Genomes and Genes
Summary: Antibodies produced by human or animal cells following clinical or experimental exposure to parasitic PROTOZOAN ANTIGENS.
Publications289 found, 100 shown here
- Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposureC J Drakeley
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
Proc Natl Acad Sci U S A 102:5108-13. 2005..Thus, serological tools allow us to detect variations in malaria transmission over time. Such tools will be invaluable for monitoring trends in malaria endemicity and the effectiveness of malaria control programs...
- Serology: a robust indicator of malaria transmission intensity?Patrick Corran
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine LSHTM, Keppel St, London, WC1E 7HT, UK
Trends Parasitol 23:575-82. 2007..Here we present a suggested methodology, highlight the advantages and shortcomings of serological measurements of malaria transmission and identify areas in which further work is desirable...
- Dried blood spots as a source of anti-malarial antibodies for epidemiological studiesPatrick H Corran
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Malar J 7:195. 2008..Although recommendations for the storage and analysis of small molecule analytes in blood spots exist, there are no published systematic studies of the stability of antibodies under different storage conditions...
- Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illnessDanielle I Stanisic
Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
Infect Immun 77:1165-74. 2009..However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation...
- Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malariaP C Bull
Kenya Medical Research Institute CRC, Kilifi Unit
Nat Med 4:358-60. 1998..The apparent selective pressure exerted by established anti-PfEMP1 antibodies on infecting parasites supports the idea that such responses provide variant-specific protection against disease...
- Malaria in pregnancy: pathogenesis and immunityStephen J Rogerson
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
Lancet Infect Dis 7:105-17. 2007....
- Failure to respond to the surface of Plasmodium falciparum infected erythrocytes predicts susceptibility to clinical malaria amongst African childrenC L Mackintosh
Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi District Hospital, Kilifi, Kenya
Int J Parasitol 38:1445-54. 2008..Identification of this target will significantly aid understanding of naturally acquired immunity to clinical malaria amongst children in endemic areas...
- Human antibodies to recombinant protein constructs of Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) and their associations with protection from malariaSpencer D Polley
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Vaccine 23:718-28. 2004..Results encourage the development of an AMA1 vaccine based on the full-length ectodomain, and indicate that the function of human antibodies to allele-specific and conserved epitopes in AMA1 should be studied further...
- A principal target of human immunity to malaria identified by molecular population genetic and immunological analysesD J Conway
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT
Nat Med 6:689-92. 2000..This demonstrated that serum IgG antibodies against each of the two most frequent allelic types of block 2 of the protein were strongly associated with protection from P. falciparum malaria...
- Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian childrenDaniel Dodoo
Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
Malar J 7:142. 2008..This study was aimed at assessing in a standardized manner the relationship between the antibody responses to four malaria vaccine candidate antigens and protection from clinical malaria, in a cohort of Ghanaian children...
- Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotesJean Loup Lemesre
Institut de Recherche pour le Developpement, UR 008 Pathogénie des Trypanosomatidae, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France
Vaccine 23:2825-40. 2005..infantum-infected CM-DM were co-cultured with autologous lymphocytes. Overall, our results support the view that a LiESAp vaccine might be useful in a promising vaccination approach against natural L. infantum infection...
- Pathogenesis of chronic Chagas heart diseaseJose Antonio Marin-Neto
Cardiology Division, Department of Internal Medicine, Medical School of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
Circulation 115:1109-23. 2007..Despite nearly 1 century of research, the pathogenesis of chronic Chagas cardiomyopathy is incompletely understood, the most intriguing challenge of which is the complex host-parasite interaction...
- Antibodies to the conserved C-terminal domain of the Plasmodium falciparum merozoite surface protein 1 and to the merozoite extract and their relationship with in vitro inhibitory antibodies and protection against clinical malaria in a Senegalese villageRonald Perraut
Unite d immunologie, Institut Pasteur de Dakar, 36 Ave Pasteur, BP 220, Dakar, Senegal
J Infect Dis 191:264-71. 2005..High levels of anti-PfMSP-1p19 immunoglobulin G were associated with reduced malaria in an age-adjusted multivariate analysis. These results support baculovirus PfMSP-1p19-based vaccine development...
- Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodiesKristina E M Persson
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Clin Invest 118:342-51. 2008..falciparum and that a broad inhibitory response against multiple ligands may be required for effective immunity...
- Toxoplasma gondii infection in the United States: seroprevalence and risk factorsJ L Jones
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
Am J Epidemiol 154:357-65. 2001..gondii. Most women of childbearing age in the United States are susceptible to acute infection and should be educated about ways to minimize exposure to T. gondii...
- Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian childrenD Dodoo
Immunology and Epidemiology Units, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
Infect Immun 69:3713-8. 2001..In contrast, the levels of IgG to a peptide derived from a conserved part of PfEMP1 did not correlate with protection from malaria...
- Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of agePhilip Bejon
Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
N Engl J Med 359:2521-32. 2008..We evaluated the efficacy of RTS,S given with a more immunogenic adjuvant system (AS01E) in children 5 to 17 months of age, a target population for vaccine licensure...
- The carboxy-terminus of merozoite surface protein 1: structure, specific antibodies and immunity to malariaA A Holder
Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London
Parasitology 136:1445-56. 2009..Understanding the structure of MSP1 will help us design and engineer better antigens that are more effective than the first generation of vaccine candidates. This review is focused on the carboxy-terminus of MSP1...
- Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malariaFaith H A Osier
KEMRI Centre for Geographic Medicine Research, Coast, P O Box 230 80108, Kilifi, Kenya
Infect Immun 76:2240-8. 2008....
- Transient cross-reactive immune responses can orchestrate antigenic variation in malariaMario Recker
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Nature 429:555-8. 2004..Antigenic variation has always been seen as an adaptation of the parasite to evade host defence: we show that the coordination necessary for the success of this strategy might be provided by the host...
- Efficacy of two alternate vaccines based on Plasmodium falciparum merozoite surface protein 1 in an Aotus challenge trialA W Stowers
Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Inc, Rockville, Maryland 20852, USA
Infect Immun 69:1536-46. 2001..Vaccine formulation in an alternate adjuvant, MF59, resulted in significantly lower antibody titers and no protection...
- Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum antigens and protection from infectionChandy C John
Center for Global Health and Diseases, Rainbow Center for International Child Health, Division of Pediatric Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, USA
Am J Trop Med Hyg 73:222-8. 2005..High levels of IgG antibodies to CSP, LSA-1, and TRAP may be useful immune correlates of protection against P. falciparum infection in malaria-endemic populations...
- Altered immune responses in mice with concomitant Schistosoma mansoni and Plasmodium chabaudi infectionsH Helmby
Department of Immunology, Stockholm University, Stockholm, Sweden
Infect Immun 66:5167-74. 1998..mansoni-P. chabaudi-infected mice. Taken together, our data show that schistosoma and malaria infections profoundly affect each other, findings which might have implications for the development of vaccines...
- Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantumSima Rafati
Molecular Immunology Lab, Department of Immunology, Pasteur Institute of Iran, P O Box 11365 6699, Tehran, Iran
Vaccine 23:3716-25. 2005..We propose that the combination of DNA and recombinant protein vaccination using CPs could be instrumental to control (VL) in dogs...
- Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunityMorten A Nielsen
Center for Medical Parasitology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
J Immunol 168:3444-50. 2002..This opens the possibility of developing morbidity-reducing vaccines targeting a limited subset of common and particularly virulent VSA...
- Induction of adhesion-inhibitory antibodies against placental Plasmodium falciparum parasites by using single domains of VAR2CSAMorten A Nielsen
Department of International Health, Immunology, and Microbiology, University of Copenhagen, Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark
Infect Immun 77:2482-7. 2009..As the inhibition was not limited to homologous parasite strains, it seems feasible to base a protective malaria vaccine on a single VAR2CSA DBL domain...
- Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigensMichael F Ofori
Immunology and Epidemiology Units, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
Infect Immun 70:2982-8. 2002..The data from this first detailed longitudinal study of acquisition of VSA antibodies support the hypothesis that naturally acquired protective immunity to P. falciparum malaria is mediated, at least in part, by VSA-specific antibodies...
- Long lasting protection against canine kala-azar using the FML-QuilA saponin vaccine in an endemic area of Brazil (São Gonçalo do Amarante, RN)G P Borja-Cabrera
Instituto de Microbiologia, Prof Paulo de Góes, Universidade Federal do Rio de Janeiro UFRJ, CCS, Cidade Universitaria, Ilha do Fundao, Caixa Postal 68040, CEP 21941 590, Brazil
Vaccine 20:3277-84. 2002..Higher seropositivities and intradermal reactions with no Leishmanial DNA were detected in vaccinees. The FML-QuilA vaccine induced a significant, long lasting and strong protective effect against canine kala-azar in the field...
- Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malariaDavid R Cavanagh
Institute of Cell, Animal and Population Biology, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Rd, EH9 3JT, Scotland, UK
Infect Immun 72:6492-502. 2004..The results support a conclusion that the block 2 region of MSP-1 is a target of protective immunity against P. falciparum and, thus, a promising new candidate for the development of a malaria vaccine...
- Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivaxMayara B Barbedo
Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Súo Paulo, Brasil
Mem Inst Oswaldo Cruz 102:335-9. 2007..The reason for that is presently unknown but it may contribute to the high risk of re-infection in individuals living in the endemic areas...
- The sickle cell trait is associated with enhanced immunoglobulin G antibody responses to Plasmodium falciparum variant surface antigensGerardo Cabrera
Department of Parasitology, Institute for Tropical Medicine, University of Tubingen, Tubingen, Germany
J Infect Dis 191:1631-8. 2005..The results imply that enhanced levels of cross-reactive anti-VSA responses in children with HbAS may be intimately associated with the protection they have against malaria...
- Detailed analysis of an experimental challenge model for Leishmania infantum (JPC strain) in dogsJacqueline Poot
Intervet International B V, Parasitology R and D, Wim de Korverstraat 35, 5831 AN Boxmeer, The Netherlands
Vet Parasitol 130:41-53. 2005..However, this procedure did result in infection in 80% of the dogs and is appealing for future development as a natural challenge model in vaccine development...
- Repeat sequences in block 2 of Plasmodium falciparum merozoite surface protein 1 are targets of antibodies associated with protection from malariaSpencer D Polley
London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Infect Immun 71:1833-42. 2003..The results are important for design of a vaccine to induce protective antibodies, and they address hypotheses about repeat sequences in malaria antigens...
- Crystal structure of a Fab complex formed with PfMSP1-19, the C-terminal fragment of merozoite surface protein 1 from Plasmodium falciparum: a malaria vaccine candidateJ C Pizarro
Unité d Immunologie Structurale CNRS URA 2185, Departement de Biologie Structurale et Chimie, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, Cedex 15, France
J Mol Biol 328:1091-103. 2003..Although the epitope includes residues that have been mapped to regions recognised by invasion-inhibiting antibodies studied by other workers, G17.12 does not inhibit erythrocyte invasion or MSP1 processing...
- The role of CpG ODN in enhancement of immune response and protection in BALB/c mice immunized with recombinant major surface glycoprotein of Leishmania (rgp63) encapsulated in cationic liposomeMahmoud R Jaafari
School of Pharmacy, Biotechnology Research Center and Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Vaccine 25:6107-17. 2007..The results indicate that co-encapsulation of CpG ODN in liposomes improves the immunogenicity of Leishmania antigen...
- Prevalence of IgG antibodies specific to Toxoplasma gondii among blood donors in Recife, Northeast BrazilRaquel A L Coêlho
Laboratório de Imunopatologia Keizo Asami and Departamento de Bioquímica, Unviersidade Federal de Pernambuco, Recife, PE, Brasil
Rev Inst Med Trop Sao Paulo 45:229-31. 2003..4%). This percentage increases with age, ranging from 18.2% to 92.6% for individuals aging under 20 and 40-50 years old, respectively. For women of childbearing age (18-40 years) it was found a prevalence of 51.6%...
- Different response to Plasmodium falciparum in west African sympatric ethnic groups: possible implications for malaria control strategiesD Modiano
Dipartimento di Biologia Molecolare, Cellulare e Animale, Universita di Camerino, Italy
Parassitologia 41:193-7. 1999..These differences should be considered in the development of anti-malaria vaccines and in the evaluation and application of malaria control strategies...
- Antibody responses to a panel of Plasmodium falciparum malaria blood-stage antigens in relation to clinical disease outcome in SudanNnaemeka C Iriemenam
Department of Immunology, Wenner Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
Vaccine 27:62-71. 2009..The study provides further support for the potential importance of the studied merozoite vaccine candidate antigens as targets for parasite neutralizing antibody responses of the IgG1 and IgG3 subclasses...
- Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protectionKent E Kester
Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
J Infect Dis 200:337-46. 2009..To further increase the efficacy of malaria vaccine RTS,S/AS02A, we tested the RTS,S antigen formulated using the AS01B Adjuvant System (GlaxoSmithKline Biologicals)...
- Longitudinal study of natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in a holoendemic region of malaria in western Kenya: Asembo Bay Cohort Project VIIIV Udhayakumar
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia, USA
Am J Trop Med Hyg 65:100-7. 2001..009). Responses to AMA-1 T-cell epitopes were short lived, and antibody responses were relatively stable...
- Malaria and blood transfusionA D Kitchen
National Blood Service, London, UK
Vox Sang 90:77-84. 2006..Nonetheless, no matter what strategy is adopted, it is likely that cases of transfusion-transmitted malaria may still occur, so malaria must always be considered in any patient with a febrile illness post-transfusion...
- Toxoplasma gondii and schizophreniaE Fuller Torrey
Stanley Medical Research Institute, Bethesda, Maryland 20814 2142, USA
Emerg Infect Dis 9:1375-80. 2003..gondii in cell culture. Establishing the role of T. gondii in the etiopathogenesis of schizophrenia might lead to new medications for its prevention and treatment...
- Bacterially expressed and refolded receptor binding domain of Plasmodium falciparum EBA-175 elicits invasion inhibitory antibodiesKailash C Pandey
Malaria Research Group, International Centre for Genetic Engineering and Biotechnology, P O Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
Mol Biochem Parasitol 123:23-33. 2002..falciparum field isolate that invades erythrocytes using multiple pathways. These observations support the development of recombinant PfF2 as a vaccine candidate for P. falciparum malaria...
- Anti-MSP1 block 2 antibodies are effective at parasite killing in an allele-specific manner by monocyte-mediated antibody-dependent cellular inhibitionCorine Demanga Galamo
Biomedical Parasitology Unit, Pasteur Institute, Paris, France
J Infect Dis 199:1151-4. 2009..However, the ADCI effect was strictly allele specific. Our findings highlight a new mechanism involving MSP1 in the protection against malaria...
- High throughput functional assays of the variant antigen PfEMP1 reveal a single domain in the 3D7 Plasmodium falciparum genome that binds ICAM1 with high affinity and is targeted by naturally acquired neutralizing antibodiesAndrew V Oleinikov
Seattle Biomedical Research Institute, Seattle, Washington, USA
PLoS Pathog 5:e1000386. 2009..Our high throughput approach will significantly accelerate studies of PfEMP1 binding domains and protective antibody responses...
- Antigenicity and immunogenicity of recombinant glutamate-rich protein of Plasmodium falciparum expressed in Escherichia coliM Theisen
Department of Infection Immunology, Statens Seruminstitut, Copenhagen S, Denmark
Clin Diagn Lab Immunol 2:30-4. 1995..falciparum grown in vitro. These results demonstrate that GLURP produced in E. coli can induce a humoral immune response against GLURP derived from blood-stage parasites...
- Host resistance in the brain against Toxoplasma gondiiYasuhiro Suzuki
Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, California, USA
J Infect Dis 185:S58-65. 2002..Strains of T. gondii also affect development of TE. Genotypes of the parasite may be an important factor for determining development of TE...
- Seroepidemiology of Toxoplasma gondii infection in pregnant women in rural Durango, MexicoC Alvarado-Esquivel
Faculty of Medicine, Juárez University of Durango State, Avenida Universidad S N esquina Fanny Anitua, 34000 Durango, Dgo, Mexico
J Parasitol 95:271-4. 2009..6%). Multivariate analysis showed that T. gondii infection was associated with soil floors at home (adjusted OR = 2.89; 95% CI: 1.12-7.49). This is the first epidemiological study of T. gondii infection in pregnant women in rural Mexico...
- Vaccination with a plasmid DNA cocktail encoding the nucleosomal histones of Leishmania confers protection against murine cutaneous leishmaniosisSalvador Iborra
Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Campus de Cantoblanco, Madrid E 28049, Spain
Vaccine 22:3865-76. 2004..major infection, and that both CD4(+) and CD8(+) T cells contribute to the resistance of vaccinated mice to cutaneous leishmaniasis...
- A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantumI Molano
Section of Parasitology and Parasitic Diseases, Department of Medicine and Animal Health Veterinary Faculty, University of Extremadura, 10071 Caceres, Spain
Vet Immunol Immunopathol 92:1-13. 2003..A positive delayed type hypersensitivity (DTH) response was observed in nine of the immunized protected dogs. The data indicated that Q+BCG confers 90% protection against infection and at least 90% protection at the clinical level...
- Immunization with A2 protein results in a mixed Th1/Th2 and a humoral response which protects mice against Leishmania donovani infectionsA Ghosh
Department of Microbiology and Immunology, McGill University, 3557 University Street, Que, Montreal, Canada, H3A 2B4
Vaccine 20:59-66. 2001..These data demonstrate that A2 represents a potential antigen for protection against infection with L. donovani and VL...
- Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malariaSimon J Draper
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK
Cell Host Microbe 5:95-105. 2009..Multistage immunity against malaria can thus be achieved by using viral vectors recombinant for MSP-1...
- Anopheles gambiae immune responses to human and rodent Plasmodium parasite speciesYuemei Dong
W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
PLoS Pathog 2:e52. 2006..Furthermore, our data indicate that the mosquito is capable of sensing infected blood constituents in the absence of invading ookinetes, thereby inducing anti-Plasmodium immune responses...
- Identification of hot spots of malaria transmission for targeted malaria controlTeun Bousema
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
J Infect Dis 201:1764-74. 2010..This heterogeneity creates opportunities for targeted interventions but only if hot spots of malaria transmission can be easily identified...
- Chapter 5. Potential contribution of sero-epidemiological analysis for monitoring malaria control and elimination: historical and current perspectivesChris Drakeley
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Adv Parasitol 69:299-352. 2009..Here we present a review of the historical data and use it to assess the serological contribution to monitoring malaria elimination...
- Antibodies to Toxoplasma gondii in patients with schizophrenia: a meta-analysisE Fuller Torrey
Stanley Brain Research Laboratory, The Stanley Medical Research Institute, 8401 Connecticut Ave Suite 200, Chevy Chase, MD 20815, USA
Schizophr Bull 33:729-36. 2007..If an etiological association can be proven, it would have implications for the design of measures for the prevention and treatment of this disease...
- VAR2CSA domains expressed in Escherichia coli induce cross-reactive antibodies to native proteinAndrew V Oleinikov
Seattle Biomedical Research Institute, University of Washington, Seattle, USA
J Infect Dis 197:1119-23. 2008..This is the first report that E. coli-expressed VAR2CSA domains induce antibody to native VAR2CSA...
- Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSAMarion Avril
Seattle Biomedical Research Institute, 307 Westlake Ave N, Suite 500, Seattle, WA 98109 5219, USA
Infect Immun 76:1791-800. 2008..This study demonstrates that VAR2CSA contains common polymorphic epitopes that are shared between geographically diverse CSA-binding lines...
- gp63 in stable cationic liposomes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania donovaniSwati Bhowmick
Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Kolkata 700032, India
Infect Immun 76:1003-15. 2008..Our results demonstrated that stable cationic liposomes containing gp63 acted as a potent adjuvant for protein antigen to induce long-term protection against L. donovani that represents an alternative to DNA vaccination...
- Functional and immunological characterization of a Duffy binding-like alpha domain from Plasmodium falciparum erythrocyte membrane protein 1 that mediates rosettingAlfredo Mayor
Barcelona Centre for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
Infect Immun 77:3857-63. 2009..Further studies are required to elucidate the role of these antibodies in protection from malaria...
- Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genesAnja T R Jensen
Department of Medical Microbiology and Immunology, The Panum Institute, Building 24 2, Blegdamsvej 3, 2200 Copenhagen, Denmark
J Exp Med 199:1179-90. 2004..The proteins encoded by Group A var genes, such as PFD1235w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P. falciparum malaria...
- Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding proteinBrian T Grimberg
The Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America
PLoS Med 4:e337. 2007..vivax Duffy binding protein (PvDBPII) would inhibit P. vivax invasion of human erythrocytes...
- Leishmanial antigens in liposomes promote protective immunity and provide immunotherapy against visceral leishmaniasis via polarized Th1 responseSudipta Bhowmick
Infectious Diseases Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, India
Vaccine 25:6544-56. 2007..These findings suggest that an immune modulation towards Th1 is effective for both successful vaccination and immunotherapy...
- Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assayCarmen Fernandez-Becerra
Barcelona Centre for International Health Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Rosello 132, 08036 Barcelona, Spain
Malar J 9:29. 2010....
- Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for association with protection for IgG1 and disease for IgG2Francis M Ndungu
Kenya Medical Research Institute Centre for Geographical Medicine Research Coast, Kilifi, Kenya
Parasite Immunol 24:77-82. 2002..02). Conversely, elevated levels of IgG2 in relation to IgG1 and IgG3 antibodies were associated with a higher risk of developing severe malaria (P = 0.006)...
- Toxoplasma gondii infection in pregnant women in ChinaQuan Liu
Laboratory of Parasitology, Veterinary Institute, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun 130062, China
Trans R Soc Trop Med Hyg 103:162-6. 2009..In order to lower congenital infection, pregnant women need to be informed about the risk factors for toxoplasmosis...
- Safety and elicitation of humoral and cellular responses in colombian malaria-naive volunteers by a Plasmodium vivax circumsporozoite protein-derived synthetic vaccineSocrates Herrera
Instituto de Inmunologia, Universidad del Valle, Cali, Colombia
Am J Trop Med Hyg 73:3-9. 2005..These vaccines appear safe, well tolerated, and immunogenic in malaria-naive volunteers. Further optimization and development of this vaccine is being attempted to conduct phase II clinical trials...
- Immunization with H1, HASPB1 and MML Leishmania proteins in a vaccine trial against experimental canine leishmaniasisJ Moreno
WHO Collaborating Centre for Leishmaniasis, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Spain
Vaccine 25:5290-300. 2007..The results demonstrate that HASPB1 and H1 antigens in combination with Montanide were able to induce partial protection against canine leishmaniasis, even under extreme experimental challenge conditions...
- Immunogenicity and protective efficacy of recombinant vaccine based on the receptor-binding domain of the Plasmodium vivax Duffy binding protein in Aotus monkeysMyriam Arevalo-Herrera
Institute of Immunology, Universidad del Valle, Cali, Colombia
Am J Trop Med Hyg 73:25-31. 2005..Given the immunogenicity and partial protection observed, further studies are needed to optimize the PvRII vaccine formulation with adjuvants suitable for human use...
- Age-adjusted Plasmodium falciparum antibody levels in school-aged children are a stable marker of microgeographical variations in exposure to Plasmodium infectionShona Wilson
Department of Pathology, University of Cambridge, Cambridge, UK
BMC Infect Dis 7:67. 2007....
- Different antibody- and cytokine-mediated responses to Plasmodium falciparum parasite in two sympatric ethnic tribes living in MaliSalah E Farouk
Department of Immunology, Wenner Gren Institute, Stockholm University, Svante Arrheniusväg 16, S 10691 Stockholm, Sweden
Microbes Infect 7:110-7. 2005....
- Contribution of humoral immunity to the therapeutic response in falciparum malariaM Mayxay
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 65:918-23. 2001..7 [0.1-3.5] versus 2.6 [0.1-12.1]; P < 0.001). These results suggest that antimalarial antibodies may play an important supportive role in the therapeutic response to antimalarial drugs during acute falciparum malaria...
- Rapid assessment of malaria transmission using age-specific sero-conversion ratesLaveta Stewart
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
PLoS ONE 4:e6083. 2009..This study evaluated SCR generated from samples collected from health facility attendees as a tool for a rapid assessment of malaria transmission intensity...
- Toxoplasma and reaction time: role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphismM Novotna
Department of Parasitology, Charles University, Prague 128 44, Czech Republic
Parasitology 135:1253-61. 2008..Moreover, an unequal prevalence of toxoplasmosis in different countries could explain pronounced differences in frequencies of RhD-negative phenotype in geographically distinct populations...
- Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control studyJaroslav Flegr
Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic
BMC Infect Dis 2:11. 2002..It is not know, however, whether the changes observed in laboratory influence the performance of subjects in real-life situations...
- Leishmune vaccine blocks the transmission of canine visceral leishmaniasis: absence of Leishmania parasites in blood, skin and lymph nodes of vaccinated exposed dogsF S Nogueira
Faculdade de Medicina Veterinaria e Zootecnia, Universidade Estadual Paulista Julio de Mesquita Filho, UNESP Botucatu Distrito Rubião Jr s n Botucatu SP CEP 18600 000, Brazil
Vaccine 23:4805-10. 2005..006) being strong markers of infectiousness. The absence of symptoms and of evidence of Leishmania DNA and parasites in Leishmune-vaccinated animals indicates the non-infectious condition of the Leishmune-vaccinated dogs...
- Naturally acquired Duffy-binding protein-specific binding inhibitory antibodies confer protection from blood-stage Plasmodium vivax infectionChristopher L King
Case Western Reserve University Center for Global Health and Diseases, Cleveland, OH 44106
Proc Natl Acad Sci U S A 105:8363-8. 2008..vivax strains characterized by six diverse PvDBPII haplotypes. These observations demonstrate a functional correlate of protective immunity in vivo and provide support for developing a vaccine against P. vivax malaria based on PvDBPII...
- Antibodies to a recombinant glutamate-rich Plasmodium falciparum protein: evidence for protection of individuals living in a holoendemic area of LiberiaB Hogh
Department of Infection Immunology, Statens Seruminstitut, Copenhagen, Denmark
Am J Trop Med Hyg 46:307-13. 1992..The data provide indirect evidence for a protective role of antibodies reacting with recombinant GLURP489-1271 as well as with the synthetic peptide (EENV)6 from the Pf155/RESA...
- Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein 1-duffy binding-like 1 alpha domainKirsten Moll
Microbiology and Tumorbiology Center, Karolinska Institutet and Swedish Institute for Infectious Disease Control, Nobels vag 16, 171 77 Stockholm, Sweden
Infect Immun 75:211-9. 2007..These results strongly support the use of the DBL1 alpha domain in the development of a vaccine targeting severe malaria...
- The effect of intermittent preventive treatment during pregnancy on malarial antibodies depends on HIV status and is not associated with poor delivery outcomesElisa Serra-Casas
Barcelona Centre for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
J Infect Dis 201:123-31. 2010..However, studies reporting the effect of IPTp on malaria-specific immunity are scarce and are based on findings in human immunodeficiency virus (HIV)-negative primigravidae...
- [Biotic and abiotic determinants of seroprevalence of antibodies against Trypanosoma cruzi in Palmar de Bravo, Puebla, Mexico]Francisca Sosa-Jurado
Hospital de Especialidades, Centro Medico Nacional Manuel Avila Camacho, Instituto Mexicano del Seguro Social, Puebla, Puebla, Mexico
Salud Publica Mex 46:39-48. 2004..To establish the relationship between seroprevalence for antibodies against Trypanosoma cruzi and its relationship with biotic and abiotic factors...
- DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protectionL Planelles
, , CSIC, 18001 Granada, Spain
Infect Immun 69:6558-63. 2001..Moreover, protection against the parasite challenge was observed after immunization with the chimeric gene...
- Malaria transmission and naturally acquired immunity to PfEMP-1K P Piper
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
Infect Immun 67:6369-74. 1999..This regulation may be achieved in two ways: (i) by controlling asexual proliferation and density and (ii) by affecting gametocyte maturation...
- Decreased level of psychobiological factor novelty seeking and lower intelligence in men latently infected with the protozoan parasite Toxoplasma gondii Dopamine, a missing link between schizophrenia and toxoplasmosis?Jaroslav Flegr
Department of Parasitology, Charles University, Vinicna 7, 128 44, Prague, Czech Republic
Biol Psychol 63:253-68. 2003..003) and lower probability of achieving a higher education (P(2)<0.0000). Decrease of NS suggests that the increase of dopamine in brain of infected subjects can represent a missing link between toxoplasmosis and schizophrenia...
- A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infectionT Yoneto
Department of Allergology and Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
J Immunol 166:6236-41. 2001..These results suggest that FcR-mediated Ab-dependent phagocytosis, which is located downstream of IFN-gamma production, is important as an effector mechanism to eliminate PRBC in blood-stage P. berghei XAT infection...
- Cytokine expression during the outcome of canine experimental infection by Leishmania infantumGabriela M Santos-Gomes
Unidade de Leishmanioses, Centro de Malaria e Outras Doencas Tropicais, Instituto de Higiene e Medicina Tropical IHMT, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisbon, Portugal
Vet Immunol Immunopathol 88:21-30. 2002..The predominance of a Th1 type response for a relatively short period indicates that these cytokines are required to control the infection delaying the appearance of progressive disease...
- Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variantsP C Bull
Kenya Medical Research Institute CGMRC, Kilifi Unit, Kilifi, Kenya
Infect Immun 67:733-9. 1999..These results support the idea that preexisting anti-PfEMP1 antibodies can select the variants that are expressed during a new infection and may suggest the existence of a dominant subset of PfEMP1 variants...
- Protection against clinical malaria by heterologous immunoglobulin G antibodies against malaria-infected erythrocyte variant surface antigens requires interaction with asymptomatic infectionsSamson M Kinyanjui
Kenya Medical Research Institute Centre for Geographic Medicine Research Coast, Kilifi, Kenya
J Infect Dis 190:1527-33. 2004..These results support previous findings and underline the importance of considering the parasitological status of study participants when examining the role that immune responses to VSAs and other malaria antigens play...
- Seroepidemiological evidence for a relationship between Neospora caninum infections in dogs and cattleW Wouda
Animal Health Service, Drachten, The Netherlands
Int J Parasitol 29:1677-82. 1999..Since dogs have been shown to be definitive hosts of N. caninum, cattle may be infected by exposure to canine oocysts. Further research is needed to find out whether and how dogs may acquire the infection from cattle...
- Relationship between human immunodeficiency virus type 1 coinfection, anemia, and levels and function of antibodies to variant surface antigens in pregnancy-associated malariaAnthony Jaworowski
Centre for Virology, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia
Clin Vaccine Immunol 16:312-9. 2009..In multigravid pregnant women with malaria, impaired serum opsonic activity may contribute to anemia and possibly to the decreased immunity to pregnancy-associated malaria associated with HIV-1...
- Antibodies to Toxoplasma gondii in individuals with first-episode schizophreniaR H Yolken
Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 4933, USA
Clin Infect Dis 32:842-4. 2001..We found that the individuals with first-episode schizophrenia had significantly increased levels of IgG, IgM, and IgA class antibodies to Toxoplasma proteins, as compared with the control subjects...
- Growth of Plasmodium falciparum induces stage-dependent haemichrome formation, oxidative aggregation of band 3, membrane deposition of complement and antibodies, and phagocytosis of parasitized erythrocytesG Giribaldi
Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy
Br J Haematol 113:492-9. 2001....
- A region of Plasmodium falciparum antigen Pfs25 that is the target of highly potent transmission-blocking antibodiesA W Stowers
Malaria Vaccine Development Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
Infect Immun 68:5530-8. 2000..Vaccination strategies that target antibody response towards this domain may improve the efficacy of future transmission-blocking vaccines...
- Plasmodium falciparum: immunogenicity of alum-adsorbed clinical-grade TBV25-28, a yeast-secreted malaria transmission-blocking vaccine candidateM M Gozar
Malaria Vaccines Section, National Institutes of Health, Bethesda, Maryland 20892
Exp Parasitol 97:61-9. 2001..The apparent decrease in potency of clinical-grade TBV25-28 in rabbits appears to reflect an enhancement in potency of clinical-grade TBV25H in a new formulation rather than simply a species difference in immunogenicity of TBV25-28...
- High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasionClemens H M Kocken
Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
Infect Immun 70:4471-6. 2002..falciparum by immunofluorescence. In addition, purified immunoglobulin G from immunized animals strongly inhibited invasion of red blood cells by homologous and, to a somewhat lesser extent, heterologous P. falciparum...
- Comparison of liposome based antigen delivery systems for protection against Leishmania donovaniSwati Bhowmick
Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Jadavpur, Kolkata 700032, India
J Control Release 141:199-207. 2010..Cationic MLV when used as adjuvant with protein antigens induced sustained Th1 immunity. Adjuvant potential of cationic MLV can be utilized to design subunit vaccines...
- Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolatesAyman Khattab
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Malar J 3:21. 2004....
- Plasmodium falciparum: use of a NANP19 antibody-test for the detection of infection in non-immune travellersM Knappik
Department of Infectious Diseases and Tropical Medicine, University of Munich, Munich, Germany
Trop Med Int Health 7:652-6. 2002..falciparum. It may also be useful for the determination of the efficacy of malaria chemoprophylaxis for inhibiting outbreak of disease...
- Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasisJ Alexander
Department of Immunology, University of Strathclyde, Glasgow, GB
Eur J Immunol 30:2935-43. 2000..These results demonstrate that IL-4 has an important role in effective anti-leishmanial chemotherapy which seems to be related to modulation of IFN-gamma production...
- Epidemiologic aspects of the malaria transmission cycle in an area of very low incidence in BrazilCrispim Cerutti
Department of Social Medicine, Biomedical Center, Federal University of Espirito Santo, Maruípe, Vitoria ES, Brazil
Malar J 6:33. 2007..Extra-Amazonian autochthonous Plasmodium vivax infections have been reported in mountainous regions surrounded by the Atlantic Forest in Espírito Santo state, Brazil...
- Anti-NANP antibody and treatment efficacy in patients with acute uncomplicated falciparum malaria attacksV Robert
Institut de Recherche pour le Développement ex ORSTOM, Laboratoire de Paludologie, Dakar, Senegal
Parasite Immunol 22:589-93. 2000....
- Immune Pathways as Prerequisites for Adjuvants' EfficacyGeorge Hui; Fiscal Year: 2004....
- Translation Research in Plasmodium vivaxSocrates Herrera; Fiscal Year: 2005..abstract_text> ..
- MOLECULAR TARGETS OF BLOCKING MALARIA TRANSMISSIONJoseph Vinetz; Fiscal Year: 2005....
- Leptospirosis Transmission in the Peruvian AmazonJoseph Vinetz; Fiscal Year: 2006....
- Microarray Analysis of Leptospiral GenomesJoseph Vinetz; Fiscal Year: 2007..unreadable] [unreadable]..
- International Leptospirosis Society Meeting 2007Joseph Vinetz; Fiscal Year: 2007..unreadable] Outcome of the meeting will be assessed by peer-reviewed publication and trainee publication and[unreadable] career advancement. ..
- Genetics of Innate Immunity in Human Leptospirosis in BrazilJoseph Vinetz; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- MOLECULAR TARGETS OF BLOCKING MALARIA TRANSMISSIONJoseph M Vinetz; Fiscal Year: 2010..falciparum chitinase, PfCHTI, and provide the scientific basis for developing novel potential approaches to interrupting malaria transmission at the vertebrate host-mosquito vector interface. ..
- Human Reservoirs of Plasmodium vivax Transmission in the Peruvian AmazonJoseph M Vinetz; Fiscal Year: 2010..vivax, and provide a rational basis for determining strategies to implement and deploy new transmission- blocking vaccines as one approach towards the future elimination of P. vivax malaria from the Amazon basin. ..
- Comparison of US and European Babesia divergens IsolatesPatricia Holman; Fiscal Year: 2004..The molecular aspects may provide information that will be useful in future efforts to devise diagnostic tests. ..
- A CHEMICALLY SYNTHETIC ANTI-TOXIC VACCINE AGAINST MALARILouis Schofield; Fiscal Year: 2002..Clinical immunity to malaria is acquired considerably earlier than anti-parasite immunity, and it is possible that this is mediated by anti-toxin mechanisms. ..
- High Throughput Analysis of Malarial Surface AntigensANDREW OLEINIKOV; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- IMMUNOBIOLOGY OF MALARIA GLYCOSYLPHOSPHATIDYLINOSITOLLouis Schofield; Fiscal Year: 2001..These areas are central to understanding the host/parasite interaction and the development of effective vaccines to several protozoal pathogens. ..
- MATERNAL MALARIA--PARASITE ADHESION AND ANTIBODIESPatrick Duffy; Fiscal Year: 2001..Further, the delineation of binding domains and B cell epitopes will provide the basis to design an anti-adhesion vaccine to protect primigravid and other women susceptible to placental infection with the CSA-binding parasites. ..
- Abnormalities of Mitochondria in Chagasic MyocarditisNisha Garg; Fiscal Year: 2003..The proposed studies will determine the pathophysiological contribution of host mitochondrial abnormalities in the progression of chagas disease. ..
- B.abortus-based vaccine against viral hemorrhagic feversRamesh Vemulapalli; Fiscal Year: 2004..abstract_text> ..
- Pregnancy-Associated Horomones and Immune to MalariaDiane Taylor; Fiscal Year: 2006....
- Rapid and Simple CSF Tests for Neurosyphillis DiagnosisChristina Marra; Fiscal Year: 2006..The results of this study will be used to design field trials in the areas of greatest need. ..
- MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIESArturo Casadevall; Fiscal Year: 2006..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
- Role of cysteine proteases in malaria transmissionKIM WILLIAMSON; Fiscal Year: 2006..In addition to increasing our understanding of the genes involved, this information can be used to direct the design of cysteine protease inhibitors that will effectively block malaria transmission. ..
- Real-time PCR diagnostic kit for Giardia and CryptosporidiumEric Houpt; Fiscal Year: 2006..A Phase II application is anticipated to validate the final diagnostic test product against immunoassay for an FDA 501 (k) medical device application. [unreadable] [unreadable] [unreadable]..
- Gene Polymorphisms Predisposing to Infectious DiarrheaPablo Okhuysen; Fiscal Year: 2007..abstract_text> ..
- Prenatal factors and risk of autism in a Finnish national birth cohortALAN STEWART BROWN; Fiscal Year: 2010....
- Mucosal immune regulation in murine amebic colitisEric Houpt; Fiscal Year: 2007..The comprehensive approach in training and research laid out in this research proposal will guide the applicant towards his goal of being an independent investigator in immunoparasitology. ..
- Targeted DNA extraction for Tuberculosis PCR from sputumEric Houpt; Fiscal Year: 2007..The most sensitive procedure will be taken in Phase II and adapted to high-throughput DNA extraction platforms and compared against the standard E- MTD assay. [unreadable] [unreadable] [unreadable]..
- Prenatal Factors and Risk of Bipolar DisorderALAN STEWART BROWN; Fiscal Year: 2010....
- Non-replicative Vaccine for Human BrucellosisRamesh Vemulapalli; Fiscal Year: 2011..At present there is no vaccine available for prevention of brucellosis in humans. Research proposed in this application focuses on developing a highly effective and safe Brucella vaccine for human use. ..
- Plasmodium carbohydrate receptors in Anopheles gambiaeRHOEL DAVID DINGLASAN; Fiscal Year: 2008..This line of experimentation will open up new avenues of research through the basic, glycobiological analysis of the mosquito midgut biology. [unreadable] [unreadable] [unreadable]..
- Mosquito injection of Plasmodium sporozoites into skinJerome Vanderberg; Fiscal Year: 2009....
- Mouse Strain dependent innate resistance to intestinal amebiasisEric Houpt; Fiscal Year: 2009....
- Cell adhesion molecules in cerebral malaria.Henri van der Heyde; Fiscal Year: 2005..berghei malaria. We will test whether inhibition of an intracellular signaling pathway (specifically NF-?B) abrogates cerebral malaria and respiratory distress by preventing increased CAM expression and T cell adherence to endothelium. ..
- Innate Immunity Driven Th1/Th2 bias in LeishmaniasisKeith Nelson; Fiscal Year: 2005..abstract_text> ..
- The Role of Pesticide Dispersion Within Texas Watershed*James Thompson; Fiscal Year: 2004..It is anticipated that the results produced will provide the preliminary data needed to continue definitive investigations under the auspices of subsequent R01 funding. ..
- Novel Methods to Access Brain Function in HIV-1Christina Marra; Fiscal Year: 2003..abstract_text> ..
- ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASIONChristina Marra; Fiscal Year: 2004..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..
- Pathogenesis of falciparum malaria in infancyPatrick Duffy; Fiscal Year: 2004..Identifying new therapies for children is an urgent public health goal, but is not a funding priority for the United States Department of Defense. ..
- Diverse Neutralizing Human Monoclonal Antibodies to CMVANGRAY KANG; Fiscal Year: 2003..The phase II SBIR proposal may initially require the leneration of a larger panel of antibodies, based on the success of phase I. ..
- HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSESPeter Krause; Fiscal Year: 2001..The density of deer will be estimated in each site. This proposed effort will help define the health burden imposed on people residing in proximity to deer and will contribute to diagnosis and case-management of apparent Lyme disease. ..
- B CELL DEPENDENT IMMUNITY TO TOXOPLASMA GONDIILawrence Johnson; Fiscal Year: 2004..Also, the role of B cells in protection against congenital T. gondii infection and the influence of Toxoplasma-specific antibodies on the resistance of mice infected as neonates will be analyzed. ..
- IL 12 RESPONSIVENESS DURING L AMAZONENSIS INFECTIONDouglas Jones; Fiscal Year: 2004..The efforts of this proposal will have direct application to the development of more effective immunomodulatory regimes for Leishmania and other infectious diseases. ..
- TH2 BIAS EFFECT ON MALARIAL IMMUNITY IN CAMEROONDiane Taylor; Fiscal Year: 2002..The hope is that one or a combination of these identifiable immune responses will correlate with susceptibility/resistance and can be used to predict the immune status of people in endemic populations. ..
- MOLECULAR GENETIC ANALYSIS OF MALARIA ANTIGENSKIM WILLIAMSON; Fiscal Year: 2004..The regulatory regions identified will be used to test for nuclear factor binding, to identify similar regions in other genes, and to construct transformation plasmids containing stage-specific, inducible promoters. ..
- Falciparum malaria invasion ligand DNA/protein vaccineDavid Narum; Fiscal Year: 2002..S. military has lost more person days to malaria than to bullets (Beadle and Hoffman, 1993). A vaccine against malaria would have enormous domestic and international commercial value. ..
- Mining slime mold for susceptibility genes to fungiArturo Casadevall; Fiscal Year: 2005..discoideum system will lead to the identification of genetic pathways that are not immediately obvious from standard fungal-macrophage experiments. ..
- EFFECT OF MORPHINE ON IMMUNE RESISTANCE TO T GONDIILawrence Johnson; Fiscal Year: 2002..Together, these studies will provide a comprehensive immunological foundation upon which to build detailed further analyses of the effects of an opioid drug on immunity to opportunistic infection. ..
- Serologic Studies of Prenatal Factors in SchizophreniaAlan Brown; Fiscal Year: 2002..For this purpose, we shall quantify levels of these cytokines in 100 SSD cases and their respective matched controls, and compare these levels between the groups. ..
- Regulation of innate immunity to infectionLawrence Johnson; Fiscal Year: 2005..Thus, the proposed studies will form a foundation on which to build future studies to examine how regulation of innate immunity impacts acquired immunity to infection and vaccination. ..
- Vaccine Induced Mucosal Protection Against TB InfectionDANIEL HOFT; Fiscal Year: 2005..Prime/boosting strategies found to prevent BCG infection after aerosol challenges will be studied for the ability to prevent infection with virulent M. tuberculosis by aerosol challenge. ..
- IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYAChandy John; Fiscal Year: 2002..falciparum antigens to susceptibility to infection and disease is important in the evaluation of these antigens as malaria vaccine candidates. ..
- DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIAAlan Brown; Fiscal Year: 2004....
- DEVELOPMENT OF THE HBCAG AS A VACCINE CARRIER PLATFORMDavid Milich; Fiscal Year: 2008..abstract_text> ..
- Immunogenicity of Synthetic Peptide Malaria VaccinesElizabeth Nardin; Fiscal Year: 2009..abstract_text> ..
- TRYPANOSOMA CRUZI MUCOSAL & SYSTEMIC PROTECTIVE IMMUNITYDANIEL HOFT; Fiscal Year: 2008..Chemokine and/or integrin receptor expression will be studied by flow cytometry and RT-Real-Time PCR, and the in vivo effects of defective chemokine and integrin binding and/or signaling will be evaluated. [unreadable] [unreadable]..
- Multiplex bead-PCR diagnosis for AIDS diarrheaEric Houpt; Fiscal Year: 2007..Finally, syndrome-based multiplex diagnosis is the platform of the future for clinical microbiology, and if this assay works on stool it should work on sputum, blood, or spinal fluid. [unreadable] [unreadable] [unreadable]..
- Development of Preventative and Therapeutic HCV VaccinesDavid Milich; Fiscal Year: 2006..It is anticipated that a NS3/4A DNA vaccine may be used for prophylactic or therapeutic applications either alone or in combination with E2-WHcAg hybrid particles. ..
- T Cell Epitopes of the Malaria Circumsporozoite ProteinsElizabeth Nardin; Fiscal Year: 2007..falciparum vaccines and (2) evaluation of anti-P, falciparum repeat immune responses elicited in human volunteers immunized with malaria vaccines. ..
- Immunoglobulin Allotypes in Hepatitis C Virus InfectionJANARDAN PANDEY; Fiscal Year: 2008..Results of this investigation will advance our understanding of the role of host genetic factors in clearance and persistence of hepatitis C virus infection. ..
- Retrovectors for Intron-Enhanced Protein ExpressionMichael Imboden; Fiscal Year: 2005..abstract_text> ..
- Evaluation of High-Capacity Adenovectors in the EyeJoseph Bruder; Fiscal Year: 2006..The long-term goal of this proposal is the clinical testing and commercialization of PEDF expressing HC vector for the treatment of AMD and other ocular neovascular diseases. [unreadable] [unreadable]..
- COMPLEMENT REGULATION IN TRYPANOSOMA CRUZIKaren Norris; Fiscal Year: 2005..The successful completion of these aims will provide the first functional and immunological evaluation of a critical virulence factor of T. cruzi and provide information and reagents for the use of CRP as a vaccine candidate. ..
- Immunologic interaction of schistomiasis & acute malariaKirsten Lyke; Fiscal Year: 2005..abstract_text> ..
- Development of rapid detection tests for B pseudomalleiRaymond Houghton; Fiscal Year: 2006..These tools will be invaluable in detecting and monitoring acute and chronic B. pseudomallei infections both in endemic areas as well as following a bioterrorist attack. ..
- Pneumocystis and COPD in a Simian Model of AIDSKaren Norris; Fiscal Year: 2009..abstract_text> ..
- Immune response to Pneumocystis in simian model of AIDSKaren Norris; Fiscal Year: 2009....
- PNEUMOCYSTIS CARINII PNEUMONIA MODEL IN RHESUS MACAQUESKaren Norris; Fiscal Year: 2002..carinii and determine the relevance of the nonhuman primate model, thus providing the means to study many aspects of PCP previously unapproachable due to the limitations of other animal models. ..
- Rapid antigen detection test for Dengue infectionRaymond Houghton; Fiscal Year: 2008..This virus is endemic in many tropical and sub-tropical regions of the world and can be fatal. It is also listed as a bioterrorism agent. Early diagnosis could lead to improved treatment outcomes. [unreadable] [unreadable] [unreadable]..
- T. cruzi immune evasion factors and vaccine designKaren Norris; Fiscal Year: 2008..No vaccine is currently available to prevent or treat Chagas' disease and the proposed studies will test two vaccine candidates in experimental models. [unreadable] [unreadable] [unreadable]..