anion transport proteins

Summary

Summary: Membrane proteins whose primary function is to facilitate the transport of negatively charged molecules (anions) across a biological membrane.

Top Publications

  1. Jansen I, Mardones P, Lecanda F, de Vries T, Recalde S, Hoeben K, et al. Ae2(a,b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria. FASEB J. 2009;23:3470-81 pubmed publisher
    ..Possibly, this might compensate for the absence of Ae2 in calvaria osteoclasts of Ae2(a,b)(-/-) mice. ..
  2. Kiba T, Feria Bourrellier A, Lafouge F, Lezhneva L, Boutet Mercey S, Orsel M, et al. The Arabidopsis nitrate transporter NRT2.4 plays a double role in roots and shoots of nitrogen-starved plants. Plant Cell. 2012;24:245-58 pubmed publisher
    ..4 (triple mutants) has an impact on biomass production under low nitrate supply. Together, our results demonstrate that NRT2.4 is a nitrate transporter that has a role in both roots and shoots under N starvation. ..
  3. Kechid M, Desbrosses G, Rokhsi W, Varoquaux F, Djekoun A, Touraine B. The NRT2.5 and NRT2.6 genes are involved in growth promotion of Arabidopsis by the plant growth-promoting rhizobacterium (PGPR) strain Phyllobacterium brassicacearum STM196. New Phytol. 2013;198:514-24 pubmed publisher
    ..Our findings demonstrate that NRT2.5 and NRT2.6, which are preferentially expressed in leaves, play an essential role in plant growth promotion by the rhizospheric bacterium STM196. ..
  4. Tang J, Pecka J, Tan X, Beisel K, He D. Engineered pendrin protein, an anion transporter and molecular motor. J Biol Chem. 2011;286:31014-21 pubmed publisher
    ..Thus, the engineered pendrin was capable of both transporting anions and generating force. ..
  5. Li Y, Liu Z, Shi P, Zhang J. The hearing gene Prestin unites echolocating bats and whales. Curr Biol. 2010;20:R55-6 pubmed publisher
  6. Zuber H, Davidian J, Wirtz M, Hell R, Belghazi M, Thompson R, et al. Sultr4;1 mutant seeds of Arabidopsis have an enhanced sulphate content and modified proteome suggesting metabolic adaptations to altered sulphate compartmentalization. BMC Plant Biol. 2010;10:78 pubmed publisher
    ..The low-affinity sulphate transporters SULTR4;1 and SULTR4;2 have been localized to the vacuolar membrane, where they may facilitate sulphate efflux from the vacuole...
  7. Wagner C, Mohebbi N, Uhlig U, Giebisch G, Breton S, Brown D, et al. Angiotensin II stimulates H?-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts. Cell Physiol Biochem. 2011;28:513-20 pubmed publisher
    ..In summary, angiotensin II stimulates H(+)-ATPases in CNT/CCD intercalated cells, and may contribute to the regulation of chloride absorption and bicarbonate secretion in this nephron segment. ..
  8. Pech V, Pham T, Hong S, Weinstein A, Spencer K, Duke B, et al. Pendrin modulates ENaC function by changing luminal HCO3-. J Am Soc Nephrol. 2010;21:1928-41 pubmed publisher
    ..We conclude that pendrin modulates ENaC abundance and function, at least in part by increasing luminal [HCO(3)(-)] and/or pH. ..
  9. Takayanagi S, Takagi Y, Araki R, Hasegawa H. High-affinity nitrate uptake by rice (Oryza sativa) coleoptiles. J Plant Res. 2011;124:305-9 pubmed publisher
    ..These results suggest that rice coleoptiles may have high-affinity transport systems for nitrate similar to roots, and can be model organs for nutrient uptake by submerged plant shoots. ..
  10. Vatanavicharn N, Lachman R, Rimoin D. Multilayered patella: similar radiographic findings in pseudoachondroplasia and recessive multiple epiphyseal dysplasia. Am J Med Genet A. 2008;146A:1682-6 pubmed publisher

Detail Information

Publications74

  1. Jansen I, Mardones P, Lecanda F, de Vries T, Recalde S, Hoeben K, et al. Ae2(a,b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria. FASEB J. 2009;23:3470-81 pubmed publisher
    ..Possibly, this might compensate for the absence of Ae2 in calvaria osteoclasts of Ae2(a,b)(-/-) mice. ..
  2. Kiba T, Feria Bourrellier A, Lafouge F, Lezhneva L, Boutet Mercey S, Orsel M, et al. The Arabidopsis nitrate transporter NRT2.4 plays a double role in roots and shoots of nitrogen-starved plants. Plant Cell. 2012;24:245-58 pubmed publisher
    ..4 (triple mutants) has an impact on biomass production under low nitrate supply. Together, our results demonstrate that NRT2.4 is a nitrate transporter that has a role in both roots and shoots under N starvation. ..
  3. Kechid M, Desbrosses G, Rokhsi W, Varoquaux F, Djekoun A, Touraine B. The NRT2.5 and NRT2.6 genes are involved in growth promotion of Arabidopsis by the plant growth-promoting rhizobacterium (PGPR) strain Phyllobacterium brassicacearum STM196. New Phytol. 2013;198:514-24 pubmed publisher
    ..Our findings demonstrate that NRT2.5 and NRT2.6, which are preferentially expressed in leaves, play an essential role in plant growth promotion by the rhizospheric bacterium STM196. ..
  4. Tang J, Pecka J, Tan X, Beisel K, He D. Engineered pendrin protein, an anion transporter and molecular motor. J Biol Chem. 2011;286:31014-21 pubmed publisher
    ..Thus, the engineered pendrin was capable of both transporting anions and generating force. ..
  5. Li Y, Liu Z, Shi P, Zhang J. The hearing gene Prestin unites echolocating bats and whales. Curr Biol. 2010;20:R55-6 pubmed publisher
  6. Zuber H, Davidian J, Wirtz M, Hell R, Belghazi M, Thompson R, et al. Sultr4;1 mutant seeds of Arabidopsis have an enhanced sulphate content and modified proteome suggesting metabolic adaptations to altered sulphate compartmentalization. BMC Plant Biol. 2010;10:78 pubmed publisher
    ..The low-affinity sulphate transporters SULTR4;1 and SULTR4;2 have been localized to the vacuolar membrane, where they may facilitate sulphate efflux from the vacuole...
  7. Wagner C, Mohebbi N, Uhlig U, Giebisch G, Breton S, Brown D, et al. Angiotensin II stimulates H?-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts. Cell Physiol Biochem. 2011;28:513-20 pubmed publisher
    ..In summary, angiotensin II stimulates H(+)-ATPases in CNT/CCD intercalated cells, and may contribute to the regulation of chloride absorption and bicarbonate secretion in this nephron segment. ..
  8. Pech V, Pham T, Hong S, Weinstein A, Spencer K, Duke B, et al. Pendrin modulates ENaC function by changing luminal HCO3-. J Am Soc Nephrol. 2010;21:1928-41 pubmed publisher
    ..We conclude that pendrin modulates ENaC abundance and function, at least in part by increasing luminal [HCO(3)(-)] and/or pH. ..
  9. Takayanagi S, Takagi Y, Araki R, Hasegawa H. High-affinity nitrate uptake by rice (Oryza sativa) coleoptiles. J Plant Res. 2011;124:305-9 pubmed publisher
    ..These results suggest that rice coleoptiles may have high-affinity transport systems for nitrate similar to roots, and can be model organs for nutrient uptake by submerged plant shoots. ..
  10. Vatanavicharn N, Lachman R, Rimoin D. Multilayered patella: similar radiographic findings in pseudoachondroplasia and recessive multiple epiphyseal dysplasia. Am J Med Genet A. 2008;146A:1682-6 pubmed publisher
  11. Liang G, Yang F, Yu D. MicroRNA395 mediates regulation of sulfate accumulation and allocation in Arabidopsis thaliana. Plant J. 2010;62:1046-57 pubmed publisher
    ..Our research showed that miR395 is involved in the regulation of sulfate accumulation and allocation by targeting APS genes and SULTR2;1, respectively...
  12. Choi B, Kim H, Ito T, Lee K, Li X, Monahan K, et al. Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition. J Clin Invest. 2011;121:4516-25 pubmed publisher
    ..These data collectively provide mechanistic insight into hearing loss caused by SLC26A4 mutations and establish a model for further studies of EVA-associated hearing loss...
  13. Alesutan I, Daryadel A, Mohebbi N, Pelzl L, Leibrock C, Voelkl J, et al. Impact of bicarbonate, ammonium chloride, and acetazolamide on hepatic and renal SLC26A4 expression. Cell Physiol Biochem. 2011;28:553-8 pubmed publisher
    ..The observations point to expression of pendrin in the liver and to opposite effects of acidosis on pendrin transcription in liver and kidney...
  14. Dawson P, Russell C, Lee S, McLeay S, van Dongen J, Cowley D, et al. Urolithiasis and hepatotoxicity are linked to the anion transporter Sat1 in mice. J Clin Invest. 2010;120:706-12 pubmed publisher
    ..These data suggest that Sat1 regulates both oxalate and sulfate homeostasis and may be critical to the development of calcium oxalate urolithiasis and hepatotoxicity. ..
  15. Gröger N, Fröhlich H, Maier H, Olbrich A, Kostin S, Braun T, et al. SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria. J Biol Chem. 2010;285:14467-74 pubmed publisher
    ..SLC4A11 is essential for urinary concentration, suggesting that SLC4A11 participates in the countercurrent multiplication that concentrates urine in the kidney medulla...
  16. Criscuolo G, Valkov V, Parlati A, Alves L, Chiurazzi M. Molecular characterization of the Lotus japonicus NRT1(PTR) and NRT2 families. Plant Cell Environ. 2012;35:1567-81 pubmed publisher
    ..The interpretation of the global regulative networks obtained allowed to postulate roles for nitrate transporters as possible actors in the cross-talks between different signalling pathways triggered by biotic and abiotic factors. ..
  17. Bouguyon E, Gojon A, Nacry P. Nitrate sensing and signaling in plants. Semin Cell Dev Biol. 2012;23:648-54 pubmed publisher
    ..A breakthrough arising from this improved knowledge is a better understanding of the integration of NO(3)(-) and hormone signaling pathways, that explains the extraordinary developmental plasticity of plants in response to NO(3)(-)...
  18. Mahendrasingam S, Beurg M, Fettiplace R, Hackney C. The ultrastructural distribution of prestin in outer hair cells: a post-embedding immunogold investigation of low-frequency and high-frequency regions of the rat cochlea. Eur J Neurosci. 2010;31:1595-605 pubmed publisher
    ..The results suggest that prestin density, and by implication force production, is similar in low-frequency and high-frequency OHCs. ..
  19. Zifarelli G, Pusch M. Conversion of the 2 Cl(-)/1 H+ antiporter ClC-5 in a NO3(-)/H+ antiporter by a single point mutation. EMBO J. 2009;28:175-82 pubmed publisher
    ..2. A 2:1 stoichiometry appears to be a general property of CLC anion/proton exchangers. Serine 168 has an important function in determining anionic specificity of the exchange mechanism. ..
  20. Yong Z, Kotur Z, Glass A. Characterization of an intact two-component high-affinity nitrate transporter from Arabidopsis roots. Plant J. 2010;63:739-48 pubmed publisher
    ..The molecular mass of the intact oligomer suggests that the functional unit for high-affinity nitrate influx may be a tetramer consisting of two subunits each of AtNRT2.1 and AtNAR2.1. ..
  21. Banales J, Masyuk T, Bogert P, Huang B, Gradilone S, Lee S, et al. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Am J Pathol. 2008;173:1637-46 pubmed publisher
    ..Therapeutic interventions that block the activation of these proteins might inhibit cyst expansion in polycystic liver disease...
  22. Qu Q, Li X, An F, Jia G, Liu L, Watanabe Meserve H, et al. CrVI exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins. Biomarkers. 2008;13:467-77 pubmed
    ..88. The study suggests that Cr in RBC may serve as a sensitive and reliable biomarker for long-term exposure to CrVI. ..
  23. Hadchouel J, Büsst C, Procino G, Valenti G, Chambrey R, Eladari D. Regulation of extracellular fluid volume and blood pressure by pendrin. Cell Physiol Biochem. 2011;28:505-12 pubmed publisher
  24. Jia W, Tovell N, Clegg S, Trimmer M, Cole J. A single channel for nitrate uptake, nitrite export and nitrite uptake by Escherichia coli NarU and a role for NirC in nitrite export and uptake. Biochem J. 2009;417:297-304 pubmed publisher
    ..We propose that NarU functions as a single channel for nitrate uptake and nitrite expulsion, either as a nitrate-nitrite antiporter, or more likely as a nitrate/H+ or nitrite/H+ channel. ..
  25. Griffith A, Wangemann P. Hearing loss associated with enlargement of the vestibular aqueduct: mechanistic insights from clinical phenotypes, genotypes, and mouse models. Hear Res. 2011;281:11-7 pubmed publisher
    ..The enlargement is driven by fluid secretion in the vestibular labyrinth and a failure of fluid absorption in the embryonic endolymphatic sac. Elucidating the mechanism of hearing loss may offer clues to potential therapeutic strategies...
  26. Kim H, Wangemann P. Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin. PLoS ONE. 2011;6:e17949 pubmed publisher
  27. Dror A, Politi Y, Shahin H, Lenz D, Dossena S, Nofziger C, et al. Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation. J Biol Chem. 2010;285:21724-35 pubmed publisher
    ..We propose a novel mechanism for the accumulation and aggregation of oxalate crystals in the inner ear. ..
  28. Rennenberg H, Wildhagen H, Ehlting B. Nitrogen nutrition of poplar trees. Plant Biol (Stuttg). 2010;12:275-91 pubmed publisher
  29. Tan X, Pecka J, Tang J, Okoruwa O, Zhang Q, Beisel K, et al. From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells. J Neurophysiol. 2011;105:36-44 pubmed publisher
    ..Our results suggest that motor function is an innovation of therian prestin and is concurrent with diminished transporter capabilities. ..
  30. Ho C, Lin S, Hu H, Tsay Y. CHL1 functions as a nitrate sensor in plants. Cell. 2009;138:1184-94 pubmed publisher
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online. ..
  31. Camañes G, Pastor V, Cerezo M, García Andrade J, Vicedo B, García Agustín P, et al. A deletion in NRT2.1 attenuates Pseudomonas syringae-induced hormonal perturbation, resulting in primed plant defenses. Plant Physiol. 2012;158:1054-66 pubmed publisher
    ..These results suggest additional functions for NRT2.1 that may influence plant disease resistance by down-regulating biotic stress defense mechanisms and favoring abiotic stress responses...
  32. Hemadevi B, Srinivasan M, Arunkumar J, Prajna N, Sundaresan P. Genetic analysis of patients with Fuchs endothelial corneal dystrophy in India. BMC Ophthalmol. 2010;10:3 pubmed publisher
    ..These results suggest that COL8A2, SLC4A11 genes may not be responsible for FECD in patients examined in this study. ..
  33. Sun S, Farrell B, Chana M, Oster G, Brownell W, Spector A. Voltage and frequency dependence of prestin-associated charge transfer. J Theor Biol. 2009;260:137-44 pubmed publisher
    ..The revealed nature of the transferred charge can help reconcile the high-frequency electrical and mechanical observations associated with prestin, and it is important for further analysis of the structure and function of this protein. ..
  34. Teek R, Oitmaa E, Kruustük K, Zordania R, Joost K, Raukas E, et al. Splice variant IVS2-2A>G in the SLC26A5 (Prestin) gene in five Estonian families with hearing loss. Int J Pediatr Otorhinolaryngol. 2009;73:103-7 pubmed publisher
    ..Our data support the hypothesis that heterozygosity for the mutation IVS2-2A>G in SLC26A5 gene may not, by itself, be sufficient to cause hearing loss. ..
  35. Wang Y, Hsu P, Tsay Y. Uptake, allocation and signaling of nitrate. Trends Plant Sci. 2012;17:458-67 pubmed publisher
    ..Interestingly, several of these transporters also play versatile roles in nitrate sensing, plant development, pathogen defense, and/or stress response...
  36. Hemadevi B, Veitia R, Srinivasan M, Arunkumar J, Prajna N, Lesaffre C, et al. Identification of mutations in the SLC4A11 gene in patients with recessive congenital hereditary endothelial dystrophy. Arch Ophthalmol. 2008;126:700-8 pubmed publisher
    ..To identify Solute Carrier family 4 (sodium borate cotransporter) member 11 (SLC4A11) gene mutations associated with autosomal recessive congenital hereditary endothelial dystrophy (CHED2)...
  37. Qin L, Liu X, Sun Q, Fan Z, Xia D, Ding G, et al. Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proc Natl Acad Sci U S A. 2012;109:13434-9 pubmed publisher
    ..We suggest that the 2NO(3)(-)/H(+) transport function of sialin in salivary glands can contribute significantly to clearance of serum nitrate, as well as nitrate recycling and physiological nitrite-NO homeostasis...
  38. Kawashima C, Yoshimoto N, Maruyama Nakashita A, Tsuchiya Y, Saito K, Takahashi H, et al. Sulphur starvation induces the expression of microRNA-395 and one of its target genes but in different cell types. Plant J. 2009;57:313-21 pubmed publisher
    ..These results illustrate that negative temporal correlation between the expression level of a miRNA and its target gene in a complex tissue cannot be a requirement for target gene validation. ..
  39. Boursiac Y, Léran S, Corratgé Faillie C, Gojon A, Krouk G, Lacombe B. ABA transport and transporters. Trends Plant Sci. 2013;18:325-33 pubmed publisher
    ..Given that the NRT1/PTR family is involved in the transport of nitrogen (N) compounds, further work should determine whether an interaction between ABA and N signaling or nutrition occurs. ..
  40. Cai C, Wang J, Zhu Y, Shen Q, Li B, Tong Y, et al. Gene structure and expression of the high-affinity nitrate transport system in rice roots. J Integr Plant Biol. 2008;50:443-51 pubmed publisher
    ..5, alkaline pH (pH 8.0) inhibited nitrate influx, and acidic pH (pH 5.0) enhanced the nitrate influx in 1 h nitrate induced roots, but did not significantly affect that in 4 to 8 h nitrate induced roots. ..
  41. Miyake A, Nishimura G, Futami T, Ohashi H, Chiba K, Toyama Y, et al. A compound heterozygote of novel and recurrent DTDST mutations results in a novel intermediate phenotype of Desbuquois dysplasia, diastrophic dysplasia, and recessive form of multiple epiphyseal dysplasia. J Hum Genet. 2008;53:764-8 pubmed publisher
    ..T266I was predicted to be responsible for mild phenotypes of the DTD group. Our results further extend the phenotypic spectrum of DTDST mutations, adding Desbuquois dysplasia to the list of differential diagnosis of the DTD group. ..
  42. Zuber H, Davidian J, Aubert G, Aimé D, Belghazi M, Lugan R, et al. The seed composition of Arabidopsis mutants for the group 3 sulfate transporters indicates a role in sulfate translocation within developing seeds. Plant Physiol. 2010;154:913-26 pubmed publisher
    ..Metabolic adjustments were also revealed, some of which could release sulfur from glucosinolates...
  43. Wang Y, Tsay Y. Arabidopsis nitrate transporter NRT1.9 is important in phloem nitrate transport. Plant Cell. 2011;23:1945-57 pubmed publisher
    ..9 in root companion cells. In addition, enhanced root-to-shoot xylem transport of nitrate in nrt1.9 mutants points to a negative correlation between xylem and phloem nitrate transport. ..
  44. Hallworth R, Nichols M. Prestin in HEK cells is an obligate tetramer. J Neurophysiol. 2012;107:5-11 pubmed publisher
    ..The average step count for this molecule was also 2.7. This result implies that in cell membranes prestin oligomerizes to a tetramer. ..
  45. Kotur Z, Mackenzie N, Ramesh S, Tyerman S, Kaiser B, Glass A. Nitrate transport capacity of the Arabidopsis thaliana NRT2 family members and their interactions with AtNAR2.1. New Phytol. 2012;194:724-31 pubmed publisher
    ..1. • Co-injection into Xenopus oocytes of cRNA of all NRT2 genes together with cRNA of AtNAR2.1 resulted in statistically significant increases of uptake over and above that resulting from single cRNA injections...
  46. Amlal H, Soleimani M. Pendrin as a novel target for diuretic therapy. Cell Physiol Biochem. 2011;28:521-6 pubmed publisher
    ..We propose that pharmacologic inhibition of pendrin and NCC can provide a novel and strong diuretic regimen for patients with fluid overload, including those with congestive heart failure, nephrotic syndrome or renal failure. ..
  47. Feng H, Yan M, Fan X, Li B, Shen Q, Miller A, et al. Spatial expression and regulation of rice high-affinity nitrate transporters by nitrogen and carbon status. J Exp Bot. 2011;62:2319-32 pubmed publisher
    ..The results imply distinct physiological functions for each OsNRT2 transporter, and differential regulation pathways by N and C status. ..
  48. Lin S, Kuo H, Canivenc G, Lin C, Lepetit M, Hsu P, et al. Mutation of the Arabidopsis NRT1.5 nitrate transporter causes defective root-to-shoot nitrate transport. Plant Cell. 2008;20:2514-28 pubmed publisher
    ..5, another mechanism is responsible for xylem loading of nitrate. Further analyses of the nrt1.5 mutants revealed a regulatory loop between nitrate and potassium at the xylem transport step. ..
  49. Ide Y, Kusano M, Oikawa A, Fukushima A, Tomatsu H, Saito K, et al. Effects of molybdenum deficiency and defects in molybdate transporter MOT1 on transcript accumulation and nitrogen/sulphur metabolism in Arabidopsis thaliana. J Exp Bot. 2011;62:1483-97 pubmed publisher
    ..These results are the first investigation of the global effect of Mo nutrition and MOT1 on plant gene expressions and metabolism...
  50. Kim H, Wangemann P. Failure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expression. PLoS ONE. 2010;5:e14041 pubmed publisher
    ..Failure of fluid absorption in the endolymphatic sac due to lack of Slc26a4 expression appears to initiate cochlear enlargement in mice, and possibly humans, lacking functional Slc26a4 expression...
  51. Wu J, Glimcher L, Aliprantis A. HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A. 2008;105:16934-9 pubmed publisher
    ..These data highlight SLC4A2 as a critical mediator of osteoclast differentiation and function in vitro and in vivo...
  52. Hafner P, Grimaldi R, Capuano P, Capasso G, Wagner C. Pendrin in the mouse kidney is primarily regulated by Cl- excretion but also by systemic metabolic acidosis. Am J Physiol Cell Physiol. 2008;295:C1658-67 pubmed publisher
    ..However, metabolic acidosis caused by acetazolamide or (NH(4))(2)SO(4) loading prevented the increase or even reduced pendrin expression despite low urinary Cl(-) excretion, suggesting an independent regulation by acid-base status...
  53. Okoruwa O, Weston M, Sanjeevi D, Millemon A, Fritzsch B, Hallworth R, et al. Evolutionary insights into the unique electromotility motor of mammalian outer hair cells. Evol Dev. 2008;10:300-15 pubmed publisher
    ..We were able to identify that within the highly conserved meEM motif two regions, which are unique to all therian species, appear to be the most derived features in the SLC26A5 peptide. ..
  54. Almagro A, Lin S, Tsay Y. Characterization of the Arabidopsis nitrate transporter NRT1.6 reveals a role of nitrate in early embryo development. Plant Cell. 2008;20:3289-99 pubmed publisher
    ..Interestingly, the seed abortion rate of the mutant was reduced when grown under N-deficient conditions, suggesting that nitrate requirements in early embryo development can be modulated in response to external nitrogen changes. ..
  55. Mehta J, Hemadevi B, Vithana E, Arunkumar J, Srinivasan M, Prajna V, et al. Absence of phenotype-genotype correlation of patients expressing mutations in the SLC4A11 gene. Cornea. 2010;29:302-6 pubmed publisher
  56. Gojon A, Krouk G, Perrine Walker F, Laugier E. Nitrate transceptor(s) in plants. J Exp Bot. 2011;62:2299-308 pubmed publisher
    ..1 is a representative of this class of protein. The various facets, as well as the mechanisms of nitrate sensing by NRT1.1 are considered, and the possible occurrence of other nitrate transceptors is discussed. ..
  57. Li G, Wang J, Rossiter S, Jones G, Cotton J, Zhang S. The hearing gene Prestin reunites echolocating bats. Proc Natl Acad Sci U S A. 2008;105:13959-64 pubmed publisher
    ..These results highlight the potential problems of extracting phylogenetic signals from functional genes that may be prone to convergence...
  58. Liu J, Seet L, Koh L, Venkatraman A, Venkataraman D, Mohan R, et al. Depletion of SLC4A11 causes cell death by apoptosis in an immortalized human corneal endothelial cell line. Invest Ophthalmol Vis Sci. 2012;53:3270-9 pubmed publisher
    ..This suggests that SLC4A11 is necessary for cell survival and may explain the pathologic corneal endothelial cell loss in endotheliopathies due to SLC4A11 mutations. ..
  59. Josephsen K, Praetorius J, Frische S, Gawenis L, Kwon T, Agre P, et al. Targeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in mice. Proc Natl Acad Sci U S A. 2009;106:1638-41 pubmed publisher
    ..Furthermore, osteoclasts in Ae2-/- mice were dramatically enlarged and fail to form the normal ruffled border facing the lacunae. Thus, Ae2 is likely to be an essential component of the bone resorption mechanism in osteoclasts. ..
  60. Tan X, Pecka J, Tang J, Lovas S, Beisel K, He D. A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin. J Cell Sci. 2012;125:1039-47 pubmed publisher
    ..Thus, this motif represents the structural adaptation that assists gain of motor function in eutherian prestin...
  61. Bai J, Surguchev A, Montoya S, Aronson P, Santos Sacchi J, Navaratnam D. Prestin's anion transport and voltage-sensing capabilities are independent. Biophys J. 2009;96:3179-86 pubmed publisher
    ..Finally, we distinguish 12 charged residues out of 22, residing within prestin's transmembrane regions, that contribute to unitary charge movement, i.e., voltage sensing. These data redefine our mechanistic concept of prestin. ..
  62. Fan S, Lin C, Hsu P, Lin S, Tsay Y. The Arabidopsis nitrate transporter NRT1.7, expressed in phloem, is responsible for source-to-sink remobilization of nitrate. Plant Cell. 2009;21:2750-61 pubmed publisher
  63. Pasqualetto E, Aiello R, Gesiot L, Bonetto G, Bellanda M, Battistutta R. Structure of the cytosolic portion of the motor protein prestin and functional role of the STAS domain in SLC26/SulP anion transporters. J Mol Biol. 2010;400:448-62 pubmed publisher
    ..Mapping of disease-associated or functionally harmful mutations on STAS structure indicates that they can be divided into two categories: those causing significant misfolding of the domain and those altering its interaction properties. ..
  64. Li J, Fu Y, Pike S, Bao J, Tian W, Zhang Y, et al. The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance. Plant Cell. 2010;22:1633-46 pubmed publisher
    ..8-1 mutant. These data suggest that NRT1.8-regulated nitrate distribution plays an important role in Cd(2+) tolerance. ..
  65. Purkerson J, Tsuruoka S, Suter D, Nakamori A, Schwartz G. Adaptation to metabolic acidosis and its recovery are associated with changes in anion exchanger distribution and expression in the cortical collecting duct. Kidney Int. 2010;78:993-1005 pubmed publisher
    ..Thus, regulation of intercalated cell anion exchanger expression and distribution plays a key role in adaptation of the cortical collecting duct to perturbations of acid/base...
  66. Mor re Le Paven M, Viau L, Hamon A, Vandecasteele C, Pellizzaro A, Bourdin C, et al. Characterization of a dual-affinity nitrate transporter MtNRT1.3 in the model legume Medicago truncatula. J Exp Bot. 2011;62:5595-605 pubmed publisher
    ..The results suggest that MtNRT1.3 is involved in the response to N limitation, which increases the ability of the plant to acquire NO(3)(-) under N-limiting conditions...
  67. Dechorgnat J, Nguyen C, Armengaud P, Jossier M, Diatloff E, Filleur S, et al. From the soil to the seeds: the long journey of nitrate in plants. J Exp Bot. 2011;62:1349-59 pubmed publisher
    ..All these fluxes are controlled by key factors, the 'major tour operators' like the internal nutritional status of the plant but also by external abiotic factors. ..
  68. Paliwal P, Sharma A, Tandon R, Sharma N, Titiyal J, Sen S, et al. Congenital hereditary endothelial dystrophy - mutation analysis of SLC4A11 and genotype-phenotype correlation in a North Indian patient cohort. Mol Vis. 2010;16:2955-63 pubmed
    ..The present study detected one novel and three reported changes, adding to the repertoire of mutations in SLC4A11, and recorded a high degree of genetic heterogeneity in CHED2. ..
  69. Yang T, Gurrola J, Wu H, Chiu S, Wangemann P, Snyder P, et al. Mutations of KCNJ10 together with mutations of SLC26A4 cause digenic nonsyndromic hearing loss associated with enlarged vestibular aqueduct syndrome. Am J Hum Genet. 2009;84:651-7 pubmed publisher
    ..Our results link KCNJ10 mutations with EVA/PS and provide further support for the model of EVA/PS as a multigenic complex disease. ..
  70. Wagner C, Mohebbi N, Capasso G, Geibel J. The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis. Cell Physiol Biochem. 2011;28:497-504 pubmed publisher
    ..This review summarizes recent findings on the role and regulation of pendrin in the context of the kidneys role in acid-base homeostasis in health and disease. ..
  71. Riazuddin S, Vithana E, Seet L, Liu Y, Al Saif A, Koh L, et al. Missense mutations in the sodium borate cotransporter SLC4A11 cause late-onset Fuchs corneal dystrophy. Hum Mutat. 2010;31:1261-8 pubmed publisher
    ..Taken together with a recent model between FCD and yet another early onset corneal dystrophy, PPCD, our data suggest a shared pathomechanism and genetic overlap across several corneal dystrophies. ..
  72. Lu W, Schwarzer N, Du J, Gerbig Smentek E, Andrade S, Einsle O. Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium. Proc Natl Acad Sci U S A. 2012;109:18395-400 pubmed publisher
    ..Resolved water molecules in the protomers suggest a transport mechanism that also permits a facultative NO(2)(-)/H(+) symport...
  73. Yan H, Huang W, Yan C, Gong X, Jiang S, Zhao Y, et al. Structure and mechanism of a nitrate transporter. Cell Rep. 2013;3:716-23 pubmed publisher
    ..The observed conformational differences of NarU, together with unique sequence features of the NNP family transporters, suggest a transport mechanism that might deviate from the canonical rocker-switch model...
  74. Zheng H, Wisedchaisri G, Gonen T. Crystal structure of a nitrate/nitrite exchanger. Nature. 2013;497:647-51 pubmed publisher
    ..We propose that NarK exchanges nitrate for nitrite by a rocker switch mechanism facilitated by inter-domain hydrogen bond networks...