fibroblast growth factor receptors

Summary

Summary: Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.

Top Publications

  1. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
  2. pmc Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
    E Arman
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel 76100, USA
    Proc Natl Acad Sci U S A 95:5082-7. 1998
  3. ncbi Cellular signaling by fibroblast growth factor receptors
    V P Eswarakumar
    Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, P O Box 208066, SHM B 295, New Haven, CT 06520, USA
    Cytokine Growth Factor Rev 16:139-49. 2005
  4. ncbi FGFs, heparan sulfate and FGFRs: complex interactions essential for development
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Bioessays 22:108-12. 2000
  5. ncbi Craniosynostosis: genes and mechanisms
    A O Wilkie
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Hum Mol Genet 6:1647-56. 1997
  6. pmc Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud
    Haotian Zhao
    Center for Human and Molecular Genetics, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    Dev Biol 276:403-15. 2004
  7. ncbi Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    J H Jang
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cancer Res 61:3541-3. 2001
  8. ncbi Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development
    Catharine A Hellingman
    Department of Otorhinolaryngology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Tissue Eng Part A 16:545-56. 2010
  9. ncbi Fibroblast growth factors, their receptors and signaling
    C J Powers
    School of Nursing, Department of Pharmacology, Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Endocr Relat Cancer 7:165-97. 2000
  10. ncbi Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain
    Jonna Saarimäki-Vire
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 27:8581-92. 2007

Research Grants

Detail Information

Publications346 found, 100 shown here

  1. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
    ..These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways...
  2. pmc Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development
    E Arman
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel 76100, USA
    Proc Natl Acad Sci U S A 95:5082-7. 1998
    ..The role of early FGF signaling in pregastrulation development as a possible adaptation to mammalian (amniote) embryogenesis is discussed...
  3. ncbi Cellular signaling by fibroblast growth factor receptors
    V P Eswarakumar
    Yale University School of Medicine, Department of Pharmacology, 333 Cedar Street, P O Box 208066, SHM B 295, New Haven, CT 06520, USA
    Cytokine Growth Factor Rev 16:139-49. 2005
    ....
  4. ncbi FGFs, heparan sulfate and FGFRs: complex interactions essential for development
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Bioessays 22:108-12. 2000
    ..The establishment of a role for heparan sulfate in FGFR activation in vivo suggests that tissue-specific differences in the structure of heparan may modulate the activity of FGF. BioEssays 22:108-112, 2000...
  5. ncbi Craniosynostosis: genes and mechanisms
    A O Wilkie
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Hum Mol Genet 6:1647-56. 1997
    ....
  6. pmc Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud
    Haotian Zhao
    Center for Human and Molecular Genetics, Columbus Children s Research Institute, 700 Children s Drive, Columbus, OH 43205, USA
    Dev Biol 276:403-15. 2004
    ..In conclusion, FGFR2, but not FGFR1, appears crucial for ureteric bud branching morphogenesis and stromal mesenchyme patterning...
  7. ncbi Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    J H Jang
    Laboratory of Cell Biology, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110 744, Korea
    Cancer Res 61:3541-3. 2001
    ..Our results indicate that FGFR2 and FGFR3, in addition to their potential role in skeletal dysplasias, play an important role in tumorigenesis...
  8. ncbi Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development
    Catharine A Hellingman
    Department of Otorhinolaryngology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Tissue Eng Part A 16:545-56. 2010
    ..In embryonic limb development, fibroblast growth factor receptors (FGFRs) play a role in chondrogenic differentiation...
  9. ncbi Fibroblast growth factors, their receptors and signaling
    C J Powers
    School of Nursing, Department of Pharmacology, Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20007, USA
    Endocr Relat Cancer 7:165-97. 2000
    ..FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state...
  10. ncbi Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain
    Jonna Saarimäki-Vire
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 27:8581-92. 2007
    ..We propose a model for regulation of progenitor cell self-renewal and neuronal differentiation by combinatorial intercellular signals in the ventral midbrain...
  11. ncbi FGF8-like1 and FGF8-like2 encode putative ligands of the FGF receptor Htl and are required for mesoderm migration in the Drosophila gastrula
    Tanja Gryzik
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Curr Biol 14:659-67. 2004
    ..After gastrulation Htl is essential for the differentiation of dorsal mesodermal derivatives. It is not known how Htl is activated, because its ligand has not yet been identified...
  12. pmc Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene
    T Miki
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 89:246-50. 1992
    ..Thus, two growth factor receptors with different ligand-binding specificities and expression patterns are encoded by alternative transcripts of the same gene...
  13. ncbi A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
    Kimita Suyama
    Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Cell 2:301-14. 2002
    ..These results suggest that protection of the FGFR-1 from ligand-induced downregulation by N-cadherin enhances receptor signaling and provides a mechanism by which tumor cells can acquire metastatic properties...
  14. pmc Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis
    Y Zhang
    Department of Molecular Oral Medicine and Maxillofacial Surgery 1, Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
    Proc Natl Acad Sci U S A 98:11336-40. 2001
    ..Our results provided significant insight into the mechanism of KGFR tumor suppression and suggest that KGFR gene therapy might be a viable method of inhibiting human salivary adenocarcinoma growth...
  15. ncbi Identification of an N-cadherin motif that can interact with the fibroblast growth factor receptor and is required for axonal growth
    E J Williams
    Molecular Neurobiology Group, MRC Center for Developmental Neurobiology, King's College London, London SE1 1UL, United Kingdom
    J Biol Chem 276:43879-86. 2001
    ..Thus, we can conclude that N-cadherin contains a novel motility motif in extracellular domain 4, and that peptide mimetics of this motif can interact with the FGFR...
  16. pmc Fgfr2 is required for limb outgrowth and lung-branching morphogenesis
    E Arman
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:11895-9. 1999
    ..Possible epithelial-mesenchymal interactions between the splicing alternatives of Fgfr2 and their specific ligands will be discussed...
  17. ncbi Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
    X Xu
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Development 125:753-65. 1998
    ....
  18. ncbi Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
    Hiroshi Hanafusa
    Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Nat Cell Biol 4:850-8. 2002
    ..Our findings suggest that Spry functions in a negative feedback mechanism in which its inhibitor activity is controlled rapidly and reversibly by post-translational mechanisms...
  19. ncbi Fibroblast growth factor receptors as molecular targets in thyroid carcinoma
    Rosanne St Bernard
    Department of Pathology, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Endocrinology 146:1145-53. 2005
    ..These data indicate a role for FGFR-4 in human thyroid cancer cell progression and provide a rationale for FGFR manipulation as a potentially novel therapeutic approach...
  20. ncbi FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4
    M H Xie
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cytokine 11:729-35. 1999
    ..FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line...
  21. ncbi Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele
    Johannes Bange
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Cancer Res 62:840-7. 2002
    ..Our results support the conclusion that the FGFR4 Arg(388) allele represents a determinant that is innocuous in healthy individuals but predisposes cancer patients for significantly accelerated disease progression...
  22. ncbi Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
    D Cappellen
    Laboratoire de Morphogenèse Cellulaire et Progression Tumorale, UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Section de Recherche, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Genet 23:18-20. 1999
  23. ncbi Structural basis for FGF receptor dimerization and activation
    A N Plotnikov
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Cell 98:641-50. 1999
    ..A general model for FGF- and heparin-induced FGFR dimerization is inferred from the crystal structure, unifying a wealth of biochemical data...
  24. ncbi Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
    K C Hart
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093 0367, USA
    Oncogene 19:3309-20. 2000
    ..Moreover, our results suggest that Stat activation by FGFRs is important in their ability to act as oncogenes...
  25. ncbi The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
    A Demiroglu
    Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    Blood 98:3778-83. 2001
    ..The study demonstrates that the BCR-FGFR1 fusion may occur in patients with apparently typical CML. Patients with constitutively active FGFR1 fusion genes may be amenable to treatment with specific FGFR1 inhibitors...
  26. ncbi Murine FGFR-1 is required for early postimplantation growth and axial organization
    C X Deng
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:3045-57. 1994
    ..Such abnormalities are unlikely to be caused by intrinsic blocks in mesodermal differentiation, as FGFR-1-deficient ES cell lines form teratomas consisting of many mesodermal cell types...
  27. ncbi A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification
    Marios P Stavridis
    Division of Cell and Developmental Biology, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Development 134:2889-94. 2007
    ....
  28. ncbi Integration of FGF and TWIST in calvarial bone and suture development
    D P Rice
    Institute of Biotechnology and Institute of Dentistry, PO Box 56, Finland
    Development 127:1845-55. 2000
    ..We propose a model of osteoblast differentiation integrating Twist and FGF in the same pathway, in which FGF acts both at early and late stages. Disruption of this pathway may lead to craniosynostosis...
  29. ncbi Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis
    David Davidson
    Department of Medicine, Centre for Bone and Periodontal Research, McGill University, Montreal H3A 1A4, Canada
    J Biol Chem 280:20509-15. 2005
    ..This work, thus, identifies FGF18 and FGFR3 as potential molecular targets for intervention in tissue engineering aimed at cartilage repair and regeneration of damaged cartilage...
  30. ncbi The IIIc alternative of Fgfr2 is a positive regulator of bone formation
    Vereragavan P Eswarakumar
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot Israel
    Development 129:3783-93. 2002
    ..This role contrasts with the negative role of Fgfr3, although recent reports implicate FGF18, a ligand for FGFR3IIIc and FGFR2IIIc, as a co-ordinator of osteogenesis via these two receptors...
  31. ncbi The hedgehog pathway is a modulator of retina regeneration
    Jason R Spence
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Development 131:4607-21. 2004
    ..However, Hh inhibition increases the number of ganglion cells but does not have an effect on cell death. Taken together, our results suggest that the hedgehog pathway is an important modulator of retina regeneration...
  32. ncbi The Drosophila protein Dof is specifically required for FGF signaling
    S Vincent
    Biozentrum, Universität Basel Abt Zellbiologie, Switzerland
    Mol Cell 2:515-25. 1998
    ..Dof is needed in these cells for activation of the MAPK cascade via FGF signaling, but not for activation via other RTK ligands. Dof therefore appears to be committed exclusively to FGFR-mediated signal transduction...
  33. ncbi Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules
    Shuizi Rachel Yu
    Developmental Genetics, Biotechnology Center, TUD, Tatzberg 47 49, 01307 Dresden, Germany
    Nature 461:533-6. 2009
    ..Our results demonstrate that a freely diffusing morphogen can set up concentration gradients in a complex multicellular tissue by a simple source-sink mechanism...
  34. pmc Constitutive activation of fibroblast growth factor receptor 3 by the transmembrane domain point mutation found in achondroplasia
    M K Webster
    Department of Chemistry and Biochemistry, University of California, San Diego, 92093 0322, USA
    EMBO J 15:520-7. 1996
    ..Achondroplasia may be one of the number of cogenital disorders where constitutive activation of a member of the FGFR family leads to development abnormalities...
  35. ncbi Common and distinct elements in cellular signaling via EGF and FGF receptors
    Joseph Schlessinger
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 306:1506-7. 2004
    ..The differential circuitry of the intracellular networks that are activated by EGFR and FGFR may affect signal specificity and physiological responses...
  36. ncbi The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
    C Popovici
    Laboratoire d Oncologie Moleculaire, U 119 INSERM, Institut de Cancérologie et d Immunologie de Marseille, France
    Blood 93:1381-9. 1999
    ..It may promote hematopoietic stem cell proliferation and leukemogenesis through a constitutive phosphorylation and activation of the downstream pathway of FGFR1...
  37. ncbi A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis
    Lin Chen
    Genetics of Development and Disease Branch, NIDDK NIH, 10 9N105, 10 Center Drive, Bethesda, MD 20892, USA
    Bone 33:169-78. 2003
    ..Thus, our data reveal that dysregulated apoptosis plays an important role in the pathogenesis of AS related phenotypes...
  38. ncbi Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
    A N Plotnikov
    Department of Pharmacology, New York University School of Medicine, New York 10016, USA
    Cell 101:413-24. 2000
    ..These structures provide a molecular basis for FGF1 as a universal FGFR ligand and for modulation of FGF-FGFR specificity through primary sequence variations and alternative splicing...
  39. ncbi Fibroblast growth factor-9 modulates the expression of myelin related proteins and multiple fibroblast growth factor receptors in developing oligodendrocytes
    R I Cohen
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 4160, USA
    J Neurosci Res 61:273-87. 2000
    ..The effects of FGF-9 and FGF-2 on FGFR and myelin protein levels were comparable; both up-regulated FGFR-1, and down-regulated FGFR-2, CNP, PLP and MBP. These findings suggest that FGF-9 may be important for glial cell development...
  40. pmc Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities
    S Werner
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco 94143 0724
    Mol Cell Biol 12:82-8. 1992
    ..Our data provide the first evidence that differential splicing in the extracellular region of a receptor gene generates receptor variants with different ligand-binding specificities...
  41. ncbi FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
    B Ciruna
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Dev Cell 1:37-49. 2001
    ..We propose that modulation of cytoplasmic beta-catenin levels, associated with FGF-induced downregulation of E-cadherin, provides a molecular link between FGF and Wnt signaling pathways at the streak...
  42. ncbi Conserved use of a non-canonical 5' splice site (/GA) in alternative splicing by fibroblast growth factor receptors 1, 2 and 3
    S R Twigg
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Hum Mol Genet 7:685-91. 1998
    ..Inclusion or exclusion of the Val-Thr dipeptide may play an important role in controlling FGFR signalling through the Ras/MAPK pathway...
  43. ncbi Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3)
    Geraldine Guasch
    INSERM U119, the Institut de Cancérologie et d Immunologie de Marseille, France
    Blood 101:286-8. 2003
    ..RT-PCR detected only 1 of the 2 possible fusion transcripts, HERV-K/FGFR1...
  44. ncbi Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS
    E Shishido
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Japan
    Development 124:2119-28. 1997
    ..DFR1 mutant phenotypes were partially mimicked by the targeted expression of activated Yan, thus demonstrating the MAP kinase pathway to be involved in differentiation of mesoderm...
  45. ncbi Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis
    Julien H Dey
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Cancer Res 70:4151-62. 2010
    ..Of interest are the downregulated matrix metalloproteases (MMP), in particular MMP9, which is essential for metastatic spread of 4T1 tumors...
  46. pmc Fibroblast growth factor receptors control epithelial-mesenchymal interactions necessary for alveolar elastogenesis
    Sorachai Srisuma
    Division of Neonatology and Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Respir Crit Care Med 181:838-50. 2010
    ..Previous studies have identified impaired alveogenesis in mice bearing compound mutations of fibroblast growth factor (FGF) receptors (FGFRs) 3 and 4, indicating that these receptors cooperatively promote postnatal alveolar formation...
  47. ncbi Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase
    M Kan
    Department of Biochemistry, Texas A and M University, Texas A and M University System Health Science Center, Houston, Texas 77030 3303, USA
    J Biol Chem 274:15947-52. 1999
    ..In a physiological context, the heparan sulfate subunit may limit the redundancy among the current 18 FGF polypeptides for the 4 known FGFR...
  48. pmc Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis
    Shereen Ezzat
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 109:69-78. 2002
    ..Here we show that targeted expression of ptd-FGFR4, but not FGFR4, results in pituitary tumors that morphologically recapitulate the human disease...
  49. ncbi Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7)
    M Igarashi
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 273:13230-5. 1998
    ..These results indicate that FGF-10 and KGF have similar receptor binding properties and target cell specificities, but are differentially regulated by components of the extracellular matrix...
  50. ncbi Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
    M Mohammadi
    Department of Pharmacology, New York University Medical Center, New York, NY 10016, USA
    Science 276:955-60. 1997
    ..This structural information will facilitate the design of new inhibitors for use in the treatment of cancer and other diseases in which cell signaling by tyrosine kinases plays a crucial role in disease pathogenesis...
  51. ncbi Evolution of the Fgf and Fgfr gene families
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Trends Genet 20:563-9. 2004
    ..The expansion of the Fgf and Fgfr gene families has enabled this signaling system to acquire functional diversity and, therefore, an almost ubiquitous involvement in developmental and physiological processes...
  52. pmc Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm
    A Carmena
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma, 28049 Madrid, Spain
    Genes Dev 12:3910-22. 1998
    ..We conclude that distinct cellular identity codes are generated by the combinatorial activities of Wg, Dpp, EGF, and FGF signals in the progressive determination of embryonic mesodermal cells...
  53. ncbi Fibroblast growth factor signaling in tumorigenesis
    Richard Grose
    Cancer Research UK London Research Institute, Viral Carcinogenesis, Laboratory 214, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cytokine Growth Factor Rev 16:179-86. 2005
    ..Here, we outline the model systems that demonstrate the potential oncogenic nature of Fgf signaling and summarise recent evidence that implicates aberrant Fgf signaling as important in the natural history of some common human cancers...
  54. ncbi Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
    J Schlessinger
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell 6:743-50. 2000
    ..This model provides a structural basis for FGFR activation by small molecule heparin analogs and may facilitate the design of heparin mimetics capable of modulating FGF signaling...
  55. ncbi branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching
    D Sutherland
    Department of Biochemistry, Beckman Center, Stanford University School of Medicine, California 94305 5307, USA
    Cell 87:1091-101. 1996
    ....
  56. ncbi heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo
    S Gisselbrecht
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:3003-17. 1996
    ..These studies establish that Htl signaling provides a vital connection between initial formation of the embryonic mesoderm in Drosophila and subsequent cell-fate specification within this germ layer...
  57. ncbi The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects
    S D Skaper
    Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Essex, England
    J Neurochem 75:1520-7. 2000
    ..PD 173074 represents a valuable tool for dissecting the role of FGF-2 in normal and pathological nervous system function without compromising the actions of other neurotrophic factors...
  58. pmc FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation
    Snehalata Kadam
    California Institute of Technology, Division of Biology MC114 96, Pasadena, CA 91125, USA
    Development 136:739-47. 2009
    ..We contend that inherent properties of FGF ligands make them suitable to support specific FGF-dependent processes, and that FGF ligands are not always interchangeable...
  59. ncbi Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)
    D Intini
    Servizio Ematologia, Dipartimento di Scienze Mediche, Universita di Milano, Ospedale Maggiore di Milano, IRCCS, Milano, Italy
    Br J Haematol 114:362-4. 2001
    ..The Arg248Cys mutation, which is associated with some lethal forms of skeletal disorders, was found in one case with t(4;14). Our results indicate that FGFR3 mutations occur in only a small fraction of MM cases with t(4;14)...
  60. ncbi FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development
    H Ohuchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, 46 29 Yoshida shimo adachi cho, Sakyo ku, Kyoto City, Kyoto, 606 8501, Japan
    Biochem Biophys Res Commun 277:643-9. 2000
    ..These results suggest that FGF10 acts as a major ligand for FGFR2b in mouse multi-organ development...
  61. ncbi Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon
    V Tropepe
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada
    Dev Biol 208:166-88. 1999
    ..These results support a model in which separate, lineage-related EGF- and FGF-responsive neural stem cells are present in the embryonic telencephalic germinal zone...
  62. pmc Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis
    Philipp Niethammer
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    J Cell Biol 157:521-32. 2002
    ..Likewise, NCAM-triggered neurite outgrowth is also completely blocked by a specific FGF receptor inhibitor, indicating that cosignaling via raft-associated kinases and FGF receptor is essential for neuritogenesis...
  63. pmc Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors
    C Billerey
    Service d'Anatomie et de Cytologie Pathologiques, Centre Hospitalo-Universitaire de Rouen, , Rouen, France
    Am J Pathol 158:1955-9. 2001
    ..The absence of FGFR3 mutations in CIS and the low frequency of FGFR3 mutations in pT1 and pT2-4 tumors are consistent with the model of bladder tumor progression in which the most common precursor of pT1 and pT2-4 tumors is CIS...
  64. ncbi Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1
    A T Chellaiah
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110
    J Biol Chem 269:11620-7. 1994
    ..The uniquely limited repertoire of ligands that interact with this receptor suggests that a novel ligand for FGFR3 IIIb exists...
  65. pmc Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition
    B L Allen
    Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA
    J Cell Biol 155:845-58. 2001
    ..This suggests that FGF and FR recognition of specific HS sulfation patterns is critical for the activation of FGF signaling, and that synthesis of these patterns is regulated during embryonic development...
  66. ncbi Functions of fibroblast growth factors in vertebrate development
    M Goldfarb
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cytokine Growth Factor Rev 7:311-25. 1996
    ....
  67. pmc Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning
    G Celli
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 17:1642-55. 1998
    ....
  68. pmc Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts
    A Mansukhani
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    J Cell Biol 149:1297-308. 2000
    ..These data provide the first biochemical analysis of FGF signaling in osteoblasts, and show that FGF can act as a cell death inducer with distinct effects in proliferating and differentiating osteoblasts...
  69. ncbi A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors
    C Li
    Genetics of Development and Diseases Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases National Institutes of Health, 10 Center Drive, Bethesda, MD, USA
    Hum Mol Genet 8:35-44. 1999
    ....
  70. ncbi 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes
    Elena Belloni
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    Genes Chromosomes Cancer 42:320-5. 2005
    ..Thus, our data extend the involvement of FGFR1 in EMS and lend support to the concept that there is a precise correlation between genotype and phenotype in this disease...
  71. pmc Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy
    G Yan
    W Alton Jones Cell Science Center, Inc, Lake Placid, New York 12946
    Mol Cell Biol 13:4513-22. 1993
    ..Multiple autocrine and potentially intracrine ligand-receptor loops resulting from these alterations within the FGF-FGF-R family may underlie the autonomy of malignant tumor cells...
  72. ncbi Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4
    J M Revest
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
    Dev Biol 231:47-62. 2001
    ..5, providing evidence that Fgfs act primarily as survival factors. We propose that FgfR2-IIIb is not required for limb bud initiation, but is essential for its maintenance and growth...
  73. ncbi A novel form of FGF receptor-3 using an alternative exon in the immunoglobulin domain III
    A Avivi
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    FEBS Lett 330:249-52. 1993
    ..The results demonstrate that the presence of alternative exons for Ig-domain 3 is a general phenomena in FGFR1, 2 and 3, and represents a novel genetic mechanism for the generation of receptor diversity...
  74. ncbi Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epithelium
    P Hsu
    Centre for Molecular Neurobiology, School of Biomedical and Biomolecular Science, Griffith University, QLD 4111, Brisbane, Australia
    Brain Res 896:188-97. 2001
    ..The present study investigates the expression of basic fibroblast growth factor and fibroblast growth factor receptors in the adult olfactory epithelium...
  75. ncbi Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate. Implications for dynamic assembly of a ternary signaling complex
    Andrew K Powell
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
    J Biol Chem 277:28554-63. 2002
    ..We propose a mechanistic model where the kinetic parameters of the HS/FGFR interaction are a key element regulating the formation of ternary complexes and the resulting FGF signaling outcomes...
  76. pmc Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
    S H Ong
    Department of Pharmacology and The Skirball Institute, New York University, Medical School, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 98:6074-9. 2001
    ....
  77. pmc Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)
    C Popovici
    Laboratoire d Oncologie Moleculaire, Unite 119, Institut National de la Sante et de la Recherche Medicale, Institut de Cancérologie et Immunologie, 232 Boulevard Sainte Marguerite, 13009 Marseille, France
    Proc Natl Acad Sci U S A 95:5712-7. 1998
    ..The FIM/FGFR1 fusion protein contains the FIM putative zinc finger motifs and the catalytic domain of FGFR1. We show that it has a constitutive tyrosine kinase activity...
  78. ncbi Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm
    A M Michelson
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Genet 22:212-29. 1998
    ..Finally, parallels between requirements for FGFR signaling in Drosophila and vertebrate mesoderm development are considered...
  79. ncbi FGF2 triggers iris-derived lens regeneration in newt eye
    Toshinori Hayashi
    Graduate School of Frontier Biosciences, Osaka University, Suita, Japan
    Mech Dev 121:519-26. 2004
    ..The observations also indicate that the absence of lens regeneration from the ventral iris is due to a block in a later phase of lens developmental pathway...
  80. ncbi Synergistic activity of fibronectin and fibroblast growth factor receptors on neuronal adhesion and neurite extension through extracellular signal-regulated kinase pathway
    Pill Hoon Choung
    Intellectual Biointerface Engineering Center, Seoul National University College of Dentistry, 28 Yongon Dong, Chongno Gu, Seoul, Republic of Korea
    Biochem Biophys Res Commun 295:898-902. 2002
    ....
  81. ncbi Fibroblast growth factor-10 and fibroblast growth factor receptors 1-4: expression and peptide localization in human decidua and placenta
    Eyal Y Anteby
    Department of Obstetrics and Gynecology, Hadassah Hebrew University Medical Center, Mt Scopus, Jerusalem, Israel
    Eur J Obstet Gynecol Reprod Biol 119:27-35. 2005
    ..We hypothesized that fibroblast growth factor-10 (FGF-10) and fibroblast growth factor receptors 1-4 (FGFR 1-4) are expressed in human decidual and placental tissues...
  82. ncbi Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development
    C Deng
    Laboratory of Biochemistry and Metabolism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Biol 185:42-54. 1997
    ..Thus, FGFR-1 plays a role in neurulation, suggesting that there may be a connection between FGFR-1-mediated signal pathways and neural tube defects, the most common malformations in the human central nervous system...
  83. ncbi FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1alpha
    Riyaz N H Shah
    Cancer Research UK Molecular Oncology Unit, ICSM at Hammersmith Hospital, London W12 0NN, UK
    Oncogene 21:8251-61. 2002
    ..We conclude that HNF1alpha is a major determinant of FGFR4 expression in PC...
  84. ncbi Characterization of fibroblast growth factor receptors expressed in principal cells in the initial segment of the rat epididymis
    Jennifer L Kirby
    Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Biol Reprod 68:2314-21. 2003
    ..The current studies were undertaken to identify which fibroblast growth factor receptors (FGFRs) are present in the principal cells of the rat initial segment and to identify other ..
  85. ncbi Basic fibroblast growth factor activates ERK and induces c-fos in human embryonic stem cell line MizhES1
    Ho Bum Kang
    Department of Biochemistry, Biotechnology Research Institute, College of Natural Sciences, Chungbuk National University, Cheongju, Chungbuk, 361 763, Korea
    Stem Cells Dev 14:395-401. 2005
    ..mRNA and protein levels of the c-fos gene were increased by bFGF. Induction of c-Fos was dependent on MEKl. Therefore, it is likely that bFGF contributes to maintenance of human ES cells, at least in part, through the MEK1/ERK pathway...
  86. ncbi An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
    L De Moerlooze
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 127:483-92. 2000
    ..Our findings point to a key role for fibroblast growth factor receptor 2(IIIb) in mesenchymal-epithelial signalling during early organogenesis...
  87. ncbi FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos
    Robert Wilson
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, 50931 Koln, Germany
    Development 132:491-501. 2005
    ....
  88. ncbi Fibroblast growth factor receptors and their ligands in the adult rat kidney
    B Cancilla
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia
    Kidney Int 60:147-55. 2001
    ..The distributions of the FGFRs in the normal adult kidney and the restricted expression of FGF ligands suggest that specific FGFs have distinct and important roles in the maintenance of normal kidney structure and function...
  89. ncbi Fibroblast growth factor receptor 4, implicated in progression of islet cell carcinogenesis by its expression profile, does not contribute functionally
    D C Olson
    Hormone Research Institute, University of California, San Francisco, 94143 0534, USA
    Cell Growth Differ 9:557-64. 1998
    ..Analyses included the incidence and size of tumors, rate of cell proliferation, cell density, and life span. We conclude that FGFR4 gene activation is a marker of but is not causal for beta-cell transformation...
  90. ncbi Differential distribution of fibroblast growth factor receptors (FGFRs) on foveal cones: FGFR-4 is an early marker of cone photoreceptors
    Elisa E Cornish
    Save Sight Institute, University of Sydney, New South Wales, Australia
    Mol Vis 10:1-14. 2004
    ..We investigated expression of FGFRs in developing and adult Macaca monkey retina, paying particular attention to the cone rich, macular region...
  91. ncbi Detection of mRNA and immunoreactive proteins for acidic and basic fibroblast growth factor and expression of the fibroblast growth factor receptors in the bovine oviduct
    C Gabler
    Institute of Physiology, FML Weihenstephan, TU Munchen, Freising, Germany
    J Reprod Fertil 109:213-21. 1997
    ..In summary, the components of the FGF system were found in the bovine oviduct suggesting an autocrine or paracrine regulation involving oviduct cells and cumulus-oocyte complexes...
  92. ncbi alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors
    Michael Stapelberg
    School of Health Science, Griffith University, Southport, QLD, Australia
    Biochem Biophys Res Commun 318:636-41. 2004
    ..Our data suggest a novel mechanism by which a clinically intriguing agent selectively suppresses proliferation of cancer cells, as shown here for the untreatable mesotheliomas...
  93. ncbi Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila
    A M Michelson
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Development 125:4379-89. 1998
    ..A strong heartbroken allele also suppresses the effects of hyperactivated FGF but not EGF receptors. Thus, heartbroken may contribute to the specificity of developmental responses elicited by FGF receptor signalling...
  94. ncbi Differential regulation of fibroblast growth factor receptors in the regenerating amphibian spinal cord in vivo
    F Zhang
    Developmental Biology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Neuroscience 114:837-48. 2002
    ..may mediate FGF2 signaling and their role in regeneration, we have studied expression of the four fibroblast growth factor receptors, FGFR1, FGFR2, FGFR3 and FGFR4, and of the spliced variants, sFGFR and KGFR, in the regenerating ..
  95. ncbi The Drosophila FGF-R homolog is expressed in the embryonic tracheal system and appears to be required for directed tracheal cell extension
    L Glazer
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genes Dev 5:697-705. 1991
    ..However, the extension of tracheal cell processes leading to the formation of the elaborate tree structure is blocked. The DFGF-R protein may thus participate in receiving spatial cues that guide tracheal cell outgrowth...
  96. ncbi Selective over-expression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer
    K Sahadevan
    Urology Research Group, Northern Institute for Cancer Research, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Pathol 213:82-90. 2007
    b>Fibroblast growth factor receptors (FGFRs) mediate the tumourigenic effects of FGFs in prostate cancer. These receptors are therefore potential therapeutic targets in the development of inhibitors to this pathway...
  97. ncbi The choice between alternative IIIb and IIIc exons of the FGFR-3 gene is not strictly tissue-specific
    E Scotet
    INSERM U 211, Institut de Biologie, Nantes, France
    Biochim Biophys Acta 1264:238-42. 1995
    An essential feature of fibroblast growth factor receptors (FGFR) is the existence of multiple possibilities for alternative splicing...
  98. ncbi Osteogenic differentiation of murine embryonic stem cells is mediated by fibroblast growth factor receptors
    Kee Woei Ng
    Stem Cell and Tissue Repair Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore 138673
    Stem Cells Dev 16:305-18. 2007
    ..In particular, the data indicate that FGFR1 plays a pivotal role in osteoblast lineage determination...
  99. ncbi Distinct expression of two Drosophila homologs of fibroblast growth factor receptors in imaginal discs
    Y Emori
    Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Japan
    FEBS Lett 332:111-4. 1993
    ..These results suggest that DFR1 is involved in the development of mesodermal and neuronal cells constituting the adult body...
  100. ncbi A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
    H Kouhara
    Department of Pharmacology, New York University Medical Center, New York 10016, USA
    Cell 89:693-702. 1997
    ..Finally, we demonstrate that FRS2 is closely related and probably indentical to SNT, the long-sought target of FGF and NGF receptors...
  101. ncbi FGF6 modulates the expression of fibroblast growth factor receptors and myogenic genes in muscle cells
    S Pizette
    Laboratoire d Oncologie Moleculaire, U 119 INSERM, Marseille, France
    Exp Cell Res 224:143-51. 1996
    ..These results suggest that intramuscular FGF6 concentrations could influence the proliferation and differentiation processes taking place during development...

Research Grants77

  1. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2013
    ..The long-term objectives of this research are to elucidate the molecular mechanism of regulation of CYP7A1 and bile acid metabolism, and pathogenesis and treatment of metabolic diseases such as fatty liver disease, diabetes and obesity. ..
  2. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..We can also analyze tyrosine phosphorylation of the proteins and determine if they physically interact with each other in the embryo. ..
  3. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
    ..The ultimate goal of this research is to identify mechanisms that contribute to interneuron maturation and survival, possibly leading to novel therapies aimed at preventing or reversing interneuron disruption in psychiatric illnesses. ..
  4. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2013
    ..Since substrate recruitment and phosphorylation by RTKs is a general event in RTK signaling, the mechanistic insights gained under Aim IV will also be directly applicable to the entire RTK superfamily. ..
  5. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
    ..These studies will advance our understanding of the regulation of ASBT and provide new ways to understand and treat intestinal and liver diseases. ..
  6. Mechanisms of FGFR2 Signaling in Craniofacial Development
    Veraragavan P Eswarakumar; Fiscal Year: 2013
    ..It is anticipated that the findings will enable the design of novel pharmacological interventions for craniofacial disorders that are caused by dysfunction in FGFRs. ..
  7. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    JOHN CHIANG; Fiscal Year: 2009
    ..Drugs targeting to nuclear receptor and signaling pathways, and miRNA antagomirs may be developed for treating metabolic liver diseases. ..
  8. Regulation of Hepatic Metabolic Function by Parenteral Nutrition
    Douglas G Burrin; Fiscal Year: 2013
    ..These studies in premature pigs are highly translational and will lead to new clinical practices in nutritional support and prevention of liver disease in infants. ..
  9. PHENOGENETICS OF SKULL AND BRAIN INTEGRATION IN CRANIOSYNOSTOSIS
    JOAN THERESE RICHTSMEIER; Fiscal Year: 2012
    ..disorders including Crouzon, Apert and Pfeiffer syndromes are caused by mutations in fibroblast growth factor receptors (FGFR)-1, -2 or -3...
  10. MOLECULAR BIOLOGY OF BILE ACID SYNTHESIS
    John Y L Chiang; Fiscal Year: 2013
    ..Drugs targeting to nuclear receptor and signaling pathways, and miRNA antagomirs may be developed for treating metabolic liver diseases. ..
  11. Protein Kinase D2 Function and Signaling in Angiogenesis
    Hua Tang; Fiscal Year: 2012
    ..We anticipate that these studies will provide a strong rationale for PKD2 as a novel drugable target for therapeutic intervention in angiogenesis- related human diseases. ..
  12. Delivery of Soluble FGFR3 as a Treatment for Achondroplasia
    Steven C Ghivizzani; Fiscal Year: 2013
    ..4) To determine the relationship between age of intervention and the magnitude of the skeletal response following treatment with soluble FGFR3. ..
  13. Analysis of the Role of Sprouty Genes in Tooth Development
    Ophir Klein; Fiscal Year: 2009
    ..We will also study the role of adult stem cells in teeth, which may help to lay the groundwork for efforts to build new teeth. ..
  14. FGF SIGNALING IN SKELETAL DEVELOPMENT, HOMEOSTASIS AND AGING
    David M Ornitz; Fiscal Year: 2013
    ....
  15. Role of endocytosis by the neural crest in cardio-craniofacial development
    ANNA LUISE KEYTE; Fiscal Year: 2013
    ....
  16. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
    ..Both aspects may offer promising leads to correct or reverse the excitatory and inhibitory neuron imbalances that are present in the cerebral cortex of neuropsychiatric and impulse control disorders. ..
  17. Anti-HLA Antibody Activation of Endothelial Cells in Cardiac Transplantation
    Elaine F Reed; Fiscal Year: 2010
    ..Under Aim 2 we will assess the expression of anti-HLA antibody induced protein phosphorylation, fibroblast growth factor receptors and anti-apoptotic proteins in clinical biopsy specimens from cardiac allografts with and without ..
  18. Astroglial Cells in Perinatal Brain Injury
    Flora M Vaccarino; Fiscal Year: 2012
    ..Importantly, the regenerative processes investigated in this proposal could be mimicked in adult and aged individuals, in which unfortunately cortical neuron loss is not recovered. ..
  19. Fibroblast Growth Factor 23 (FGF23) and It's Receptors
    Jyothsna Gattineni; Fiscal Year: 2013
    ..It is known that the FGF family members bind to four fibroblast growth factor receptors (FGFRs) designated as FGFR1-4...
  20. Targeting FGFR to prevent the outgrowth of metastatic breast cancer
    MICHAEL KEITH WENDT; Fiscal Year: 2013
    ..More importantly, our studies will establish a diagnostic platform and therapeutic protocol for the inhibition of FGFR as an effective treatment option for TNBC patients undergoing metastatic tumor recurrence. ..
  21. Heparan sulfate proteoglycans in aging and development
    GREGORY COLE; Fiscal Year: 2009
    ..We predict that these proposed studies will provide important new insight into the function of agrin in the developing and aging nervous system. ..
  22. Role of FGF-Signaling in Myelinogenesis
    Rashmi Bansal; Fiscal Year: 2013
    ....
  23. A Novel Mitigation Agent for Gastrointestinal Syndrome of Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2009
    ..The results of these pre-clinical studies will provide the basis for eventual approval through the animal rule. A preliminary drug development plan has already been discussed with the FDA. ..
  24. Modulation of conjunctival goblet cell differentiation by immunoregulatory cells
    Cintia Sade de Paiva; Fiscal Year: 2010
    ..These studies will provide new information about natural mechanisms to control inflammation on the ocular surface and may provide new insight into treating ocular surface inflammatory diseases. ..
  25. CLINICAL AND GENETIC ANALYSIS OF ADHR
    Michael J Econs; Fiscal Year: 2013
    ....
  26. Lumicrine regulation of epididymal function
    Barry T Hinton; Fiscal Year: 2010
    ..This proposal is part of a long term goal to understand the mechanisms by which the epididymis maintains an optimal luminal microenvironment for sperm maturation and survival, and therefore male fertility. ..
  27. Control of FGF23 Bioactivity via Circulating alpha-Klotho
    Kenneth E White; Fiscal Year: 2013
    ..We expect our studies will provide novel, translational insight into rare, and common syndromes of altered FGF23 expression such as CKD-MBD, and into the basic biology of phosphate metabolism. ..
  28. Role of FGF10 in liver organogenesis and alcohol-impaired regeneration
    KASPER SAONUN WANG; Fiscal Year: 2010
    ..We postulate that the mechanism by which alcohol impairs liver regeneration may be due to impaired signaling through the FGF10/FGFR2b pathway we show normally promotes liver regeneration. ..
  29. Inorganic phosphate regulated proliferation, transformation and tumorigenesis
    George R Beck; Fiscal Year: 2013
    ..This proposal will investigate the role of dietary inorganic phosphate in cancer initiation, promotion and progression. ..
  30. Feedback Inhibitory Mechanisms in Skeletal Development
    Robert E Friesel; Fiscal Year: 2011
    The fibroblast growth factors (FGFs) and the fibroblast growth factor receptors (FGFRs) play important roles in development, including skeletal and craniofacial development...
  31. FGF2 Isoforms in Bone and Phosphate Homeostasis
    MARJA MARIE HURLEY; Fiscal Year: 2013
    ..abstract_text> ..
  32. Potential of a dominant-negative FGF mutant as a therapeutic in cancer
    Yoshikazu Takada; Fiscal Year: 2012
    ....
  33. Inflammation in Breast Cancer Initiation and Promotion
    Kathryn L Schwertfeger; Fiscal Year: 2013
    ..In the longer term, patients at high risk for breast cancer may benefit from specific anti-inflammatory therapies that could be used to inhibit tumor formation and progression. ..
  34. Characterization of the interplay between SEC23A and the MAPK signaling pathway
    Jinoh Kim; Fiscal Year: 2013
    ....
  35. Role of receptor tyrosine kinase signaling in branching morphogenesis
    PENGFEI PAUL LU; Fiscal Year: 2010
    ..If deregulation of RTK signaling could be prevented then we would greatly improve therapeutic interventions of human congenital illnesses inflicting the above epithelial organs and save the lives of millions of patients. ..
  36. DIVERSIFYING MICA TO CREATE TARGETED ADAPTERS TO RECRUIT AND ACTIVATE NK CELLS TO
    DAVID WILLIAM MARTIN; Fiscal Year: 2013
    ..We intend to demonstrate in vitro specific killing of human cells expressing FGFR3. ..
  37. PRODUCTION OF ALTERNATIVE FGF RECEPTOR FORMS IN TUMORS
    Gilbert J Cote; Fiscal Year: 2010
    ..A better understanding of this process may shed light on the transformation of astrocytes and provide new targets for suppressing their malignant growth. ..
  38. FGF Receptor in Myelin Function and Disease
    Rashmi Bansal; Fiscal Year: 2012
    ..Clarification of the role of FGF signaling in these processes can be expected to contribute to an informed clinical intervention to encourage remyelination and/or discourage demyelination. ..
  39. Competition and morphogenesis in tip cell-mediated branching of tubular networks
    Amin S Ghabrial; Fiscal Year: 2013
    ..3. To test the hypothesis that Polychaetoid and Too Many Leaders are downstream effectors of Notch signaling during tip cell competition. ..
  40. Role of Receptors in the Metanephric Mesenchyme
    CARLTON MATTHEW BATES; Fiscal Year: 2013
    ..b>Fibroblast growth factor receptors (Fgfrs) that signal through adapter proteins such as fibroblast growth factor receptor substrate 2[..
  41. Studies of the Roles of Twist1 and E12 in Tooth Morphogenesis
    Yongbo Lu; Fiscal Year: 2012
    ....
  42. The role of social interaction in restoring the GnRH system.
    JOHANNA RUTH ROCHESTER; Fiscal Year: 2012
    ..abstract_text> ..
  43. Molecular genetic analysis of astrocyte development and function
    Marc R Freeman; Fiscal Year: 2013
    ..Our work will provide fundamental knowledge about how astrocytes develop and regulate their growth in the brain, and is expected to provide critical insights into how defects in astrocyte growth or function cause disease. ..
  44. Growth Factor Signaling in Intestinal Development
    Steven Cohn; Fiscal Year: 2009
    ..The operant FGFR3 signaling pathways in intestinal epithelial cell lines, especially those impinging on TCF-4, will be investigated using a combination of biochemical and molecular approaches. ..
  45. An Artificial Golgi: Controlled GAG Synthesis and Screening
    ROBERT J contact LINHARDT; Fiscal Year: 2010
    ..This artificial Golgi uses a digital microfluidic platform for synthesis and screen activity on a cell microarray to develop a structure activity relationship for fibroblast growth factor signaling. ..
  46. Ras and Phosphoinositide 3-kinase Signaling in Lens Development
    Lixing W Reneker; Fiscal Year: 2012
    ..Other investigators have shown that signals activated by fibroblast growth factor receptors (FGFRs) are essential for fiber cell differentiation and lens cell survival...
  47. A genetic model of vesicoureteral reflux and reflux nephropathy
    CARLTON MATTHEW BATES; Fiscal Year: 2012
    ..We have a mouse mutant that develops reflux and subsequent reflux nephropathy. This mouse model will help us determine how best to treat children with this condition. ..
  48. Study of White Matter Development in a Rodent Model of Perinatal Brain Injury
    S ALI FATEMI; Fiscal Year: 2013
    ..Aim 2 involves modulating the expression of fibroblast growth factor receptors in glial precursors using molecular biological techniques to improve the in vitro and in vivo ..
  49. High throughput assays for modulators of splicing switches during the EMT
    RUSS PAUL CARSTENS; Fiscal Year: 2011
    ..The current application will use innovative splicing assays to carry out screens for novel compounds that inhibit this splicing transition and thereby identify lead compounds for drugs to prevent tumor metastasis. ..
  50. FRS2-mediated Signals in Prostatic Tumorigenesis and Development
    Fen Wang; Fiscal Year: 2013
    ..This project is to use genetically engineered mouse models and in vitro biochemical and molecular biological methods to study the roles of FRS2?-mediated signals in prostate development and tumorigenesis. ..
  51. The role of FGF signaling in suppressing astrogliosis
    Jean M Hebert; Fiscal Year: 2012
    ..This leads us to the hypothesis that FGF receptors act cell autonomously in the absence of injury to suppress astrogliosis. ..
  52. NIAMS: CORT
    Thomas O Carpenter; Fiscal Year: 2010
    ..Most importantly the CORT will provide a successful working model of translational research for Yale and the wider biomedical academic community. ..
  53. GENETIC REGULATORY NETWORK IN CRANIOFACIAL DEVELOPMENT
    Wei Hsu; Fiscal Year: 2013
    ....
  54. The role of GSH in cornea and lens development
    Vasilis Vasiliou; Fiscal Year: 2013
    ..Since the aforementioned signaling pathways are not restricted to the eye, the new knowledge derived from the proposed studies may have relevance and be extended to general embryogenesis and organogenesis. ..
  55. SPORE in Genitourinary Cancer
    Colin P N Dinney; Fiscal Year: 2013
    ..Achievement of the aims and objectives of this proposal will result in a major decrease in the incidence, morbidity and mortality of BC. ..
  56. The Roles of FGF9 and FGF18 in Skeletal Development
    Irene H Hung; Fiscal Year: 2013
    ..Craniosynostosis and chondrodysplasias are skeletal dysplasias caused by activating mutations in fibroblast growth factor receptors (Fgfrs), highlighting the critical role of FGF signaling in both membranous and endochondral bone ..
  57. EMT, Extravasation and metastasis by N-Cadherin signaling
    Rachel B Hazan; Fiscal Year: 2013
    ..We will rule out the role of N-cadherin adhesion in this process. We believe these studies will broaden our understanding of mechanisms that regulate breast cancer metastasis and will provide insights into therapeutic application. ..
  58. Genetic analysis of forebrain patterning and neurogenesis
    Jean M Hebert; Fiscal Year: 2013
    ..In Aim 3, we determine whether and how Foxg1 participates in regulating Cdkn1a transcription in early telencephalic cells in vivo and whether Foxg1, Smad4, and Cdkn1a genetically interact. ..
  59. Developing Neuroendocrine Brain, Androgen, and Fibroblast Growth Factor Signaling
    WILSON CHUNG; Fiscal Year: 2010
    ..Therefore, novel insights in how FGF expression is regulated by testosterone may help us better understand the mechanisms involved in the onset of Kallmann syndrome. ..
  60. FGF9 REGULATION OF LUNG DEVELOPMENT AND PATHOGENESIS OF PLEUROPULMONARY BLASTOMA
    David M Ornitz; Fiscal Year: 2013
    ....
  61. Synthetic Heparan Sulfate: Probing Biosynthesis to Prepare Defined Drugs
    Jian Liu; Fiscal Year: 2013
    ..Aim 3: To characterize the structure/function relationship of HS activity as the co-receptor fibroblast growth factor receptor signaling. ..
  62. WNTs, FGFs, and BMPs Induce and Maintain the Telencephalon
    Jean M Hebert; Fiscal Year: 2013
    ....
  63. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    ..There the cells express fibroblast growth factor receptors (FGFRs) 1,2 and 3 in specific, overlapping patterns where they mediate signals for cellular ..
  64. PARVOVIRUS VECTORS FOR HUMAN GENE THERAPY
    Arun Srivastava; Fiscal Year: 2002
    ..The knowledge gained from these studies will be applicable in further development of AAV and parvovirus B19 vectors and their optimal use in gene therapy of beta-thalassemia and sickle-cell disease. ..
  65. PARVOVIRUS VECTORS FOR HUMAN GENE THERAPY
    Arun Srivastava; Fiscal Year: 2004
    ..The knowledge gained from these studies will be applicable in further development of AAV and parvovirus B19 vectors and their optimal use in gene therapy of beta-thalassemia and sickle-cell disease. ..
  66. Defective nuclear FGFR1 signaling - a new model for PD
    MICHAL STACHOWIAK; Fiscal Year: 2003
    ..abstract_text> ..
  67. ACTIVATION OF PERIODONTAL FIBROBLASTS VIA CD40
    Timothy Blieden; Fiscal Year: 2000
    ..Fixed human T cell clones will be used as the source of CD40L. The results of these studies may lead to new concepts of cellular function and interactions in periodontal tissue breakdown and repair. ..
  68. FIBROBLAST GROWTH FACTOR RECEPTORS IN CRANIOSYNOSTOSIS
    ETHYLIN JABS; Fiscal Year: 1999
    ..Identification of FGFR2/KGFR mutations and their biologic effects will be important for accurate diagnosis and elucidation of the pathogenesis of these craniosynostotic conditions. ..
  69. DYSFUNCTIONAL FGFR SIGNALING IN CRANIOSYNOSTOSIS
    Robert Friesel; Fiscal Year: 2002
    ..Together, these studies should begin to elucidate the role of mutant FGFRs in the pathogenesis of craniosynostotic conditions, as well as the role of FGFRs in normal bone growth and development. ..
  70. STROMAL INFLUENCES ON BREAST CANCER PROGRESSION
    SANDRA MCLESKEY; Fiscal Year: 1999
    ..Transcription of such genes might be an important downstream event of FGFR stimulation and the protein products of such genes might be important in determining the phenotype of the tumor. ..
  71. TRANSCRIPTIONAL REGULATION BY FIBROBLAST GROWTH FACTOR
    Dwight Towler; Fiscal Year: 2001
    Signaling via fibroblast growth factor receptors(FGFRs) -1 and -2 coordinates connective tissue remodeling during wound repair and contributes to the responses of osteoblasts to metastatic bone cancers...
  72. CELLULAR COMMUNICATION IN MORPHOGENESIS
    Mark Krasnow; Fiscal Year: 2003
    ..Mutant clones that fail to attract are presumably unable to respond to hypoxia. A variation of the well established FLP/FRT system that allows examination of clones in living larvae is suggested for this purpose. ..
  73. Oligodendrocyte Differentiation and Myelin Biogenesis
    Rashmi Bansal; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page .................................................................................................................................................. 1 Description, ..
  74. FIBROBLAST GROWTH FACTOR RECEPTOR IN EARLY DEVELOPMENT
    Thomas Musci; Fiscal Year: 1992
    ..Understanding the early molecular events that direct differentiation pathways and control embryonic development is essential to the full understanding of the pathogenesis of these conditions...
  75. FIBROBLAST GROWTH FACTORS AND STRIATED MUSCLE
    JUDITH SWAIN; Fiscal Year: 1993
    ..The analysis of these transgenic mice is anticipated to elucidate the role of these heparin binding growth factors in cardiac and skeletal muscle development...
  76. FIBROBLAST GROWTH FACTORS AND STRIATED MUSCLE
    JUDITH SWAIN; Fiscal Year: 2001
    ..The analysis of these transgenic mice is anticipated to elucidate the role of these heparin binding growth factors in cardiac and skeletal muscle development. ..
  77. FIBROBLAST GROWTH FACTORS IN INFLAMMATORY BOWEL DISEASE
    Steven Cohn; Fiscal Year: 2002
    ..10 transgenic mice after administration of OVA peptide. ..