ribosomal proteins

Summary

Summary: Proteins found in ribosomes. They are believed to have a catalytic function in reconstituting biologically active ribosomal subunits.

Top Publications

  1. Hensley M, Gunasekera T, Easton J, Sigdel T, Sugarbaker S, Klingbeil L, et al. Characterization of Zn(II)-responsive ribosomal proteins YkgM and L31 in E. coli. J Inorg Biochem. 2012;111:164-72 pubmed publisher
    ..These results are discussed in light of Zn(II) starvation model that has been postulated for B. subtilis...
  2. Shi W, Zhang X, Jiang X, Yuan H, Lee J, Barry C, et al. Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science. 2011;333:1630-2 pubmed publisher
    ..Trans-translation is essential for freeing scarce ribosomes in nonreplicating organisms, and its inhibition may explain the ability of PZA to eradicate persisting organisms. ..
  3. Suzuki A, Kogo R, Kawahara K, Sasaki M, Nishio M, Maehama T, et al. A new PICTure of nucleolar stress. Cancer Sci. 2012;103:632-7 pubmed publisher
    ..In response to this stress, several nucleolar ribosomal proteins (RPs) translocate to the nucleoplasm and bind to MDM2...
  4. Kouba T, Dányi I, Gunišová S, Munzarová V, Vlčková V, Cuchalová L, et al. Small ribosomal protein RPS0 stimulates translation initiation by mediating 40S-binding of eIF3 via its direct contact with the eIF3a/TIF32 subunit. PLoS ONE. 2012;7:e40464 pubmed publisher
    ..Together we conclude that the interaction between the flexible RPS0A-CTT and the residues 200-400 of the a/TIF32-NTD significantly stimulates attachment of eIF3 and its associated eIFs to small ribosomal subunits in vivo. ..
  5. Clatterbuck Soper S, Dator R, Limbach P, Woodson S. In vivo X-ray footprinting of pre-30S ribosomes reveals chaperone-dependent remodeling of late assembly intermediates. Mol Cell. 2013;52:506-16 pubmed publisher
    ..Our results indicate that cellular factors delay specific RNA folding steps to ensure the quality of assembly...
  6. Jia Q, Zhang Q, Zhang Z, Wang Y, Zhang W, Zhou Y, et al. Transcriptome analysis of the zebrafish model of Diamond-Blackfan anemia from RPS19 deficiency via p53-dependent and -independent pathways. PLoS ONE. 2013;8:e71782 pubmed publisher
    ..It has been proven that defects of ribosomal proteins can lead to this disease and that RPS19 is the most frequently mutated gene in DBA patients...
  7. Provost E, Weier C, Leach S. Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Zebrafish. 2013;10:161-9 pubmed publisher
  8. Kapoor N, Ahuja R, Shukla S, Kumar V. The HBx protein of hepatitis B virus confers resistance against nucleolar stress and anti-cancer drug-induced p53 expression. FEBS Lett. 2013;587:1287-92 pubmed publisher
    ..Thus, HBx not only can facilitate cell proliferation under stress conditions but can confer resistance against anticancer drugs. ..
  9. Sugihara Y, Sadohara E, Yonezawa K, Kugo M, Oshima K, Matsuda T, et al. Identification and expression of an autosomal paralogue of ribosomal protein S4, X-linked, in mice: potential involvement of testis-specific ribosomal proteins in translation and spermatogenesis. Gene. 2013;521:91-9 pubmed publisher
    ..Our previous proteomic survey of rodent ribosomes found the testis-specific ribosomal proteins L10-like and L39-like, which are paralogues of the X-linked ribosomal proteins L10 and L39, respectively...

More Information

Publications79

  1. Filipovska A, Rackham O. Specialization from synthesis: how ribosome diversity can customize protein function. FEBS Lett. 2013;587:1189-97 pubmed publisher
  2. Falcone Ferreyra M, Casadevall R, Luciani M, Pezza A, Casati P. New evidence for differential roles of l10 ribosomal proteins from Arabidopsis. Plant Physiol. 2013;163:378-91 pubmed publisher
    ..Finally, the involvement of RPL10B and RPL10C in UV-B responses was analyzed by two-dimensional gels followed by mass spectrometry. Overall, our data provide new evidence about the nonredundant roles of RPL10 proteins in Arabidopsis. ..
  3. Kim Y, Kim H, Kim J. Cytoplasmic ribosomal protein S3 (rpS3) plays a pivotal role in mitochondrial DNA damage surveillance. Biochim Biophys Acta. 2013;1833:2943-2952 pubmed publisher
    ..Therefore, we concluded that when mitochondrial DNA damages accumulate due to increased levels of ROS, rpS3 accumulates in the mitochondria to repair damaged DNA due to the decreased interaction between rpS3 and HSP90 in the cytosol. ..
  4. Downey M, Knight B, Vashisht A, Seller C, Wohlschlegel J, Shore D, et al. Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol. 2013;23:1638-48 pubmed publisher
    ..We provide insights into how the action of histone acetylation machineries converges with nutrient-sensing pathways to regulate important aspects of cell growth. ..
  5. Lv J, Huang X, Klug J, Fröhlich S, Lacher P, Xu A, et al. Ribosomal protein S19 is a novel therapeutic agent in inflammatory kidney disease. Clin Sci (Lond). 2013;124:627-37 pubmed publisher
    ..01). These results demonstrate that RPS19 is a potent anti-inflammatory agent, which appears to work primarily by inhibiting MIF signalling. ..
  6. Baba K, Tumuraya K, Tanaka I, Yao M, Uchiumi T. Molecular dissection of the silkworm ribosomal stalk complex: the role of multiple copies of the stalk proteins. Nucleic Acids Res. 2013;41:3635-43 pubmed publisher
    ..This promotion of activity by two stalk dimers was lost upon mutation of the conserved YPT sequence connecting the two helices of P0, suggesting a role for this sequence in cooperativity of two stalk dimers. ..
  7. Zhang Y, Duc A, Rao S, Sun X, Bilbee A, Rhodes M, et al. Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Dev Cell. 2013;24:411-25 pubmed publisher
    ..Accordingly, circumstances that tip the balance of these paralogs in favor of Rpl22 (e.g., Rpl22l1 knockdown or Rpl22 overexpression) result in repression of Smad1 and blockade of HSC emergence...
  8. Kaushal P, Sharma M, Booth T, Haque E, Tung C, Sanbonmatsu K, et al. Cryo-EM structure of the small subunit of the mammalian mitochondrial ribosome. Proc Natl Acad Sci U S A. 2014;111:7284-9 pubmed publisher
    ..The mammalian 55S mitoribosome contains significantly smaller rRNAs and a large mass of mitochondrial ribosomal proteins (MRPs), including large mito-specific amino acid extensions and insertions in MRPs that are homologous to ..
  9. Leong V, Kent M, Jomaa A, Ortega J. Escherichia coli rimM and yjeQ null strains accumulate immature 30S subunits of similar structure and protein complement. RNA. 2013;19:789-802 pubmed publisher
    ..These 30S subunits were also partially depleted in all tertiary ribosomal proteins, particularly those binding in the head domain...
  10. Deiorio Haggar K, Anthony J, Meyer M. RNA structures regulating ribosomal protein biosynthesis in bacilli. RNA Biol. 2013;10:1180-4 pubmed publisher
  11. Fu Y, Deiorio Haggar K, Anthony J, Meyer M. Most RNAs regulating ribosomal protein biosynthesis in Escherichia coli are narrowly distributed to Gammaproteobacteria. Nucleic Acids Res. 2013;41:3491-503 pubmed publisher
    In Escherichia coli, 12 distinct RNA structures within the transcripts encoding ribosomal proteins interact with specific ribosomal proteins to allow autogenous regulation of expression from large multi-gene operons, thus coordinating ..
  12. Kimura Y, Irie K, Irie K. Pbp1 is involved in Ccr4- and Khd1-mediated regulation of cell growth through association with ribosomal proteins Rpl12a and Rpl12b. Eukaryot Cell. 2013;12:864-74 pubmed publisher
    ..We then screened novel Pbp1-interacting factors and found that Pbp1 interacts with ribosomal proteins Rpl12a and Rpl12b...
  13. Karbstein K. Quality control mechanisms during ribosome maturation. Trends Cell Biol. 2013;23:242-50 pubmed publisher
    ..Furthermore, haploinsufficiency of ribosomal proteins, which increases the chances of forming incompletely assembled ribosomes, can predispose to cancer...
  14. Ramírez L, Santos D, Souza A, Coelho E, Barral A, Alonso C, et al. Evaluation of immune responses and analysis of the effect of vaccination of the Leishmania major recombinant ribosomal proteins L3 or L5 in two different murine models of cutaneous leishmaniasis. Vaccine. 2013;31:1312-9 pubmed publisher
    ..Recombinant versions of the four ribosomal proteins from Leishmania major were recognized by sera from human and canine patients suffering different clinical ..
  15. Wong Y, Ng Y, Mak A, Sze K, Wong K, Shaw P. Maize ribosome-inactivating protein uses Lys158-lys161 to interact with ribosomal protein P2 and the strength of interaction is correlated to the biological activities. PLoS ONE. 2012;7:e49608 pubmed publisher
    ..and cytotoxicity to 293T cells respectively, implicating the strength of interaction between RIPs and ribosomal proteins is important for the biological activity of RIPs...
  16. Armache J, Anger A, Marquez V, Franckenberg S, Frohlich T, Villa E, et al. Promiscuous behaviour of archaeal ribosomal proteins: implications for eukaryotic ribosome evolution. Nucleic Acids Res. 2013;41:1284-93 pubmed publisher
    ..Examination of these structures reveals a surprising promiscuous behavior of archaeal ribosomal proteins: We observe intersubunit promiscuity of S24e and L8e (L7ae), the latter binding to the head of the small ..
  17. Zhang J, Bai D, Ma X, Guan J, Zheng X. hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14. Oncogene. 2014;33:246-54 pubmed publisher
    ..Mounting evidence has suggested that ribosomal proteins (RPs) modulate HDM2-p53 as a novel pathway for regulating p53 signaling...
  18. Nakayashiki T, Mori H. Genome-wide screening with hydroxyurea reveals a link between nonessential ribosomal proteins and reactive oxygen species production. J Bacteriol. 2013;195:1226-35 pubmed publisher
    ..based on COG categorization were the most enriched, and three of them were deletion mutants of nonessential ribosomal proteins (L1, L32, and L36)...
  19. Altvater M, Chang Y, Melnik A, Occhipinti L, Schütz S, Rothenbusch U, et al. Targeted proteomics reveals compositional dynamics of 60S pre-ribosomes after nuclear export. Mol Syst Biol. 2012;8:628 pubmed publisher
  20. De Keersmaecker K, Atak Z, Li N, Vicente C, Patchett S, Girardi T, et al. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat Genet. 2013;45:186-90 pubmed publisher
    ..In addition, we identify mutations affecting the ribosomal proteins RPL5 and RPL10 in 12 of 122 (9.8%) pediatric T-ALLs, with recurrent alterations of Arg98 in RPL10...
  21. Chen S, Williamson J. Characterization of the ribosome biogenesis landscape in E. coli using quantitative mass spectrometry. J Mol Biol. 2013;425:767-79 pubmed publisher
    ..These results represent new in vivo assembly maps of the E. coli 30S and 50S subunits, and the general qMS approach should prove to be a solid platform for future studies of ribosome biogenesis across a host of model organisms. ..
  22. Mayerle M, Woodson S. Specific contacts between protein S4 and ribosomal RNA are required at multiple stages of ribosome assembly. RNA. 2013;19:574-85 pubmed publisher
    ..Our results show that early S4-RNA interactions guide rRNA folding and impact late steps of 30S assembly. ..
  23. Stanborough T, Niederhauser J, Koch B, Bergler H, Pertschy B. Ribosomal protein S3 interacts with the NF-?B inhibitor I?B?. FEBS Lett. 2014;588:659-64 pubmed publisher
    ..Our results suggest that I?B? sequesters not only p65 but also RPS3 in the cytoplasm. This would ensure maintenance of an RPS3 pool for the NF-?B pathway as well as equimolar release of RPS3 and p65 upon stimulation. ..
  24. Woolford J, Baserga S. Ribosome biogenesis in the yeast Saccharomyces cerevisiae. Genetics. 2013;195:643-81 pubmed publisher
    ..pathways of folding, coupled with nucleotide modification, removal of spacer sequences, and binding to ribosomal proteins. More than 200 assembly factors and 76 small nucleolar RNAs transiently associate with assembling ribosomes, ..
  25. Ossareh Nazari B, Ni o C, Bengtson M, Lee J, Joazeiro C, Dargemont C. Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy. J Cell Biol. 2014;204:909-17 pubmed publisher
    ..Thus, Ltn1 and Ubp3-Bre5 likely contribute to adapt ribophagy activity to both nutrient supply and protein translation...
  26. Landowski M, O Donohue M, Buros C, Ghazvinian R, Montel Lehry N, Vlachos A, et al. Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. Hum Genet. 2013;132:1265-74 pubmed publisher
    ..These data identify RPL15 as a new gene involved in DBA and further support the presence of large deletions in RP genes in DBA patients. ..
  27. Thapa M, Bommakanti A, Shamsuzzaman M, Gregory B, Samsel L, Zengel J, et al. Repressed synthesis of ribosomal proteins generates protein-specific cell cycle and morphological phenotypes. Mol Biol Cell. 2013;24:3620-33 pubmed publisher
  28. Daftuar L, Zhu Y, Jacq X, Prives C. Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network. PLoS ONE. 2013;8:e68667 pubmed publisher
    ..to the nucleolus, the site of ribosome production, have long been linked to cancer, and mutations in several ribosomal proteins (RPs) have been associated with an increased risk for cancer in human diseases...
  29. Suarez S, Ferroni A, Lotz A, Jolley K, Guerin P, Leto J, et al. Ribosomal proteins as biomarkers for bacterial identification by mass spectrometry in the clinical microbiology laboratory. J Microbiol Methods. 2013;94:390-6 pubmed publisher
    ..of the available databases, the Andromas database, 10 of the 13 species-specific biomarkers correspond to ribosomal proteins. Remarkably, one biomarker, ribosomal protein L32, was subject to inter-strain variability...
  30. Li R, Li X, Sun L, Chen F, Liu Z, Gu Y, et al. Reduction of ribosome level triggers flocculation of fission yeast cells. Eukaryot Cell. 2013;12:450-9 pubmed publisher
    ..caused by deleting ribosomal protein genes in nonsexual flocculating cells was due to an imbalance between ribosomal proteins. We propose that once the reduction of ribosomal levels is below a certain threshold value, flocculation is ..
  31. Guo Q, Goto S, Chen Y, Feng B, Xu Y, Muto A, et al. Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process. Nucleic Acids Res. 2013;41:2609-20 pubmed publisher
    ..More importantly, this study reveals intriguing similarities and dissimilarities between the in vitro and the in vivo assembly pathways, suggesting that they are in general similar but with subtle differences. ..
  32. Gamalinda M, Jakovljevic J, Babiano R, Talkish J, de la Cruz J, Woolford J. Yeast polypeptide exit tunnel ribosomal proteins L17, L35 and L37 are necessary to recruit late-assembling factors required for 27SB pre-rRNA processing. Nucleic Acids Res. 2013;41:1965-83 pubmed publisher
    Ribosome synthesis involves the coordinated folding and processing of pre-rRNAs with assembly of ribosomal proteins. In eukaryotes, these events are facilitated by trans-acting factors that propel ribosome maturation from the nucleolus to ..
  33. Ohmayer U, Gamalinda M, Sauert M, Ossowski J, Pöll G, Linnemann J, et al. Studies on the assembly characteristics of large subunit ribosomal proteins in S. cerevisae. PLoS ONE. 2013;8:e68412 pubmed publisher
    ..the assembly process of ribosomal subunits, their structural components, the ribosomal RNAs (rRNAs) and the ribosomal proteins (r-proteins) have to join together in a highly dynamic and defined manner to enable the efficient formation ..
  34. Lim K, Kim K, Choi S, Park E, Park S, Ryu K, et al. RPS3a over-expressed in HBV-associated hepatocellular carcinoma enhances the HBx-induced NF-?B signaling via its novel chaperoning function. PLoS ONE. 2011;6:e22258 pubmed publisher
    ..The results suggest that RPS3a, via extra-ribosomal chaperoning function for HBx, contributes to virally induced oncogenesis by enhancing HBx-induced NF-?B signaling pathway. ..
  35. Wang L, Zhao Y, Liu Q, Huang Y, Hu C, Liao G. Improvement of A21978C production in Streptomyces roseosporus by reporter-guided rpsL mutation selection. J Appl Microbiol. 2012;112:1095-101 pubmed publisher
    ..The strategies presented here, which integrated the advantages of both ribosome engineering and reporter-guided mutation selection, could be applied to other bacteria to improve their yield of secondary metabolites. ..
  36. Talkish J, Zhang J, Jakovljevic J, Horsey E, Woolford J. Hierarchical recruitment into nascent ribosomes of assembly factors required for 27SB pre-rRNA processing in Saccharomyces cerevisiae. Nucleic Acids Res. 2012;40:8646-61 pubmed
    ..Inhibition of TOR kinase decreases association of Rpf2, Spb4, Nog1 and Nog2 with pre-ribosomes. ..
  37. Yutin N, Puigbò P, Koonin E, Wolf Y. Phylogenomics of prokaryotic ribosomal proteins. PLoS ONE. 2012;7:e36972 pubmed publisher
    ..These alignments, available for download, can be used as search profiles to improve genome annotation of r-proteins and for further comparative genomics studies. ..
  38. Keel S, Phelps S, Sabo K, O Leary M, Kirn Safran C, Abkowitz J. Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis. Exp Hematol. 2012;40:290-4 pubmed publisher
    ..Their common erythroid phenotype reflects a shared pathophysiology-haploinsufficiency of one of many ribosomal proteins and somatic deletion of one allele of the ribosomal protein S14 gene, respectively...
  39. Babiano R, Gamalinda M, Woolford J, de la Cruz J. Saccharomyces cerevisiae ribosomal protein L26 is not essential for ribosome assembly and function. Mol Cell Biol. 2012;32:3228-41 pubmed publisher
    b>Ribosomal proteins play important roles in ribosome biogenesis and function. Here, we study the evolutionarily conserved L26 in Saccharomyces cerevisiae, which assembles into pre-60S ribosomal particles in the nucle(ol)us...
  40. Bursac S, Brdovcak M, Pfannkuchen M, Orsolic I, Golomb L, Zhu Y, et al. Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proc Natl Acad Sci U S A. 2012;109:20467-72 pubmed publisher
    Impairment of ribosomal biogenesis can activate the p53 protein independently of DNA damage. The ability of ribosomal proteins L5, L11, L23, L26, or S7 to bind Mdm2 and inhibit its ubiquitin ligase activity has been suggested as a ..
  41. Zhou X, Hao Q, Liao J, Zhang Q, Lu H. Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress. Oncogene. 2013;32:388-96 pubmed publisher
    ..Several ribosomal proteins, such as RPL11, RPL5, RPL23, RPL26 or RPS7, have been shown to have a role in regulation of this feedback ..
  42. Li C, Ge M, Yin Y, Luo M, Chen D. Silencing expression of ribosomal protein L26 and L29 by RNA interfering inhibits proliferation of human pancreatic cancer PANC-1 cells. Mol Cell Biochem. 2012;370:127-39 pubmed publisher
    ..Human whole genome microarray was then used to compare the gene expression profile. As a result, ribosomal proteins L26 and L29 (RPL26 and RPL29) were dramatically upregulated by KRAS-shRNA specifically...
  43. Hauser R, Pech M, Kijek J, Yamamoto H, Titz B, Naeve F, et al. RsfA (YbeB) proteins are conserved ribosomal silencing factors. PLoS Genet. 2012;8:e1002815 pubmed publisher
    ..RsfA helps cells to adapt to slow-growth/stationary phase conditions by down-regulating protein synthesis, one of the most energy-consuming processes in both bacterial and eukaryotic cells. ..
  44. Hajnsdorf E, Boni I. Multiple activities of RNA-binding proteins S1 and Hfq. Biochimie. 2012;94:1544-53 pubmed publisher
    ..In bacteria, RNA-binding proteins may be specific for a few RNA targets (e.g., several ribosomal proteins that recognize both rRNA during ribosome assembly and their own mRNAs when acting as highly specific ..
  45. Williams D, Fournier G, Lapierre P, Swithers K, Green A, Andam C, et al. A rooted net of life. Biol Direct. 2011;6:45 pubmed publisher
    ..Given sufficient evidence, edges may then be differentiated as those representing vertical lines of inheritance within lineages and those representing horizontal genetic transfers or endosymbioses between lineages. ..
  46. Nomura N, Honda T, Baba K, Naganuma T, Tanzawa T, Arisaka F, et al. Archaeal ribosomal stalk protein interacts with translation factors in a nucleotide-independent manner via its conserved C terminus. Proc Natl Acad Sci U S A. 2012;109:3748-53 pubmed publisher
    ..This consistent binding ability of the stalk protein may contribute to maintaining high concentrations of translation factors around the ribosome, thus promoting translational efficiency. ..
  47. Provost E, Wehner K, Zhong X, Ashar F, Nguyen E, Green R, et al. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development. 2012;139:3232-41 pubmed publisher
    ..The pancreatic phenotypes observed in rpl3- and pes-deficient embryos were also independent of p53. Together, these data suggest novel p53-independent roles for ribosomal biogenesis genes in zebrafish pancreas development...
  48. Galmiche L, Serre V, Beinat M, Assouline Z, Lebre A, Chretien D, et al. Exome sequencing identifies MRPL3 mutation in mitochondrial cardiomyopathy. Hum Mutat. 2011;32:1225-31 pubmed publisher
    ..This observation gives support to the view that exome sequencing combined with genetic mapping is a powerful approach for the identification of new genes of mitochondrial disorders. ..
  49. Lacerda A, Dusi D, Alves E, Rodrigues J, Gomes A, Carneiro V. Expression analyses of Brachiaria brizantha genes encoding ribosomal proteins BbrizRPS8, BbrizRPS15a, and BbrizRPL41 during development of ovaries and anthers. Protoplasma. 2013;250:505-14 pubmed publisher
    ..brizantha plants (CL 09, CL10, and CL21) which show similarity in databases with genes encoding ribosomal proteins S8, S15a, and L41 and were named BbrizRPS8, BbrizRPS15a, and BbrizRPL41, respectively...
  50. Zhang X, Wang W, Wang H, Wang M, Xu W, Zhang R. Identification of ribosomal protein S25 (RPS25)-MDM2-p53 regulatory feedback loop. Oncogene. 2013;32:2782-91 pubmed publisher
    There is an increasing interest in determining the role of ribosomal proteins (RPs) in the regulation of MDM2-p53 pathway in coordinating cellular response to stress...
  51. Fumagalli S, Ivanenkov V, Teng T, Thomas G. Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint. Genes Dev. 2012;26:1028-40 pubmed publisher
    ..Induction of p53 is attributed to the binding and inhibition of human double minute 2 (Hdm2) by a subset of ribosomal proteins (RPs): RPS7, RPL5, RPL11, and RPL23...
  52. Ould Abeih M, Petit Topin I, Zidane N, Baron B, Bedouelle H. Multiple folding states and disorder of ribosomal protein SA, a membrane receptor for laminin, anticarcinogens, and pathogens. Biochemistry. 2012;51:4807-21 pubmed publisher
    ..RPSA includes an N-terminal domain, which is homologous to the prokaryotic ribosomal proteins S2, and a C-terminal extension, which is conserved in vertebrates...
  53. Horos R, Ijspeert H, Pospisilova D, Sendtner R, Andrieu Soler C, Taskesen E, et al. Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts. Blood. 2012;119:262-72 pubmed publisher
    ..Our data suggest that impaired internal ribosomal entry site-mediated translation of mRNAs expressed at increased levels in erythroblasts contributes to the erythroid phenotype of DBA. ..
  54. Ciganda M, Williams N. Eukaryotic 5S rRNA biogenesis. Wiley Interdiscip Rev RNA. 2011;2:523-33 pubmed publisher
    ..It is the only RNA species that binds ribosomal proteins prior to its assembly into the ribosome. Its transport into the nucleolus requires this interaction...
  55. McIntosh K, Bhattacharya A, Willis I, Warner J. Eukaryotic cells producing ribosomes deficient in Rpl1 are hypersensitive to defects in the ubiquitin-proteasome system. PLoS ONE. 2011;6:e23579 pubmed publisher
    ..Interestingly, in spite of rendering the cells hypersensitive to the proteasome inhibitor MG132, shortage of Rpl1 partially suppresses the stress-invoked temporary repression of ribosome synthesis caused by MG132...
  56. Jakob S, Ohmayer U, Neueder A, Hierlmeier T, Pérez Fernández J, Hochmuth E, et al. Interrelationships between yeast ribosomal protein assembly events and transient ribosome biogenesis factors interactions in early pre-ribosomes. PLoS ONE. 2012;7:e32552 pubmed publisher
    ..Most likely, concomitant with that initial contacts between ribosomal proteins (r-proteins) and ribosome precursors (pre-ribosomes) are established which are converted into robust ..
  57. Pham T, Gao X, Tsai K, Olsen R, Wan F, Hardwidge P. Functional differences and interactions between the Escherichia coli type III secretion system effectors NleH1 and NleH2. Infect Immun. 2012;80:2133-40 pubmed publisher
    ..Taken together, our data show that NleH1 and NleH2 have pronounced functional differences in their ability to alter host transcriptional responses to bacterial infection...
  58. Faza M, Chang Y, Occhipinti L, Kemmler S, Panse V. Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes. PLoS Genet. 2012;8:e1002915 pubmed publisher
    ..Mex67-Mtr2 could engage a regulatory crosstalk among the three major export pathways for optimal cellular growth and proliferation. ..
  59. Horiguchi G, Van Lijsebettens M, Candela H, Micol J, Tsukaya H. Ribosomes and translation in plant developmental control. Plant Sci. 2012;191-192:24-34 pubmed publisher
    ..Although this might be a sign of unequal roles of individual ribosomal proteins, it does not explain every ribosomal-protein-defective phenotype...
  60. Payne E, Virgilio M, Narla A, Sun H, Levine M, Paw B, et al. L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. Blood. 2012;120:2214-24 pubmed publisher
    Haploinsufficiency of ribosomal proteins (RPs) has been proposed to be the common basis for the anemia observed in Diamond-Blackfan anemia (DBA) and myelodysplastic syndrome with loss of chromosome 5q [del(5q) MDS]...
  61. Fernández Pévida A, Rodríguez Galán O, Díaz Quintana A, Kressler D, de la Cruz J. Yeast ribosomal protein L40 assembles late into precursor 60 S ribosomes and is required for their cytoplasmic maturation. J Biol Chem. 2012;287:38390-407 pubmed publisher
    Most ribosomal proteins play important roles in ribosome biogenesis and function. Here, we have examined the contribution of the essential ribosomal protein L40 in these processes in the yeast Saccharomyces cerevisiae...
  62. Korepanov A, Korobeinikova A, Shestakov S, Garber M, Gongadze G. Protein L5 is crucial for in vivo assembly of the bacterial 50S ribosomal subunit central protuberance. Nucleic Acids Res. 2012;40:9153-9 pubmed publisher
    ..At the same time, 5S rRNA is found in the cytoplasm in complex with ribosomal proteins L18 and L25 at quantities equal to the amount of ribosomes...
  63. Mochizuki M, Kitamyo M, Miyoshi T, Ito K, Uchiumi T. Analysis of chimeric ribosomal stalk complexes from eukaryotic and bacterial sources: structural features responsible for specificity of translation factors. Genes Cells. 2012;17:273-84 pubmed publisher
  64. Bee A, Brewer D, Beesley C, Dodson A, Forootan S, Dickinson T, et al. siRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer. PLoS ONE. 2011;6:e22672 pubmed publisher
  65. Munzarová V, Panek J, Gunisova S, Dányi I, Szamecz B, Valášek L. Translation reinitiation relies on the interaction between eIF3a/TIF32 and progressively folded cis-acting mRNA elements preceding short uORFs. PLoS Genet. 2011;7:e1002137 pubmed publisher
    ..The fact that it likewise operates in the eIF3a/TIF32-dependent manner strongly suggests that at least in yeasts the underlying mechanism of reinitiation on short uORFs is conserved. ..
  66. Gudipati R, Neil H, Feuerbach F, Malabat C, Jacquier A. The yeast RPL9B gene is regulated by modulation between two modes of transcription termination. EMBO J. 2012;31:2427-37 pubmed publisher
  67. Seong K, Jung S, Kim H, Kim H, Jung Y, Choi S, et al. Yeast ribosomal protein S3 possesses a ?-lyase activity on damaged DNA. FEBS Lett. 2012;586:356-61 pubmed publisher
    ..In addition, the repair enzyme activity of yeast Rps3p was confirmed by complementation in xth, nfo Escherichia coli cells in which the DNA repair process is defective. ..
  68. Li N, Zhao G, Chen T, Xue L, Ma L, Niu J, et al. Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis. Cell Death Dis. 2012;3:e283 pubmed publisher
    ..Thus, our data imply that p33ING1-CSIG axis functions as a novel pro-apoptotic regulator in response to DNA damage...
  69. Qu X, Lancaster L, Noller H, Bustamante C, Tinoco I. Ribosomal protein S1 unwinds double-stranded RNA in multiple steps. Proc Natl Acad Sci U S A. 2012;109:14458-63 pubmed publisher
    ..Unwinding by multiple small substeps is much less rate limited by thermal breathing than unwinding in a single step. Thus, a multistep scheme greatly expedites S1 unwinding of an RNA structure compared to a single-step mode. ..
  70. Rao S, Lee S, Gutierrez A, Perrigoue J, Thapa R, Tu Z, et al. Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood. 2012;120:3764-73 pubmed publisher
    ..Our finding that Rpl22 inactivation promotes transformation by inducing expression of Lin28B provides the first insight into the mechanistic basis by which mutations in Rpl22, and perhaps some other RP genes, increases cancer risk. ..