Summary: A derivative of STARCH used as a plasma substitute in the treatment of hemorrhage.
Publications242 found, 100 shown here
- Effects of PentaLyte and Voluven hemodilution on plasma coagulation kinetics in the rabbit: role of thrombin-fibrinogen and factor XIII-fibrin polymer interactionsV G Nielsen
Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
Acta Anaesthesiol Scand 49:1263-71. 2005..I proposed to determine the hemostatic effect of hemodilution with PentaLyte (6% HES, mean molecular weight 220 kDa) and Voluven (6% HES, 130 kDa)...
- A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: safety not adequately addressedChristiane S Hartog
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
Anesth Analg 112:635-45. 2011..4 resuscitation are sufficiently well designed to draw conclusions about the safety of this compound. In addition, we wanted to assess crystalloid-to-colloid fluid ratios in studies with goal-directed fluid regimen...
- Hydroxyethyl starches: different products--different effectsMartin Westphal
Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
Anesthesiology 111:187-202. 2009..The impact of source material on structure and pharmacokinetics is highlighted, and the role of the carrier solution is critically assessed...
- Worsening of hepatic dysfunction as a consequence of repeated hydroxyethylstarch infusionsC Christidis
Department of Hepatogastroenterology, Jean Verdier Hospital, Bondy, France
J Hepatol 35:726-32. 2001..The basis of these adverse effects is the lysosomal storage of HES in Kupffer cells and hepatocytes...
- Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysisDavid J Gattas
Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
Anesth Analg 114:159-69. 2012..4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy...
- Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trialAlexey A Schramko
Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
Anesth Analg 108:30-6. 2009..Because the risk of bleeding is increased after cardiopulmonary bypass, we examined whether these types of HES solutions could be administered after cardiac surgery without an alteration of coagulation...
- Effect of volume loading with 1 liter intravenous infusions of 0.9% saline, 4% succinylated gelatine (Gelofusine) and 6% hydroxyethyl starch (Voluven) on blood volume and endocrine responses: a randomized, three-way crossover study in healthy volunteersDileep N Lobo
Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham, UK
Crit Care Med 38:464-70. 2010..9% saline, Gelofusine (4% succinylated gelatin in 0.7% saline, weight-average molecular weight 30 kD), and Voluven (6% hydroxyethyl starch in 0.9% saline, weight-average molecular weight 130 kD) in healthy volunteers...
- A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgeryR C Gallandat Huet
Department of Anesthesiology, University Hospital Groningen, The Netherlands
Can J Anaesth 47:1207-15. 2000..To compare the new hydroxyethyl starch HES 130/0.4 (Voluven) and the standard HES 200/0.5 (pentastarch) regarding effectiveness for plasma volume substitution and safety of large volumes in heart surgery...
- Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomyM Rehm
, , Klinikum Grosshadern, Munich, Germany
Anesthesiology 95:849-56. 2001..by infusing approximately 20 ml/kg of colloid at a rate of 90 ml/min (group I: 5% albumin solution; group II: 6% hetastarch solution; n = 10 each)...
- Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac functionDaniel A Reuter
Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
Crit Care Med 31:1399-404. 2003..The aim of this study was to investigate the ability of monitoring stroke volume variation to predict volume responsiveness and to assess changes in preload in patients with reduced left ventricular function after cardiac surgery...
- Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemiaRonald J Trof
Department of Intensive Care, Medical Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands
Intensive Care Med 36:697-701. 2010..The haemodynamics of crystalloid and colloid fluid loading may depend on underlying disease, i.e. sepsis versus non-sepsis...
- Osmotic nephrosis: acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutesMichael Dickenmann
Clinic for Transplantation Immunology and Nephrology, University Hospital, Basel, Switzerland
Am J Kidney Dis 51:491-503. 2008..It has a broad clinical spectrum that includes acute kidney injury and chronic kidney failure in rare cases. This article discusses the pathological characteristics, pathogenesis, and various clinical entities of osmotic nephrosis...
- Hydrops lysosomalis generalisatus--an underestimated side effect of hydroxyethyl starch therapy?Martin Schmidt-Hieber
Medizinische Klinik III Hämatologie, Onkologie und Transfusionsmedizin, Charite Campus Benjamin Franklin, Berlin, Germany
Eur J Haematol 77:83-5. 2006..We found severe infiltration of foamy cell degenerated macrophages in both organ systems, indicating that sequelae of HES therapy have to be included in the differential diagnosis of bone marrow and liver dysfunction...
- Human albumin and starch administration in critically ill patients: a prospective randomized clinical trialThiemo F Veneman
Department of Internal Medicine, Twenteborg Hospital, Almelo, The Netherlands
Wien Klin Wochenschr 116:305-9. 2004..e. lower mortality and fewer complications, compared to fluid replacement with normal saline...
- Effects of albumin 5% and artificial colloids on clot formation in small infantsT Haas
Department of Anaesthesiology and Intensive Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Anaesthesia 62:1000-7. 2007..From a haemostatic point of view it might be preferable to use gelatine solution as an alternative to albumin; HES showed the greatest effects on the overall coagulation process...
- The effect of the combined administration of colloids and lactated Ringer's solution on the coagulation system: an in vitro study using thrombelastograph coagulation analysis (ROTEGDietmar Fries
Department of Anesthesia and Intensive Care Medicine, The Leopold Franzens University of Innsbruck, Austria
Anesth Analg 94:1280-7, table of contents. 2002..We conclude that gelatin combined with 6% HES 200/0.5 or 6% HES 130/0.4 decreases hemostasis <6% HES 200/0.5 or 6% HES 130/0.4 administered alone...
- Effects on coagulation of balanced (130/0.42) and non-balanced (130/0.4) hydroxyethyl starch or gelatin compared with balanced Ringer's solution: an in vitro study using two different viscoelastic coagulation tests ROTEMTM and SONOCLOTTMM Casutt
Institute of Anesthesiology and Intensive Care, Kantonsspital Lucerne, Lucerne, Switzerland
Br J Anaesth 105:273-81. 2010..42 solution (HES(BAL)), a saline-based 6% HES 130/0.4 solution (HES(SAL)), a balanced lactated Ringer's solution (RL) and a saline-based 4% gelatin solution (GEL)...
- Effect of molecular weight and substitution on tissue uptake of hydroxyethyl starch: a meta-analysis of clinical studiesRomuald Bellmann
Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria
Clin Pharmacokinet 51:225-36. 2012..HES solutions of lower molecular weight and substitution have been developed to increase urinary excretion and reduce plasma persistence. However, their effect on tissue uptake of HES has not been investigated in human subjects...
- The effects of hydroxyethyl starch solution in critically ill patientsD Palumbo
Department of Surgical, Anesthesiological Intensive Care and Emergency Sciences, Federico II University of Naples, Naples, Italy
Minerva Anestesiol 72:655-64. 2006..In this study we have evaluated the effects of volume replacement, carried out with 2 different solutions: hydroxyethyl starch 6% (HAES) and albumin 20% (HA)...
- Assessing fluid responsiveness during open chest conditionsD A Reuter
Department of Anaesthesiology, University of Munich, 81377 Munich, Germany
Br J Anaesth 94:318-23. 2005..The aim of this study was to investigate the ability of SVV and PPV measured by arterial pulse contour analysis to assess fluid responsiveness in patients undergoing coronary artery bypass surgery during open-chest conditions...
- Hydroxyethyl starch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemiaJohannes N Hoffmann
Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Anesthesiology 97:460-70. 2002....
- Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgeryJoanne Verheij
Department of Intensive Care, VU Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
Intensive Care Med 32:1030-8. 2006..To study the effects on volume expansion and myocardial function of colloids or crystalloids in the treatment of hypovolaemic hypotension after cardiac and major vascular surgery...
- In vitro effects of different medium molecular hydroxyethyl starch solutions and lactated Ringer's solution on coagulation using SONOCLOTC J Konrad
Department of Anesthesiology and Intensive Care, Ruprecht Karls University of Heidelberg, Faculty of Clinical Medicine Mannheim, Germany
Anesth Analg 90:274-9. 2000..000 seems preferable regarding some aspects of clot formation and retraction. RL affected clot formation only minimally, except for the early activation of clotting, which was measured by a shortened activated clotting time...
- Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparisonOle Bayer
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
Crit Care Med 39:1335-42. 2011..4 and gelatin are considered to be less harmful. We hypothesized that fluid therapy with only crystalloids would decrease the incidence of acute kidney injury...
- Comparison of the acute hemodynamic effects of hypertonic or colloid infusions immediately after mitral valve repairD Sirieix
Department of Anesthesiology, Broussais Hospital, Paris, France
Crit Care Med 27:2159-65. 1999..To determine the acute hemodynamic effect of hypertonic saline and/or colloid solutions as volume resuscitation in postoperative mitral valve repair patients...
- CONTRA: Hydroxyethyl starch solutions are unsafe in critically ill patientsChristiane Hartog
Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
Intensive Care Med 35:1337-42. 2009..To describe the risk-benefit profile of hydroxyethyl starch (HES)...
- The impact of crystalloid and colloid infusion on the kidney in rodent sepsisMartin Alexander Schick
Klinik und Poliklinik für Anästhesiologie, Zentrum für Operative Medizin, University of Wurzburg, Oberdürrbacherstrasse 6, 97080 Wurzburg, Germany
Intensive Care Med 36:541-8. 2010..We therefore determined the impact of crystalloid and colloid solutions on kidney function in a rodent model of abdominal sepsis induced by cecal ligation and puncture (CLP)...
- Initial resuscitation with plasma and other blood components reduced bleeding compared to hetastarch in anesthetized swine with uncontrolled splenic hemorrhageJill L Sondeen
US Army Institute of Surgical Research, Fort Sam, Houston, Texas 78234 6315, USA
Transfusion 51:779-92. 2011..The purpose of this study was to evaluate resuscitation with either blood components or conventional fluids on coagulation and blood loss...
- Influence of a long-term, high-dose volume therapy with 6% hydroxyethyl starch 130/0.4 or crystalloid solution on hemodynamics, rheology and hemostasis in patients with acute ischemic stroke. Results of a randomized, placebo-controlled, double-blind studyRalph Woessner
Department of Neurology, Westpfalz Klinikum, University City of Kaiserslautern, Kaiserslautern, Germany
Pathophysiol Haemost Thromb 33:121-6. 2003..4 versus crystalloid solution, with particular regard to systemic and cerebral hemodynamics, rheology and safety...
- Less impairment of hemostasis and reduced blood loss in pigs after resuscitation from hemorrhagic shock using the small-volume concept with hypertonic saline/hydroxyethyl starch as compared to administration of 4% gelatin or 6% hydroxyethyl starch solutioThorsten Haas
Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Anesth Analg 106:1078-86, table of contents. 2008..All i.v. fluids cause dose-related dilutional coagulopathy and show intrinsic effects on the hemostatic system, but only few data refer to functional consequences after small-volume resuscitation...
- Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgeryH Berkenstadt
Department of Anesthesiology and Intensive Care, The Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
Anesth Analg 92:984-9. 2001..729, 95% CI: 0.645 to 0.813, P: = 4.3 x 10(-3)). An SVV value of 9.5% or more, will predict an increase in the SV of at least 5% in response to a 100-mL volume load, with a sensitivity of 79% and a specificity of 93%...
- Human neutrophil activation and increased adhesion by various resuscitation fluidsP Rhee
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Crit Care Med 28:74-8. 2000..We hypothesized that human neutrophil activation and adhesion vary, depending on the type and amount of resuscitation fluid used...
- Fibrinogen concentrate reverses dilutional coagulopathy induced in vitro by saline but not by hydroxyethyl starch 6%Claudia De Lorenzo
Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
Anesth Analg 102:1194-200. 2006..In contrast, HES molecules interfere with fibrin polymerization and, thus, administration of fibrinogen after dilution with HES 6% failed to significantly improve clot firmness...
- Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery: a randomised controlled pilot study (ISRCTN 11799696)J Harten
Department of Anaesthesia, Gartnavel General Hospital, Glasgow G12 0YN, UK
Int J Surg 6:197-204. 2008..The aim of the present pilot study was to examine the effect of goal directed therapy using fluid alone on postoperative renal function and organ failure score in patients undergoing emergency abdominal surgery...
- Infusion of albumin attenuates changes in serum protein binding of drugs in surgical patients compared with volume replacement with HAESP A Reine
Department of Anaesthesia, Medical Faculty, University of Oslo, Norway
Acta Anaesthesiol Scand 52:406-12. 2008..In vitro studies have indicated that stabilizers present in pharmaceutical-grade albumin influence albumin-binding capacity for highly protein bound drugs...
- Influence of low-molecular-weight hydroxyethyl starch on microvascular permeability in patients undergoing abdominal surgery: comparison with crystalloidYuko Ando
Department of Anesthesia, Nagasaki Rosai Hospital, 2 12 5 Setogoe, Sasebo, Nagasaki, 857 0134, Japan
J Anesth 22:391-6. 2008..This study was carried out to evaluate the effect of low-molecular-weight HES on the urinary microalbumin/creatinine ratio (MACR), a marker of microvascular permeability, in surgical patients...
- Protective roles of hydroxyethyl starch 130/0.4 in intestinal inflammatory response and oxidative stress after hemorrhagic shock and resuscitation in ratsPengfei Wang
Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210002, China
Inflammation 32:71-82. 2009..These physiological protective effects appear to be mediated by down-regulation of the transcription factor NF-kappaB and AP-1...
- The effect of Hetastarch (670/0.75) in vivo on platelet closure time in the dogLisa Smart
William R Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA
J Vet Emerg Crit Care (San Antonio) 19:444-9. 2009..To evaluate the effect of 6% hydroxyethyl starch (HES) solution in vivo, with an average molecular weight of 670 kDa and degree of substitution of 0.75, on canine platelet function...
- Hydroxyethyl starch for hypervolemic hemodilution in patients with acute ischemic stroke: a randomized, placebo-controlled phase II safety studyJ Rudolf
Klinik fur Neurologie der Universitat zu Koln, Koln, Deutschland
Cerebrovasc Dis 14:33-41. 2002..The objective of this study was to investigate the safety of a 10% solution of HES 130/0.4 versus 0.9% saline solution in acute ischemic stroke by the incidence of adverse events (AEs)...
- [Hydroxyethyl starch to protect renal function in laparoscopic surgery]J L Jover
Servicio de Anestesia, Hospital Verge dels Lliris, Alcoy, Alicante
Rev Esp Anestesiol Reanim 56:27-30. 2009..To evaluate the effect of prehydration with hydroxyethyl starch 130/0.4 (Voluven) compared to lactated Ringer solution in laparoscopic cholecystectomy...
- Hetastarch co-loading is as effective as pre-loading for the prevention of hypotension following spinal anesthesia for cesarean deliveryB Carvalho
Department of Anesthesiology, Stanford University School of Medicine, Stanford, California 94305, USA
Int J Obstet Anesth 18:150-5. 2009Pre-loading with hetastarch decreases the incidence and severity of hypotension after spinal anesthesia for cesarean delivery...
- Fluid management for laparoscopic colectomy: a prospective, randomized assessment of goal-directed administration of balanced salt solution or hetastarch coupled with an enhanced recovery programA J Senagore
Spectrum Health, Grand Rapids, Michigan, USA
Dis Colon Rectum 52:1935-40. 2009..the first assessment of standard, goal-directed perioperative fluid management with either lactated Ringer's or hetastarch/lactated Ringer's, with use of esophageal Doppler for guidance, in laparoscopic colectomy with an enhanced ..
- Changes in acid-base, electrolyte and hemoglobin concentrations during infusion of hydroxyethyl starch 130/0.42/6 : 1 in normal saline or in balanced electrolyte solution in childrenRobert Sumpelmann
Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin OE 8050, Hanover, Germany
Paediatr Anaesth 20:100-4. 2010..42/6 : 1 in normal saline (ns-HES) and in balanced electrolyte solution (bal-HES) was evaluated in children with a focus on acid-base, electrolyte and hemoglobin changes...
- Transfusion of autologous, hydroxyethyl starch-cryopreserved red blood cellsE P Horn
Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
Anesth Analg 85:739-45. 1997..Intravascular volume replacement and skeletal muscle oxygenation characteristics by erythrocytes did not differ between liquid-stored and cryopreserved RBC...
- Validity of pulse pressure and systolic blood pressure variation data obtained from a Datex Ohmeda S/5 monitor for predicting fluid responsiveness during surgeryHui Qiao
Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China
J Neurosurg Anesthesiol 22:316-22. 2010..A previously described method using the Datex Ohmeda S/5 monitor to record arterial and pulse pressure might be accurate enough to use for this purpose...
- The effects of colloid solutions on renal proximal tubular cells in vitroWinfried Neuhaus
Department of Anaesthesia and Critical Care, University Hospital Wurzburg, Wurzburg, Germany
Anesth Analg 114:371-4. 2012..HES130/0.4 exhibited the most distinctive harmful impact, whereas the application of crystalloid Sterofundin ISO revealed cytoprotective effects...
- First report on safety and efficacy of hetastarch solution for initial fluid resuscitation at a level 1 trauma centerMichael P Ogilvie
Daughtry Family Department of Surgery, Divisions of Trauma and Surgical Critical Care, University of Miami Miller School of Medicine, Miami, FL, USA
J Am Coll Surg 210:870-80, 880-2. 2010For logistics, the US Army recommends Hextend (Hospira; 6% hetastarch in buffered electrolyte, HET) for battlefield resuscitation. To support this practice, there are laboratory data, but none in humans...
- Effects of the novel 6% hydroxyethyl starch 130/0.4 on renal function of recipients in living-related kidney transplantationYan Wu
Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Chin Med J (Engl) 123:3079-83. 2010..4) and 4% succinylated gelatine, as donor kidney procurement, ischemia time and surgical conditions are comparable. Stroke volume variation (SVV) was used to monitor intravascular volume to avoid renal allograft hypoperfusion...
- Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problemsA Stolzing
Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany
Transfus Apher Sci 46:137-47. 2012..However, we suggest that the most common admixture ratio of HES and DMSO in cryoprotectant solutions has been established by historical happenstance and requires further investigation and optimization...
- Effect of hydroxyethyl starch on vascular leak syndrome and neutrophil accumulation during hypoxiaHans Jürgen Dieterich
Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
Crit Care Med 34:1775-82. 2006..Therefore, we compared functional influences of hydroxyethyl starch on normoxic or posthypoxic endothelia...
- Effect of hydroxyethyl starch 130/0.4 on blood loss and coagulation in patients with recent exposure to dual antiplatelet therapy undergoing off-pump coronary artery bypass graft surgeryJeong Soo Lee
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Japan
Circ J 75:2397-402. 2011..The aim of the present study was to determine whether a moderate dose of 6% HES 130/0.4 significantly increases perioperative blood loss in patients with continued DAPT within 5 days of OPCAB...
- Effect of albumin and Hespan on rodent hepatocyte function after hemorrhagic shock and sepsisAngie L Vlahos
Department of Surgery, Wayne State University, Detroit, Michigan, USA
J Trauma 59:583-8. 2005..This study assesses the effects of increased colloid osmotic pressure on albumin and urea genesis from hepatocytes exposed to HS or septic insult before harvesting...
- Haemodynamics and acid-base equilibrium after cardiac surgery: comparison of rapidly degradable hydroxyethyl starch solutions and albuminT Niemi
Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
Scand J Surg 97:259-65. 2008..We conducted a prospective, randomized, open-label study comparing haemodynamics and acid-base equilibrium after infusion of two rapidly degradable hydroxyethyl starch (HES) solutions or human albumin (HA) to cardiac surgical patients...
- Bioequivalence comparison between hydroxyethyl starch 130/0.42/6 : 1 and hydroxyethyl starch 130/0.4/9 : 1G Lehmann
Department of Anaesthesiology and Intensive Care Medicine, Rhoen Hospital Bad Berka, Kapellendorf, Germany
Drugs R D 8:229-40. 2007..42/6 : 1), altered in molar substitution and C2/C6 ratio, is bioequivalent to the former standard HES preparation (130/0.4/9 : 1)...
- A simple cryopreservation method for dendritic cells and cells used in their derivation and functional assessmentChristina M Celluzzi
Blood and Cell Therapy Development, American Red Cross Biomedical Research and Development, Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
Transfusion 43:488-94. 2003..HES and DMSO, used successfully in simple clinical procedures for freezing marrow and peripheral blood progenitor cells at -80 degrees C, was tested on antigen-presenting dendritic cells (DCs) and cells used in their derivation...
- It's the colloid, not the esophageal Doppler monitorPeter E Horowitz
Anesthesiology 99:238-9; author reply 239. 2003
- A randomized phase III clinical trial of autologous blood stem cell transplantation comparing cryopreservation using dimethylsulfoxide vs dimethylsulfoxide with hydroxyethylstarchS D Rowley
Clinical Research Division, Fred Hutchinson Cancer Research Center Seattle, WA, USA
Bone Marrow Transplant 31:1043-51. 2003..04). In contrast, median times to recovery of platelet count >or=20 x 10(9)/l were equivalent for each group (10 days; P=0.99) and the median numbers of red cell and platelet transfusions did not differ...
- Hydroxyethyl starch resuscitation reduces the risk of intra-abdominal hypertension in severe acute pancreatitisXiao Jiong Du
Department of Hepatobiliopancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
Pancreas 40:1220-5. 2011..This study aimed to address whether hydroxyethyl starch (HES) is beneficial for intra-abdominal pressure (IAP) in severe acute pancreatitis (SAP) in early stages...
- The effects of high molecular weight hydroxyethyl starch solutions on plateletsEngelbert Deusch
Department of Anesthesiology and Intensive Care B, Vienna Medical University, Waehringer Guertel 18 20, 1090 Vienna, Austria
Anesth Analg 99:665-8, table of contents. 2004..Citrated whole blood was hemodiluted in vitro (0% and 20%) with either HES 550 (Hextend), HES 600 (6%Hetastarch-Baxter), HES 200 (Elohäst), or the solvent of Hextend in its commercially available solution...
- Hydroxyethyl starch 130/0.4 augments healing of colonic anastomosis in a rat model of peritonitisPengfei Wang
Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, 305 E Zhongshan Rd, Nanjing, 210, 002, China
Am J Surg 199:232-9. 2010..This study was designed to investigate the role of hydroxyethyl starch (HES) 130/0.4 on the wound healing process in left colonic anastomoses in the presence of intra-abdominal sepsis...
- Differential storage of hydroxyethyl starch (HES) in the skin: an immunoelectron-microscopical long-term studyS Ständer
Department of Dermatology, University of Munster, Germany
Cell Tissue Res 304:261-9. 2001..The condensation and final dissolution of the vacuoles may either indicate the release and subsequent redistribution of HES into the circulation or lysosomal degradation...
- Global end-diastolic volume as an indicator of cardiac preload in patients with septic shockFrederic Michard
Medical Intensive Care Unit, Bicetre Hospital, University Paris XI, France
Chest 124:1900-8. 2003..To assess the value of the global end-diastolic volume (GEDV) evaluated by transpulmonary thermodilution as an indicator of cardiac preload...
- Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsisG Marx
University of Liverpool, University Department of Anaesthesia, Liverpool, UK
Eur J Anaesthesiol 21:132-8. 2004..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
- Repetitive large-dose infusion of the novel hydroxyethyl starch 130/0.4 in patients with severe head injuryThomas A Neff
Institute of Anesthesiology, University Hospital, Zurich, Switzerland
Anesth Analg 96:1453-9, table of contents. 2003..4 group despite the large HES doses administered. We conclude that HES 130/0.4 can safely be used in critically ill head trauma patients over several days at doses of up to 70 mL x kg(-1) x d(-1)...
- The effects of hydroxyethyl starches of varying molecular weights on platelet functionA Franz
Department of Anesthesiology and Intensive Care B, University of Vienna, School of Medicine, Vienna, Austria
Anesth Analg 92:1402-7. 2001..Our data indicate that fluid resuscitation with HES 130/0.38--0.45 may reduce the risk of bleeding associated with synthetic colloids of higher molecular weight and degree of substitution...
- Safety of HES 130/0.4 (Voluven(R)) in patients with preoperative renal dysfunction undergoing abdominal aortic surgery: a prospective, randomized, controlled, parallel-group multicentre trialG Godet
Universite Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, Centre Hospitalo Universitaire Pitie Salpetriere, Department of Anesthesiology and Critical Care, Paris, France
Eur J Anaesthesiol 25:986-94. 2008..This study investigated the safety profile of a recent medium-molecular-weight hydroxyethyl starch (HES) preparation with a low molar substitution (HES 130/0.4) in this sensitive patient group...
- An international view of hydroxyethyl starchesJ Treib
Department of Neurology, University Hospital of the Saarland, Homburg, Germany
Intensive Care Med 25:258-68. 1999..Because of increasing international competition and the availability of newly developed starches, it is important to be aware of the pharmacological properties of HES and the advantages and disadvantages of the individual preparations...
- Hextend, a physiologically balanced plasma expander for large volume use in major surgery: a randomized phase III clinical trial. Hextend Study GroupT J Gan
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesth Analg 88:992-8. 1999Hextend (BioTime, Inc., Berkeley, CA) is a new plasma volume expander containing 6% hetastarch, balanced electrolytes, a lactate buffer, and physiological levels of glucose...
- Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shockGernot Marx
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
Crit Care Med 34:3005-10. 2006..Recently, a new HES with a low molecular weight (130 kD) and lower molar substitution (0.42) has been developed. In this study, we compared effects of HES 130/0.42 and HES 200/0.5 on capillary leakage in porcine septic shock...
- Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challengeDavid Osman
Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, Universite Paris XI, Le Kremlin Bicetre, France
Crit Care Med 35:64-8. 2007..By analyzing a large number of volume challenges, our aim was to test the significance of the recommended target values in terms of prediction of volume responsiveness...
- The impact of a medium molecular weight, low molar substitution hydroxyethyl starch dissolved in a physiologically balanced electrolyte solution on blood coagulation and platelet function in vitroJ Boldt
Clinic of Anaesthesiology and Intensive Care Medicine, Academic City Hospital, Bremserstrasse 79, D 67063 Ludwigshafen, Germany
Vox Sang 93:139-44. 2007..42; B-HES) with a commercially available non-balanced HES (MW 130, MS 0.4; NB-HES), and with Ringer's lactate (RL) solution in vitro...
- 3.5% urea-linked gelatin is as effective as 6% HES 200/0.5 for volume management in cardiac surgery patientsPhilippe J Van der Linden
Department of Cardiac Anesthesia, CHU Charleroi, Charleroi, Belgium
Can J Anaesth 51:236-41. 2004..5% gelatin and 6% hydroxyethyl starch 200/0.5 in patients undergoing cardiac surgery. The second objective was to compare the two colloids in terms of blood losses and allogeneic blood transfusion exposure rate...
- Albumin versus hydroxyethyl starch in cardiopulmonary bypass surgery: a meta-analysis of postoperative bleedingM M Wilkes
Hygeia Associates, Grass Valley, California 95949, USA
Ann Thorac Surg 72:527-33; discussion 534. 2001..This meta-analysis tested the hypothesis that cumulative blood loss during the first 24 hours after cardiopulmonary bypass is lower in patients exposed to albumin than hydroxyethyl starch (HES)...
- Voluven, a lower substituted novel hydroxyethyl starch (HES 130/0.4), causes fewer effects on coagulation in major orthopedic surgery than HES 200/0.5O Langeron
, , Paris, France
Anesth Analg 92:855-62. 2001....
- Profound effects of cardiopulmonary bypass priming solutions on the fibrin part of clot formation: an ex vivo evaluation using rotation thromboelastometryArinda C M Brinkman
Department of Anesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
J Cardiothorac Vasc Anesth 24:422-6. 2010..Therefore, the authors investigated whether hemodilution with different priming solutions distinctly affects the fibrinogen-mediated step in whole blood clot formation...
- Insulin and pentastarch for severe sepsisDavid Bracco
N Engl J Med 358:2072; author reply 2074-5. 2008
- Hydroxyethyl starch-induced renal insufficiency after plasma exchange in a patient with polymyositis and liver cirrhosisS Peron
Department of Internal Medicine, HÄµpital Avicenne and Assistance Publique HÄµpitaux de Paris, France
Clin Nephrol 55:408-11. 2001..Renal insufficiency occurred with biopsy-proven osmotic nephrosis-like lesions, considered to be secondary to HES infusions and/or CyA...
- Effects of hydroxyethyl starch solutions on hemostasisSibylle A Kozek-Langenecker
Department of General Anesthesiology and Intensive Care B, Medical University of Vienna, Austria
Anesthesiology 103:654-60. 2005
- [The design of the VISEP trial. Critical appraisal]R Zander
Institut fur Physiologie und Pathophysiologie, Universitat Mainz
Anaesthesist 56:71-7. 2007..Thus, any further advance presentations and interpretations should be shelved in expectation of the authors' publication of all the data, in order to begin further discussions including the flaws in study design listed here...
- A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuationNora Philbin
Naval Medical Research Center, Combat Casualty Care, 2N77 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Resuscitation 66:367-78. 2005..To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation...
- Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expandersPedro Cabrales
La Jolla Bioengineering Institute, La Jolla, California 92037, USA
Shock 24:66-73. 2005..Furthermore, PEG-Alb appears to provide early and long-term sustained systemic and microvascular recovery when used to restitute perfusion and metabolic conditions after resuscitation from hemorrhagic shock...
- Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemiaDavid R McIlroy
Department of Anesthesiology, University of Washington Medical Center, Seattle, USA
Anesth Analg 96:1572-7, table of contents. 2003..in intravascular volume achieved with 1000 mL of lactated Ringer's solution compared with the same volume of 6% Hetastarch. Subjects were made moderately hypovolemic by the withdrawal of 900 mL of blood, and then the crystalloid or ..
- The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patientsN J Wilkes
Centre for Anaesthesia, Royal Free and University College Medical School, London, United Kingdom
Anesth Analg 93:811-6. 2001..the Balanced Fluid group received an intraoperative fluid regimen that consisted of Hartmann's solution and 6% hetastarch in balanced electrolyte and glucose injection (Hextend). Patients in the Saline group were given 0...
- A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluidsAnthony M Roche
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesth Analg 102:1274-9. 2006..Saline and lactated Ringer's solution produced a hypercoagulable state at 20%-40% dilutions. Saline, hetastarch in saline, pentastarch in saline, tetrastarch in saline, and human albumin solutions all produced a ..
- Effects of hydroxyethyl starch administration on renal function in critically ill patientsY Sakr
Friedrich Schiller University, Jena, Germany
Br J Anaesth 98:216-24. 2007..We investigated the effect of HES administration on renal function in critically ill patients enrolled in a large multicentre observational European study...
- A new plasma-adapted hydroxyethylstarch preparation: in vitro coagulation studies using thrombelastography and whole blood aggregometryJoachim Boldt
Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany
Anesth Analg 104:425-30. 2007..In a blinded in vitro study, we compared the effects on hemostasis of a new HES, prepared in a balanced solution, with a conventional HES preparation and Ringer's lactate solution...
- Comparison of the effects of gelatin and a modern hydroxyethyl starch solution on renal function and inflammatory response in elderly cardiac surgery patientsJ Boldt
Department of Anaesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr 79, D 67063 Ludwigshafen, Germany
Br J Anaesth 100:457-64. 2008..The effects of hydroxyethylstarch (HES) 130/0.4 6% and gelatin 4% on inflammation, endothelial integrity, and renal function after cardiac surgery were compared...
- Acquired lysosomal storage caused by frequent plasmapheresis procedures with hydroxyethyl starchJohannes J A Auwerda
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Transfusion 46:1705-11. 2006..In case of massive tissue storage, this enzyme activity can reach levels comparable to those of Gaucher disease...
- Hemodilution modulates the time of onset and rate of fibrinolysis in human and rabbit plasmaVance G Nielsen
Division of Cardiothoracic Anesthesia, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
J Heart Lung Transplant 25:1344-52. 2006..However, chronically, VAD-mediated fibrinolysis may also diminish thromboembolic events. Management of VADs involves fluid administration. It was hypothesized that the fluid administered could modulate fibrinolysis...
- Renal histopathological lesions after orthotopic liver transplantation (OLT)Evangeline Pillebout
Hopital Saint Louis, Nephrology and Kidney Transplantation, Paris, France
Am J Transplant 5:1120-9. 2005..These investigations have therapeutic potential, that is, they may lead to a more aggressive treatment of hypertension and/or diabetes...
- Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleedingPedro Cabrales
La Jolla Bioengineering Institute, La Jolla, California 92093 0412, USA
Shock 23:549-55. 2005..These findings suggest the possibility of using hyperviscous plasma expanders to prolong the period for initial treatment of blood losses and definitive institution therapy...
- Thrombelastographic whole blood clot formation after ex vivo addition of plasma substitutes: improvements of the induced coagulopathy with fibrinogen concentrateC Fenger-Eriksen
Department of Anaesthesiology, Aarhus University Hospital, Aarhus Sygehus, Denmark
Br J Anaesth 94:324-9. 2005..Whilst several mechanisms have been advanced to explain the nature of the coagulopathy induced by this colloid, there has been comparably little interest in devising ways to optimize haemostasis after a relative colloid overdose...
- HES 130/0.42 shows less alteration of pharmacokinetics than HES 200/0.5 when dosed repeatedlyG B Lehmann
Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
Br J Anaesth 98:635-44. 2007..HES 130/0.42 with low molecular weight and a low level of substitution has recently been developed in order to reduce those risks...
- Osmotic nephrosis in a renal transplant recipientZ Ebcioglu
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Kidney Int 70:1873-6. 2006
- Intensive insulin therapy and pentastarch resuscitation in severe sepsisFrank M Brunkhorst
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
N Engl J Med 358:125-39. 2008..The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids...
- Effects of Hextend hemodilution on plasma coagulation kinetics in the rabbit: role of factor XIII-mediated fibrin polymer crosslinkingVance G Nielsen
Department of Anesthesiology, University of Alabama at Birmingham, 619 South 19th Street, 35249 6810, USA
J Surg Res 132:17-22. 2006..Thus, the purpose of the present study was to determine the effect of in vivo hemodilution with Hextend (6% hydroxyethyl starch, mean molecular weight 450 kDa) on plasma coagulation kinetics...
- Fluid resuscitation in severe sepsis and septic shock: albumin, hydroxyethyl starch, gelatin or ringer's lactate-does it really make a difference?Fuhong Su
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
Shock 27:520-6. 2007..v. fluid did not affect outcome...
- Comparison of the novel hydroxyethylstarch 130/0.4 and hydroxyethylstarch 200/0.6 in brain-dead donor resuscitation on renal function after transplantationV Blasco
Département d anesthésie et de réanimation, CHU Nord, Assistance Publique Hopitaux de Marseille, 13915 Marseille Cedex 20, France
Br J Anaesth 100:504-8. 2008..4 or HES 200/0.6) used for the resuscitation of brain-dead donors on the rate of delayed graft function (DGF) and the serum creatinine levels post-transplantation...
- Initial administration of hydroxyethyl starch vs lactated Ringer after liver trauma in the pigM Zaar
Department of Anaesthesia, Faculty of Health Sciences, University of Copenhagen, Denmark
Br J Anaesth 102:221-6. 2009..This study tested the circulatory effectiveness of post-trauma administration of a large intravascular volume expander, hydroxyethyl starch 130/0.4 (HES), vs standard lactated Ringer's solution (RL)...
- Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion modelLars Hüter
Department of Anaesthesiology and Intensive Care Medicine, University of Jena, Erlanger Allee, Jena, Germany
Crit Care 13:R23. 2009..The aim of the study was to evaluate some of the underlying pathomechanisms of hydroxyethylstarch (HES) induced adverse effects on renal function using 24 porcine kidneys in an isolated perfusion model over six hours...
- Phase III Study Comparing Albumin and Hetastarch Therapy in Acute Lung InjuryGregory S Martin; Fiscal Year: 2013..This trial will also provide requisite data for any subsequent clinical trials targeted at other clinically relevant outcomes, such as mortality, the duration of mechanical ventilation, or health-related quality of life. ..
- PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORTLELAND CLARK; Fiscal Year: 1992..This research should provide new means of measuring and regulating tissue oxygen tensions and tissue oxygen availability in heart attack, stroke, cancer chemotherapy, and trauma...
- MECHANISMS AND PREVENTION OF HEMOGLOBIN NEUROTOXICITYSAMUEL PANTER; Fiscal Year: 2002..These studies will delineate a hemoglobin-dependent contribution to neural injury following opening of the blood-brain barrier and will test several therapeutic candidates that could be used in the clinical setting of CABG surgery. ..
- Induced hypothermic arrest in traumatic shockHasan Alam; Fiscal Year: 2005..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
- Bioengineering Methods to Study Blood SubstitutesAnthony Cheung; Fiscal Year: 2004..abstract_text> ..
- HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLSSteven Deem; Fiscal Year: 2002....
- Red Blood Cells, Nitric Oxide and Pulmonary CirculationSteven Deem; Fiscal Year: 2008..abstract_text> ..
- Neural and non-neural modulators of skin blood flow and sweating in humansCRAIG CRANDALL; Fiscal Year: 2009..e. diabetes, heart failure, etc) and non-disease (i.e. aging) conditions. ..
- Skin Cooling to Improve Orthostatic ToleranceCRAIG CRANDALL; Fiscal Year: 2005....
- Patient-Oriented Cancer Research Training ProgramEmil Freireich; Fiscal Year: 2004..The program will prepare oncology physician specialists for careers in academic patient-oriented research in oncology. ..
- Biochemical Stabilization for Freeze Dried PlateletsChristopher Wagner; Fiscal Year: 2003..abstract_text> ..
- Imaging Flow CytometerAlbert Donnenberg; Fiscal Year: 2006..Should this proposal be funded, we are very well positioned to play a leading role in applying this new technology to cancer, immunology, and cell biology research. [unreadable] [unreadable]..
- Oxygen Carriers for Hypovolemic Circulatory CollapseRobert Winslow; Fiscal Year: 2007..The research described in this proposal will focus on molecules and formulations specifically tailored for use in prehospital and trauma settings. ..