clusterin

Summary

Summary: A highly conserved heterodimeric glycoprotein that is differentially expressed during many severe physiological disturbance states such as CANCER; APOPTOSIS; and various NEUROLOGICAL DISORDERS. Clusterin is ubiquitously expressed and appears to function as a secreted MOLECULAR CHAPERONE.

Top Publications

  1. Burdon K, Sharma S, Hewitt A, McMellon A, Wang J, Mackey D, et al. Genetic analysis of the clusterin gene in pseudoexfoliation syndrome. Mol Vis. 2008;14:1727-36 pubmed
    ..The clusterin (CLU) gene has been proposed as a candidate because of the presence of clusterin protein in pseudoexfoliation ..
  2. Rizzi F, Caccamo A, Belloni L, Bettuzzi S. Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. J Cell Physiol. 2009;219:314-23 pubmed publisher
    The Clusterin (CLU) gene produces different forms of protein products, which vary in their biological properties and distribution within the cell. Both the extra- and intracellular CLU forms regulate cell proliferation and apoptosis...
  3. Serrano A, Redondo M, Tellez T, Castro Vega I, Roldan M, Mendez R, et al. Regulation of clusterin expression in human cancer via DNA methylation. Tumour Biol. 2009;30:286-91 pubmed publisher
    b>Clusterin has attracted much recent attention because of its association with tumorigenesis and the progression of human carcinomas...
  4. Chayka O, Corvetta D, Dews M, Caccamo A, Piotrowska I, Santilli G, et al. Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas. J Natl Cancer Inst. 2009;101:663-77 pubmed publisher
    b>Clusterin expression in various types of human cancers may be higher or lower than in normal tissue, and clusterin may promote or inhibit apoptosis, cell motility, and inflammation...
  5. Kususda Y, Miyake H, Gleave M, Fujisawa M. Clusterin inhibition using OGX-011 synergistically enhances antitumour activity of sorafenib in a human renal cell carcinoma model. Br J Cancer. 2012;106:1945-52 pubmed publisher
    ..of sorafenib could be enhanced by combining with OGX-011, an antisense oligodeoxynucleotide (ODN) targeting clusterin, in renal cell carcinoma (RCC)...
  6. Bettuzzi S, Davalli P, Davoli S, Chayka O, Rizzi F, Belloni L, et al. Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread. Oncogene. 2009;28:4344-52 pubmed publisher
    ApoJ/Clusterin (CLU) is a heterodimeric protein localized in the nucleus, cytoplasm or secretory organelles and involved in cell survival and neoplastic transformation. Its function in human cancer is still highly controversial...
  7. Leskov K, Araki S, Lavik J, Gomez J, Gama V, Gonos E, et al. CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. J Biol Chem. 2011;286:40083-90 pubmed publisher
    Expression of the clusterin (CLU) gene results in the synthesis of a conventional secretory isoform set (pre- and mature secretory clusterin proteins, psCLU/sCLU), as well as another set of intracellular isoforms, appearing in the ..
  8. Carrasquillo M, Belbin O, Hunter T, Ma L, Bisceglio G, Zou F, et al. Replication of CLU, CR1, and PICALM associations with alzheimer disease. Arch Neurol. 2010;67:961-4 pubmed publisher
    ..These results show near-perfect replication and provide the first additional evidence that CLU, CR1, and PICALM are associated with the risk of LOAD. ..
  9. Blumenstein B, Saad F, Hotte S, Chi K, Eigl B, Gleave M, et al. Reduction in serum clusterin is a potential therapeutic biomarker in patients with castration-resistant prostate cancer treated with custirsen. Cancer Med. 2013;2:468-77 pubmed publisher
    Elevated levels of clusterin (CLU), a stress-induced and secreted cytoprotective chaperone, are associated with advanced tumor stage, metastasis, treatment resistance, and adverse outcome in several cancers...
  10. Yu H, Kuo H, Huang E, Liang C, Hwang K, Lin I, et al. Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease. Pediatr Cardiol. 2010;31:1151-6 pubmed publisher
    ..A unique proteomic profiling with increased or decreased fibrinogen, alpha-1-antitrypsin, clusterin, and immunoglobulin free light chains were noted in KD in our previous study...

Detail Information

Publications62

  1. Burdon K, Sharma S, Hewitt A, McMellon A, Wang J, Mackey D, et al. Genetic analysis of the clusterin gene in pseudoexfoliation syndrome. Mol Vis. 2008;14:1727-36 pubmed
    ..The clusterin (CLU) gene has been proposed as a candidate because of the presence of clusterin protein in pseudoexfoliation ..
  2. Rizzi F, Caccamo A, Belloni L, Bettuzzi S. Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells. J Cell Physiol. 2009;219:314-23 pubmed publisher
    The Clusterin (CLU) gene produces different forms of protein products, which vary in their biological properties and distribution within the cell. Both the extra- and intracellular CLU forms regulate cell proliferation and apoptosis...
  3. Serrano A, Redondo M, Tellez T, Castro Vega I, Roldan M, Mendez R, et al. Regulation of clusterin expression in human cancer via DNA methylation. Tumour Biol. 2009;30:286-91 pubmed publisher
    b>Clusterin has attracted much recent attention because of its association with tumorigenesis and the progression of human carcinomas...
  4. Chayka O, Corvetta D, Dews M, Caccamo A, Piotrowska I, Santilli G, et al. Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas. J Natl Cancer Inst. 2009;101:663-77 pubmed publisher
    b>Clusterin expression in various types of human cancers may be higher or lower than in normal tissue, and clusterin may promote or inhibit apoptosis, cell motility, and inflammation...
  5. Kususda Y, Miyake H, Gleave M, Fujisawa M. Clusterin inhibition using OGX-011 synergistically enhances antitumour activity of sorafenib in a human renal cell carcinoma model. Br J Cancer. 2012;106:1945-52 pubmed publisher
    ..of sorafenib could be enhanced by combining with OGX-011, an antisense oligodeoxynucleotide (ODN) targeting clusterin, in renal cell carcinoma (RCC)...
  6. Bettuzzi S, Davalli P, Davoli S, Chayka O, Rizzi F, Belloni L, et al. Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread. Oncogene. 2009;28:4344-52 pubmed publisher
    ApoJ/Clusterin (CLU) is a heterodimeric protein localized in the nucleus, cytoplasm or secretory organelles and involved in cell survival and neoplastic transformation. Its function in human cancer is still highly controversial...
  7. Leskov K, Araki S, Lavik J, Gomez J, Gama V, Gonos E, et al. CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. J Biol Chem. 2011;286:40083-90 pubmed publisher
    Expression of the clusterin (CLU) gene results in the synthesis of a conventional secretory isoform set (pre- and mature secretory clusterin proteins, psCLU/sCLU), as well as another set of intracellular isoforms, appearing in the ..
  8. Carrasquillo M, Belbin O, Hunter T, Ma L, Bisceglio G, Zou F, et al. Replication of CLU, CR1, and PICALM associations with alzheimer disease. Arch Neurol. 2010;67:961-4 pubmed publisher
    ..These results show near-perfect replication and provide the first additional evidence that CLU, CR1, and PICALM are associated with the risk of LOAD. ..
  9. Blumenstein B, Saad F, Hotte S, Chi K, Eigl B, Gleave M, et al. Reduction in serum clusterin is a potential therapeutic biomarker in patients with castration-resistant prostate cancer treated with custirsen. Cancer Med. 2013;2:468-77 pubmed publisher
    Elevated levels of clusterin (CLU), a stress-induced and secreted cytoprotective chaperone, are associated with advanced tumor stage, metastasis, treatment resistance, and adverse outcome in several cancers...
  10. Yu H, Kuo H, Huang E, Liang C, Hwang K, Lin I, et al. Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease. Pediatr Cardiol. 2010;31:1151-6 pubmed publisher
    ..A unique proteomic profiling with increased or decreased fibrinogen, alpha-1-antitrypsin, clusterin, and immunoglobulin free light chains were noted in KD in our previous study...
  11. Sonn C, Yu Y, Hong Y, Shim Y, Bluestone J, Min B, et al. Clusterin synergizes with IL-2 for the expansion and IFN-? production of natural killer cells. J Leukoc Biol. 2010;88:955-63 pubmed publisher
    ..Therefore, the role of CLU on NK cells should be taken into consideration for the previously observed, diverse functions of CLU in chronic inflammatory and autoimmune conditions...
  12. Okada N, Kawakita T, Mishima K, Saito I, Miyashita H, Yoshida S, et al. Clusterin promotes corneal epithelial cell growth through upregulation of hepatocyte growth factor by mesenchymal cells in vitro. Invest Ophthalmol Vis Sci. 2011;52:2905-10 pubmed publisher
    Although the cornea expresses high levels of clusterin (CLU), the role of CLU in the cornea is poorly understood. This study was performed to investigate the possible role of CLU in corneal epithelial homeostasis...
  13. Polimeno L, Pesetti B, Annoscia E, Giorgio F, Francavilla R, Lisowsky T, et al. Alrp, a survival factor that controls the apoptotic process of regenerating liver after partial hepatectomy in rats. Free Radic Res. 2011;45:534-49 pubmed publisher
  14. Cheng C, Cherng S, Wu W, Yang T, Huang X, Liao F, et al. Regulation of chemosensitivity and migration by clusterin in non-small cell lung cancer cells. Cancer Chemother Pharmacol. 2012;69:145-54 pubmed publisher
    In terms of drug resistance, cancer cells usually benefit from high clusterin (CLU) expression on chemotherapy. In contrast, CLU expression has been found to be a favorable prognostic factor in lung cancer patients...
  15. Hassan M, Watari H, Christenson L, Bettuzzi S, Sakuragi N. Intracellular clusterin negatively regulates ovarian chemoresistance: compromised expression sensitizes ovarian cancer cells to paclitaxel. Tumour Biol. 2011;32:1031-47 pubmed publisher
    ..Previously, results from our lab revealed that secretory clusterin (CLU) form positively mediates TX response in ovarian cancer cells...
  16. Narayan P, Orte A, Clarke R, Bolognesi B, HOOK S, Ganzinger K, et al. The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-?(1-40) peptide. Nat Struct Mol Biol. 2011;19:79-83 pubmed publisher
    In recent genome-wide association studies, the extracellular chaperone protein, clusterin, has been identified as a newly-discovered risk factor in Alzheimer's disease...
  17. Baig S, Palmer L, Owen M, Williams J, Kehoe P, Love S. Clusterin mRNA and protein in Alzheimer's disease. J Alzheimers Dis. 2012;28:337-44 pubmed publisher
    b>Clusterin, a multifunctional lipoprotein is expressed in a number of tissues but expression is particularly high in the brain, where it binds to amyloid-? (A?), possibly facilitating A? transport into the bloodstream...
  18. Lu J, Luo J, Pang J, Cao J, Wu R, Tong Z, et al. Lentivirus-mediated RNA interference of clusterin enhances the chemosensitivity of EJ bladder cancer cells to epirubicin in vitro. Mol Med Rep. 2012;6:1133-9 pubmed publisher
    b>Clusterin (CLU) is a glycoprotein that is over-expressed in a number of malignant tumors and has been proven to correlate closely with the chemoresistance of several cancer cells to chemotherapeutic agents...
  19. Howlett D, Hortobagyi T, Francis P. Clusterin associates specifically with A?40 in Alzheimer's disease brain tissue. Brain Pathol. 2013;23:623-32 pubmed publisher
    Genome-wide association studies have pointed to clusterin (apolipoprotein J) as being linked to the occurrence of Alzheimer's disease (AD); studies have identified the protein as a possible biomarker...
  20. Matsumoto H, Yamamoto Y, Shiota M, Kuruma H, Beraldi E, Matsuyama H, et al. Cotargeting Androgen Receptor and Clusterin Delays Castrate-Resistant Prostate Cancer Progression by Inhibiting Adaptive Stress Response and AR Stability. Cancer Res. 2013;73:5206-17 pubmed publisher
    ..resistance rapidly develops and is often associated with increased stress-activated molecular chaperones like clusterin (CLU) and continued AR signaling...
  21. Xu F, Karnaukhova E, Vostal J. Human cellular prion protein interacts directly with clusterin protein. Biochim Biophys Acta. 2008;1782:615-20 pubmed publisher
    ..Using the yeast two-hybrid assay we identified an interaction between prion protein and clusterin, a chaperone glycoprotein...
  22. Zhou W, Guan Q, Kwan C, Chen H, Gleave M, Nguan C, et al. Loss of clusterin expression worsens renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2010;298:F568-78 pubmed publisher
    ..b>Clusterin, a secreted glycoprotein, is an antiapoptotic protein in cancer cells...
  23. Bettuzzi S, Rizzi F. Chapter 5: Nuclear CLU (nCLU) and the fate of the cell. Adv Cancer Res. 2009;104:59-88 pubmed publisher
    The possible biological role played by Clusterin (CLU) has been puzzling researchers for a long time since its first discovery and characterization...
  24. Falgarone G, Chiocchia G. Chapter 8: Clusterin: A multifacet protein at the crossroad of inflammation and autoimmunity. Adv Cancer Res. 2009;104:139-70 pubmed publisher
    For years, clusterin has been recognized as a secreted protein and a large number of works demonstrated that this ubiquitously expressed protein has multiple activities...
  25. Kevans D, Foley J, Tenniswood M, Sheahan K, Hyland J, O Donoghue D, et al. High clusterin expression correlates with a poor outcome in stage II colorectal cancers. Cancer Epidemiol Biomarkers Prev. 2009;18:393-9 pubmed publisher
    The role of clusterin in tumor growth and progression remains unclear...
  26. Tousi F, Bones J, Iliopoulos O, Hancock W, Hincapie M. Multidimensional liquid chromatography platform for profiling alterations of clusterin N-glycosylation in the plasma of patients with renal cell carcinoma. J Chromatogr A. 2012;1256:121-8 pubmed publisher
    ..b>Clusterin (Apolipoprotein J) has been implicated in renal cell carcinoma (RCC) and other types of malignancy as potential ..
  27. Wang Y, Wang X, Zhao H, Liang B, Du Q. Clusterin confers resistance to TNF-alpha-induced apoptosis in breast cancer cells through NF-kappaB activation and Bcl-2 overexpression. J Chemother. 2012;24:348-57 pubmed publisher
    Secretory clusterin (sClu) is an anti-apoptotic protein that plays a role in protecting cells from Tumour-necrosis factor (TNF)-alpha-induced apoptosis...
  28. Miyake H, Muramaki M, Furukawa J, Kurahashi T, Fujisawa M. Serum level of clusterin and its density in men with prostate cancer as novel biomarkers reflecting disease extension. Urology. 2010;75:454-9 pubmed publisher
    To assess whether the serum level of clusterin and its density could be used as novel biomarkers of prostate cancer. Sera were obtained from 380 patients with prostate cancer and 120 with benign prostatic hyperplasia...
  29. Materia S, Cater M, Klomp L, Mercer J, La Fontaine S. Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. J Biol Chem. 2012;287:2485-99 pubmed publisher
    ..b>Clusterin and COMMD1 were previously identified as interacting partners of these Cu-ATPases...
  30. Kauwe J, Cruchaga C, Karch C, Sadler B, Lee M, Mayo K, et al. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. PLoS ONE. 2011;6:e15918 pubmed publisher
    ..Our results suggest that these variants do not affect risk via a mechanism that results in a strong additive effect on CSF levels of A?(42) or ptau(181). ..
  31. Schjeide B, Schnack C, Lambert J, Lill C, Kirchheiner J, Tumani H, et al. The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Arch Gen Psychiatry. 2011;68:207-13 pubmed publisher
    Two recent and simultaneously published genome-wide association studies independently implicated clusterin (CLU), complement receptor 1 (CR1), and phosphatidylinositol binding clathrin assembly protein (PICALM) as putative novel ..
  32. Panico F, Rizzi F, Fabbri L, Bettuzzi S, Luppi F. Clusterin (CLU) and lung cancer. Adv Cancer Res. 2009;105:63-76 pubmed publisher
    ..Several in vitro studies have examined the role of Clusterin (CLU) in carcinogenesis, lung cancer progression, and response to chemo- and radiotherapy...
  33. Jun H, Kim D, Lee S, Lee H, Seo J, Kim J, et al. Clusterin protects H9c2 cardiomyocytes from oxidative stress-induced apoptosis via Akt/GSK-3? signaling pathway. Exp Mol Med. 2011;43:53-61 pubmed
    b>Clusterin is a secretory glycoprotein, which is highly up-regulated in a variety of normal and injury tissues undergoing apoptosis including infarct region of the myocardium...
  34. Ekici S, Eroğlu A, Doğan Ekici A, Turkeri L. Clusterin immunoreactivity as a predictive factor for progression of non-muscle-invasive bladder carcinoma. Urol Int. 2011;86:31-5 pubmed publisher
    ..We analyzed the association of clusterin (CLU) with clinicopathological factors...
  35. Charnay Y, Imhof A, Vallet P, Kovari E, Bouras C, Giannakopoulos P. Clusterin in neurological disorders: molecular perspectives and clinical relevance. Brain Res Bull. 2012;88:434-43 pubmed publisher
    Firstly discovered in rete testis fluid, clusterin is a glycoprotein present in most of the other biological fluids. Several isoforms of clusterin are encoded from a single gene located on chromosome 8 in human species...
  36. Cohen L, Azriel Tamir H, Arotsker N, Sekler I, Hershfinkel M. Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin. PLoS ONE. 2012;7:e35482 pubmed publisher
    ..ZnR/GPR39 activation however, increased the expression of the anti-apoptotic protein clusterin in butyrate-treated cells...
  37. Mishima K, Inoue H, Nishiyama T, Mabuchi Y, Amano Y, Ide F, et al. Transplantation of side population cells restores the function of damaged exocrine glands through clusterin. Stem Cells. 2012;30:1925-37 pubmed publisher
    ..In addition, we clarified that endothelial cell-derived clusterin, a secretory protein, was an essential factor for SP cell-mediated recovery of the hypofunctioning glands ..
  38. Jeong S, Ledee D, Gordon G, Itakura T, Patel N, Martin A, et al. Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation. Am J Pathol. 2012;180:2028-39 pubmed publisher
    ..presented here show that the anti-inflammatory, cytoprotective intracellular and extracellular chaperone protein clusterin (CLU) interacts with MMP-9 both inside and outside epithelial cells...
  39. Xue H, Wong H. Targeting megalin to enhance delivery of anti-clusterin small-interfering RNA nanomedicine to chemo-treated breast cancer. Eur J Pharm Biopharm. 2012;81:24-32 pubmed publisher
    ..difficult to treat because they often develop drug resistance by upregulation of chemoresistant factors such as clusterin and should be preferably eradicated before they further spread out...
  40. Nuutinen T, Suuronen T, Kauppinen A, Salminen A. Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease. Neurosci Lett. 2010;475:64-8 pubmed publisher
    b>Clusterin is a secreted molecular chaperone, also called apolipoprotein J. Recent genetic studies have demonstrated that clusterin is a significant susceptibility gene for late-onset Alzheimer's disease (AD)...
  41. Zhou Y, Li L, Hu L, Peng T. Golgi phosphoprotein 2 (GOLPH2/GP73/GOLM1) interacts with secretory clusterin. Mol Biol Rep. 2011;38:1457-62 pubmed publisher
    ..Using secretory GOLPH2 (sGOLPH2, amino acid residues 55-401) as bait, secretory clusterin (sCLU) was identified as one interacting candidate by yeast two-hybrid screening, and the coiled-coil domain of ..
  42. Carter C. APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle. Neurosci Lett. 2010;483:96-100 pubmed publisher
    The major Alzheimer's disease susceptibility genes (APOE, clusterin, complement receptor 1 (CR1) and phosphatidylinositol binding clathrin assembly protein, PICALM) can be implicated directly (APOE, CR1) or indirectly (clusterin and ..
  43. Trougakos I, Gonos E. Chapter 9: Oxidative stress in malignant progression: The role of Clusterin, a sensitive cellular biosensor of free radicals. Adv Cancer Res. 2009;104:171-210 pubmed publisher
    b>Clusterin/Apolipoprotein J (CLU) gene is expressed in most human tissues and encodes for two protein isoforms; a conventional heterodimeric secreted glycoprotein and a truncated nuclear form...
  44. Chen Q, Wang Z, Zhang K, Liu X, Cao W, Zhang L, et al. Clusterin confers gemcitabine resistance in pancreatic cancer. World J Surg Oncol. 2011;9:59 pubmed publisher
    To measure clusterin expression in pancreatic cancer tissues and cell lines and to evaluate whether clusterin confers resistance to gmcitabine in pancreatic cancer cells...
  45. Kim N, Yoo J, Han J, Hwang E, Kim Y, Jeong E, et al. Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. J Cell Physiol. 2012;227:1157-67 pubmed publisher
    b>Clusterin (CLU), a glycoprotein, is involved in apoptosis, producing two alternatively spliced isoforms in various cell types...
  46. Jurkunas U, Bitar M, Rawe I. Colocalization of increased transforming growth factor-beta-induced protein (TGFBIp) and Clusterin in Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2009;50:1129-36 pubmed publisher
    ..differential expression of TGFBIp in normal human and Fuchs endothelial corneal dystrophy (FECD) endothelial cell-Descemet's membrane (HCEC-DM) complex, and to asses the structural role of TGFBIp and clusterin (CLU) in guttae formation.
  47. Shin J, Han K, Kang M, Kim Y, Park J, Choi W, et al. Expression of clusterin in normal and preeclamptic placentas. J Obstet Gynaecol Res. 2008;34:473-9 pubmed
    b>Clusterin is a multifunctional protein that is up-regulated during many different pathophysiological states...
  48. Essabbani A, Garcia L, Zonetti M, Fisco T, Pucci S, Chiocchia G. Exon-skipping strategy by ratio modulation between cytoprotective versus pro-apoptotic clusterin forms increased sensitivity of LNCaP to cell death. PLoS ONE. 2013;8:e54920 pubmed publisher
    In prostate cancer the secreted form of clusterin (sCLU) has been described as an anti-apoptotic protein whose expression is increased after therapeutic intervention, whereas, the nuclear protein form nCLU was reported to have pro-..
  49. Yan Y, Luo K, Zhang H, Chai W. RNA interference-mediated secretory clusterin gene silencing inhibits proliferation and promotes apoptosis of human non-small cell lung cancer cells. Hepatogastroenterology. 2013;60:70-5 pubmed
    ..Secretory clusterin (sCLU) is found in diverse types of human cancers and is unregulated in a variety of cell lines in response to ..
  50. Radziwon Balicka A, Santos Martinez M, Corbalan J, O Sullivan S, Treumann A, Gilmer J, et al. Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway. Carcinogenesis. 2014;35:324-32 pubmed publisher
    ..SILAC experiments demonstrated that thrombospondin 1 (TSP1) was released mainly from platelets and clusterin by both platelets and cancer cells...
  51. Xiu P, Dong X, Dong X, Xu Z, Zhu H, Liu F, et al. Secretory clusterin contributes to oxaliplatin resistance by activating Akt pathway in hepatocellular carcinoma. Cancer Sci. 2013;104:375-82 pubmed publisher
    Secretory clusterin (sCLU) is expressed in numerous cancers and is associated with the resistance to chemotherapy...
  52. Hassan M, Watari H, Han Y, Mitamura T, Hosaka M, Wang L, et al. Clusterin is a potential molecular predictor for ovarian cancer patient's survival: targeting clusterin improves response to paclitaxel. J Exp Clin Cancer Res. 2011;30:113 pubmed publisher
    b>Clusterin is a cytoprotective chaperone protein involved in numerous physiological processes, carcinogenesis, tumor growth and tissue remodelling...
  53. Muramaki M, So A, Hayashi N, Sowery R, Miyake H, Fujisawa M, et al. Chemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterin. BJU Int. 2009;103:384-90 pubmed publisher
    To characterize changes in clusterin (sCLU-2) expression in bladder cancer cells after continuous treatment with gemcitabine and to determine whether knockdown of sCLU-2 can re-introduce sensitivity of gemcitabine-resistant cells to ..
  54. Elias Sonnenschein L, Bertram L, Visser P. Relationship between genetic risk factors and markers for Alzheimer's disease pathology. Biomark Med. 2012;6:477-95 pubmed publisher
    ..Of all covered genes, only APOE and PICALM showed consistent effects on A? but not on tau, while no obvious effects were observed for CLU, CR1, ACE, SORL and MAPT. ..
  55. Pucci S, Bonanno E, Sesti F, Mazzarelli P, Mauriello A, Ricci F, et al. Clusterin in stool: a new biomarker for colon cancer screening?. Am J Gastroenterol. 2009;104:2807-15 pubmed publisher
    The identification of useful markers for early diagnosis of human colon cancer is a major goal still in progress. Clusterin is a pleiotropic protein with a broad range of functions...
  56. Zoubeidi A, Gleave M. Small heat shock proteins in cancer therapy and prognosis. Int J Biochem Cell Biol. 2012;44:1646-56 pubmed publisher
    Hsp27 and clusterin (CLU are stress-activated small heat shock proteins that are up-regulated in many cancers where they play important roles in stress-induced protein homeostasis (proteostasis), inhibition of cell death pathways, and ..
  57. Ling I, Bhongsatiern J, Simpson J, Fardo D, Estus S. Genetics of clusterin isoform expression and Alzheimer's disease risk. PLoS ONE. 2012;7:e33923 pubmed publisher
    ..and secreted proteins, respectively, we compared their expression; for both CLU1 and CLU2 transfected cells, clusterin is present in the secretory pathway, accumulates in the extracellular media, and is similar in size to clusterin ..
  58. ter Weeme M, Vonk A, Kupreishvili K, van Ham M, Zeerleder S, Wouters D, et al. Activated complement is more extensively present in diseased aortic valves than naturally occurring complement inhibitors: a sign of ongoing inflammation. Eur J Clin Invest. 2010;40:4-10 pubmed publisher
    ..for the presence of activated complement (C3d and C5b9) and the complement inhibitors C1-inh and clusterin. Areas of positivity were then quantified...
  59. De Flora S, Micale R, La Maestra S, Izzotti A, D Agostini F, Camoirano A, et al. Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A-treated rats and formation of DNA adducts in cultured human prostatic cells. Toxicol Sci. 2011;122:45-51 pubmed publisher
    ..BPA upregulated clusterin expression in atrophic prostate epithelial cells and induced lipid peroxidation and DNA fragmentation in ..
  60. Rizzi F, Bettuzzi S. The clusterin paradigm in prostate and breast carcinogenesis. Endocr Relat Cancer. 2010;17:R1-17 pubmed publisher
    The biological functions of clusterin (CLU, also known as ApoJ, SGP2, TRPM-2, CLI) have been puzzling the researchers since its first discovery in the early 80's...
  61. Shirasawa T, Miyata M, Eto H, Hamada N, Akasaki Y, Miyauchi T, et al. Deficiency of clusterin inhibits neointimal hyperplasia after vascular injury. J Atheroscler Thromb. 2009;16:772-81 pubmed
    Increased clusterin mRNA and protein levels have been detected in various tissues undergoing stress, and we previously reported that clusterin is markedly induced in media and neointima following vascular injury...
  62. Watari H, Kanuma T, Ohta Y, Hassan M, Mitamura T, Hosaka M, et al. Clusterin expression inversely correlates with chemosensitivity and predicts poor survival in patients with locally advanced cervical cancer treated with cisplatin-based neoadjuvant chemotherapy and radical hysterectomy. Pathol Oncol Res. 2010;16:345-52 pubmed publisher
    Overexpression of clusterin, an antiapoptotic molecule, has been reported to induce resistance to chemotherapy in a variety of cancer cell types...