immunodominant epitopes

Summary

Summary: Subunits of the antigenic determinant that are most easily recognized by the immune system and thus most influence the specificity of the induced antibody.

Top Publications

  1. ncbi Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    AIDS 17:2581-91. 2003
  2. ncbi Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 25:533-43. 2006
  3. pmc Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western Kenya
    Ann M Moormann
    Center for Global Health and Diseases, and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106 7286, USA
    Am J Trop Med Hyg 81:489-95. 2009
  4. pmc Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections
    Sherry R Crowe
    Trudeau Institute, P O Box 59, Saranac Lake, NY 12983, USA
    J Exp Med 198:399-410. 2003
  5. pmc Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon
    Fernando Rodriguez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:4251-9. 2002
  6. ncbi Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57
    Geraldine M A Gillespie
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    AIDS 16:961-72. 2002
  7. ncbi Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses
    Lydie Trautmann
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 601, Nantes, France
    J Immunol 175:6123-32. 2005
  8. pmc Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Virol 81:12382-93. 2007
  9. pmc Dynamics of immune escape during HIV/SIV infection
    Christian L Althaus
    Theoretical Biology, Utrecht University, The Netherlands
    PLoS Comput Biol 4:e1000103. 2008
  10. pmc Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, San Diego, CA 92037, USA
    J Immunol 182:2909-18. 2009

Research Grants

  1. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
  2. Mechanisms of Race-Based Differences in Factor VIII Immunogenicity in Hemophilia
    KATHLEEN PALMER PRATT; Fiscal Year: 2010
  3. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2013
  4. Chronic alcohol abuse disrupts CD8+T cell function
    Annette J Schlueter; Fiscal Year: 2013
  5. Diagnostic Assays for early Lyme Borreliosis using in-vivo expressed antigens
    Michel Ledizet; Fiscal Year: 2012
  6. Tony L Yaksh; Fiscal Year: 2016
  7. Rapid Diagnosis of Early TB in HIV+ Patients
    Suman Laal; Fiscal Year: 2013
  8. Edward F Rosloniec; Fiscal Year: 2014
  9. ANDREW E LEVIN; Fiscal Year: 2014
  10. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010

Detail Information

Publications247 found, 100 shown here

  1. ncbi Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    AIDS 17:2581-91. 2003
    ..However, their impact on viral replication during acute HIV-1 infection is not known...
  2. ncbi Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 25:533-43. 2006
    ..Here, I review work that has extended immunodominance studies to viruses of greater complexity and to the real world of human antiviral immunity...
  3. pmc Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen 1 and thrombospondin-related adhesive protein immunodominant epitopes in a highland population from Western Kenya
    Ann M Moormann
    Center for Global Health and Diseases, and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, 44106 7286, USA
    Am J Trop Med Hyg 81:489-95. 2009
    ....
  4. pmc Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections
    Sherry R Crowe
    Trudeau Institute, P O Box 59, Saranac Lake, NY 12983, USA
    J Exp Med 198:399-410. 2003
    ..Thus, differential antigen presentation impacts both the specificity of the T cell response and the efficacy of peptide-based vaccination strategies...
  5. pmc Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon
    Fernando Rodriguez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:4251-9. 2002
    ....
  6. ncbi Cross-reactive cytotoxic T lymphocytes against a HIV-1 p24 epitope in slow progressors with B*57
    Geraldine M A Gillespie
    MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    AIDS 16:961-72. 2002
    ....
  7. ncbi Selection of T cell clones expressing high-affinity public TCRs within Human cytomegalovirus-specific CD8 T cell responses
    Lydie Trautmann
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 601, Nantes, France
    J Immunol 175:6123-32. 2005
    ....
  8. pmc Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Virol 81:12382-93. 2007
    ....
  9. pmc Dynamics of immune escape during HIV/SIV infection
    Christian L Althaus
    Theoretical Biology, Utrecht University, The Netherlands
    PLoS Comput Biol 4:e1000103. 2008
    ....
  10. pmc Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, San Diego, CA 92037, USA
    J Immunol 182:2909-18. 2009
    ..2 is the major ligand for the CD28 receptor on VACV-specific CD8 T cells, that B7.2 can promote efficient CD8 T cell priming without B7.1, and that B7.1 and B7.2 can be differentially utilized during antiviral responses...
  11. pmc Immunogenicity of a fusion protein containing immunodominant epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in mice and active TB infection
    Eduardo Martins de Sousa
    Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, Goiania, Goias, Brazil
    PLoS ONE 7:e47781. 2012
    ..Sera from a cohort of individuals with active tuberculosis contained higher levels of IgG and IgM that recognized CMX when compared to healthy individuals. In conclusion, this protein was shown to be immunogenic both in mice and humans...
  12. ncbi Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses
    L K Selin
    Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
    Immunity 11:733-42. 1999
    ..These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime...
  13. ncbi HIV-1 epitope-specific CD8+ T cell responses strongly associated with delayed disease progression cross-recognize epitope variants efficiently
    Emma L Turnbull
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom
    J Immunol 176:6130-46. 2006
    ..A better understanding of the features of T cell responses associated with long-term control of viral replication should facilitate rational vaccine design...
  14. pmc Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication
    John T Loffredo
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 555 Science Dr, Madison, WI 53711, USA
    J Virol 82:1723-38. 2008
    ..Natural containment of AIDS virus replication in Mamu-B*08-positive macaques may, therefore, be related to a combination of immunodominance and viral escape from CD8(+) T-cell responses...
  15. pmc Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope
    Christoph Neumann-Haefelin
    Department of Medicine II, University of Freiburg, Germany
    Hepatology 51:54-62. 2010
    ..Finally, we found a significantly higher frequency of HLA-B27 positivity in patients with chronic HCV genotype 3a infection compared to genotype 1 infection, indicating that there is no protection by HLA-B27 in HCV genotype 3 infection...
  16. doi Elimination of immunodominant epitopes from multispecific DNA-based vaccines allows induction of CD8 T cells that have a striking antiviral potential
    Petra Riedl
    Department of Internal Medicine I, University of Ulm, Germany
    J Immunol 183:370-80. 2009
    ..Subdominant epitopes in vaccines can hence prime specific CD8 T cell immunity in a tolerogenic milieu that delivers specific antiviral effects to HBV-expressing hepatocytes...
  17. ncbi Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes
    Julian Schulze zur Wiesch
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 175:3603-13. 2005
    ..This comprehensive characterization of CD4(+) T cell epitopes in resolved HCV infection provides important information to facilitate studies of immunopathogenesis and HCV vaccine design and evaluation...
  18. pmc Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve
    Carla Oseroff
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 180:7193-202. 2008
    ..Together, these findings have clear implications for the design of CD8(+) T cell subunit vaccines and in particular raise the exciting prospect of being able to choose subunits without reference to MHC restriction...
  19. ncbi Relative dominance of HLA-B*07 restricted CD8+ T-lymphocyte immune responses to human cytomegalovirus pp65 in persons sharing HLA-A*02 and HLA-B*07 alleles
    Simon F Lacey
    Laboratory of Vaccine Research, Division of Virology, Beckman Institute of the City of Hope, City of Hope Medical Centre, Duarte, CA 91010, USA
    Hum Immunol 64:440-52. 2003
    ..This may have significant consequences for the design of epitope-specific vaccines...
  20. ncbi The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance
    Christopher A Lazarski
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    Immunity 23:29-40. 2005
    ..Taken collectively, our results suggest the half-life of class II:peptide complexes is the primary parameter that dictates the ultimate hierarchy of the elicited T cell response...
  21. ncbi Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus
    Michael Basler
    Division of Immunology, Department of Biology, University of Constance, Konstanz, Germany
    J Immunol 173:3925-34. 2004
    The cytotoxic T cell response to pathogens is usually directed against a few immunodominant epitopes, while other potential epitopes are either subdominant or not used at all...
  22. pmc Portable flanking sequences modulate CTL epitope processing
    Sylvie Le Gall
    Partners AIDS Research Center and Howard Hughes Medical Institute, Massachusetts General Hospital MGH, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 117:3563-75. 2007
    ..Such portable epitope processing determinants provide what we believe is a novel approach to optimizing CTL responses elicited by vaccine vectors...
  23. pmc CD8+ T cells in Trypanosoma cruzi infection
    Angel M Padilla
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    Curr Opin Immunol 21:385-90. 2009
    ..Changes in the frequency of parasite-specific T cell upon therapeutic treatment in humans may provide a new metric for determining treatment efficacy...
  24. ncbi Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
    S M Mansour Haeryfar
    Laboratory of Viral Diseases, National Institute of Allergies and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:3344-51. 2005
    ..Therefore, Treg influence TCD8 immunodominance hierarchies by moderating disparities in responses to different determinants...
  25. pmc Pathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology
    Cecilia B Marta
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, USA
    Proc Natl Acad Sci U S A 102:13992-7. 2005
    ....
  26. pmc Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A
    Mark A Brockman
    Partners AIDS Research Center, Massachusetts General Hospital East, CNY 6625, Charlestown, MA 02129, USA
    J Virol 81:12608-18. 2007
    ....
  27. ncbi Relevant antibody subsets against MOG recognize conformational epitopes exclusively exposed in solid-phase ELISA
    Til Menge
    University of California San Francisco, Department of Neurology, San Francisco CA, USA
    Eur J Immunol 37:3229-39. 2007
    ..Thus, the accurate detection of important subsets of pathogenic anti-MOG antibodies requires methods in which MOG is displayed similarly to its natural conformation in myelin...
  28. ncbi Immunodominant epitopes on the NS1 protein of MVE and KUN viruses serve as targets for a blocking ELISA to detect virus-specific antibodies in sentinel animal serum
    R A Hall
    Department of Microbiology, University of Western Australia, Nedlands
    J Virol Methods 51:201-10. 1995
    ..These assays are now used routinely in our laboratory for testing chicken sera from sentinel flocks in the Kimberley and Pilbara regions of north Western Australia...
  29. ncbi Genetic diversity of the Campylobacter genes coding immunodominant proteins
    D P Pawelec
    Institute of Microbiology, Warsaw University, Nowy OEwiat 67, 00 046, Warsaw, Poland
    FEMS Microbiol Lett 185:43-9. 2000
    ..Most of the observed nucleotide substitutions occurred at the third base of the codons. This observation is consistent with the results of Western blot experiments...
  30. pmc Major histocompatibility complex class II DR-restricted memory CD4(+) T lymphocytes recognize conserved immunodominant epitopes of Anaplasma marginale major surface protein 1a
    Wendy C Brown
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 70:5521-32. 2002
    ..The presence of multiple CD4(+) T-cell epitopes in the MSP1a HD, in addition to the neutralization-sensitive epitope, supports the testing of this immunogen for induction of protective immunity against A. marginale challenge...
  31. ncbi Immunodomination in the evolution of dominant epitope-specific CD8+ T lymphocyte responses in simian immunodeficiency virus-infected rhesus monkeys
    Michael H Newberg
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 176:319-28. 2006
    ....
  32. ncbi An altered T cell repertoire in MECL-1-deficient mice
    Michael Basler
    Division of Immunology, Department of Biology, University of Constance, Konstanz, Germany
    J Immunol 176:6665-72. 2006
    ..Taken together, our data reveal an in vivo function of MECL-1 in codetermining the T cell repertoire for an antiviral CTL response...
  33. ncbi Immunodominance and immunodomination: critical factors in developing effective CD8+ T-cell-based cancer vaccines
    Weisan Chen
    T Cell Laboratory, Ludwig Institute for Cancer Research, Austin Health, Heidelberg, VIC 3084, Australia
    Adv Cancer Res 95:203-47. 2006
    ..A full understanding of all the factors that control immunodominance and influence immunodomination will help us to develop better viral and cancer vaccines...
  34. pmc Modulation of DNA vaccine-elicited CD8+ T-lymphocyte epitope immunodominance hierarchies
    Jinyan Liu
    Research East Room 213, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 80:11991-7. 2006
    ..CD8(+) T-lymphocyte responses, however, are often highly focused on a very limited number of immunodominant epitopes. For an HIV-1 vaccine, the breadth of CD8(+) T-lymphocyte responses may prove to be critical as a result ..
  35. doi Development of a porcine reproductive and respiratory syndrome virus differentiable (DIVA) strain through deletion of specific immunodominant epitopes
    Marcelo de Lima
    Nebraska Center for Virology and Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, Lincoln, NE 68583 0900, USA
    Vaccine 26:3594-600. 2008
    ..To ascertain if one or more of these immunodominant epitopes can be used as the basis of DIVA differentiation, we selected two epitope markers previously identified ..
  36. pmc Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs
    Shadi Salloum
    University of Essen, Department of Virology, Virchowstrasse 179, 45147 Essen, Germany
    J Virol 82:11803-12. 2008
    ....
  37. doi Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response
    Zhenhai Chen
    Veterinary Science Department, South Dakota State University, Brookings, SD 57007, USA
    J Gen Virol 91:1047-57. 2010
    ..These results suggest that certain regions in nsp2 are non-essential for PRRSV replication but may play an important role in modulation of host immunity in vivo...
  38. pmc Polyfunctional CD4+ T cell responses to immunodominant epitopes correlate with disease activity of virulent Salmonella
    Matt Maybeno
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS ONE 7:e43481. 2012
    ..Moreover, we found that CD4(+) T cell responses against immunodominant epitopes are predictive for active Salmonella disease...
  39. ncbi Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium
    S J McSorley
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Immunol 164:986-93. 2000
    ..These clones were found to respond to an epitope from a constant region of FliC, enabling them to cross-react with flagellar proteins expressed by a number of distinct Salmonella serovars...
  40. ncbi Contribution of HLA class I allele expression to CD8+ T-cell responses against Epstein-Barr virus
    P Höllsberg
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Scand J Immunol 55:189-95. 2002
    ..This may have implications for EBV vaccine development as well as for the interpretation of isolated analysis of immunodominant responses to EBV...
  41. pmc Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis
    Patrice H Lalive
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:2280-5. 2006
    ....
  42. pmc CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance
    Charles S Rosenberg
    Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602, USA
    J Immunol 185:560-8. 2010
    ....
  43. ncbi Mutational analysis of the IgE epitopes in the latex allergen Hev b 5
    D H Beezhold
    Laboratory of Immunobiology, Guthrie Research Institute, 1 Guthrie Square, Sayre, PA 18840, USA
    J Allergy Clin Immunol 107:1069-76. 2001
    ..Changing a minimum of 3 immunodominant epitopes was required to cause a 100-fold reduction in IgE binding...
  44. pmc Immunogenicity of Mycobacterium tuberculosis RD1 region gene products in infected cattle
    A S Mustafa
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait
    Clin Exp Immunol 130:37-42. 2002
    ..In addition, we were able to identify 3 more antigens (Rv3871, Rv3872 and Rv3873), which induced immunological reactivity in PBMC from more than 50%M. bovis of infected cattle...
  45. pmc Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6
    Caroline Demangel
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 75724 Paris Cedex 15, France
    Infect Immun 72:2170-6. 2004
    ..Taken together, these results show that PPE68 is an immunogenic product of the RD1 region, which does not interfere with the secretion and immunogenicity of CFP-10 and ESAT-6...
  46. pmc Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection
    Todd M Allen
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    J Virol 76:10507-11. 2002
    ..By themselves, these strong CTL responses failed to control SIVmac239 replication...
  47. pmc Hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens in the context of MHC class I and class II molecules
    Maria R Parkhurst
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:5317-25. 2003
    ....
  48. pmc Expansion of protective CD8+ T-cell responses driven by recombinant cytomegaloviruses
    Urs Karrer
    Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom
    J Virol 78:2255-64. 2004
    ....
  49. ncbi Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models
    Jonathan W Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Immunity 21:149-53. 2004
    ....
  50. pmc Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein
    Jonah B Sacha
    Wisconsin National Primate Research Center WNPRC, Madison, WI 53711, USA
    J Virol 82:9293-8. 2008
    ..These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein...
  51. ncbi Beta-galactofuranose-containing O-linked oligosaccharides present in the cell wall peptidogalactomannan of Aspergillus fumigatus contain immunodominant epitopes
    Eduardo A Leitao
    Instituto de Microbiologia Professor Paulo de Goes, CCS Universidade Federal do Rio de Janeiro, 21944 970, Rio de Janeiro, RJ, Brasil
    Glycobiology 13:681-92. 2003
    ..The immunodominant epitopes were present in the tetra- and hexasaccharide, which contain a beta-Galf-(1 --> 5)-beta-Galf terminal ..
  52. ncbi Immunodominance of an antiviral cytotoxic T cell response is shaped by the kinetics of viral protein expression
    Hans Christian Probst
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    J Immunol 171:5415-22. 2003
    ..Thus, the observed absence of early CTL in persistent infections might not be the cause, but rather the consequence of viral persistence...
  53. ncbi H-2 class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies
    H Firat
    Unité d Immunité Cellulaire Antivirale, Département SIDA Rétrovirus, Institut Pasteur, Paris, France
    Eur J Immunol 29:3112-21. 1999
    ..Thus, HHD mice provide a versatile animal model for preclinical evaluation of peptide-based cancer immunotherapy...
  54. ncbi Immunodomination results from functional differences between competing CTL
    G Roy-Proulx
    Guy-Bernier Research Center, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada
    Eur J Immunol 31:2284-92. 2001
    ....
  55. pmc Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities
    Nicole Frahm
    Partners AIDS Research Center, Endocrine Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129 2000, USA
    J Virol 78:2187-200. 2004
    ..The present study thus identifies factors that contribute to the immunogenicity of these highly targeted and relatively conserved sequences in HIV that may represent promising vaccine candidates for ethnically heterogeneous populations...
  56. ncbi The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites
    Kota Arun Kumar
    Michael Heidelberger Division of Immunology, Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Nature 444:937-40. 2006
    ..Thus, although hundreds of other Plasmodium genes are expressed in sporozoites and EEFs, CS is a dominant protective antigen. Nevertheless, sterile immunity could be obtained by immunization of CS transgenics with three doses of IrSp...
  57. pmc Characterization of the fine specificity of bovine CD8 T-cell responses to defined antigens from the protozoan parasite Theileria parva
    Simon P Graham
    International Livestock Research Institute, PO Box 30709, Nairobi 00100, Kenya
    Infect Immun 76:685-94. 2008
    ..These data demonstrate that the identified antigens are inherently dominant in animals with the corresponding MHC genotypes...
  58. pmc Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sorting
    Marcus Folker Pahl-Seibert
    Institute for Virology, Johannes Gutenberg University, Hochhaus am Augustusplatz, 55101 Mainz, Germany
    J Virol 79:5400-13. 2005
    ..Compared with CTLLs specific for the same epitope and of comparable avidity and TCR beta-chain variable region (Vbeta)-defined polyclonality, sorted CD8-TM cells proved to be superior by more than 2 orders of magnitude...
  59. ncbi The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes
    Andrea J Sant
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Immunol Rev 207:261-78. 2005
    ..We discuss this model in the context of the existing data in the field of immunodominance...
  60. doi A4D12 monoclonal antibody recognizes a new linear epitope from SAG2A Toxoplasma gondii tachyzoites, identified by phage display bioselection
    Jair P Cunha-Junior
    Institute of Biomedical Sciences, Federal University of Uberlandia, Brazil
    Immunobiology 215:26-37. 2010
    ....
  61. doi Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance
    Stefan Tenzer
    Institute of Immunology, University of Mainz, Mainz, Germany
    Nat Immunol 10:636-46. 2009
    ..Our analyses show that antigen processing shapes CTL response hierarchies and that viral evolution modifies cleavage patterns and suggest strategies for in vitro vaccine optimization...
  62. pmc Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice
    Inge E A Flesch
    Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 184:45-55. 2010
    ..These data have implications for our understanding of the extent to which MHC diversity alters the range of epitopes that are immunogenic in outbred populations...
  63. pmc Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection
    Karen Fitzmaurice
    Department of Clinical Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Gut 60:1563-71. 2011
    ....
  64. pmc Viral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaques
    Thomas H Vanderford
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS Pathog 7:e1002048. 2011
    ..SIV mutants, we longitudinally assessed the presence of CTL escape variants in two MamuA*01-restricted immunodominant epitopes (Tat-SL8 and Gag-CM9) in the plasma, PBMCs, lymph nodes (LN), and rectal biopsies (RB) of fifteen SIV(..
  65. pmc Selective pressure to increase charge in immunodominant epitopes of the H3 hemagglutinin influenza protein
    Keyao Pan
    Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA
    J Mol Evol 72:90-103. 2011
    ..98 between 1968 and 1988). The RAMM model calibrated to historical H3N2 influenza virus evolution in humans fit well to the H3N2/Wyoming virus evolution data from Guinea pig animal model studies...
  66. pmc Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination
    Rafaela Holtappels
    Institute for Virology, Johannes Gutenberg University, Hochhaus am Augustusplatz, 55131 Mainz, Germany
    J Virol 82:5781-96. 2008
    ..We conclude that protection is, rather, based on the collective antiviral potential of non-IDEs independent of the presence or absence of IDE-mediated immunodomination...
  67. doi CTL induction by cross-priming is restricted to immunodominant epitopes
    Viktor Pavelic
    Department of Clinical Research, University of Berne, Berne, Switzerland
    Eur J Immunol 39:704-16. 2009
    ..Cross-priming was observed for the immunodominant epitopes LCMV-gp33 and -np118, although direct induction resulted in higher CTL frequencies...
  68. ncbi CTL response to Mycobacterium tuberculosis: identification of an immunogenic epitope in the 19-kDa lipoprotein
    N Mohagheghpour
    Kuzell Institute for Arthritis and Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco 94115, USA
    J Immunol 161:2400-6. 1998
    ..tb. These results demonstrate that M.tb19 elicits HLA class I-restricted CTLs in vitro and in vivo that recognize endogenously processed Ag. Epitopes of the type identified here may prove useful in the design of an M.tb vaccine...
  69. ncbi Rapid induction of specific cytotoxic T lymphocytes against melanoma-associated antigens by a recombinant vaccinia virus vector expressing multiple immunodominant epitopes and costimulatory molecules in vivo
    Daniel Oertli
    Division of General Surgery, Department of Surgery, University Hospital Basel, CH 4031 Basel, Switzerland
    Hum Gene Ther 13:569-75. 2002
    ..Clinical effectiveness of this immunologically active protocol should therefore be explored in appropriately selected groups of patients...
  70. pmc Immunodominant epitopes in Babesia bovis rhoptry-associated protein 1 that elicit memory CD4(+)-T-lymphocyte responses in B. bovis-immune individuals are located in the amino-terminal domain
    Junzo Norimine
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology Animal Disease Research Unit, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 70:2039-48. 2002
    ..The presence of T-helper-cell epitopes in the NT domain of RAP-1, which is highly conserved among otherwise antigenically different strains of B. bovis, supports the inclusion of this region in vaccine constructs to be tested in cattle...
  71. ncbi T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
    Michael A Brehm
    Department of Pathology and Progranm in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Nat Immunol 3:627-34. 2002
    ..Thus, immunodominance is a function of the host's previous exposure to unrelated pathogens, and this may have an impact on protective immunity and immunopathology...
  72. ncbi Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily
    Xiao lin He
    Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, Cailfornia 94305 5124, USA
    Nat Struct Biol 9:606-11. 2002
    ....
  73. ncbi Production of monospecific antibody to immunodominant epitopes of the caprine arthritis encephalitis virus transmembrane glycoprotein and analysis of their activity in vitro
    Sophie Dufour
    Institute of Veterinary Virology, University of Bern, Bern, Switzerland
    Intervirology 45:177-82. 2002
    ..encephalitis virus (CAEV)-infected goats develop high titers of nonneutralizing antibody to several immunodominant epitopes of the viral envelope glycoprotein...
  74. pmc The differential ability of HLA B*5701+ long-term nonprogressors and progressors to restrict human immunodeficiency virus replication is not caused by loss of recognition of autologous viral gag sequences
    Stephen A Migueles
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 77:6889-98. 2003
    ..Qualitative features of the virus-specific CD8(+) T-cell response not measured by current assays remain the most likely determinants of the differential abilities of HLA B(*)5701(+) LTNPs and progressors to restrict virus replication...
  75. ncbi Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus
    Peter Gergely
    Section of Rheumatology, Department of Medicine, State University of New York, Upstate Medical University, College of Medicine, Syracuse, NY 13210, USA
    Clin Immunol 116:124-34. 2005
    ..To identify cross-reactive viral antigens capable of triggering autoreactivity, HRES-1/p28 epitopes were mapped by SLE antibodies...
  76. ncbi Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses
    Florian Bihl
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, 02129, USA
    J Immunol 176:4094-101. 2006
    ..The data support the important role of HLA-B alleles in antiviral immunity and afford a better understanding of the factors contributing to inter- and intraindividual immunodominance...
  77. pmc Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry
    Markus Cornberg
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Virol 81:934-44. 2007
    ....
  78. pmc Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection
    Hayley Crawford
    Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 81:8346-51. 2007
    ..These data may help explain the observed association between HLA-B*5703 and long-term control of viremia...
  79. ncbi Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design
    Andrea J Sant
    David H Smith Center for Vaccine Biology and Immunology, Aab Institute and Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Expert Rev Vaccines 6:357-68. 2007
    ....
  80. ncbi Heterologous expression of FMDV immunodominant epitopes and HSP70 in P. pastoris and the subsequent immune response in mice
    Chunxia Su
    Key Laboratory of Animal Diseases Diagnosis and Immunology of China s Department of Agriculture, Nanjing Agricultural University, Jiangsu, Nanjing 210095, PR China
    Vet Microbiol 124:256-63. 2007
    ..The most prominent immune responses arose from vaccination with the EG-HSP70 fusion product. Both fusion protein-induced Th1-like cytokine (IFN-gamma) and Th2-like cytokine (IL-4) were identified...
  81. doi Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes
    Stephen M Thirdborough
    Cancer Sciences Division, University of Southampton School of Medicine, SGH, Southampton, UK
    Eur J Immunol 38:364-9. 2008
    ..Our findings reveal strategies for activating T cells against low-affinity peptides, of potential importance for patients with repertoires narrowed by deletional tolerance...
  82. pmc Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects
    Min Kim
    Centre for Virus Research, Westmead Millennium Institute, Westmead, New South Wales and University of Sydney, New South Wales, Australia
    J Immunol 181:6604-15. 2008
    ..Using a set of 39 overlapping 20-mer peptides, more than six immunodominant epitopes were defined in gD2 (two to six peptide epitopes were recognized for each subject)...
  83. doi Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells
    Stefan Ebert
    Institute for Virology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Strasse 67, Hochhaus am Augustusplatz, 55131 Mainz, Germany
    Med Microbiol Immunol 201:541-50. 2012
    ..that 'immunodominance' indicates 'relevance' in antiviral control, research interest was focused on the immunodominant epitopes (IDEs) and their potential use in immunotherapy and in vaccines...
  84. pmc Acinetobacter baumannii rOmpA vaccine dose alters immune polarization and immunodominant epitopes
    Lin Lin
    Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles Medical Center, Torrance, CA 90502, United States
    Vaccine 31:313-8. 2013
    ..The rOmpA vaccine has been shown to protect mice from lethal infection caused by extreme-drug-resistant (XDR) Acinetobacter baumannii. The role of dose in immunology of the rOmpA vaccine was explored...
  85. ncbi Identification of immunodominant epitopes in the filamentous hemagglutinin of Bordetella pertussis
    G Piatti
    Institute of Microbiology, University of Genova, Italy
    FEMS Immunol Med Microbiol 23:235-41. 1999
    ..the use of this protein for vaccine purposes it would be helpful to define the regions encompassing immunodominant epitopes. Twelve recombinant plasmids have been generated encoding fusion proteins between fragments of the ..
  86. ncbi An antigen-targeted approach to adoptive transfer therapy of cancer
    D Valmori
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, University Hospital, CHUV, Lausanne, Switzerland
    Cancer Res 59:2167-73. 1999
    ..Altogether, these results pave the way to a molecularly defined approach to antigen-specific adoptive transfer therapy of cancer...
  87. pmc Identification of immunodominant epitopes derived from the respiratory syncytial virus fusion protein that are recognized by human CD4 T cells
    Grada M van Bleek
    Laboratory for Vaccine Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Virol 77:980-8. 2003
    ..Detailed knowledge about immunodominant antigenic peptides will facilitate the ability to monitor CD4 T-cell responses in patients and the measurement of correlates of protection in vaccinated subjects...
  88. ncbi Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1
    Christopher M Smith
    Cooperative Research Center for Vaccine Technology, University of Melbourne, Victoria, Australia
    J Immunol 170:4437-40. 2003
    ..Given that such class I-restricted presentation is essential for CTL priming, this implies that these conventional CD8alpha(+) dendritic cells are the key subset involved in CTL immunity to this virus...
  89. pmc In vivo expansion of the residual tumor antigen-specific CD8+ T lymphocytes that survive negative selection in simian virus 40 T-antigen-transgenic mice
    Todd D Schell
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Virol 78:1751-62. 2004
    ..the thymus of SV11 mice results in the deletion of CD8(+) T cells specific for the three H2(b)-restricted immunodominant epitopes of T-Ag...
  90. pmc A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes
    Isamu Z Hartman
    Graduate Program in Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 16:1333-40. 2010
    ..Our reductionist system successfully identified the physiologically selected immunodominant epitopes of two model antigens: hemagglutinin-1 (HA1) from influenza virus (A/Texas/1/77) and type II collagen (..
  91. pmc Epitope specificity of myeloperoxidase antibodies: identification of candidate human immunodominant epitopes
    B F Bruner
    Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Clin Exp Immunol 164:330-6. 2011
    ..These results provide major common human anti-MPO immunodominant antigenic targets which can be used to examine further the potential pathogenic mechanisms for these autoantibodies...
  92. pmc Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations
    Christoph Neumann-Haefelin
    Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA
    Hepatology 54:1157-66. 2011
    ..Coexpression of these upstream mutations with the rare escape mutations dramatically restored viral replication capacity from <5% to ≥ 70% of wild-type levels...
  93. ncbi Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura
    M Kuwana
    Institute for Advanced Medical Research and the Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Blood 98:130-9. 2001
    ..These results indicate that the immunodominant epitopes recognized by pathogenic CD4(+) T cells in patients with ITP are located within the amino-terminal ..
  94. pmc Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
    David M Koelle
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:12899-904. 2003
    ..We conclude that among circulating cells expressing a homing-associated receptor, during chronic herpes type 2 infection, the CD8 T cell response becomes quite focused despite the presence of many potential antigenic peptides...
  95. pmc Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides
    Daniel E Kaufmann
    Partners AIDS Research Center and Infectious Disease Unit, Howard Hughes Medical Institute, Massachusetts General Hospital, and Division of AIDS, Boston, Massachusetts 02114, USA
    J Virol 78:4463-77. 2004
    ..These findings have implications for the design of immunotherapeutic strategies and for testing candidate HIV vaccines...
  96. ncbi Immunoproteasome-deficient mice mount largely normal CD8+ T cell responses to lymphocytic choriomeningitis virus infection and DNA vaccination
    Alexander K Nussbaum
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 175:1153-60. 2005
    ..We conclude that the immunoproteasome may affect T cell responses to only a limited number of viral epitopes, and we propose that its main biological function may lie elsewhere...
  97. pmc Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals
    Junbao Yang
    Benaroya Research Institute at Virginia Mason, Seattle, WA, USA
    Int Immunol 21:63-71. 2009
    ..protein residues 159-171, 166-178, 449-461 and 1083-1097 were identified to contain naturally processed immunodominant epitopes based on strong in vitro T cell responses of PBMC (as assayed by tetramer staining) to intact spike ..
  98. pmc Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response
    Eva Dazert
    Department of Molecular Virology, University of Heidelberg, Heidelberg, Germany
    J Clin Invest 119:376-86. 2009
    ..These results suggest that protection by HLA-B27 in HCV infection can be explained by the requirement to accumulate a cluster of mutations within the immunodominant epitope to escape T cell recognition...
  99. pmc Comprehensive mapping of common immunodominant epitopes in the West Nile virus nonstructural protein 1 recognized by avian antibody responses
    Encheng Sun
    The Key Laboratory of Veterinary Public Health, Harbin Veterinary Research Institute, Ministry of Agriculture, Chinese Academy of Agricultural Sciences, Harbin, People s Republic of China
    PLoS ONE 7:e31434. 2012
    ..The knowledge and reagents generated in this study have potential applications in differential diagnostic approaches and subunit vaccines development for WNV and other viruses of the JEV serocomplex...
  100. pmc Analysis of genetic variability within the immunodominant epitopes of envelope gp41 from human immunodeficiency virus type 1 (HIV-1) group M and its impact on HIV-1 antibody detection
    J Dorn
    HIV Immunology and Diagnostics Branch, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevntion, Atlanta, Georgia 30333, USA
    J Clin Microbiol 38:773-80. 2000
    ....
  101. pmc Absence of gamma-interferon-inducible lysosomal thiol reductase in melanomas disrupts T cell recognition of select immunodominant epitopes
    M Azizul Haque
    Department of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis, IN 46202, USA
    J Exp Med 195:1267-77. 2002
    ..Such disparities in the profile of antigenic epitopes displayed by tumors and bystander APCs may contribute to tumor cell survival in the face of immunological defenses...

Research Grants63

  1. Cellular Immunity to Category A-C Viruses in Humans
    ROBERT WILLIAM FINBERG; Fiscal Year: 2013
    ..Project 4 will analyze the mechanisms underlying the selection of immunodominant epitopes from large DMA viruses, including poxviruses and herpesviruses (HHV-6)...
  2. Mechanisms of Race-Based Differences in Factor VIII Immunogenicity in Hemophilia
    KATHLEEN PALMER PRATT; Fiscal Year: 2010
    ..test directly the hypothesis that amino acid sequences encoded by F8 loci containing ns-SNPs comprise immunodominant epitopes that, when allogeneically mismatched, stimulate T cells of HA patients...
  3. Gene Expression in HSV-1 Latency After Corneal Infection
    Paul R Kinchington; Fiscal Year: 2013
    ..This could indicate those HSV-1 proteins that could be potentially exploited in vaccine design to block reactivation when immunological pressure causes loss of immunodominant epitopes.
  4. Chronic alcohol abuse disrupts CD8+T cell function
    Annette J Schlueter; Fiscal Year: 2013
    ..In this component we will examine CDS functional responses to CDS immunodominant epitopes and other stimuli...
  5. Diagnostic Assays for early Lyme Borreliosis using in-vivo expressed antigens
    Michel Ledizet; Fiscal Year: 2012
    ..burgdorferi, and other infectious and rheumatic diseases. Peptide pin arrays will map the immunodominant epitopes of candidate antigens with Lyme disease sera in an ELISA format for incorporation into a refined ..
  6. Tony L Yaksh; Fiscal Year: 2016
    ..proteolysis of myelin basic protein (MBP) by matrix metalloproteinases (MMPs) releases the cryptic immunodominant epitopes, MBP84-104 and MBP69-86, normally sheltered from immunosurveillance...
  7. Rapid Diagnosis of Early TB in HIV+ Patients
    Suman Laal; Fiscal Year: 2013
    ..and correlate the presence of Abs with bacteriological confirmation of TB (Aim 2) and identify the immunodominant epitopes on the 5 antigens recognized by serum Abs from Indian patients on peptide microarrays to define peptides ..
  8. Edward F Rosloniec; Fiscal Year: 2014
    ..VA Public ..
  9. ANDREW E LEVIN; Fiscal Year: 2014
    ..S. Northeast and Midwest endemic regions. To identify immunodominant epitopes that may further improve assay sensitivity, we have identified a series of putative Babesia antigenic ..
  10. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    ..of autoantigen specific epitopes recognized by MHC class I restricted CD8+ T cells and identify the immunodominant epitopes. We will also determine the precursor frequency of CD8+ CTLs and, using the immunodominant epitope ..
  11. SCT PROBES FOR VIRAL IMMUNITY
    Ted Hansen; Fiscal Year: 2009
    ..immunity, we have engineered MHC class I molecules as peptide-preloaded single chains (or SCTs), defined immunodominant epitopes detected by CD8 T cells after West Nile virus (WNV) infection, and characterized novel T cell receptor ..
  12. TB Diagnosis Based on Promiscuous PE-PGRS Epitopes
    Suman Laal; Fiscal Year: 2010
    ..Our preliminary studies demonstrate that immunodominant epitopes that are shared by several PE-PGRS proteins (promiscuous epitopes) are highly immunogenic in TB patients...
  13. Ricin toxin: Neutralizing antibodies and vaccine design
    Nicholas J Mantis; Fiscal Year: 2013
    ....
  14. Development of a polyvalent chimeric vaccine for Lyme disease
    Richard T Marconi; Fiscal Year: 2010
    ..In aim 1we will identify the immunodominant epitopes of each OspC type and determine if each elicits a bactericidal Ab response...
  15. Nicotine & Immunopathogenesis of Cryptococcal meningitis
    Mohan Sopori; Fiscal Year: 2007
    ..delayed-type hypersensitivity responses to cryptococcal antigens, and generation of cytotoxic T cells to immunodominant epitopes of Cne proteins, as well as to evaluate the protective function of T cells that migrate into the brain ..
  16. Cell Free System for Identification of MHC Class II Immunodominant Epitopes
    Scheherazade Sadegh-Nasseri; Fiscal Year: 2011
    ..Thus, methods for determining MHC-restricted immunodominant epitopes would be more accurate if all of the steps preceding antigen presentation were inclusively integrated ..
  17. Scheherazade Sadegh-Nasseri; Fiscal Year: 2015
    ..this application addresses a mechanistic study aimed at understanding the steps involved in generation of immunodominant epitopes. Immunodominance is a phenomenon that has long been recognized but yet remains unclear to date...
  18. Molecular Mechanisms of HLA-DO in Antigen Processing
    Scheherazade Sadegh-Nasseri; Fiscal Year: 2013
    ..the mechanism of action of MHC class II accessory protein, HLA-DO and its role in generation of immunodominant epitopes. Immunodominance is a phenomenon that has long been recognized but yet remains unclear to date...
  19. CAMPYLOBACTER PYLORIDIS IN GASTRODUODENAL DISEASE
    David Graham; Fiscal Year: 1991
    ..pyloridis infection. An ELISA assay will be developed to identify those immunodominant epitopes of C. pyloridis antigens arising from current or past infection by C. pyloridis...
  20. DEVELOPMENT OF A FIMBRIN VACCINE AGAINST OTITIS MEDIA
    LAUREN BAKALETZ; Fiscal Year: 1999
    ..heterologous challenge; 2) use overlapping synthetic peptides to "map" the fimbrin subunit in terms of immunodominant epitopes and eukaryotic cell-binding domains; and 3) to employ several in vitro and in vivo models of adherence ..
  21. STEPHEN JAMES TILL; Fiscal Year: 2014
    ..T cells enriched and analysed freshly ex vivo using tetramers labelled with grass pollen immunodominant epitopes as well as with transcriptome analysis...
  22. Identifying and closing gaps in TCR coverage of HIV-1 escape
    Otto O Yang; Fiscal Year: 2011
    ..The specific aims are: 1) To isolate TCR for CTL responses against immunodominant epitopes presented by protective HLA types (which have been shown to have limited options for epitope mutation and ..
  23. High Potency HIV-1 Broadly Cross-Reactive Neutralization
    Gerald V Quinnan; Fiscal Year: 2012
    ..with cross-reactive neutralization epitopes compete poorly in germinal center reactions with the more immunodominant epitopes presented by monomeric gp120 that induce neutralizing antibodies with limited cross-reactivity...
  24. Evaluation of the Antigenicity of Black Restricted FVIII Haplotypes and Haplotype
    James W Lillard; Fiscal Year: 2013
    ..The ns-SNPs that define the H3 and H4 haplotypes reside within immunodominant epitopes of FVIII...
  25. The Immune Response to Factor VIII
    JOHN S LOLLAR; Fiscal Year: 2010
    ..There are two Specific Aims in this project. In Aim 1, novel immunodominant epitopes recognized by anti-factor VIII antibodies produced in a murine hemophilia A immunogenicity model will be ..
  26. HEPATITIS C IN CLINICALLY DISCORDANT HEMOPHILIC SIBLINGS
    Michael Fried; Fiscal Year: 2002
    ..abstract_text> ..
  27. PROTEINS OF CANDIDA ALBICANS AN AIDS-RELATED PATHOGEN
    Paula Sundstrom; Fiscal Year: 1993
    ..albicans via chemical crosslinking. Finally, studies to identify potential targets for anti-fungal therapy will be initiated by mapping adherent as welll as immunodominant domains on the protein...
  28. Development of RhCMV Vectors for SIV Infection
    Louis J Picker; Fiscal Year: 2010
    ..is distinct from responses elicited by conventional viral vectors or SIV itself, excluding the typical immunodominant epitopes that are internally processed in and presented by virally infected cells...
  29. Genomic Approaches to the T Cell Receptor Repertoire during Aging
    Ning Jiang; Fiscal Year: 2012
    ..T cell receptor sequence repertoire with ligand repertoire and phenotype in T cells specific for CMV immunodominant epitopes isolated from young and elderly cohorts Aim 3...
  30. Ning Jiang; Fiscal Year: 2015
    ..T cell receptor sequence repertoire with ligand repertoire and phenotype in T cells specific for CMV immunodominant epitopes isolated from young and elderly cohorts Aim 3...
  31. NCI CLINICAL INVESTIGATOR AWARD
    Kemp Cease; Fiscal Year: 1990
    ..It is hoped that such studies may eventually elucidate strategies for induction of antigen-specific T cell immunity to human malignancies...
  32. LDV-INDUCED GENETICALLY RESTRICTED CNS DISEASE
    MARGO BRINTON; Fiscal Year: 1991
    ..since this protein should contain both the binding site for attachment to host cells and the immunodominant epitopes which elicit the host immune response...
  33. Intradermal vaccinia:T-cell specificity and skin homing
    David Koelle; Fiscal Year: 2005
    ..2) Determine their fine specificity, and 1.3) Measure the magnitude of responses to immunodominant epitopes. Aim 2 will measure the expression and function of skin-homing-associated adhesion and chemokine receptor ..
  34. Dendritic cell targeted hepatitis c virus immunotherapy
    Tyler Curiel; Fiscal Year: 2003
    ..We further hypothesize that NS3 can be structurally modified in order to eliminate the immunodominant epitopes and therefore recruit new T cells against HCV...
  35. HELPER T CELL EPITOPE IMMUNODOMINANCE
    Samuel Landry; Fiscal Year: 2000
    ..The mechanism of immunodominance and the properties of immunodominant epitopes are largely unknown...
  36. Immunodominant epitopes of a smallpox vaccine in humans
    R Buller; Fiscal Year: 2003
    ..The Specific Aims are to: 1. Characterize the antibody responses to immunodominant vaccinia virus proteins and 2. Identify the epitope specificity of representative vaccinia virus-specific T cell clones. ..
  37. Novel Smallpox Vaccine Derived from VV/VAR Immunome
    Anne De Groot; Fiscal Year: 2006
    ..that are conserved between the vaccinia virus (W) and Variola (Var) genomes will be screened for immunodominant epitopes by computer-driven (EpiMatrix) analysis and confirmed using T cells from VV-immunized individuals...
  38. Priming CD4+ T cells to protect against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2004
    ..In Aim 1, we will determine the immunodominant epitopes recognized by V protein-specific CD4 + T cells and develop assays for enumerating V-specific T cells...
  39. IMMUNE MECHANISMS OF CHRONIC ALLOGRAFT REJECTION
    Charles Carpenter; Fiscal Year: 2000
    ..antibodies to TCRV/Beta families to block recognition in vivo, will test the significance of priming to immunodominant epitopes in chronic rejection...
  40. PROINSULIN EXPRESSION IN THE IMMUNE SYSTEM
    Alberto Pugliese; Fiscal Year: 2000
    ..Proinsulin shares most immunodominant epitopes with insulin, a major target autoantigen in Type I diabetes...
  41. Role of DM in generation in immunodominant epitope(s)
    Scheherazade Sadegh Nasseri; Fiscal Year: 2005
    ..proposal are to evaluate the role of DM, a non-classical MHC class II heterodimer, in the selection of immunodominant epitopes from a given protein...
  42. TCR Genes and HIV-Specific Cytotoxic T-lymphocytes
    Spyros Kalams; Fiscal Year: 2006
    ..CTL responses to HIV epitopes comparatively little is known about the diversity of the TCR repertoire to immunodominant epitopes and how the breadth and avidity of this repertoire influences subsequent viremia...
  43. NEUTROPHIL AUTOANTIBODIES IN VASCULITIS AND NEPHRITIS
    Ronald Falk; Fiscal Year: 2000
    ..It is hypothesized that: 1) the ANCA autoimmune response is directed against a limited number of immunodominant epitopes; 2) ANCA production results from the expression of limited combinations of VDJ genes; 3) precursor B ..
  44. A GENOME-DERIVED, EPITOPE-DRIVEN TULAREMIA VACCINE
    Anne De Groot; Fiscal Year: 2005
    ..tularensis genes that encode transmembrane, heat shock and secreted proteins will be screened for immunodominant epitopes by computer-driven (EpiMatrix) analysis of the bacterial genome...
  45. Identifying the properties of LLO required for MHC class I presentation
    Jody Melton Witt; Fiscal Year: 2009
    ..to LLO, and 2) In vitro characterization of the properties of LLO necessary for the generation of immunodominant epitopes. Relevance: Using Lm to deliver tumor antigens to the cytosol of host cells, it has been shown that the ..
  46. DELIVERY OF BIOPOLYMERS USING CATIONIC PEPTIDES
    Lawrence Steinman; Fiscal Year: 1999
    ....
  47. HUMAN HEPATOMA CELL SURFACE PROTEIN P50
    Mehmet Ozturk; Fiscal Year: 1992
    ..We will determine its primary structure by N-terminal sequencing. We will also analyze immunodominant epitopes by generating new monoclonal antibodies to the purified protein...
  48. CRYPTIC EPITOPES--IMMUNIZATION BY MULTIPLE CHAIN PEPTIDE
    Fred Valentine; Fiscal Year: 2001
    ..This failure results, at least in part, from the fact that the immunodominant epitopes are hypervariable, T cell responses are directed to a limited number of epitopes, and antibody responses ..
  49. CTL RECOGNITION OF DOMINANT AND CRYPTIC HIV-1 EPITOPES
    Premlata Shankar; Fiscal Year: 2000
    ..of CTL will ultimately depend on their ability to kill infected CD4+ cells, CTL directed against immunodominant epitopes or those induced experimentally will be tested for effectiveness in killing HIV infected CD4 targets...
  50. Virus Specific CTL following T cell depleted SCT
    Kenneth Lucas; Fiscal Year: 2009
    ..of the CTL donors will be compared with those found in CTL recipients post-infusion, to determine whether immunodominant epitopes recognized by the donor are retained in the recipient, and if not, which epitopes are most relevant post-..
  51. CELLULAR MECHANISMS OF PTLD IN TRANSPLANT RECIPIENTS
    OLIVIA MARTINEZ; Fiscal Year: 2002
    ..In Specific Aim 3 MHC/peptide tetramers containing immunodominant epitopes of EBV antigens will be used to identify EBV-specific CD8+ T cells in transplant recipients and the ..
  52. T CELL REACTIVITY TO GAD65 IN DIABETES
    Roland Tisch; Fiscal Year: 2002
    ..clones from unimmunized NOD mice representing different stages of disease development and determine the immunodominant epitopes that are recognized...
  53. VH Peptide Vaccine Strategies for B Cell Lymphomas
    Richard Bankert; Fiscal Year: 2003
    ..seen may be due to the elicitation of a limited immune response to single or very restricted set of immunodominant epitopes when whole Ig is used as the vaccine...
  54. T CELL RECOGNITION OF MYELIN IN MULTIPLE SCLEROSIS
    David Hafler; Fiscal Year: 2003
    ..These experiments will provide insights that may be important for the design of antigen specific immunotherapies for patients with multiple sclerosis. ..
  55. Immunogenicity of Listeria-derived antigens
    Alice Sijts; Fiscal Year: 2009
    ..These studies will enlarge our understanding of the determinants of immunodominance and are of great importance for vaccine design. ..
  56. Pathogenesis of Clade C HIV Infection
    Bruce D Walker; Fiscal Year: 2010
    ..initial and persistent containment of viremia, and to determine the preferred mutations that arise at immunodominant epitopes targeted in clade C virus infection, which makes up the majority of global cases...
  57. GENE THERAPY FOR TREATMENT OF AUTOIMMUNE DISEASES
    Marco Melo; Fiscal Year: 2001
    ..4) To test if our findings in the EAE model can be applied to another autoimmune models, e.g., collagen induced arthritis. ..
  58. DAMPENING IMMUNODOMINANT EPITOPES
    Peter Nara; Fiscal Year: 1999
    ..Recent research aimed at dampening or masking one of these immunodominant epitopes, V3, resulted in the development of a novel approach to shift the immune response to more conserved parts ..
  59. T CELL RECOGNITION OF ANTIGEN
    Alison Finnegan; Fiscal Year: 1992
    ..Specifically, this proposal will determine if these changes have an affect on antigen recognition by either altering that portion of the antigen that is recognized by the T cell receptor or by the Ia molecule...
  60. BINDING OF HIV PEPTIDES TO CLASS II MHC ON HUMAN CELLS
    Benvenuto Pernis; Fiscal Year: 1992
    ..Therefore, our work should be relevant not only for studies aiming at the definition of the immune status of H.I.V. infected individuals, but also for the design of vaccines that include synthetic H.I.V. peptides...
  61. HUMAN LYME BORRELIOSIS--COORDINATE T & B CELL RESPONSES
    David Volkman; Fiscal Year: 1992
    ..Defining T and B cell immunodominant epitopes, delineating the nature of lymphokine production by immune T cells, and clarifying the mechanisms by ..
  62. CYTOTOXIC T LYMPHOCYTE ACTIVITY AGAINST AUTOLOGOUS GP120
    Charles Rinaldo; Fiscal Year: 1999
    ..e., the role of quasispecies diversity and immune escape in HIV-1 disease progression. The results should be of importance to delineation of appropriate vaccine and therapeutic strategies for HIV-1 infection. ..
  63. P GINGIVALIS HSP90 RECOGNITION IN PERIODONTAL DISEASE
    Domenica Sweier; Fiscal Year: 2003
    ..gingivalis hsp90 gene homologue, (2) express the P. gingivalis hsp90 gene homologue and harvest the protein, and (3) map the immunodominant epitopes recognized in health and disease.