Summary: PLANT EXTRACTS and compounds, primarily ISOFLAVONES, that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.

Top Publications

  1. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
  2. ncbi Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States
    S L Teitelbaum
    Mount Sinai School of Medicine, Department of Community and Preventive Medicine, 1 Gustave Levy Place, P O Box 1043, New York, NY 10029, USA
    Environ Res 106:257-69. 2008
  3. pmc Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls
    Mary S Wolff
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Environ Health Perspect 118:1039-46. 2010
  4. ncbi The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, 87030 Rende CS, Italy
    J Biol Chem 279:27008-16. 2004
  5. ncbi Estrogenic activities of isoflavones and flavones and their structure-activity relationships
    Sun Young Choi
    Food Function Research Group, Korea Food Research Institute, Gyeonggi Do, Republic of Korea
    Planta Med 74:25-32. 2008
  6. ncbi Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium
    P Diel
    , Deutsche Sporthochschule, , Germany
    Hum Reprod 16:997-1006. 2001
  7. pmc The pros and cons of phytoestrogens
    Heather B Patisaul
    Department of Biology, NC State University, Raleigh, NC 27695, USA
    Front Neuroendocrinol 31:400-19. 2010
  8. ncbi The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell-mediated LDL modification
    Juliana Hwang
    School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Free Radic Biol Med 34:1271-82. 2003
  9. ncbi Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells
    Stefan O Mueller
    Molecular Toxicology, Institute of Toxicology, Merck KGaA, Darmstadt, Germany
    Toxicol Sci 80:14-25. 2004
  10. ncbi Hormonal action of plant derived and anthropogenic non-steroidal estrogenic compounds: phytoestrogens and xenoestrogens
    T Lorand
    Department of Biochemistry and Medical Chemistry, University of Pecs, Medical School, Pecs, Hungary
    Curr Med Chem 17:3542-74. 2010

Detail Information

Publications320 found, 100 shown here

  1. ncbi Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    G G Kuiper
    Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
    Endocrinology 139:4252-63. 1998
    ..In this study, we investigated the estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ER alpha or ER beta protein, and in a transient gene expression assay using ..
  2. ncbi Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States
    S L Teitelbaum
    Mount Sinai School of Medicine, Department of Community and Preventive Medicine, 1 Gustave Levy Place, P O Box 1043, New York, NY 10029, USA
    Environ Res 106:257-69. 2008
    Exposure to endocrine disruptors (EDs), including some phthalates, phytoestrogens and phenols can be quantified using biomarkers of exposure...
  3. pmc Investigation of relationships between urinary biomarkers of phytoestrogens, phthalates, and phenols and pubertal stages in girls
    Mary S Wolff
    Mount Sinai School of Medicine, New York, NY 10029, USA
    Environ Health Perspect 118:1039-46. 2010
    ..Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by steroids and gonadotropins...
  4. ncbi The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells
    Marcello Maggiolini
    Department of Pharmaco Biology, University of Calabria, 87030 Rende CS, Italy
    J Biol Chem 279:27008-16. 2004
    ..and ER-negative SKBR3 breast cancer cells, we have discovered that 17beta-estradiol (E2), and the two major phytoestrogens, genistein and quercetin, stimulate c-fos expression through ERalpha as well as through an ER-independent ..
  5. ncbi Estrogenic activities of isoflavones and flavones and their structure-activity relationships
    Sun Young Choi
    Food Function Research Group, Korea Food Research Institute, Gyeonggi Do, Republic of Korea
    Planta Med 74:25-32. 2008
    ..89 and q2 = 0.83). The prediction of estrogenicity with regard to ER beta reveals a positive correlation with the AlogP and Hbond acceptors, and a negative correlation with RadOfGyration (r2 = 0.77 and q2 = 0.72)...
  6. ncbi Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium
    P Diel
    , Deutsche Sporthochschule, , Germany
    Hum Reprod 16:997-1006. 2001
  7. pmc The pros and cons of phytoestrogens
    Heather B Patisaul
    Department of Biology, NC State University, Raleigh, NC 27695, USA
    Front Neuroendocrinol 31:400-19. 2010
    b>Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably soy...
  8. ncbi The phytoestrogen equol increases nitric oxide availability by inhibiting superoxide production: an antioxidant mechanism for cell-mediated LDL modification
    Juliana Hwang
    School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Free Radic Biol Med 34:1271-82. 2003
    ..Decreased O(2)(-*) production resulted in increased free NO levels (but not total NO production) indicating that decreased reactions between O(2)(-*) and NO are an outcome of equol's antioxidant activity in cell culture...
  9. ncbi Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells
    Stefan O Mueller
    Molecular Toxicology, Institute of Toxicology, Merck KGaA, Darmstadt, Germany
    Toxicol Sci 80:14-25. 2004
    b>Phytoestrogens exert pleiotropic effects on cellular signaling and show some beneficial effects on estrogen-dependent diseases...
  10. ncbi Hormonal action of plant derived and anthropogenic non-steroidal estrogenic compounds: phytoestrogens and xenoestrogens
    T Lorand
    Department of Biochemistry and Medical Chemistry, University of Pecs, Medical School, Pecs, Hungary
    Curr Med Chem 17:3542-74. 2010
    Herbivorous and omnivorous vertebrates have evolved in the presence of a variety of phytoestrogens, i.e., plant-derived compounds that can mimic, modulate or disrupt the actions of endogenous estrogens...
  11. ncbi A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy
    M G Glazier
    Department of Family Practice and Community Medicine, University of Pennsylvania, Second Floor, Gates Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    Arch Intern Med 161:1161-72. 2001
    ..Because of this, there is increasing interest in the use of plant-derived estrogens, also known as phytoestrogens. This article reviews the evidence for the potential of phytoestrogens, either in dietary or supplemental form,..
  12. ncbi Lignans and human health
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center, Finland
    Crit Rev Clin Lab Sci 44:483-525. 2007
    ..The source of the lignans seems to play a role because other factors in the food obviously participate in the protective effects. The results are promising, but much work is still needed in this area of medicine...
  13. ncbi S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora
    Kenneth D R Setchell
    Division of Pathology, Clinical Mass Spectrometry, Cincinnati Children s Hospital Medical Center, and the Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati 45229, OH, USA
    Am J Clin Nutr 81:1072-9. 2005
    ..Equol, unlike the soy isoflavones daidzein or genistein, has a chiral center and therefore can occur as 2 distinct diastereoisomers...
  14. ncbi Phyto-oestrogens and cancer
    Herman Adlercreutz
    Institute for Preventive Medicine, Nutrition, and Cancer, Folkhalsan Research Center, Division of Clinical Chemistry, University of Helsinki, Helsinki, Finland
    Lancet Oncol 3:364-73. 2002
    ..Whether these observed protective effects are caused by the presence of dietary phyto-oestrogens, or whether they are merely indicators of a healthy diet in general, has not been established...
  15. ncbi Behavioral changes in fish exposed to phytoestrogens
    Ethan D Clotfelter
    Department of Biology, Amherst College, Amherst, MA 01002, USA
    Environ Pollut 144:833-9. 2006
    We investigated the behavioral effects of exposure to waterborne phytoestrogens in male fighting fish, Betta splendens...
  16. ncbi Dietary phytoestrogens and breast cancer risk
    Lital Keinan-Boker
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands
    Am J Clin Nutr 79:282-8. 2004
    A high intake of phytoestrogens, particularly isoflavones, has been suggested to decrease breast cancer risk. Results from human studies are inconclusive.
  17. ncbi Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption
    R H Waring
    School of Biosciences, University of Birmingham, Birmingham, United Kingdom
    J Steroid Biochem Mol Biol 108:213-20. 2008
    ..Endocrine disrupting effects in man may be multifactorial when components from both the diet and the environment act at the same point in steroid metabolism...
  18. pmc Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study
    Elisa V Bandera
    Cancer Prevention and Control Program Division of Surgical Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    BMC Womens Health 11:40. 2011
    ..While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention...
  19. ncbi Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Bioorg Med Chem 16:6891-902. 2008
  20. pmc A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3β protein-dependent activation of the Wnt/β-catenin signaling pathway
    Kanit Bhukhai
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    J Biol Chem 287:36168-78. 2012
    ..Our findings provide a scientific rationale for using C. comosa as a dietary supplement to prevent bone loss in postmenopausal women...
  21. ncbi Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial
    Yuko Tousen
    Food Function and Labeling Program, National Institute of Health and Nutrition, Tokyo, Japan
    Menopause 18:563-74. 2011
    ..However, results from clinical trials have not been published. The aim of this study was to investigate the effects of equol on bone metabolism and serum sex and thyroid hormone levels in postmenopausal Japanese women...
  22. ncbi Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons
    Lixia Zhao
    Department of Molecular Pharmacology and Toxicology and Neuroscience Program, Pharmaceutical Sciences Center, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA
    Exp Biol Med (Maywood) 227:509-19. 2002
    ..b>Phytoestrogens have been proposed as potential alternatives to ERT...
  23. ncbi Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity
    D Xin
    Institute of Traditional Chinese Medicine Research, Tianjin University of Traditional Chinese Medicine, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin 300193, PR China
    Phytomedicine 17:126-31. 2010
    ..In conclusion, both ER subtype-selective and nonselective activities in compounds derived from PCL suggested that PCL could be a new source for selective estrogen-receptor modulators...
  24. pmc Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Horm Behav 55:319-28. 2009
    ..Isoflavone phytoestrogens, also potent but less selective ERbeta agonists, have also been shown to influence anxiety in multiple species ..
  25. ncbi Modulation of soy isoflavones bioavailability and subsequent effects on bone health in ovariectomized rats: the case for equol
    J Mathey
    Groupe Osteoporose, U3M, INRA Theix, Saint Genes Champanelle, France
    Osteoporos Int 18:671-9. 2007 benefits in a range of hormonal conditions, such as osteoporosis, due to their high content in phytoestrogens. Because equol, the main metabolite from soy isoflavones, is thought to be powerful, the present study was ..
  26. ncbi Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors
    Masatomo Suetsugi
    Department of Surgical Research and Division of Information Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Mol Cancer Res 1:981-91. 2003
    ..our laboratory recently performed virtual ligand screening on ERRalpha that predicted flavone and isoflavone phytoestrogens to be ligands of this receptor...
  27. ncbi Molecular aspects of phytoestrogen selective binding at estrogen receptors
    Joseph V Turner
    School of Medicine, Rural Clinical Division, The University of Queensland, Locked Bag 9009, Toowoomba DC, Brisbane, QLD 4350, Australia
    J Pharm Sci 96:1879-85. 2007
    b>Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health...
  28. pmc Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms
    Wipawee Winuthayanon
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Environ Health Perspect 117:1155-61. 2009
    ..Diarylheptanoids isolated from Curcuma comosa Roxb. have been recently identified as phyto estrogens. However, the mechanism underlying their actions has not yet been identified...
  29. ncbi Developing phytoestrogens for breast cancer prevention
    Mandy M Liu
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Anticancer Agents Med Chem 12:1306-13. 2012
    ..Chemoprevention using phytoestrogens (PEs) for breast cancer may be a valid strategy...
  30. ncbi Dietary phytoestrogens and health
    Teresa Cornwell
    Biotech Center, Cook College, Rutgers University, New Brunswick, NJ, 08901 8520, USA
    Phytochemistry 65:995-1016. 2004
    The interest in the potential health effects of dietary phytoestrogens has increased with the findings that hormone replacement therapy is not as safe or effective as previously thought...
  31. pmc Identification of the potent phytoestrogen glycinol in elicited soybean (Glycine max)
    Stephen M Boue
    Southern Regional Research Center, United States Department of Agriculture, New Orleans, Louisiana 70179, USA
    Endocrinology 150:2446-53. 2009
    ..Taken together, these results suggest for the first time that glycinol is estrogenic and may represent an important component of the health effects of soy-based foods...
  32. ncbi Interaction of phytoestrogens with estrogen receptors alpha and beta (II)
    Keiko Morito
    Department of Molecular and Cellular Biology, Faculty of Pharmaceutical Sciences, Kanazawa University, Ishikawa, Japan
    Biol Pharm Bull 25:48-52. 2002
    ..The results show that methylation or glucosidation of isoflavones generally inhibits their phytoestrogenic activities...
  33. ncbi Soy, phytoestrogens and metabolism: A review
    Christopher R Cederroth
    Department of Genetic Medicine and Development, University of Geneva Medical School, Switzerland
    Mol Cell Endocrinol 304:30-42. 2009
    Of any plant, soy contains the largest concentration of isoflavones, a class of phytoestrogens. Phytoestrogens are structurally similar to estradiol and mimic its effects...
  34. pmc Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems
    C A Frye
    Department of Psychology, The University at Albany SUNY, Albany, NY 12222, USA
    J Neuroendocrinol 24:144-59. 2012
    ..bisphenol A), pharmaceuticals (i.e. diethylstilbestrol; 17α-ethinylestradiol) or dietary components (such as phytoestrogens)...
  35. ncbi Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng
    Robbie Y K Chan
    The Open Laboratory of Chirotechnology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, Peoples Republic of China
    J Clin Endocrinol Metab 87:3691-5. 2002
    ..Our results indicate that ginsenosides Rg1 has estrogen-like activity and should be classified as a novel class of potent phytoestrogen...
  36. ncbi Method of defining equol-producer status and its frequency among vegetarians
    Kenneth D R Setchell
    Sanitarium Development and Innovation, Cooranbong, NSW 2265, Australia
    J Nutr 136:2188-93. 2006
  37. ncbi Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S.women: the Framingham study
    Miriam J J de Kleijn
    Julius Center for General Practice and Patient Oriented Research, University Medical Center, Utrecht, The Netherlands
    J Nutr 132:276-82. 2002
    ..55 points (95% CI, -0.82 to -0.28). In conclusion, high intake of phytoestrogens in postmenopausal women appears to be associated with a favorable metabolic cardiovascular risk profile.
  38. pmc Effects of genistein aglycone in osteoporotic, ovariectomized rats: a comparison with alendronate, raloxifene and oestradiol
    A Bitto
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    Br J Pharmacol 155:896-905. 2008
    ..To clarify this, we investigated the effects of genistein compared with alendronate, raloxifene and oestradiol in an animal model of established osteoporosis...
  39. ncbi Phytoestrogens: recent developments
    Paul Cos
    Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
    Planta Med 69:589-99. 2003
    b>Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen-like biological activity. Based on their chemical structure, phytoestrogens can be classified into four main groups, i. e...
  40. ncbi Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens
    B Gutendorf
    Department of Toxicology, Medical School, University of Hamburg, Vogt Koelln Strasse 30, D 22527 Hamburg, Germany
    Toxicology 166:79-89. 2001
    ..The phytoestrogens showed a preference to bind to ER-beta, but only genistein showed a much lower activity in the E-Screen (..
  41. ncbi Antioxidant efficacy of phytoestrogens in chemical and biological model systems
    J H Mitchell
    Division of Micronutrients and Lipid Metabolism, Rowett Research Institute, Bucksburn, AB21 9SB, UK
    Arch Biochem Biophys 360:142-8. 1998
    b>Phytoestrogens (PEs) are diphenolic compounds from plants which can bind to estrogen receptors and have estrogen and antiestrogen effects in man and animals...
  42. ncbi Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy?
    V Beck
    Department of Biotechnology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
    J Steroid Biochem Mol Biol 94:499-518. 2005
    ..Biochemical analysis shows that these representatives of phytoestrogens have multiple actions beside selective estrogen receptor modulator (SERM)-activity...
  43. ncbi Modulation of monoamine neurotransmitters in fighting fish Betta splendens exposed to waterborne phytoestrogens
    Ethan D Clotfelter
    Department of Biology, Amherst College, Amherst, MA 01002, USA
    Fish Physiol Biochem 36:933-43. 2010
    ..mature male fighting fish Betta splendens to environmentally relevant and pharmacological doses of three phytoestrogens that are potential endocrine disruptors in wild fish populations: genistein, equol, and β-sitosterol...
  44. ncbi Phytoestrogens enhance antioxidant enzymes after swimming exercise and modulate sex hormone plasma levels in female swimmers
    Antonia Mestre-Alfaro
    Laboratori de Ciencies de l Activitat Fisica, Department of Fundamental Biology and Health Sciences, Research group on Communitarian Nutrition and Oxidative Stress, IUNICS, Universitat de les Illes Balears, Ctra Valldemossa km 7 5, 07122 Palma de Mallorca, Illes Balears, Spain
    Eur J Appl Physiol 111:2281-94. 2011
    Our aim was to investigate the effects of diet supplementation with phytoestrogens on sex hormone levels, antioxidant adaptive responses and oxidative damage induced by exercise...
  45. ncbi Urinary concentrations of environmental contaminants and phytoestrogens in adults in Israel
    T Berman
    Public Health Services, Ministry of Health, Israel
    Environ Int 59:478-84. 2013
  46. ncbi Cardiovascular effects of the phytoestrogen genistein
    Domenica Altavilla
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, School of Medicine, University of Messina, Italy
    Curr Med Chem Cardiovasc Hematol Agents 2:179-86. 2004
    ..Of the several phytoestrogens, genistein in particular has been shown to be the most efficacious in animal models and experimental studies...
  47. ncbi Soy-derived phytoestrogens as preventive and acute neuroprotectors in experimental ischemic stroke: influence of rat strain
    M Castelló-Ruiz
    Centro de Investigacion, Hospital Universitario La Fe, Ave Campanar 21, 46009 Valencia, Spain Departamento de Fisiología, Universidad de Valencia, Ave Blasco Ibánez 15, 46010 Valencia, Spain
    Phytomedicine 18:513-5. 2011
  48. pmc Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice
    Carlos M Guerrero-Bosagna
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, WA, 99164 4231, USA
    BMC Physiol 8:17. 2008
    ..was to simulate an environmental exposure of an experimental population of mice to high amounts of nutritional phytoestrogens and to evaluate parameters of relevance for evolutionary change in the offspring...
  49. ncbi Phytoestrogen metabolites are much more active than phytoestrogens themselves in increasing prostaglandin F(2alpha) synthesis via prostaglanin F(2alpha) synthase-like 2 stimulation in bovine endometrium
    I Woclawek-Potocka
    Department of Reproductive Immunology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 747 Olsztyn, Poland
    Prostaglandins Other Lipid Mediat 78:202-17. 2005
    b>Phytoestrogens have recently been suggested to be the cause of infertility by stimulating luteolytic prostaglandin (PG) F(2alpha) secretion from endometrium in cattle...
  50. pmc Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report
    Huiyan Ma
    Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    BMC Complement Altern Med 11:109. 2011
    ..It remains unclear whether estrogenic botanical supplement (EBS) use influences breast cancer survivors' health-related outcomes...
  51. ncbi Comparison of the bone protective effects of an isoflavone-rich diet with dietary and subcutaneous administrations of genistein in ovariectomized rats
    T Hertrampf
    Institute for Cardiovascular Research and Sport Medicine, Department of Molecular and Cellular Sport Medicine, Deutsche Sporthochschule Koln, Germany
    Toxicol Lett 184:198-203. 2009
    ..Dietary intake of isoflavones by an IRD also did not result in a stimulation of UWW, yet IRD appeared to be more effective in bone protection than administration of pure GEN...
  52. pmc Prevention of bone resorption by intake of phytoestrogens in postmenopausal women: a meta-analysis
    Pooneh Salari Sharif
    Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, 16 Azar Ave, Tehran, Iran
    Age (Dordr) 33:421-31. 2011
    b>Phytoestrogens as selective estrogen receptor modulators like compounds may consider as a therapeutic option in osteoporosis...
  53. ncbi Joint effects of heterogeneous estrogenic chemicals in the E-screen--exploring the applicability of concentration addition
    Elisabete Silva
    Centre for Toxicology, School of Pharmacy, University of London, London WC1N1AX, UK
    Toxicol Sci 122:383-94. 2011
    ..compounds as diverse as steroidal hormones (endogenous and synthetic), pesticides, cosmetic additives, and phytoestrogens. CA was employed to predict mixture effects, which were then compared with experimental outcomes...
  54. ncbi Soy phytoestrogens: impact on postmenopausal bone loss and mechanisms of action
    Raewyn C Poulsen
    Institute of Food Nutrition and Human Health, Massey University, Palmerston North, New Zealand
    Nutr Rev 66:359-74. 2008
    Due to their ability to mimic the actions of mammalian estrogens, soy phytoestrogens have been proposed as potential therapeutic agents to aid in preventing postmenopausal bone loss...
  55. pmc A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice
    Christopher R Cederroth
    Department of Genetic Medicine and Development and National Center for Competence in Research Frontiers in Genetics, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Environ Health Perspect 115:1467-73. 2007
    ..b>Phytoestrogens are plant-derived compounds with estrogenic activities; they can bind to both estrogen receptors alpha and ..
  56. ncbi Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells
    Nobuyuki Kikuno
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Int J Cancer 123:552-60. 2008
    ..These findings strengthen the understanding of how genistein may be chemoprotective in prostate cancer...
  57. ncbi Risk of human ovarian cancer is related to dietary intake of selected nutrients, phytochemicals and food groups
    Susan E McCann
    Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY 14214, USA
    J Nutr 133:1937-42. 2003
    ..45, 95% CI, 0.22-0.92). These results support a protective effect on ovarian cancer of phytoestrogen intakes, and our results support the hypothesis that a plant-based diet may be important in reducing risks of hormone-related neoplasms...
  58. ncbi Effects of phytoestrogen genistein on genioglossus function and oestrogen receptors expression in ovariectomized rats
    Wen Li
    Department of Orthodontics, School of Stomatology, Tongji University, 399 YanChangZhong Road, Shanghai 200072, China
    Arch Oral Biol 54:1029-34. 2009
    ..This study was designed to investigate the effects of genistein on genioglossal muscle function and the expression of oestrogen receptors (ERs) in the ovariectomized rats...
  59. ncbi Treatment with phytoestrogen alpha-zearalanol might protect neurons of hippocampus in ovariectomized rats
    Yi Long Dong
    Institute of Basic Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 100005
    Endocrine 30:249-54. 2006
    ..This result suggests that alpha-ZAL may effectively abate neurons loss in the hippocampus while slightly promoting weight gain of the uterus...
  60. ncbi Effects of soy phytoestrogens genistein and daidzein on breast cancer growth
    M L de Lemos
    Provincial Systemic Therapy Program, British Columbia Cancer Agency, Vancouver, Canada
    Ann Pharmacother 35:1118-21. 2001
    To determine whether genistein and daidzein, the major phytoestrogens in soy, can stimulate breast cancer growth.
  61. ncbi Emerging evidence of the health benefits of S-equol, an estrogen receptor β agonist
    Richard L Jackson
    Ausio Pharmaceuticals, LLC, Cincinnati, Ohio, USA
    Nutr Rev 69:432-48. 2011
    ..These studies suggest that S-equol may provide therapeutic benefits for a number of medical needs...
  62. ncbi Pharmacokinetics and organ distribution of diarylheptanoid phytoestrogens from Curcuma comosa in rats
    Jian Su
    Center for Research and Development of Herbal Health Products, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
    J Nat Med 66:468-75. 2012
    ..This study provides the essential pharmacokinetic data for diarylheptanoid phytoestrogenic compounds of C. comosa extract which are required for clinical dose and dosage design...
  63. ncbi Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarin and 17β-oestradiol in ovariectomized rats
    Xu Lei Tang
    Department of Endocrinology, the First Hospital of Lanzhou University, China
    Basic Clin Pharmacol Toxicol 111:87-91. 2012
    ..Puerarin appeared to have a more powerful protective effect on DNA oxidative damage than E₂. The study indicates that postmenopausal women may benefit from phytoestrogen puerarin...
  64. ncbi Reproductive consequences of exposure to waterborne phytoestrogens in male fighting fish Betta splendens
    Louise M Stevenson
    Department of Biology, Amherst College, Amherst, MA 01002, USA
    Arch Environ Contam Toxicol 60:501-10. 2011
    b>Phytoestrogens are plant compounds that can act as endocrine disruptors in vertebrates...
  65. ncbi New concepts, experimental approaches, and dereplication strategies for the discovery of novel phytoestrogens from natural sources
    Thomas Michel
    Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece
    Planta Med 79:514-32. 2013
    b>Phytoestrogens constitute an attractive research topic due to their estrogenic profile and their biological involvement in woman's health...
  66. ncbi Genistein reduced the neural apoptosis in the brain of ovariectomised rats by modulating mitochondrial oxidative stress
    Yan Hong Huang
    Department of Obstetrics and Gynecology, Xi Jing Hospital, 4th Military Medical University, 17 Changle Westroad, Xi an 710032, People s Republic of China
    Br J Nutr 104:1297-303. 2010
    ..These results suggest that Gen confers protection against Ovx-induced neurodegeneration by attenuating oxidative stress, lipid peroxidation and the mitochondria-mediated apoptotic pathway in a region- and dose-dependent manner...
  67. pmc Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense)
    Cassia R Overk
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, M C 781, University of Illinois, 833 South Wood Street, Chicago, Illinois 60612, USA
    J Agric Food Chem 53:6246-53. 2005
    ..9 microg/mL, respectively, in the alkaline phosphatase induction assay. On the basis of these data, hops and red clover could be attractive for the development as herbal dietary supplements to alleviate menopause-associated symptoms...
  68. ncbi Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats
    Isabel Baeza
    Department of Physiology, Complutense University of Madrid, Spain
    Biogerontology 11:687-701. 2010
    ..Administration of growth hormone (GH), melatonin (MEL) and oestrogens (OE), as well as soybean phytoestrogens (PE) for 10 weeks, between 22 and 24 months of age, was able to decrease oxidative stress in the investigated ..
  69. ncbi Cardiovascular targets for estrogens and phytoestrogens: transcriptional regulation of nitric oxide synthase and antioxidant defense genes
    Richard C M Siow
    Cardiovascular Division, School of Medicine, King s College London, London, UK
    Free Radic Biol Med 42:909-25. 2007
    ..These intracellular signaling cascades may represent a fundamental mechanism by which dietary phytoestrogens maintain redox homeostasis in the vasculature in health and disease.
  70. ncbi Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial
    Jian Wu
    Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan
    Menopause 14:866-74. 2007
    ..This study aimed to investigate whether the effects of soy isoflavones on bone and fat mass are related to an individual's equol status...
  71. ncbi Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms: a randomized, double-blind trial
    Silvina Levis
    Geriatric Research, Education, and Clinical Center, Miami Veterans Affairs Healthcare System, USA
    Arch Intern Med 171:1363-9. 2011
    ..Our goal was to determine the efficacy of soy isoflavone tablets in preventing bone loss and menopausal symptoms...
  72. ncbi Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells
    M Maggiolini
    Department of Pharmaco-Biology, University of Calabria, Rende-Cosenza, Italy
    Mol Pharmacol 60:595-602. 2001
    b>Phytoestrogens are a chemically diverse group of compounds made by plants that can have estrogenic effects in animals. Both tumorigenic and antitumorigenic effects have been reported...
  73. ncbi Long-term effect of phytoestrogens from Curcuma comosa Roxb. on vascular relaxation in ovariectomized rats
    Suttira Intapad
    Department of Physiology, Mahidol University, Bangkok, Thailand 10400
    J Agric Food Chem 60:758-64. 2012
    b>Phytoestrogens have been implicated as promising therapeutic agents to treat the vascular impairment seen in menopausal women. The present study investigated the long-term effects of phytoestrogens from Curcuma comosa Roxb...
  74. ncbi Lack of sufficient information on the specificity and selectivity of commercial phytoestrogens preparations for therapeutic purposes
    Guy Leclercq
    Laboratoire J C Heuson de Cancérologie Mammaire, Universite Libre De Bruxelles U L B, Institut Jules Bordet, 1000 Brussels, Belgium
    Maturitas 68:56-64. 2011
    b>Phytoestrogens (PEs) are polyphenols of plant origin among which flavones, flavanones, isoflavones, coumarins, chalcones, lignans and stilbenes are the best representatives...
  75. ncbi Phytoestrogen-mediated inhibition of proliferation of the human T47D breast cancer cells depends on the ERalpha/ERbeta ratio
    A M Sotoca
    Toxicology Section, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands
    J Steroid Biochem Mol Biol 112:171-8. 2008
    ..of the intracellular ratio of the two estrogen receptors ERalpha and ERbeta for the ultimate potential of the phytoestrogens genistein and quercetin to stimulate or inhibit cancer cell proliferation...
  76. ncbi Phytoestrogens for menopausal symptoms: a review
    John A Eden
    School of Women and Children s Health, University of NSW, Randwick, NSW 2031, Australia
    Maturitas 72:157-9. 2012
    ..To review the evidence that isoflavones are effective treatments for menopausal symptoms and to present the safety data...
  77. ncbi The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial
    Charlotte Atkinson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, United Kingdom
    Am J Clin Nutr 79:326-33. 2004
    ..Isoflavone phytoestrogen therapy has been proposed as a natural alternative to hormone replacement therapy (HRT). HRT has a beneficial effect on bone, but few trials in humans have investigated the effects of isoflavones on bone...
  78. ncbi Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-kappaB signaling in HER2-overexpressing breast cancer cells
    Hye Sook Seo
    Laboratory of Clinical Biology and Pharmacogenomics and Center for Clinical Research and Genomics, Institute of Oriental Medicine, Kyung Hee University, 1 Hoegi dong, Dongdaemun Gu, Seoul 130 701, Republic of Korea
    Anticancer Res 31:3301-13. 2011
    b>Phytoestrogens are known to prevent tumor induction. But their molecular mechanisms of action are largely unknown...
  79. pmc Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology
    C M Weaver
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907 2059, USA
    J Clin Endocrinol Metab 94:3798-805. 2009
    ..Isoflavones have been reported to protect bone from estrogen deficiency, but their modest effects on bone resorption have been difficult to measure with traditional analytical methods...
  80. ncbi Phytoestrogens regulate vitamin D metabolism in the mouse colon: relevance for colon tumor prevention and therapy
    Enikö Kállay
    Department of Pathophysiology, University of Vienna Medical School, Vienna, Austria
    J Nutr 132:3490S-3493S. 2002
    Soybean products are highly represented in the traditional Asian diet. Major components of soy proteins are phytoestrogens, such as isoflavones...
  81. ncbi Phytoestrogens as cardioprotective agents
    Denise Park
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Cardiol Rev 13:13-7. 2005
    Epidemiologic studies have shown that women with a higher dietary intake of phytoestrogens, plant-derived compounds with partial estrogen agonist properties, have a lower incidence of cardiovascular disease and breast and uterine cancer ..
  82. pmc Intermolecular interactions identify ligand-selective activity of estrogen receptor alpha/beta dimers
    Emily Powell
    McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 105:19012-7. 2008
    ..Thus, ER homodimer and heterodimer BRET assays are applicable to drug screening for dimer-selective selective ER modulators. Furthermore, this strategy can be used to study other nuclear receptor dimers...
  83. ncbi Dietary phytoestrogens have anti-inflammatory activity in a guinea pig model of asthma
    J F Regal
    Department of Pharmacology, University of Minnesota, Duluth, Minnesota 55812, USA
    Proc Soc Exp Biol Med 223:372-8. 2000
    b>Phytoestrogens are a normal constituent of soy protein and have been shown to have anti-inflammatory activity in various in vitro and in vivo models...
  84. ncbi Detection of phytoestrogens in samples of second trimester human amniotic fluid
    Warren G Foster
    Center for Women s Health, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Toxicol Lett 129:199-205. 2002
    ..present study was performed to develop the necessary analytical methods and test the hypothesis that dietary phytoestrogens can be quantified in second trimester human amniotic fluid...
  85. ncbi Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells
    Liat Abovich Gilad
    Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    J Endocrinol 191:387-98. 2006
    ..In contrast, the same assays demonstrated that the Sp-1, but not AP-1, site is induced by the phytoestrogens. Similar to E2, genistein, glycitein and the isoflavonoid metabolite equol induced higher concentrations of ..
  86. ncbi Reference profile correlation reveals estrogen-like trancriptional activity of Curcumin
    Beatrice E Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Ludwig Maximilians University, Munich, Germany
    Cell Physiol Biochem 26:471-82. 2010
    Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes...
  87. ncbi Phytoestrogens and mycotoxins in Iowa streams: an examination of underinvestigated compounds in agricultural basins
    Dana W Kolpin
    U S Geological Survey, 400 S Clinton St, Suite 269, Iowa City, IA 52244, USA
    J Environ Qual 39:2089-99. 2010
    This study provides the first broad-scale investigation on the spatial and temporal occurrence of phytoestrogens and mycotoxins in streams in the United States...
  88. pmc Estrogenic effects of herbal medicines from Costa Rica used for the management of menopausal symptoms
    Brian J Doyle
    Departments of Medicinal Chemistry and Pharmacognosy and Pharmacy Practice, College of Pharmacy, Pan American Health Organization World Health Organization Collaborating Centre for Traditional Medicine, Chicago, IL 60612, USA
    Menopause 16:748-55. 2009
    ..To this end, we have been investigating natural herbal medicines used by Costa Rican women to manage menopausal symptoms...
  89. ncbi Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study
    Vittorio Unfer
    AGUNCO, Obstetrics and Gynecology Centre, Rome, Italy
    Fertil Steril 82:145-8, quiz 265. 2004
    To determine the effects of 5 years of treatment with soy phytoestrogens on histological characteristics of endometrium in postmenopausal women.
  90. ncbi Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogens
    Jason D Gardner
    Department of Cell and Developmental Bioloogy and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Am J Physiol Heart Circ Physiol 294:H198-204. 2008
    ..We hypothesized that both phytoestrogens and ovarian hormones, particularly estrogen, are necessary for this dietary-induced cardioprotection...
  91. ncbi The relevance of estrogen receptor-beta expression to the antiproliferative effects observed with histone deacetylase inhibitors and phytoestrogens in prostate cancer treatment
    Mark Stettner
    Department of Urology, Georg August University, 37099 Gottingen, Germany
    Mol Cancer Ther 6:2626-33. 2007
    In the prostate, estrogen receptor beta (ERbeta), the preferred receptor for phytoestrogens, has features of a tumor suppressor...
  92. ncbi Does an apple a day keep the doctor away because a phytoestrogen a day keeps the virus at bay? A review of the anti-viral properties of phytoestrogens
    J H J Martin
    Research Institute of Healthcare Science, University of Wolverhampton, Wulfruna Street, Wolverhampton, WV1 1SB, United Kingdom
    Phytochemistry 68:266-74. 2007
    From dengue to herpes and influenza to AIDS, the phytoestrogens that are present in many fruits and vegetables have been shown to exert anti-viral properties...
  93. pmc Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms
    Nica M Borradaile
    Department of Biochemistry, University of Western Ontario, London, ON, Canada N6A 5C1
    Biochem J 366:531-9. 2002
    Diets containing the soya-derived phytoestrogens, genistein and daidzein, decrease plasma cholesterol in humans and experimental animals. The mechanisms responsible for the hypocholesterolaemic effects of these isoflavones are unknown...
  94. ncbi Phytoestrogens directly inhibit TNF-α-induced bone resorption in RAW264.7 cells by suppressing c-fos-induced NFATc1 expression
    Sahar Karieb
    School of Biomedical and Biological Sciences, University of Plymouth, Plymouth, UK
    J Cell Biochem 112:476-87. 2011
    ..osteoclastogenesis is central to post-menopausal and inflammatory bone loss, however, the effect of phytoestrogens on TNF-α-induced bone resorption has not been studied...
  95. pmc The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study
    T Y Tai
    Division of Geriatric Research, Institute of Population Health Sciences, National Health Research Institutes, Taipei, Taiwan
    Osteoporos Int 23:1571-80. 2012
  96. pmc Soy phytoestrogens are neuroprotective against stroke-like injury in vitro
    D A Schreihofer
    Department of Physiology, CA3145, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 3000, USA
    Neuroscience 158:602-9. 2009
    ..This protective effect is hypothesized to be mediated by phytoestrogens contained in soy, because some of these compounds have neuroprotective effects in in vitro models of cell ..
  97. ncbi Alternative and complementary therapies for the menopause
    Joan Pitkin
    Northwick Park and St Marks Hospital NPMH, NW London Hospitals NHS Trust, Watford Road, Harrow, HA1 3UJ, UK
    Menopause Int 18:20-7. 2012
    ..Of the herbal medicinal products, the largest evidence base rests with phytoestrogens. A Cochrane Database review looking at all types of phytoestrogens, e.g...
  98. ncbi Phytoestrogens induce differential estrogen receptor beta-mediated responses in transfected MG-63 cells
    Xiaolu Tang
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
    Endocrine 34:29-35. 2008
    b>Phytoestrogens may function as partial agonists or antagonists of estrogen in many tissues including bone...
  99. ncbi Daucane phytoestrogens: a structure-activity study
    Giovanni Appendino
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale, Viale Ferrucci 33, 28100 Novara, Italy
    J Nat Prod 65:1612-5. 2002
    ..Homologation and vinylation were both detrimental for activity, as were methylation of the p-hydroxyl substituent and the introduction of oxygen functions on the adjacent carbons...
  100. ncbi A protective effect of Curcuma comosa Roxb. on bone loss in estrogen deficient mice
    Jittima Weerachayaphorn
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    J Ethnopharmacol 137:956-62. 2011
    ..Curcuma comosa Roxb. or Wan chak motluk is an indigenous medicinal herb and has traditionally been used among postmenopausal women for relief of unpleasant menopausal symptoms...
  101. ncbi Dietary phytoestrogens and the risk of ovarian cancer in the women's lifestyle and health cohort study
    Maria Hedelin
    Department of Genetic Research, Folkhalsan Research Center, Biomedicum Helsinki, Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 20:308-17. 2011
    Dietary intake of phytoestrogens has been inversely associated to hormone-dependent cancers, such as prostate and breast cancers. Few studies have investigated the association between ovarian cancer and intake of phytoestrogens...

Research Grants65

  1. A Molecular Basis for Phytoestrogen Chemoprevention
    Andrew Mesecar; Fiscal Year: 2002
    ..Two of the major sources of dietary phytoestrogens are soy and red clover, and to a lesser extent licorice and hops...
  2. Xenoestrogen regulation of Leydig cells
    ..Approximately 15% of infants fed soy-based formulas in the United States each year are exposed to the phytoestrogens genistein and daidzen, which are the predominant isoflavones in soybeans...
  3. Modifiers of hepcidin expression as new therapies for iron overload
    PAULA GOODMAN FRAENKEL; Fiscal Year: 2013
    ..These studies will lead to the identification of molecules and pathways that may be adapted to generate treatments for patients with thalassemia or hereditary hemochromatosis. ..
  4. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
    ..Recent data demonstrate that high selenium (Se) intake or status and high intake of phytoestrogens (isoflavones) each provide a protective effect against prostate cancer, and that their combined use may ..
  5. Estrogen-T cell Interactions
    Prakash S Nagarkatti; Fiscal Year: 2013
    ..Furthermore, a number of xenoestrogens which include environmental estrogens and phytoestrogens have been identified which bind estrogen receptors (ERs) and mediate activity similar to physiological ..
  6. Defining Estrogenic Regulation of Hematopoietic Stem Cell Formation and Function
    Trista E North; Fiscal Year: 2013
    ..In Specific Aim 2, they will analyze the specific effects of xenoestrogens (bisphenol A), dietary phytoestrogens (genistein), and mycoestrogens (zearalenone) during HSC formation;they will demonstrate that these effects are ..
  7. Bacterial and Chemical Carcinogens in Gastric Oncogenesis
    D Scott Merrell; Fiscal Year: 2012
    ..epithelial cells may potentiate the effects of dietary carcinogens and be counteracted by protective dietary phytoestrogens;(2) an imbalance between the functions of effector and regulatory T cells may promote carcinogenesis;and (3) ..
  8. Therapeutic Efficacy of Flaxseed in the Treatment of Ovarian Cancer
    Dale B Hales; Fiscal Year: 2013
  9. A study evaluating the effect of flaxseed on biomarkers of breast cancer risk
    Swati Kulkarni; Fiscal Year: 2010
    ..This study will determine if flaxseed can reduce the number of growing cells in the breast of young women who are at increased risk of developing breast cancer. ..
  10. Training in Molecular and Mechanistic Toxicology
    Edson X Albuquerque; Fiscal Year: 2012
    ..common interest in basic, clinical and ecological research applied to such environmental toxicants as metals, phytoestrogens, dioxins, and insecticides, and interests span from basic to clinical and environmental research...
    Susan E Hankinson; Fiscal Year: 2011
    ..Further, confirmation of protective associations for vitamin D or enterolactone, factors amenable to change through lifestyle choices, would have important public health implications. ..
  12. Dietary and serum phytoestrogens and women's health conditions in midlife
    Gail A Greendale; Fiscal Year: 2012
    ..estrogen-associated diseases, such a breast cancer and hip fracture, are lower in regions where diets high in phytoestrogens are consumed...
  13. Identification of novel phytoprogestins from hops and red clover
    Joanna E Burdette; Fiscal Year: 2011
    ..Two common supplements, hops and red clover, contain phytoestrogens that bind and activate estrogen receptors...
  14. Bacterial Biosensors for Endocrine Disrupting Compounds
    David W Wood; Fiscal Year: 2009
    ..This system has been shown to be capable of detecting a wide variety of estrogenic compounds, including phytoestrogens, xenoestrogens, and estrogenic steroids, and it can reliably differentiate agonistic from antagonistic ..
  15. Phytoestrogen and Endogenous Estrogen Exposure and Risk of Stroke
    Xianglan Zhang; Fiscal Year: 2013
    ..Since phytoestrogens, plant-derived estrogens, are known to possess estrogenic effects similar to SERMs and have been marketed as ..
  16. Effects of Estradiol &Phytoestrogens on Stress Responsivity
    Pauline M Maki; Fiscal Year: 2013
    ..Compounds that preferentially target ER-beta, including plant-derived estrogens (phytoestrogens), lower both anxiety behaviors and responsivity to discrete stressors, including social stress, in laboratory ..
  17. Phytoestrogens and Cancer
    Wesley Gray; Fiscal Year: 2009
    Dietary phytoestrogens (PEs) have been given considerable attention due to their protective role in certain hormone-dependent cancers...
  18. Reversing the Effects of Developmental Reprogramming
    Cheryl L Walker; Fiscal Year: 2012
  19. Phytoestrogens, insulin resistance and endothelial function
    NINA STACHENFELD; Fiscal Year: 2012
    ..vasomotor symptoms and decreasing the risk of cardiovascular disease, many women choose over the counter phytoestrogens in favor of estrogens prescribed by their physicians...
  20. Effects of herbs on transcription and cell proliferation
    Dale Leitman; Fiscal Year: 2003
    ..High intake of plant estrogens (phytoestrogens) is associated with a low incidence of breast cancer, A key question is: Why do estrogens increase the risk of ..
  21. Alternative mechanisms of selective estrogen receptor modulation in cancer preven
    Chin Yo Lin; Fiscal Year: 2010
    ..ER is also a molecular target of phytoestrogens, a group of plant-derived phenolic compounds which are structurally similar to estrogen and SERMs...
  22. Estrogen Receptor-beta phytoSERMs for Management of Menopause and Memory Decline
    Lon S Schneider; Fiscal Year: 2012
    ..A formulation composed of rationally-selected ER2-selective phytoestrogens (phytoSERMs) was developed that provides a greater effect than the various nutraceuticals that are mixed with ..
  23. Flaxseed effects on hormones and lignans: role of race, genes, and gut microbiome
    Susan E McCann; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lignans are phytoestrogens which have been studied fairly extensively as dietary factors in breast cancer etiology due to structural and functional similarities to endogenous estrogens...
  24. The effects of endogenous and dietary estrogens on colonic stem cells
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2013
    ..Although there are concerns related to estrogen therapy, dietary phytoestrogens may provide a suitable alternative...
  25. Disposition of Environmental Chemicals During Pregnancy
    Lauren M Aleksunes; Fiscal Year: 2013
    ..A detailed understanding of the regulation of placental BCRP will allow us to predict which patients are at greater risk for adverse effects of EDCs. ..
  26. Testing Direct Effects of Soy Daidzein on Fragile X Phenotypes
    CARA JEAN WESTMARK; Fiscal Year: 2013
    ..The long-term goal of this project is provide solid pre-clinical data in Fmr1KO mice that support the restriction of soy-based infant formulas for babies with FXS and other neurodevelopmental disorders. ..
  27. RRISK Prospective Cohort
    Jeanette S Brown; Fiscal Year: 2011
    ..between pre-diabetes and Ul;do adipocytokines explain the relationship between obesity and incontinence;do phytoestrogens increase the risk of Ul;are estrogen receptor gene polymorphisms risk factors for Ul;and what are risk factors ..
  28. Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosis
    Susan McCann; Fiscal Year: 2009
    ..Because the phytoestrogens in flaxseed can influence many of the same biologic pathways affected by hormonal agents, diet-drug ..
    Stephen Schwartz; Fiscal Year: 1999
    b>Phytoestrogens (such as isoflavones and lignans) and organochlorine compounds (such as pesticides and polychlorinated biphenyls) are two broad classes of putative endocnne disruptors -- chemicals that may have the capability to alter a ..
  30. iGOT neuroprotection
    CAMERON LUCIAN RINK; Fiscal Year: 2013
    ..The focus of the proposal is to address a central hypothesis which is conceptually innovative in highlighting the significance of iGOT on [Glu]o metabolism during ischemic stroke. ..
  31. Variations in plasma phytoestrogen levels in Europe
    Petra Peeters; Fiscal Year: 2004
    b>Phytoestrogens, widespread plant compounds, have been proposed as protective agents against hormone dependent cancers in humans, but results from human studies are inconclusive...
  32. Absorption and Metabolism of Isoflavones
    Ming Hu; Fiscal Year: 2005
    Genistein, an isoflavone, is a member of the dietary phytoestrogens that are believed to have chemopreventive effect and is currently undergoing clinical trial for prostate cancer prevention...
  33. Development Modulation of Mouse Uterine Tumorigenesis
    Shuk Mei Ho; Fiscal Year: 2006
    ..supplements and pharmaceutical agents has dramatically increased due to the presumed beneficial effects of phytoestrogens in preventing cardiovascular diseases and cancer...
  34. Timing of Dietary Exposures and Breast Cancer Risk
    Leena Hilakivi Clarke; Fiscal Year: 2001
    ..e., fatty acids, phytoestrogens, heavy metals, calcium, and vitamins D and A...
  35. Diet and Risk of Ovarian Cancer
    Ellen Chang; Fiscal Year: 2005
    ..Our specific aims are to evaluate the relationship between ovarian cancer risk and (a) phytoestrogens and isothiocyanates, (b) eggs, dietary fats and dairy products, (c) alcohol, and (d) dietary patterns...
    James Goodrich; Fiscal Year: 1999
    ..Plant estrogens, also termed isoflavones or phytoestrogens found in legumes such as soybeans and red clover are a natural alternative which may have greater acceptance ..
  37. Interactions Between Dietary Soy Components & Tamoxifen
    Jin Rong Zhou; Fiscal Year: 2003
    ..On the other hand, soy isoflavones are weak phytoestrogens and may interfere with TAM in competing with the binding sites of estrogen-receptors and modulate estrogen-..
    Andreas Constantinou; Fiscal Year: 2002
    ..It is presently uncertain if these women are benefitted or harmed by consuming soy products, or by taking phytoestrogens as supplements...
  39. Phytoestrogens as an alternative treatment for MS
    Larry Sherman; Fiscal Year: 2006
    ..One class of non-steroidal estrogens that may have the capacity to suppress MS is phytoestrogens. Phytoestrogens are plant-derived compounds that are structurally similar to steroidal estrogens...
  40. Soy Isoflavone Distribution in Biological Fluids as Markers of Prostate Exposure
    MINDY KURZER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. Mechanism(s)of antitumor action of tamoxifen and soy
    Andreas Constantinou; Fiscal Year: 2003
    ..The soy phytoestrogens genistein and daidzein selectively bind to ERbeta...
    JANICE BAHR; Fiscal Year: 2002
    ..This treatment is, however, not acceptable to all women. An alternative approach is intake of foods rich in phytoestrogens - natural plant estrogens such as soybeans...
    ELAINE LIPSCOMB; Fiscal Year: 1999
    ..Accordingly, compliance with ERT regimes is low. There is increasing interest in the use of phytoestrogens (plant compounds with structural or functional similarity to estradiol) as a possible alternative to ERT...
  44. Cell Growth Inhibiton and Estrogen Action
    Barry Markaverich; Fiscal Year: 2004
    ..very specific genomic pathways for regulation by MeHPLA and related-compounds including bioflavonoids and phytoestrogens. These compounds bind to type II sites (histone H4) with high affinity and have classically been defined as ..
  45. Vitamin D, alcohol, and risk of lymphomas in a prospective cohort of women
    ELLEN TING YEE CHANG; Fiscal Year: 2010
    ..whether exposure to vitamin D from diet or sunlight;indices of dietary antioxidant intake;consumption of phytoestrogens or isothiocyanates;or consumption of alcohol at various ages is associated with reduced risk of lymphoid ..
  46. Dietary lignan effects on hormone, growth, and signaling factors in breast tumors
    Susan McCann; Fiscal Year: 2009
    ..The results of this study may provide us with important information that can be useful in understanding the effect of diet on development of different breast cancer sub-types. ..
  47. CVD Mechanisms Associated with Phytoestrogens Use
    Donna Kritz Silverstein; Fiscal Year: 2003
    ..However, a large proportion of postmenopausal women are not compliant with therapeutic regimens. Phytoestrogens are naturally occurring compounds found in plants and soy products that have SERM-like effects...
  48. Interactions between SERMs, soy and black cohosh
    Heather Shaw; Fiscal Year: 2007
    ..Each of these substances has also been shown to contain phytoestrogens, plant derived substances, which interact functionally with ER...
    Bahram Arjmandi; Fiscal Year: 1999
    ..Recent reports have indicated that several classes of estrogen-like compound phytoestrogens; pharmacologically and structurally similar to tamoxifen, an estrogen agonist/antagonist) have bone protective ..
  50. Selenium, Isoflavones, Androgen Metabolism and Prostate Cancer Risk Reduction
    MERRILL CHRISTENSEN; Fiscal Year: 2009 is to elucidate the biochemical and molecular mechanisms by which the interaction of selenium (Se) and phytoestrogens reduces the risk for prostate cancer...
  51. Phytoestrogen and Antioxidant Regulation of Prostate Cancer
    Dennis Lubahn; Fiscal Year: 2009
    ..Our overall hypothesis is that differential regulation of ERalpha and ERP by plant phytoestrogens, acting essentially as natural SERMs, will be effective in human prostate cancer prevention and treatment...
    Judith Balk; Fiscal Year: 1999
    The principal investigator, responding to topic #5, "alternatives to estrogen therapy", is a new investigator. Phytoestrogens are natural estrogens found in plants...
    LEE JANE LU; Fiscal Year: 1999
    DESCRIPTION: Previous studies show that consumption of soy milk containing significant quantities of the phytoestrogens, daidzein and genistein, by females for one month, effectively reduces levels of endogenous ovarian hormones and ..
    Bernard Weiss; Fiscal Year: 2000
    ..such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the polychlorinated biphenyls, and some isoflavonoid phytoestrogens. Their potential health hazards, until recently, were dominated by concerns over carcinogenicity following ..
  55. Urinary Phytoestrogen Excretion and Breast Cancer Risk
    Wei Zheng; Fiscal Year: 2001
    b>Phytoestrogens, primarily isoflavones and lignans, have been implicated strongly in animal and in vitro experiments as promising compounds against cancer, particularly breast and other hormone-related cancers...
  56. Estrogen Receptor-Selective Herbs for Menopause Symptoms
    Dale Leitman; Fiscal Year: 2006
    ..Many women seek alternatives to HRT, particularly estrogens derived from plants, known as phytoestrogens. Interest in phytoestrogens has been fueled by observational studies showing a lower incidence of menopausal ..
    JAY KAPLAN; Fiscal Year: 2004
    ..Potential benefits of soy phytoestrogens (SPEs) for breast and uterus of females and of prostate of males constitute a secondary focus...
  58. Estrogens, Paracrine Factors, and Endometrial Cancer
    David Kaufman; Fiscal Year: 2006
    ..Despite this, Selective Estrogen Receptor Modulators (SERMs) and protective, anti-proliferative phytoestrogens that influence this process have only been characterized in malignant epithelial cell lines where this ..
  59. Dietary Supplements and CAM Use in Breast Cancer Survivors
    Juliann Pierson; Fiscal Year: 2009
    ..This information can be utilized by health care providers in order to understand patient behaviors and address potential risks and benefits associated with the use of CAM in addition to standard treatment. ..
    Katherine Newton; Fiscal Year: 2004
    ..randomized controlled trial is to evaluate the efficacy and safety of three alternative approaches utilizing phytoestrogens to treat vasomotor symptoms in peri- and postmenopausal women...
    Bruce Blumberg; Fiscal Year: 2001
    ..However, other compounds such as phytoestrogens, fatty amides such as anandamide and retinoid X receptor (RXR) agonists have also demonstrated effectiveness ..
  62. Effects of dietary phytoestrogens on the aging brain
    Cynthia Corbitt; Fiscal Year: 2006
    The overall objective of this proposal is to investigate the hypothesis that dietary levels of phytoestrogens are neuroprotective to the aging central nervous system (CNS)...
  63. Isoflavones, equol producing status, and breast density in US Chinese women
    Carolyn Fang; Fiscal Year: 2009
    Isoflavones, phytoestrogens found primarily in soy foods, are thought to protect against breast cancer, but epidemiologic evidence for such an effect is inconsistent...
    James Williams; Fiscal Year: 2004
    ..Soy phytoestrogens (SPEs) may be an effective alternative approach to progestogen therapy...
  65. Endocrine Modulation by Hormones and Non-Steroidals
    Stuart Adler; Fiscal Year: 2003
    ..that also have the potential to act as mimics of the natural female steroid hormone, estradiol, and these "phytoestrogens" have received attention as being beneficial to human health...