Summary: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

Top Publications

  1. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
  2. ncbi Prospective identification of tumorigenic prostate cancer stem cells
    Anne T Collins
    Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom
    Cancer Res 65:10946-51. 2005
  3. ncbi Identification and expansion of the tumorigenic lung cancer stem cell population
    A Eramo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cell Death Differ 15:504-14. 2008
  4. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
  5. pmc CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    Sergey V Shmelkov
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:2111-20. 2008
  6. pmc Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
    Giulia Bertolini
    Molecular Cytogenetics Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 106:16281-6. 2009
  7. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
  8. ncbi Identification of human brain tumour initiating cells
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada
    Nature 432:396-401. 2004
  9. pmc osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
  10. pmc Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness
    Paul P Szotek
    Pediatric Surgical Research Laboratories, Department of Surgery, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:11154-9. 2006

Detail Information

Publications393 found, 100 shown here

  1. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
  2. ncbi Prospective identification of tumorigenic prostate cancer stem cells
    Anne T Collins
    Yorkshire Cancer Research Unit, Department of Biology, University of York, York, United Kingdom
    Cancer Res 65:10946-51. 2005
    ..The identification of a prostate cancer stem cell provides a powerful tool to investigate the tumorigenic process and to develop therapies targeted to the stem cell...
  3. ncbi Identification and expansion of the tumorigenic lung cancer stem cell population
    A Eramo
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Cell Death Differ 15:504-14. 2008
    ..Molecular and functional characterization of such a tumorigenic population may provide valuable information to be exploited in the clinical setting...
  4. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
    ..Targeting DNA damage checkpoint response in cancer stem cells may overcome this radioresistance and provide a therapeutic model for malignant brain cancers...
  5. pmc CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    Sergey V Shmelkov
    Howard Hughes Medical Institute, Ansary Center for Stem Cell Therapeutics, and Department of Genetic Medicine, Weill Medical College of Cornell University, New York, New York, USA
    J Clin Invest 118:2111-20. 2008
  6. pmc Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
    Giulia Bertolini
    Molecular Cytogenetics Unit, Department of Experimental Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 106:16281-6. 2009
    ..The molecular features of these cells may provide the rationale for more specific therapeutic targeting and the definition of predictive factors in clinical management of this lethal disease...
  7. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
    ..The identification of a BTSC provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC...
  8. ncbi Identification of human brain tumour initiating cells
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada
    Nature 432:396-401. 2004
  9. pmc osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    N Bucay
    Department of Molecular Genetics, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Genes Dev 12:1260-8. 1998
  10. pmc Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness
    Paul P Szotek
    Pediatric Surgical Research Laboratories, Department of Surgery, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:11154-9. 2006
    ..In the future, individualized therapy must incorporate analysis of the stem cell-like subpopulation of ovarian cancer cells when designing therapeutic strategies for ovarian cancer patients...
  11. pmc Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells
    Yu Chih Chen
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 3:e2637. 2008
    ..Future research is warranted regarding the up-regulated expression of Oct-4 in LC-CD133(+) and malignant lung cancer...
  12. ncbi Glycosylation in cellular mechanisms of health and disease
    Kazuaki Ohtsubo
    Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, 9500 Gilman Drive MC0625, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 126:855-67. 2006
    ..This review discusses the increasingly sophisticated molecular mechanisms being discovered by which mammalian glycosylation governs physiology and contributes to disease...
  13. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
    ..These results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology...
  14. ncbi Identification and expansion of human colon-cancer-initiating cells
    Lucia Ricci-Vitiani
    Department of Hematology and Oncology, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Nature 445:111-5. 2007
    ..We conclude that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies...
  15. doi miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    Stephanie Ma
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong
    Cell Stem Cell 7:694-707. 2010
    ..Silencing TP53INP1 in CD133⁻ cells enhanced both self renewal and tumorigenicity in vivo. Collectively, miR-130b regulates CD133(+) liver TICs, in part, via silencing TP53INP1...
  16. pmc Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    H Hsu
    Department of Cell Biology, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Proc Natl Acad Sci U S A 96:3540-5. 1999
    ..These data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteoclast precursor cells...
  17. pmc Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    Emina H Huang
    Department of Surgery, University of Florida, Gainesville, Florida, USA
    Cancer Res 69:3382-9. 2009
    ..These findings also support our original hypothesis, derived previously from mathematical modeling of crypt dynamics, that progressive colonic SC overpopulation occurs during colon tumorigenesis and drives CRC development...
  18. pmc Cancerous stem cells can arise from pediatric brain tumors
    Houman D Hemmati
    Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:15178-83. 2003
    ..This finding may have important implications for treatment by means of specific targeting of stem-like cells within brain tumors...
  19. ncbi Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    W S Simonet
    Department of Molecular Genetics, Amgen Inc, Thousand Oaks, California 91320, USA
    Cell 89:309-19. 1997
    ..These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity...
  20. doi Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells
    Okito Hashimoto
    Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
    Pathobiology 78:181-92. 2011
    ..Intratumoral hypoxia is known to lead to increased aggressiveness and distant metastasis. However, the interplay underlying these actions is still unknown...
  21. doi Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha
    A Soeda
    Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Oncogene 28:3949-59. 2009
    ..This study illustrates the importance of the tumor microenvironment in determining cellular behavior...
  22. pmc Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer
    A Lugli
    Institute of Pathology, University of Basel, Basel, Switzerland
    Br J Cancer 103:382-90. 2010
    ..The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer...
  23. ncbi CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    S Ma
    Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Oncogene 27:1749-58. 2008
    ..Targeting of this specific survival signaling pathway in CD133+ HCC CSCs may provide a novel therapeutic model for the disease...
  24. doi CD133 expression defines a tumor initiating cell population in primary human ovarian cancer
    Michael D Curley
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Stem Cells 27:2875-83. 2009
    ..Our data indicate that CD133 expression defines a NOD/SCID tumor initiating subpopulation of cells in human ovarian cancer that may be an important target for new chemotherapeutic strategies aimed at eliminating ovarian cancer...
  25. doi GlycoWorkbench: a tool for the computer-assisted annotation of mass spectra of glycans
    Alessio Ceroni
    Division of Molecular Biosciences, Imperial College London, London SW72AZ, UK
    J Proteome Res 7:1650-9. 2008
    ..The aim of GlycoWorkbench is to offer complete support for the routine interpretation of MS data. The software is available for download from:
  26. pmc The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations
    Anna Dubrovska
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:268-73. 2009
  27. pmc Integrin alpha 6 regulates glioblastoma stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Stem Cell 6:421-32. 2010
    ..Our results provide evidence that GSCs express high levels of integrin alpha6, which can serve not only as an enrichment marker but also as a promising antiglioblastoma therapy...
  28. doi Stem cell marker CD133 affects clinical outcome in glioma patients
    Felix Zeppernick
    Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, Germany
    Clin Cancer Res 14:123-9. 2008
    ..To date, a correlation between CD133 expression in primary tumor tissues and patients' prognosis has not been reported...
  29. ncbi Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
    M Vasa
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 89:E1-7. 2001
    ..The full text of this article is available at
  30. pmc Evaluation of urine CCA assays for detection of Schistosoma mansoni infection in Western Kenya
    Hillary L Shane
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 5:e951. 2011
    ..Our results suggest that urine-based assays for CCA may be valuable in screening for S. mansoni infections...
  31. ncbi Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells
    Atsushi Suetsugu
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Biochem Biophys Res Commun 351:820-4. 2006
  32. pmc Oxidative protein folding in eukaryotes: mechanisms and consequences
    Benjamin P Tu
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA
    J Cell Biol 164:341-6. 2004
    ..How Ero1p distinguishes between the many different PDI-related proteins and how the cell minimizes the effects of oxidative damage from Ero1 remain important open questions...
  33. pmc A germin-like protein gene family functions as a complex quantitative trait locus conferring broad-spectrum disease resistance in rice
    Patricia M Manosalva
    Bioagricultural Sciences and Pest Management, Colorado State University, Fort Collins, Colorado 80523 1177, USA
    Plant Physiol 149:286-96. 2009
    ..Natural selection may have preserved a whole gene family to provide a stepwise, flexible defense response to pathogen invasion...
  34. ncbi CD133, a novel marker for human prostatic epithelial stem cells
    Gavin D Richardson
    Prostate Research Group, Surgical Oncology, Medical School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    J Cell Sci 117:3539-45. 2004
    ..alpha(2)beta(1)(hi)/CD133(+) cells exhibit two important attributes of epithelial stem cells: they possess a high in vitro proliferative potential and can reconstitute prostatic-like acini in immunocompromised male nude mice...
  35. ncbi Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005
  36. ncbi Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
    Elena Monzani
    Department of Biomolecular Science and Biotechnology, University of Milan, Milan, Italy
    Eur J Cancer 43:935-46. 2007
    ..Interestingly, considering that melanoma gives metastasis primarily through lymphatic vessels, herein, we demonstrated that a melanoma cell line expresses typical lymphoangiogenic factors...
  37. doi CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling
    Kwan Ho Tang
    Department of Pathology, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Hepatology 55:807-20. 2012
    ..Further, in its role as a liver TIC marker CD133 also plays a functional part in regulating tumorigenesis of liver TICs by way of regulating NTS, IL-8, CXCL1, and MAPK signaling...
  38. pmc CD133 expression is an independent prognostic marker for low survival in colorectal cancer
    D Horst
    Pathologisches Institut der Ludwig Maximilians Universität München, Thalkirchner Str 36, 80337 München, Germany
    Br J Cancer 99:1285-9. 2008
    ..Our results indicate that in colorectal cancer, the CD133+ tumour cells can be detected by immunohistochemistry, which facilitates their further characterisation in situ...
  39. doi Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells
    T Baba
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27708, USA
    Oncogene 28:209-18. 2009
    ..The activity of these cells may be epigenetically detected and such cells might serve as pertinent chemotherapeutic targets for reducing disease recurrence...
  40. pmc The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing
    A Sanchez
    Division of Viral and Ricketsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 93:3602-7. 1996
    ..This genetic stability may indicate that EBO viruses have coevolved with their natural reservoirs and do not change appreciably in the wild...
  41. ncbi Intracellular functions of N-linked glycans
    A Helenius
    Institute of Biochemistry, , , , Switzerland
    Science 291:2364-9. 2001
    ..These glycans are then subjected to extensive modification as the glycoproteins mature and move through the ER via the Golgi complex to their final destinations inside and outside the cell...
  42. ncbi Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    Xiaofeng Li
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, 06030, USA
    J Biol Chem 280:19883-7. 2005
  43. ncbi Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens
    Jun Miki
    Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Cancer Res 67:3153-61. 2007
    ..Expression of CXCR4 was also detected in CD133(+) cancer cells. These novel in vitro models may offer useful tools for the study of the biological features and functional integration of normal and cancer stem cells in prostate...
  44. ncbi Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 283:5866-75. 2008
  45. ncbi Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements
    Michael T Veeman
    Department of Pharmacology, Center for Developmental Biology, Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA
    Curr Biol 13:680-5. 2003
    ..Our results support the idea that a vertebrate PCP pathway regulates gastrulation movements and suggest that there is overlap between the PCP and Wnt/calcium pathways...
  46. ncbi Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys
    Costanza Sagrinati
    Interdepartmental Laboratory of Cellular and Molecular Nephrology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
    J Am Soc Nephrol 17:2443-56. 2006
  47. ncbi ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma
    Natasha Y Frank
    Department of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:4320-33. 2005
  48. ncbi A chitinase-like protein in the lung and circulation of patients with severe asthma
    Geoffrey L Chupp
    Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 357:2016-27. 2007
    ..The related chitinase-like protein, YKL-40 (also called human cartilage glycoprotein 39 [HCgp-39] and chitinase 3-like 1), can be readily measured in the serum. However, its relationship to asthma has not been evaluated...
  49. ncbi CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity
    Shengyong Yin
    Department of General Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, People s Republic of China
    Int J Cancer 120:1444-50. 2007
    ..The implication that CD133 might be one of the markers for HCC cancer stem-like cells needed further investigation...
  50. ncbi Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells
    Anne Marie Marzesco
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    J Cell Sci 118:2849-58. 2005
    ..Moreover, the presence of prominin-1-containing membrane particles in human body fluids may provide the basis for a protein-based diagnosis of certain diseases...
  51. ncbi Respiratory tract mucin genes and mucin glycoproteins in health and disease
    Mary Callaghan Rose
    Research Center for Genetic Medicine, Room 5700, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Physiol Rev 86:245-78. 2006
    This review focuses on the role and regulation of mucin glycoproteins (mucins) in airway health and disease. Mucins are highly glycosylated macromolecules (> or =50% carbohydrate, wt/wt)...
  52. pmc Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
    Jeffrey E Lee
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Drop IMM 2, La Jolla, California 92037, USA
    Nature 454:177-82. 2008
    ..This structure provides a template for unravelling the mechanism of EBOV GP-mediated fusion and for future immunotherapeutic development...
  53. doi CD133 as a marker for cancer stem cells: progresses and concerns
    Yaojiong Wu
    Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen, People s Republic of China
    Stem Cells Dev 18:1127-34. 2009
    ..In this review, we summarize findings in CD133 expression in various tissues and critically discuss its applications in stem cell isolation...
  54. pmc Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses
    Sheli R Radoshitzky
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
    Nature 446:92-6. 2007
    ..These data indicate that TfR1 is a cellular receptor for New World haemorrhagic fever arenaviruses...
  55. ncbi Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
    S G M Piccirillo
    Department of Biotechnology and Biosciences, University of Milan Bicocca, 20126 Milan, Italy
    Nature 444:761-5. 2006
  56. doi Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Ann Surg Oncol 16:3488-98. 2009
    ..We investigated the role of three stem cell markers (CD133, OCT4, and SOX2) in rectal cancer and evaluated the association between these gene levels and clinical outcome in rectal cancer patients with preoperative CRT...
  57. ncbi A Drosophila homolog of cadherin associated with armadillo and essential for embryonic cell-cell adhesion
    H Oda
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 165:716-26. 1994
    ..All these results suggest that DE-cadherin is a homolog of vertebrate classic cadherins and that the vertebrate and invertebrate share common mechanisms for regulation of cell-cell adhesion...
  58. ncbi Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro
    H Yasuda
    Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, Tochigi, Japan
    Endocrinology 139:1329-37. 1998
    ..These results suggest that the sites are involved in cell-to-cell signaling between stromal cells and osteoclast progenitors and that OPG/OCIF inhibits osteoclastogenesis by interrupting the signaling through the sites...
  59. doi Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations
    Stephanie Ma
    Department of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong, China
    Mol Cancer Res 6:1146-53. 2008
    ..ALDH, expressed along CD133, can more specifically characterize the tumorigenic liver CSC population...
  60. pmc Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins
    Bernd Wollscheid
    Institute for Systems Biology, Seattle, WA, USA
    Nat Biotechnol 27:378-86. 2009
    ..identification of several hundred N-linked glycosylation sites specifically from cell surface-exposed glycoproteins to phenotype cells without antibodies in an unbiased fashion and without a priori knowledge...
  61. ncbi gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells
    Kimi C Nishikawa
    Department of Biological Sciences, 1400 Washington Avenue, University at Albany SUNY, 1400 Washington Avenue, Albany, NY 12222, USA
    Exp Cell Res 287:79-87. 2003
    ..gp38k may interact with VSMC via an EDTA-sensitive mechanism consistent with integrin mediated cell-matrix interaction...
  62. pmc BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum
    Jasper H L Claessen
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS ONE 6:e28542. 2011
    ..Cells depleted of BAT3 fail to degrade an established dislocation substrate. We thus implicate a cytosolic chaperone as an active participant in the dislocation of ER glycoproteins.
  63. pmc Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p
    Einav Gross
    Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 103:299-304. 2006
    ..These findings provide insight into mechanisms for regenerating oxidized Ero1p and maintaining disulfide bond formation under anaerobic conditions in the endoplasmic reticulum...
  64. doi A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells
    Hiroe Go
    Department of Food Science and Biotechnology, Pukyong National University, Busan, South Korea
    Toxicol In Vitro 24:1546-53. 2010
    ..Therefore, LJGP can be a useful treatment option for colon cancer in humans...
  65. doi A role for cancer stem cells in drug resistance and metastasis in non-small-cell lung cancer
    Rosario Perona
    Instituto de Investigaciones Biomedicas CSIC UAM, CIBER de Enfermedades Raras, IdiPAZ, Madrid, Spain
    Clin Transl Oncol 13:289-93. 2011
    ..Therefore, understanding the biology and exploring cell markers and signalling pathways specific for CSCs of lung cancer may help in achieving progress in the treatment of the disease...
  66. pmc Regeneration of glomerular podocytes by human renal progenitors
    Elisa Ronconi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
    J Am Soc Nephrol 20:322-32. 2009
  67. pmc Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein
    Martin Harterink
    Hubrecht Institute, Royal Academy of Arts and Sciences and University Medical Center Utrecht, Uppsalalaan 8, Utrecht, The Netherlands
    Development 138:2915-24. 2011
    ..Our results in C. elegans support the notion that a system of posterior Wnt signaling and anterior Wnt inhibition is an evolutionarily conserved principle of primary body axis specification...
  68. pmc Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P
    Winfried R Beyer
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, D 20251 Hamburg, Germany
    J Virol 77:2866-72. 2003
    ..In agreement with the identified consensus motif, we show that the cellular subtilase SKI-1/S1P cleaves LCMV GP...
  69. doi CD133+ liver cancer stem cells modulate radioresistance in human hepatocellular carcinoma
    Lian Shu Piao
    WHO Collaborating Center of Viral Hepatitis, The Catholic University of Korea, Seoul 137 701, Republic of Korea
    Cancer Lett 315:129-37. 2012
    ..Therefore, CD133-expressing liver cancer cells have anti-apoptotic and radioresistance properties that may be useful to improve anti-cancer treatments, including chemotherapy/radiotherapy of HCC...
  70. ncbi Endothelial progenitor cells: mobilization, differentiation, and homing
    Mihail Hristov
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
    Arterioscler Thromb Vasc Biol 23:1185-9. 2003
    ..Thus, future studies will help to explore areas of potential basic research and clinical application of EPCs...
  71. pmc A system for functional analysis of Ebola virus glycoprotein
    A Takada
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, 332 North Lauderdale, P O Box 318, Memphis, TN 38101, USA
    Proc Natl Acad Sci U S A 94:14764-9. 1997
    ..To circumvent this problem, we developed a novel complementation system for functional analysis of Ebola virus glycoproteins. It relies on a recombinant vesicular stomatitis virus (VSV) that contains the green fluorescent protein gene ..
  72. doi The genetics of primary open-angle glaucoma: a review
    R Rand Allingham
    Duke University Eye Center, Duke University, Durham, NC 27710, USA
    Exp Eye Res 88:837-44. 2009
    ..This review examines what is currently known about the underlying genetic structure, what remains to be learned, and how this may affect our medical management of this major blinding disease...
  73. doi Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease
    Paola Bovolenta
    Departamento de Neurobiología Molecular, Celular y del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    J Cell Sci 121:737-46. 2008
    ..Here we review some of the debated aspects of SFRP-Wnt interactions and discuss the new and emerging roles of SFRPs...
  74. ncbi A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems
    Nicholas J Agard
    Department of Chemistry, Howard Hughes Medical Institute, University of California, and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Am Chem Soc 126:15046-7. 2004
    ..The utility of the reaction was demonstrated by selective modification of biomolecules in vitro and on living cells, with no apparent toxicity...
  75. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues...
  76. pmc Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB
    Chun Yan Li
    Biotherapy Center, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China
    J Transl Med 7:56. 2009
  77. pmc Differential effects of EGFR ligands on endocytic sorting of the receptor
    Kirstine Roepstorff
    Department of Cellular and Molecular Medicine, The Panum Building, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Traffic 10:1115-27. 2009
    ..The Cbl ubiquitin ligases, especially c-Cbl, are responsible for EGFR ubiquitination after stimulation with all ligands, and persistent EGFR phosphorylation and ubiquitination largely correlate with receptor degradation...
  78. pmc Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma
    Dongho Choi
    Department of Pathology, College of Medicine, Hanyang University, Seoul, South Korea
    World J Gastroenterol 15:2258-64. 2009
    ..To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon cancer...
  79. doi mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells
    Kazuko Matsumoto
    Department of Genome Biology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Cancer Res 69:7160-4. 2009
  80. pmc Functional analysis of recombinant respiratory syncytial virus deletion mutants lacking the small hydrophobic and/or attachment glycoprotein gene
    S Techaarpornkul
    Department of Immunology/Microbiology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA
    J Virol 75:6825-34. 2001
    Respiratory syncytial virus (RSV) produces three envelope glycoproteins, the attachment glycoprotein (G), the fusion (F) protein, and the small hydrophobic (SH) protein...
  81. ncbi CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
    Jian Wang
    Department of Biomedicine, University of Bergen, Bergen, Norway
    Int J Cancer 122:761-8. 2008
    ..Thus, our findings do not suggest that CD133 expression is required for brain tumor initiation, but that it may be involved during brain tumor progression...
  82. pmc Neurexin-neuroligin signaling in synapse development
    Ann Marie Craig
    Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 2B5, Canada
    Curr Opin Neurobiol 17:43-52. 2007
  83. ncbi Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding
    Andrei J Petrescu
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U K
    Glycobiology 14:103-14. 2004
    ..We surveyed 506 glycoproteins in the Protein Data Bank crystallographic database, giving 2592 glycosylation sequons (1683 occupied) and ..
  84. pmc The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding
    Derek Dube
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908 0732, USA
    J Virol 83:2883-91. 2009
  85. ncbi Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice
    Alfred R Oliver
    Department of Epidemiology and Public Health and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 171:462-8. 2003
  86. ncbi Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis
    Markus Missler
    Center for Basic Neuroscience, Department of Molecular Genetics, Dallas, Texas 75390 9111, USA
    Nature 423:939-48. 2003
    ..These data suggest that alpha-neurexins organize presynaptic terminals by functionally coupling Ca2+ channels to the presynaptic machinery...
  87. pmc The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells
    Donald J Vander Griend
    Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Brady Urological Institute, and Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 68:9703-11. 2008
  88. ncbi Osteoclast differentiation and activation
    William J Boyle
    Protein Pathways, Inc, Woodland Hills, California 91367, USA
    Nature 423:337-42. 2003
    ..Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss...
  89. doi Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength
    Xiaodong Li
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California 91320 1799, USA
    J Bone Miner Res 23:860-9. 2008
    ..Based on these data, sclerostin has emerged as a key negative regulator of bone mass. We generated SOST knockout (KO) mice to gain a more detailed understanding of the effects of sclerostin deficiency on bone...
  90. ncbi Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    Patrick C Hermann
    Department of Surgery, Ludwig Maximilians University, 81377 Munich, Germany
    Cell Stem Cell 1:313-23. 2007
    ..Strategies aimed at modulating the SDF-1/CXCR4 axis may have important clinical applications to inhibit metastasis of cancer stem cells...
  91. pmc Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma
    Ralph A Francescone
    Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 286:15332-43. 2011
    ..These findings have shed light on the mechanisms by which YKL-40 promotes tumor angiogenesis and malignancy, and thus provide a therapeutic target for tumor treatment...
  92. pmc Primary open-angle glaucoma genes
    J H Fingert
    Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Eye (Lond) 25:587-95. 2011
    ..Each of these different approaches to study glaucoma genetics is providing new insights into the pathogenesis of POAG...
  93. ncbi Expression of CD133-1 and CD133-2 in ovarian cancer
    G Ferrandina
    Gynecologic Oncology Unit, Catholic University of the Sacred Heart, Rome, Italy
    Int J Gynecol Cancer 18:506-14. 2008
    ..CD133-1 and CD133-2 may be useful in order to select and enrich the population of CD133(+) ovarian tumor cells, which are characterized by a higher clonogenic efficiency and proliferative potential...
  94. doi Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer
    Hisae Iinuma
    Department of Surgery, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo, 173 0003, Japan
    J Clin Oncol 29:1547-55. 2011
  95. doi Glycoprotein folding, quality control and ER-associated degradation
    Gerardo Z Lederkremer
    Department of Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Curr Opin Struct Biol 19:515-23. 2009
    Nascent N-linked glycoproteins possess a large oligosaccharide precursor, Glc(3)Man(9)GlcNAc(2), which is later sequentially trimmed...
  96. doi Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling
    Chuwen Lin
    Bio X Center, Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    J Bone Miner Res 24:1651-61. 2009
    ..Our findings also indicated sclerostin is a promising target for preventing disuse osteoporosis...
  97. pmc Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:1149-66. 2009
    ..These studies establish novel regulatory roles for BRP-39/YKL-40 in the initiation and effector phases of Th2 inflammation and remodeling and suggest that these proteins are therapeutic targets in Th2- and macrophage-mediated disorders...
  98. ncbi A perivascular niche for brain tumor stem cells
    Christopher Calabrese
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Cancer Cell 11:69-82. 2007
    ..We propose that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches...
  99. ncbi Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    D L Lacey
    Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
    Cell 93:165-76. 1998
    ..These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development...
  100. pmc Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048, USA
    Mol Cancer 5:67. 2006
    ..The gene expression and the drug resistance property of CD133 positive cancer stem cells, however, are still unknown...
  101. doi 5-AZA-2'-deoxycytidine induced demethylation influences N-glycosylation of secreted glycoproteins in ovarian cancer
    Radka Saldova
    Dublin Oxford NIBRT Glycobiology Laboratory, NIBRT, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Epigenetics 6:1362-72. 2011
    ..ovarian cancer epithelial cells (OVCAR3) resulted in significant alterations in the glycosylation of secreted glycoproteins. These changes included a reduction in core fucosylation, increased branching and increased sialylation...

Research Grants78

  1. Correction of glutathione deficiency for treatment of diabetic nephropathy
    Paolo Fanti; Fiscal Year: 2013
    ..In addition, we will analyze the plasma and urine glycoproteome, with focus on those glycoproteins serving as inflammatory cell messengers and hormones...
  2. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..cooperate to regulate binding to galectins and thereby the distribution, clustering and endocytosis of surface glycoproteins in a predictable manner...
    Pi Wan Cheng; Fiscal Year: 2010
    ..Current studies could facilitate the development of therapy for mucus hypersecretory diseases through identification of small carbohydrate inhibitors and mucus cell-specific promoter. ..
  4. Viral and Host Determinants of New World Alphaviral Entry
    ASIM AMINSHARIF AHMED; Fiscal Year: 2013
    ..these limitations, we have developed "pseudotyped" viruses, which contain the EEEV, WEEV or VEEV envelope glycoproteins on their surface and express a reporter gene as a marker of infection...
  5. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..In addition, our studies will measure the magnitude of such interactions. The results of our study should lead to better management of drug therapy and improvement of the drug development process. ..
  6. Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
    JEAN CLAIRE LEE; Fiscal Year: 2013 able to transfer an oligosaccharide to a protein consensus sequence, thereby allowing the production of glycoproteins in bacterial cells...
  7. N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
    Paolo Fanti; Fiscal Year: 2011
    ..In addition, we will analyze the plasma and urine glycoproteome, with focus on those glycoproteins serving as inflammatory cell messengers and hormones...
  8. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    ..We constructed a panel of isogenic SARS-CoV strains bearing spike (S) glycoproteins derived from animal and human strains (e.g., civet, raccoon dog, human)...
    ..Future intervention trials will address these metabolic and nutritional issues, to reduce early ART mortality and improve ART outcomes in resource-constrained settings. ..
    Vijay Sharma; Fiscal Year: 2013
    ..Successful execution of the outlined objectives should provide a molecular-targeted 68Ga-PET agent for MPI and management of CAD. ..
  11. Biofilm Infections in Postsurgical, Trauma, and Critically Ill Patients
    Carol L Wells; Fiscal Year: 2013
    ..growing on a surface and surrounded by a complex extracellular polymeric substance composed of proteins, glycoproteins, glycolipids, polysaccharides, and DNA...
  12. Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
    William A Banks; Fiscal Year: 2013
    ..abstract_text> ..
  13. Varicella zoster virus: molecular controls of cell fusion-dependent pathogenesis
    Ann Arvin; Fiscal Year: 2013
  14. Human cytomegalovirus entry into epithelial and endothelial cells
    David C Johnson; Fiscal Year: 2013
    ..strains of HCMV enter all these diverse cell types, apparently because these viruses express two entry glycoproteins: gH/gL/UL128-131, required for entry into epithelial and endothelial cells and gH/gL/gO, required for entry ..
    Kwang Chul Kim; Fiscal Year: 2010
    ..In this project, we will try to understand the mechanism at the cellular and molecular level. Successful completion of this project will shed valuable insights in our understanding of the development of asthma. ..
  16. Control of alphavirous replacation in the nervous system
    Diane E Griffin; Fiscal Year: 2013
  17. Characterize functions of T. brucei RAP1 and TRF in antigenic variation and telom
    Bibo Li; Fiscal Year: 2013
    ..Identification of novel factors involved in antigenic variation also provides more potential targets for anti-parasite drugs and helps for eventual elimination of this parasite. ..
  18. Carbohydrate-based Antiinfective Agents
    Chi Huey Wong; Fiscal Year: 2013
    ..Hemagglutinin (HA) and neuraminidase (NA) are influenza coat glycoproteins that are susceptible to inhibition by sialic acid derivatives, which interfere with necessary recognition of ..
  19. Novel Chaperone Mechanism for Platelet Disorder
    Zihai Li; Fiscal Year: 2010
    ..Successful execution of this study may lead to new understanding of the causes of BSS and potential novel treatments of BSS and other platelet disorders. ..
  20. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..These molecules include glycoproteins such as the neural cell adhesion molecule, GPI-anchored proteins such as acetylcholinesterase, glycolipids ..
    Namasivayam Ambalavanan; Fiscal Year: 2012
    Arthur A Vandenbark; Fiscal Year: 2013
    ..Our studies will provide unique insights into the mechanisms of RTL therapy for EAE in mice, with implications for similar evaluations in subjects with MS. ..
  23. Genetic Determinants of the Response to Thienopyridine Therapy
    Jessica L Mega; Fiscal Year: 2013
    ..The TIMI Study Group also offers the appropriate training environment to provide Dr. Mega with the skills needed to lead the multicenter clinical trial described in Aim 3. ..
  24. Development of an effective genital herpes vaccine
    William P Halford; Fiscal Year: 2010
    ..It is anticipated that a new live HSV-2 ICP0- vaccine strain will emerge from these studies that warrants advancement to human clinical trials. ..
  25. Cellular Components Involved in Japanese Encephalitis Virus Entry
    Young Min Lee; Fiscal Year: 2013
  26. HIV and CD16+ monocytes as cellular reservoir &HIV/pulmonary hypertension
    Sharilyn Almodovar; Fiscal Year: 2013
    ..We will use several laboratory techniques single-genome amplification, phylogenetic analyses, cell isolation using magnetic beads, fluorescent in itu hybridization and in vivo cell imaging. ..
  27. Mechanistic Studies of HCV E2
    Joseph Marcotrigiano; Fiscal Year: 2013
    ..The HCV virion consists of a membrane enveloped nucleocapsid and two glycoproteins (E1 and E2), which are important for recognizing and entering a target host cell...
  28. Nanotheranostics for Early Colorectal Cancer Detection and Treatment
    Jeffrey S Souris; Fiscal Year: 2013
  29. Development of transformed lactobacilli as a microbicide
    Richard B Markham; Fiscal Year: 2010
  30. A Molecular targeting agent for systemic radiotherapy of metastatic Prostate Canc
    Kevin P Maresca; Fiscal Year: 2010
    ..This proposal is designed to generate the pre-clinical efficacy data for the corresponding therapeutic I-131-MIP-1072 in order to assess the possibilities of developing the imaging agent into an effective treatment for prostate cancer. ..
  31. Cytosine DNA Methylation and Transcriptional Repression in African Trypanosomes
    KEVIN MILITELLO; Fiscal Year: 2012
    ..Engineered parasites lacking DNA methylation may over-express surface antigens and serve as a vaccine. ..
    Jerry Ware; Fiscal Year: 2012
    ..An understanding of how platelets function in the process will lead to better therapeutic strategies and improved health in the U.S. ..
  33. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    ..The glycans are intimately involved in folding of N-glycoproteins, and can also participate in their functions after secretion or reaching the cell surface...
  34. Identification and characterization of inhibitors for hantavirus replication
    MOHAMMAD AYOUB MIR; Fiscal Year: 2013
    ..selectively transports the nucleocapsids to specific destinations on Golgi membranes that are studded with the glycoproteins. Thus, the specific interaction between Gn cytoplasmic tail domain and N-panhandle complex likely mediates the ..
    Anne M Delany; Fiscal Year: 2013
    ..Information obtained from these studies could be used to identify novel targets for therapeutic intervention in the treatment of osteoporosis, and may be used to identify individuals at risk for developing osteoporosis. ..
  36. VEE Virus Infection on the Mosquito Vector
    Scott C Weaver; Fiscal Year: 2013
    ..The results will add to our understanding of the mechanisms of epidemic VEEV emergence and provide new viral and host targets for the development of safer vaccines and novel strategies to interrupt transmission. ..
  37. Characterizaton of Motility Factor Receptor
    Avraham Raz; Fiscal Year: 2012
    ..It is expected that these studies will lead to a better diagnosis, treatment and development of rational therapy. ..
  38. Novel vaccine to CMV based on a disc virus
    Alistair McGregor; Fiscal Year: 2010
    ..Additionally, a vaccine would save considerably in the resources currently employed for the long term treatment/ care of congenitally infected newborns with severe hearing loss and mental retardation. ..
  39. Advancing a Lead Candidate Hantavirus Pulmonary Syndrome DNA Vaccine
    JAY WILLIAMS HOOPER; Fiscal Year: 2013
    ..The vaccine is a DNA vaccine consisting of two plasmids that encode the surface glycoproteins of ANDV and SNV...
  40. Development of CNS-targeted AAV vectors
    MIGUEL S ESTEVES; Fiscal Year: 2012
    ..of CNS-targeted AAV vectors to foster the development of highly effective gene therapy approaches to treat many childhood, adult, and geriatric neurological diseases currently beyond the reach of modern medicine ..
    Hans Schreiber; Fiscal Year: 2013
    ..and pancreas) have defects in O-linked glycosylation thereby generating tumor-specific epitopes on surface glycoproteins of cancer cells...
  42. DC-SIGN Inhibitors for the Treatment of HIV Infection
    ALLEN BERNARD REITZ; Fiscal Year: 2013
  43. Development of a novel vaccine against congenital cytomegalovirus infection
    Christopher S Morello; Fiscal Year: 2010
  44. Impact of genetic variation on response to GO therapy in COG-AML clinical trials
    ROLAND BRUNO WALTER; Fiscal Year: 2013
    ..Moreover, this research will provide novel insights into the impact of genetic polymorphisms on efficacy of standard therapeutics with broad implications for the treatment of AML. ..
  45. Investigation of Nephrotic Syndrome
    LIONEL CLAUDIUS CLEMENT; Fiscal Year: 2013
    ..In Specific Aim 3, putative interactions of Angptl4 with apolipoproteins C-II (activator of lipoprotei lipase) and C-III, (inhibitor of lipoprotein lipase) on the surface of HDL will be studied. ..
  46. Homing of Stem Cells in Stroke Therapeutics
    EVAN YALE contact SNYDER; Fiscal Year: 2010
    ..hNSCs following peripheral administration 24 hrs post-stroke, particularly under conditions where their homing has been optimized by fucosylation. ..
  47. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..In addition, we have demonstrated that HMW1 and HMW2 are glycoproteins and are modified by a glycosyltransferase called HMW1C or HMW2C, capable of transferring hexose units to ..
  48. H. influenzae: Role of Sialic Acid in Virulence
    Michael A Apicella; Fiscal Year: 2013
    ..the mechanism(s) by which nontypeable Haemophilus influenzae (NTHi) scavenges sialic acid from airway glycoproteins. Studies are also proposed which will elucidate the role of the non-sialylated lipooligosaccaride in ..
    Vijay K Kuchroo; Fiscal Year: 2013
    ..Using "reporter" mice for effector and regulatory T cells and autoantigen specific tetramers, we will be able to study the balance and interplay between antigen- specific effector and regulatory T cells during the autoimmune reaction. ..
  50. Leukemia Inhibitory Factor As a Mediator of Primate Ovulation &Oocyte Maturation
    Jon D Hennebold; Fiscal Year: 2013
    ..e., pre-hCG) will be directly exposed to LIF to determine a direct effect of this cytokine on promoting C-OE, reinitiation of meiosis, fertilization, and embryonic development. ..
  51. IL8-induced Post-transcriptional Regulation of the MUC5AC mucin gene
    Mary C Rose; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Secretory mucin glycoproteins are the major macromolecular component of lung mucus, which coats and protects the respiratory tract...
  52. Novel Approach to Oral Gene Therapy for Chronic Granulomatous Disease
    Peter E Newburger; Fiscal Year: 2010
    ..The findings would provide a strong basis for translational research culminating in clinical trials for human gene therapy for the disease. ..
  53. Mechanism of murine coronavirus induced hepatitis
    Susan R Weiss; Fiscal Year: 2010
    ..Elucidation of the mechanism of MHV induced demyelination will contribute to the understanding of hepatitis in humans and in the long term contribute to the design of anti-viral therapies ..
  54. WNT and gonadotropin mediated regulation of ovarian steroidogenesis
    ..WNTs comprise a family of secreted glycoproteins that are key extracellular signaling proteins necessary for early ovarian development and steroidogenesis;..
  55. Individual Predoctoral Dental Scientist Fellowship
    Angela Gullard; Fiscal Year: 2013
    ..This research will elucidate the role of tooth/bone matrix material properties in oral and skeletal health and disease. ..
    Richard J Kuhn; Fiscal Year: 2013
    ..High resolution atomic structures of the alphavirus nucleocapsid protein and the envelope glycoproteins will be used in conjunction with pseudo-atomic resolution cryo-electron microscopy image reconstructions as a ..
  57. The Impact of Oxidative Stress on HIV-induced Lung Disease
    Jesse Roman; Fiscal Year: 2013
    ..cellular products with pro-inflammatory and pro-fibrotic effects such as cytokines and growth factors, matrix glycoproteins, and tissue proteases...
  58. Development of a Novel Vaccine Against Herpes Simplex Type 2
    DEBORAH SPECTOR; Fiscal Year: 2009
    ..S. population together with the medical and psychological impacts of the disease make HSV-2 an important candidate for the development of an effective vaccine that can prevent infection or disease. ..
    DAVID WILLIAM SCOTT; Fiscal Year: 2013
    ..These studies will establish a novel approach for tolerance with human T cells in a clinically relevant model, and will continue the translation of this project forward to the clinic as a potential therapy for multiple sclerosis. ..
  60. Mechanics of Inner Ear Hair Bundles
    ..If necessary, CNTs will be coated with glycoproteins or stereociliaspecific antibodies to promote adhesion...
  61. Photocrosslinking characterization of heat-labile toxin glycoreceptors
    Amberlyn M Wands; Fiscal Year: 2013
    ..These experiments will mark an important achievement in understanding the relevant proteins involved in ETEC mediated disease, and thus uncover novel therapeutic targets to complement existing treatments. ..
  62. Nanoliposome-based Treatment of Amyloid Protein (AL) Toxicity
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2013
  63. Excitation-contraction Coupling in Normal and Dystrophic Mammalian Muscle
    Julio L Vergara; Fiscal Year: 2013
    ..The results will significantly broaden our understanding of muscle disease mechanisms and will potentially provide therapeutic molecular tools which are deemed necessary for further advances in gene therapy. ..
  64. A novel transgenic silkworm system for recombinant glycoprotein production
    Donald L Jarvis; Fiscal Year: 2010
    ..significant proteins, including antibodies, cytokines, anticoagulants, blood clotting factors, and others are glycoproteins. Thus, there is a high demand for systems that can be used to produce recombinant glycoproteins for basic ..
    Jacques U Baenziger; Fiscal Year: 2010
    ..beta1,2Manα-, rather than the sequence Gal beta1,4GlcNAc beta1,2Manα- that is found on many glycoproteins. The beta1,4-N-acetylgalactosaminyl-transferases ( betaGTs) that add GalNAc to this structure are protein-..
  66. High Mannose Type Carbohydrate-based HIV/AIDS Vaccine
    Yu Geng; Fiscal Year: 2009
    ..cerevisiae, identified several yeast glycoproteins that cross-react with 2G12, elicited immune sera that cross-react with Env glycoproteins of HIV-1 and SIV, and ..
    Herman van Halbeek; Fiscal Year: 1993
    ..These variant surface glycoproteins (VSGs) have one or more N-linked glycans and are anchored in the trypanosome membrane by a glycosyl-..
  68. The Role of P-glycoprotein in Sitagliptin Clinical Pharmacology
    Christina L Aquilante; Fiscal Year: 2010
    ..e., clinical pharmacology). The aims of this application are to investigate the clinical pharmacology of sitagliptin in order to promote its safe and effective use in patients with type 2 diabetes. ..
    JEFFREY GORSKI; Fiscal Year: 1991
  70. Chemical tools to understand and target Helicobacter pylori glycosylation
    Danielle H Dube; Fiscal Year: 2010
    ..expand the recently introduced technique of metabolic oligosaccharide engineering (MOE) to study and perturb glycoproteins of the pathogen Hp...
  71. Structural, genetic, and functional analyses of the glycoproteins of Bacteroides
    LAURIE COMSTOCK; Fiscal Year: 2009
    ..The experiments outlined in this proposal are designed to characterize a novel and abundant class of bacterial glycoproteins that are synthesized by the predominant bacteria of the mammalian intestine, namely the Bacteroides...
    Joseph Mendicino; Fiscal Year: 1990
    ..clinical abnormalities in this disease are the result of an alteration in the viscollastic properties of mucin glycoproteins present in mucus secretions...
    Edward Stephens; Fiscal Year: 1990
    ..The expressed glycoproteins have been demonstrated to be properly processed and glycosylated and when used as live virus vaccines have ..
  74. Thrombus Formation Initiation and Propagation
    Barbara Furie; Fiscal Year: 2007
    ..To complement our in vivo studies of the role of factor XI in thrombus formation the structure of the complex formed between the factor XI apple domain(s)and the factor IX Gla domain will be determined. ..
  75. T. gondii as a model for investigation of Cryptosporidium glycoprotein antigens
    ROBERTA M O apos CONNOR; Fiscal Year: 2010
    ..To date there is no effective treatment or vaccine for Cp. Studies suggest that Cp relies on mucin- like glycoproteins to attach to and invade intestinal epithelial cells...
    PAUL WASSARMAN; Fiscal Year: 2007
    ..The mouse egg ZP consists of three glycoproteins, called mZP1-3...
    Paul Atkinson; Fiscal Year: 1991
    ..membrane glycoprotein genes will be used to probe the primary sequence requirements directing the sorting of glycoproteins into specific membrane compartments...
  78. Mannosidase inhibitors as therapeutics for glycoprotein misfolding diseases
    Kelley W Moremen; Fiscal Year: 2010
    ..This enzyme, ERalpha-mannosidase I (ERManl), acts as a key timer for ER residence for newly synthesized glycoproteins by initiating a rate-limiting step leading to a cascade of interactions that ultimately leads to the targeting ..