cd4 positive t lymphocytes

Summary

Summary: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Top Publications

  1. Genesca M, Miller C. Use of nonhuman primate models to develop mucosal AIDS vaccines. Curr HIV/AIDS Rep. 2010;7:19-27 pubmed publisher
    ..Nonhuman primate models offer the best system for preclinical evaluation of these approaches...
  2. Tapmeier T, Fearn A, Brown K, Chowdhury P, Sacks S, Sheerin N, et al. Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction. Kidney Int. 2010;78:351-62 pubmed publisher
    ..These cells could be a potential target of therapeutic intervention to prevent excessive fibrosis and loss of function due to renal injury. ..
  3. Slingluff C, Petroni G, Smolkin M, Chianese Bullock K, Smith K, Murphy C, et al. Immunogenicity for CD8+ and CD4+ T cells of 2 formulations of an incomplete freund's adjuvant for multipeptide melanoma vaccines. J Immunother. 2010;33:630-8 pubmed publisher
    ..Despite the necessarily retrospective nature of the analysis and limitations of multiple comparisons, our summary data support the use of IFA-VG as an adjuvant with multipeptide vaccines in melanoma patients. ..
  4. Cannons J, Wu J, Gomez Rodriguez J, Zhang J, Dong B, Liu Y, et al. Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation. J Immunol. 2010;185:2819-27 pubmed publisher
  5. Wesley J, Sather B, Perdue N, Ziegler S, Campbell D. Cellular requirements for diabetes induction in DO11.10xRIPmOVA mice. J Immunol. 2010;185:4760-8 pubmed publisher
    ..These results help define the events leading to diabetes in DORmO mice and provide new insights into the cellular interactions required for disease development in an Ag-specific model of T1D...
  6. Estrela Lima A, Araújo M, Costa Neto J, Teixeira Carvalho A, Barrouin Melo S, Cardoso S, et al. Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates. BMC Cancer. 2010;10:256 pubmed publisher
    ..The goal of this study was to characterize the clinical-pathological status and the immunophenotyping profile of tumor infiltrating lymphocytes and their association with the animal survival rates in canine mammary carcinomas...
  7. Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm M, Villinger F, et al. Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses. J Immunol. 2010;185:1650-9 pubmed publisher
  8. Campbell J, Clark R, Watanabe R, Kupper T. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood. 2010;116:767-71 pubmed publisher
    ..Our results suggest that SS is a malignancy of central memory T cells and MF is a malignancy of skin resident effector memory T cells...
  9. Sanhadji K, Tardy J, Touraine J. HIV-1 infection: functional competition between gp41 and interleukin-2. C R Biol. 2010;333:608-12 pubmed publisher
    ..These data suggest that the gp41 of HIV-1 can use the IL-2 receptor during the process of HIV-1 infection and that there is some functional mimesis between gp41 and IL-2. ..
  10. Gnanadurai C, Pandrea I, Parrish N, Kraus M, Learn G, Salazar M, et al. Genetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green monkeys. J Virol. 2010;84:12245-54 pubmed publisher
    ..These results thus extend the T/F virus concept to nonpathogenic SIV infections and provide an important new tool to define viral determinants of disease nonprogression...

Detail Information

Publications163 found, 100 shown here

  1. Genesca M, Miller C. Use of nonhuman primate models to develop mucosal AIDS vaccines. Curr HIV/AIDS Rep. 2010;7:19-27 pubmed publisher
    ..Nonhuman primate models offer the best system for preclinical evaluation of these approaches...
  2. Tapmeier T, Fearn A, Brown K, Chowdhury P, Sacks S, Sheerin N, et al. Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction. Kidney Int. 2010;78:351-62 pubmed publisher
    ..These cells could be a potential target of therapeutic intervention to prevent excessive fibrosis and loss of function due to renal injury. ..
  3. Slingluff C, Petroni G, Smolkin M, Chianese Bullock K, Smith K, Murphy C, et al. Immunogenicity for CD8+ and CD4+ T cells of 2 formulations of an incomplete freund's adjuvant for multipeptide melanoma vaccines. J Immunother. 2010;33:630-8 pubmed publisher
    ..Despite the necessarily retrospective nature of the analysis and limitations of multiple comparisons, our summary data support the use of IFA-VG as an adjuvant with multipeptide vaccines in melanoma patients. ..
  4. Cannons J, Wu J, Gomez Rodriguez J, Zhang J, Dong B, Liu Y, et al. Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation. J Immunol. 2010;185:2819-27 pubmed publisher
  5. Wesley J, Sather B, Perdue N, Ziegler S, Campbell D. Cellular requirements for diabetes induction in DO11.10xRIPmOVA mice. J Immunol. 2010;185:4760-8 pubmed publisher
    ..These results help define the events leading to diabetes in DORmO mice and provide new insights into the cellular interactions required for disease development in an Ag-specific model of T1D...
  6. Estrela Lima A, Araújo M, Costa Neto J, Teixeira Carvalho A, Barrouin Melo S, Cardoso S, et al. Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates. BMC Cancer. 2010;10:256 pubmed publisher
    ..The goal of this study was to characterize the clinical-pathological status and the immunophenotyping profile of tumor infiltrating lymphocytes and their association with the animal survival rates in canine mammary carcinomas...
  7. Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm M, Villinger F, et al. Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses. J Immunol. 2010;185:1650-9 pubmed publisher
  8. Campbell J, Clark R, Watanabe R, Kupper T. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood. 2010;116:767-71 pubmed publisher
    ..Our results suggest that SS is a malignancy of central memory T cells and MF is a malignancy of skin resident effector memory T cells...
  9. Sanhadji K, Tardy J, Touraine J. HIV-1 infection: functional competition between gp41 and interleukin-2. C R Biol. 2010;333:608-12 pubmed publisher
    ..These data suggest that the gp41 of HIV-1 can use the IL-2 receptor during the process of HIV-1 infection and that there is some functional mimesis between gp41 and IL-2. ..
  10. Gnanadurai C, Pandrea I, Parrish N, Kraus M, Learn G, Salazar M, et al. Genetic identity and biological phenotype of a transmitted/founder virus representative of nonpathogenic simian immunodeficiency virus infection in African green monkeys. J Virol. 2010;84:12245-54 pubmed publisher
    ..These results thus extend the T/F virus concept to nonpathogenic SIV infections and provide an important new tool to define viral determinants of disease nonprogression...
  11. Katz J, Ondr J, Opoka R, Garcia Z, Janssen E. Cutting edge: merocytic dendritic cells break T cell tolerance to beta cell antigens in nonobese diabetic mouse diabetes. J Immunol. 2010;185:1999-2003 pubmed publisher
    ..Thus, the mcDC subset appears to represent the long-sought APC responsible for breaking peripheral tolerance to beta cell Ags in vivo. ..
  12. Kimpel J, Braun S, Qiu G, Wong F, Conolle M, Schmitz J, et al. Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection. PLoS ONE. 2010;5:e12357 pubmed publisher
  13. McAleer J, Vella A. Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide. Trends Immunol. 2010;31:429-35 pubmed publisher
    ..How this knowledge might be exploited to target specific features of T cell immunity by vaccine adjuvants is also considered. ..
  14. Day D, Luquette L, Park P, Kharchenko P. Estimating enrichment of repetitive elements from high-throughput sequence data. Genome Biol. 2010;11:R69 pubmed publisher
  15. Li Y, Messina C, Bendaoud M, Fine D, Schreiner H, Tsiagbe V. Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Mol Oral Microbiol. 2010;25:275-92 pubmed publisher
    ..The study provides a rationale for a link between periodontal disease and other systemic diseases. ..
  16. Yin W, He Q, Hu Z, Chen Z, Qifeng M, Zhichun S, et al. A novel therapeutic vaccine of GM-CSF/TNFalpha surface-modified RM-1 cells against the orthotopic prostatic cancer. Vaccine. 2010;28:4937-44 pubmed
  17. Gnerlich J, Mitchem J, Weir J, Sankpal N, Kashiwagi H, Belt B, et al. Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer. J Immunol. 2010;185:4063-71 pubmed publisher
    ..The delayed tumor growth and improved survival suggests that induction of Th17 in the tumor microenvironment produces an antitumor effect. ..
  18. Wernimont S, Simonson W, Greer P, Seroogy C, Huttenlocher A. Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. PLoS ONE. 2010;5:e10513 pubmed publisher
    ..These results challenge previous reports that implicate a central role for calpains in the regulation of T cell LFA-1 function. ..
  19. Streeck H, Nixon D. T cell immunity in acute HIV-1 infection. J Infect Dis. 2010;202 Suppl 2:S302-8 pubmed publisher
    ..Thus, HIV-1-specific CD8(+) T cell responses in acute HIV-1 infection appear uniquely able to efficiently suppress viral replication, whereas CD8(+) T cell responses generated in the chronic phase of infection appear often impaired. ..
  20. Pourgheysari B, Bruton R, Parry H, Billingham L, Fegan C, Murray J, et al. The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire. Blood. 2010;116:2968-74 pubmed publisher
    ..CLL patients therefore demonstrate an expansion of the CD4(+) CMV-specific immune response, which is likely to contribute to the immunological and clinical features of this disease. ..
  21. van den Hende M, Redeker A, Kwappenberg K, Franken K, Drijfhout J, Oostendorp J, et al. Evaluation of immunological cross-reactivity between clade A9 high-risk human papillomavirus types on the basis of E6-Specific CD4+ memory T cell responses. J Infect Dis. 2010;202:1200-11 pubmed publisher
    ..Our data indicate that natural and vaccine-induced HPV16 E6-specific CD4(+) T cell responses are unlikely to mediate efficient cross-protection against other clade A9 members. ..
  22. Yue F, Lo C, Sakhdari A, Lee E, Kovacs C, Benko E, et al. HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control. J Immunol. 2010;185:498-506 pubmed publisher
    ..Thus, IL-21-producing CD4(+) T cells are induced in viremic HIV infection and likely contribute to viral control by affecting CD8(+) T cell maintenance. ..
  23. Trono D, Van Lint C, Rouzioux C, Verdin E, Barré Sinoussi F, Chun T, et al. HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science. 2010;329:174-80 pubmed publisher
  24. Schmidt Hieber M, Schwarck S, Stroux A, Ganepola S, Reinke P, Thiel E, et al. Immune reconstitution and cytomegalovirus infection after allogeneic stem cell transplantation: the important impact of in vivo T cell depletion. Int J Hematol. 2010;91:877-85 pubmed publisher
    ..01). Our data indicate that the type of in vivo TCD (alemtuzumab or ATG) differentially influences both the CMV infection risk and CD4(+)/CD8(+) T cell reconstitution kinetics in patients after allo-SCT. ..
  25. Li G, Lu G. A single low dose of dendritic cells modified with lentivirus containing a truncated neu gene can effectively suppress neu-overexpressing tumors. J Gene Med. 2010;12:604-12 pubmed publisher
  26. Gieseke F, Böhringer J, Bussolari R, Dominici M, Handgretinger R, Müller I. Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells. Blood. 2010;116:3770-9 pubmed publisher
    ..These results identify galectin-1 as the first lectin mediating the immunomodulatory effect of MSCs on allogeneic T cells...
  27. Glasmacher E, Hoefig K, Vogel K, Rath N, Du L, Wolf C, et al. Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression. Nat Immunol. 2010;11:725-33 pubmed publisher
    ..Our results support a model in which roquin controls ICOS expression through binding to the 3' UTR of ICOS mRNA and by interacting with proteins that confer post-transcriptional repression. ..
  28. Swaims A, Khani F, Zhang Y, Roberts A, Devadas S, Shi Y, et al. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood. 2010;116:2994-3003 pubmed publisher
    ..We suggest that immune activation of infected CD4(+) T cells plays an important role in the induction of Tax expression, T-cell proliferation, and pathogenesis of ATL in HTLV-1-infected individuals. ..
  29. Chen T, Cao X. Stress for maintaining memory: HSP70 as a mobile messenger for innate and adaptive immunity. Eur J Immunol. 2010;40:1541-4 pubmed publisher
    ..This study has widened our view of HSP in adaptive immunity as well as their classical functions such as APC activator and antigen carrier. ..
  30. Kovalovsky D, ALONZO E, Uche O, Eidson M, Nichols K, Sant Angelo D. PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals. J Immunol. 2010;184:6746-55 pubmed publisher
    ..These data show that PLZF is sufficient to promote T cell effector functions and that PLZF acts independently of SAP- and Fyn-mediated signaling pathways. ..
  31. Marx N, Burgmaier M, Heinz P, Ostertag M, Hausauer A, Bach H, et al. Glucagon-like peptide-1(1-37) inhibits chemokine-induced migration of human CD4-positive lymphocytes. Cell Mol Life Sci. 2010;67:3549-55 pubmed publisher
    ..This effect provides a potential novel mechanism for how GLP-1(1-37) may modulate vascular disease. ..
  32. Dias P, Giannoni F, Lee L, Han D, Yoon S, Yagita H, et al. CD4 T-cell help programs a change in CD8 T-cell function enabling effective long-term control of murine gammaherpesvirus 68: role of PD-1-PD-L1 interactions. J Virol. 2010;84:8241-9 pubmed publisher
    ..These data suggest that CD4 T-cell help programs a change in CD8 T-cell function mediated by altered PD-1 expression, which enables effective long-term control of MHV-68. ..
  33. Ellis J, Guloglu F, Tartar D, Hoeman C, Haymaker C, Cascio J, et al. APCs expressing high levels of programmed death ligand 2 sustain the development of CD4 T cell memory. J Immunol. 2010;185:3149-57 pubmed publisher
    ..These previously unrecognized findings suggest that targeting specific APCs for Ag presentation during vaccination could prove effective against microbial infections. ..
  34. Aiba Y, Kometani K, Hamadate M, Moriyama S, Sakaue Sawano A, Tomura M, et al. Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc Natl Acad Sci U S A. 2010;107:12192-7 pubmed publisher
    ..These results implicate this peri-GC region as an important site for survival and reactivation of memory B cells. ..
  35. Nuber N, Curioni Fontecedro A, Matter C, Soldini D, Tiercy J, von Boehmer L, et al. Fine analysis of spontaneous MAGE-C1/CT7-specific immunity in melanoma patients. Proc Natl Acad Sci U S A. 2010;107:15187-92 pubmed publisher
    ..This study shows that CT7 can induce specific cellular immunity in melanoma patients. Based on these findings, CT7 will be further explored as a potential vaccine for melanoma immunotherapy. ..
  36. Takao S, Ishikawa T, Yamashita K, Uchiyama T. The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells from attack by NK cells. J Immunol. 2010;185:6031-40 pubmed publisher
    ..Collectively, this study demonstrates that NK cells impact adaptive immunity through the finely controlled kinetics of HLA-E expression on T cells. Thus, HLA-E may be a new target for immunoregulation. ..
  37. Birkholz K, Schwenkert M, Kellner C, Gross S, Fey G, Schuler Thurner B, et al. Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation. Blood. 2010;116:2277-85 pubmed publisher
    ..Thus, DEC-205 targeting represents a feasible and effective method to deliver helper epitopes to DCs in anticancer vaccine strategies, which may also be suitable for DC targeting in vivo. ..
  38. Kurche J, Burchill M, Sanchez P, Haluszczak C, Kedl R. Comparison of OX40 ligand and CD70 in the promotion of CD4+ T cell responses. J Immunol. 2010;185:2106-15 pubmed publisher
    ..Thus, costimulation by CD70 or OX40L seems to be necessary for primary CD4(+) T cell responses to multiple forms of immunization, and each may make independent contributions to CD4(+) T cell priming. ..
  39. Gurkan S, Luan Y, Dhillon N, Allam S, Montague T, Bromberg J, et al. Immune reconstitution following rabbit antithymocyte globulin. Am J Transplant. 2010;10:2132-2141 pubmed publisher
    ..Collectively our data indicate that rATG alters the balance of regulatory to memory effector T cells posttransplant, providing an explanation for how it positively impacts transplant outcome. ..
  40. Rosenberg E, Graham B, Chan E, Bosch R, Stocker V, Maenza J, et al. Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infection. PLoS ONE. 2010;5:e10555 pubmed publisher
    ..Clinicaltrials.gov NCT00125099. ..
  41. Peiris J, Hui K, Yen H. Host response to influenza virus: protection versus immunopathology. Curr Opin Immunol. 2010;22:475-81 pubmed publisher
    ..Understanding pathogenesis will help develop novel therapeutic options that minimize immunopathology without impairing beneficial host defenses. ..
  42. Graham D, Akilesh H, Gmyrek G, Piccio L, Gilfillan S, Sim J, et al. ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling. Blood. 2010;116:3208-18 pubmed publisher
    ..We propose a novel mechanism for control of T helper cell priming. ..
  43. Gupta S, Garg N. Prophylactic efficacy of TcVac2 against Trypanosoma cruzi in mice. PLoS Negl Trop Dis. 2010;4:e797 pubmed publisher
    ..cruzi infection, and consequently, prevented the evolution of chronic immunopathology associated with parasite persistence in chagasic hearts. ..
  44. Wagner C, Huber S, Wirth S, Voehringer D. Chitin induces upregulation of B7-H1 on macrophages and inhibits T-cell proliferation. Eur J Immunol. 2010;40:2882-90 pubmed publisher
    ..Inhibition of T-cell proliferation was largely dependent on B7-H1, as the effect was not observed in cocultures with cells from B7-H1-deficient mice...
  45. Takimoto T, Wakabayashi Y, Sekiya T, Inoue N, Morita R, Ichiyama K, et al. Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development. J Immunol. 2010;185:842-55 pubmed publisher
    ..However, TGF-beta-mediated induction of RORgamma t, a master regulator of Th17 cell, was independent of both Smad2 and Smad3, suggesting that TGF-beta regulates Th17 development through Smad2/3-dependent and -independent mechanisms. ..
  46. Zhong Y, Cantwell A, Dube P. Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gut. Infect Immun. 2010;78:3716-25 pubmed publisher
    ..These data expand the roles of T-regs to include tempering inflammation during acute infection in addition to the well-established roles of T-regs in chronic infection, control of immune homeostasis, and autoimmune disease. ..
  47. Maurya R, Kumar R, Prajapati V, Manandhar K, Sacks D, Sundar S, et al. Human visceral leishmaniasis is not associated with expansion or accumulation of Foxp3+ CD4 cells in blood or spleen. Parasite Immunol. 2010;32:479-83 pubmed publisher
    ..We conclude that active VL is not associated with increased frequencies of peripheral Foxp3 Treg or accumulation at the site of infection. ..
  48. Giraldo Vela J, Bean A, Rudersdorf R, Wallace L, Loffredo J, Erickson P, et al. Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid. Immunogenetics. 2010;62:701-7 pubmed publisher
    ..Analysis of SIV-specific CD4+ T-cell responses elicited by a successful vaccine may have important implications in the understanding of vaccine design. ..
  49. Guri A, Mohapatra S, Horne W, Hontecillas R, Bassaganya Riera J. The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease. BMC Gastroenterol. 2010;10:60 pubmed publisher
  50. Cheng X, Wang X, Han Y, Wu Y. The expression and function of ?-1,4-galactosyltransferase-I in dendritic cells. Cell Immunol. 2010;266:32-9 pubmed publisher
    ..LA also could inhibit DC-T clustering and CD4(+) T cell proliferation. Collectively, the data suggests that GalTI might act as a key adhesion molecular participating in T cells-DCs contacts. ..
  51. Luchtefeld M, Grothusen C, Gagalick A, Jagavelu K, Schuett H, Tietge U, et al. Chemokine receptor 7 knockout attenuates atherosclerotic plaque development. Circulation. 2010;122:1621-8 pubmed publisher
  52. Burton O, Gibbs S, Miller N, Jones F, Wen L, Dunne D, et al. Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens. Eur J Immunol. 2010;40:2221-9 pubmed publisher
    ..SEA was able to enhance CD4(+) T-cell secretion of bioactive TGF-? in response to TLR2 ligand stimulation, in the absence of APC. We also show that TLR2 expressed on CD4(+) T cells was important for the Foxp3 expression induced by SEA. ..
  53. Turriziani O, Boni A, Falasca F, Graziano F, Bucci M, D Ettorre G, et al. Mutational resistance pattern of HIV type 1 in CD14+ monocytes, CD4+ T cells, and plasma from treated patients. AIDS Res Hum Retroviruses. 2010;26:625-34 pubmed publisher
    ..Hence, monocytes and other cellular reservoirs might serve as an indirect source of a drug-resistant viral variant. ..
  54. Yazdanpanah Y, Wolf L, Anglaret X, Gabillard D, Walensky R, Moh R, et al. CD4+ T-cell-guided structured treatment interruptions of antiretroviral therapy in HIV disease: projecting beyond clinical trials. Antivir Ther. 2010;15:351-61 pubmed publisher
  55. Ikebuchi R, Konnai S, Sunden Y, Onuma M, Ohashi K. Molecular cloning and expression analysis of bovine programmed death-1. Microbiol Immunol. 2010;54:291-8 pubmed publisher
    ..Further studies to characterize the functions of bovine PD-1 are therefore warranted, in order to elucidate the mechanism of the immunosuppression associated with progression of several diseases and therapy in cattle...
  56. Sanchez Burgos G, Ramos Castaneda J, Cedillo Rivera R, Dumonteil E. Immunogenicity of novel Dengue virus epitopes identified by bioinformatic analysis. Virus Res. 2010;153:113-20 pubmed publisher
  57. Bouaziz J, Calbo S, Maho Vaillant M, Saussine A, Bagot M, Bensussan A, et al. IL-10 produced by activated human B cells regulates CD4(+) T-cell activation in vitro. Eur J Immunol. 2010;40:2686-91 pubmed publisher
    ..These findings imply that manipulating IL-10 production by human B cells could be a useful therapeutic strategy for modulating immune responses in humans. ..
  58. Feng T, Wang L, Schoeb T, Elson C, Cong Y. Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J Exp Med. 2010;207:1321-32 pubmed publisher
    ..Collectively, our data demonstrate that induction of colitis requires both spontaneous proliferation of T cells driven by microbiota-derived innate signals and antigen-specific T cell proliferation. ..
  59. Karin N. The multiple faces of CXCL12 (SDF-1alpha) in the regulation of immunity during health and disease. J Leukoc Biol. 2010;88:463-73 pubmed publisher
    ..The current review explores the different biological properties of CXCL12 and discusses the implications of CXCL12-based therapies for autoimmunity and cancer diseases. ..
  60. Giroux M, Delisle J, O Brien A, Hébert M, Perreault C. T cell activation leads to protein kinase C theta-dependent inhibition of TGF-beta signaling. J Immunol. 2010;185:1568-76 pubmed publisher
    ..We propose that this process may be of vital importance upon confrontation with microbial pathogens. ..
  61. Vang A, Ben Sasson S, Dong H, KREAM B, Deninno M, Claffey M, et al. PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS ONE. 2010;5:e12011 pubmed publisher
    ..Collectively, our data identify PDE8 as a novel target for suppression of Teff cell functions, including adhesion to endothelial cells. ..
  62. Choo D, Murali Krishna K, Anita R, Ahmed R. Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help. J Immunol. 2010;185:3436-44 pubmed publisher
  63. Warnecke G, Feng G, Goto R, Nadig S, Francis R, Wood K, et al. CD4+ regulatory T cells generated in vitro with IFN-{gamma} and allogeneic APC inhibit transplant arteriosclerosis. Am J Pathol. 2010;177:464-72 pubmed publisher
    ..These data illustrate the potential of ex vivo generated regulatory T cells for the inhibition of transplant-associated vasculopathy. ..
  64. Restrepo C, Rallon N, del Romero J, Rodriguez C, Hernando V, Lopez M, et al. Low-level exposure to HIV induces virus-specific T cell responses and immune activation in exposed HIV-seronegative individuals. J Immunol. 2010;185:982-9 pubmed publisher
  65. Sonar S, Hsu Y, Conrad M, Majeau G, Kilic A, Garber E, et al. Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma. J Clin Invest. 2010;120:2767-81 pubmed publisher
  66. LeMessurier K, Hacker H, Tuomanen E, Redecke V. Inhibition of T cells provides protection against early invasive pneumococcal disease. Infect Immun. 2010;78:5287-94 pubmed publisher
    ..Our results reveal an important and adverse role of CD4(+) T cells in the pathogenesis of IPD and suggest that modulation of T-cell activation during early phases of S. pneumoniae invasive infection may provide a therapeutic option. ..
  67. Krug L, Dao T, Brown A, Maslak P, Travis W, Bekele S, et al. WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer. Cancer Immunol Immunother. 2010;59:1467-79 pubmed publisher
    ..This multivalent WT1 peptide analog vaccine induces immune responses in a high proportion of patients with thoracic malignancies with minimal toxicity. A randomized trial testing this vaccine as adjuvant therapy in MPM is planned. ..
  68. Murphy K, Stockinger B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol. 2010;11:674-80 pubmed publisher
    ..Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions. ..
  69. Morandi F, Ferretti E, Bocca P, Prigione I, Raffaghello L, Pistoia V. A novel mechanism of soluble HLA-G mediated immune modulation: downregulation of T cell chemokine receptor expression and impairment of chemotaxis. PLoS ONE. 2010;5:e11763 pubmed publisher
    ..These findings delineate a novel mechanism whereby sHLA-G modulates T cell recruitment in physiological and pathological conditions. ..
  70. Gao H, Shi W, Gong H, Wang Y, Wang Y, Xie L. Establishment of a murine model of chronic corneal allograft dysfunction. Graefes Arch Clin Exp Ophthalmol. 2010;248:1437-45 pubmed publisher
    ..Although differences between mouse strains and clinical situations remain to be explored, this murine model provides the basis for understanding the pathogenesis of CCAD. ..
  71. Uyttenhove C, Brombacher F, Van Snick J. TGF-? interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4(+) T cells. Eur J Immunol. 2010;40:2230-5 pubmed publisher
    ..As IL-9 levels were much lower in Th2 and Th17 cultures, our results identify TGF-?/IL-1 and TGF-?/IL-4 as the main control points of IL-9 synthesis. ..
  72. Sundling C, O Dell S, Douagi I, Forsell M, Mörner A, Lore K, et al. Immunization with wild-type or CD4-binding-defective HIV-1 Env trimers reduces viremia equivalently following heterologous challenge with simian-human immunodeficiency virus. J Virol. 2010;84:9086-95 pubmed publisher
  73. Prietl B, Pilz S, Wolf M, Tomaschitz A, Obermayer Pietsch B, Graninger W, et al. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases?. Isr Med Assoc J. 2010;12:136-9 pubmed
    ..Hence, our finding provides a rationale for further studies to investigate vitamin D effects on autoimmunological processes. ..
  74. Catalano A. The neuroimmune semaphorin-3A reduces inflammation and progression of experimental autoimmune arthritis. J Immunol. 2010;185:6373-83 pubmed publisher
  75. Stumhofer J, Tait E, Quinn W, Hosken N, Spudy B, Goenka R, et al. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat Immunol. 2010;11:1119-26 pubmed publisher
    ..Thus, IL-27p28, as a natural antagonist of gp130-mediated signaling, may be useful as a therapeutic for managing inflammation mediated by cytokines that signal through gp130. ..
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    ..These data favor starting ART no longer than one week after intravenous SIV(mac251) exposure. ..
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    ..58) and greater severity of AR episodes (r=-0.56) after 1 year posttransplantation. Increased serum HLA-G levels track with operational tolerance of liver grafts and support favorable outcomes in pediatric and young adult recipients. ..
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    ..Dimeric MHC class II-peptide chimeras-like approach may provide rational grounds for the development of more efficient antigen-specific therapies in type 1 diabetes. ..
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    ..This review will focus on recent advances in understanding the immune mechanisms of HIV control, and on the lessons that may be drawn for the development of candidate HIV vaccines. ..
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    ..Collectively, these data demonstrate the utility of SA-4-1BBL as a new class of multifunctional immunomodulator for the development of therapeutic vaccines against cancer and chronic infections. ..
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    ..Our findings show that CP-690,550 effectively inhibits Teff function but preserves the suppressive activity of CD4(+)CD25(bright) regulatory T cells. ..
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    ..We suggest that the pharmacological modulation of DC maturation has the potential to shape the quality of the adaptive immune response and could be exploited for the treatment of inflammation-related diseases. ..
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    ..Therefore, this peptide can be used as a lead for developing novel HIV fusion inhibitors and as a probe for studying the membrane-fusogenic mechanism of HIV. ..
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    ..001). Both the extent of immune depletion prior to ART and IL-7R? haplotype 2 are important determinants of time to CD4(+) T cell recovery to counts of >500 cells/?L. ..
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    ..The observation suggests an important surveillance role for the immune system against premalignant intestinal lesions in patients with long-standing ulcerative colitis. ..
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    ..pylori. All the data offer new possibilities that Foxp3 gene may be the new target of immunization intervention strategies for eradication of H. pylori. ..