olfactory receptor neurons

Summary

Summary: Neurons in the OLFACTORY EPITHELIUM with proteins (RECEPTORS, ODORANT) that bind, and thus detect, odorants. These neurons send their DENDRITES to the surface of the epithelium with the odorant receptors residing in the apical non-motile cilia. Their unmyelinated AXONS synapse in the OLFACTORY BULB of the BRAIN.

Top Publications

  1. Watanabe H, Haupt S, Nishino H, Nishikawa M, Yokohari F. Sensillum-specific, topographic projection patterns of olfactory receptor neurons in the antennal lobe of the cockroach Periplaneta americana. J Comp Neurol. 2012;520:1687-701 pubmed publisher
    In vertebrates and many invertebrates, olfactory signals detected by peripheral olfactory receptor neurons (ORNs) are conveyed to a primary olfactory center with glomerular organization in which odor-specific activity patterns are ..
  2. Yaksi E, Wilson R. Electrical coupling between olfactory glomeruli. Neuron. 2010;67:1034-47 pubmed publisher
    ..We propose that when stimuli are weak, lateral excitation promotes sensitivity, whereas when stimuli are strong, lateral excitation helps recruit inhibitory gain control. ..
  3. Moberly A, Czarnecki L, Pottackal J, Rubinstein T, Turkel D, Kass M, et al. Intranasal exposure to manganese disrupts neurotransmitter release from glutamatergic synapses in the central nervous system in vivo. Neurotoxicology. 2012;33:996-1004 pubmed publisher
    ....
  4. Jaen C, Ozdener M, Reisert J. Mechanisms of chloride uptake in frog olfactory receptor neurons. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011;197:339-49 pubmed publisher
    Odorant stimulation of olfactory receptor neurons (ORNs) leads to the activation of a Ca(2+) permeable cyclic nucleotide-gated (CNG) channel followed by opening of an excitatory Ca(2+)-activated Cl(-) channel, which carries about 70% of ..
  5. Nakamuta S, Nakamuta N, Taniguchi K. Distinct axonal projections from two types of olfactory receptor neurons in the middle chamber epithelium of Xenopus laevis. Cell Tissue Res. 2011;346:27-33 pubmed publisher
    ..Thus, Xenopus laevis is a very interesting model to understand the evolution of vertebrate olfactory systems because they have a primitive, fish-type olfactory system in addition to the mammalian-type olfactory system. ..
  6. Zavada A, Buckley C, Martinez D, Rospars J, Nowotny T. Competition-based model of pheromone component ratio detection in the moth. PLoS ONE. 2011;6:e16308 pubmed publisher
    ..that (1) accuracy is mainly achieved by maintaining a certain ratio of connection strengths between olfactory receptor neurons (ORN) and local neurons (LN), much less by properties of the interconnections between the competing LNs ..
  7. Nakamuta S, Nakamuta N, Taniguchi K, Taniguchi K. Histological and ultrastructural characteristics of the primordial vomeronasal organ in lungfish. Anat Rec (Hoboken). 2012;295:481-91 pubmed publisher
    ..quot; This study may provide important clues to elucidate how the vomeronasal organ emerged during the evolution of vertebrates...
  8. Stephan A, Tobochnik S, Dibattista M, Wall C, Reisert J, Zhao H. The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response. Nat Neurosci. 2011;15:131-7 pubmed publisher
    ..These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception. ..
  9. German P, van der Poel S, Carraher C, Kralicek A, Newcomb R. Insights into subunit interactions within the insect olfactory receptor complex using FRET. Insect Biochem Mol Biol. 2013;43:138-45 pubmed publisher
    ..In summary, this study supports previously observed homomeric and heteromeric interactions between Orco and the ligand-binding OR, Or22a, and identifies a novel interaction between Or22a and SNMP1. ..
  10. Miyamichi K, Amat F, Moussavi F, Wang C, Wickersham I, Wall N, et al. Cortical representations of olfactory input by trans-synaptic tracing. Nature. 2011;472:191-6 pubmed publisher
    In the mouse, each class of olfactory receptor neurons expressing a given odorant receptor has convergent axonal projections to two specific glomeruli in the olfactory bulb, thereby creating an odour map...

Locale

Detail Information

Publications79

  1. Watanabe H, Haupt S, Nishino H, Nishikawa M, Yokohari F. Sensillum-specific, topographic projection patterns of olfactory receptor neurons in the antennal lobe of the cockroach Periplaneta americana. J Comp Neurol. 2012;520:1687-701 pubmed publisher
    In vertebrates and many invertebrates, olfactory signals detected by peripheral olfactory receptor neurons (ORNs) are conveyed to a primary olfactory center with glomerular organization in which odor-specific activity patterns are ..
  2. Yaksi E, Wilson R. Electrical coupling between olfactory glomeruli. Neuron. 2010;67:1034-47 pubmed publisher
    ..We propose that when stimuli are weak, lateral excitation promotes sensitivity, whereas when stimuli are strong, lateral excitation helps recruit inhibitory gain control. ..
  3. Moberly A, Czarnecki L, Pottackal J, Rubinstein T, Turkel D, Kass M, et al. Intranasal exposure to manganese disrupts neurotransmitter release from glutamatergic synapses in the central nervous system in vivo. Neurotoxicology. 2012;33:996-1004 pubmed publisher
    ....
  4. Jaen C, Ozdener M, Reisert J. Mechanisms of chloride uptake in frog olfactory receptor neurons. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011;197:339-49 pubmed publisher
    Odorant stimulation of olfactory receptor neurons (ORNs) leads to the activation of a Ca(2+) permeable cyclic nucleotide-gated (CNG) channel followed by opening of an excitatory Ca(2+)-activated Cl(-) channel, which carries about 70% of ..
  5. Nakamuta S, Nakamuta N, Taniguchi K. Distinct axonal projections from two types of olfactory receptor neurons in the middle chamber epithelium of Xenopus laevis. Cell Tissue Res. 2011;346:27-33 pubmed publisher
    ..Thus, Xenopus laevis is a very interesting model to understand the evolution of vertebrate olfactory systems because they have a primitive, fish-type olfactory system in addition to the mammalian-type olfactory system. ..
  6. Zavada A, Buckley C, Martinez D, Rospars J, Nowotny T. Competition-based model of pheromone component ratio detection in the moth. PLoS ONE. 2011;6:e16308 pubmed publisher
    ..that (1) accuracy is mainly achieved by maintaining a certain ratio of connection strengths between olfactory receptor neurons (ORN) and local neurons (LN), much less by properties of the interconnections between the competing LNs ..
  7. Nakamuta S, Nakamuta N, Taniguchi K, Taniguchi K. Histological and ultrastructural characteristics of the primordial vomeronasal organ in lungfish. Anat Rec (Hoboken). 2012;295:481-91 pubmed publisher
    ..quot; This study may provide important clues to elucidate how the vomeronasal organ emerged during the evolution of vertebrates...
  8. Stephan A, Tobochnik S, Dibattista M, Wall C, Reisert J, Zhao H. The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response. Nat Neurosci. 2011;15:131-7 pubmed publisher
    ..These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception. ..
  9. German P, van der Poel S, Carraher C, Kralicek A, Newcomb R. Insights into subunit interactions within the insect olfactory receptor complex using FRET. Insect Biochem Mol Biol. 2013;43:138-45 pubmed publisher
    ..In summary, this study supports previously observed homomeric and heteromeric interactions between Orco and the ligand-binding OR, Or22a, and identifies a novel interaction between Or22a and SNMP1. ..
  10. Miyamichi K, Amat F, Moussavi F, Wang C, Wickersham I, Wall N, et al. Cortical representations of olfactory input by trans-synaptic tracing. Nature. 2011;472:191-6 pubmed publisher
    In the mouse, each class of olfactory receptor neurons expressing a given odorant receptor has convergent axonal projections to two specific glomeruli in the olfactory bulb, thereby creating an odour map...
  11. Rodriguez Gil D, Treloar H, Zhang X, Miller A, Two A, Iwema C, et al. Chromosomal location-dependent nonstochastic onset of odor receptor expression. J Neurosci. 2010;30:10067-75 pubmed publisher
    ..Collectively, these studies demonstrate that ORs are not equally represented in the "olfactome" across an animal's lifespan. ..
  12. Sen S, Hartmann B, Reichert H, Rodrigues V. Expression and function of the empty spiracles gene in olfactory sense organ development of Drosophila melanogaster. Development. 2010;137:3687-95 pubmed publisher
    ....
  13. Nickell M, Breheny P, Stromberg A, McClintock T. Genomics of mature and immature olfactory sensory neurons. J Comp Neurol. 2012;520:2608-29 pubmed publisher
    ..This OSN gene database not only predicts the genes responsible for the major biological processes active in OSNs, but also identifies thousands of never before studied genes that support OSN phenotypes...
  14. O Halloran D, Hamilton O, LEE J, Gallegos M, L Etoile N. Changes in cGMP levels affect the localization of EGL-4 in AWC in Caenorhabditis elegans. PLoS ONE. 2012;7:e31614 pubmed publisher
    ....
  15. Ukhanov K, Brunert D, Corey E, Ache B. Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J Neurosci. 2011;31:273-80 pubmed publisher
    ..3-kinase (PI3K) signaling, has been implicated in mediating inhibitory odorant input to mammalian olfactory receptor neurons (ORNs)...
  16. Xie F, Fang C, Schnittke N, Schwob J, Ding X. Mechanisms of permanent loss of olfactory receptor neurons induced by the herbicide 2,6-dichlorobenzonitrile: effects on stem cells and noninvolvement of acute induction of the inflammatory cytokine IL-6. Toxicol Appl Pharmacol. 2013;272:598-607 pubmed publisher
    ....
  17. Kadala A, Charreton M, Jakob I, Le Conte Y, Collet C. A use-dependent sodium current modification induced by type I pyrethroid insecticides in honeybee antennal olfactory receptor neurons. Neurotoxicology. 2011;32:320-30 pubmed publisher
    We studied the mode of action of type I pyrethroids on the voltage-dependent sodium current from honeybee olfactory receptor neurons (ORNs), whose proper function in antenna is crucial for interindividual communication in this species...
  18. Martin F, Riveron J, Alcorta E. Environmental temperature modulates olfactory reception in Drosophila melanogaster. J Insect Physiol. 2011;57:1631-42 pubmed publisher
    ..However, the number and shape of spontaneous action potentials were unaffected, suggesting that the observed changes related specifically to the olfactory function of the neurons...
  19. Khan M, Vaes E, Mombaerts P. Regulation of the probability of mouse odorant receptor gene choice. Cell. 2011;147:907-21 pubmed publisher
    ..Thus, the P and H elements regulate the probability of OR gene choice, not OR transcript level per OSN...
  20. Hao S, Yu F, Yan A, Zhang Y, Han J, Jiang X. In utero and lactational lanthanum exposure induces olfactory dysfunction associated with downregulation of βIII-tubulin and olfactory marker protein in young rats. Biol Trace Elem Res. 2012;148:383-91 pubmed publisher
    ..Developmental lanthanum exposure could impair olfaction, and this deficit may be attributed to the downregulation of βIII-tubulin and OMP in the OE...
  21. Rowe T, Macrini T, Luo Z. Fossil evidence on origin of the mammalian brain. Science. 2011;332:955-7 pubmed publisher
    ..The origin of crown Mammalia saw a third pulse of olfactory enhancement, with ossified ethmoid turbinals supporting an expansive olfactory epithelium in the nasal cavity, allowing full expression of a huge odorant receptor genome...
  22. Abuin L, Bargeton B, Ulbrich M, Isacoff E, Kellenberger S, Benton R. Functional architecture of olfactory ionotropic glutamate receptors. Neuron. 2011;69:44-60 pubmed publisher
    ..Our results provide insights into the conserved and distinct architecture of these olfactory and synaptic ion channels and offer perspectives into the use of IRs as genetically encoded chemical sensors...
  23. Zhang J, Pacifico R, Cawley D, Feinstein P, Bozza T. Ultrasensitive detection of amines by a trace amine-associated receptor. J Neurosci. 2013;33:3228-39 pubmed publisher
    ..The data suggest that the TAARs are evolutionarily retained in the olfactory receptor repertoire to mediate high-sensitivity detection of a biologically relevant class of odorous stimuli...
  24. Münch D, Schmeichel B, Silbering A, Galizia C. Weaker ligands can dominate an odor blend due to syntopic interactions. Chem Senses. 2013;38:293-304 pubmed publisher
    ..Our data have important implications for how odor mixtures are processed in general, and what preprocessing occurs before the information reaches the brain...
  25. Carlsson M, Diesner M, Schachtner J, Nassel D. Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits. J Comp Neurol. 2010;518:3359-80 pubmed publisher
    ..In some neuron types neuropeptides were colocalized with classical neurotransmitters. Our findings suggest a huge complexity in peptidergic signaling in different circuits of the antennal lobe...
  26. Zhou Y, Wilson R. Transduction in Drosophila olfactory receptor neurons is invariant to air speed. J Neurophysiol. 2012;108:2051-9 pubmed publisher
    In the vertebrate nose, increasing air speed tends to increase the magnitude of odor-evoked activity in olfactory receptor neurons (ORNs), given constant odor concentration and duration...
  27. Jarriault D, Gadenne C, Lucas P, Rospars J, Anton S. Transformation of the sex pheromone signal in the noctuid moth Agrotis ipsilon: from peripheral input to antennal lobe output. Chem Senses. 2010;35:705-15 pubmed publisher
    ..mechanisms at different levels of the olfactory pathway, we performed single-cell recordings of olfactory receptor neurons (ORNs) in the antenna and intracellular recordings of central neurons in the macroglomerular complex (..
  28. Larkin A, Karak S, Priya R, Das A, Ayyub C, Ito K, et al. Central synaptic mechanisms underlie short-term olfactory habituation in Drosophila larvae. Learn Mem. 2010;17:645-53 pubmed publisher
    ..Our observations suggest a model in which NMDAR-dependent depression of the OSN-PN synapse and/or NMDAR-dependent facilitation of inhibitory transmission from LNs to PNs contributes substantially to short-term habituation...
  29. Bachtiar L, Unsworth C, Newcomb R, Crampin E. Using artificial neural networks to classify unknown volatile chemicals from the firings of insect olfactory sensory neurons. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2752-5 pubmed publisher
    ..This demonstrates that a 10% noise injected series of MLPs provides a robust method for classifying chemicals from the firing rates of OSNs and paves the way to a future realisation of an artificial olfactory biosensor...
  30. Hillier N, Vickers N. Mixture interactions in moth olfactory physiology: examining the effects of odorant mixture, concentration, distal stimulation, and antennal nerve transection on sensillar responses. Chem Senses. 2011;36:93-108 pubmed publisher
    ..virescens ORNs...
  31. Nagel K, Wilson R. Biophysical mechanisms underlying olfactory receptor neuron dynamics. Nat Neurosci. 2011;14:208-16 pubmed publisher
    The responses of olfactory receptor neurons (ORNs) to odors have complex dynamics...
  32. Luo S, Axel R, Abbott L. Generating sparse and selective third-order responses in the olfactory system of the fly. Proc Natl Acad Sci U S A. 2010;107:10713-8 pubmed publisher
    In the antennal lobe of Drosophila, information about odors is transferred from olfactory receptor neurons (ORNs) to projection neurons (PNs), which then send axons to neurons in the lateral horn of the protocerebrum (LHNs) and to Kenyon ..
  33. Party V, Hanot C, Büsser D, Rochat D, Renou M. Changes in odor background affect the locomotory response to pheromone in moths. PLoS ONE. 2013;8:e52897 pubmed publisher
    ..locomotion was correlated with the capacity of the plant compound to antagonize pheromone detection by olfactory receptor neurons, suggesting a masking effect of the background over the pheromone signal...
  34. Schendzielorz T, Peters W, Boekhoff I, Stengl M. Time of day changes in cyclic nucleotides are modified via octopamine and pheromone in antennae of the Madeira cockroach. J Biol Rhythms. 2012;27:388-97 pubmed
    ..In moths' olfactory receptor neurons, adapting pheromone concentrations elevate cGMP levels, which decrease pheromone sensitivity...
  35. Munger S, Leinders Zufall T, McDougall L, Cockerham R, Schmid A, Wandernoth P, et al. An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr Biol. 2010;20:1438-44 pubmed publisher
    ..Our findings indicate that GC-D(+) OSNs detect chemosignals that facilitate food-related social interactions...
  36. Rouyar A, Party V, Presern J, Blejec A, Renou M. A general odorant background affects the coding of pheromone stimulus intermittency in specialist olfactory receptor neurones. PLoS ONE. 2011;6:e26443 pubmed publisher
    ..background odor on behavior and coding of temporal parameters of pheromone pulse trains in the pheromone olfactory receptor neurons of Spodoptera littoralis...
  37. Oztokatli H, Hörnberg M, Berghard A, Bohm S. Retinoic acid receptor and CNGA2 channel signaling are part of a regulatory feedback loop controlling axonal convergence and survival of olfactory sensory neurons. FASEB J. 2012;26:617-27 pubmed publisher
    ..Combined, these results identify a novel homeostatic feedback mechanism involving retinoic acid metabolism and CNG channel activity, which influences glomerular homogeneity and maintenance of precisely connected OSNs...
  38. Cui X, Wu C, Zhang L. Electrophysiological response patterns of 16 olfactory neurons from the trichoid sensilla to odorant from fecal volatiles in the locust, locusta migratoria manilensis. Arch Insect Biochem Physiol. 2011;77:45-57 pubmed publisher
    ..locate their host plants primarily through olfactory cues, using antennal chemosensilla, which house olfactory receptor neurons (ORNs)...
  39. Su C, Martelli C, Emonet T, Carlson J. Temporal coding of odor mixtures in an olfactory receptor neuron. Proc Natl Acad Sci U S A. 2011;108:5075-80 pubmed publisher
    ..Here we show that sophisticated integration of olfactory information begins in olfactory receptor neurons (ORNs) in Drosophila...
  40. Castiglioni A, REMIS N, Flores E, Garcia Anoveros J. Expression and vesicular localization of mouse Trpml3 in stria vascularis, hair cells, and vomeronasal and olfactory receptor neurons. J Comp Neurol. 2011;519:1095-1114 pubmed publisher
    ..Finally, we found that vomeronasal and olfactory sensory receptor cells do express TRPML3 mRNA and protein, which localizes to vesicles in their somas and dendrites as well as at apical dendritic knobs...
  41. Ukhanov K, Bobkov Y, Ache B. Imaging ensemble activity in arthropod olfactory receptor neurons in situ. Cell Calcium. 2011;49:100-7 pubmed publisher
    We show that lobster olfactory receptor neurons (ORNs), much like their vertebrate counterparts, generate a transient elevation of intracellular calcium (Ca(i)) in response to odorant activation that can be used to monitor ensemble ORN ..
  42. Hu A, Zhang W, Wang Z. Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway. Proc Natl Acad Sci U S A. 2010;107:10262-7 pubmed publisher
    ..The presence of this functional feedback from the mushroom bodies to the antennal lobes suggests top-down modulation of olfactory information processing in Drosophila...
  43. Jones P, Pask G, Romaine I, Taylor R, Reid P, Waterson A, et al. Allosteric antagonism of insect odorant receptor ion channels. PLoS ONE. 2012;7:e30304 pubmed publisher
    ..Orco functions as a non-selective cation channel and is expressed in the majority of olfactory receptor neurons (ORNs)...
  44. Baker T, Domingue M, Myrick A. Working range of stimulus flux transduction determines dendrite size and relative number of pheromone component receptor neurons in moths. Chem Senses. 2012;37:299-313 pubmed publisher
    ..that the "relative" abundances of the differently tuned pheromone-component-responsive olfactory receptor neurons (ORNs) on insect antennae are not a result of natural selection working to maximize absolute sensitivity ..
  45. Durand N, Carot Sans G, Chertemps T, Bozzolan F, Party V, Renou M, et al. Characterization of an antennal carboxylesterase from the pest moth Spodoptera littoralis degrading a host plant odorant. PLoS ONE. 2010;5:e15026 pubmed publisher
    ..These enzymes are only expressed in the male antennae, and secreted into the lumen of the pheromone-sensitive sensilla. CCEs able to hydrolyze other odorants than sex pheromones, such as plant volatiles, have not been identified...
  46. Thompson J, Salcedo E, Restrepo D, Finger T. Second-order input to the medial amygdala from olfactory sensory neurons expressing the transduction channel TRPM5. J Comp Neurol. 2012;520:1819-30 pubmed publisher
    ....
  47. Ghosh S, Larson S, Hefzi H, Marnoy Z, Cutforth T, Dokka K, et al. Sensory maps in the olfactory cortex defined by long-range viral tracing of single neurons. Nature. 2011;472:217-20 pubmed publisher
    ....
  48. Thiebaud N, Menetrier F, Belloir C, Minn A, Neiers F, Artur Y, et al. Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium. Neurosci Lett. 2011;505:180-5 pubmed publisher
    ..The pattern of expression and the distinct localization of the olfactory transporters showed in this work may highlight on their specific function in the whole olfactory epithelium...
  49. Hubbard P, Barata E, Ozorio R, Valente L, Canario A. Olfactory sensitivity to amino acids in the blackspot sea bream (Pagellus bogaraveo): a comparison between olfactory receptor recording techniques in seawater. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011;197:839-49 pubmed publisher
    ....
  50. Bhandawat V, Maimon G, Dickinson M, Wilson R. Olfactory modulation of flight in Drosophila is sensitive, selective and rapid. J Exp Biol. 2010;213:3625-35 pubmed publisher
    ..First, we verified that these behaviors are abolished by mutations that silence olfactory receptor neurons (ORNs)...
  51. Reisert J. Origin of basal activity in mammalian olfactory receptor neurons. J Gen Physiol. 2010;136:529-40 pubmed publisher
    ..diverse group of G protein-coupled receptors that determine the sensitivity and response profile of olfactory receptor neurons. But little is known if odorant receptors control basal and also stimulus-induced cellular properties of ..
  52. Stakic J, Suchanek J, Ziegler G, Griff E. The source of spontaneous activity in the main olfactory bulb of the rat. PLoS ONE. 2011;6:e23990 pubmed publisher
    ..This paper tests the hypothesis that spontaneous activity in olfactory receptor neurons drives much of the spontaneous activity in mitral and tufted cells via excitatory synapses.
  53. Wang J. Presynaptic modulation of early olfactory processing in Drosophila. Dev Neurobiol. 2012;72:87-99 pubmed publisher
    ..This review will focus on the GABA(B) (gamma-aminobutyric acid) receptor-mediated presynaptic inhibition, and neuropeptide-mediated presynaptic modulation in Drosophila...
  54. Ferrero D, Lemon J, Fluegge D, Pashkovski S, Korzan W, Datta S, et al. Detection and avoidance of a carnivore odor by prey. Proc Natl Acad Sci U S A. 2011;108:11235-40 pubmed publisher
    ..These data show how a single, volatile chemical detected in the environment can drive an elaborate danger-associated behavioral response in mammals...
  55. Nara K, Saraiva L, Ye X, Buck L. A large-scale analysis of odor coding in the olfactory epithelium. J Neurosci. 2011;31:9179-91 pubmed publisher
    ....
  56. Knaden M, Strutz A, Ahsan J, Sachse S, Hansson B. Spatial representation of odorant valence in an insect brain. Cell Rep. 2012;1:392-9 pubmed publisher
    ..The basal anatomical structure of the olfactory circuit between insects and vertebrates is known to be similar; our study suggests that the representation of odorant valence is as well...
  57. Pacifico R, Dewan A, Cawley D, Guo C, Bozza T. An olfactory subsystem that mediates high-sensitivity detection of volatile amines. Cell Rep. 2012;2:76-88 pubmed publisher
    ..Our data uncover a hard-wired, parallel input stream in the main olfactory pathway that is specialized for the detection of volatile amines...
  58. DeMaria S, Ngai J. The cell biology of smell. J Cell Biol. 2010;191:443-52 pubmed publisher
    ..This review will focus on the diverse roles of the odorant receptor in the function and development of the olfactory system...
  59. Cavallin M, Powell K, Biju K, Fadool D. State-dependent sculpting of olfactory sensory neurons is attributed to sensory enrichment, odor deprivation, and aging. Neurosci Lett. 2010;483:90-5 pubmed publisher
    ..These findings suggest that voltage-gated activity of the mitral cells is important for OSN plasticity, and can prevent neuronal loss via sensory- and OR-dependent mechanisms...
  60. Chaput M, El Mountassir F, Atanasova B, Thomas Danguin T, Le Bon A, Perrut A, et al. Interactions of odorants with olfactory receptors and receptor neurons match the perceptual dynamics observed for woody and fruity odorant mixtures. Eur J Neurosci. 2012;35:584-97 pubmed publisher
    ..transfected with olfactory receptors (ORs); (ii) single-unit electrophysiological recordings from olfactory receptor neurons (ORNs) and analyses of electro-olfactogram (EOG) responses in the rat nose in vivo; and (iii) ..
  61. Lee A, He J, Ma M. Olfactory marker protein is critical for functional maturation of olfactory sensory neurons and development of mother preference. J Neurosci. 2011;31:2974-82 pubmed publisher
    ..These results reveal that OSNs undergo an OMP-dependent functional maturation process that coincides with early development of the smell function, which is essential for pups to form preference for their mother...
  62. Ikeda K, Kageyama R, Suzuki Y, Kawakami K. Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. Int J Dev Biol. 2010;54:1453-64 pubmed publisher
    ..In established neurogenesis, which starts at embryonic day (E) 12.5, sustentacular cells and olfactory receptor neurons (ORNs) are produced from apical and basal progenitors, respectively...
  63. Sweeney L, Chou Y, Wu Z, Joo W, Komiyama T, Potter C, et al. Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Neuron. 2011;72:734-47 pubmed publisher
    ..the developing antennal lobe before the arrival of axons from their presynaptic partners, the adult olfactory receptor neurons (ORNs)...
  64. Pifferi S, Cenedese V, Menini A. Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction. Exp Physiol. 2012;97:193-9 pubmed publisher
    ..Finally, we discuss the involvement of Ca(2+)-activated Cl(-) channels in the transduction process of vomeronasal sensory neurons and the physiological role of these channels in olfaction...
  65. Belmabrouk H, Nowotny T, Rospars J, Martinez D. Interaction of cellular and network mechanisms for efficient pheromone coding in moths. Proc Natl Acad Sci U S A. 2011;108:19790-5 pubmed publisher
    ..The first inhibition plays the role of a reset to limit variability in the time to first spike. The second inhibition prevents responses of excessive duration to allow tracking of intermittent stimuli...
  66. Bhandawat V, Reisert J, Yau K. Signaling by olfactory receptor neurons near threshold. Proc Natl Acad Sci U S A. 2010;107:18682-7 pubmed publisher
    ..2 pA. Thus, it takes about 35 odorant-binding events successfully triggering transduction during a brief odorant pulse in order for an ORN to signal to the brain...
  67. Silbering A, Rytz R, Grosjean Y, Abuin L, Ramdya P, Jefferis G, et al. Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystems. J Neurosci. 2011;31:13357-75 pubmed publisher
    ..We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems...
  68. Bazáes A, Olivares J, Schmachtenberg O. Properties, projections, and tuning of teleost olfactory receptor neurons. J Chem Ecol. 2013;39:451-64 pubmed publisher
    ..on the molecular properties, functions, and associated neural pathways of the three types of teleost olfactory receptor neurons with special emphasis on the crypt cell, and evaluate their roles in the detection of food, social and ..
  69. French A, Torkkeli P, Schuckel J. Dynamic characterization of Drosophila antennal olfactory neurons indicates multiple opponent signaling pathways in odor discrimination. J Neurosci. 2011;31:861-9 pubmed publisher
    ..Each odorant caused opposing excitatory and inhibitory signals to be sent to the antennal lobe along at least two pairs of axonal pathways...
  70. Ben Chaim Y, Cheng M, Yau K. Unitary response of mouse olfactory receptor neurons. Proc Natl Acad Sci U S A. 2011;108:822-7 pubmed publisher
    The sense of smell begins with odorant molecules binding to membrane receptors on the cilia of olfactory receptor neurons (ORNs), thereby activating a G protein, G(olf), and the downstream effector enzyme, an adenylyl cyclase (ACIII)...
  71. Brochtrup A, Hummel T. Olfactory map formation in the Drosophila brain: genetic specificity and neuronal variability. Curr Opin Neurobiol. 2011;21:85-92 pubmed publisher
    ..Recent findings revealed an astonishing morphological diversity among members of the same interneuron class, suggesting an unexpected variability in local microcircuits involved in insect sensory processing...
  72. Bohbot J, Dickens J. Insect repellents: modulators of mosquito odorant receptor activity. PLoS ONE. 2010;5:e12138 pubmed publisher
    ....
  73. Sakano H. Neural map formation in the mouse olfactory system. Neuron. 2010;67:530-42 pubmed publisher
    ..Here, we review the recent progress on the study of olfactory map formation in rodents. We will discuss how neuronal identity is represented at axon termini and how the OR-instructed axonal projection is regulated...
  74. Chou Y, Zheng X, Beachy P, Luo L. Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. Cell. 2010;142:954-66 pubmed publisher
    ..evidence for a coupled two-step action of Hedgehog signaling in patterning axon targeting of Drosophila olfactory receptor neurons (ORNs)...
  75. Barrozo R, Jarriault D, Deisig N, Gemeno C, Monsempes C, Lucas P, et al. Mating-induced differential coding of plant odour and sex pheromone in a male moth. Eur J Neurosci. 2011;33:1841-50 pubmed publisher
    ....
  76. Billig G, Pál B, Fidzinski P, Jentsch T. Ca2+-activated Cl− currents are dispensable for olfaction. Nat Neurosci. 2011;14:763-9 pubmed publisher
    ..We identified Anoctamin2 (Ano2, also known as TMEM16B) as the ciliary Ca(2+)-activated Cl(-) channel of olfactory receptor neurons. Ano2 is expressed in the main olfactory epithelium (MOE) and in the vomeronasal organ (VNO), which also ..
  77. Grosjean Y, Rytz R, Farine J, Abuin L, Cortot J, Jefferis G, et al. An olfactory receptor for food-derived odours promotes male courtship in Drosophila. Nature. 2011;478:236-40 pubmed publisher
    ..These findings reveal an unusual but effective evolutionary solution to coordinate feeding and oviposition site selection with reproductive behaviours through a specific sensory pathway...
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    ..We propose that this perspective is beneficial for insect olfactory neurobiology in particular and sensory neurobiology in general...