hetastarch

Summary

Summary: A derivative of STARCH used as a plasma substitute in the treatment of hemorrhage.

Top Publications

  1. ncbi Effects of PentaLyte and Voluven hemodilution on plasma coagulation kinetics in the rabbit: role of thrombin-fibrinogen and factor XIII-fibrin polymer interactions
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Acta Anaesthesiol Scand 49:1263-71. 2005
  2. ncbi A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: safety not adequately addressed
    Christiane S Hartog
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Anesth Analg 112:635-45. 2011
  3. ncbi Hydroxyethyl starches: different products--different effects
    Martin Westphal
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Anesthesiology 111:187-202. 2009
  4. ncbi Worsening of hepatic dysfunction as a consequence of repeated hydroxyethylstarch infusions
    C Christidis
    Department of Hepatogastroenterology, Jean Verdier Hospital, Bondy, France
    J Hepatol 35:726-32. 2001
  5. ncbi Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis
    David J Gattas
    Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
    Anesth Analg 114:159-69. 2012
  6. ncbi Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial
    Alexey A Schramko
    Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
    Anesth Analg 108:30-6. 2009
  7. ncbi Effect of volume loading with 1 liter intravenous infusions of 0.9% saline, 4% succinylated gelatine (Gelofusine) and 6% hydroxyethyl starch (Voluven) on blood volume and endocrine responses: a randomized, three-way crossover study in healthy volunteers
    Dileep N Lobo
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham, UK
    Crit Care Med 38:464-70. 2010
  8. ncbi A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery
    R C Gallandat Huet
    Department of Anesthesiology, University Hospital Groningen, The Netherlands
    Can J Anaesth 47:1207-15. 2000
  9. ncbi Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy
    M Rehm
    , , Klinikum Grosshadern, Munich, Germany
    Anesthesiology 95:849-56. 2001
  10. ncbi Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac function
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
    Crit Care Med 31:1399-404. 2003

Detail Information

Publications242 found, 100 shown here

  1. ncbi Effects of PentaLyte and Voluven hemodilution on plasma coagulation kinetics in the rabbit: role of thrombin-fibrinogen and factor XIII-fibrin polymer interactions
    V G Nielsen
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35249 6810, USA
    Acta Anaesthesiol Scand 49:1263-71. 2005
    ..I proposed to determine the hemostatic effect of hemodilution with PentaLyte (6% HES, mean molecular weight 220 kDa) and Voluven (6% HES, 130 kDa)...
  2. ncbi A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: safety not adequately addressed
    Christiane S Hartog
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Anesth Analg 112:635-45. 2011
    ..4 resuscitation are sufficiently well designed to draw conclusions about the safety of this compound. In addition, we wanted to assess crystalloid-to-colloid fluid ratios in studies with goal-directed fluid regimen...
  3. ncbi Hydroxyethyl starches: different products--different effects
    Martin Westphal
    Department of Anesthesiology and Intensive Care, University Hospital of Muenster, Muenster, Germany
    Anesthesiology 111:187-202. 2009
    ..The impact of source material on structure and pharmacokinetics is highlighted, and the role of the carrier solution is critically assessed...
  4. ncbi Worsening of hepatic dysfunction as a consequence of repeated hydroxyethylstarch infusions
    C Christidis
    Department of Hepatogastroenterology, Jean Verdier Hospital, Bondy, France
    J Hepatol 35:726-32. 2001
    ..The basis of these adverse effects is the lysosomal storage of HES in Kupffer cells and hepatocytes...
  5. ncbi Fluid resuscitation with 6% hydroxyethyl starch (130/0.4) in acutely ill patients: an updated systematic review and meta-analysis
    David J Gattas
    Critical Care and Trauma Division, The George Institute for Global Health, University of Sydney, Australia
    Anesth Analg 114:159-69. 2012
    ..4 is one of the most frequently used resuscitation fluids worldwide. The retraction of studies evaluating its use necessitates a reevaluation of available evidence regarding its safety and efficacy...
  6. ncbi Rapidly degradable hydroxyethyl starch solutions impair blood coagulation after cardiac surgery: a prospective randomized trial
    Alexey A Schramko
    Department of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
    Anesth Analg 108:30-6. 2009
    ..Because the risk of bleeding is increased after cardiopulmonary bypass, we examined whether these types of HES solutions could be administered after cardiac surgery without an alteration of coagulation...
  7. ncbi Effect of volume loading with 1 liter intravenous infusions of 0.9% saline, 4% succinylated gelatine (Gelofusine) and 6% hydroxyethyl starch (Voluven) on blood volume and endocrine responses: a randomized, three-way crossover study in healthy volunteers
    Dileep N Lobo
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham, UK
    Crit Care Med 38:464-70. 2010
    ..9% saline, Gelofusine (4% succinylated gelatin in 0.7% saline, weight-average molecular weight 30 kD), and Voluven (6% hydroxyethyl starch in 0.9% saline, weight-average molecular weight 130 kD) in healthy volunteers...
  8. ncbi A novel hydroxyethyl starch (Voluven) for effective perioperative plasma volume substitution in cardiac surgery
    R C Gallandat Huet
    Department of Anesthesiology, University Hospital Groningen, The Netherlands
    Can J Anaesth 47:1207-15. 2000
    ..To compare the new hydroxyethyl starch HES 130/0.4 (Voluven) and the standard HES 200/0.5 (pentastarch) regarding effectiveness for plasma volume substitution and safety of large volumes in heart surgery...
  9. ncbi Changes in blood volume and hematocrit during acute preoperative volume loading with 5% albumin or 6% hetastarch solutions in patients before radical hysterectomy
    M Rehm
    , , Klinikum Grosshadern, Munich, Germany
    Anesthesiology 95:849-56. 2001
    ..by infusing approximately 20 ml/kg of colloid at a rate of 90 ml/min (group I: 5% albumin solution; group II: 6% hetastarch solution; n = 10 each)...
  10. ncbi Usefulness of left ventricular stroke volume variation to assess fluid responsiveness in patients with reduced cardiac function
    Daniel A Reuter
    Department of Anesthesiology, University of Munich, Grosshadern University Hospital, Germany
    Crit Care Med 31:1399-404. 2003
    ..The aim of this study was to investigate the ability of monitoring stroke volume variation to predict volume responsiveness and to assess changes in preload in patients with reduced left ventricular function after cardiac surgery...
  11. pmc Greater cardiac response of colloid than saline fluid loading in septic and non-septic critically ill patients with clinical hypovolaemia
    Ronald J Trof
    Department of Intensive Care, Medical Spectrum Twente, Haaksbergerstraat 55, 7513 ER, Enschede, The Netherlands
    Intensive Care Med 36:697-701. 2010
    ..The haemodynamics of crystalloid and colloid fluid loading may depend on underlying disease, i.e. sepsis versus non-sepsis...
  12. ncbi Osmotic nephrosis: acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes
    Michael Dickenmann
    Clinic for Transplantation Immunology and Nephrology, University Hospital, Basel, Switzerland
    Am J Kidney Dis 51:491-503. 2008
    ..It has a broad clinical spectrum that includes acute kidney injury and chronic kidney failure in rare cases. This article discusses the pathological characteristics, pathogenesis, and various clinical entities of osmotic nephrosis...
  13. ncbi Hydrops lysosomalis generalisatus--an underestimated side effect of hydroxyethyl starch therapy?
    Martin Schmidt-Hieber
    Medizinische Klinik III Hämatologie, Onkologie und Transfusionsmedizin, Charite Campus Benjamin Franklin, Berlin, Germany
    Eur J Haematol 77:83-5. 2006
    ..We found severe infiltration of foamy cell degenerated macrophages in both organ systems, indicating that sequelae of HES therapy have to be included in the differential diagnosis of bone marrow and liver dysfunction...
  14. ncbi Human albumin and starch administration in critically ill patients: a prospective randomized clinical trial
    Thiemo F Veneman
    Department of Internal Medicine, Twenteborg Hospital, Almelo, The Netherlands
    Wien Klin Wochenschr 116:305-9. 2004
    ..e. lower mortality and fewer complications, compared to fluid replacement with normal saline...
  15. ncbi Effects of albumin 5% and artificial colloids on clot formation in small infants
    T Haas
    Department of Anaesthesiology and Intensive Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anaesthesia 62:1000-7. 2007
    ..From a haemostatic point of view it might be preferable to use gelatine solution as an alternative to albumin; HES showed the greatest effects on the overall coagulation process...
  16. ncbi The effect of the combined administration of colloids and lactated Ringer's solution on the coagulation system: an in vitro study using thrombelastograph coagulation analysis (ROTEG
    Dietmar Fries
    Department of Anesthesia and Intensive Care Medicine, The Leopold Franzens University of Innsbruck, Austria
    Anesth Analg 94:1280-7, table of contents. 2002
    ..We conclude that gelatin combined with 6% HES 200/0.5 or 6% HES 130/0.4 decreases hemostasis <6% HES 200/0.5 or 6% HES 130/0.4 administered alone...
  17. ncbi Effects on coagulation of balanced (130/0.42) and non-balanced (130/0.4) hydroxyethyl starch or gelatin compared with balanced Ringer's solution: an in vitro study using two different viscoelastic coagulation tests ROTEMTM and SONOCLOTTM
    M Casutt
    Institute of Anesthesiology and Intensive Care, Kantonsspital Lucerne, Lucerne, Switzerland
    Br J Anaesth 105:273-81. 2010
    ..42 solution (HES(BAL)), a saline-based 6% HES 130/0.4 solution (HES(SAL)), a balanced lactated Ringer's solution (RL) and a saline-based 4% gelatin solution (GEL)...
  18. ncbi Effect of molecular weight and substitution on tissue uptake of hydroxyethyl starch: a meta-analysis of clinical studies
    Romuald Bellmann
    Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria
    Clin Pharmacokinet 51:225-36. 2012
    ..HES solutions of lower molecular weight and substitution have been developed to increase urinary excretion and reduce plasma persistence. However, their effect on tissue uptake of HES has not been investigated in human subjects...
  19. ncbi The effects of hydroxyethyl starch solution in critically ill patients
    D Palumbo
    Department of Surgical, Anesthesiological Intensive Care and Emergency Sciences, Federico II University of Naples, Naples, Italy
    Minerva Anestesiol 72:655-64. 2006
    ..In this study we have evaluated the effects of volume replacement, carried out with 2 different solutions: hydroxyethyl starch 6% (HAES) and albumin 20% (HA)...
  20. ncbi Assessing fluid responsiveness during open chest conditions
    D A Reuter
    Department of Anaesthesiology, University of Munich, 81377 Munich, Germany
    Br J Anaesth 94:318-23. 2005
    ..The aim of this study was to investigate the ability of SVV and PPV measured by arterial pulse contour analysis to assess fluid responsiveness in patients undergoing coronary artery bypass surgery during open-chest conditions...
  21. ncbi Hydroxyethyl starch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemia
    Johannes N Hoffmann
    Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Anesthesiology 97:460-70. 2002
    ....
  22. ncbi Cardiac response is greater for colloid than saline fluid loading after cardiac or vascular surgery
    Joanne Verheij
    Department of Intensive Care, VU Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Intensive Care Med 32:1030-8. 2006
    ..To study the effects on volume expansion and myocardial function of colloids or crystalloids in the treatment of hypovolaemic hypotension after cardiac and major vascular surgery...
  23. ncbi In vitro effects of different medium molecular hydroxyethyl starch solutions and lactated Ringer's solution on coagulation using SONOCLOT
    C J Konrad
    Department of Anesthesiology and Intensive Care, Ruprecht Karls University of Heidelberg, Faculty of Clinical Medicine Mannheim, Germany
    Anesth Analg 90:274-9. 2000
    ..000 seems preferable regarding some aspects of clot formation and retraction. RL affected clot formation only minimally, except for the early activation of clotting, which was measured by a shortened activated clotting time...
  24. ncbi Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison
    Ole Bayer
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
    Crit Care Med 39:1335-42. 2011
    ..4 and gelatin are considered to be less harmful. We hypothesized that fluid therapy with only crystalloids would decrease the incidence of acute kidney injury...
  25. ncbi Comparison of the acute hemodynamic effects of hypertonic or colloid infusions immediately after mitral valve repair
    D Sirieix
    Department of Anesthesiology, Broussais Hospital, Paris, France
    Crit Care Med 27:2159-65. 1999
    ..To determine the acute hemodynamic effect of hypertonic saline and/or colloid solutions as volume resuscitation in postoperative mitral valve repair patients...
  26. ncbi CONTRA: Hydroxyethyl starch solutions are unsafe in critically ill patients
    Christiane Hartog
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 35:1337-42. 2009
    ..To describe the risk-benefit profile of hydroxyethyl starch (HES)...
  27. ncbi The impact of crystalloid and colloid infusion on the kidney in rodent sepsis
    Martin Alexander Schick
    Klinik und Poliklinik für Anästhesiologie, Zentrum für Operative Medizin, University of Wurzburg, Oberdürrbacherstrasse 6, 97080 Wurzburg, Germany
    Intensive Care Med 36:541-8. 2010
    ..We therefore determined the impact of crystalloid and colloid solutions on kidney function in a rodent model of abdominal sepsis induced by cecal ligation and puncture (CLP)...
  28. ncbi Initial resuscitation with plasma and other blood components reduced bleeding compared to hetastarch in anesthetized swine with uncontrolled splenic hemorrhage
    Jill L Sondeen
    US Army Institute of Surgical Research, Fort Sam, Houston, Texas 78234 6315, USA
    Transfusion 51:779-92. 2011
    ..The purpose of this study was to evaluate resuscitation with either blood components or conventional fluids on coagulation and blood loss...
  29. ncbi Influence of a long-term, high-dose volume therapy with 6% hydroxyethyl starch 130/0.4 or crystalloid solution on hemodynamics, rheology and hemostasis in patients with acute ischemic stroke. Results of a randomized, placebo-controlled, double-blind study
    Ralph Woessner
    Department of Neurology, Westpfalz Klinikum, University City of Kaiserslautern, Kaiserslautern, Germany
    Pathophysiol Haemost Thromb 33:121-6. 2003
    ..4 versus crystalloid solution, with particular regard to systemic and cerebral hemodynamics, rheology and safety...
  30. ncbi Less impairment of hemostasis and reduced blood loss in pigs after resuscitation from hemorrhagic shock using the small-volume concept with hypertonic saline/hydroxyethyl starch as compared to administration of 4% gelatin or 6% hydroxyethyl starch solutio
    Thorsten Haas
    Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Anesth Analg 106:1078-86, table of contents. 2008
    ..All i.v. fluids cause dose-related dilutional coagulopathy and show intrinsic effects on the hemostatic system, but only few data refer to functional consequences after small-volume resuscitation...
  31. ncbi Stroke volume variation as a predictor of fluid responsiveness in patients undergoing brain surgery
    H Berkenstadt
    Department of Anesthesiology and Intensive Care, The Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Anesth Analg 92:984-9. 2001
    ..729, 95% CI: 0.645 to 0.813, P: = 4.3 x 10(-3)). An SVV value of 9.5% or more, will predict an increase in the SV of at least 5% in response to a 100-mL volume load, with a sensitivity of 79% and a specificity of 93%...
  32. ncbi Human neutrophil activation and increased adhesion by various resuscitation fluids
    P Rhee
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Crit Care Med 28:74-8. 2000
    ..We hypothesized that human neutrophil activation and adhesion vary, depending on the type and amount of resuscitation fluid used...
  33. ncbi Fibrinogen concentrate reverses dilutional coagulopathy induced in vitro by saline but not by hydroxyethyl starch 6%
    Claudia De Lorenzo
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    Anesth Analg 102:1194-200. 2006
    ..In contrast, HES molecules interfere with fibrin polymerization and, thus, administration of fibrinogen after dilution with HES 6% failed to significantly improve clot firmness...
  34. ncbi Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery: a randomised controlled pilot study (ISRCTN 11799696)
    J Harten
    Department of Anaesthesia, Gartnavel General Hospital, Glasgow G12 0YN, UK
    Int J Surg 6:197-204. 2008
    ..The aim of the present pilot study was to examine the effect of goal directed therapy using fluid alone on postoperative renal function and organ failure score in patients undergoing emergency abdominal surgery...
  35. ncbi Infusion of albumin attenuates changes in serum protein binding of drugs in surgical patients compared with volume replacement with HAES
    P A Reine
    Department of Anaesthesia, Medical Faculty, University of Oslo, Norway
    Acta Anaesthesiol Scand 52:406-12. 2008
    ..In vitro studies have indicated that stabilizers present in pharmaceutical-grade albumin influence albumin-binding capacity for highly protein bound drugs...
  36. ncbi Influence of low-molecular-weight hydroxyethyl starch on microvascular permeability in patients undergoing abdominal surgery: comparison with crystalloid
    Yuko Ando
    Department of Anesthesia, Nagasaki Rosai Hospital, 2 12 5 Setogoe, Sasebo, Nagasaki, 857 0134, Japan
    J Anesth 22:391-6. 2008
    ..This study was carried out to evaluate the effect of low-molecular-weight HES on the urinary microalbumin/creatinine ratio (MACR), a marker of microvascular permeability, in surgical patients...
  37. ncbi Protective roles of hydroxyethyl starch 130/0.4 in intestinal inflammatory response and oxidative stress after hemorrhagic shock and resuscitation in rats
    Pengfei Wang
    Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, 210002, China
    Inflammation 32:71-82. 2009
    ..These physiological protective effects appear to be mediated by down-regulation of the transcription factor NF-kappaB and AP-1...
  38. ncbi The effect of Hetastarch (670/0.75) in vivo on platelet closure time in the dog
    Lisa Smart
    William R Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA
    J Vet Emerg Crit Care (San Antonio) 19:444-9. 2009
    ..To evaluate the effect of 6% hydroxyethyl starch (HES) solution in vivo, with an average molecular weight of 670 kDa and degree of substitution of 0.75, on canine platelet function...
  39. ncbi Hydroxyethyl starch for hypervolemic hemodilution in patients with acute ischemic stroke: a randomized, placebo-controlled phase II safety study
    J Rudolf
    Klinik fur Neurologie der Universitat zu Koln, Koln, Deutschland
    Cerebrovasc Dis 14:33-41. 2002
    ..The objective of this study was to investigate the safety of a 10% solution of HES 130/0.4 versus 0.9% saline solution in acute ischemic stroke by the incidence of adverse events (AEs)...
  40. ncbi [Hydroxyethyl starch to protect renal function in laparoscopic surgery]
    J L Jover
    Servicio de Anestesia, Hospital Verge dels Lliris, Alcoy, Alicante
    Rev Esp Anestesiol Reanim 56:27-30. 2009
    ..To evaluate the effect of prehydration with hydroxyethyl starch 130/0.4 (Voluven) compared to lactated Ringer solution in laparoscopic cholecystectomy...
  41. ncbi Hetastarch co-loading is as effective as pre-loading for the prevention of hypotension following spinal anesthesia for cesarean delivery
    B Carvalho
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, California 94305, USA
    Int J Obstet Anesth 18:150-5. 2009
    Pre-loading with hetastarch decreases the incidence and severity of hypotension after spinal anesthesia for cesarean delivery...
  42. ncbi Fluid management for laparoscopic colectomy: a prospective, randomized assessment of goal-directed administration of balanced salt solution or hetastarch coupled with an enhanced recovery program
    A J Senagore
    Spectrum Health, Grand Rapids, Michigan, USA
    Dis Colon Rectum 52:1935-40. 2009
    ..the first assessment of standard, goal-directed perioperative fluid management with either lactated Ringer's or hetastarch/lactated Ringer's, with use of esophageal Doppler for guidance, in laparoscopic colectomy with an enhanced ..
  43. ncbi Changes in acid-base, electrolyte and hemoglobin concentrations during infusion of hydroxyethyl starch 130/0.42/6 : 1 in normal saline or in balanced electrolyte solution in children
    Robert Sumpelmann
    Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin OE 8050, Hanover, Germany
    Paediatr Anaesth 20:100-4. 2010
    ..42/6 : 1 in normal saline (ns-HES) and in balanced electrolyte solution (bal-HES) was evaluated in children with a focus on acid-base, electrolyte and hemoglobin changes...
  44. ncbi Transfusion of autologous, hydroxyethyl starch-cryopreserved red blood cells
    E P Horn
    Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany
    Anesth Analg 85:739-45. 1997
    ..Intravascular volume replacement and skeletal muscle oxygenation characteristics by erythrocytes did not differ between liquid-stored and cryopreserved RBC...
  45. ncbi Validity of pulse pressure and systolic blood pressure variation data obtained from a Datex Ohmeda S/5 monitor for predicting fluid responsiveness during surgery
    Hui Qiao
    Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China
    J Neurosurg Anesthesiol 22:316-22. 2010
    ..A previously described method using the Datex Ohmeda S/5 monitor to record arterial and pulse pressure might be accurate enough to use for this purpose...
  46. ncbi The effects of colloid solutions on renal proximal tubular cells in vitro
    Winfried Neuhaus
    Department of Anaesthesia and Critical Care, University Hospital Wurzburg, Wurzburg, Germany
    Anesth Analg 114:371-4. 2012
    ..HES130/0.4 exhibited the most distinctive harmful impact, whereas the application of crystalloid Sterofundin ISO revealed cytoprotective effects...
  47. ncbi First report on safety and efficacy of hetastarch solution for initial fluid resuscitation at a level 1 trauma center
    Michael P Ogilvie
    Daughtry Family Department of Surgery, Divisions of Trauma and Surgical Critical Care, University of Miami Miller School of Medicine, Miami, FL, USA
    J Am Coll Surg 210:870-80, 880-2. 2010
    For logistics, the US Army recommends Hextend (Hospira; 6% hetastarch in buffered electrolyte, HET) for battlefield resuscitation. To support this practice, there are laboratory data, but none in humans...
  48. ncbi Effects of the novel 6% hydroxyethyl starch 130/0.4 on renal function of recipients in living-related kidney transplantation
    Yan Wu
    Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    Chin Med J (Engl) 123:3079-83. 2010
    ..4) and 4% succinylated gelatine, as donor kidney procurement, ischemia time and surgical conditions are comparable. Stroke volume variation (SVV) was used to monitor intravascular volume to avoid renal allograft hypoperfusion...
  49. ncbi Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems
    A Stolzing
    Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany
    Transfus Apher Sci 46:137-47. 2012
    ..However, we suggest that the most common admixture ratio of HES and DMSO in cryoprotectant solutions has been established by historical happenstance and requires further investigation and optimization...
  50. ncbi Effect of hydroxyethyl starch on vascular leak syndrome and neutrophil accumulation during hypoxia
    Hans Jürgen Dieterich
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Tubingen, Germany
    Crit Care Med 34:1775-82. 2006
    ..Therefore, we compared functional influences of hydroxyethyl starch on normoxic or posthypoxic endothelia...
  51. ncbi Effect of hydroxyethyl starch 130/0.4 on blood loss and coagulation in patients with recent exposure to dual antiplatelet therapy undergoing off-pump coronary artery bypass graft surgery
    Jeong Soo Lee
    Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Japan
    Circ J 75:2397-402. 2011
    ..The aim of the present study was to determine whether a moderate dose of 6% HES 130/0.4 significantly increases perioperative blood loss in patients with continued DAPT within 5 days of OPCAB...
  52. ncbi Effect of albumin and Hespan on rodent hepatocyte function after hemorrhagic shock and sepsis
    Angie L Vlahos
    Department of Surgery, Wayne State University, Detroit, Michigan, USA
    J Trauma 59:583-8. 2005
    ..This study assesses the effects of increased colloid osmotic pressure on albumin and urea genesis from hepatocytes exposed to HS or septic insult before harvesting...
  53. ncbi Haemodynamics and acid-base equilibrium after cardiac surgery: comparison of rapidly degradable hydroxyethyl starch solutions and albumin
    T Niemi
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital, Meilahti Hospital, Helsinki, Finland
    Scand J Surg 97:259-65. 2008
    ..We conducted a prospective, randomized, open-label study comparing haemodynamics and acid-base equilibrium after infusion of two rapidly degradable hydroxyethyl starch (HES) solutions or human albumin (HA) to cardiac surgical patients...
  54. ncbi Bioequivalence comparison between hydroxyethyl starch 130/0.42/6 : 1 and hydroxyethyl starch 130/0.4/9 : 1
    G Lehmann
    Department of Anaesthesiology and Intensive Care Medicine, Rhoen Hospital Bad Berka, Kapellendorf, Germany
    Drugs R D 8:229-40. 2007
    ..42/6 : 1), altered in molar substitution and C2/C6 ratio, is bioequivalent to the former standard HES preparation (130/0.4/9 : 1)...
  55. ncbi A simple cryopreservation method for dendritic cells and cells used in their derivation and functional assessment
    Christina M Celluzzi
    Blood and Cell Therapy Development, American Red Cross Biomedical Research and Development, Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Transfusion 43:488-94. 2003
    ..HES and DMSO, used successfully in simple clinical procedures for freezing marrow and peripheral blood progenitor cells at -80 degrees C, was tested on antigen-presenting dendritic cells (DCs) and cells used in their derivation...
  56. ncbi It's the colloid, not the esophageal Doppler monitor
    Peter E Horowitz
    Anesthesiology 99:238-9; author reply 239. 2003
  57. ncbi A randomized phase III clinical trial of autologous blood stem cell transplantation comparing cryopreservation using dimethylsulfoxide vs dimethylsulfoxide with hydroxyethylstarch
    S D Rowley
    Clinical Research Division, Fred Hutchinson Cancer Research Center Seattle, WA, USA
    Bone Marrow Transplant 31:1043-51. 2003
    ..04). In contrast, median times to recovery of platelet count >or=20 x 10(9)/l were equivalent for each group (10 days; P=0.99) and the median numbers of red cell and platelet transfusions did not differ...
  58. ncbi Hydroxyethyl starch resuscitation reduces the risk of intra-abdominal hypertension in severe acute pancreatitis
    Xiao Jiong Du
    Department of Hepatobiliopancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
    Pancreas 40:1220-5. 2011
    ..This study aimed to address whether hydroxyethyl starch (HES) is beneficial for intra-abdominal pressure (IAP) in severe acute pancreatitis (SAP) in early stages...
  59. ncbi The effects of high molecular weight hydroxyethyl starch solutions on platelets
    Engelbert Deusch
    Department of Anesthesiology and Intensive Care B, Vienna Medical University, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Anesth Analg 99:665-8, table of contents. 2004
    ..Citrated whole blood was hemodiluted in vitro (0% and 20%) with either HES 550 (Hextend), HES 600 (6%Hetastarch-Baxter), HES 200 (Elohäst), or the solvent of Hextend in its commercially available solution...
  60. ncbi Hydroxyethyl starch 130/0.4 augments healing of colonic anastomosis in a rat model of peritonitis
    Pengfei Wang
    Research Institute of General Surgery, Jinling Hospital, Nanjing University School of Medicine, 305 E Zhongshan Rd, Nanjing, 210, 002, China
    Am J Surg 199:232-9. 2010
    ..This study was designed to investigate the role of hydroxyethyl starch (HES) 130/0.4 on the wound healing process in left colonic anastomoses in the presence of intra-abdominal sepsis...
  61. ncbi Differential storage of hydroxyethyl starch (HES) in the skin: an immunoelectron-microscopical long-term study
    S Ständer
    Department of Dermatology, University of Munster, Germany
    Cell Tissue Res 304:261-9. 2001
    ..The condensation and final dissolution of the vacuoles may either indicate the release and subsequent redistribution of HES into the circulation or lysosomal degradation...
  62. ncbi Global end-diastolic volume as an indicator of cardiac preload in patients with septic shock
    Frederic Michard
    Medical Intensive Care Unit, Bicetre Hospital, University Paris XI, France
    Chest 124:1900-8. 2003
    ..To assess the value of the global end-diastolic volume (GEDV) evaluated by transpulmonary thermodilution as an indicator of cardiac preload...
  63. ncbi Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis
    G Marx
    University of Liverpool, University Department of Anaesthesia, Liverpool, UK
    Eur J Anaesthesiol 21:132-8. 2004
    ..Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis...
  64. ncbi Repetitive large-dose infusion of the novel hydroxyethyl starch 130/0.4 in patients with severe head injury
    Thomas A Neff
    Institute of Anesthesiology, University Hospital, Zurich, Switzerland
    Anesth Analg 96:1453-9, table of contents. 2003
    ..4 group despite the large HES doses administered. We conclude that HES 130/0.4 can safely be used in critically ill head trauma patients over several days at doses of up to 70 mL x kg(-1) x d(-1)...
  65. ncbi The effects of hydroxyethyl starches of varying molecular weights on platelet function
    A Franz
    Department of Anesthesiology and Intensive Care B, University of Vienna, School of Medicine, Vienna, Austria
    Anesth Analg 92:1402-7. 2001
    ..Our data indicate that fluid resuscitation with HES 130/0.38--0.45 may reduce the risk of bleeding associated with synthetic colloids of higher molecular weight and degree of substitution...
  66. ncbi Safety of HES 130/0.4 (Voluven(R)) in patients with preoperative renal dysfunction undergoing abdominal aortic surgery: a prospective, randomized, controlled, parallel-group multicentre trial
    G Godet
    Universite Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, Centre Hospitalo Universitaire Pitie Salpetriere, Department of Anesthesiology and Critical Care, Paris, France
    Eur J Anaesthesiol 25:986-94. 2008
    ..This study investigated the safety profile of a recent medium-molecular-weight hydroxyethyl starch (HES) preparation with a low molar substitution (HES 130/0.4) in this sensitive patient group...
  67. ncbi An international view of hydroxyethyl starches
    J Treib
    Department of Neurology, University Hospital of the Saarland, Homburg, Germany
    Intensive Care Med 25:258-68. 1999
    ..Because of increasing international competition and the availability of newly developed starches, it is important to be aware of the pharmacological properties of HES and the advantages and disadvantages of the individual preparations...
  68. ncbi Hextend, a physiologically balanced plasma expander for large volume use in major surgery: a randomized phase III clinical trial. Hextend Study Group
    T J Gan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 88:992-8. 1999
    Hextend (BioTime, Inc., Berkeley, CA) is a new plasma volume expander containing 6% hetastarch, balanced electrolytes, a lactate buffer, and physiological levels of glucose...
  69. ncbi Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock
    Gernot Marx
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
    Crit Care Med 34:3005-10. 2006
    ..Recently, a new HES with a low molecular weight (130 kD) and lower molar substitution (0.42) has been developed. In this study, we compared effects of HES 130/0.42 and HES 200/0.5 on capillary leakage in porcine septic shock...
  70. ncbi Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challenge
    David Osman
    Service de Reanimation Medicale, Centre Hospitalo Universitaire de Bicêtre, Assistance Publique Hopitaux de Paris, Universite Paris XI, Le Kremlin Bicetre, France
    Crit Care Med 35:64-8. 2007
    ..By analyzing a large number of volume challenges, our aim was to test the significance of the recommended target values in terms of prediction of volume responsiveness...
  71. ncbi The impact of a medium molecular weight, low molar substitution hydroxyethyl starch dissolved in a physiologically balanced electrolyte solution on blood coagulation and platelet function in vitro
    J Boldt
    Clinic of Anaesthesiology and Intensive Care Medicine, Academic City Hospital, Bremserstrasse 79, D 67063 Ludwigshafen, Germany
    Vox Sang 93:139-44. 2007
    ..42; B-HES) with a commercially available non-balanced HES (MW 130, MS 0.4; NB-HES), and with Ringer's lactate (RL) solution in vitro...
  72. ncbi 3.5% urea-linked gelatin is as effective as 6% HES 200/0.5 for volume management in cardiac surgery patients
    Philippe J Van der Linden
    Department of Cardiac Anesthesia, CHU Charleroi, Charleroi, Belgium
    Can J Anaesth 51:236-41. 2004
    ..5% gelatin and 6% hydroxyethyl starch 200/0.5 in patients undergoing cardiac surgery. The second objective was to compare the two colloids in terms of blood losses and allogeneic blood transfusion exposure rate...
  73. ncbi Albumin versus hydroxyethyl starch in cardiopulmonary bypass surgery: a meta-analysis of postoperative bleeding
    M M Wilkes
    Hygeia Associates, Grass Valley, California 95949, USA
    Ann Thorac Surg 72:527-33; discussion 534. 2001
    ..This meta-analysis tested the hypothesis that cumulative blood loss during the first 24 hours after cardiopulmonary bypass is lower in patients exposed to albumin than hydroxyethyl starch (HES)...
  74. ncbi Voluven, a lower substituted novel hydroxyethyl starch (HES 130/0.4), causes fewer effects on coagulation in major orthopedic surgery than HES 200/0.5
    O Langeron
    , , Paris, France
    Anesth Analg 92:855-62. 2001
    ....
  75. ncbi Profound effects of cardiopulmonary bypass priming solutions on the fibrin part of clot formation: an ex vivo evaluation using rotation thromboelastometry
    Arinda C M Brinkman
    Department of Anesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiothorac Vasc Anesth 24:422-6. 2010
    ..Therefore, the authors investigated whether hemodilution with different priming solutions distinctly affects the fibrinogen-mediated step in whole blood clot formation...
  76. ncbi Insulin and pentastarch for severe sepsis
    David Bracco
    N Engl J Med 358:2072; author reply 2074-5. 2008
  77. ncbi Hydroxyethyl starch-induced renal insufficiency after plasma exchange in a patient with polymyositis and liver cirrhosis
    S Peron
    Department of Internal Medicine, Hĵpital Avicenne and Assistance Publique Hĵpitaux de Paris, France
    Clin Nephrol 55:408-11. 2001
    ..Renal insufficiency occurred with biopsy-proven osmotic nephrosis-like lesions, considered to be secondary to HES infusions and/or CyA...
  78. ncbi Effects of hydroxyethyl starch solutions on hemostasis
    Sibylle A Kozek-Langenecker
    Department of General Anesthesiology and Intensive Care B, Medical University of Vienna, Austria
    Anesthesiology 103:654-60. 2005
  79. ncbi [The design of the VISEP trial. Critical appraisal]
    R Zander
    Institut fur Physiologie und Pathophysiologie, Universitat Mainz
    Anaesthesist 56:71-7. 2007
    ..Thus, any further advance presentations and interpretations should be shelved in expectation of the authors' publication of all the data, in order to begin further discussions including the flaws in study design listed here...
  80. ncbi A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation
    Nora Philbin
    Naval Medical Research Center, Combat Casualty Care, 2N77 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Resuscitation 66:367-78. 2005
    ..To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation...
  81. ncbi Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92037, USA
    Shock 24:66-73. 2005
    ..Furthermore, PEG-Alb appears to provide early and long-term sustained systemic and microvascular recovery when used to restitute perfusion and metabolic conditions after resuscitation from hemorrhagic shock...
  82. ncbi Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia
    David R McIlroy
    Department of Anesthesiology, University of Washington Medical Center, Seattle, USA
    Anesth Analg 96:1572-7, table of contents. 2003
    ..in intravascular volume achieved with 1000 mL of lactated Ringer's solution compared with the same volume of 6% Hetastarch. Subjects were made moderately hypovolemic by the withdrawal of 900 mL of blood, and then the crystalloid or ..
  83. ncbi The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients
    N J Wilkes
    Centre for Anaesthesia, Royal Free and University College Medical School, London, United Kingdom
    Anesth Analg 93:811-6. 2001
    ..the Balanced Fluid group received an intraoperative fluid regimen that consisted of Hartmann's solution and 6% hetastarch in balanced electrolyte and glucose injection (Hextend). Patients in the Saline group were given 0...
  84. ncbi A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluids
    Anthony M Roche
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 102:1274-9. 2006
    ..Saline and lactated Ringer's solution produced a hypercoagulable state at 20%-40% dilutions. Saline, hetastarch in saline, pentastarch in saline, tetrastarch in saline, and human albumin solutions all produced a ..
  85. ncbi Effects of hydroxyethyl starch administration on renal function in critically ill patients
    Y Sakr
    Friedrich Schiller University, Jena, Germany
    Br J Anaesth 98:216-24. 2007
    ..We investigated the effect of HES administration on renal function in critically ill patients enrolled in a large multicentre observational European study...
  86. ncbi A new plasma-adapted hydroxyethylstarch preparation: in vitro coagulation studies using thrombelastography and whole blood aggregometry
    Joachim Boldt
    Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany
    Anesth Analg 104:425-30. 2007
    ..In a blinded in vitro study, we compared the effects on hemostasis of a new HES, prepared in a balanced solution, with a conventional HES preparation and Ringer's lactate solution...
  87. ncbi Comparison of the effects of gelatin and a modern hydroxyethyl starch solution on renal function and inflammatory response in elderly cardiac surgery patients
    J Boldt
    Department of Anaesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstr 79, D 67063 Ludwigshafen, Germany
    Br J Anaesth 100:457-64. 2008
    ..The effects of hydroxyethylstarch (HES) 130/0.4 6% and gelatin 4% on inflammation, endothelial integrity, and renal function after cardiac surgery were compared...
  88. ncbi Acquired lysosomal storage caused by frequent plasmapheresis procedures with hydroxyethyl starch
    Johannes J A Auwerda
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Transfusion 46:1705-11. 2006
    ..In case of massive tissue storage, this enzyme activity can reach levels comparable to those of Gaucher disease...
  89. ncbi Hemodilution modulates the time of onset and rate of fibrinolysis in human and rabbit plasma
    Vance G Nielsen
    Division of Cardiothoracic Anesthesia, Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35249 6810, USA
    J Heart Lung Transplant 25:1344-52. 2006
    ..However, chronically, VAD-mediated fibrinolysis may also diminish thromboembolic events. Management of VADs involves fluid administration. It was hypothesized that the fluid administered could modulate fibrinolysis...
  90. ncbi Renal histopathological lesions after orthotopic liver transplantation (OLT)
    Evangeline Pillebout
    Hopital Saint Louis, Nephrology and Kidney Transplantation, Paris, France
    Am J Transplant 5:1120-9. 2005
    ..These investigations have therapeutic potential, that is, they may lead to a more aggressive treatment of hypertension and/or diabetes...
  91. ncbi Increase plasma viscosity sustains microcirculation after resuscitation from hemorrhagic shock and continuous bleeding
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, California 92093 0412, USA
    Shock 23:549-55. 2005
    ..These findings suggest the possibility of using hyperviscous plasma expanders to prolong the period for initial treatment of blood losses and definitive institution therapy...
  92. ncbi Thrombelastographic whole blood clot formation after ex vivo addition of plasma substitutes: improvements of the induced coagulopathy with fibrinogen concentrate
    C Fenger-Eriksen
    Department of Anaesthesiology, Aarhus University Hospital, Aarhus Sygehus, Denmark
    Br J Anaesth 94:324-9. 2005
    ..Whilst several mechanisms have been advanced to explain the nature of the coagulopathy induced by this colloid, there has been comparably little interest in devising ways to optimize haemostasis after a relative colloid overdose...
  93. ncbi HES 130/0.42 shows less alteration of pharmacokinetics than HES 200/0.5 when dosed repeatedly
    G B Lehmann
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    Br J Anaesth 98:635-44. 2007
    ..HES 130/0.42 with low molecular weight and a low level of substitution has recently been developed in order to reduce those risks...
  94. ncbi Osmotic nephrosis in a renal transplant recipient
    Z Ebcioglu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Kidney Int 70:1873-6. 2006
  95. ncbi Intensive insulin therapy and pentastarch resuscitation in severe sepsis
    Frank M Brunkhorst
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    N Engl J Med 358:125-39. 2008
    ..The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids...
  96. ncbi Effects of Hextend hemodilution on plasma coagulation kinetics in the rabbit: role of factor XIII-mediated fibrin polymer crosslinking
    Vance G Nielsen
    Department of Anesthesiology, University of Alabama at Birmingham, 619 South 19th Street, 35249 6810, USA
    J Surg Res 132:17-22. 2006
    ..Thus, the purpose of the present study was to determine the effect of in vivo hemodilution with Hextend (6% hydroxyethyl starch, mean molecular weight 450 kDa) on plasma coagulation kinetics...
  97. ncbi Fluid resuscitation in severe sepsis and septic shock: albumin, hydroxyethyl starch, gelatin or ringer's lactate-does it really make a difference?
    Fuhong Su
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Brussels, Belgium
    Shock 27:520-6. 2007
    ..v. fluid did not affect outcome...
  98. ncbi Comparison of the novel hydroxyethylstarch 130/0.4 and hydroxyethylstarch 200/0.6 in brain-dead donor resuscitation on renal function after transplantation
    V Blasco
    Département d anesthésie et de réanimation, CHU Nord, Assistance Publique Hopitaux de Marseille, 13915 Marseille Cedex 20, France
    Br J Anaesth 100:504-8. 2008
    ..4 or HES 200/0.6) used for the resuscitation of brain-dead donors on the rate of delayed graft function (DGF) and the serum creatinine levels post-transplantation...
  99. ncbi Initial administration of hydroxyethyl starch vs lactated Ringer after liver trauma in the pig
    M Zaar
    Department of Anaesthesia, Faculty of Health Sciences, University of Copenhagen, Denmark
    Br J Anaesth 102:221-6. 2009
    ..This study tested the circulatory effectiveness of post-trauma administration of a large intravascular volume expander, hydroxyethyl starch 130/0.4 (HES), vs standard lactated Ringer's solution (RL)...
  100. pmc Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model
    Lars Hüter
    Department of Anaesthesiology and Intensive Care Medicine, University of Jena, Erlanger Allee, Jena, Germany
    Crit Care 13:R23. 2009
    ..The aim of the study was to evaluate some of the underlying pathomechanisms of hydroxyethylstarch (HES) induced adverse effects on renal function using 24 porcine kidneys in an isolated perfusion model over six hours...

Research Grants13

  1. Phase III Study Comparing Albumin and Hetastarch Therapy in Acute Lung Injury
    Gregory S Martin; Fiscal Year: 2013
    ..This trial will also provide requisite data for any subsequent clinical trials targeted at other clinically relevant outcomes, such as mortality, the duration of mechanical ventilation, or health-related quality of life. ..
  2. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1992
    ..This research should provide new means of measuring and regulating tissue oxygen tensions and tissue oxygen availability in heart attack, stroke, cancer chemotherapy, and trauma...
  3. MECHANISMS AND PREVENTION OF HEMOGLOBIN NEUROTOXICITY
    SAMUEL PANTER; Fiscal Year: 2002
    ..These studies will delineate a hemoglobin-dependent contribution to neural injury following opening of the blood-brain barrier and will test several therapeutic candidates that could be used in the clinical setting of CABG surgery. ..
  4. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
  5. Bioengineering Methods to Study Blood Substitutes
    Anthony Cheung; Fiscal Year: 2004
    ..abstract_text> ..
  6. HYPOXIC PULMONARY VASOCANSTRICTION AND RED BLOOD CELLS
    Steven Deem; Fiscal Year: 2002
    ....
  7. Red Blood Cells, Nitric Oxide and Pulmonary Circulation
    Steven Deem; Fiscal Year: 2008
    ..abstract_text> ..
  8. Neural and non-neural modulators of skin blood flow and sweating in humans
    CRAIG CRANDALL; Fiscal Year: 2009
    ..e. diabetes, heart failure, etc) and non-disease (i.e. aging) conditions. ..
  9. Skin Cooling to Improve Orthostatic Tolerance
    CRAIG CRANDALL; Fiscal Year: 2005
    ....
  10. Patient-Oriented Cancer Research Training Program
    Emil Freireich; Fiscal Year: 2004
    ..The program will prepare oncology physician specialists for careers in academic patient-oriented research in oncology. ..
  11. Biochemical Stabilization for Freeze Dried Platelets
    Christopher Wagner; Fiscal Year: 2003
    ..abstract_text> ..
  12. Imaging Flow Cytometer
    Albert Donnenberg; Fiscal Year: 2006
    ..Should this proposal be funded, we are very well positioned to play a leading role in applying this new technology to cancer, immunology, and cell biology research. [unreadable] [unreadable]..
  13. Oxygen Carriers for Hypovolemic Circulatory Collapse
    Robert Winslow; Fiscal Year: 2007
    ..The research described in this proposal will focus on molecules and formulations specifically tailored for use in prehospital and trauma settings. ..