antigen presenting cells

Summary

Summary: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.

Top Publications

  1. Anderson K, Allen R. Regulation of T-cell immunity by leucocyte immunoglobulin-like receptors: innate immune receptors for self on antigen-presenting cells. Immunology. 2009;127:8-17 pubmed publisher
    ..We discuss the relevance of LILR-mediated immune regulation across a range of scenarios from autoimmunity to transplant medicine, infection and cancer...
  2. Shih D, Kwan L, Chavez V, Cohavy O, Gonsky R, Chang E, et al. Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. Eur J Immunol. 2009;39:3239-50 pubmed publisher
    ..Our findings suggest a role for TL1A in pro-inflammatory APC-T cell interactions and implicate TL1A in host responses to enteric microorganisms...
  3. Sokol C, Chu N, Yu S, Nish S, Laufer T, Medzhitov R. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol. 2009;10:713-20 pubmed publisher
    ..Thus, basophils function as antigen-presenting cells for T(H)2 differentiation in response to protease allergens...
  4. Wigren M, Bengtsson D, Dunér P, Olofsson K, Bjorkbacka H, Bengtsson E, et al. Atheroprotective effects of Alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells. Circ Res. 2009;104:e62-70 pubmed publisher
  5. Hartman N, Nye J, Groves J. Cluster size regulates protein sorting in the immunological synapse. Proc Natl Acad Sci U S A. 2009;106:12729-34 pubmed publisher
    ..We discuss a sorting mechanism, based on frictional coupling to the actin cytoskeleton, that is consistent with these observations and is, in principle, extendable to all cell surface proteins in the synapse...
  6. Sato F, Nakazawa M, Yamamiya S, Tamura C, Hongo N, Hotta C, et al. Effect of BSA antigen sensitization during the acute phase of influenza A viral infection on CD11c+ pulmonary antigen presenting cells. Allergol Int. 2009;58:445-54 pubmed publisher
    Influenza A viral infection is concerned with induction of asthma. CD11c+ pulmonary antigen presenting cells (APCs) play a central role in sensitization with inhaled antigens during the acute phase of influenza A viral infection and also ..
  7. Maddur M, Kaveri S, Bayry J. Basophils as antigen presenting cells. Trends Immunol. 2010;31:45-8 pubmed publisher
    Recent reports demonstrate that basophils act as antigen presenting cells to drive Th2 and IgE responses against protease and protein allergens and helminth parasites...
  8. Jung S, Park Y, Lee H, Shin J, Lee G, Park S. TGF-beta-treated antigen presenting cells suppress collagen- induced arthritis through the promotion of Th2 responses. Exp Mol Med. 2010;42:187-94 pubmed
    ..Our results suggest that in vitro-generated Tol-APCs have potential therapeutic value for the treatment of rheumatoid arthritis as well as other autoimmune diseases...
  9. Au R, Jedlicka A, Li W, Pekosz A, Klein S. Seoul virus suppresses NF-kappaB-mediated inflammatory responses of antigen presenting cells from Norway rats. Virology. 2010;400:115-27 pubmed publisher
    ..To address whether hantaviruses alter the maturation and functional activity of antigen presenting cells (APCs), rat bone marrow-derived dendritic cells (BMDCs) and macrophages (BMDMs) were generated and ..
  10. Sinha S, Miller L, Subramanian S, McCarty O, Proctor T, Meza Romero R, et al. Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010;225:52-61 pubmed publisher
    ..These results demonstrate a novel pathway of T cell regulation by RTL-bound APCs...

Detail Information

Publications157 found, 100 shown here

  1. Anderson K, Allen R. Regulation of T-cell immunity by leucocyte immunoglobulin-like receptors: innate immune receptors for self on antigen-presenting cells. Immunology. 2009;127:8-17 pubmed publisher
    ..We discuss the relevance of LILR-mediated immune regulation across a range of scenarios from autoimmunity to transplant medicine, infection and cancer...
  2. Shih D, Kwan L, Chavez V, Cohavy O, Gonsky R, Chang E, et al. Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells. Eur J Immunol. 2009;39:3239-50 pubmed publisher
    ..Our findings suggest a role for TL1A in pro-inflammatory APC-T cell interactions and implicate TL1A in host responses to enteric microorganisms...
  3. Sokol C, Chu N, Yu S, Nish S, Laufer T, Medzhitov R. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol. 2009;10:713-20 pubmed publisher
    ..Thus, basophils function as antigen-presenting cells for T(H)2 differentiation in response to protease allergens...
  4. Wigren M, Bengtsson D, Dunér P, Olofsson K, Bjorkbacka H, Bengtsson E, et al. Atheroprotective effects of Alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells. Circ Res. 2009;104:e62-70 pubmed publisher
  5. Hartman N, Nye J, Groves J. Cluster size regulates protein sorting in the immunological synapse. Proc Natl Acad Sci U S A. 2009;106:12729-34 pubmed publisher
    ..We discuss a sorting mechanism, based on frictional coupling to the actin cytoskeleton, that is consistent with these observations and is, in principle, extendable to all cell surface proteins in the synapse...
  6. Sato F, Nakazawa M, Yamamiya S, Tamura C, Hongo N, Hotta C, et al. Effect of BSA antigen sensitization during the acute phase of influenza A viral infection on CD11c+ pulmonary antigen presenting cells. Allergol Int. 2009;58:445-54 pubmed publisher
    Influenza A viral infection is concerned with induction of asthma. CD11c+ pulmonary antigen presenting cells (APCs) play a central role in sensitization with inhaled antigens during the acute phase of influenza A viral infection and also ..
  7. Maddur M, Kaveri S, Bayry J. Basophils as antigen presenting cells. Trends Immunol. 2010;31:45-8 pubmed publisher
    Recent reports demonstrate that basophils act as antigen presenting cells to drive Th2 and IgE responses against protease and protein allergens and helminth parasites...
  8. Jung S, Park Y, Lee H, Shin J, Lee G, Park S. TGF-beta-treated antigen presenting cells suppress collagen- induced arthritis through the promotion of Th2 responses. Exp Mol Med. 2010;42:187-94 pubmed
    ..Our results suggest that in vitro-generated Tol-APCs have potential therapeutic value for the treatment of rheumatoid arthritis as well as other autoimmune diseases...
  9. Au R, Jedlicka A, Li W, Pekosz A, Klein S. Seoul virus suppresses NF-kappaB-mediated inflammatory responses of antigen presenting cells from Norway rats. Virology. 2010;400:115-27 pubmed publisher
    ..To address whether hantaviruses alter the maturation and functional activity of antigen presenting cells (APCs), rat bone marrow-derived dendritic cells (BMDCs) and macrophages (BMDMs) were generated and ..
  10. Sinha S, Miller L, Subramanian S, McCarty O, Proctor T, Meza Romero R, et al. Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010;225:52-61 pubmed publisher
    ..These results demonstrate a novel pathway of T cell regulation by RTL-bound APCs...
  11. Gleissner C, Dengler T. Induction of ILT expression on nonprofessional antigen presenting cells: Clinical applications. Hum Immunol. 2009;70:357-9 pubmed
    ..We here review mechanisms and effects of ILT3/ILT4 upregulation on endothelial cells and their potential significance in solid organ transplantation...
  12. Kang H, Choi T, Ahn K, Lee J, Ham I, Choi H, et al. Upregulation of interferon-gamma and interleukin-4, Th cell-derived cytokines by So-Shi-Ho-Tang (Sho-Saiko-To) occurs at the level of antigen presenting cells, but not CD4 T cells. J Ethnopharmacol. 2009;123:6-14 pubmed publisher
    ..So-Shi-Ho-Tang (SSHT) or known as Sho-Saiko-To in Japanese and Xiao-Chai-Hu-Tang in Chinese has been used to treat chronic liver disease and other infections, and its hepatoprotective effects have been widely studied...
  13. Toth A, Szilágyi O, Krasznai Z, Panyi G, Hajdu P. Functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse. Immunol Lett. 2009;125:15-21 pubmed publisher
    Formation of immunological synapse (IS), the interface between T cells and antigen presenting cells, is a crucial step in T cell activation...
  14. MacDonald T, Vossenkamper A, Voessenkamper A, Di Sabatino A. Antigen presenting cells and T cell interactions in the gastrointestinal tract. Mol Nutr Food Res. 2009;53:947-51 pubmed publisher
    ..We present evidence that type I INF made by plasmacytoid dendritic cells may be important in coeliac disease...
  15. Dorhoi A, Kaufmann S. Fine-tuning of T cell responses during infection. Curr Opin Immunol. 2009;21:367-77 pubmed publisher
    ..This review focuses on the multiple mechanisms that govern T cell differentiation during infection...
  16. Wang J, Li B. [Phenotype expression and function of antigen presenting cells in huaman gammadelta T cells activated by peptide antigen from Mycobacterium tuberculosis]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009;25:588-91 pubmed
    ..To explore whether the human peripheral gammadelta T cells stimulated by polypeptide heat resistant antigen from Mycobacterium tuberculosis (Mtb-HAg) express phenotype and have the fuction of antigen presentation...
  17. Palomaki J, Karisola P, Pylkkanen L, Savolainen K, Alenius H. Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells. Toxicology. 2010;267:125-31 pubmed publisher
    ..In this study we explored immunological effects of five different nanomaterials on antigen presenting cells (APC) in vitro...
  18. Shields J, Kourtis I, Tomei A, Roberts J, Swartz M. Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21. Science. 2010;328:749-52 pubmed publisher
    ..We suggest that by altering the tumor microenvironment, CCL21-secreting tumors shift the host immune response from immunogenic to tolerogenic, which facilitates tumor progression...
  19. Brown L, Kelso A. Prospects for an influenza vaccine that induces cross-protective cytotoxic T lymphocytes. Immunol Cell Biol. 2009;87:300-8 pubmed publisher
    ..Application of these principles to the next generation of influenza vaccines should lead to much greater control of infection...
  20. Webb T, Bieler J, Schneck J, Oelke M. Ex vivo induction and expansion of natural killer T cells by CD1d1-Ig coated artificial antigen presenting cells. J Immunol Methods. 2009;346:38-44 pubmed publisher
    ..Importantly, CD1d-Ig aAPC can expand NKT cells from cancer patients. Thus, CD1d-expressing aAPC will enhance our knowledge of NKT cell biology and could potentially be used as a novel tool in adoptive immunotherapeutic strategies...
  21. Weber C, Drogoz A, David L, Domard A, Charles M, Verrier B, et al. Polysaccharide-based vaccine delivery systems: Macromolecular assembly, interactions with antigen presenting cells, and in vivo immunomonitoring. J Biomed Mater Res A. 2010;93:1322-34 pubmed publisher
    ..b>Antigen presenting cells [dendritic cells (DCs)], obtained from monocytes, could internalize the colloids...
  22. Fievet N, Varani S, Ibitokou S, Briand V, Louis S, Perrin R, et al. Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells. Malar J. 2009;8:251 pubmed publisher
  23. Gonzalez M, Plummer E, Rae C, Manchester M. Interaction of Cowpea mosaic virus (CPMV) nanoparticles with antigen presenting cells in vitro and in vivo. PLoS ONE. 2009;4:e7981 pubmed publisher
    ..In particular, it is important to understand the interactions of a potential vaccine with antigen presenting cells (APCs) of the immune system...
  24. Rescigno M. Functional specialization of antigen presenting cells in the gastrointestinal tract. Curr Opin Immunol. 2010;22:131-6 pubmed publisher
    ..players in these responses, including dendritic cells, macrophages, B cells and basophils as professional antigen presenting cells (APCs), and stromal cells and epithelial cells as non-professional APCs...
  25. Bahbouhi B, Pettré S, Berthelot L, Garcia A, Elong Ngono A, Degauque N, et al. T cell recognition of self-antigen presenting cells by protein transfer assay reveals a high frequency of anti-myelin T cells in multiple sclerosis. Brain. 2010;133:1622-36 pubmed publisher
    ..T cells in a new approach based on their combined ability to acquire membrane proteins from autologous antigen presenting cells, and to respond to whole myelin extract as the stimulating autoantigen...
  26. Duriancik D, Lackey D, Hoag K. Vitamin A as a regulator of antigen presenting cells. J Nutr. 2010;140:1395-9 pubmed publisher
    ..Previously, the focus of vitamin A action in adaptive immunity was on lymphocytes, but these recent advances suggest the APC may be the central player in carrying out the immune system functions of vitamin A...
  27. Gottfried Blackmore A, Kaunzner U, Idoyaga J, Felger J, McEwen B, Bulloch K. Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells. Proc Natl Acad Sci U S A. 2009;106:20918-23 pubmed publisher
    Dendritic cells (DC) are the professional antigen presenting cells (APC) that bridge the innate and adaptive immune system...
  28. Khanna K, Aguila C, Redman J, Suarez Ramirez J, Lefrancois L, Cauley L. In situ imaging reveals different responses by naïve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection. Eur J Immunol. 2008;38:3304-15 pubmed publisher
    ..A high frequency of endogenous NP-specific CD8 T cells in the MLN indicates that late antigen presentation may help shape the epitope dominance hierarchy during reinfection...
  29. Sarikonda G, Wang H, Puan K, Liu X, Lee H, Song Y, et al. Photoaffinity antigens for human gammadelta T cells. J Immunol. 2008;181:7738-50 pubmed
    ..Taken together, these results suggest that nonpeptide Ags are presented by a novel-Ag-presenting molecule that is widely distributed and nonpolymorphic, but not classical MHC class I, MHC class II, or CD1...
  30. Gilfillan S, Chan C, Cella M, Haynes N, Rapaport A, Boles K, et al. DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med. 2008;205:2965-73 pubmed publisher
  31. Wu M, Zhao H, Li M, Yue Y, Xiong S, Xu W. Intranasal Vaccination with Mannosylated Chitosan Formulated DNA Vaccine Enables Robust IgA and Cellular Response Induction in the Lungs of Mice and Improves Protection against Pulmonary Mycobacterial Challenge. Front Cell Infect Microbiol. 2017;7:445 pubmed publisher
    ..tb). To facilitate airway delivery and antigen targeting to the antigen presenting cells in the alveoli, we employed mannosylated chitosan (MCS) to formulate a multi-T-epitope DNA vaccine, pPES, ..
  32. Conus S, Simon H. Cathepsins and their involvement in immune responses. Swiss Med Wkly. 2010;140:w13042 pubmed publisher
    ..Within the immune response, endo-lysosomal proteases play a key role. In this review we cover specific roles of cathepsins in innate and adaptive immunity, as well as their implication in the pathogenesis of several diseases. ..
  33. Doherty D. Immunity, tolerance and autoimmunity in the liver: A comprehensive review. J Autoimmun. 2016;66:60-75 pubmed publisher
    ..Here I review the cellular mechanisms by which hepatic antigen-presenting cells and innate lymphocytes control the balance between immunity, tolerance and autoimmunity in the liver. ..
  34. Park E, Oh S, Lee S, Lee K, Kim Y, Lee B, et al. Chronic pulmonary accumulation of iron oxide nanoparticles induced Th1-type immune response stimulating the function of antigen-presenting cells. Environ Res. 2015;143:138-47 pubmed publisher
    ..Taken together, we suggest that chronic pulmonary accumulation of FeNPs may induce Th1-polarized immune response augmenting the function of antigen-presenting cells in the lung. ..
  35. Constantino J, Gomes C, Falcão A, Neves B, Cruz M. Dendritic cell-based immunotherapy: a basic review and recent advances. Immunol Res. 2017;65:798-810 pubmed publisher
    ..Finally, future perspectives for this emerging field are highlighted. ..
  36. Andersen T, Zhou F, Cox R, Bogen B, Grødeland G. A DNA Vaccine That Targets Hemagglutinin to Antigen-Presenting Cells Protects Mice against H7 Influenza. J Virol. 2017;91: pubmed publisher
    ..Vaccine efficacy was contingent on targeting of the secreted vaccine protein to antigen-presenting cells. ..
  37. Lopes N, Charaix J, Cédile O, Sergé A, Irla M. Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells. Nat Commun. 2018;9:1262 pubmed publisher
    ..Altogether, this study identifies a fine-tuning mechanism of T cell repertoire selection and paves the way for therapeutic interventions to treat autoimmune disorders. ..
  38. Brown D, Jones D, Anderson K, Lapaque N, Buerki R, Trowsdale J, et al. The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection. BMC Immunol. 2009;10:56 pubmed publisher
    ..High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic antigen presenting cells and has been observed in cancer and transplant situations...
  39. Sehrawat S, Koenig P, Kirak O, Schlieker C, Fankhauser M, Ploegh H. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood. 2013;121:1145-56 pubmed publisher
    b>Antigen presenting cells (APCs) that express a catalytically inactive version of the deubiquitylase YOD1 (YOD1-C160S) present exogenous antigens more efficiently to CD8(+) T cells, both in vitro and in vivo...
  40. Etemire E, Krull M, Hasenberg M, Reichardt P, Gunzer M. Transiently reduced PI3K/Akt activity drives the development of regulatory function in antigen-stimulated Naïve T-cells. PLoS ONE. 2013;8:e68378 pubmed publisher
    ..CD4+ CD25+ FoxP3- iTreg induction during antigen-specific T-cell receptor (TCR) stimulation with weak antigen presenting cells (APC)...
  41. Garg A, Romano E, Rufo N, Agostinis P. Immunogenic versus tolerogenic phagocytosis during anticancer therapy: mechanisms and clinical translation. Cell Death Differ. 2016;23:938-51 pubmed publisher
  42. Laksono B, Grosserichter Wagener C, de Vries R, Langeveld S, Brem M, van Dongen J, et al. In Vitro Measles Virus Infection of Human Lymphocyte Subsets Demonstrates High Susceptibility and Permissiveness of both Naive and Memory B Cells. J Virol. 2018;92: pubmed publisher
    ..The highest infection levels were detected in plasma cells and germinal center B cells, suggesting that infection and depletion of these populations contribute to reduced host resistance. ..
  43. Boks M, Zwaginga J, van Ham S, ten Brinke A. An optimized CFSE-based T-cell suppression assay to evaluate the suppressive capacity of regulatory T-cells induced by human tolerogenic dendritic cells. Scand J Immunol. 2010;72:158-68 pubmed publisher
  44. Kukkonen S, Martinez Viedma M, Kim N, Manrique M, Aldovini A. HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells. Retrovirology. 2014;11:30 pubmed publisher
    ..that the second exon of Tat is critical to the containment of the innate response stimulated by Tat in antigen presenting cells and support a role for Tat in stimulating cellular transcription via its interaction with transcription ..
  45. Assas B, Wakid M, Zakai H, Miyan J, Pennock J. Transient receptor potential vanilloid 1 expression and function in splenic dendritic cells: a potential role in immune homeostasis. Immunology. 2016;147:292-304 pubmed publisher
    ..We suggest that dendritic cell responses to neural ligands can amplify neuropeptide release, but more importantly that variability in CGRP release across individuals may have important implications for immune cell homeostasis. ..
  46. Tiper I, Temkin S, Spiegel S, Goldblum S, Giuntoli R, Oelke M, et al. VEGF Potentiates GD3-Mediated Immunosuppression by Human Ovarian Cancer Cells. Clin Cancer Res. 2016;22:4249-58 pubmed publisher
    ..These studies suggest that the combination of immune modulation with antiangiogenic treatment has therapeutic potential in ovarian cancer. Clin Cancer Res; 22(16); 4249-58. ©2016 AACR. ..
  47. Anghelina D, Lam E, Falck Pedersen E. Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. J Virol. 2016;90:5915-27 pubmed publisher
  48. Goverman J. Autoimmune T cell responses in the central nervous system. Nat Rev Immunol. 2009;9:393-407 pubmed publisher
    ..This Review focuses on recent progress in delineating the pathogenic mechanisms, regulation and interplay between these different T cell subsets in CNS autoimmunity. ..
  49. Mascarell L, Lombardi V, Zimmer A, Louise A, Tourdot S, Van Overtvelt L, et al. Mapping of the lingual immune system reveals the presence of both regulatory and effector CD4+ T cells. Clin Exp Allergy. 2009;39:1910-9 pubmed publisher
    ..No NK, NK-T, gamma/delta, CD8(+) T cells, nor B-lymphocytes were detected. Potential antigen presenting cells include various subsets of dendritic cells (CD207(+) Langerhans cells, CD11b(+)CD11c(+) myeloid cells and ..
  50. Rai R, Das B, Choudhary N, Talukdar A, Rao D. MAP of F1 and V antigens from Yersinia pestis astride innate and adaptive immune response. Microb Pathog. 2015;87:13-20 pubmed publisher
    ..Dendritic cells and macrophages are important antigen presenting cells for effective immune response...
  51. Novelli R, Gagliardini E, Ruggiero B, Benigni A, Remuzzi G. Any value of podocyte B7-1 as a biomarker in human MCD and FSGS?. Am J Physiol Renal Physiol. 2016;310:F335-41 pubmed publisher
    ..In conclusion, since B7-1 is not induced in podocyte of MCD and FSGS patients, the antiproteinuric action of abatacept, if confirmed, may not be the result of an effect on podocyte B7-1. ..
  52. Herrera M, Söderberg M, Sabirsh A, Valastro B, Mölne J, Santamaria B, et al. Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease. Am J Physiol Renal Physiol. 2017;312:F748-F759 pubmed publisher
    ..Interaction of B7-1 (CD80) on the surface of antigen presenting cells with its binding partners, CTLA4 (CD152) and CD28 on T-cells, is essential for T-cell activation...
  53. Gautron A, Giquel B, Beaudoin L, Autrusseau E, Speak A, Platt F, et al. Invariant NKT cells in adrenoleukodystrophy patients and mice. J Neuroimmunol. 2010;229:204-11 pubmed publisher
    ..In ALD patients, but not in ALD deficient mice, iNKT cell frequency and CD1d expression on the surface of B cells are slightly decreased. However, such minor differences might not influence the pathogenesis of the disease. ..
  54. Fromen C, Rahhal T, Robbins G, Kai M, Shen T, Luft J, et al. Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells. Nanomedicine. 2016;12:677-687 pubmed publisher
    ..In this article, the authors investigated the interaction of nanoparticles with various types of lung antigen presenting cells in an attempt to understand the cellular mechanisms...
  55. Wu Y, Pfeifer A, Myschetzky R, Garbyal R, Rasmussen P, Knigge U, et al. Induction of Anti-Tumor Immune Responses by Peptide Receptor Radionuclide Therapy with (177)Lu-DOTATATE in a Murine Model of a Human Neuroendocrine Tumor. Diagnostics (Basel). 2013;3:344-55 pubmed publisher
    ..model of human NETs, we showed that (177)Lu-DOTATATE PRRT led to increased infiltration of CD86+ antigen presenting cells into tumor tissue...
  56. Liu Z, Zhou H, Wang W, Fu Y, Zhu M. A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice. Oncoimmunology. 2016;5:e1147641 pubmed publisher
    ..Dendritic cells (DCs) are probably the most potent antigen presenting cells for the induction of cytotoxic T lymphocyte (CTL) response, which is crucial for tumor control...
  57. Son H, Jeon Y, Chung J, Kim C. In vivo monitoring of transfected DNA, gene expression kinetics, and cellular immune responses in mice immunized with a human NIS gene-expressing plasmid. Int J Immunopathol Pharmacol. 2016;29:612-625 pubmed
    ..Furthermore, sequential presentation of NIS DNA to T-cells by migratory antigen presenting cells could induce NIS DNA-specific Th1 immune responses and thus retard the growth of NIS-expressing tumors.
  58. Chiba A, Tamura N, Yoshikiyo K, Murayama G, Kitagaichi M, Yamaji K, et al. Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus. Arthritis Res Ther. 2017;19:58 pubmed publisher
    ..These results suggest that MAIT cells reflect the pathological condition of SLE and that their activated status correlates with presence of disease. ..
  59. van Eden W. Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes. Philos Trans R Soc Lond B Biol Sci. 2018;373: pubmed publisher
    ..This article is part of the theme issue 'Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective'. ..
  60. Zhang M, Racine J, Lin Q, Liu Y, Tang S, Qin Q, et al. MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice. Proc Natl Acad Sci U S A. 2018;115:E2329-E2337 pubmed publisher
    ..autoreactive T cells that have T-cell receptor (TCR) recognizing (cross-reacting with) donor-type antigen presenting cells (APCs), which have come to reside in the thymus...
  61. Gonzalez S, Pitcher L, MEMPEL T, Schuerpf F, Carroll M. B cell acquisition of antigen in vivo. Curr Opin Immunol. 2009;21:251-7 pubmed publisher
    ..Thus, the follicular conduits provide an 'antigen highway' for B cells trafficking within the LN. These new findings provide an important discovery in understanding how B cells acquire cognate antigen. ..
  62. Vogt B, Warncke M, Micheel B, Sheriff A. Lentiviral gene transfer of CTLA4 generates B cells with reduced costimulatory properties. Autoimmunity. 2009;42:380-2 pubmed
    ..We show that B cells with reduced B7 expression reduce the antigen (Ag) specific TC proliferation in vitro. B cells expressing an ER-directed CTLA4 may reduce Ag-specific immune responses. ..
  63. de Riva A, Deery M, McDonald S, Lund T, Busch R. Measurement of protein synthesis using heavy water labeling and peptide mass spectrometry: Discrimination between major histocompatibility complex allotypes. Anal Biochem. 2010;403:1-12 pubmed publisher
    ..It simplifies measurements of protein synthesis, enabling novel applications in physiology, in genotype/phenotype interactions, and potentially in kinetic proteomics...
  64. Bertrand F, Esquerré M, Petit A, Rodrigues M, Duchez S, Delon J, et al. Activation of the ancestral polarity regulator protein kinase C zeta at the immunological synapse drives polarization of Th cell secretory machinery toward APCs. J Immunol. 2010;185:2887-94 pubmed publisher
    ..Our results identify the PKCzeta signaling pathway as a key component of the Th cell polarization machinery and provide a molecular basis for T cell-dedicated activation of cognate DCs. ..
  65. Bradley J, Stein R, Randolph B, Molina E, Arnold J, Gregg R. T cell resistance to activation by dendritic cells requires long-term culture in simulated microgravity. Life Sci Space Res (Amst). 2017;15:55-61 pubmed publisher
    ..T cells are activated upon recognition of specific microbial peptides bound on the surface of antigen presenting cells, such as dendritic cells (DC)...
  66. Zhou D, Li P, Lin Y, Lott J, Hislop A, Canaday D, et al. Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens. Immunity. 2005;22:571-81 pubmed
    ..before binding MHC class II molecules within endosomal and lysosomal compartments of professional antigen presenting cells (APC) for subsequent presentation to T cells...
  67. Inoue K, Koike E, Yanagisawa R, Hirano S, Nishikawa M, Takano H. Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model. Toxicol Appl Pharmacol. 2009;237:306-16 pubmed publisher
    ..In addition, the exacerbation may be partly through the inappropriate activation of antigen-presenting cells including DC. ..
  68. GeurtsvanKessel C, Bergen I, Muskens F, Boon L, Hoogsteden H, Osterhaus A, et al. Both conventional and interferon killer dendritic cells have antigen-presenting capacity during influenza virus infection. PLoS ONE. 2009;4:e7187 pubmed publisher
    ..In conclusion, we found evidence for APC function of lung NK cells during influenza infection, but this is a feature not exclusive to the IKDC subset. ..
  69. Awe J, Gschweng E, Vega Crespo A, Voutila J, Williamson M, Truong B, et al. Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives. Stem Cells Transl Med. 2015;4:136-45 pubmed publisher
    ..Neither of the previous immunogenicity-associated genes in the mouse currently appears to be relevant in a human context. ..
  70. Digre A, Singh K, Abrink M, Reijmers R, Sandler S, Vlodavsky I, et al. Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis. Sci Rep. 2017;7:46229 pubmed publisher
    ..and adaptive immune responses of the Hpa-tg mice, reflected by increased proportions of macrophages, antigen presenting cells and plasmacytoid dendritic cells as well as Helios-positive CD4+ and CD8+ T cells...
  71. Chen X, Poncette L, Blankenstein T. Human TCR-MHC coevolution after divergence from mice includes increased nontemplate-encoded CDR3 diversity. J Exp Med. 2017;214:3417-3433 pubmed publisher
    ..Our data, which demonstrate human TCR-MHC coevolution after divergence from rodents, explain the greater T cell diversity in humans and suggest a mechanism for ensuring that any V-J gene combination can be selected by a single MHC II. ..
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  93. Iwabuchi N, Takahashi N, Xiao J, Yonezawa S, Yaeshima T, Iwatsuki K, et al. Suppressive effects of Bifidobacterium longum on the production of Th2-attracting chemokines induced with T cell-antigen-presenting cell interactions. FEMS Immunol Med Microbiol. 2009;55:324-34 pubmed publisher
    ..These results indicate that BB536 suppresses the production of Th2-attracting chemokines induced by the T cell-APC interaction, suggesting a novel mechanism for alleviating symptoms of allergic disorders by probiotics. ..
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    ..Our results highlight the versatility of retrovirus-derived VLP design and the value of using ncRNA as an intrinsic vaccine adjuvant. ..
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    ..We conclude that B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes. ..
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    ..Our data implicate a role for the alpha7 nAChR in immune modulation and suggest that alpha7 nAChR agonists may be effective in the treatment of inflammatory disorders. ..