aortic valve

Summary

Summary: The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.

Top Publications

  1. Linefsky J, O Brien K, Katz R, De Boer I, Barasch E, Jenny N, et al. Association of serum phosphate levels with aortic valve sclerosis and annular calcification: the cardiovascular health study. J Am Coll Cardiol. 2011;58:291-7 pubmed publisher
    This study was conducted to evaluate mineral metabolism markers as potential risk factors for calcific aortic valve disease...
  2. Roos C, Hagler M, Zhang B, Oehler E, Arghami A, Miller J. Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice. Am J Physiol Heart Circ Physiol. 2013;305:H1428-39 pubmed publisher
    ..The purpose of this study was to characterize changes in antioxidant and age-related gene expression in aorta and aortic valve with aging, and test the hypothesis that increased mitochondrial oxidative stress accelerates age-related ..
  3. Krishnamurthy V, Opoka A, Kern C, Guilak F, Narmoneva D, Hinton R. Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease. Matrix Biol. 2012;31:197-205 pubmed publisher
    b>Aortic valve disease (AVD) occurs in 2.5% of the general population and often requires surgical intervention. Aortic valve malformation (AVM) underlies the majority of cases, suggesting a developmental etiology...
  4. Ferrari E, von Segesser L. Transcatheter aortic valve implantation (TAVI): state of the art techniques and future perspectives. Swiss Med Wkly. 2010;140:w13127 pubmed publisher
    Transcatheter aortic valve therapies are the newest established techniques for the treatment of high risk patients affected by severe symptomatic aortic valve stenosis...
  5. Leppikangas H, Järvelä K, Sisto T, Maaranen P, Virtanen M, Lehto P, et al. Preoperative levosimendan infusion in combined aortic valve and coronary bypass surgery. Br J Anaesth. 2011;106:298-304 pubmed publisher
    ..Levosimendan improved haemodynamics compared with a placebo in patients undergoing high-risk cardiac surgery. The concentrations of levosimendan's metabolites were higher compared with earlier studies using perioperative dosing. ..
  6. Bissell M, Hess A, Biasiolli L, Glaze S, Loudon M, Pitcher A, et al. Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type. Circ Cardiovasc Imaging. 2013;6:499-507 pubmed publisher
    Ascending aortic dilation is important in bicuspid aortic valve (BAV) disease, with increased risk of aortic dissection...
  7. Bosse K, Hans C, Zhao N, Koenig S, Huang N, Guggilam A, et al. Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease. J Mol Cell Cardiol. 2013;60:27-35 pubmed publisher
    The mature aortic valve is composed of a structured trilaminar extracellular matrix that is interspersed with aortic valve interstitial cells (AVICs) and covered by endothelium...
  8. Abdel Wahab M, Mehilli J, Frerker C, Neumann F, Kurz T, Tölg R, et al. Comparison of balloon-expandable vs self-expandable valves in patients undergoing transcatheter aortic valve replacement: the CHOICE randomized clinical trial. JAMA. 2014;311:1503-14 pubmed publisher
    Transcatheter aortic valve replacement (TAVR) is an effective treatment option for high-risk patients with severe aortic stenosis...
  9. Chopard R, Meneveau N, Chocron S, Gilard M, Laskar M, Eltchaninoff H, et al. Impact of chronic obstructive pulmonary disease on Valve Academic Research Consortium-defined outcomes after transcatheter aortic valve implantation (from the FRANCE 2 Registry). Am J Cardiol. 2014;113:1543-9 pubmed publisher
    ..disease (COPD) on Valve Academic Research Consortium-defined outcomes in patients undergoing transcatheter aortic valve implantation (TAVI)...

More Information

Publications32

  1. Cai Z, Li F, Gong W, Liu W, Duan Q, Chen C, et al. Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals. Arterioscler Thromb Vasc Biol. 2013;33:2345-54 pubmed publisher
    b>Aortic valve (AV) calcification occurs via a pathophysiological process that includes lipoprotein deposition, inflammation, and osteoblastic differentiation of valvular interstitial cells...
  2. Clavel M, Messika Zeitoun D, Pibarot P, Aggarwal S, Malouf J, Araoz P, et al. The complex nature of discordant severe calcified aortic valve disease grading: new insights from combined Doppler echocardiographic and computed tomographic study. J Am Coll Cardiol. 2013;62:2329-38 pubmed publisher
    With concomitant Doppler echocardiography and multidetector computed tomography (MDCT) measuring aortic valve calcification (AVC) load, this study aimed at defining: 1) independent physiologic/structural determinants of aortic valve area (..
  3. Das D, Holmes A, Murphy G, Mishra K, Rosenkranz A, Horowitz J, et al. TGF-beta1-Induced MAPK activation promotes collagen synthesis, nodule formation, redox stress and cellular senescence in porcine aortic valve interstitial cells. J Heart Valve Dis. 2013;22:621-30 pubmed
    b>Aortic valve stenosis is a major cause of valve replacement, particularly in the elderly. TGF-beta1 is upregulated in stenotic valves and induces calcification and collagen synthesis in cultured valve interstitial cells...
  4. Jilaihawi H, Doctor N, Kashif M, Chakravarty T, Rafique A, Makar M, et al. Aortic annular sizing for transcatheter aortic valve replacement using cross-sectional 3-dimensional transesophageal echocardiography. J Am Coll Cardiol. 2013;61:908-16 pubmed publisher
    ..TEE) to two-dimensional (2D) TEE as methods for predicting aortic regurgitation after transcatheter aortic valve replacement (TAVR)...
  5. Huk D, Hammond H, Kegechika H, Lincoln J. Increased dietary intake of vitamin A promotes aortic valve calcification in vivo. Arterioscler Thromb Vasc Biol. 2013;33:285-93 pubmed publisher
    Calcific aortic valve disease (CAVD) is a major public health problem with no effective treatment available other than surgery...
  6. Yamamoto M, Meguro K, Mouillet G, Bergoend E, Monin J, Lim P, et al. Effect of local anesthetic management with conscious sedation in patients undergoing transcatheter aortic valve implantation. Am J Cardiol. 2013;111:94-9 pubmed publisher
    ..sought to assess the effectiveness of local anesthesia with conscious sedation (LACS) during transcatheter aortic valve implantation (TAVI)...
  7. Pees C, Michel Behnke I. Morphology of the bicuspid aortic valve and elasticity of the adjacent aorta in children. Am J Cardiol. 2012;110:1354-60 pubmed publisher
    Bicuspid aortic valve (BAV) is a common congenital malformation with the known sequela of ascending aortic dilation. The morphology of the BAV and the elasticity of the adjacent ascending aorta appear to influence the outcome...
  8. Kahlert P, Al Rashid F, Döttger P, Mori K, Plicht B, Wendt D, et al. Cerebral embolization during transcatheter aortic valve implantation: a transcranial Doppler study. Circulation. 2012;126:1245-55 pubmed publisher
    Transcatheter aortic valve implantation (TAVI) is associated with a higher risk of neurological events for both the transfemoral and transapical approach than surgical valve replacement...
  9. Yap C, Saikrishnan N, Tamilselvan G, Vasilyev N, Yoganathan A. The congenital bicuspid aortic valve can experience high-frequency unsteady shear stresses on its leaflet surface. Am J Physiol Heart Circ Physiol. 2012;303:H721-31 pubmed publisher
    The bicuspid aortic valve (BAV) is a common congenital malformation of the aortic valve (AV) affecting 1% to 2% of the population...
  10. Wang H, Haeger S, Kloxin A, Leinwand L, Anseth K. Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus. PLoS ONE. 2012;7:e39969 pubmed publisher
    ..These results provide insight in designing hydrogel substrates with physiologically relevant stiffness to dynamically redirect cell fate in vitro. ..
  11. Buellesfeld L, Stortecky S, Heg D, Hausen S, Mueller R, Wenaweser P, et al. Impact of permanent pacemaker implantation on clinical outcome among patients undergoing transcatheter aortic valve implantation. J Am Coll Cardiol. 2012;60:493-501 pubmed publisher
    ..pacemaker (PPM) implantation on clinical outcomes among patients undergoing transfemoral transcatheter aortic valve implantation (TAVI)...
  12. Bilen E, Akcay M, Bayram N, Koçak U, Kurt M, Tanboga I, et al. Aortic elastic properties and left ventricular diastolic function in patients with isolated bicuspid aortic valve. J Heart Valve Dis. 2012;21:189-94 pubmed
    Bicuspid aortic valve (BAV) is one of the most common congenital heart defects. BAV disease is not only a disorder of valvulogenesis, but also represents a genetic disorder of aorta and cardiac development...
  13. Dvir D, Barbash I, Ben dor I, Okubagzi P, Satler L, Waksman R, et al. The development of transcatheter aortic valve replacement in the USA. Arch Cardiovasc Dis. 2012;105:160-4 pubmed publisher
    The penetration rate of devices in general, and in transcatheter aortic valve replacement (TAVR) specifically, is significantly delayed in the United States of America (USA) compared with in Europe...
  14. Glauber M, Miceli A, Gilmanov D, Ferrarini M, Bevilacqua S, Farneti P, et al. Right anterior minithoracotomy versus conventional aortic valve replacement: a propensity score matched study. J Thorac Cardiovasc Surg. 2013;145:1222-6 pubmed publisher
    Minimally invasive aortic valve surgery by way of a right anterior minithoracotomy has shown excellent results in terms of mortality, morbidities, and patient satisfaction...
  15. Reinsfelt B, Westerlind A, Ioanes D, Zetterberg H, Fredén Lindqvist J, Ricksten S. Transcranial Doppler microembolic signals and serum marker evidence of brain injury during transcatheter aortic valve implantation. Acta Anaesthesiol Scand. 2012;56:240-7 pubmed publisher
    Recent studies have shown that transcatheter aortic valve implantation (TAVI) is associated with new foci of restricted diffusion on cerebral magnetic resonance imaging suggestive of cerebral microembolism...
  16. Nagy E, Andersson D, Caidahl K, Eriksson M, Eriksson P, Franco Cereceda A, et al. Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts. Circulation. 2011;123:1316-25 pubmed publisher
    The development of aortic valve stenosis is not only associated with calcification and extracellular matrix remodeling, but also with inflammation...
  17. Howell N, Ashrafian H, Drury N, Ranasinghe A, Contractor H, Isackson H, et al. Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) . Circulation. 2011;123:170-7 pubmed publisher
    Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy...