 Campinas SP, Brazil
    J Chromatogr A 1162:97-102. 2007
    ..Van't Hoff plots provided the thermodynamic data. The variation of the thermodynamic parameters enthalpy and entropy are clearly negative meaning that the separation is enthalpy controlled...
  25. pmc Determination of enantiomeric compositions of analytes using novel fluorescent chiral molecular micelles and steady state fluorescence measurements
    Alicia A Williams
    Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA
    J Fluoresc 18:285-96. 2008
    ..Prediction ability was evaluated by use of the root-mean-square percent relative error (RMS%RE) and was found to range from 2.04 to 4.06%...
  26. ncbi The first and second cinchona rearrangement. Two fundamental transformations of alkaloid chemistry
    M Heiko Franz
    Department of Organic Chemistry, University of Hannover, Schneiderberg 1 B, 30167 Hannover, Germany
    J Org Chem 69:2983-91. 2004
    ..Stereoelectronic factors, electron demand at C9, ground state conformation, and solvent type are crucial in all cases. A two-step protocol for preparing 9-epi-configured Cinchona alkaloids from 9-nat precursors is described...
  27. ncbi Purpurinimide-fullerene dyads: introduction of fullerene moiety at various peripheral positions of the purpurinimide system
    Guolin Li
    Photodynamic Therapy Center and the Department of Nuclear Medicine and Radiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Org Lett 6:2393-6. 2004
    ..Remarkably different effects of the position of the fullerene moiety in the formation of atropisomers were observed...
  28. ncbi Total syntheses of naturally occurring diacetylenic spiroacetal enol ethers
    Naoki Miyakoshi
    Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    J Org Chem 70:6045-52. 2005
    ..The newly developed procedures could be successfully applied to the first total synthesis of five diacetylenic spiroacetal enol ether natural products starting from commercially available (R,R)- or (S,S)-diethyl tartrate...
  29. ncbi Exceptional chiral recognition of racemic carboxylic acids by calix[4]arenes bearing optically pure alpha,beta-amino alcohol groups
    Yan Song Zheng
    Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, P R China
    Org Lett 6:1189-92. 2004
    ..structure: see text]..
  30. ncbi Practical asymmetric synthesis of a gamma-secretase inhibitor exploiting substrate-controlled intramolecular nitrile oxide-olefin cycloaddition
    Jeremy P Scott
    Department of Process Research, Merck Sharp and Dohme Research Laboratories, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, United Kingdom
    J Org Chem 71:3086-92. 2006
    ..Kilogram quantities of the targeted drug candidate (-)-1 were obtained, without recourse to chromatography, by way of 10 isolated intermediates and in 13% overall yield...
  31. ncbi Catalytic asymmetric synthesis of a nitrogen analogue of dialkyl tartrate by direct mannich reaction under phase-transfer conditions
    Takashi Ooi
    Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    Org Lett 6:2397-9. 2004
    ..This methodology enables the catalytic asymmetric synthesis of differentially protected 3-aminoaspartate, a nitrogen analogue of dialkyl tartrate. The product (syn-5) was converted into a precursor (6) of streptolidine lactam...
  32. ncbi Formation of chiral surface with enantiomeric tartaric acid on gemini-structured self-assembled monolayers
    Shinobu Yokokawa
    Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama, Kanagawa 226 8502, Japan
    J Nanosci Nanotechnol 6:1772-8. 2006
    ..Our results imply a preferential crystalline growth of chiral molecules on the same chiral surface, which may lead to a work for optical resolution into two enantiomers at a solid-liquid interface...
  33. ncbi Investigation of a tartaric acid-based linear polyamide and dimer as chiral selectors in liquid chromatography
    Joakim Oxelbark
    Department of Chemistry, Goteborg University, Goteborg, Sweden
    Chirality 17:79-84. 2005
    ..The linear polyamide showed lower enantioselectivity and higher retention than Kromasil CHI-DMB...
  34. ncbi Alfred Werner's inorganic counterparts of racemic and mesomeric tartaric acid: a milestone revisited
    W Gregory Jackson
    Department of Chemistry, School of Physical, Environmental and Mathematical Sciences, University College UNSW, Australian Defence Force Academy, Northcott Drive, Canberra, ACT, Australia 2600
    Inorg Chem 43:6249-54. 2004
    ..The nitro bridge is unsymmetrically N-O bonded, and each dinuclear ion is therefore asymmetric, a fact also clearly apparent in the (1)H and (13)C NMR spectra...
  35. ncbi Chiral C(2)-symmetric ligands with 1,4-dioxane backbone derived from tartrates: syntheses and applications in asymmetric hydrogenation
    Wenge Li
    Department of Chemistry, The Pennsylvania State University, University Park 16802, USA
    J Org Chem 67:7618-23. 2002
    Chiral 1,4-diphenylphosphines 5-7 as well as thioether 8 were synthesized from tartrates employing Ley's "BDA" and "Dispoke" methodologies as the key step...
  36. ncbi Studies into the stereoselectivity of tartrate-derived dienophiles
    Wei Der Lee
    Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, USA
    Org Lett 7:1687-9. 2005
    ..Complementary diastereoselectivity is observed depending on the nature of the 1,2-diol protecting group incorporated in these dienophiles...
  37. ncbi Total stereoselective synthesis of (+)-goniothalesdiol
    M Carmen Carreño
    Departamento de Quimica Organica C I, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Org Lett 7:5517-20. 2005
    ....
  38. ncbi Prostatic acid phosphatase: structural aspects of inhibition by L-(+)-tartrate ions
    L Lovelace
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia 29208, USA
    Acta Biochim Pol 44:673-8. 1997
    ..Chem., 1993, 268, 20744-20746) contains the model of the ligand with incorrect chirality. We report here the correct model and discuss the relation between this model and the model of the inhibitory complexes between PAP and oxy-anions...
  39. ncbi Determination of acids and volatile compounds in red Txakoli wine by high-performance liquid chromatography and gas chromatography
    A Escobal
    , Facultad de Ciencias, , Bilbao, Spain
    J Chromatogr A 823:349-54. 1998
    ..The major differences observed in the samples obtained from Hondarrabi Beltza variety are their higher contents in ethanol, propanol, ethyl acetate and tartaric and malic acids...
  40. ncbi From chiral counterions to twisted membranes
    Damien Berthier
    Institut Europeen de Chimie et Biologie, 16 Av Pey Berland, 33607 Pessac Cedex, France
    J Am Chem Soc 124:13486-94. 2002
    ..Our work also includes the first application of vibrational circular dichroism in the study of chiral conformations of amphiphiles in membranes and demonstrates the very high potential of this technique...
  41. ncbi Rapid separation and analysis of six organic acids in Bayer liquors by RP-HPLC after solid-phase extraction
    Jian Bo Xiao
    College of Chemistry and Chemical Engineering, Central South University, 410083 Changsha, China
    Ann Chim 96:347-54. 2006
    ..80% and < 3.74%, respectively. The accuracy of the method was confirmed with an average recovery ranging between 85.2 and 107.3%. Under optimum conditions the detection limits ranged from 50 to 1000 mg/L...
  42. ncbi Identification of the L-tartrate dehydratase genes (ttdA and ttdB) of Escherichia coli and evolutionary relationship with the class I fumarase genes
    S K Reaney
    Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, University of Sheffield, UK
    J Gen Microbiol 139:1523-30. 1993
    ..E. coli can use L-, D- and meso-tartrates as aerobic growth substrates and as reducible substrates for supporting anaerobic growth on glycerol...
  43. ncbi Computer-aided design of chiral ligands. Part 2. Functionality mapping as a method to identify stereocontrol elements for asymmetric reactions
    Marisa C Kozlowski
    Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Org Chem 68:2061-76. 2003
    ..including the Masamune dimethylborolane, dimenthylborane, the Corey stien reagent, the Roush allylboronate tartrates, and the secondary amine Diels-Alder catalysts described by MacMillan...
  44. ncbi Synthesis, conformation and chiroptical properties of diaryl esters of tartaric acid
    Robert Cysewski
    Department of Chemistry, Adam Mickiewicz University, 60 780 Poznan, Poland
    J Org Chem 74:4573-83. 2009
    ..Dinaphthyl tartrates show unusually strong exciton Cotton effects (A = -228 for di-1-naphthyl l-tartrate) due to the coupling of ..
  45. ncbi Chiral separation by enantioselective liquid-liquid extraction
    Boelo Schuur
    University of Groningen, Chemical Engineering Department, Nijenborgh 4, 9747 AG, Groningen, The Netherlands
    Org Biomol Chem 9:36-51. 2011
    ..The following extractant classes are considered: crown ether based extractants, metal complexes and metalloids, extractants based on tartrates, and a final section with all other types of chiral extractants.
  46. ncbi Tartric acid-based linker for the solid-phase synthesis of C-terminal peptide alpha-oxo aldehydes
    O Melnyk
    UMR 8525 CNRS Institut Pasteur de Lille Université de Lille 2, Institut de Biologie de Lille, 1 rue du Professeur Calmette, 59019 Lille, France
    J Org Chem 66:4153-60. 2001
    ..The C-terminal peptide alpha-oxo aldehydes synthesized in this study were found to be useful partners in hydrazone, thiazolidine, and oxime chemical ligations...
  47. ncbi Mechanism of change in enantiomer migration order of enantioseparation of tartaric acid by ligand exchange capillary electrophoresis with Cu(II) and Ni(II)-D-quinic acid systems
    Sen ichi Aizawa
    Graduate School of Science and Engineering, University of Toyama, Gofuku, Toyama, Japan
    Electrophoresis 33:523-7. 2012
    ....
  48. ncbi Bioplastics from feather quill
    Aman Ullah
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    Biomacromolecules 12:3826-32. 2011
    ..Propylene glycol and diethyl tartrate exhibited lower H-bonding interactions and showed wide transition regions in DMA profiles during heating, suggesting weak and heterogeneous interactions between quill keratin and these plasticizers...
  49. ncbi The effect of the presence of metatartaric acid on removal effectiveness of heavy metal ions on chelating ion exchangers
    Zbigniew Hubicki
    Department of Inorganic Chemistry, Faculty of Chemistry, Maria Curie Sklodowska University, Maria Curie Sklodowska Sq 2, 20 031 Lublin, Poland
    Environ Technol 32:805-16. 2011
    ..Temperature does not affect the sorption process significantly. The sorption data were well fitted by the Langmuir adsorption model whereas kinetics of the sorption process was well described by the pseudo second order kinetics equation...
  50. pmc Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling
    Qipeng Fan
    Wells Center for Pediatric Research, Department of Pediatrics and The Simon Cancer Center, Indiana University, Indianapolis, IN 46202, USA
    Chin J Cancer 30:472-81. 2011
    ..Taken together, we found that CycT is an effective inhibitor of Hh signaling-mediated carcinogenesis...
  51. ncbi A long-latency aversive learning mechanism enables locusts to avoid odours associated with the consequences of ingesting toxic food
    Patrício M V Simões
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB1 3BU, UK
    J Exp Biol 215:1711-9. 2012
    ..Therefore, locusts can form specific long-lasting aversive olfactory associations that they can use to avoid toxin-containing foods whilst foraging...
  52. ncbi Induction of homochirality in achiral enantiomorphous monolayers
    Manfred Parschau
    Swiss Federal Laboratories for Materials Research EMPA, Molecular Surface Technologies 125, Uberlandstrasse 129, CH 8600 Dubendorf, Switzerland
    J Am Chem Soc 126:15398-9. 2004
    ..In analogy to the "sergeants-and-soldiers" principle described for helical polymers, this effect is explained by a lateral cooperative interaction within the two-dimensional lattice...
  53. ncbi Synergistic effect of salt mixture on the gelation temperature and morphology of methylcellulose hydrogel
    Mrinal Kanti Bain
    Department of Polymer Science and Technology, University of Calcutta, 92 A P C Road, Kolkata 700 009, India
    Int J Biol Macromol 51:831-6. 2012
    ..It was clear from ESEM images that when NaC and NaT were used separately the formation of network was not distinguishable. But, well-connected network structure was observed when a mixture 0.1 M NaC and 0.1 M NaT was used...
  54. ncbi Influence of the freezing method on the changes that occur in grape samples after frozen storage
    Luis G Santesteban
    Departamento de Producción Agraria, Universidad Publica de Navarra, 31006, Pamplona, Navarra, Spain
    J Sci Food Agric 93:3010-5. 2013
    ..However, freezing is usually performed using standard freezers, which provide a slow freezing. The aim of this work was to evaluate whether blast freezing would decrease the impact of standard freezing on grape composition...
  55. ncbi A chiral molecular conductor: synthesis, structure, and physical properties of [ET]3[Sb2(L-tart)2].CH3CN (ET = bis(ethylendithio)tetrathiafulvalene; L-tart = (2R,3R)-(+)-tartrate)
    Eugenio Coronado
    Instituto de Ciencia Molecular, Universidad de Valencia, C Doctor Moliner 50, 46100 Burjassot, Spain
    Inorg Chem 43:8072-7. 2004
    ..cm(-1) and semiconducting behavior with an activation energy of approximately 85 meV. Analysis of the magnetic susceptibility and band structure, however, suggests that this compound should be a narrow band gap semiconductor...
  56. ncbi 13C and 18O isotopic analysis to determine the origin of L-tartaric acid
    F Serra
    European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Physical and Chemical Exposure Unit, BEVABS, TP740, Italy
    Rapid Commun Mass Spectrom 19:1227-30. 2005
    ....
  57. ncbi The nature of the stimulus and of the fumarate binding site of the fumarate sensor DcuS of Escherichia coli
    Holger Kneuper
    Institut für Mikrobiologie und Weinforschung, Johannes Gutenberg Universitat Mainz, 55099 Mainz, Germany
    J Biol Chem 280:20596-603. 2005
    ..Therefore, the R147A mutation affected signal perception and transfer to the kinase but not the kinase activity per se...
  58. ncbi Enantiospecific total synthesis of (-)-bengamide E
    Prashant K Metri
    Department of Organic Chemistry, Indian Institute of Science, Sir C V Raman Av, Bangalore 560 012, India
    Chem Asian J 8:488-93. 2013
    ..Key reactions in the synthesis include desymmetrization of the bis(dimethylamide) unit of tartaric acid, Zn(BH(4))(2)-mediated anti-selective reduction, and a Horner-Wadsworth-Emmons olefination...
  59. ncbi An extensive investigation on nucleation, growth parameters, crystalline perfection, spectroscopy, thermal, optical, microhardness, dielectric and SHG studies on potential NLO crystal - ammonium Hydrogen L-tartarte
    Redrothu Hanumantharao
    School of Advanced Sciences, Vellore Institute of Technology University, Vellore, Tamilnadu 632 014, India
    Spectrochim Acta A Mol Biomol Spectrosc 103:388-99. 2013
    ..Fluorescence spectral studies were carried in the range of 280-500 nm for the grown crystal. The SHG conversion efficiency and laser damage threshold were measured using an Nd: YAG laser (1064 nm)...
  60. ncbi Reactive electrospinning and biodegradation of cross-linked methacrylated polycarbonate nanofibers
    Ruizhi Wu
    Department of Comprehensive Dentistry and Biomaterials, Louisiana State University Health Sciences Center, New Orleans, LA 70119, USA
    Biomed Mater 6:035004. 2011
    ....
  61. ncbi Application of partial least square on quantitative analysis of L-, D-, and DL-tartaric acid by terahertz absorption spectra
    Rika Nishikiori
    Faculty of Pharmaceutical Sciences, Osaka Ohtani University, 3 11 1 Nishikiori kita, Tondabayashi, Osaka 584 8540, Japan
    Chem Pharm Bull (Tokyo) 56:305-7. 2008
    ..Moreover, partial least square (PLS) can be found to improve the quantitation of L-tartaric acid in L- and DL-tartaric acid mixture by THz-TDS...
  62. ncbi Cyclization-induced turn-on fluorescence system applicable to dicarboxylate sensing
    Takao Noguchi
    Institute for Advanced Study, Kyushu University, 744 Moto oka, Nishi ku, Fukuoka 819 0395 Japan Nanotechnology Laboratory, Institute of Systems, Information Technologies and Nanotechnologies ISIT, 4 1 Kyudai Shinmachi, Nishi ku, Fukuoka 819 0388 Japan
    Chemistry 20:381-4. 2014
    ..This binding scheme achieves selective detection of dicarboxylates over monocarboxylates, thus is potentially applicable to the preliminary screening for metabolic disorders. ..
  63. ncbi Solution-phase chelators for suppressing nonspecific protein-metal interactions in electrospray mass spectrometry
    Jingxi Pan
    Department of Chemistry, The University of Western Ontario, London, Ontario, N6A 5B7, Canada
    Anal Chem 81:5008-15. 2009
    ..The use of tartrate and possibly other weak chelators will greatly enhance the reliability of future ESI-MS studies on the interactions of proteins with divalent metal ions...
  64. ncbi A list of organic kryptoracemates
    László Fábián
    Pfizer Institute for Pharmaceutical Materials Science, Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, England
    Acta Crystallogr B 66:94-103. 2010
    ..The centroid of a pair of enantiomers is more likely (99.9% versus 99% probability) to be located on an inversion center than is the centroid of a potentially centrosymmetric molecule...
  65. pmc Crystal structure of the narrow-spectrum OXA-46 class D beta-lactamase: relationship between active-site lysine carbamylation and inhibition by polycarboxylates
    Jean Denis Docquier
    Dipartimento di Biologia Molecolare, Universita di Siena, Siena, Italy
    Antimicrob Agents Chemother 54:2167-74. 2010
    ....
  66. ncbi Fluorescent coordination polymeric gel from tartaric acid-assisted self-assembly
    Sudip K Batabyal
    Department of Chemistry, National University of Singapore, Singapore 117543
    Langmuir 26:7464-8. 2010
    ..Such fluorescence enhancement is attributed to the reduction in nonradiative decay in the aggregated state. The organogel exhibits viscoelastic behavior as evidenced from the rheological studies...
  67. ncbi A practical and azide-free synthetic approach to oseltamivir from diethyl D-tartrate
    Jiang Weng
    Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, P R China 510006
    J Org Chem 75:3125-8. 2010
    ....
  68. ncbi Use of tert-butylbenzoylated tartardiamide chiral stationary phase for the enantiomeric resolution of acidic compounds by nano-liquid chromatography
    Salvatore Fanali
    Istituto di Metodologie Chimiche, C N R, Monterotondo Scalo Roma, Italy
    J Sep Sci 29:1423-31. 2006
    ..A decrease in resolution was observed with rising temperature, showing that enantioresolution was mainly influenced by selectivity factors...
  69. ncbi Brucine salts of L-alpha-hydroxy acids: brucinium hydrogen (S)-malate pentahydrate and anhydrous brucinium hydrogen (2R,3R)-tartrate at 130 K
    Graham Smith
    School of Physical and Chemical Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001, Australia
    Acta Crystallogr C 62:o353-7. 2006
    ..In compound (II), the brucinium cations form the common undulating brucine sheet substructures, which accommodate parallel chains of head-to-tail hydrogen-bonded tartrate anion species in the interstitial cavities...
  70. pmc Premixed calcium phosphate cements: synthesis, physical properties, and cell cytotoxicity
    Hockin H K Xu
    American Dental Association Foundation, Paffenbarger Research Center, 100 Bureau Drive Stop 8546, National Institute of Standards and Technology, Gaithersburg, MD 20899 8546, USA
    Dent Mater 23:433-41. 2007
    ..The objective of this study was to determine a formulation of premixed CPC (PCPC) with rapid setting, high strength, and good in vitro cell viability...
  71. ncbi Chemical composition and antidiabetic activity of Opuntia Milpa Alta extracts
    Chuan Luo
    Department of Medicinal Chemistry, Second Military Medical University, Shanghai, P R China
    Chem Biodivers 7:2869-79. 2010
    ..Taken together, the results indicate that the petroleum ether extract is the major hypoglycemic part in edible Opuntia Milpa Alta, which may be developed to a potential natural hypoglycemic functional ingredient...
  72. pmc The tobacco industry's past role in weight control related to smoking
    Semira Gonseth
    Department of Ambulatory Care and Community Medicine, Lausanne University Hospital, Switzerland
    Eur J Public Health 22:234-7. 2012
    ..We examined whether the tobacco industry played a role in appetite and body weight control related to smoking and smoking cessation...
  73. ncbi Enhancement of intestinal absorption of poorly absorbed hydrophilic compounds by simultaneous use of mucolytic agent and non-ionic surfactant
    Shinya Takatsuka
    Pharmaceutical Development Laboratories, Tanabe Seiyaku Co, Ltd, Osaka, Japan
    Eur J Pharm Biopharm 62:52-8. 2006
    ..All these results suggest that the combination of a mucolytic agent and a non-ionic surfactant may have potential as an enhancing system for peroral delivery of poorly absorbed hydrophilic compounds like protein and peptide drugs...
  74. ncbi X-ray studies of crystalline complexes involving amino acids and peptides. XLIV. Invariant features of supramolecular association and chiral effects in the complexes of arginine and lysine with tartaric acid
    M Selvaraj
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India
    Acta Crystallogr B 63:459-68. 2007
    ..The relevant crystal structures appear to indicate that the preference of L-lysine for D-tartaric acid is perhaps caused by chiral discrimination resulting from the amplification of a small energy difference...
  75. ncbi Continuous production of L(+)-tartaric acid from cis-epoxysuccinate using a membrane recycle reactor
    Ronnie Willaert
    Research Group of Industrial Microbiology, Fermentation Technology and Downstream Processing, Vrije Universiteit Brussel, Belgium
    Appl Microbiol Biotechnol 71:155-63. 2006
    ..The specific productivity could be nearly doubled when the number of reactors in the series was increased from 1 to 4...
  76. ncbi L-carnitine-L-tartrate promotes human hair growth in vitro
    Kerstin Foitzik
    Department of Dermatology, University Hospital Hamburg Eppendorf, University of Hamburg, Hamburg, Germany
    Exp Dermatol 16:936-45. 2007
    ..They further encourage one to explore topical and nutraceutical administration of l-carnitine as a well-tolerated, relatively safe adjuvant treatment in the management of androgenetic alopecia and other forms of hair loss...
  77. ncbi Molecular cloning of the type 5, iron-containing, tartrate-resistant acid phosphatase from human placenta
    C M Ketcham
    Department of Biochemistry and Molecular Biology, University of Florida, Gainesville 32610
    J Biol Chem 264:557-63. 1989
    ..Culture of K562 cells in presence of 10(-8) M phorbol 12-myristate 13-acetate ester for 48-72 h enhanced TR-AP activity per cell about 30-fold and led to a corresponding increase in TR-AP mRNA levels...
  78. ncbi Mice deficient in lysosomal acid phosphatase develop lysosomal storage in the kidney and central nervous system
    P Saftig
    Zentrum Biochemie und Molekulare Zellbiologie, Abteilung Biochemie II, Universitat Gottingen, Gosslerstrasse 12d, 37073 Gottingen, Federal Republic of Germany
    J Biol Chem 272:18628-35. 1997
    ..The causal relationship of the enzyme defect to the clinical manifestations remains to be determined...
  79. ncbi [Tartrate-sensitive and tartrate-resistant acid phosphatases in Amoeba proteus]
    V A Sopina
    Institute of Cytology RAS, St Petersburg
    Tsitologiia 42:602-12. 2000
    ..Therefore, tartrate-resistant AcP in A. proteus may be a lysosomal enzyme, while tartrate-resistant AcP may correspond to serine/threonine protein phosphatase...
  80. pmc Discrimination of d-tartrate-fermenting and -nonfermenting Salmonella enterica subsp. enterica isolates by genotypic and phenotypic methods
    Burkhard Malorny
    Federal Institute for Risk Assessment, National Salmonella Reference Laboratory, D 12277 Berlin, Germany
    J Clin Microbiol 41:4292-7. 2003
    ..Consequently, the PCR d-tartrate assay should be the method of choice for the discrimination of d-tartrate-fermenting and -nonfermenting Salmonella strains in the future...
  81. ncbi Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors
    Jun Ichi Karasawa
    Drug Discovery Institute, Nihon Schering K K, 1900 1 Togo, Mobara, Chiba 297 0017, Japan
    Pharmacol Biochem Behav 73:505-10. 2002
    ..These findings showed that MS-377 potentiates the efficacy of D(2) antagonists, but it does not deteriorate the adverse effect. Moreover, sigma(1) receptors are involved in this potentiation of the efficacy of D(2) antagonists by MS-377...
  82. ncbi Dicaffeoyltartaric acid analogues inhibit human immunodeficiency virus type 1 (HIV-1) integrase and HIV-1 replication at nontoxic concentrations
    Ryan A Reinke
    Department of Microbiology and Molecular Genetics, Pathology, and Medicine, University of California, Irvine, California 92697, USA
    J Med Chem 45:3669-83. 2002
    ....
  83. ncbi Effects of organic acids on copper and cadmium desorption from contaminated soils
    Yanzheng Gao
    College of Environment and Resources, Zhejiang University, 310028 Hangzhou, China
    Environ Int 29:613-8. 2003
    ..Based on these observations, we suggest that bioavailabilities of heavy metal can be promoted with selected suitable types and concentrations of organic acid amendment and reasonable field condition...
  84. ncbi Removal of Cu and Pb by tartaric acid modified rice husk from aqueous solutions
    K K Wong
    Faculty of Science and Environmental Studies, Department of Chemistry, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Chemosphere 50:23-8. 2003
    ..Metal uptake was reduced in the presence of competitive cations and chelators. The affinity of TARH for Pb is greater than Cu...
  85. ncbi Secreted phosphatase activity induced by dimethyl sulfoxide in Herpetomonas samuelpessoai
    Andre L S Santos
    Instituto de Microbiologia Prof Paulo de Goes, CCS, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Ilha do Fundao, RJ 21941 590, Rio de Janeiro, Brazil
    Arch Biochem Biophys 405:191-8. 2002
    ..We also demonstrate that DMSO induced the secretion and/or shedding of this phosphatase to the extracellular medium, with a possible involvement of protein kinase C in this process...
  86. pmc The glycosylphosphatidylinositol-anchored phosphatase from Spirodela oligorrhiza is a purple acid phosphatase
    H Nakazato
    Laboratory of Environmental Molecular Biology, Graduate School of Environmental Earth Science, Hokkaido University, Kita ku, Sapporo 060 0810, Japan
    Plant Physiol 118:1015-20. 1998
    ..These results, together with previous findings, strongly indicate that the GPI-anchored phosphatase of S. oligorrhiza is a PAP...
  87. ncbi [Simultaneous determination of 11 organic acids in fruit juice by ion exclusion chromatography]
    D H Guo
    Shanghai Entry-Exit Inspection and Quarantine Bureau of the People's Republic of China, Shanghai 200135, China
    Se Pu 19:276-8. 2001
    ..The precision of the method was investigated and the relative standard deviations were from 1.5% to 9.8% (n = 10)...
  88. ncbi Effects of meluadrine tartrate on maternal metabolic responses and fetal hemodynamics in pregnant goats
    Yoshio Matsuda
    Department of Obstetrics and Gynecology, Tokyo Women s Medical University, Tokyo, Japan
    Jpn J Pharmacol 90:114-20. 2002
    ..The present study suggests that meluadrine tartrate has a mild influence relative to the effects of ritodrine to the maternal metabolic responses and fetal cardiovascular function...
  89. ncbi Determination of the side-products formed during the nitroxide-mediated bleach oxidation of glucose to glucaric acid
    Mathias Ibert
    UMR 1064 IRCOF INSA de Rouen, BP08, F 76131 Mont Saint Aignan Cédex, France
    Carbohydr Res 337:1059-63. 2002
    ..The origin of all degradation products is rationalized. This study details a fast screening method to optimize the reaction conditions toward minimal degradation...
  90. ncbi Acylated anthocyanins from the blue-violet flowers of Anemone coronaria
    Norio Saito
    Chemical Laboratory, Meiji Gakuin University, Totsuka, Yokohama, Japan
    Phytochemistry 60:365-73. 2002
    ....
  91. ncbi Crystal structure of PMM/PGM: an enzyme in the biosynthetic pathway of P. aeruginosa virulence factors
    Catherine Regni
    Department of Biochemistry, 117 Schweitzer Hall, University of Missouri Columbia, Columbia, MO 65211, USA
    Structure 10:269-79. 2002
    ..aeruginosa infections...
  92. ncbi A novel NAD-binding protein revealed by the crystal structure of 2,3-diketo-L-gulonate reductase (YiaK)
    Farhad Forouhar
    Department of Biological Sciences, Northeast Structural Genomics Consortium, Columbia University, New York, NY 10027, USA
    J Biol Chem 279:13148-55. 2004
    ..The free enzyme conformation is incompatible with NAD binding. His(44) is likely the catalytic residue of the enzyme...
  93. ncbi Inhibition by sigma receptor ligand, MS-377, of N-methyl- D-aspartate-induced currents in dopamine neurons of the rat ventral tegmental area
    Yuu Yamazaki
    Department of Pharmacology, Hiroshima University School of Medicine, 1 2 3 Kasumi, Minami Ku, 734 8551, Japan
    Psychopharmacology (Berl) 161:64-9. 2002
    ....
  94. ncbi Cloning, sequence, and developmental expression of a type 5, tartrate-resistant, acid phosphatase of rat bone
    B Ek-Rylander
    Department of Oral Pathology, Karolinska Institute, School of Dentistry, Huddinge, Sweden
    J Biol Chem 266:24684-9. 1991
    ....
  95. ncbi Purification and characterization of an acid phosphatase from the commercial mushroom Agaricus bisporus
    W J Wannet
    Department of Microbiology, Faculty of Science, University of Nijmegen, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
    Antonie Van Leeuwenhoek 77:215-22. 2000
    ..Only phosphomonoesters were dephosphorylated. Antibodies raised against the purified enzyme could precipitate AP activity from a cell-free extract in an anticatalytic immunoprecipitation test...
  96. ncbi Synthesis of new chiral amines with a cyclic 1,2-diacetal skeleton derived from (2R, 3R)-(+)-tartaric acid
    M Teresa Barros
    Departamento de Química e Centro de Química Fina e Biotecnologia, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Monte de Caparica, 2829 516 Caparica, Portugal
    Molecules 11:177-96. 2006
    ....
  97. ncbi Hydrogen bonding in (2R,3R)-(+)-2,3-dimethoxybutanedioic acid [(+)-tartaric acid dimethyl ether]
    R E Gerkin
    Department of Chemistry, Ohio State University, Columbus 43210, USA
    Acta Crystallogr C 55:209-11. 1999
    ..OA distance is 2.665 (2) A. Each molecule is linked to four others by hydrogen bonds and to two others by C-H...O interactions. The dihedral angle between intramolecular carboxyl-group planes is 85.2 (1) degree...
  98. ncbi Stereoselective alkylation of tartrate derivatives. A concise route to (+)-O-methylpiscidic acid and natural analogues
    Anthony J Burke
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Oeiras, Portugal
    Org Biomol Chem 4:2361-3. 2006
    ..The alkylation products obtained possessed a cis stereochemistry, which was confirmed by the synthesis of natural 4'-O-methylpiscidic acid dimethyl ester ...
  99. ncbi Cocrystallization and amorphization induced by drug-excipient interaction improves the physical properties of acyclovir
    Takaaki Masuda
    R and D Laboratories, Pola Pharma Inc, 560 Kashio cho, Totsuka ku, Yokohama, Kanagawa 244 0812, Japan
    Int J Pharm 422:160-9. 2012
    ..We successfully improved the physical properties of acyclovir by the cocrystallization and amorphization techniques, using pharmaceutical excipients...
  100. ncbi Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric acid and water-soluble polymers monitored by NMR and solubility studies
    Laura Ribeiro
    Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000 295 Coimbra, Portugal
    Eur J Pharm Sci 24:1-13. 2005
    ....
  101. pmc Life-threatening hyperkalemia from cream of tartar ingestion
    Daniel E Rusyniak
    Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Med Toxicol 9:79-81. 2013
    ..We report two cases in which intentional ingestions of cream of tartar resulted in life-threatening hyperkalemia. In addition, we briefly review the use of cream of tartar as a historical purgative...

Research Grants12

  1. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005
    ..Laulimalide stimulates tubulin polymerization more effectively than paclitaxel. Laulimalide is a representative of a new class of microtubule stabilizing agents with promise for therapeutic potential. ..
  2. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
    ..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
  3. REDUCED DRUG INTERACTIONS OF AZOLE ANTIFUNGAL DRUGS
    Joseph Gal; Fiscal Year: 2003
    ..abstract_text> ..
  4. Synthesis of Novel Anticancer Agents
    MARISA KOZLOWSKI; Fiscal Year: 2007
    ..Routes to symmetric and dissymmetric chiral binaphthyl, perylenequinone, bisnaphthopyrone, bisanthraquinone, hypericin, and bisflavone natural products are presented. ..
  5. STRUCTURE OF VIRAL RNA AND ITS ROLE IN ASSEMBLY
    Alexander McPherson; Fiscal Year: 2006
    ..This research is significant because the conformation of the nucleic acid component of no virus is currently known, nor is there any comprehensive structural basis for the processes of viral assembly and disassembly. ..
  6. Designing Asymmetric Ligands Using Computational Techniques
    MARISA KOZLOWSKI; Fiscal Year: 2009
    ..The current proposal will create or retain four jobs. ..
  7. Preparing high resolution membrane protein crystals
    Zygmunt Derewenda; Fiscal Year: 2005
    ..abstract_text> ..
  8. Rapid protein crystallization by surface mutagenesis
    Zygmunt Derewenda; Fiscal Year: 2004
    ..Funds are requested to further test the general applicability and success rate of this method, and to apply the method to a subset of targets selected for the Structural Genomic Initiative. ..
  9. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  10. Novel Amino Acid-Based Glass-Ionomer Biomaterials
    Dong Xie; Fiscal Year: 2005
    ..abstract_text> ..
  11. Novel Nanostructured Dental Glass-Ionomers for Advanced Dental Restoratives
    Dong Xie; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Study of the Strength of CH-Y (Y =O,N)and XH-pi (X=N,O,S) Interactions
    BENJAMIN GUNG; Fiscal Year: 2006
    ..The understanding of these weak interactions is essential for rational drug design and lead optimization. [unreadable] [unreadable]..