recombinant interferon gamma

Summary

Summary: A type II interferon produced by recombinant DNA technology. It is similar to the interferon secreted by lymphocytes and has antiviral and antineoplastic activity.

Top Publications

  1. ncbi IFN-gamma induces IL-12 mRNA expression by a murine macrophage cell line, J774
    A Yoshida
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Japan
    Biochem Biophys Res Commun 198:857-61. 1994
  2. ncbi Inhibition of inducible nitric-oxide synthase expression by (5R)-5-hydroxytriptolide in interferon-gamma- and bacterial lipopolysaccharide-stimulated macrophages
    Ru Zhou
    Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Rd, Zhangjiang Hi Tech Park, Shanghai 201203, People s Republic of China
    J Pharmacol Exp Ther 316:121-8. 2006
  3. ncbi MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA
    Dongxu Sun
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Immunol 7:375-81. 2006
  4. ncbi A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
    Ganesh Raghu
    Division of Pulmonary Medicine, University of Washington, Seattle 98195, USA
    N Engl J Med 350:125-33. 2004
  5. pmc Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
    P Kovarik
    Vienna Biocenter, Institute of Microbiology and Genetics, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    EMBO J 20:91-100. 2001
  6. pmc Expression and characterization of recombinant interferon gamma (IFN-gamma) from the nine-banded armadillo (Dasypus novemcinctus) and its effect on Mycobacterium leprae-infected macrophages
    M T Pena
    DHHS HRSA BPHC, National Hansen s Disease Program, LSU School of Veterinary Medicine, Microbiology Research Department, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Cytokine 43:124-31. 2008
  7. ncbi Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death
    Helen E Thomas
    St Vincent s Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:20-7. 2006
  8. pmc Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells
    Dongli Yang
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105 0714, USA
    Exp Eye Res 85:462-72. 2007
  9. ncbi Long-term clinical effects of interferon gamma-1b and colchicine in idiopathic pulmonary fibrosis
    K M Antoniou
    Dept of Pneumonology, Medical School, University of Crete, Iraklion, Greece
    Eur Respir J 28:496-504. 2006
  10. pmc Adjuvant interferon gamma in patients with drug - resistant pulmonary tuberculosis: a pilot study
    Roberto Suárez-Méndez
    Benéfico Jurídico Hospital, Havana, Cuba
    BMC Infect Dis 4:44. 2004

Research Grants

  1. WHITE BLOOD CELL OXIDASE IN LEUKEMIA AND NORMAL CELLS
    Peter Newburger; Fiscal Year: 1991
  2. INDOLEAMINE 2,3-DIOXYGENASE IN OPPORTUNISTIC INFECTIONS
    SOHAN GUPTA; Fiscal Year: 1992
  3. MOLECULAR BASIS OF INTERFERON ACTION--RELATION TO M.S.
    Richard Ransohoff; Fiscal Year: 1992
  4. OPTIMIZATION OF MONOCLONAL ANTIBODY LOCALIZATION
    James Murray; Fiscal Year: 1991
  5. Role of LRP in Astrocytoma Migration
    Isa Hussaini; Fiscal Year: 2007
  6. Macrophage Dysfunction in Immunosenescence
    Robert Stout; Fiscal Year: 2006
  7. Induction of suppression for Islet Transplantation
    Zandong Yang; Fiscal Year: 2003
  8. Tumor Induced Dysregulation of T Cell Immunity
    James H Finke; Fiscal Year: 2010
  9. STROMELYSIN 3 AND THE TUMOR MICROENVIRONMENT
    Margaret Shipp; Fiscal Year: 2002
  10. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010

Detail Information

Publications249 found, 100 shown here

  1. ncbi IFN-gamma induces IL-12 mRNA expression by a murine macrophage cell line, J774
    A Yoshida
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Japan
    Biochem Biophys Res Commun 198:857-61. 1994
    ..The IFN-gamma-inducible IL-12 mRNA was blocked by two protein tyrosine kinase (PTK) inhibitors, genistein and herbimycin A, suggesting that PTK is involved in the IFN-gamma-inducible IL-12 mRNA expression...
  2. ncbi Inhibition of inducible nitric-oxide synthase expression by (5R)-5-hydroxytriptolide in interferon-gamma- and bacterial lipopolysaccharide-stimulated macrophages
    Ru Zhou
    Laboratory of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Rd, Zhangjiang Hi Tech Park, Shanghai 201203, People s Republic of China
    J Pharmacol Exp Ther 316:121-8. 2006
    ..Taken together, these results suggest that LLDT-8 reduces NO production and iNOS expression by inhibiting IFN-gamma-triggered IRF-1 expression and LPS-triggered MAPK phosphorylation and NF-kappaB activation...
  3. ncbi MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA
    Dongxu Sun
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Immunol 7:375-81. 2006
    ..These results demonstrate a MyD88-dependent post-transcriptional mechanism through which IFN-gamma can enhance the expression of genes encoding proinflammatory molecules...
  4. ncbi A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis
    Ganesh Raghu
    Division of Pulmonary Medicine, University of Washington, Seattle 98195, USA
    N Engl J Med 350:125-33. 2004
    ..Idiopathic pulmonary fibrosis is a progressive, fatal disease with no known efficacious therapy...
  5. pmc Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
    P Kovarik
    Vienna Biocenter, Institute of Microbiology and Genetics, Dr Bohr Gasse 9, A 1030 Vienna, Austria
    EMBO J 20:91-100. 2001
    ....
  6. pmc Expression and characterization of recombinant interferon gamma (IFN-gamma) from the nine-banded armadillo (Dasypus novemcinctus) and its effect on Mycobacterium leprae-infected macrophages
    M T Pena
    DHHS HRSA BPHC, National Hansen s Disease Program, LSU School of Veterinary Medicine, Microbiology Research Department, Skip Bertman Drive, Baton Rouge, LA 70803, USA
    Cytokine 43:124-31. 2008
    ..leprae in vitro. These data indicate that the response of armadillo MPhi to rDnIFN-gamma is similar to that which occurs in humans, and demonstrates a potentially important value of the armadillo as a model in leprosy research...
  7. ncbi Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death
    Helen E Thomas
    St Vincent s Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:20-7. 2006
    ..Blocking NFkappaB has been proposed as a mechanism for protection of beta cells from cytokine-induced cell death in vivo. Our results suggest that this would make beta cells equally or more sensitive to cytokines...
  8. pmc Pro-inflammatory cytokines increase reactive oxygen species through mitochondria and NADPH oxidase in cultured RPE cells
    Dongli Yang
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105 0714, USA
    Exp Eye Res 85:462-72. 2007
    ..05). Collectively, these results demonstrate that TNF-alpha, IL-1 beta and IFN-gamma increase mitochondrial- and NADPH oxidase-generated ROS in human RPE cells...
  9. ncbi Long-term clinical effects of interferon gamma-1b and colchicine in idiopathic pulmonary fibrosis
    K M Antoniou
    Dept of Pneumonology, Medical School, University of Crete, Iraklion, Greece
    Eur Respir J 28:496-504. 2006
    ..These data suggest that long-term treatment with interferon gamma 1b may improve survival and outcome in patients with mild-to-moderate idiopathic pulmonary fibrosis. Further studies are needed to verify these results...
  10. pmc Adjuvant interferon gamma in patients with drug - resistant pulmonary tuberculosis: a pilot study
    Roberto Suárez-Méndez
    Benéfico Jurídico Hospital, Havana, Cuba
    BMC Infect Dis 4:44. 2004
    ..Tuberculosis (TB) is increasing in the world and drug-resistant (DR) disease beckons new treatments...
  11. pmc The proteasome activator 11 S REG (PA28) and class I antigen presentation
    M Rechsteiner
    Department of Biochemistry, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Biochem J 345:1-15. 2000
    ..In the present review we focus on the structural properties of REG molecules and on the evidence that REGalpha/beta functions in the Class I immune response...
  12. pmc Recombinant gamma interferon stimulates signal transduction and gene expression in alveolar macrophages in vitro and in tuberculosis patients
    Rany Condos
    Bellevue Chest Service and Division of Pulmonary and Critical Care Medicine, Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Infect Immun 71:2058-64. 2003
    ..rIFN-gamma aerosol induces signal transduction and gene expression in BAL cells and should be evaluated for efficacy in a randomized, controlled clinical trial...
  13. ncbi Inhibition of nitric oxide and tumor necrosis factor-alpha by moutan cortex in activated mouse peritoneal macrophages
    Hwan Suck Chung
    Purimed R and D Institute, Kyung Hee University, Dongdaemoon gu, Seoul, Korea
    Biol Pharm Bull 30:912-6. 2007
    ..5 mg/ml. These findings demonstrate that the inhibition of the LPS/rIFN-gamma-induced production of NO and TNF-alpha by MC is due to the inhibition of NF-kappaB activation...
  14. ncbi Inhibition of extracellular signal-regulated kinase 1/2 augments nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells
    Naoki Koide
    Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    FEMS Immunol Med Microbiol 45:213-9. 2005
    ..The results suggest that Erk1/2 might negatively regulate NO production in LPS-stimulated RAW264.7 cells...
  15. ncbi Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences
    Robert D Stout
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Health Sciences Center, Louisville, KY 40292, USA
    J Immunol 175:342-9. 2005
    ....
  16. pmc Lung macrophages from bacille Calmette-Guérin-vaccinated guinea pigs suppress T cell proliferation but restrict intracellular growth of M. tuberculosis after recombinant guinea pig interferon-gamma activation
    A Jeevan
    Department of Microbial and Molecular Pathogenesis, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Clin Exp Immunol 149:387-98. 2007
    ..tuberculosis...
  17. pmc Role of endogenous IFN-gamma in macrophage programming induced by IL-12 and IL-18
    Karina R B Bastos
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1730, Sao Paulo, SP, Brazil, CEP 05508 000
    J Interferon Cytokine Res 27:399-410. 2007
    ....
  18. ncbi Nerve growth factor regulates TNF-alpha production in mouse macrophages via MAP kinase activation
    R Barouch
    The Gonda (Goldschmied) Medical Diagnosis Research Center, Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel
    J Leukoc Biol 69:1019-26. 2001
    ..Our results suggest that NGF has an important role in the activation of macrophages during inflammatory responses via activation of mitogen-activated protein kinases...
  19. ncbi Endogenous IFN-alpha beta suppresses colony-stimulating factor (CSF)-1-stimulated macrophage DNA synthesis and mediates inhibitory effects of lipopolysaccharide and TNF-alpha
    J A Hamilton
    Department of Medicine, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia
    J Immunol 156:2553-7. 1996
    ..it is proposed that the type I IFN receptor (IFNAR 1) "knockout" mice may be useful in delineating some of the in vivo actions of CSF-1, LPS, TNF-alpha, and possibly other agents...
  20. ncbi Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages
    Michelino Di Rosa
    Department of Biomedical Sciences, University of Catania, Italy
    Clin Chem Lab Med 43:499-502. 2005
    ..This finding is consistent with the hypothesis that the production of chitotriosidase by macrophages could have biological relevance in the immune response...
  21. ncbi Potentiation of interferon-gamma-stimulated nitric oxide production by retinoic acid in RAW 264.7 cells
    L M Austenaa
    Department of Nutrition, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Leukoc Biol 70:121-9. 2001
    ....
  22. ncbi Signaling pathways initiated in macrophages after engagement of type A scavenger receptors
    S P Coller
    University of Wisconsin Medical School, Madison 53706-1532, USA
    J Leukoc Biol 70:142-8. 2001
    ..The response pattern suggests that tyrosine phosphorylation and activation of the MAP kinase pathway are key components of SR-A-mediated signal transduction cascades...
  23. ncbi Activation-induced depletion of protein kinase C alpha provokes desensitization of monocytes/macrophages in sepsis
    Andreas von Knethen
    Department of Cell Biology, University Kaiserslautern, Kaiserslautern, Germany
    J Immunol 174:4960-5. 2005
    ..We suggest that depletion of PKC alpha in monocytes from septic patients contributes to cellular desensitization, giving rise to clinical symptoms of sepsis...
  24. ncbi Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity
    Yun Seon Song
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P O BOX 131, Cheongryang, 130 650, Seoul, South Korea
    Cancer Lett 175:53-61. 2002
    ....
  25. ncbi Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells
    N Polentarutti
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur Cytokine Netw 8:271-4. 1997
    ..In contrast, IL-4, IL-13 and IL-10 either did not affect or they amplified MCP-3 induction in EC. EC-produced MCP-3 may be important in the regulation of extravasation of receptor-expressing cells, including NK cells and eosinophils...
  26. ncbi PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages
    Kate Schroder
    Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane 4072, Australia
    J Leukoc Biol 81:1577-90. 2007
    ..This study therefore characterizes the regulation of mouse Tlr9 expression and defines a molecular mechanism by which IFN-gamma amplifies mouse macrophage responses to CpG DNA...
  27. ncbi IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells
    Mari Strengell
    Department of Viral Diseases and Immunology, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    J Leukoc Biol 79:1279-85. 2006
    ..Our results demonstrate that IL-21, a cytokine produced by activated T cells, can directly inhibit the activation and cytokine production of myeloid DCs, providing a negative feedback loop between DCs and T lymphocytes...
  28. ncbi IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2
    Sabine Tötemeyer
    Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
    J Immunol 176:4804-10. 2006
    ..This study also shows that the effect of IFN-gamma in restoring inflammatory responses to gram-negative bacteria or bacterial products in mice with defective TLR4 signaling is likely to be due to a response to peptidoglycan, not LPS...
  29. ncbi SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages
    Amy O Hardin
    Children s Foundation Research Center at Le Bonheur Children s Medical Center, Room 301 West Patient Tower, 50 North Dunlap, Memphis, TN 38103, USA
    Biochem Biophys Res Commun 342:547-55. 2006
    ..Taken together, these data provide the first direct evidence that SHP-1 inhibits macrophage activation by LPS and suggest that this effect may be mediated in part by dephosphorylation of vav1...
  30. ncbi Human keratinocytes produce the complement inhibitor factor H: synthesis is regulated by interferon-gamma
    Krisztina K Timár
    Department of Dermatology, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    Mol Immunol 43:317-25. 2006
    ..Factor H released in response to IFN-gamma was functionally active. In conclusion, we demonstrate that keratinocytes are capable of synthesizing factor H and that this synthesis is regulated by IFN-gamma...
  31. ncbi Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1
    A Pellacani
    Cardiovascular and Pulmonary and Critical Care Divisions, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 276:1653-9. 2001
    ..This down-regulation of HMG-I(Y) contributes to the TGF-beta1-mediated decrease in NOS2 gene transactivation by proinflammatory stimuli...
  32. ncbi Novel function of IFN-gamma: negative regulation of dendritic cell migration and T cell priming
    Xiaodong Wu
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences CAS, 320 Yueyang Road, Shanghai 200031, China
    J Immunol 177:934-43. 2006
    ..Taken together, IFN-gamma appears to play a negative regulatory role on in vivo DC function, resulting in suppression of Ag-specific T cell priming...
  33. ncbi The effects of lidocaine on nitric oxide production from an activated murine macrophage cell line
    M Shiga
    Department of Anesthesiology, Kobe University School of Medicine, Kobe, Japan
    Anesth Analg 92:128-33. 2001
    ..The attenuating effect of lidocaine on organ injuries previously reported may be explained by the ability of the drug to suppress this inflammatory mediator...
  34. ncbi Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages is inhibited by lipopolysaccharide
    John Lindbom
    Department of Molecular and Clinical Medicine, Division of Occupational and Environmental Medicine, Faculty of Health Sciences, University of Linkoping, S 581 85 Linkoping, Sweden
    Inflammation 29:108-117. 2005
    ..The possibility that PLA(2) IID is involved in cytokine-mediated inflammation in the nasal mucosa is inferred, as is the potential role of PLA(2) IID in the host defense against LPS-containing bacteria...
  35. pmc Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Exp Med 204:141-52. 2007
    ....
  36. ncbi Upregulation of TNF-alpha production by IFN-gamma and LPS in cultured canine keratinocytes: application to monosaccharides effects
    C Ibisch
    Unit of Dermatology, Clinical Parasitology and Mycology, National Veterinary School, Atlanpole La Chantrerie, BP 40 706, 44 307 Nantes 03, France
    Vet Res Commun 31:835-46. 2007
    ..In this study, cultured canine keratinocytes were stimulated by human recombinant interferon gamma (IFN-gamma) and lipopolysaccharide (LPS) and cell supernatants were tested for tumour necrosis factor ..
  37. ncbi Xanthii fructus inhibits inflammatory responses in LPS-stimulated mouse peritoneal macrophages
    Hyo Jin An
    College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea
    Inflammation 28:263-70. 2004
    ..However, treatment of XF in peritoneal macrophages had no effect on IL-12p40 production. These findings suggest that XF may be used in controlling macrophages-mediated inflammatory diseases...
  38. ncbi IFN-gamma prevents TNF-alpha-induced apoptosis in C2C12 myotubes through down-regulation of TNF-R2 and increased NF-kappaB activity
    Laia Tolosa
    Institut Universitari d Investigacions en Ciències de la Salut Departament de Biologia, Universitat de les Illes Balears, E 07122 Palma de Mallorca, Spain
    Cell Signal 17:1333-42. 2005
    ..Together, these results demonstrate that TNF-alpha directly induces apoptosis in differentiated myotubes and suggest that the cytokine IFN-gamma, might represent a new immunoadjuvant therapeutic tool for managing cachexia...
  39. ncbi Bacterial LPS and IFN-gamma trigger the tyrosine phosphorylation of vav in macrophages: evidence for involvement of the hck tyrosine kinase
    B K English
    Crippled Children s Foundation Research Center at Le Bonheur Children s Medical Center, Department of Pediatrics, University of Tennessee Memphis, 38103, USA
    J Leukoc Biol 62:859-64. 1997
    ..These findings suggest that hck probably mediates vav tyrosine phosphorylation during macrophage activation and that LPS and rIFN-gamma-mediated signaling pathways partially overlap...
  40. ncbi Protein kinase C independent activation of inducible nitric oxide synthase by tumor necrosis factor-alpha in TM4 Sertoli cells
    C K Chung
    Department of Food and Nutrition, Hallym University, Chunchon, South Korea
    Immunopharmacol Immunotoxicol 22:49-59. 2000
    ..These results suggest that the role of TNF-alpha is to provide TM4 Sertoli cells with the active cofactor for NO production and TNF-alpha-induced signaling for induction of NO synthesis is not dependent on protein kinase C activation...
  41. pmc Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes
    D A Geller
    Department of Surgery, University of Pittsburgh, PA 15261
    Proc Natl Acad Sci U S A 90:3491-5. 1993
    ..hep-NOS appears to be an inducible form of NOS that is distinct from mac-NOS as well as brain and endothelial NOS isozymes...
  42. ncbi Differential regulation of resveratrol on lipopolysacchride-stimulated human macrophages with or without IFN-gamma pre-priming
    Yong hong Feng
    State Key Lab of Drug Research, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences Shanghai 201203, PR China
    Int Immunopharmacol 4:713-20. 2004
    ..The differential impact of resveratrol on expression of CD14 might be correlated with differential response of macrophages to LPS with or without IFN-gamma priming...
  43. pmc Tumor necrosis factor alpha augments nitric oxide-dependent macrophage cytotoxicity against Entamoeba histolytica by enhanced expression of the nitric oxide synthase gene
    J Y Lin
    Institute of Parasitology of McGill University, Ste Anne de Bellevue, Quebec, Canada
    Infect Immun 62:1534-41. 1994
    ..Taken together, these data argue that TNF-alpha augments NO-dependent macrophage cytotoxicity against E. histolytica via elevated levels of mac-NOS mRNA expression which may be associated with the accumulation of TNF-alpha mRNA...
  44. ncbi Prolactin-cytokine network in the defence against Acanthamoeba castellanii in murine microglia [corrected]
    Nunzia Benedetto
    Institute of Microbiology, Faculty of Medicine and Surgery, Second University of the Studies of Naples, Italy
    Eur Cytokine Netw 13:447-55. 2002
    ..castellanii infection in the brain [corrected]...
  45. pmc Normal and SV40 transfected human peritoneal mesothelial cells produce IL-6 and IL-8: implication for gynaecological disease
    X Y Zhang
    Department of Obstetrics and Gynaecology, St George s Hospital Medical School, London, UK
    Clin Exp Immunol 129:288-96. 2002
    ....
  46. pmc Nitrogen monoxide-mediated control of ferritin synthesis: implications for macrophage iron homeostasis
    Sangwon Kim
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and Department of Physiology, McGill University, 3755 Cote Sainte Catherine Road, Montreal, QC, Canada H3T 1E2
    Proc Natl Acad Sci U S A 99:12214-9. 2002
    ..These observations indicate that NO+-mediated modulation of IRP2 plays an important role in controlling ferritin synthesis and iron metabolism in murine macrophages...
  47. ncbi Anti-allergic agents from natural sources (4): anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae)
    Akihiro Daikonya
    College of Pharmacy, Nihon University, Chiba, Japan
    Chem Pharm Bull (Tokyo) 50:1566-9. 2002
    ..Furthermore, they inhibited histamine release from rat peritoneal mast cells induced by Compound 48/80. These results suggest that the novel phloroglucinol derivatives have anti-inflammatory effects...
  48. pmc Protective effect of exogenous recombinant mouse interferon-gamma and tumour necrosis factor-alpha on ectromelia virus infection in susceptible BALB/c mice
    A V Atrasheuskaya
    State Research Center of Virology and Biotechnology Vector, Koltsovo, Russia
    Clin Exp Immunol 136:207-14. 2004
    ..The successful cytokine treatment schemes in this orthopoxvirus model system may have important implications in the treatment of viral diseases in humans and, in particular, of variola virus infection...
  49. ncbi Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells
    G Werner-Felmayer
    Department of Medical Chemistry and Biochemistry, University of Innsbruck, Austria
    Biol Chem Hoppe Seyler 370:1063-9. 1989
    ..Lipopolysaccharide directly affected macrophages or dermal fibroblasts and enhanced the effect of interferon-gamma. However, in the presence of lymphocytes, the action of lipopolysaccharide was mediated via interferon-gamma...
  50. ncbi Effect of bismuth subgallate on nitric oxide and prostaglandin E2 production by macrophages
    Chia Yen Lin
    Institute of Biochemistry, School of Life Science, National Yang Ming University, 155, Li Nong St, Sec 2, Peitou, Taipei, Taiwan, ROC
    Biochem Biophys Res Commun 315:830-5. 2004
    ..7 cells. Exogenous addition of SNP reversed the inhibition effect of PGE2 production by BSG. This behavior indicates that PGE2 inhibition by BSG exerts an indirect effect through NO inhibition...
  51. pmc Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains
    E M E Burudi
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:12233-41. 2002
    ..In vitro studies on mouse microglia reveal that IFN-gamma is the primary inducer of IDO expression. These findings demonstrate the link between IDO expression, IFN-gamma levels, and brain pathology signs observed in neuro-AIDS...
  52. ncbi NRAMP1- or cytokine-induced bacteriostasis of Mycobacterium avium by mouse macrophages is independent of the respiratory burst
    M Salomé Gomes
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre, 823, Portugal
    Microbiology 148:3155-60. 2002
    ..Reactive oxygen species are therefore not involved in the constitutive or induced anti-M. avium activities of the mouse macrophage...
  53. ncbi Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
    M P Hayes
    Division of Cytokine Biology, Food and Drug Administration, Bethesda, MD 20892, USA
    Blood 86:646-50. 1995
    ..The selectivity of priming by IFN-gamma is in accord with a putative role for IL-12 in the initiation and amplification of TH1-type responses...
  54. ncbi Active and inactive influenza virus induction of tumor necrosis factor-alpha and nitric oxide in J774.1 murine macrophages: modulation by interferon-gamma and failure to induce apoptosis
    Leslie C McKinney
    Radiation Pathophysiology and Toxicology Department, Armed Forces Radiobiology Research Institute, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA
    Virus Res 97:117-26. 2003
    ..Importantly, viral replication was not required for the induction of TNF-alpha or NO, and the action of inactive IAV could be potentiated by IFN-gamma...
  55. pmc A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines
    J M Farber
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 87:5238-42. 1990
    ..It is proposed that the gene encoding this protein be called mig, for monokine induced by gamma interferon...
  56. ncbi TNF-mediated IL6 gene expression and cytotoxicity are co-inducible in TNF-resistant L929 cells
    V Vandevoorde
    Laboratory of Molecular Biology, Gent University, Belgium
    FEBS Lett 302:235-8. 1992
    ..These results confirm our earlier conclusions regarding the close relationship between TNF-mediated IL6 gene expression and the pathway leading to cytotoxicity...
  57. ncbi Ultra-wideband pulses increase nitric oxide production by RAW 264.7 macrophages incubated in nitrate
    Ronald L Seaman
    McKessonHBOC Clinical and Biological Services, Microwave Bioeffects Branch, U S Army Medical Research Detachment, Brooks AFB, Texas 78235 5460, USA
    Bioelectromagnetics 23:83-7. 2002
    ..However, when nitrate was added to the medium of stimulated cells, nitric oxide production increased after UWB exposure, indicating a possible action of UWB pulses on induced nitric oxide synthase under certain conditions...
  58. ncbi Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages
    J Wang
    Food Research Program, Pacific Agri Food Research Centre, Agriculture and Agri Food Canada, Summerland, British Columbia, Canada
    J Agric Food Chem 50:850-7. 2002
    ..This is the first study to report the inhibitory effects of anthocyanins and berry phenolic compounds on NO production...
  59. ncbi Impaired macrophage responses may contribute to exacerbation of blood-stage Plasmodium chabaudi chabaudi malaria in interleukin-12-deficient mice
    Karina R B Bastos
    Departamento de Imunologia, Instituto de Ciencias Biomedicas, Av Prof Lineu Prestes 1730, Universidade de Sao Paulo, Sao Paulo, SP Brazil CEP 05508 900
    J Interferon Cytokine Res 22:1191-9. 2002
    ..c. chabaudi malaria...
  60. ncbi Inducible accessory function of a macrophage cell line
    F B Aiello
    Biological Carcinogenesis and Development Program, Program Resources Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, MD
    Immunopharmacol Immunotoxicol 15:327-53. 1993
    ..The expression of ICAM-1 and LFA-1 was increased during activation and anti-LFA-1 antibody blocked APC function. This suggests that one important feature of the activation process may be improvement of cellular adhesion...
  61. ncbi Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide-mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia
    Hee Sun Kim
    Department of Neuroscience, Ewha Institute of Neuroscience and Medical Research Center, College of Medicine, Ewha Woman s University, Seoul, South Korea
    J Neuroimmunol 151:85-93. 2004
    ..Thus, the specific down-regulation of IFN-gamma-induced microglial activation by sodium butyrate may provide potential therapeutic strategies for a variety of inflammatory diseases in the central nervous system...
  62. ncbi Detection and analysis of the 80-kd lipopolysaccharide receptor in macrophages derived from Lpsn and Lpsd mice
    P Y Perera
    Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814
    J Leukoc Biol 51:501-6. 1992
    ....
  63. ncbi Traces of bacterial lipopolysaccharide suppress IFN-gamma-induced nitric oxide synthase gene expression in primary mouse macrophages
    C Bogdan
    Beatrice and Samuel A Seaver Laboratory, Department of Medicine, Cornell University Medical College, New York, NY 10021
    J Immunol 151:301-9. 1993
    ..Regulation of iNOS in vivo may depend on the relative tempo with which the inflammatory and immune responses evolve...
  64. ncbi TNF-alpha mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis
    Simone G Fonseca
    Department of Biochemistry and Immunology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Eur J Immunol 33:2297-306. 2003
    ..Consequently, these results suggest that neutrophils do not respond to anti-TNF-alpha treatment and might be a source of NO to control L. major infection under these experimental conditions...
  65. pmc Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells
    Michael J Eppihimer
    Discovery Research Respiratory Diseases, Wyeth Genetics Institute, Andover, MA 01810, USA
    Microcirculation 9:133-45. 2002
    ..To evaluate the expression and regulation of a novel B7-like protein, PD-L1, the ligand for the immunoinhibitory receptor PD-1 expressed on activated T-cells, on microvascular endothelial cells (ECs)..
  66. ncbi Pro-inflammatory cytokines up-regulate MUC1 gene expression in oral epithelial cells
    X Li
    Department of Periodontology and Oral Biology, Boston University Medical Center, MA 02118, USA
    J Dent Res 82:883-7. 2003
    ..85-fold increase in MUC1 transcript levels. These results suggest that increased MUC1 synthesis may be a key element in the host response to infection with oral pathogens...
  67. pmc Role of interferon-gamma in T-cell responses to Semliki Forest virus-infected murine brain cells
    P T Tomkins
    Department of Biological Sciences, University of Warwick, Coventry, U K
    Immunology 63:355-62. 1988
    ..IFN-gamma released by T cells stimulated with BPL-SFV-treated brain cells increased class II MHC expression by brain cells as assessed by indirect immunofluorescence...
  68. pmc Efficacy of recombinant gamma interferon for treatment of systemic cryptococcosis in SCID mice
    K V Clemons
    Department of Medicine, Division of Infectious Diseases, Santa Clara Valley Medical Center, San Jose, California 95128, USA
    Antimicrob Agents Chemother 45:686-9. 2001
    ..Significant synergistic activity was noted in all organs except the spleen. Overall, IFN-gamma has utility as an adjunctive therapy against systemic cryptococcosis in the severely immunocompromised host...
  69. pmc Cytokine-mediated activation of macrophages from Mycobacterium bovis BCG-resistant and -susceptible mice: differential effects of corticosterone on antimycobacterial activity and expression of the Bcg gene (Candidate Nramp)
    D H Brown
    Department of Microbiology, Ohio State University, Columbus 43210, USA
    Infect Immun 63:2983-8. 1995
    ..avium by macrophages from both Bcgr and Bcgs mice. The addition of corticosterone suppressed Nramp expression by macrophages from Bcgs mice. Nramp expression by macrophages from Bcgr mice was not affected by corticosterone...
  70. ncbi Characterization of three neutral proteases of Spirometra mansoni plerocercoid
    Y Kong
    Department of Parasitology, College of Medicine, Chung Ang University, Seoul, Korea
    Parasitology 108:359-68. 1994
    ..The 36 kDa enzyme cleaved human recombinant interferon-gamma (rIFN gamma) and bovine myelin basic protein. In addition, all the purified proteins elicited strong antibody responses in the infected patients...
  71. pmc Evidence of cell-mediated immune contrasuppression in lepromatous leprosy: modulation of a putative T contrasuppressor cell-subset
    R Gonzalez-Amaro
    Department of Immunology, School of Medicine, University of San Luis Potosi, Mexico
    Clin Exp Immunol 71:399-404. 1988
    ..These data suggest that the in vitro immune response to M. leprae in some LL patients can be augmented by either modifying numerically the contrasuppressor T cells or activating them with lymphokines...
  72. ncbi Cow's milk protein induced changes in the expression of HLA-DR antigens on colonic epithelial cells
    Hai Lee Chung
    Department of Pediatrics, School of Medicine, Catholic University of Taegu, Taegu, Korea
    Ann Allergy Asthma Immunol 90:348-50. 2003
    ..Normal colonic epithelial cells do not express HLA-DR antigens unless they become inflamed. It is possible that colonic epithelial cells may function as antigen-presenting cells once HLA-DR is induced by infection or inflammation...
  73. ncbi Effect of the combined treatment with 5-fluorouracil, gamma-interferon or folinic acid on carcinoembryonic antigen expression in colon cancer cells
    A Aquino
    Department of Neuroscience, University of Rome, Tor Vergata, Italy
    Clin Cancer Res 4:2473-81. 1998
    ..These results could be of potential diagnostic and/or therapeutic value when CEA protein is the target of humoral or cell-mediated immunity...
  74. ncbi The nitric oxide-producing activities of Scutellaria baicalensis
    H M Kim
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea
    Toxicology 135:109-15. 1999
    ..All the preparations of SB were endotoxin free. These results suggest that the capacity of SB to increase NO production from rIFN-gamma-primed mouse peritoneal macrophages is the result of SB-induced TNF-gamma secretion...
  75. pmc The Golgi CMP-sialic acid transporter: A new CHO mutant provides functional insights
    Sing Fee Lim
    Bioprocessing Technology Institute, Agency for Science, Technology and Research, Centros, Singapore
    Glycobiology 18:851-60. 2008
    ..The CMP-SAT only lost partial activity if the same Gly residues were substituted with Ala, suggesting that the lack of side chain in Gly residues in the transmembrane domains is essential for transport activity...
  76. ncbi [Obtaining antibodies and development of an immunoassay for the detection of Escherichia coli proteins in preparations of human recombinant gamma interferon]
    N Diaz
    Departamento de Inmunoquimica, Centro de Ingenieria Genetica y Biotecnologia, La Habana, Cuba
    Rev Argent Microbiol 30:64-72. 1998
    ..The detection limit of that system was 3.125 ng/mL and the quantification limit 6.25 ng/mL...
  77. ncbi Activation of inducible nitric oxide synthase by Taraxacum officinale in mouse peritoneal macrophages
    H M Kim
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea
    Gen Pharmacol 32:683-8. 1999
    ..All the preparations of TO were endotoxin free. These results suggest that the capacity of TO to increase NO production from rIFN-gamma-primed mouse peritoneal macrophages is the result of TO-induced TNF-alpha secretion...
  78. ncbi Patterns of cytokine induction by gram-positive and gram-negative probiotic bacteria
    Martin L Cross
    Human Nutrition and Health Research Group, Institute of Food, Nutrition and Human Health, Massey University, Riddet Building, Level 2, Palmerston North, New Zealand
    FEMS Immunol Med Microbiol 42:173-80. 2004
    ....
  79. ncbi Production of nitric oxide in mouse peritoneal macrophages after priming with interferon-gamma by the stem of Sinomenium acutum
    H M Kim
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea
    J Ethnopharmacol 66:311-7. 1999
    ..the aqueous extract of Sinomenium acutum stem (SSAE) produces nitric oxide (NO) upon treatment with recombinant interferon gamma (rIFN-gamma) in mouse peritoneal macrophages. Apparently SSAE has no effect on NO production by itself...
  80. ncbi Treatment of recurrent sarcoma of the extremities by isolated limb perfusion using tumor necrosis factor alpha and melphalan
    M Santinami
    Division of Surgical Oncology B, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 82:579-84. 1996
    ..5 degrees C) with rHu TNF-alpha and melphalan. Two patients also received recombinant interferon gamma (rIFN-gamma) before and during ILP...
  81. ncbi Activation of inducible nitric oxide synthase by Euonymus alatus in mouse peritoneal macrophages
    Hwan Suck Chung
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk 570 749, South Korea
    Clin Chim Acta 318:113-20. 2002
    ..However, it is still unclear how this herb prevents the diseases in experimental models. Nitric oxide (NO) as a potent macrophage-derived effector molecule against a variety of tumors has received increasing attention...
  82. pmc Structural equation model testing and the quality of natural killer cell activity measurements
    Leslie A Hayduk
    Department of Sociology, University of Alberta, Edmonton, Alberta, T6G 2H4 Canada
    BMC Med Res Methodol 5:1. 2005
    ....
  83. ncbi Process monitoring of the production of gamma-interferon in recombinant Chinese hamster ovary cells
    T K Nadler
    Chemistry Department, Purdue University, West Lafayette, IN 47907
    J Chromatogr A 659:317-20. 1994
    ..Results indicated that the production of each form was coincidental and that the glycosylated form of gamma-interferon is produced in greater abundance than non-glycosylated...
  84. ncbi Methionine-enkephalin primes human neutrophils for enhanced superoxide anion production
    H Haberstock
    Department of Experimental Biology and Medicine, Laboratory for Biological Response Modifiers, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 19:135-45. 1997
    ..stimulated by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) or human recombinant interferon gamma (hrIFN gamma) when the cells had been preincubated with MENK for 30 min at 37 degrees C...
  85. pmc Survival of group B streptococcus type III in mononuclear phagocytes: differential regulation of bacterial killing in cord macrophages by human recombinant gamma interferon and granulocyte-macrophage colony-stimulating factor
    L Marodi
    Department of Infectology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Infect Immun 68:2167-70. 2000
    ..These data indicate differential modulation of neonatal macrophages by rhGM-CSF and rhIFN-gamma. We suggest that administration of rhGM-CSF to neonates with invasive GBS disease may enhance host resistance to these bacteria...
  86. pmc Down-regulation of transforming growth factor-beta gene expression by antisense oligodeoxynucleotides increases recombinant interferon-gamma-induced nitric oxide synthesis in murine peritoneal macrophages
    C D Jun
    Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iri Chonbuk, Korea
    Immunology 85:114-9. 1995
    ....
  87. ncbi Activation of inducible nitric oxide synthase by Kagamjuaguiem in peritoneal macrophages in mice
    Hyo Jin An
    College of Oriental Medicine, Institute of Oriental Medicine, Oriental Medical Science Center, Kyung Hee University, Seoul, Korea
    Indian J Med Res 125:740-6. 2007
    ..In this study, using mouse peritoneal macrophages, we have examined the mechanism by which KJE regulates NO production...
  88. ncbi Role of C5a in the induction of tumoricidal activity in C3H/HeJ (Lpsd) and C3H/OuJ (Lpsn) macrophages
    M M Hogan
    Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland
    J Leukoc Biol 46:565-70. 1989
    ....
  89. ncbi [Application of immune function test to evaluate effect of cytokine-induced autologous killer cell infusion for elderly patients with hematological malignancies]
    Li Li Cai
    Department of Geriatric Laboratory Medicine, Institute of Basic Medical Sciences, Chinese PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1250-5. 2010
    ..from 20 elderly patients with hematological malignancies, and then augmented by priming with human recombinant interferon gamma (rhIFN-γ) followed by human recombinant interleukin 2 (rhIL-2) and monoclonal antibody (mAb) against ..
  90. pmc Recombinant gamma interferon provokes resistance of human breast cancer cells to spontaneous and IL-2 activated non-MHC restricted cytotoxicity
    N Jabrane Ferrat
    Laboratoire de Pharmacologie, , France
    Br J Cancer 61:558-62. 1990
    ..The therapeutic use of monoclonal antibodies directed against antigens expressed on tumour cells (ADCC) in conjunction with interferon therapy should be discussed in lymphokine-based strategies for treatment of cancer patients...
  91. pmc Recent advances in management of cryptococcal meningitis: commentary
    Tania C Sorrell
    Centre for Infectious Diseases and Microbiology and the University of Sydney at Westmead Hospital Darcy Road, Westmead, NSW 2145 Australia
    F1000 Med Rep 2:82. 2010
    ..Clinicians should be vigilant for immune restoration-like features. Adjuvant surgery, corticosteroids, and/or recombinant interferon-gamma may be required for large cryptococcomas, cerebral edema, or refractory infection...
  92. ncbi The effects of inhaled interferon gamma in normal human airways
    R J Martin
    Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Am Rev Respir Dis 148:1677-82. 1993
    ..We conclude that, in normal persons, rIFN-gamma can be effectively delivered by inhalation. Future trials using inhaled rIFN-gamma appear to be warranted for certain pulmonary diseases...
  93. ncbi Induction of nitric oxide & tumour necrosis factor-alpha by Psoralea corylifolia
    Hyo Jin An
    College of Oriental Medicine, Institute of Oriental Medicine, Oriental Medical Science Center, Kyung Hee University, Seoul, Republic of Korea
    Indian J Med Res 128:752-8. 2008
    ..In the present study we investigated effect of PC on nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production in mouse peritoneal macrophages and also examined the mechanism by which PC regulates NO production...
  94. ncbi Expression of properdin in human monocytes
    W Schwaeble
    Department of Immunology, University of Leicester, England
    Eur J Biochem 219:759-64. 1994
    ..The data suggest that the expression and secretion of this complement regulatory protein by monocytes is differentially regulated by cytokines and link the immune response with alternative pathway activation...
  95. ncbi Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008
    ..Yet, this condition can be reverted by reactivating the pathway downstream of the superoxide-dependent step...
  96. ncbi Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo
    Naoki Iwamoto
    Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Liver Int 29:277-83. 2009
    ..The present study aimed to determine IDO expression in the liver and hepatocytes during an acute hepatitis model...
  97. ncbi Recombinant interferon gamma treatment in non-small cell lung cancer. Antitumour effect and cardiotoxicity
    K Mattson
    Department of Pulmonary Medicine, Helsinki University Central Hospital, Finland
    Acta Oncol 30:607-10. 1991
    ..Our results suggest that high dose r-IFN-gamma might have some biological activity in NSCLC and does not interfere with subsequent conventional therapies given with a curative intent...
  98. ncbi Molecular assessment of the potential combination therapy of cytokines with biphalin and AZT for Friend leukemia virus infection in vitro
    Jie Liu Tang
    Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, 12901 N Bruce B Downs Blvd, Tampa, FL 33612, USA
    Pharmacol Rep 60:190-8. 2008
    ..Under cell-free conditions, recombinant interferon gamma (IFNgamma), interleukin 2 (IL-2) and IL-4 directly inhibited the FLV reverse transcriptase (RT) ..
  99. pmc Role of methionine sulfoxide reductases A and B of Enterococcus faecalis in oxidative stress and virulence
    Chen Zhao
    Laboratoire de Microbiologie de l Environnement Université de Caen, EA956 USC INRA2017, 14032 Caen Cedex, France
    Infect Immun 78:3889-97. 2010
    ..Virulence was reconstituted in the complemented strains. The combined results show that Msr repair enzymes are important for the oxidative stress response, macrophage survival, and persistent infection with E. faecalis...
  100. ncbi Invasive aspergillosis in chronic granulomatous disease
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Med Mycol 47:S282-90. 2009
    ....
  101. ncbi Alternative and/or integrative therapies for pneumonia under development
    Mario Cazzola
    A Cardarelli Hospital, Department of Respiratory Medicine, Unit of Pneumology and Allergology, Naples, Italy
    Curr Opin Pulm Med 10:204-10. 2004
    ..Interfering with bacterial adhesion, inhibiting, neutralizing and clearing endotoxin, and administering cytokines as immunoadjuvants are the most promising alternative or integrative treatments for pneumonia that are under development...

Research Grants43

  1. WHITE BLOOD CELL OXIDASE IN LEUKEMIA AND NORMAL CELLS
    Peter Newburger; Fiscal Year: 1991
    ..These studies will determine the effects of human recombinant interferon gamma, tumor necrosis factor, and granulocytes-macrophage colony- stimulating factor on X-CGD transcript ..
  2. INDOLEAMINE 2,3-DIOXYGENASE IN OPPORTUNISTIC INFECTIONS
    SOHAN GUPTA; Fiscal Year: 1992
    ..Elucidation of the role of IDO in blocking T gondii replication will provide not only host defense mechanism but also new concept for developing effective drugs for prevention and treatment of toxoplasmosis in AIDS patients...
  3. MOLECULAR BASIS OF INTERFERON ACTION--RELATION TO M.S.
    Richard Ransohoff; Fiscal Year: 1992
    ..We will then clarify whether Ia expression on human astrocytes can e inhibited by other interferons or prostaglandins. These experiments will address issues of fundamental and clinical relevance in intrathecal immune responses...
  4. OPTIMIZATION OF MONOCLONAL ANTIBODY LOCALIZATION
    James Murray; Fiscal Year: 1991
    ..The data derived from these studies should have direct bearing on clinical use of MoAb in human patients...
  5. Role of LRP in Astrocytoma Migration
    Isa Hussaini; Fiscal Year: 2007
    ..Understanding the role of LRP in the migration and invasion astrocytic tumors will provide information on possible specific targets for therapeutic intervention. [unreadable] [unreadable]..
  6. Macrophage Dysfunction in Immunosenescence
    Robert Stout; Fiscal Year: 2006
    ....
  7. Induction of suppression for Islet Transplantation
    Zandong Yang; Fiscal Year: 2003
    ..This study will provide an experimental strategy of using AAV vlL-10 gene therapy to investigate immunosuppression induction in islet transplantation. ..
  8. Tumor Induced Dysregulation of T Cell Immunity
    James H Finke; Fiscal Year: 2010
    ..We will also define the sequence of events leading to T cell death, including the role of iron and lysosomes in this process (aim 3) ..
  9. STROMELYSIN 3 AND THE TUMOR MICROENVIRONMENT
    Margaret Shipp; Fiscal Year: 2002
    ....
  10. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..Determine whether the T reg cells are antigen specific (virus), cardiovascular specific (autoimmunity), or non-antigen specific. ..
  11. The influence of age on CD4 helper activity
    Laura Haynes; Fiscal Year: 2006
    ..abstract_text> ..
  12. Raft/Caveolar Mechanisms in Pulmonary Hypertension
    PRAVIN SEHGAL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  13. DISRUPTION OF PDGF SIGNAL TRANSDUCTION IN LUNG FIBROSIS
    Joseph Lasky; Fiscal Year: 2006
    ..abstract_text> ..
  14. Pediatric Clinical Trials Program for AIDS
    William Shearer; Fiscal Year: 2006
    ..g., Cardiovascular Complications of HIV Infection]) with over 1OO participating professionals give BCM the potential to exceed its past strong role in carrying out the scientific agenda of the PACTG. ..
  15. CTGF IN LUNG FIBROGENESIS
    Joseph Lasky; Fiscal Year: 2004
    ..These studies will establish the role that CTGF plays in lung fibrogenesis. ..
  16. The impact of aging on the inflammatory response
    Robert Stout; Fiscal Year: 2007
    ..Even transient improvement in inflammatory response will not only enhance microbial clearance and wound healing, but likely will also enhance the efficacy of vaccination against infectious disease. [unreadable] [unreadable] [unreadable]..
  17. Role of Eotaxin-3/CCL26 in Allergic Asthma
    Lisa Miller; Fiscal Year: 2008
    ..The identification of chemokines that promote allergic asthma is an important step in the future development of therapeutics to target specific molecules within the airways. [unreadable] [unreadable] [unreadable]..
  18. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  19. Macrophage defense againt M. tuberculosis
    Jennifer Wang; Fiscal Year: 2008
    ..abstract_text> ..
  20. Sleep Studies in HIV+ Older Children/Adolescents
    William Shearer; Fiscal Year: 2007
    ....
  21. Role of EBV gene products in lung fibrogenesis
    Joseph Lasky; Fiscal Year: 2009
    ..There are currently no proven medicinal therapies for the treatment of IPF. Defining the mechanisms through which EBV gene products promote IPF will provide new options for the treatment of this fatal disease. ..
  22. Viral Protein Mediators of HIV-Related Pulmonary Hypertension
    Joseph Lasky; Fiscal Year: 2009
    ....
  23. MACROPHAGE ACTIVATION IN AFRICAN TRYPANOSOMIASIS
    DONNA PAULNOCK; Fiscal Year: 2006
    ..The ultimate goal is to uncover novel regulatory mechanisms associated with macrophage activation that can be exploited to provide greater resistance to disease. ..
  24. NRAMP--MYCOBACTERIAL RESISTANCE, MRNA STABILITY AND IRON
    BRUCE ZWILLING; Fiscal Year: 2001
    ....
  25. CATECHOLAMINE REGULATION OF MACROPHAGE FUNCTION
    BRUCE ZWILLING; Fiscal Year: 2002
    ....
  26. CELLULAR PHYSIOLOGY OF STAT3
    PRAVIN SEHGAL; Fiscal Year: 2002
    ..Establishing the basic subunit structure of the cytosolic 200-400 kDa and 1-2 MDa STAT3-containing complexes in IL-6-free and IL-6-treated cells is a sine qua non for further progress in this field. ..
  27. ROLE OF CATHEPSINS S, L AND B IN THE TYPE 1 DIABETES
    Alexander Rudensky; Fiscal Year: 2003
    ..This work will contribute to our understanding of the role of cathepsins in MHC class II antigen presentation, and provide new targets for downmodulating the immune responses leading to Type 1 diabetes. ..
  28. REGULATION OF NRAMP1 MEDIATED IRON TRANSPORT
    BRUCE ZWILLING; Fiscal Year: 2004
    ..To determine if iron transport by Nramp1 requires protein phosphorylation and 3. To determine, by site directed mutagenesis, the domains within the Nramp1 protein that affect iron transport. ..
  29. Repression of Oral Virus by Interferon & Nuclear Bodies
    Jerry Taylor; Fiscal Year: 2004
    ..This understanding should allow the development of strategies for treatment of secondary viral infections in the oral cavity of HIV-infected individuals that enhance or mimic these repressive activities. ..
  30. Innate Corneal Cell Immunity to Virus Infection
    Jerry Taylor; Fiscal Year: 2004
    ..This knowledge may be utilized to enhance this innate antiviral response and thereby limit initial and recurrent viral infections in the eye. ..
  31. PSYCHOLOGICAL INTERVENTION FOR WOMEN WITH BREAST CANCER
    BARBARA ANDERSEN; Fiscal Year: 2005
    ....
  32. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  33. Aging and Immunity Workshop
    Laura Haynes; Fiscal Year: 2004
    ..In this proposal, we are specifically requesting funds to cover the basic costs to allow five junior investigators to attend the workshop, with the goal of fostering the next generation of immunologists in this field. ..
  34. T CELL UNRESPONSIVENESS IN HUMAN TUMORS
    James Finke; Fiscal Year: 2007
    ..This will involve defining the effect that sensitizing gangliosides have on mitochondrial stability. A better understanding of immune dysfunction may lead to ways in which to improve anti-tumor immunity. ..
  35. Modulation of innate immunity by microbial factors
    DONNA PAULNOCK; Fiscal Year: 2006
    ..The ultimate goal is to uncover novel regulatory mechanisms associated with macrophage activation that can be exploited to provide greater resistance to disease. ..
  36. Early Immune Events in Childhood Asthma
    Lisa Miller; Fiscal Year: 2009
    ..abstract_text> ..
  37. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  38. NFKB DEFECT AND APOPTOSIS IN T CELLS OF CANCER PATIENTS
    James Finke; Fiscal Year: 2003
    ..This assessment will also involve an analysis of select anti-apoptotic genes. These studies should assess whether the defect in NFkappaB and AICD sensitivity are linked and relate to patient outcome. ..
  39. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  40. Colorectal Screening Capacity Building Conference
    David Alberts; Fiscal Year: 2003
    ..Continued capacity building and future collaboration will also be woven into this conference to serve as a stone to build upon in the future. ..
  41. Transplant Associated Infection Surveillance Network
    Peter Pappas; Fiscal Year: 2008
    ..Finally, the establishment of a bank will be invaluable in the development and validation of newer diagnostic assays. ..
  42. Ganglioside Regulation of NFkbeta and Apoptosis
    James Finke; Fiscal Year: 2005
    ..These studies will provide insight into how gangliosides inhibit NFKB and survival gene expression, leading to increased T cell sensitivity to apoptosis. ..