cd98 antigens

Summary

Summary: A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.

Top Publications

  1. ncbi Isolation and characterization of monoclonal antibodies directed against murine FRP-1/CD98/4F2 heavy chain: murine FRP-1 is an alloantigen and amino acid change at 129 (P<-->R) is related to the alloantigenicity
    H Tsumura
    Department of Microbiology, Mie University School of Medicine, Mie Ken, Japan
    Immunol Cell Biol 77:19-27. 1999
  2. ncbi CD98-mediated links between amino acid transport and beta 1 integrin distribution in polarized columnar epithelia
    D Merlin
    Epithelial Pathology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:39282-9. 2001
  3. ncbi Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules
    S Ohgimoto
    Department of Microbiology, Mie University School of Medicine, Japan
    J Immunol 155:3585-92. 1995
  4. ncbi Distinct domains of CD98hc regulate integrins and amino acid transport
    C A Fenczik
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:8746-52. 2001
  5. ncbi Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation
    Torsten Kucharzik
    Department of Medicine B, Münster University of Münster, Germany
    Lab Invest 85:932-41. 2005
  6. ncbi 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer
    E Nakamura
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 274:3009-16. 1999
  7. ncbi The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation
    J Y Cho
    Department of Immunology, Windeyer Institute of Medical Sciences, University College London, England
    Blood 98:374-82. 2001
  8. ncbi Characterization of the human intestinal CD98 promoter and its regulation by interferon-gamma
    Yutao Yan
    Div of Digestive Diseases, Dept of Medicine, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 292:G535-45. 2007
  9. ncbi CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia
    Xia Liu
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:23672-7. 2003
  10. ncbi CD98 modulates integrin beta1 function in polarized epithelial cells
    Songmin Cai
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    J Cell Sci 118:889-99. 2005

Research Grants

  1. CD98 (4F2 antigen) and Integrin Signaling in Vascular Smooth Muscle Cells.
    Dong Yun Lee; Fiscal Year: 2009
  2. HPEPT1 IN INTESTINAL INFLAMMATION
    Didier Merlin; Fiscal Year: 2003
  3. HPEPT1 IN INTESTINAL INFLAMMATION
    Didier Merlin; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi Isolation and characterization of monoclonal antibodies directed against murine FRP-1/CD98/4F2 heavy chain: murine FRP-1 is an alloantigen and amino acid change at 129 (P<-->R) is related to the alloantigenicity
    H Tsumura
    Department of Microbiology, Mie University School of Medicine, Mie Ken, Japan
    Immunol Cell Biol 77:19-27. 1999
    ....
  2. ncbi CD98-mediated links between amino acid transport and beta 1 integrin distribution in polarized columnar epithelia
    D Merlin
    Epithelial Pathology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:39282-9. 2001
    ..Furthermore, such findings suggest a link between classic transport events and a critical element of barrier function: integrin-mediated influences on cytoskeletal organization...
  3. ncbi Molecular characterization of fusion regulatory protein-1 (FRP-1) that induces multinucleated giant cell formation of monocytes and HIV gp160-mediated cell fusion. FRP-1 and 4F2/CD98 are identical molecules
    S Ohgimoto
    Department of Microbiology, Mie University School of Medicine, Japan
    J Immunol 155:3585-92. 1995
    ....
  4. ncbi Distinct domains of CD98hc regulate integrins and amino acid transport
    C A Fenczik
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 276:8746-52. 2001
    ..Furthermore, a mutant of CD98hc that lacks its integrin binding site can still promote increased isoleucine transport. Thus, these two functions of CD98hc are separable and require distinct domains of the protein...
  5. ncbi Activation of epithelial CD98 glycoprotein perpetuates colonic inflammation
    Torsten Kucharzik
    Department of Medicine B, Münster University of Münster, Germany
    Lab Invest 85:932-41. 2005
    ..Overall, our data suggest that epithelial CD98 plays an important role in the perpetuation of intestinal inflammation...
  6. ncbi 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer
    E Nakamura
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 274:3009-16. 1999
    ..The results predict the presence of multiple 4F2 light chains...
  7. ncbi The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 homotypic aggregation
    J Y Cho
    Department of Immunology, Windeyer Institute of Medical Sciences, University College London, England
    Blood 98:374-82. 2001
    ..The results of this study support a central role for CD98 within a multimolecular unit that regulates cell aggregation...
  8. ncbi Characterization of the human intestinal CD98 promoter and its regulation by interferon-gamma
    Yutao Yan
    Div of Digestive Diseases, Dept of Medicine, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 292:G535-45. 2007
    ....
  9. ncbi CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia
    Xia Liu
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:23672-7. 2003
    ..Our data provide a novel mechanism by which events such as adhesion may be integrated by amino acid transport activity resulting from the direct interaction of cell surface molecules such as CD98 and ICAM-1...
  10. ncbi CD98 modulates integrin beta1 function in polarized epithelial cells
    Songmin Cai
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    J Cell Sci 118:889-99. 2005
    ....
  11. ncbi Extracellular interaction between hCD98 and the PDZ class II domain of hCASK in intestinal epithelia
    Yutao Yan
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    J Membr Biol 215:15-26. 2007
    ..These novel results, which provide the first evidence for a PDZ domain-dependent interaction between a membrane protein and an extracellular protein, open a new field of investigation related to extracellular signaling in cell biology...
  12. ncbi Thyroid hormone transport by the heterodimeric human system L amino acid transporter
    E C Friesema
    Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    Endocrinology 142:4339-48. 2001
    ..Our results demonstrate stereospecific Na(+)-independent transport of iodothyronines by the human heterodimeric system L amino acid transporter...
  13. ncbi CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases
    Jae Youl Cho
    Department of Immunology and Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1T 6JF, UK
    Exp Cell Res 286:1-11. 2003
    ..One of the targets of CD98-induced tyrosine phosphorylation is itself PKCdelta, suggesting that this phosphorylation may act as a negative feedback to limit the overall activation of the CD98 pathway...
  14. ncbi CD98: a type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells
    A P Warren
    Department of Immunology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Blood 87:3676-87. 1996
    ..We suggest that CD98 is a cell membrane receptor involved in the control of cell survival/death of hematopoietic cells...
  15. ncbi Protein tyrosine kinase activation provides an early and obligatory signal in anti-FRP-1/CD98/4F2 monoclonal antibody induced cell fusion mediated by HIV gp160
    N Tabata
    Department of Microbiology, Mie University School of Medicine, Japan
    Med Microbiol Immunol 186:115-23. 1997
    ..Thus, our study may present evidence for a novel pathway of protein tyrosine kinases that phosphorylate specific, still unknown protein substrates during polykaryocyte formation...
  16. ncbi Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family
    L Mastroberardino
    Institute of Physiology, University of Zurich, Switzerland
    Nature 395:288-91. 1998
    ..The coexpression of h4F2hc is required for surface expression of these permease-related light chains, which belong to a new family of amino-acid transporters that form heterodimers with cell-surface glycoproteins...
  17. ncbi Integrins take partners: cross-talk between integrins and other membrane receptors
    J C Porter
    Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, UK
    Trends Cell Biol 8:390-6. 1998
    ..Here, Joanna Porter and Nancy Hogg discuss a few of the best characterized of these specialist integrin partnerships...
  18. ncbi Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance
    D Torrents
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain
    J Biol Chem 273:32437-45. 1998
    ..The pattern of expression of human y+LAT-1, its co-expressed transport activity with 4F2hc, and its chromosomal location within the LPI locus, suggest y+LAT-1 as a candidate gene for LPI...
  19. pmc Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family
    R Pfeiffer
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    EMBO J 18:49-57. 1999
    ....
  20. ncbi Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function
    P D Prasad
    Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta 30912, USA
    Biochem Biophys Res Commun 255:283-8. 1999
    ..It recognizes exclusively neutral amino acids with high affinity. LAT1-specific mRNA is expressed in most human tissues with the notable exception of the intestine...
  21. pmc Heterodimeric amino acid transporters: expression of heavy but not light chains of CD98 correlates with induction of amino acid transport systems in human placental trophoblast
    Y Kudo
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    J Physiol 523:13-8. 2000
    ....
  22. pmc Sequence-specific interaction between the disintegrin domain of mouse ADAM 3 and murine eggs: role of beta1 integrin-associated proteins CD9, CD81, and CD98
    Y Takahashi
    Department of Cell Biology, University of Virginia Health System, School of Medicine, Charlottesville, Virginia 22908, USA
    Mol Biol Cell 12:809-20. 2001
    ..We propose that an egg surface "tetraspan web" facilitates fertilization and that it may do so by fostering ADAM-integrin interactions...
  23. ncbi Sequential amino acid exchange across b(0,+)-like system in chicken brush border jejunum
    M Torras-Llort
    , , Universitat de Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain
    J Membr Biol 180:213-20. 2001
    ..A model of double translocation pathways with alternating access is discussed...
  24. pmc Cross-linking CD98 promotes integrin-like signaling and anchorage-independent growth
    Robert C Rintoul
    Lung Inflammation Group, Centre for Inflammation Research, University of Edinburgh, United Kingdom
    Mol Biol Cell 13:2841-52. 2002
    ..Activation of PI 3-kinase may, in part, explain cellular transformation seen on overexpressing CD98. These results may provide a paradigm for events involved in such diverse processes as inflammation and viral-induced cell fusion...
  25. ncbi Regulation of CD43-induced U937 homotypic aggregation
    Jae Youl Cho
    Department of Immunology of Molecular Pathology, Windeyer Institute of Medical Sciences, University College London, 46 Cleveland Street, London W1T 6JF, UK
    Exp Cell Res 290:155-67. 2003
    ..These mechanisms add a further dimension to the potential role of CD43 in tissue immune responses...
  26. ncbi Cynaropicrin, a sesquiterpene lactone, as a new strong regulator of CD29 and CD98 functions
    Jae Youl Cho
    School of Biotechnology and Bioengineering, Kangwon National University, Chuncheon 200 701, Republic of Korea
    Biochem Biophys Res Commun 313:954-61. 2004
    ....
  27. ncbi Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract
    Kuniaki Nakanishi
    Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, 359 8513, Japan
    Virchows Arch 451:681-90. 2007
    ..In conclusion, the detection of the active form of LAT1 protein would appear to be of value in informing the risk of progression in transitional cell carcinoma of the upper urinary tract...
  28. ncbi Cyclophilin B induces integrin-mediated cell adhesion by a mechanism involving CD98-dependent activation of protein kinase C-delta and p44/42 mitogen-activated protein kinases
    Aurélie Melchior
    Unite de Glycobiologie Structurale et Fonctionnelle, Unité Mixte de Recherche No 8576 du CNRS, Institut de Recherche Fédératif No 147, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq cedex, France
    Exp Cell Res 314:616-28. 2008
    ..Altogether, our results support a model whereby CyPB induces integrin-mediated adhesion via interaction with a multimolecular unit formed by the association between CD147, CD98 and beta1 integrins...
  29. ncbi L-type amino acid transporters LAT1 and LAT4 in cancer: uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo
    Cathleen Haase
    Department of Radiopharmaceutical Biology, Institute of Radiopharmacy, Research Center Dresden Rossendorf, Dresden, Germany
    J Nucl Med 48:2063-71. 2007
    ....
  30. ncbi Chloroquine, an anti-malarial agent, acts as a novel regulator of beta 1-integrin-mediated cell-cell adhesion
    Jae Youl Cho
    School of Bioscience and Biotechnology, and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200 701, Korea
    Biol Pharm Bull 31:726-30. 2008
    ..Therefore, these results suggest that chloroquine may act as a novel regulator of CD29 function in a lysomotropic character-dependent novel manner...
  31. ncbi Heteromeric amino acid transporters: biochemistry, genetics, and physiology
    J Chillaron
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona E 08028, Spain
    Am J Physiol Renal Physiol 281:F995-1018. 2001
    ..This review covers the biochemistry, human genetics, and cell physiology of HATs, including the multifunctional character of CD98...
  32. pmc Beta1 integrins show specific association with CD98 protein in low density membranes
    T V Kolesnikova
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    BMC Biochem 2:10. 2001
    ..Several lines of evidence suggest its functional interaction with integrins but the biochemical basis for this interaction has been unclear...
  33. ncbi SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance
    G Borsani
    Telethon Institute of Genetics and Medicine, San Raffaele Biomedical Science Park, Milan, Italy
    Nat Genet 21:297-301. 1999
    ..Furthermore, we detected a splice acceptor change resulting in a frameshift and premature translation termination in four unrelated Finnish patients. This mutation may represent the founder LPI allele in Finland...
  34. ncbi SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family
    M T Bassi
    Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Milan, Italy
    Genomics 62:297-303. 1999
    ....
  35. ncbi Overexpression of LAT1/CD98 light chain is sufficient to increase system L-amino acid transport activity in mouse hepatocytes but not fibroblasts
    W A Campbell
    Division of Medical Oncology, Brown University School of Medicine and Graduate Program in Pathobiology, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Biol Chem 276:16877-84. 2001
    ..We hypothesize that the altered LAT1 expression observed in hepatocarcinogenesis gives cells a growth or survival advantage through increased transport activity in a tumor microenvironment of limited amino acid availability...
  36. ncbi [Expression of lymphocyte activation markers in patients with gastrointestinal tumors at different stages]
    E K Oleinik
    Vopr Onkol 51:571-4. 2005
    ..A distinct activation phenotype can be identified for peripheral blood lymphocytes in burgeoning tumor which should be taken into account in prognosis...
  37. ncbi Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes
    J W Ritchie
    School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Am J Physiol Endocrinol Metab 280:E254-9. 2001
    ..Regulation of iodothyronine turnover in fat cells by this type of mechanism could contribute significantly to modulation of T4-T3/rT3 metabolism in the hypothyroid state...
  38. ncbi Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain
    Hideyo Sato
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Neurosci 22:8028-33. 2002
    ..The expression of system x(c)- in meninges and some circumventricular organs may suggest that this transporter contributes to the maintenance of the redox state (i.e., cysteine/cystine ratio) in the CSF...
  39. pmc Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2
    J A Lumadue
    Department of Human Genetics, Yale University, New Haven, CT 06511
    Proc Natl Acad Sci U S A 84:9204-8. 1987
    ....
  40. ncbi Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids
    M Pineda
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain
    J Biol Chem 274:19738-44. 1999
    ....
  41. pmc Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains
    A Bröer
    Division of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, ACT 0200, Australia
    Biochem J 355:725-31. 2001
    ..The results suggest that extracellular domains of the heavy chain are responsible mainly for recognition of light chains other than LAT1 and that the extracellular domain ensures proper translocation to the plasma membrane...
  42. ncbi RNA interference-induced reduction in CD98 expression suppresses cell fusion during syncytialization of human placental BeWo cells
    Yoshiki Kudo
    Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Hiroshima 734 8551, Japan
    FEBS Lett 577:473-7. 2004
    ..These findings show that CD98 is involved in the process of cell fusion necessary for syncytiotrophoblast formation...
  43. ncbi [Viral fusion mechanisms]
    Masato Tsurudome
    Department of Microbiology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Uirusu 55:207-19. 2005
    ..The crystal structures of F and the attachment protein HN have recently been clarified, which will facilitate studies of the molecular mechanism of F-mediated membrane fusion...
  44. doi Antibody epitope peptides as potential inducers of IgG antibodies against CD98 oncoprotein
    Kunihiko Itoh
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Cancer Sci 100:126-31. 2009
    ....
  45. doi l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
    Kyoichi Kaira
    Deparmtent of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Cancer Sci 99:2380-6. 2008
    ..Moreover, LAT1 expression was significantly correlated with cell proliferation and angiogenesis...
  46. ncbi Prediction of severe adverse drug reactions using pharmacogenetic biomarkers
    Masahiro Tohkin
    National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 25:122-33. 2010
    ..Key challenges for discovery of predictable risk alleles for these severe ADRs are also discussed...
  47. ncbi Genetic and biochemical characterization of a human surface determinant on somatic cell hybrids: the 4F2 antigen
    P G Peters
    Somatic Cell Genet 8:825-34. 1982
    ..This contrasts with results obtained from nonhybrid human cells of different lineages. These results demonstrate the importance of FACS techniques in the rapid mapping of genes which code human cell surface antigens...
  48. ncbi Cross-reactivity of monoclonal antibodies to defined human leucocyte differentiation antigens with bovine cells
    P Sopp
    Institute for Animal Health, Compton Laboratory, Newbury, Berkshire, UK
    Vet Immunol Immunopathol 56:11-25. 1997
    ....
  49. ncbi Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)
    Y Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181, Japan
    J Biol Chem 273:23629-32. 1998
    ..The cloning of LAT1 is expected to facilitate the research on the protein-protein interaction in the transporter field and to provide a clue to the search for still unidentified transporters...
  50. ncbi Cutting edge: primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid transporter E16
    M Tsurudome
    Department of Microbiology, Mie University School of Medicine, Tsu, Japan
    J Immunol 162:2462-6. 1999
    ..Resting monocytes and lymphocytes expressed CD98LC as analyzed by a newly isolated anti-CD98LC mAb, which showed cross-reactivity with insect Sf9 cells as well as with various mammalian cell lines...
  51. ncbi Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity
    H Segawa
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 274:19745-51. 1999
    ....
  52. ncbi Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling
    A Uren
    Laboratory of Cellular and Molecular Biology, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:4374-82. 2000
    ..These results provide new insights about the Wnt binding and biological activity of sFRPs...
  53. ncbi Cationic amino acid transport through system y+L in erythrocytes of patients with lysinuric protein intolerance
    C A Boyd
    Department of Human Anatomy and Genetics, University of Oxford, UK
    Pflugers Arch 439:513-6. 2000
    ..Polymerase chain reaction measurement of expression of these two genes in an erythroleukemic cell line suggests that alternatively there may be an as-yet-unidentified additional member of this gene family...
  54. ncbi 3-[123I]iodo-alpha-methyl-L-tyrosine transport and 4F2 antigen expression in human glioma cells
    K J Langen
    Institute of Medicine, Research Center Jülich GmbH, D 52425, Julich, Germany
    Nucl Med Biol 28:5-11. 2001
    ..We demonstrated that system L-mediated transport of IMT and 4F2 antigen expression are dependent on proliferation rate of human glioma cells and significantly correlated with each other...
  55. ncbi xCt cystine transporter expression in HEK293 cells: pharmacology and localization
    A Y Shih
    Department of Psychiatry, University of British Columbia, 4N1 2255 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada
    Biochem Biophys Res Commun 282:1132-7. 2001
    ..Our results indicate that HEK293 cells transfected with the xCT subunit would be a useful vehicle for future structure-function and pharmacology experiments involving system x(c)(-)...
  56. ncbi Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines
    O Yanagida
    Second Department of Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Biochim Biophys Acta 1514:291-302. 2001
    ..The properties of the hLAT1/h4F2hc complex would support the roles of this transporter in providing cells with essential amino acids for cell growth and cellular responses, and in distributing amino acid-related compounds...
  57. pmc Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytes
    Tatiana Uinuk-Ool
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Corrensstrasse 42, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 99:14356-61. 2002
    ..It reopens the question of the stage jawless fishes reached in the evolution of their immune system...
  58. ncbi System L: heteromeric exchangers of large, neutral amino acids involved in directional transport
    Francois Verrey
    University of Zurich, Institute of Physiology, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Pflugers Arch 445:529-33. 2003
    ..By mediating the regulated flux of these exchange substrates, unidirectional transporters control the activity of system L...
  59. ncbi The functional interaction between CD98 and CD147 in regulation of virus-induced cell fusion and osteoclast formation
    Kouki Mori
    Department of Microbiology, Mie University School of Medicine, 2 174 Edobashi, Tsu Shi, 514 8507 Mie Prefecture, Japan
    Med Microbiol Immunol 193:155-62. 2004
    ..Ab2 and 3 also suppressed CD98-mediated cell fusion of monocytes. This study indicates the functional interaction between CD98 and CD147 in the regulation of cell fusion...
  60. ncbi Activation of CEA-CAM-1-mediated cell adhesion via CD98: involvement of PKCdelta
    Kiyokazu Kakugawa
    Department of Biophysics, Graduate School of Science, Kyoto University, 606 8502 Kyoto, Japan
    FEBS Lett 552:184-8. 2003
    ..The results suggested that CD98 stimulation could activate CEA-CAM-1-mediated cell adhesion independently of integrins...
  61. ncbi Lateral membrane protein associations of CD4 in lymphoid cells detected by cross-linking and mass spectrometry
    Oliver K Bernhard
    Centre for Virus Research, Westmead Millennium Institute, National Centre for HIV Virology Research, Westmead Hospital and The University of Sydney, Darcy Road, Westmead, NSW 2145, Australia
    Biochemistry 43:256-64. 2004
    ..As both molecules undergo endocytic recycling, the association and cross-linking result from their clustering in the same pit and/or vesicle. The CD4-CD98 association probably results from nonspecific cross-linking...
  62. ncbi [Human monocyte-derived multinucleated giant cells]
    Hiroyuki Okamoto
    Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
    Nihon Hansenbyo Gakkai Zasshi 73:245-51. 2004
    ..Thus, an in vitro MGC formation model would be a useful tool to understand the relevance of MGC in granulomatous disorders...
  63. ncbi Bridge linkage role played by CD98hc of anti-tumor drug resistance and cancer metastasis on cisplatin-resistant ovarian cancer cells
    Hong Yang
    Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, Xi an, PR China
    Cancer Biol Ther 6:942-7. 2007
    ..CD147 has been reported to play an important role in tumor metastasis. Taken together, CD98hc was for the first time revealed to be a bridge between MDR phenotype and tumor metastasis...
  64. ncbi The molecular basis of macrophage fusion
    Laura Helming
    Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
    Immunobiology 212:785-93. 2007
    ..The function of MGCs during granulomatous diseases is currently unknown. However, a better understanding of the mechanistic basis of macrophage fusion may lead to a better understanding of the function of MGCs found in granulomas...
  65. pmc Ecto-phosphorylation of CD98 regulates cell-cell interactions
    Hang Thi Thu Nguyen
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 3:e3895. 2008
    ..Our findings reveal a novel mechanism involved in regulating the multiple functions of CD98 and raise CD98 as a promising target for therapeutic modulations of cell-cell interactions...
  66. doi Evaluation of thoracic tumors with (18)F-FMT and (18)F-FDG PET-CT: a clinicopathological study
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Int J Cancer 124:1152-60. 2009
    ..Our results suggest that coexpression of LAT1 and CD98 in addition to cell proliferation and angiogenesis is relavant for the progression and metastasis of lung cancer...
  67. pmc Induction of upregulation and downregulation of the T-cell activation marker CD98 in patients undergoing contrast-enhanced CT with iodinated non-ionic dimeric contrast medium
    Ingrid Böhm
    Department of Radiology, University of Bonn, Bonn, Germany
    Korean J Radiol 10:58-62. 2009
    ..This study was designed to determine prospectively the expression of the multifunctional CD98 protein in peripheral white blood cells in patients receiving iodinated contrast media (CM) for a computed tomography (CT) examination...
  68. doi Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus
    Nadine Gogolla
    Friedrich Miescher Institut, CH 4058 Basel, Switzerland
    Neuron 62:510-25. 2009
    ..Therefore, behavioral experience specifically regulates adult global stratum lucidum synapse numbers and hippocampal network structure through Wnt signaling...
  69. pmc LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
    Peter Tamas
    Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Eur J Immunol 40:242-53. 2010
    ..LBK1 was also required for survival and proliferation of peripheral T cells. These data thus reveal a conserved and essential role for LKB1 in the proliferative responses of both thymocytes and mature T cells...
  70. ncbi VLA-1: a T cell surface antigen which defines a novel late stage of human T cell activation
    M E Hemler
    Eur J Immunol 15:502-8. 1985
    ....
  71. pmc Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth
    E Quackenbush
    Proc Natl Acad Sci U S A 84:6526-30. 1987
    ..Southern blotting experiments have shown that the 4F2 heavy-chain cDNAs are derived from a single-copy gene that has been highly conserved during mammalian evolution...
  72. pmc Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation
    K M Gottesdiener
    Howard Hughes Medical Institute, University of Michigan, Ann Arbor 48109
    Mol Cell Biol 8:3809-19. 1988
    ....
  73. pmc Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms
    T Lindsten
    Howard Hughes Medical Institute, University of Michigan, Ann Arbor 48109
    Mol Cell Biol 8:3820-6. 1988
    ....
  74. ncbi The amino acid transport system y+L/4F2hc is a heteromultimeric complex
    R Estevez
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona 08028
    FASEB J 12:1319-29. 1998
    ..To our knowledge, this is the first direct evidence for a heteromultimeric protein structure of an organic solute carrier in mammals...
  75. ncbi Gene expression during osteoclast-like cell formation induced by antifusion regulatory protein-1/CD98/4F2 monoclonal antibodies (MAbs): c-src is selectively induced by anti-FRP-1 MAb
    Y Higuchi
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Mie Prefecture, Japan
    Bone 25:17-24. 1999
    ..On the other hand, no receptor activator of NF-KB ligand (RANKL) mRNA was detectable in any of the samples, suggesting that anti-FRP-1 mAb can induce osteoclast-like cells from blood monocytes without RANKL...
  76. ncbi Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein
    A Chairoungdua
    Department of Pharmacology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, USA
    J Biol Chem 274:28845-8. 1999
    ..The results from the present investigation were used to establish a family of amino acid transporters associated with type II membrane glycoproteins...
  77. ncbi Cloning and expression of a b(0,+)-like amino acid transporter functioning as a heterodimer with 4F2hc instead of rBAT. A new candidate gene for cystinuria
    D P Rajan
    Department of Biochemistry, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 274:29005-10. 1999
    ..Based on the characteristics of the transport process mediated by the 4F2hc/4F2-lc6 complex and the expression pattern of 4F2-lc6 in mammalian tissues, we suggest that 4F2-lc6 is a new candidate gene for cystinuria...
  78. ncbi Cloning and functional characterization of a Na(+)-independent, broad-specific neutral amino acid transporter from mammalian intestine
    D P Rajan
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912 2100, USA
    Biochim Biophys Acta 1463:6-14. 2000
    ..LAT2 is expressed primarily in the small intestine and kidney, whereas LAT1 exhibits a much broader tissue distribution...
  79. ncbi Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis
    B Jaspard
    INSERM U441, Avenue du Haut Leveque, 33 600, Pessac, France
    Mech Dev 90:263-7. 2000
    ..Immunoprecipitation experiments demonstrates that FrzA binds to mWnt-8 in cell culture experiments...
  80. ncbi Transport properties of a system y+L neutral and basic amino acid transporter. Insights into the mechanisms of substrate recognition
    Y Kanai
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 275:20787-93. 2000
    ..We further demonstrate that ry(+)LAT1, due to its peculiar cation dependence, mediates a heteroexchange, wherein the influx of substrate amino acids is accompanied by the efflux of basic amino acids...
  81. pmc The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine
    A Bröer
    Universitat Tubingen, Physiologisches Institut, Gmelinstr 5, 72076 Tubingen, Germany
    Biochem J 349:787-95. 2000
    ..These results indicated that arginine has the highest affinity for the intracellular binding site and that arginine release may be the main physiological function of this transporter...
  82. ncbi Glycoprotein-associated amino acid exchangers: broadening the range of transport specificity
    F Verrey
    Institute of Physiology, University of Zurich, Switzerland
    Pflugers Arch 440:503-12. 2000
    ....
  83. ncbi The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier
    T Kageyama
    Department of Neurology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, 606 8507, Kyoto, Japan
    Brain Res 879:115-21. 2000
    ..This is the first report showing that the 4F2hc/LAT1 complex participates in L-DOPA transport across the BBB...
  84. ncbi Induction of c-Src in human blood monocytes by anti-CD98/FRP-1 mAb in an Sp1-dependent fashion
    N Miyamoto
    Department of Microbiology, Department of Orthopedics, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Prefecture, 514 8507, Japan
    Cell Immunol 204:105-13. 2000
    ..Furthermore, anti-CD98HC mAb induced activation of tyrosine kinases and ERK kinases. These findings suggest that the tyrosine kinase(s)-Ras-MAPK-Sp1 pathway(s) is involved in CD98HC-mediated induction of c-Src in human blood monocytes...
  85. ncbi Molecular mechanisms affecting HTLV type 1-dependent fusion at the cell membrane: implications for inhibiting viral transmission
    S Daenke
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, England, UK
    AIDS Res Hum Retroviruses 16:1731-6. 2000
    ..These observations may be useful in the design of therapeutic agents to prevent HTLV-1 transmission...
  86. ncbi The zebrafish fth1, slc3a2, men1, pc, fgf3 and cycd1 genes define two regions of conserved synteny between linkage group 7 and human chromosome 11q13
    J A Yoder
    Children s Research Institute, University of South Florida College of Medicine All Children s Hospital, Department of Pediatrics, 140 Seventh Avenue South, FL 33701, St Petersburg, USA
    Gene 261:235-42. 2000
    ..These six genes, along with men1, fgf3 and cycd1 define two regions of conserved synteny between linkage group 7 and 11q13...
  87. ncbi Regulatory pathways and uptake of L-DOPA by capillary cerebral endothelial cells, astrocytes, and neuronal cells
    B Sampaio-Maia
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200-319 Porto, Portugal
    Am J Physiol Cell Physiol 280:C333-42. 2001
    ..Astrocytes, however, are endowed with other processes that appear to regulate the accumulation of L-DOPA, responding positively to increases in intracellular Ca2+ and cAMP and to decreases in cGMP...
  88. ncbi Cross-talk between RANKL and FRP-1/CD98 Systems: RANKL-mediated osteoclastogenesis is suppressed by an inhibitory anti-CD98 heavy chain mAb and CD98-mediated osteoclastogenesis is suppressed by osteoclastogenesis inhibitory factor
    K Mori
    Department of Microbiology, Mie University School of Medicine, 2-174, Edobashi, Tsu-Shi, Mie Prefecture, 514-8507, Japan
    Cell Immunol 207:118-26. 2001
    ..An inhibitory mAb directed against CD98hc, HBJ 127, shows a suppressive effect on RANKL-mediated cell aggregation and cell fusion. Thus, there is cross-talk between these two pathways...
  89. pmc Controlling tumor-derived and vascular endothelial cell growth: role of the 4Ff2 cell surface antigen
    M Papetti
    Department of Cellular and Molecular Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Pathol 159:165-78. 2001
    ....
  90. ncbi Phage display cloning and characterization of monoclonal antibody genes and recombinant Fab fragment against the CD98 oncoprotein
    K Itoh
    Department of Pharmaceutical Science, Akita University Hospital, Akita 010 8543, Japan
    Jpn J Cancer Res 92:1313-21. 2001
    ..To our knowledge, this is a first report of the production of anti-CD98 h.c. rFab fragment...
  91. ncbi Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes
    K Namba
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Prefecture, 514 8507, Japan
    Cell Immunol 213:104-13. 2001
    ..This is the first report that ADAM9 is involved in monocyte fusion, such as CD98-mediated and RANKL-mediated cell fusion of blood monocytes. Furthermore, AMAM9 is one candidate for a fusion peptide in blood monocytes...
  92. ncbi Interactions of integrins with their partner proteins in leukocyte membranes
    Howard R Petty
    Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA
    Immunol Res 25:75-95. 2002
    ..In this article we will highlight certain features of this growing field of research, especially with regard to their relevance in immunology and inflammation...
  93. ncbi The presence and prognostic importance of glomerular macrophage infiltration in renal allografts
    B Handan Ozdemir
    Department of Pathology, Faculty of Medicine, Baskent University, Ankara, Turkey
    Nephron 90:442-6. 2002
    ..The purpose of this study was to analyze the role of intraglomerular macrophage infiltration in human renal allografts by examining biopsies from kidney grafts that were dysfunctional after transplantation...
  94. ncbi Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression
    Hiromi Sasaki
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 277:44765-71. 2002
    ..EpRE occurs in a broad spectrum of genes for the proteins that are involved in the defense against xenobiotics and regulates their expression. The present results have demonstrated that xCT is a novel member of this protein family...
  95. ncbi Physical association and functional interaction between beta1 integrin and CD98 on human T lymphocytes
    Yuko J Miyamoto
    Department of Immunology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 180, Houston, TX 77030, USA
    Mol Immunol 39:739-51. 2003
    ..Differential extraction techniques and immunoprecipitations provided the first evidence that the alpha4beta1 integrin and CD98 are specifically associated on human T lymphocytes...
  96. pmc Manipulation of CD98 expression affects both trophoblast cell fusion and amino acid transport activity during syncytialization of human placental BeWo cells
    Yoshiki Kudo
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX and Nuffield Department of Obstetrics and Gynecology, John Radcliffe Hospital, Oxford, UK
    J Physiol 550:3-9. 2003
    ....
  97. ncbi The targeted disruption of the CD98 gene results in embryonic lethality
    Hideki Tsumura
    Functional Genomics Institutes, Life Science Research Center, Mie University, 2 174, Edobashi, Tsu Shi, Mie Prefecture 514 8507, Japan
    Biochem Biophys Res Commun 308:847-51. 2003
    ..The point of embryonic lethality is considered to be between 3.5 and 9.5 dps. These findings indicate that CD98 molecules are essential for mouse embryogenesis...
  98. ncbi Adenoviral modulation of the tumor-associated system L amino acid transporter, LAT1, alters amino acid transport, cell growth and 4F2/CD98 expressionwith cell-type specific effects in cultured hepatic cells
    Bill T Storey
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    Int J Cancer 117:387-97. 2005
    ..These studies are preparatory to in vivo efforts focusing on LAT1/CD98 as a potential therapeutic target...
  99. ncbi CD98, a novel marker of transient amplifying human keratinocytes
    Gilles Lemaitre
    Service de Génomique Fonctionnelle, CEA, Evry, France
    Proteomics 5:3637-45. 2005
    ..We then isolated CD98-positive keratinocytes from fresh skin biopsies. Using clonogenic assays, we demonstrate that CD98 may be considered as a marker of transient amplifying human keratinocytes...
  100. ncbi Role of integrins, tetraspanins, and ADAM proteins during the development of apoptotic bodies by spermatogenic cells
    Abraham L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education The City University of New York Medical School, New York, NY 10031, USA
    Mol Reprod Dev 73:906-17. 2006
    ..As a result, Sertoli cell reduction in surface area may be a limiting factor of spermatogenic cell survival and in the developmental regulation of spermatogenic cell progenies in the intact seminiferous epithelium...
  101. ncbi Activation antigens during the proliferative and secretory phases of endometrium and early-pregnancy decidua
    Yesim Ugur
    Department of Histology Embryology, Hacettepe University Medical Faculty, Ankara, Turkey
    Gynecol Obstet Invest 62:66-74. 2006
    ..Clarifying the normal distribution of activation antigens will contribute to database construction studies of monoclonal-antibody-based therapies in endometrial disorders...

Research Grants3

  1. CD98 (4F2 antigen) and Integrin Signaling in Vascular Smooth Muscle Cells.
    Dong Yun Lee; Fiscal Year: 2009
    ..The development of new therapeutic targets aimed at reducing vascular smooth muscle cell proliferation relies on studies such as this one that investigate the mechanism controlling vascular smooth muscle cell proliferation. ..
  2. HPEPT1 IN INTESTINAL INFLAMMATION
    Didier Merlin; Fiscal Year: 2003
    ..The project will involve a variety of biochemical methods with emphasis on molecular approaches. The completion of this proposal should molecularly define a link between an active transport process and intestinal inflammation. ..
  3. HPEPT1 IN INTESTINAL INFLAMMATION
    Didier Merlin; Fiscal Year: 2008
    ..The completion of this proposal should molecularly define a link between anL active transport process and intestinal inflammation. ..