coxiella burnetii

Summary

Summary: A species of gram-negative bacteria that grows preferentially in the vacuoles of the host cell. It is the etiological agent of Q FEVER.

Top Publications

  1. Aguilera M, Salinas R, Rosales E, Carminati S, Colombo M, Berón W. Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii. Infect Immun. 2009;77:4609-20 pubmed publisher
    Q fever is a disease caused by Coxiella burnetii. In the host cell, this pathogen generates a large parasitophorous vacuole (PV) with lysosomal characteristics...
  2. Wang Y, Xiong X, Wu D, Wang X, Wen B. Efficient activation of T cells by human monocyte-derived dendritic cells (HMDCs) pulsed with Coxiella burnetii outer membrane protein Com1 but not by HspB-pulsed HMDCs. BMC Immunol. 2011;12:52 pubmed publisher
    b>Coxiella burnetii is an obligate intracellular bacterium and the etiologic agent of Q fever; both coxiella outer membrane protein 1 (Com1) and heat shock protein B (HspB) are its major immunodominant antigens...
  3. Socolovschi C, Reynaud P, Kernif T, Raoult D, Parola P. Rickettsiae of spotted fever group, Borrelia valaisiana, and Coxiella burnetii in ticks on passerine birds and mammals from the Camargue in the south of France. Ticks Tick Borne Dis. 2012;3:355-60 pubmed publisher
    ..The presence of Coxiella burnetii, Rickettsia, Borrelia, and Bartonella was examined by real-time PCR on DNA samples extracted from 118 ticks...
  4. Anderson A, Baker T, Littrell A, Mott R, Niebuhr D, Smoak B. Seroepidemiologic survey for Coxiella burnetii among hospitalized US troops deployed to Iraq. Zoonoses Public Health. 2011;58:276-83 pubmed publisher
    ..b>Coxiella burnetii antibody testing was performed and epidemiologic data were analysed from 909 servicemembers...
  5. Omsland A, Heinzen R. Life on the outside: the rescue of Coxiella burnetii from its host cell. Annu Rev Microbiol. 2011;65:111-28 pubmed publisher
    For over seven decades, Coxiella burnetii, the causative agent of human Q fever, has been considered a prototypical obligate intracellular bacterium that relies exclusively on a eukaryotic cell for growth...
  6. van der Hoek W, Meekelenkamp J, Dijkstra F, Notermans D, Bom B, Vellema P, et al. Proximity to goat farms and Coxiella burnetii seroprevalence among pregnant women. Emerg Infect Dis. 2011;17:2360-3 pubmed publisher
    ..Results confirmed that presence of antibodies against Coxiella burnetii is related to proximity to infected dairy goat farms...
  7. Mahamat A, Edouard S, Demar M, Abboud P, Patrice J, La Scola B, et al. Unique clone of Coxiella burnetii causing severe Q fever, French Guiana. Emerg Infect Dis. 2013;19:1102-4 pubmed publisher
    Acute Q fever is an emergent and severe disease in French Guiana. We obtained 5 Coxiella burnetii isolates from samples of patients from Cayenne and found an epidemic clone circulating in Cayenne...
  8. Astobiza I, Barandika J, Ruiz Fons F, Hurtado A, Povedano I, Juste R, et al. Four-year evaluation of the effect of vaccination against Coxiella burnetii on reduction of animal infection and environmental contamination in a naturally infected dairy sheep flock. Appl Environ Microbiol. 2011;77:7405-7 pubmed publisher
    Vaccination is considered one of the best options for controlling Coxiella burnetii infection in livestock. The efficacy of a phase I vaccine was investigated over 4 years in a sheep flock with confirmed C. burnetii infection...
  9. Kersh G, Lambourn D, Raverty S, Fitzpatrick K, Self J, Akmajian A, et al. Coxiella burnetii infection of marine mammals in the Pacific Northwest, 1997-2010. J Wildl Dis. 2012;48:201-6 pubmed
    Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. Humans are commonly exposed via inhalation of aerosolized bacteria derived from the waste products of domesticated sheep and goats, and particularly from products ..
  10. van den Brom R, Schimmer B, Schneeberger P, Swart W, van der Hoek W, Vellema P. Seroepidemiological survey for Coxiella burnetii antibodies and associated risk factors in Dutch livestock veterinarians. PLoS ONE. 2013;8:e54021 pubmed publisher
    ..burnetii when treating occupational risk groups, bearing in mind that the burden of disease among veterinarians remains uncertain. Vaccination of occupational risk groups should be debated. ..

Detail Information

Publications106 found, 100 shown here

  1. Aguilera M, Salinas R, Rosales E, Carminati S, Colombo M, Berón W. Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii. Infect Immun. 2009;77:4609-20 pubmed publisher
    Q fever is a disease caused by Coxiella burnetii. In the host cell, this pathogen generates a large parasitophorous vacuole (PV) with lysosomal characteristics...
  2. Wang Y, Xiong X, Wu D, Wang X, Wen B. Efficient activation of T cells by human monocyte-derived dendritic cells (HMDCs) pulsed with Coxiella burnetii outer membrane protein Com1 but not by HspB-pulsed HMDCs. BMC Immunol. 2011;12:52 pubmed publisher
    b>Coxiella burnetii is an obligate intracellular bacterium and the etiologic agent of Q fever; both coxiella outer membrane protein 1 (Com1) and heat shock protein B (HspB) are its major immunodominant antigens...
  3. Socolovschi C, Reynaud P, Kernif T, Raoult D, Parola P. Rickettsiae of spotted fever group, Borrelia valaisiana, and Coxiella burnetii in ticks on passerine birds and mammals from the Camargue in the south of France. Ticks Tick Borne Dis. 2012;3:355-60 pubmed publisher
    ..The presence of Coxiella burnetii, Rickettsia, Borrelia, and Bartonella was examined by real-time PCR on DNA samples extracted from 118 ticks...
  4. Anderson A, Baker T, Littrell A, Mott R, Niebuhr D, Smoak B. Seroepidemiologic survey for Coxiella burnetii among hospitalized US troops deployed to Iraq. Zoonoses Public Health. 2011;58:276-83 pubmed publisher
    ..b>Coxiella burnetii antibody testing was performed and epidemiologic data were analysed from 909 servicemembers...
  5. Omsland A, Heinzen R. Life on the outside: the rescue of Coxiella burnetii from its host cell. Annu Rev Microbiol. 2011;65:111-28 pubmed publisher
    For over seven decades, Coxiella burnetii, the causative agent of human Q fever, has been considered a prototypical obligate intracellular bacterium that relies exclusively on a eukaryotic cell for growth...
  6. van der Hoek W, Meekelenkamp J, Dijkstra F, Notermans D, Bom B, Vellema P, et al. Proximity to goat farms and Coxiella burnetii seroprevalence among pregnant women. Emerg Infect Dis. 2011;17:2360-3 pubmed publisher
    ..Results confirmed that presence of antibodies against Coxiella burnetii is related to proximity to infected dairy goat farms...
  7. Mahamat A, Edouard S, Demar M, Abboud P, Patrice J, La Scola B, et al. Unique clone of Coxiella burnetii causing severe Q fever, French Guiana. Emerg Infect Dis. 2013;19:1102-4 pubmed publisher
    Acute Q fever is an emergent and severe disease in French Guiana. We obtained 5 Coxiella burnetii isolates from samples of patients from Cayenne and found an epidemic clone circulating in Cayenne...
  8. Astobiza I, Barandika J, Ruiz Fons F, Hurtado A, Povedano I, Juste R, et al. Four-year evaluation of the effect of vaccination against Coxiella burnetii on reduction of animal infection and environmental contamination in a naturally infected dairy sheep flock. Appl Environ Microbiol. 2011;77:7405-7 pubmed publisher
    Vaccination is considered one of the best options for controlling Coxiella burnetii infection in livestock. The efficacy of a phase I vaccine was investigated over 4 years in a sheep flock with confirmed C. burnetii infection...
  9. Kersh G, Lambourn D, Raverty S, Fitzpatrick K, Self J, Akmajian A, et al. Coxiella burnetii infection of marine mammals in the Pacific Northwest, 1997-2010. J Wildl Dis. 2012;48:201-6 pubmed
    Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. Humans are commonly exposed via inhalation of aerosolized bacteria derived from the waste products of domesticated sheep and goats, and particularly from products ..
  10. van den Brom R, Schimmer B, Schneeberger P, Swart W, van der Hoek W, Vellema P. Seroepidemiological survey for Coxiella burnetii antibodies and associated risk factors in Dutch livestock veterinarians. PLoS ONE. 2013;8:e54021 pubmed publisher
    ..burnetii when treating occupational risk groups, bearing in mind that the burden of disease among veterinarians remains uncertain. Vaccination of occupational risk groups should be debated. ..
  11. Hildebrandt A, Straube E, Neubauer H, Schmoock G. Coxiella burnetii and coinfections in Ixodes ricinus ticks in Central Germany. Vector Borne Zoonotic Dis. 2011;11:1205-7 pubmed publisher
    ..ricinus ticks were collected in 2006 and 2007 in a forest region of Central Germany and investigated for Coxiella burnetii. The transposase element IS1111 and isocitrate dehydrogenase gene were targets of the real-time polymerase ..
  12. Larson C, Beare P, Howe D, Heinzen R. Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis. Proc Natl Acad Sci U S A. 2013;110:E4770-9 pubmed publisher
    Successful macrophage colonization by Coxiella burnetii, the cause of human Q fever, requires pathogen-directed biogenesis of a large, growth-permissive parasitophorous vacuole (PV) with phagolysosomal characteristics...
  13. Astobiza I, Barral M, Ruiz Fons F, Barandika J, Gerrikagoitia X, Hurtado A, et al. Molecular investigation of the occurrence of Coxiella burnetii in wildlife and ticks in an endemic area. Vet Microbiol. 2011;147:190-4 pubmed publisher
    At present few studies have been carried out on the distribution and incidence of Coxiella burnetii infection in wildlife. Therefore, the aim of this study was to investigate the distribution of C...
  14. de Bruin A, de Groot A, De Heer L, Bok J, Wielinga P, Hamans M, et al. Detection of Coxiella burnetii in complex matrices by using multiplex quantitative PCR during a major Q fever outbreak in The Netherlands. Appl Environ Microbiol. 2011;77:6516-23 pubmed publisher
    Q fever, caused by Coxiella burnetii, is a zoonosis with a worldwide distribution. A large rural area in the southeast of the Netherlands was heavily affected by Q fever between 2007 and 2009...
  15. Sprong H, Tijsse Klasen E, Langelaar M, de Bruin A, Fonville M, Gassner F, et al. Prevalence of Coxiella burnetii in ticks after a large outbreak of Q fever. Zoonoses Public Health. 2012;59:69-75 pubmed publisher
    ..Goat farms are probably the prime source from which Coxiella burnetii have spread throughout the environment, infecting people living in the vicinity...
  16. Havas K, Burkman K. A comparison of the serological evidence of Coxiella burnetii exposure between military working dogs and feral canines in Iraq. Mil Med. 2011;176:1101-3 pubmed
    b>Coxiella burnetii is the causative agent of the zoonotic disease Q fever. Military working dogs (MWDs) are exposed to disease while deployed and are a potential source for human infection...
  17. Layez C, Brunet C, Lépolard C, Ghigo E, Capo C, Raoult D, et al. Foxp3(+)CD4(+)CD25(+) regulatory T cells are increased in patients with Coxiella burnetii endocarditis. FEMS Immunol Med Microbiol. 2012;64:137-9 pubmed publisher
    Chronic Q fever, which principally manifests as endocarditis, is characterized by Coxiella burnetii persistence and an impaired cell-mediated immune response...
  18. Angelakis E, Raoult D. Q Fever. Vet Microbiol. 2010;140:297-309 pubmed publisher
    Q fever is a zoonotic disease caused by the ubiquitous pathogen Coxiella burnetii responsible for acute and chronic clinical manifestations...
  19. Hansen M, Rodolakis A, Cochonneau D, Agger J, Christoffersen A, Jensen T, et al. Coxiella burnetii associated placental lesions and infection level in parturient cows. Vet J. 2011;190:e135-9 pubmed publisher
    Cotyledons (n=170) from dairy cattle were analysed for Coxiella burnetii by real-time (rt) PCR targeting the IS1111a and icd genes...
  20. Agger J, Christoffersen A, Rattenborg E, Nielsen J, Agerholm J. Prevalence of Coxiella burnetii antibodies in Danish dairy herds. Acta Vet Scand. 2010;52:5 pubmed publisher
    During recent years in Denmark higher rates of antibodies to Coxiella burnetii have been detected in animals and humans than previously reported...
  21. Roest H, van Gelderen B, Dinkla A, Frangoulidis D, van Zijderveld F, Rebel J, et al. Q fever in pregnant goats: pathogenesis and excretion of Coxiella burnetii. PLoS ONE. 2012;7:e48949 pubmed publisher
    b>Coxiella burnetii is an intracellular bacterial pathogen that causes Q fever. Infected pregnant goats are a major source of human infection...
  22. Jones R, Twomey D, Hannon S, Errington J, Pritchard G, Sawyer J. Detection of Coxiella burnetii in placenta and abortion samples from British ruminants using real-time PCR. Vet Rec. 2010;167:965-7 pubmed publisher
    A real-time PCR was developed to detect Coxiella burnetii (the cause of Q fever) in ruminant placentas and aborted fetuses...
  23. Rosales E, Aguilera M, Salinas R, Carminati S, Colombo M, Martinez Quiles N, et al. Cortactin is involved in the entry of Coxiella burnetii into non-phagocytic cells. PLoS ONE. 2012;7:e39348 pubmed publisher
    ..Numerous pathogens exploit the phagocytic process and actin cytoskeleton to infect host cells. Coxiella burnetii, the etiologic agent of Q fever, is internalized by host cells through a molecular mechanism that is poorly ..
  24. Astobiza I, Barandika J, Ruiz Fons F, Hurtado A, Povedano I, Juste R, et al. Coxiella burnetii shedding and environmental contamination at lambing in two highly naturally-infected dairy sheep flocks after vaccination. Res Vet Sci. 2011;91:e58-63 pubmed publisher
    Abortion due to Coxiella burnetii was confirmed in the 2007/08 season in two naturally-infected dairy sheep flocks. Proportion of C...
  25. Taurel A, Guatteo R, Joly A, Seegers H, Beaudeau F. Seroprevalence of Q fever in naturally infected dairy cattle herds. Prev Vet Med. 2011;101:51-7 pubmed publisher
    b>Coxiella burnetii is the causal agent of Q fever, a worldwide spread zoonosis. Prevention of C. burnetii shedding in cattle is critical to control the spread of the pathogen between animals, and from animals to humans...
  26. Jado I, Carranza Rodriguez C, Barandika J, Toledo A, García Amil C, Serrano B, et al. Molecular method for the characterization of Coxiella burnetii from clinical and environmental samples: variability of genotypes in Spain. BMC Microbiol. 2012;12:91 pubmed publisher
    b>Coxiella burnetii is a highly clonal microorganism which is difficult to culture, requiring BSL3 conditions for its propagation. This leads to a scarce availability of isolates worldwide...
  27. de Bruin A, Janse I, Koning M, De Heer L, van der Plaats R, van Leuken J, et al. Detection of Coxiella burnetii DNA in the environment during and after a large Q fever epidemic in the Netherlands. J Appl Microbiol. 2013;114:1395-404 pubmed publisher
    To investigate the Coxiella burnetii DNA content in environmental samples that may contribute to the transmission of C. burnetii.
  28. Courcoul A, Vergu E, Denis J, Beaudeau F. Spread of Q fever within dairy cattle herds: key parameters inferred using a Bayesian approach. Proc Biol Sci. 2010;277:2857-65 pubmed publisher
    Q fever is a worldwide zoonosis caused by Coxiella burnetii. Although ruminants are recognized as the most important source of human infection, no previous studies have focused on assessing the characteristics of the bacterial spread ..
  29. Rodolakis A. Q Fever in dairy animals. Ann N Y Acad Sci. 2009;1166:90-3 pubmed publisher
    ..The number of Coxiella shed in milk is generally low. The phase I vaccine prevented abortion and greatly decreased the shedding of C. burnetii in milk...
  30. Muskens J, van Maanen C, Mars M. Dairy cows with metritis: Coxiella burnetii test results in uterine, blood and bulk milk samples. Vet Microbiol. 2011;147:186-9 pubmed publisher
    In cattle, Coxiella burnetii infections are generally asymptomatic but can also be associated with reproductive disorders. Metritis is considered as one of the symptoms of C. burnetii infections, but reliable information is lacking...
  31. Sukocheva O, Marmion B, Storm P, Lockhart M, Turra M, Graves S. Long-term persistence after acute Q fever of non-infective Coxiella burnetii cell components, including antigens. QJM. 2010;103:847-63 pubmed publisher
    ..of asymptomatic and QFS patients had Q fever antibody and also low levels in PBMC and bone marrow of Coxiella burnetii (C.b...
  32. Campoy E, Mansilla M, Colombo M. Endocytic SNAREs are involved in optimal Coxiella burnetii vacuole development. Cell Microbiol. 2013;15:922-41 pubmed publisher
    b>Coxiella burnetii is a Gram-negative intracellular bacterium. As previously described, both the endocytic and the autophagic pathways contribute to the maturation of Coxiella replicative vacuoles (CRVs)...
  33. Loftis A, Priestley R, Massung R. Detection of Coxiella burnetii in commercially available raw milk from the United States. Foodborne Pathog Dis. 2010;7:1453-6 pubmed publisher
    ..Raw milk (n=21; cow, 14; goat, 7) was purchased in 12 states, and Coxiella burnetii, the agent of Q fever, was detected in 9 of 21 (42.9%) samples tested by polymerase chain reaction...
  34. Minnick M, Raghavan R. Genetics of Coxiella burnetii: on the path of specialization. Future Microbiol. 2011;6:1297-314 pubmed publisher
    b>Coxiella burnetii is an extremely infectious, zoonotic agent that causes Q fever in humans. With the exception of New Zealand, the bacterium is distributed worldwide...
  35. Wallménius K, Pettersson J, Jaenson T, Nilsson K. Prevalence of Rickettsia spp., Anaplasma phagocytophilum, and Coxiella burnetii in adult Ixodes ricinus ticks from 29 study areas in central and southern Sweden. Ticks Tick Borne Dis. 2012;3:100-6 pubmed publisher
    ..Six of the ticks (0.7%) were infected with an Anaplasma sp., presumably A. phagocytophilum. Coxiella burnetii DNA was not detected in any of the ticks. The detection of R. helvetica and A...
  36. Narasaki C, Toman R. Lipopolysaccharide of Coxiella burnetii. Adv Exp Med Biol. 2012;984:65-90 pubmed publisher
    ..LPS) is considered to be one of the major determinants of virulence expression and infection of virulent Coxiella burnetii. The LPSs from virulent phase I (LPS I) and from avirulent phase II (LPS II) bacteria were investigated for ..
  37. Amara A, Bechah Y, Mege J. Immune response and Coxiella burnetii invasion. Adv Exp Med Biol. 2012;984:287-98 pubmed publisher
    b>Coxiella burnetii, the causative agent of Q fever, has evolved a wealth of mechanisms in order to persist within hosts. Two tissues, namely adipose tissue and placenta, are candidates to house C. burnetii, but the mechanisms governing C...
  38. Czopowicz M, Kaba J, Szalus Jordanow O, Nowicki M, Witkowski L, Nowicka D, et al. Prevalence of antibodies against Chlamydophila abortus and Coxiella burnetii in goat herds in Poland. Pol J Vet Sci. 2010;13:175-9 pubmed
    An epidemiological study was carried out to determine the herd prevalence of Chlamydophila abortus and Coxiella burnetii antibodies in goats covered by a milk recording program in Poland...
  39. van der Hoek W, Meekelenkamp J, Leenders A, Wijers N, Notermans D, Hukkelhoven C. Antibodies against Coxiella burnetii and pregnancy outcome during the 2007-2008 Q fever outbreaks in The Netherlands. BMC Infect Dis. 2011;11:44 pubmed publisher
    Q fever has become a major public health problem in The Netherlands. Infection with Coxiella burnetii (Q fever) during pregnancy has resulted in adverse pregnancy outcome in the majority of reported cases...
  40. Bacci S, Villumsen S, Valentiner Branth P, Smith B, Krogfelt K, Mølbak K. Epidemiology and clinical features of human infection with Coxiella burnetii in Denmark during 2006-07. Zoonoses Public Health. 2012;59:61-8 pubmed publisher
    ..virtually unknown in Denmark in 2005, when, after the introduction of new sensitive diagnostic methods for Coxiella burnetii, an increasing number of positive cattle created concern among people with frequent exposure...
  41. Delsing C, Warris A, Bleeker Rovers C. Q fever: still more queries than answers. Adv Exp Med Biol. 2011;719:133-43 pubmed publisher
    ..Doxycycline is the treatment of choice for acute infection. An alternative for young children and pregnant women is cotrimoxazole. Chronic infection requires long term treatment usually with doxycycline combined with hydroxychloroquine...
  42. Kantsø B, Svendsen C, Jørgensen C, Krogfelt K. Comparison of two commercially available ELISA antibody test kits for detection of human antibodies against Coxiella burnetii. Scand J Infect Dis. 2012;44:489-94 pubmed publisher
    Q fever is a zoonosis caused by Coxiella burnetii. The disease is emerging in many parts of the world, likely in part due to increased awareness and the availability of better diagnostic tests...
  43. Gyuranecz M, Denes B, Hornok S, Kovacs P, Horvath G, Jurkovich V, et al. Prevalence of Coxiella burnetii in Hungary: screening of dairy cows, sheep, commercial milk samples, and ticks. Vector Borne Zoonotic Dis. 2012;12:650-3 pubmed publisher
    Q fever is an important zoonotic disease caused by Coxiella burnetii. There are few reliable data about C. burnetii infection available...
  44. Knobel D, Maina A, Cutler S, Ogola E, Feikin D, Junghae M, et al. Coxiella burnetii in humans, domestic ruminants, and ticks in rural western Kenya. Am J Trop Med Hyg. 2013;88:513-8 pubmed publisher
    We conducted serological surveys for Coxiella burnetii in archived sera from patients that visited a rural clinic in western Kenya from 2007 to 2008 and in cattle, sheep, and goats from the same area in 2009...
  45. Schneeberger P, Hermans M, van Hannen E, Schellekens J, Leenders A, Wever P. Real-time PCR with serum samples is indispensable for early diagnosis of acute Q fever. Clin Vaccine Immunol. 2010;17:286-90 pubmed publisher
    ..Therefore, we evaluated the performance of a real-time PCR for detection of Coxiella burnetii DNA using serum samples from patients with acute Q fever...
  46. Tilburg J, Horrevorts A, Peeters M, Klaassen C, Rossen J. Identification by genotyping of a commercial antigen preparation as the source of a laboratory contamination with Coxiella burnetii and as an unexpected rich source of control DNA. J Clin Microbiol. 2011;49:383-4 pubmed publisher
    ..It was established that such antigen preparations contain relatively high loads of DNA/RNA, making them potential sources of contamination but also convenient preparations for control material...
  47. Wei Y, Wang X, Xiong X, Wen B. Coxiella burnetii antigen-stimulated dendritic cells mediated protection against Coxiella burnetii in BALB/c mice. J Infect Dis. 2011;203:283-91 pubmed publisher
    b>Coxiella burnetii is the etiological agent of human Q fever. In this study, adaptive transfer of mouse bone marrow-derived dendritic cells (BMDCs) stimulated with C...
  48. Healy B, van Woerden H, Raoult D, Graves S, Pitman J, Lloyd G, et al. Chronic Q fever: different serological results in three countries--results of a follow-up study 6 years after a point source outbreak. Clin Infect Dis. 2011;52:1013-9 pubmed publisher
    Acute and chronic Q fever/Coxiella burnetii infection is diagnosed principally by serology. The management of patients who have serological evidence of chronic Q fever but no other manifestation of chronic infection is challenging.
  49. Cooper A, Goullet M, Mitchell J, Ketheesan N, Govan B. Serological evidence of Coxiella burnetii exposure in native marsupials and introduced animals in Queensland, Australia. Epidemiol Infect. 2012;140:1304-8 pubmed publisher
    ..The aim of this study was to determine the seroprevalence of Coxiella burnetii in Australian native animals and introduced animals in northern and southeastern Queensland...
  50. Leon A, Richard E, Fortier C, Laugier C, Fortier G, Pronost S. Molecular detection of Coxiella burnetii and Neospora caninum in equine aborted foetuses and neonates. Prev Vet Med. 2012;104:179-83 pubmed publisher
    ..Among others, Chlamydophila abortus (1 case), Coxiella burnetii (6 cases) and Neospora caninum (3 cases) were detected by real-time PCR; one of these samples being co-..
  51. Taurel A, Guatteo R, Joly A, Beaudeau F. Effectiveness of vaccination and antibiotics to control Coxiella burnetii shedding around calving in dairy cows. Vet Microbiol. 2012;159:432-7 pubmed publisher
    Effectiveness of phase 1 vaccine, combined or not with tetracycline, to control Coxiella burnetii vaginal shedding at calving in cows was assessed through a 13 months study in 22 Q fever clinically affected commercial dairy herds...
  52. Mertens K, Samuel J. Defense mechanisms against oxidative stress in Coxiella burnetii: adaptation to a unique intracellular niche. Adv Exp Med Biol. 2012;984:39-63 pubmed publisher
    ..Comparison with E. coli as a model bacterium reveals that defense strategies of C. burnetii differ significantly and emphasize a highly adaptive evolution to this harsh and unique niche...
  53. Banazis M, Bestall A, Reid S, Fenwick S. A survey of Western Australian sheep, cattle and kangaroos to determine the prevalence of Coxiella burnetii. Vet Microbiol. 2010;143:337-45 pubmed publisher
    The objective of this study was to investigate the prevalence of Coxiella burnetii in two domestic ruminant species (cattle and sheep) and the western grey kangaroo (Macropus fuliginosus) in Western Australia (WA)...
  54. Textoris J, Ban L, Capo C, Raoult D, Leone M, Mege J. Sex-related differences in gene expression following Coxiella burnetii infection in mice: potential role of circadian rhythm. PLoS ONE. 2010;5:e12190 pubmed publisher
    Q fever, a zoonosis due to Coxiella burnetii infection, exhibits sexual dimorphism; men are affected more frequently and severely than women for a given exposure. Here we explore whether the severity of C...
  55. Mahapatra S, Ayoubi P, Shaw E. Coxiella burnetii Nine Mile II proteins modulate gene expression of monocytic host cells during infection. BMC Microbiol. 2010;10:244 pubmed publisher
    b>Coxiella burnetii is an intracellular bacterial pathogen that causes acute and chronic disease in humans...
  56. Limonard G, Nabuurs Franssen M, Weers Pothoff G, Wijkmans C, Besselink R, Horrevorts A, et al. One-year follow-up of patients of the ongoing Dutch Q fever outbreak: clinical, serological and echocardiographic findings. Infection. 2010;38:471-7 pubmed publisher
    ..Therefore, we report here the clinical outcome, serological follow-up and cardiac screening data of the Q fever patients of the current ongoing outbreak...
  57. Roest H, Ruuls R, Tilburg J, Nabuurs Franssen M, Klaassen C, Vellema P, et al. Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands. Emerg Infect Dis. 2011;17:668-75 pubmed publisher
    Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the ..
  58. Tilburg J, Rossen J, van Hannen E, Melchers W, Hermans M, van de Bovenkamp J, et al. Genotypic diversity of Coxiella burnetii in the 2007-2010 Q fever outbreak episodes in The Netherlands. J Clin Microbiol. 2012;50:1076-8 pubmed publisher
    The genotypic diversity of Coxiella burnetii in clinical samples obtained from the Dutch Q fever outbreak episodes of 2007-2010 was determined by using a 6-locus variable-number tandem repeat analysis panel...
  59. de Bruin A, van der Plaats R, De Heer L, Paauwe R, Schimmer B, Vellema P, et al. Detection of Coxiella burnetii DNA on small-ruminant farms during a Q fever outbreak in the Netherlands. Appl Environ Microbiol. 2012;78:1652-7 pubmed publisher
    ..The transmission of Coxiella burnetii to humans is thought to occur primarily via aerosols, although available data on C...
  60. Runge M, Binder A, Schotte U, Ganter M. Investigations concerning the prevalence of Coxiella burnetii and Chlamydia abortus in sheep in correlation with management systems and abortion rate in Lower Saxony in 2004. Berl Munch Tierarztl Wochenschr. 2012;125:138-43 pubmed
    ..However, three migrating flocks with a high intra-flock prevalence are localized in the southern parts of Lower Saxony. Spreading of C burnetii could occur, because of the large radius of grazing of all three flocks...
  61. Beare P. Genetic manipulation of Coxiella burnetii. Adv Exp Med Biol. 2012;984:249-71 pubmed publisher
    Until very recently, Coxiella burnetii was viewed and studied as an obligate intracellular bacterium that relied exclusively on a eucaryotic host cell for growth...
  62. van Schaik E, Chen C, Mertens K, Weber M, Samuel J. Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii. Nat Rev Microbiol. 2013;11:561-73 pubmed publisher
    The agent of Q fever, Coxiella burnetii, is an obligate intracellular bacterium that causes acute and chronic infections. The study of C...
  63. Rahimi E, Doosti A, Ameri M, Kabiri e, Sharifian B. Detection of Coxiella burnetii by nested PCR in bulk milk samples from dairy bovine, ovine, and caprine herds in Iran. Zoonoses Public Health. 2010;57:e38-41 pubmed publisher
    ..This study was conducted to determine the prevalence rate of Coxiella burnetii in bulk milk samples from dairy bovine, ovine, and caprine herds in Chaharmahal va Bakhtiari province, Iran...
  64. Samoilis G, Aivaliotis M, Vranakis I, Papadioti A, Tselentis Y, Tsiotis G, et al. Proteomic screening for possible effector molecules secreted by the obligate intracellular pathogen Coxiella burnetii. J Proteome Res. 2010;9:1619-26 pubmed publisher
    b>Coxiella burnetii is a Gram-negative, gamma-proteobacteria with nearly worldwide distribution, and it is the pathogenic agent of Q-fever in man...
  65. Morgan J, Luedtke B, Shaw E. Polar localization of the Coxiella burnetii type IVB secretion system. FEMS Microbiol Lett. 2010;305:177-83 pubmed publisher
    b>Coxiella burnetii is a Gram-negative pleomorphic bacterium and the causative agent of Q fever...
  66. Tilburg J, Nabuurs Franssen M, van Hannen E, Horrevorts A, Melchers W, Klaassen C. Contamination of commercial PCR master mix with DNA from Coxiella burnetii. J Clin Microbiol. 2010;48:4634-5 pubmed publisher
    ..It was established that this Master Mix contained DNA from Coxiella burnetii, probably as a result of the use of compounds of animal origin such as bovine serum albumin.
  67. Ryan E, Kirby M, Collins D, Sayers R, Mee J, Clegg T. Prevalence of Coxiella burnetii (Q fever) antibodies in bovine serum and bulk-milk samples. Epidemiol Infect. 2011;139:1413-7 pubmed publisher
    Q fever (Coxiella burnetii) is a zoonotic disease of increasing public health importance. The objective of this study was to estimate the prevalence of, and risk factors associated with, exposure to C...
  68. Guatteo R, Joly A, Beaudeau F. Shedding and serological patterns of dairy cows following abortions associated with Coxiella burnetii DNA detection. Vet Microbiol. 2012;155:430-3 pubmed publisher
    To describe both shedding and serological patterns following abortions detected as being associated with Coxiella burnetii (Cb), 24 cows experiencing an abortion due to Cb were followed over a one month period...
  69. Loftis A, Reeves W, Miller M, Massung R. Coxiella burnetii, the agent of Q fever, in domestic sheep flocks from Wyoming, United States. Vector Borne Zoonotic Dis. 2012;12:189-91 pubmed publisher
    b>Coxiella burnetii, the agent of Q fever, is an intracellular bacterial pathogen. It has a nearly cosmopolitan distribution. We conducted a serological survey of domestic sheep herds for infections with C...
  70. de Rooij M, Schimmer B, Versteeg B, Schneeberger P, Berends B, Heederik D, et al. Risk factors of Coxiella burnetii (Q fever) seropositivity in veterinary medicine students. PLoS ONE. 2012;7:e32108 pubmed publisher
    ..This study aimed to assess the seroprevalence of Coxiella burnetii among veterinary medicine students and to identify associated risk factors.
  71. Kampschreur L, Hagenaars J, Wielders C, Elsman P, Lestrade P, Koning O, et al. Screening for Coxiella burnetii seroprevalence in chronic Q fever high-risk groups reveals the magnitude of the Dutch Q fever outbreak. Epidemiol Infect. 2013;141:847-51 pubmed publisher
    ..Based on Q fever screening programmes, seroprevalence of IgG phase II antibodies to Coxiella burnetii in the JBH catchment area was 10·7% [785 tested, 84 seropositive, 95% confidence interval (CI) 8·5-12·9]...
  72. Maturana P, Graham J, Sharma U, Voth D. Refining the plasmid-encoded type IV secretion system substrate repertoire of Coxiella burnetii. J Bacteriol. 2013;195:3269-76 pubmed publisher
    The intracellular bacterial agent of Q fever, Coxiella burnetii, translocates effector proteins into its host cell cytosol via a Dot/Icm type IV secretion system (T4SS)...
  73. Roest H, Post J, van Gelderen B, van Zijderveld F, Rebel J. Q fever in pregnant goats: humoral and cellular immune responses. Vet Res. 2013;44:67 pubmed publisher
    Q fever is a zoonosis caused by the intracellular bacterium Coxiella burnetii. Both humoral and cellular immunity are important in the host defence against intracellular bacteria. Little is known about the immune response to C...
  74. Kersh G, Lambourn D, Self J, Akmajian A, Stanton J, Baszler T, et al. Coxiella burnetii infection of a Steller sea lion (Eumetopias jubatus) found in Washington State. J Clin Microbiol. 2010;48:3428-31 pubmed publisher
    ..sea lion stranded in the State of Washington was found to have placentitis caused by a unique strain of Coxiella burnetii. This is the first description of coxiellosis in a sea lion and suggests that exposure to sea lions may be a ..
  75. Siroký P, Kubelová M, Modry D, Erhart J, Literak I, Spitalska E, et al. Tortoise tick Hyalomma aegyptium as long term carrier of Q fever agent Coxiella burnetii--evidence from experimental infection. Parasitol Res. 2010;107:1515-20 pubmed publisher
    ..We tested the competence of H. aegyptium larvae to acquire Coxiella burnetii infection from mammals, serve as a C...
  76. Lührmann A, Nogueira C, Carey K, Roy C. Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proc Natl Acad Sci U S A. 2010;107:18997-9001 pubmed publisher
    b>Coxiella burnetii and Legionella pneumophila are evolutionarily related pathogens with different intracellular infection strategies. C. burnetii persists within and is transmitted by mammalian hosts, whereas, L...
  77. Hill J, Samuel J. Coxiella burnetii acid phosphatase inhibits the release of reactive oxygen intermediates in polymorphonuclear leukocytes. Infect Immun. 2011;79:414-20 pubmed publisher
    b>Coxiella burnetii, the etiological agent of Q fever, is a small, Gram-negative, obligate intracellular bacterium. Replication of C...
  78. Schimmer B, Notermans D, Harms M, Reimerink J, Bakker J, Schneeberger P, et al. Low seroprevalence of Q fever in The Netherlands prior to a series of large outbreaks. Epidemiol Infect. 2012;140:27-35 pubmed publisher
    ..We tested these sera for IgG phase-2 antibodies against Coxiella burnetii with an ELISA to estimate the seroprevalence and to identify determinants for seropositivity before the Q ..
  79. Vranakis I, De Bock P, Papadioti A, Samoilis G, Tselentis Y, Gevaert K, et al. Unraveling persistent host cell infection with Coxiella burnetii by quantitative proteomics. J Proteome Res. 2011;10:4241-51 pubmed publisher
    ..burnetii orchestrates a vast number of different bacterial and eukaryotic host cell processes to persist within its host...
  80. Dijkstra F, van der Hoek W, Wijers N, Schimmer B, Rietveld A, Wijkmans C, et al. The 2007–2010 Q fever epidemic in The Netherlands: characteristics of notified acute Q fever patients and the association with dairy goat farming. FEMS Immunol Med Microbiol. 2012;64:3-12 pubmed publisher
    ..5% in the meat-processing industry including abattoirs. Dairy goat farms with Coxiella burnetii-induced abortion waves were mainly located in the same area where human cases occurred...
  81. Bernard H, Brockmann S, Kleinkauf N, Klinc C, Wagner Wiening C, Stark K, et al. High seroprevalence of Coxiella burnetii antibodies in veterinarians associated with cattle obstetrics, Bavaria, 2009. Vector Borne Zoonotic Dis. 2012;12:552-7 pubmed publisher
    Q fever is a zoonosis caused by Coxiella burnetii. Infection can result in severe disease. However, little is known about the risk of infection in veterinarians...
  82. Barry A, Boucherit N, Mottola G, Vadovic P, Trouplin V, Soubeyran P, et al. Impaired stimulation of p38?-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes. Cell Host Microbe. 2012;12:751-63 pubmed publisher
    ..LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C...
  83. Newton H, McDonough J, Roy C. Effector protein translocation by the Coxiella burnetii Dot/Icm type IV secretion system requires endocytic maturation of the pathogen-occupied vacuole. PLoS ONE. 2013;8:e54566 pubmed publisher
    The human pathogen Coxiella burnetii encodes a type IV secretion system called Dot/Icm that is essential for intracellular replication. The Dot/Icm system delivers bacterial effector proteins into the host cytosol during infection...
  84. De Lange M, Schimmer B, Vellema P, Hautvast J, Schneeberger P, VAN Duijnhoven Y. Coxiella burnetii seroprevalence and risk factors in sheep farmers and farm residents in The Netherlands. Epidemiol Infect. 2014;142:1231-44 pubmed publisher
    In this study, Coxiella burnetii seroprevalence was assessed for dairy and non-dairy sheep farm residents in The Netherlands for 2009-2010. Risk factors for seropositivity were identified for non-dairy sheep farm residents...
  85. Berri M, Rekiki A, Boumedine K, Rodolakis A. Simultaneous differential detection of Chlamydophila abortus, Chlamydophila pecorum and Coxiella burnetii from aborted ruminant's clinical samples using multiplex PCR. BMC Microbiol. 2009;9:130 pubmed publisher
    ..abortus) and Coxiella burnetii (C. burnetii). Chlamydophila pecorum (Cp...
  86. Chang C, Lin P, Hou M, Lin C, Hung M, Wu T, et al. Identification of risk factors of Coxiella burnetii (Q fever) infection in veterinary-associated populations in southern Taiwan. Zoonoses Public Health. 2010;57:e95-101 pubmed publisher
    ..The purpose of this study was to determine the seroprevalence and risk factors of Coxiella burnetii infection in veterinary-associated populations in southern Taiwan...
  87. Morgan J, Luedtke B, Thompson H, Shaw E. Coxiella burnetii type IVB secretion system region I genes are expressed early during the infection of host cells. FEMS Microbiol Lett. 2010;311:61-9 pubmed publisher
    Analysis of the Coxiella burnetii RSA 493 (Nine Mile phase I strain) genome revealed ORFs with significant homology to the type IVB secretion system (T4BSS) of Legionella pneumophila...
  88. Jager M, Weers Pothoff G, Hermans M, Meekelenkamp J, Schellekens J, Renders N, et al. Evaluation of a diagnostic algorithm for acute Q fever in an outbreak setting. Clin Vaccine Immunol. 2011;18:963-8 pubmed publisher
    ..algorithm for acute Q fever with an enzyme-linked immunosorbent assay for immunoglobulin M antibodies to Coxiella burnetii phase II antigens (MII screen) as an initial step...
  89. Papadioti A, Markoutsa S, Vranakis I, Tselentis Y, Karas M, Psaroulaki A, et al. A proteomic approach to investigate the differential antigenic profile of two Coxiella burnetii strains. J Proteomics. 2011;74:1150-9 pubmed publisher
    Q fever is a widespread zoonosis caused by Coxiella burnetii, an obligate intracellular Gram-negative bacterium. Current diagnostics of Q fever is based on serological testing of patient serum. Biological distinction among C...