acetazolamide

Summary

Summary: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Top Publications

  1. Subudhi A, Dimmen A, Julian C, Wilson M, Panerai R, Roach R. Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia. J Appl Physiol (1985). 2011;110:1219-25 pubmed publisher
    ..use of randomized, placebo-controlled, double-blind, crossover design, 20 healthy volunteers were given oral acetazolamide (250 mg), dexamethasone (4 mg), or placebo every 8 h for 24 h prior to and during a 10-h exposure to a ..
  2. Vagal A, Leach J, Fernandez Ulloa M, Zuccarello M. The acetazolamide challenge: techniques and applications in the evaluation of chronic cerebral ischemia. AJNR Am J Neuroradiol. 2009;30:876-84 pubmed publisher
    The acetazolamide (ACZ) challenge test is a useful clinical tool and a reliable predictor of critically reduced perfusion...
  3. Basnyat B, Hargrove J, Holck P, Srivastav S, Alekh K, Ghimire L, et al. Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans. High Alt Med Biol. 2008;9:209-16 pubmed publisher
    In this randomized, double-blind placebo controlled trial our objectives were to determine if acetazolamide is capable of preventing high altitude pulmonary edema (HAPE) in trekkers traveling between 4250 m (Pheriche)\4350 m (Dingboche) ..
  4. Ferrante E, Arpino I, Citterio A, Wetzl R, Savino A. Epidural blood patch in Trendelenburg position pre-medicated with acetazolamide to treat spontaneous intracranial hypotension. Eur J Neurol. 2010;17:715-9 pubmed publisher
    ..with SIH were treated with lumbar autologous EBP in Trendelenburg position preceded by pre-medication with acetazolamide. A complete recovery was obtained in all patients after one (90%), two (5%) or three (5%) EBPs...
  5. Falardeau J, Lobb B, Golden S, Maxfield S, Tanne E. The use of acetazolamide during pregnancy in intracranial hypertension patients. J Neuroophthalmol. 2013;33:9-12 pubmed publisher
    b>Acetazolamide is the mainstay of medical therapy for idiopathic intracranial hypertension (IIH). Its use in pregnant women has not been recommended because of reported teratogenic effects in rodents and rabbits...
  6. Andaluz N, Choutka O, Vagal A, Strunk R, Zuccarello M. Patient selection for revascularization procedures in adult Moyamoya disease based on dynamic perfusion computerized tomography with acetazolamide challenge (PCTA). Neurosurg Rev. 2010;33:225-32; discussion 232-3 pubmed publisher
    ..The purpose of the study was to assess the utility of perfusion computerized tomography with acetazolamide challenge (PCTA) in the evaluation of cerebral perfusion and cerebrovascular reserve (CVR) in adult Moyamoya ..
  7. Kayser B, Dumont L, Lysakowski C, Combescure C, Haller G, Tramer M. Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysis. High Alt Med Biol. 2012;13:82-92 pubmed publisher
    b>Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness...
  8. Park S, Park H, Kim D, Yang C, Zhang L. The prediction of gross motor outcome using cerebrovascular reserve measured by acetazolamide-challenged SPECT. NeuroRehabilitation. 2012;30:359-67 pubmed publisher
    ..The CVR was measured as the difference in the regional cerebral blood flow (rCBF) after acetazolamide (ACZ)-challenged(99m)Tc-ECD perfusion SPECT from baseline rCBF. All 22 hemiplegic patients (mean age, 60...
  9. Omata T, Takanashi J, Wada T, Arai H, Tanabe Y. Genetic diagnosis and acetazolamide treatment of familial hemiplegic migraine. Brain Dev. 2011;33:332-4 pubmed publisher
    ..To avoid missing FHM1, a detailed clinical history including headache or hemiplegia is essential. Oral acetazolamide during the aura phase, comprising mild headache and abnormal leg sensation, relieved these symptoms in this ..
  10. Granero G, Longhi M. Promising complexes of acetazolamide for topical ocular administration. Expert Opin Drug Deliv. 2010;7:943-53 pubmed publisher
    b>Acetazolamide (ACZ), a carbonic anhydrase inhibitor (CAI), and other oral CAIs have been an integral part of antiglaucoma therapy for > 40 years...

Detail Information

Publications71

  1. Subudhi A, Dimmen A, Julian C, Wilson M, Panerai R, Roach R. Effects of acetazolamide and dexamethasone on cerebral hemodynamics in hypoxia. J Appl Physiol (1985). 2011;110:1219-25 pubmed publisher
    ..use of randomized, placebo-controlled, double-blind, crossover design, 20 healthy volunteers were given oral acetazolamide (250 mg), dexamethasone (4 mg), or placebo every 8 h for 24 h prior to and during a 10-h exposure to a ..
  2. Vagal A, Leach J, Fernandez Ulloa M, Zuccarello M. The acetazolamide challenge: techniques and applications in the evaluation of chronic cerebral ischemia. AJNR Am J Neuroradiol. 2009;30:876-84 pubmed publisher
    The acetazolamide (ACZ) challenge test is a useful clinical tool and a reliable predictor of critically reduced perfusion...
  3. Basnyat B, Hargrove J, Holck P, Srivastav S, Alekh K, Ghimire L, et al. Acetazolamide fails to decrease pulmonary artery pressure at high altitude in partially acclimatized humans. High Alt Med Biol. 2008;9:209-16 pubmed publisher
    In this randomized, double-blind placebo controlled trial our objectives were to determine if acetazolamide is capable of preventing high altitude pulmonary edema (HAPE) in trekkers traveling between 4250 m (Pheriche)\4350 m (Dingboche) ..
  4. Ferrante E, Arpino I, Citterio A, Wetzl R, Savino A. Epidural blood patch in Trendelenburg position pre-medicated with acetazolamide to treat spontaneous intracranial hypotension. Eur J Neurol. 2010;17:715-9 pubmed publisher
    ..with SIH were treated with lumbar autologous EBP in Trendelenburg position preceded by pre-medication with acetazolamide. A complete recovery was obtained in all patients after one (90%), two (5%) or three (5%) EBPs...
  5. Falardeau J, Lobb B, Golden S, Maxfield S, Tanne E. The use of acetazolamide during pregnancy in intracranial hypertension patients. J Neuroophthalmol. 2013;33:9-12 pubmed publisher
    b>Acetazolamide is the mainstay of medical therapy for idiopathic intracranial hypertension (IIH). Its use in pregnant women has not been recommended because of reported teratogenic effects in rodents and rabbits...
  6. Andaluz N, Choutka O, Vagal A, Strunk R, Zuccarello M. Patient selection for revascularization procedures in adult Moyamoya disease based on dynamic perfusion computerized tomography with acetazolamide challenge (PCTA). Neurosurg Rev. 2010;33:225-32; discussion 232-3 pubmed publisher
    ..The purpose of the study was to assess the utility of perfusion computerized tomography with acetazolamide challenge (PCTA) in the evaluation of cerebral perfusion and cerebrovascular reserve (CVR) in adult Moyamoya ..
  7. Kayser B, Dumont L, Lysakowski C, Combescure C, Haller G, Tramer M. Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysis. High Alt Med Biol. 2012;13:82-92 pubmed publisher
    b>Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness...
  8. Park S, Park H, Kim D, Yang C, Zhang L. The prediction of gross motor outcome using cerebrovascular reserve measured by acetazolamide-challenged SPECT. NeuroRehabilitation. 2012;30:359-67 pubmed publisher
    ..The CVR was measured as the difference in the regional cerebral blood flow (rCBF) after acetazolamide (ACZ)-challenged(99m)Tc-ECD perfusion SPECT from baseline rCBF. All 22 hemiplegic patients (mean age, 60...
  9. Omata T, Takanashi J, Wada T, Arai H, Tanabe Y. Genetic diagnosis and acetazolamide treatment of familial hemiplegic migraine. Brain Dev. 2011;33:332-4 pubmed publisher
    ..To avoid missing FHM1, a detailed clinical history including headache or hemiplegia is essential. Oral acetazolamide during the aura phase, comprising mild headache and abnormal leg sensation, relieved these symptoms in this ..
  10. Granero G, Longhi M. Promising complexes of acetazolamide for topical ocular administration. Expert Opin Drug Deliv. 2010;7:943-53 pubmed publisher
    b>Acetazolamide (ACZ), a carbonic anhydrase inhibitor (CAI), and other oral CAIs have been an integral part of antiglaucoma therapy for > 40 years...
  11. Frydrychowski A, Wszedybyl Winklewska M, Gumiński W, Lass P, Bandurski T, Winklewski P. Effects of acute hypercapnia on the amplitude of cerebrovascular pulsation in humans registered with a non-invasive method. Microvasc Res. 2012;83:229-36 pubmed publisher
    ..The aim of the study was to assess non-invasively the effects of acute hypercapnia on the amplitude of cerebrovascular pulsation (CVP) in humans...
  12. Palma S, Tartara L, Quinteros D, Allemandi D, Longhi M, Granero G. An efficient ternary complex of acetazolamide with HP-ss-CD and TEA for topical ocular administration. J Control Release. 2009;138:24-31 pubmed publisher
    In order to enhance the ocular bioavailability of acetazolamide (ACZ), a multicomponent complex with hydroxypropyl-ss-cyclodextrin (HP-ss-CD) and triethanolamine (TEA) was prepared to be applied topically...
  13. Schreiner C, Bell S, Scott W. Microarray analysis of murine limb bud ectoderm and mesoderm after exposure to cadmium or acetazolamide. Birth Defects Res A Clin Mol Teratol. 2009;85:588-98 pubmed publisher
    ..We have studied two of these teratogens, acetazolamide and cadmium, using the technique of microarray analysis of limb bud ectoderm and mesoderm to search for ..
  14. Teppema L, van Dorp E, Dahan A. Arterial [H+] and the ventilatory response to hypoxia in humans: influence of acetazolamide-induced metabolic acidosis. Am J Physiol Lung Cell Mol Physiol. 2010;298:L89-95 pubmed publisher
    ..We used acetazolamide to induce a metabolic acidosis...
  15. Park S, Yang C, Choi S, Kim W. Assessment of cerebral hemodynamics to acetazolamide using brain perfusion SPECT in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Clin Nucl Med. 2011;36:158-9 pubmed publisher
    ..b>Acetazolamide (ACZ) has been promoted as a drug to determine cerebral hemodynamics, including cerebral blood flow (CBF) and ..
  16. Xu J, Peng Z, Li R, Dou T, Xu W, Gu G, et al. Normoxic induction of cerebral HIF-1alpha by acetazolamide in rats: role of acidosis. Neurosci Lett. 2009;451:274-8 pubmed publisher
    b>Acetazolamide has been recognized as an effective treatment for acute mountain sickness. The efficacy of acetazolamide is related to metabolic acidosis, which promotes chemoreceptors to respond to hypoxic stimuli at altitude...
  17. Cianchi F, Vinci M, Supuran C, Peruzzi B, De Giuli P, Fasolis G, et al. Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells. J Pharmacol Exp Ther. 2010;334:710-9 pubmed publisher
    ..The aim of this study was to evaluate the antitumor activity of three CA inhibitors, namely acetazolamide (AZ) and two newly synthesized aromatic sulfonamides with high affinity for CA IX, 2-(4-sulfamoylphenyl-amino)-..
  18. Fan J, Burgess K, Thomas K, Lucas S, Cotter J, Kayser B, et al. Effects of acetazolamide on cerebrovascular function and breathing stability at 5050 m. J Physiol. 2012;590:1213-25 pubmed publisher
    One of the many actions of the carbonic anhydrase inhibitor, acetazolamide (ACZ), is to accelerate acclimatisation and reduce periodic breathing during sleep...
  19. Ritchie N, Baggott A, Andrew Todd W. Acetazolamide for the prevention of acute mountain sickness--a systematic review and meta-analysis. J Travel Med. 2012;19:298-307 pubmed publisher
    b>Acetazolamide has been reported to be effective in the prevention of acute mountain sickness (AMS). Our aim was to conduct a systematic review of randomized, placebo-controlled trials of acetazolamide in the prevention of AMS...
  20. Aamand R, Skewes J, Møller A, Fago A, Roepstorff A. Enhancing effects of acetazolamide on neuronal activity correlate with enhanced visual processing ability in humans. Neuropharmacology. 2011;61:900-8 pubmed publisher
    b>Acetazolamide is a potent inhibitor of the reversible hydration of CO(2) catalyzed by the enzyme carbonic anhydrase and is commonly used to increase cerebral blood flow e.g. in order to estimate cerebrovascular reserve...
  21. Kumar R, Tan D, Por Y, Oen F, Hoh S, Parthasarathy A, et al. Glaucoma management in patients with osteo-odonto-keratoprosthesis (OOKP): the Singapore OOKP Study. J Glaucoma. 2009;18:354-60 pubmed publisher
    ..All patients with glaucoma were treated with oral acetazolamide 500 mg twice a day. Transscleral cyclophotocoagulation was performed in 3 eyes at stage 2 of OOKP surgery...
  22. Kayser B, Hulsebosch R, Bosch F. Low-dose acetylsalicylic acid analog and acetazolamide for prevention of acute mountain sickness. High Alt Med Biol. 2008;9:15-23 pubmed publisher
    ..A third noncontrolled open arm was proposed-the usual recommended preventive treatment of acetazolamide 500 mg/day...
  23. Heming N, Faisy C, Urien S. Population pharmacodynamic model of bicarbonate response to acetazolamide in mechanically ventilated chronic obstructive pulmonary disease patients. Crit Care. 2011;15:R213 pubmed publisher
    b>Acetazolamide is commonly given to chronic obstructive pulmonary disease (COPD) patients with metabolic alkalosis. Little is known of the pharmacodynamics of acetazolamide in the critically ill...
  24. Gertsch J, Lipman G, Holck P, Merritt A, Mulcahy A, Fisher R, et al. Prospective, double-blind, randomized, placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache: the Headache Evaluation at Altitude Trial (HEAT). Wilderness Environ Med. 2010;21:236-43 pubmed publisher
    ..Toward this end, we initiated a prospective, double-blind, randomized, placebo-controlled trial in the Nepal Himalaya designed to compare the effectiveness of ibuprofen and acetazolamide for the prevention of HAH.
  25. Seupaul R, Welch J, Malka S, Emmett T. Pharmacologic prophylaxis for acute mountain sickness: a systematic shortcut review. Ann Emerg Med. 2012;59:307-317.e1 pubmed publisher
    ..A systematic review of this subject published in 2000 found that both acetazolamide and dexamethasone were effective. Since 2000, a number of other agents have been reported to be beneficial...
  26. Fisher S, Aggarwal M, Kovalevsky A, Silverman D, McKenna R. Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding. J Am Chem Soc. 2012;134:14726-9 pubmed publisher
    ..As such, CA isoforms are prominent clinical targets for treating various diseases. The clinically used acetazolamide (AZM) is a sulfonamide that binds with high affinity to human CA isoform II (HCA II)...
  27. Iida H, Nakagawara J, Hayashida K, Fukushima K, Watabe H, Koshino K, et al. Multicenter evaluation of a standardized protocol for rest and acetazolamide cerebral blood flow assessment using a quantitative SPECT reconstruction program and split-dose 123I-iodoamphetamine. J Nucl Med. 2010;51:1624-31 pubmed publisher
    ..been developed to reconstruct quantitative SPECT images and assess cerebral blood flow (CBF) at rest and after acetazolamide challenge from a single SPECT session...
  28. Faisy C, Mokline A, Sanchez O, Tadie J, Fagon J. Effectiveness of acetazolamide for reversal of metabolic alkalosis in weaning COPD patients from mechanical ventilation. Intensive Care Med. 2010;36:859-63 pubmed publisher
    To evaluate the effects of a single daily dose of acetazolamide (ACET) on metabolic alkalosis and respiratory parameters in weaning chronic obstructive pulmonary disease (COPD) patients from invasive mechanical ventilation.
  29. Rivera Ch M, Huicho L, Bouchet P, Richalet J, Leon Velarde F. Effect of acetazolamide on ventilatory response in subjects with chronic mountain sickness. Respir Physiol Neurobiol. 2008;162:184-9 pubmed publisher
    Although the effects of acetazolamide (ACZ) on ventilation during acute mountain sickness are well known, there are no studies assessing its effect on ventilatory response in chronic hypoxia...
  30. Tricarico D, Lovaglio S, Mele A, Rotondo G, Mancinelli E, Meola G, et al. Acetazolamide prevents vacuolar myopathy in skeletal muscle of K(+) -depleted rats. Br J Pharmacol. 2008;154:183-90 pubmed publisher
    b>Acetazolamide and dichlorphenamide are carbonic anhydrase (CA) inhibitors effective in the clinical condition of hypokalemic periodic paralysis (hypoPP)...
  31. Saito H, Ogasawara K, Suzuki T, Kuroda H, Kobayashi M, Yoshida K, et al. Adverse effects of intravenous acetazolamide administration for evaluation of cerebrovascular reactivity using brain perfusion single-photon emission computed tomography in patients with major cerebral artery steno-occlusive diseases. Neurol Med Chir (Tokyo). 2011;51:479-83 pubmed
    Adverse effects of intravenous acetazolamide administration for evaluation of cerebrovascular reactivity using brain perfusion single-photon emission computed tomography (SPECT) were prospectively investigated in 100 patients with major ..
  32. Synofzik M, Schicks J, Lindig T, Biskup S, Schmidt T, Hansel J, et al. Acetazolamide-responsive exercise-induced episodic ataxia associated with a novel homozygous DARS2 mutation. J Med Genet. 2011;48:713-5 pubmed publisher
    ..So far, affected individuals were invariably compound heterozygous for two mutations in DARS2, and drug treatments have remained elusive...
  33. Bin K, Shi Peng Z. Acetazolamide inhibits aquaporin-1 expression and colon cancer xenograft tumor growth. Hepatogastroenterology. 2011;58:1502-6 pubmed publisher
    To study the effects of water channel protein inhibitor acetazolamide on xenograft tumor growth of colon cancer in nude mice...
  34. Kassamali R, Sica D. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011;19:276-8 pubmed publisher
    b>Acetazolamide is the only carbonic anhydrase inhibitor with significant diuretic effects. It is readily absorbed and undergoes renal elimination by tubular secretion. Its administration is ordinarily marked by a brisk alkaline diuresis...
  35. Pakfetrat M, Nikoo M, Malekmakan L, Tabandeh M, Roozbeh J, Nasab M, et al. A comparison of sodium bicarbonate infusion versus normal saline infusion and its combination with oral acetazolamide for prevention of contrast-induced nephropathy: a randomized, double-blind trial. Int Urol Nephrol. 2009;41:629-34 pubmed publisher
    ..Bi) infusion in dextrose water versus normal saline (NLS) infusion alone or in combination with oral acetazolamide (AZ)...
  36. Hokari M, Kuroda S, Shiga T, Nakayama N, Tamaki N, Iwasaki Y. Combination of a mean transit time measurement with an acetazolamide test increases predictive power to identify elevated oxygen extraction fraction in occlusive carotid artery diseases. J Nucl Med. 2008;49:1922-7 pubmed publisher
    Reduced cerebral blood flow and cerebrovascular reactivity to acetazolamide have been used as predictors for subsequent ischemic stroke in patients with occlusive carotid artery diseases, called type 3 ischemia...
  37. Ameli P, Madan M, Chigurupati S, Yu A, Chan S, Pattisapu J. Effect of acetazolamide on aquaporin-1 and fluid flow in cultured choroid plexus. Acta Neurochir Suppl. 2012;113:59-64 pubmed publisher
    b>Acetazolamide (AZA), used in treatment of early or infantile hydrocephalus, is effective in some cases, while its effect on the choroid plexus (CP) remains ill-defined...
  38. Likitjaroen Y, Suwanwela N, Phanthumchinda K. Vasoreactivity induced by acetazolamide in patients with vascular dementia versus Alzheimer's disease. J Neurol Sci. 2009;283:32-5 pubmed publisher
    b>Acetazolamide vasoreactive test measures the increment of cerebral blood flow caused by compensatory vasodilatation ability of cerebral vessels which can be detected by transcranial Doppler ultrasound (TCD)...
  39. Lu N, Di Y, Feng X, Qiang J, Zhang J, Wang Y, et al. Comparison between acetazolamide challenge and 10% carbon dioxide challenge perfusion CT in rat C6 glioma. Acad Radiol. 2012;19:159-65 pubmed publisher
    The aim of this study was to investigate the effect of perfusion computed tomography (PCT) with acetazolamide (ACZ) challenge and compare it to 10% carbon dioxide (CO(2)) challenge in rat C6 glioma...
  40. Wolf A, Hutcheson K. Advances in evaluation and management of pediatric idiopathic intracranial hypertension. Curr Opin Ophthalmol. 2008;19:391-7 pubmed publisher
    ..The newer technologies allow us to gather data that may help to determine the optimal time for surgical intervention for those patients who require it. ..
  41. Kelly T, Hackett P. Acetazolamide and sulfonamide allergy: a not so simple story. High Alt Med Biol. 2010;11:319-23 pubmed publisher
    ..Cross-reactivity between the two groups has been implied in the past, but is suspect. Acetazolamide, from the nonantibiotic group, is routinely used in the prevention and treatment of high altitude issues and ..
  42. Fulesdi B, Szatmári S, Antek C, Fülep Z, Sárkány P, Csiba L, et al. Cerebral vasoreactivity to acetazolamide is not impaired in patients with severe sepsis. J Crit Care. 2012;27:337-43 pubmed publisher
    ..velocities were measured at rest and at 5, 10, 15, and 20 minutes after intravenous administration of 15 mg/kg acetazolamide. The time course of the acetazolamide effect on cerebral blood flow velocity (cerebrovascular reactivity [CVR])..
  43. Tachtsidis I, Tisdall M, Delpy D, Smith M, Elwell C. Measurement of cerebral tissue oxygenation in young healthy volunteers during acetazolamide provocation: a transcranial Doppler and near-infrared spectroscopy investigation. Adv Exp Med Biol. 2008;614:389-96 pubmed publisher
    ..this during a period of selective rise in cerebral blood flow (CBF) produced by the administration of acetazolamide (ACZ) in 10 healthy volunteers...
  44. Iannaccone A, Fung K, Eyestone M, Stone E. Treatment of adult-onset acute macular retinoschisis in enhanced s-cone syndrome with oral acetazolamide. Am J Ophthalmol. 2009;147:307-312.e2 pubmed publisher
    To report on the efficacy of the oral carbonic anhydrase inhibitor (CAI) acetazolamide in treating macular retinoschisis (RS) in the rare vitreoretinal dystrophy best known as the enhanced S-cone syndrome (ESCS)...
  45. Di Fiore A, Monti S, Hilvo M, Parkkila S, Romano V, Scaloni A, et al. Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. Proteins. 2009;74:164-75 pubmed publisher
    ..structure of this isozyme in the unbound state and in complex with a classical sulfonamide inhibitor, namely acetazolamide. A detailed comparison of the obtained structural data with those already reported for other CA isozymes ..
  46. Rim N, Kim H, Shin Y, Kim S. Which CT perfusion parameter best reflects cerebrovascular reserve?: correlation of acetazolamide-challenged CT perfusion with single-photon emission CT in Moyamoya patients. AJNR Am J Neuroradiol. 2008;29:1658-63 pubmed publisher
    ..Quantitative CVR was calculated by using normalized SPECT values before and after acetazolamide administration...
  47. Richalet J, Rivera Ch M, Maignan M, Privat C, Pham I, Macarlupu J, et al. Acetazolamide for Monge's disease: efficiency and tolerance of 6-month treatment. Am J Respir Crit Care Med. 2008;177:1370-6 pubmed publisher
    ..A preliminary study demonstrated the efficiency of acetazolamide (Acz) (250 mg/d for 3 wk) in reducing serum erythropoietin and hematocrit...
  48. Latshang T, Nussbaumer Ochsner Y, Henn R, Ulrich S, Lo Cascio C, Ledergerber B, et al. Effect of acetazolamide and autoCPAP therapy on breathing disturbances among patients with obstructive sleep apnea syndrome who travel to altitude: a randomized controlled trial. JAMA. 2012;308:2390-8 pubmed publisher
    ..The treatment in this setting is not established. To evaluate whether acetazolamide and autoadjusted continuous positive airway pressure (autoCPAP) control breathing disturbances in OSA patients ..
  49. Asiedu M, Ossipov M, Kaila K, Price T. Acetazolamide and midazolam act synergistically to inhibit neuropathic pain. Pain. 2010;148:302-8 pubmed publisher
    ..Here, we show that inhibition of spinal CA activity with acetazolamide (ACT) reduces neuropathic allodynia...
  50. Frydrychowski A, Wszedybyl Winklewska M, Bandurski T, Winklewski P. Flow-induced changes in pial artery compliance registered with a non-invasive method in rabbits. Microvasc Res. 2011;82:156-62 pubmed publisher
    ..blood volume fraction in the brain circulation (CBF(SDF)) and cc-TQ were recorded after glucagon and acetazolamide administration...
  51. Daugaard D, Thomsen L, Iversen H, Olesen J. Delayed migraine-like headache in healthy volunteers after a combination of acetazolamide and glyceryl trinitrate. Cephalalgia. 2009;29:1294-300 pubmed publisher
    ..GTN induces headache in healthy volunteers and migraine attacks in migraineurs. Acetazolamide (Az) increases CBF but does not dilate cerebral arteries...
  52. Szatmári S, Vegh T, Csomos A, Hallay J, Takacs I, Molnár C, et al. Impaired cerebrovascular reactivity in sepsis-associated encephalopathy studied by acetazolamide test. Crit Care. 2010;14:R50 pubmed publisher
    ..were measured at rest and at 5, 10, 15 and 20 minutes after intravenous administration of 15 mg/kgBW acetazolamide. The time course of the acetazolamide effect on cerebral blood flow velocity (cerebrovascular reactivity, CVR) ..
  53. Huang L, Yang Q, Zhang L, Chen X, Huang Q, Wang H. Acetazolamide improves cerebral hemodynamics in CADASIL. J Neurol Sci. 2010;292:77-80 pubmed publisher
    b>Acetazolamide (ACZ), a carbonic anhydrase inhibitor, causes a rapid increase in cerebral blood flow (CBF) in patients with cerebrovascular diseases...
  54. Kang K, Kim H, Kim S. Quantitative cerebrovascular reserve measured by acetazolamide-challenged dynamic CT perfusion in ischemic adult Moyamoya disease: initial experience with angiographic correlation. AJNR Am J Neuroradiol. 2008;29:1487-93 pubmed publisher
    ..We prospectively assessed quantitative cerebrovascular reserve by using acetazolamide (ACZ)-challenged CT perfusion for evaluating hemodynamic impairment in ischemic adult Moyamoya disease and ..
  55. Yonai Y, Boms N, Molnar S, Rosengarten B, Bornstein N, Csiba L, et al. Acetazolamide-induced vasodilation does not inhibit the visually evoked flow response. J Cereb Blood Flow Metab. 2010;30:516-21 pubmed publisher
    ..Our aim was to investigate whether the potent vasodilator agent, acetazolamide (AZ), inhibits the neurovascular coupling, which also requires vasodilation...
  56. Schuttelkopf A, Gros L, Blair D, Frearson J, van Aalten D, Gilbert I. Acetazolamide-based fungal chitinase inhibitors. Bioorg Med Chem. 2010;18:8334-40 pubmed publisher
    ..Here we explore acetazolamide as a chemical scaffold for the inhibition of an A. fumigatus 'plant-type' chitinase...
  57. Basnyat B, Holck P, Pun M, Halverson S, Szawarski P, Gertsch J, et al. Spironolactone does not prevent acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial by SPACE Trial Group (spironolactone and acetazolamide trial in the prevention of acute mountain sickness group). Wilderness Environ Med. 2011;22:15-22 pubmed publisher
    ..Hence, a prospective, double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy of spironolactone in the prevention of AMS...
  58. Alesutan I, Daryadel A, Mohebbi N, Pelzl L, Leibrock C, Voelkl J, et al. Impact of bicarbonate, ammonium chloride, and acetazolamide on hepatic and renal SLC26A4 expression. Cell Physiol Biochem. 2011;28:553-8 pubmed publisher
    ..Slc26a4 in liver and kidney of mice drinking tap water without or with NaHCO(3) (150 mM), NH(4)Cl (280 mM) or acetazolamide (3.6 mM) for seven days...
  59. Hartkamp N, Hendrikse J, van der Worp H, de Borst G, Bokkers R. Time course of vascular reactivity using repeated phase-contrast MR angiography in patients with carotid artery stenosis. Stroke. 2012;43:553-6 pubmed publisher
    ..was to assess the time course of the vasodilatory effect in the brain-feeding arteries after a challenge with acetazolamide in patients with a stenosis of the internal carotid artery (ICA)...
  60. Van Patot M, Leadbetter G, Keyes L, Maakestad K, Olson S, Hackett P. Prophylactic low-dose acetazolamide reduces the incidence and severity of acute mountain sickness. High Alt Med Biol. 2008;9:289-93 pubmed publisher
    Previous studies have shown low-dose acetazolamide to be effective in preventing AMS in persons already at high altitude and then moving higher, a relatively low risk situation...
  61. Huang S, Hainzl T, Grundström C, Forsman C, Samuelsson G, Sauer Eriksson A. Structural studies of ?-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide. PLoS ONE. 2011;6:e28458 pubmed publisher
    ..of the photoautotroph unicellular green alga Coccomyxa ?-CA in complex with five different inhibitors: acetazolamide, thiocyanate, azide, iodide, and phosphate ions...
  62. Mancino R, Varesi C, Cerulli A, Aiello F, Nucci C. Acute bilateral angle-closure glaucoma and choroidal effusion associated with acetazolamide administration after cataract surgery. J Cataract Refract Surg. 2011;37:415-7 pubmed publisher
    ..bilateral angle-closure glaucoma with extensive choroidal detachment following administration of oral acetazolamide immediately after routine cataract extraction and intraocular lens implantation...
  63. Farid K, Petras S, Ducasse V, Chokron S, Helft G, Blacher J, et al. Brain perfusion SPECT imaging and acetazolamide challenge in vascular cognitive impairment. Nucl Med Commun. 2012;33:571-80 pubmed publisher
    ..such as brain perfusion single-photon computed tomography, performed in baseline conditions and/or after an acetazolamide challenge, is underutilized in VCI exploration...
  64. Fogagnolo P, Centofanti M, Figus M, Frezzotti P, Fea A, Ligorio P, et al. Short-term changes in intraocular pressure after phacoemulsification in glaucoma patients. Ophthalmologica. 2012;228:154-8 pubmed
    ..pressure (IOP) changes after phacoemulsification in glaucoma and normal patients and the effect of oral acetazolamide (Diamox) to control IOP in these patients...
  65. Raurich J, Rialp G, Ibáñez J, Llompart Pou J, Ayestarán I. Hypercapnic respiratory failure in obesity-hypoventilation syndrome: CO? response and acetazolamide treatment effects. Respir Care. 2010;55:1442-8 pubmed
    ..relationship between CO? response, body mass index, and plasma bicarbonate concentration, and the effect of acetazolamide on bicarbonate concentration and CO? response...
  66. Matthews E, Portaro S, Ke Q, Sud R, Haworth A, Davis M, et al. Acetazolamide efficacy in hypokalemic periodic paralysis and the predictive role of genotype. Neurology. 2011;77:1960-4 pubmed publisher
    b>Acetazolamide has been the most commonly used treatment for hypokalemic periodic paralysis since 1968. However, its mechanism of efficacy is not fully understood, and it is not known whether therapy response relates to genotype...
  67. Nussbaumer Ochsner Y, Latshang T, Ulrich S, Kohler M, Thurnheer R, Bloch K. Patients with obstructive sleep apnea syndrome benefit from acetazolamide during an altitude sojourn: a randomized, placebo-controlled, double-blind trial. Chest. 2012;141:131-138 pubmed publisher
    ..Because the treatment of OSA at altitude has not been established, we tested the hypothesis that acetazolamide improves hypoxemia, sleep, and breathing disturbances in otherwise untreated patients with OSA at altitude...
  68. Ran X, Wang H, Chen Y, Zeng Z, Zhou Q, Zheng R, et al. Aquaporin-1 expression and angiogenesis in rabbit chronic myocardial ischemia is decreased by acetazolamide. Heart Vessels. 2010;25:237-47 pubmed publisher
    ..These AQP1-induced changes were tempered by acetazolamide, a carbonic anhydrase inhibitor, which acted by downregulating AQP1 expression...
  69. Tanimura Y, Hiroaki Y, Fujiyoshi Y. Acetazolamide reversibly inhibits water conduction by aquaporin-4. J Struct Biol. 2009;166:16-21 pubmed publisher
    ..Here, we report the effect of inhibitors on water conduction by AQP4 and AQP1 reconstituted into liposomes. Acetazolamide (AZA), an inhibitor of sulfonamide carbonic anhydrase (CA), reversibly inhibits water permeation through AQP4, ..