16 dimethylprostaglandin e2 16

Summary

Summary: A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors.

Top Publications

  1. Nonoyama K, Nakagawa K, Amagase K, Takeuchi K, Nakamura M, Okabe S. New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin. J Gastroenterol Hepatol. 2010;25 Suppl 1:S15-22 pubmed publisher
    ..This new aspirin lesion model will be useful for screening defensive drugs against aspirin-induced intestinal lesions and to elucidate the underlying mechanism. ..
  2. Failla M, Genovese T, Mazzon E, Fruciano M, Fagone E, Gili E, et al. 16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis. Am J Respir Cell Mol Biol. 2009;41:50-8 pubmed publisher
  3. Sjöblom M, Singh A, Zheng W, Wang J, Tuo B, Krabbenhöft A, et al. Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci U S A. 2009;106:13094-9 pubmed publisher
    ..The results suggest that CA II is important for duodenocyte acidification by low luminal pH and for eliciting the acid-mediated HCO(3)(-) secretory response, but is not important in the generation of the secreted HCO(3)(-) ions. ..
  4. Peskar B, Ehrlich K, Schuligoi R, Peskar B. Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats. Pharmacology. 2009;84:294-9 pubmed publisher
    ..The results suggest that not only cyclooxygenases, but also lipoxygenases have a role in limiting gastric mucosal damage during ischemia-reperfusion. ..
  5. Amagase K, Ochi A, Sugihara T, Kato S, Takeuchi K. Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats. J Gastroenterol Hepatol. 2010;25 Suppl 1:S111-8 pubmed publisher
  6. Takeuchi K, Tanigami M, Amagase K, Ochi A, Okuda S, Hatazawa R. Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors. J Gastroenterol Hepatol. 2010;25 Suppl 1:S67-74 pubmed publisher
    ..The results suggest that endogenous PGE(2) promotes the healing of small intestinal lesions by stimulating angiogenesis through the upregulation of VEGF expression mediated by the activation of EP4 receptors. ..
  7. Ma W. Chronic prostaglandin E2 treatment induces the synthesis of the pain-related peptide substance P and calcitonin gene-related peptide in cultured sensory ganglion explants. J Neurochem. 2010;115:363-72 pubmed publisher
    ..We thus conclude that facilitating the synthesis of pain-related peptides in nociceptors is a novel mechanism underlying the role of PGE2 in nociception and chronic pain states. ..

Detail Information

Publications7

  1. Nonoyama K, Nakagawa K, Amagase K, Takeuchi K, Nakamura M, Okabe S. New method of inducing intestinal lesions in rats by intraduodenal administration of aspirin. J Gastroenterol Hepatol. 2010;25 Suppl 1:S15-22 pubmed publisher
    ..This new aspirin lesion model will be useful for screening defensive drugs against aspirin-induced intestinal lesions and to elucidate the underlying mechanism. ..
  2. Failla M, Genovese T, Mazzon E, Fruciano M, Fagone E, Gili E, et al. 16,16-Dimethyl prostaglandin E2 efficacy on prevention and protection from bleomycin-induced lung injury and fibrosis. Am J Respir Cell Mol Biol. 2009;41:50-8 pubmed publisher
  3. Sjöblom M, Singh A, Zheng W, Wang J, Tuo B, Krabbenhöft A, et al. Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci U S A. 2009;106:13094-9 pubmed publisher
    ..The results suggest that CA II is important for duodenocyte acidification by low luminal pH and for eliciting the acid-mediated HCO(3)(-) secretory response, but is not important in the generation of the secreted HCO(3)(-) ions. ..
  4. Peskar B, Ehrlich K, Schuligoi R, Peskar B. Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats. Pharmacology. 2009;84:294-9 pubmed publisher
    ..The results suggest that not only cyclooxygenases, but also lipoxygenases have a role in limiting gastric mucosal damage during ischemia-reperfusion. ..
  5. Amagase K, Ochi A, Sugihara T, Kato S, Takeuchi K. Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats. J Gastroenterol Hepatol. 2010;25 Suppl 1:S111-8 pubmed publisher
  6. Takeuchi K, Tanigami M, Amagase K, Ochi A, Okuda S, Hatazawa R. Endogenous prostaglandin E2 accelerates healing of indomethacin-induced small intestinal lesions through upregulation of vascular endothelial growth factor expression by activation of EP4 receptors. J Gastroenterol Hepatol. 2010;25 Suppl 1:S67-74 pubmed publisher
    ..The results suggest that endogenous PGE(2) promotes the healing of small intestinal lesions by stimulating angiogenesis through the upregulation of VEGF expression mediated by the activation of EP4 receptors. ..
  7. Ma W. Chronic prostaglandin E2 treatment induces the synthesis of the pain-related peptide substance P and calcitonin gene-related peptide in cultured sensory ganglion explants. J Neurochem. 2010;115:363-72 pubmed publisher
    ..We thus conclude that facilitating the synthesis of pain-related peptides in nociceptors is a novel mechanism underlying the role of PGE2 in nociception and chronic pain states. ..