Treponema pallidum

Summary

Alias: "Microspironema pallidum" (Schaudinn and Hoffmann 1905) Stiles and Pfender 1905, "Spirillum pallidum" (Schaudinn and Hoffmann 1905) Mace 1913, "Spirochaeta pallida" Schaudinn and Hoffmann 1905, "Spironema pallidum" (Schaudinn and Hoffmann 1905) Vuillemin 1905, Microspironema pallidum, Spirillum pallidum, Spirochaeta pallida, Spironema pallidum, Treponema pallidum (Schaudinn and Hoffmann 1905) Schaudinn 1905

Top Publications

  1. Calvet G, Aguiar R, Melo A, Sampaio S, de Filippis I, Fabri A, et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. 2016;16:653-660 pubmed publisher
    ..virus, chikungunya virus, Toxoplasma gondii, rubella virus, cytomegalovirus, herpes simplex virus, HIV, Treponema pallidum, and parvovirus B19 were all negative...
  2. Gaydos C, Rizzo Price P, Balakrishnan P, Mateta P, Leon S, Verevochkin S, et al. Impact of international laboratory partnerships on the performance of HIV/sexually transmitted infection testing in five resource-constrained countries. Int J STD AIDS. 2011;22:645-52 pubmed publisher
    ..assays, herpes simplex virus type 2 enzyme immunoassay (EIA), syphilis serology (rapid plasma regain and Treponema pallidum particle agglutination assay, HIV serology (EIA/Western blot) and Trichomonas vaginalis culture...
  3. Sánchez Montalvá A, Salvador F, Ruiz Camps I, Barba P, Valcarcel D, Sulleiro E, et al. Imported Disease Screening Prior to Chemotherapy and Bone Marrow Transplantation for Oncohematological Malignancies. Am J Trop Med Hyg. 2016;95:1463-1468 pubmed
    ..Patients were tested for soil-transmitted helminths, hepatitis virus, and human immunodeficiency virus, Treponema pallidum, human T-cell lymphotropic virus, latent tuberculosis infection, Toxoplasma spp...
  4. Nenoff P, Manos A, Ehrhard I, Kruger C, Paasch U, Helmbold P, et al. [Nonviral sexually transmitted infections-epidemiology, clinical manifestations, diagnostic workup, therapy : Part 3: Treponemes, Gardnerella and trichomonads]. Hautarzt. 2017;68:136-148 pubmed publisher
    ..There are no penicillin-resistant Treponema pallidum strains. Alternatives are ceftriaxone and doxycycline...
  5. Liu J, Liu W, Liu Y, Zhou X, Zhang Z, Sun Z. Prevalence of microorganisms co-infections in human papillomaviruses infected women in Northern China. Arch Gynecol Obstet. 2016;293:595-602 pubmed publisher
    ..of serological markers for human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV) and Treponema pallidum infections...
  6. Barnabas S, Dabee S, Passmore J, Jaspan H, Lewis D, Jaumdally S, et al. Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV. Int J STD AIDS. 2017;:956462417740487 pubmed publisher
    ..Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, herpes simplex virus (HSV)-1, HSV-2, Treponema pallidum, and Haemophilus ducreyi) were detected by multiplex polymerase chain reaction, human papillomavirus (HPV) ..
  7. Chen S, Zhang X, Chen Z, Wang W, Li Y, Li C, et al. Mutual blood donation is safer at small blood collection stations in China. Transfus Apher Sci. 2015;53:315-9 pubmed publisher
    ..antibodies against hepatitis C virus (anti-HCV), human immunodeficiency virus (anti-HIV) (1 + 2) and Treponema pallidum (anti-TP) by the enzyme immunoassays (EIAs), and alanine aminotransferase (ALT) in the Center Blood Station ..
  8. Benvenga S, Guarneri F. Molecular mimicry and autoimmune thyroid disease. Rev Endocr Metab Disord. 2016;17:485-498 pubmed publisher
    ..pathogenic importance of Toxoplasma gondii, some Bifidobacteria and Lactobacilli, Candida albicans, Treponema pallidum and hepatitis C virus in autoimmune thyroid disease, indicating specific molecular targets for future ..
  9. Gimenes F, Souza R, Bento J, Teixeira J, Maria Engler S, Bonini M, et al. Male infertility: a public health issue caused by sexually transmitted pathogens. Nat Rev Urol. 2014;11:672-87 pubmed publisher
    ..b>Treponema pallidum and Trichomonas vaginalis, because few studies have evaluated the influence of these pathogens on male ..

More Information

Publications169 found, 100 shown here

  1. Park J, Seo Y, Jeong S, Lee J. Prevalence of and Risk Factors for Sexually Transmitted Infections among Korean Adolescents under Probation. J Korean Med Sci. 2017;32:1771-1778 pubmed publisher
    ..gonorrhoeae, Trichomonas vaginalis, herpes simplex virus (HSV), human immunodeficiency virus (HIV), Treponema pallidum, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum, and Ureaplasma parvum...
  2. Tiittala P, Ristola M, Liitsola K, Ollgren J, Koponen P, Surcel H, et al. Missed hepatitis b/c or syphilis diagnosis among Kurdish, Russian, and Somali origin migrants in Finland: linking a population-based survey to the national infectious disease register. BMC Infect Dis. 2018;18:137 pubmed publisher
    ..Seroprevalence of hepatitis B surface antigen (HBsAg) was 2.3%, hepatitis C antibodies 1.7%, and Treponema pallidum antibodies 1.3%. No cases of HIV were identified...
  3. Lobo A, Gao Y, Rusie L, Houlberg M, Mehta S. Association between eye diagnosis and positive syphilis test results in a large, urban sexually transmitted infection/primary care clinic population. Int J STD AIDS. 2017;:956462417726700 pubmed publisher
    ..immunoassay [EIA], rapid plasma reagin [RPR] titer, fluorescent treponemal antibody absorption [FTA-Abs], Treponema pallidum Ab). Multivariable logistic regression with robust variance was used to identify independent associations...
  4. Yoshikawa K, Aida Y, Seki N, Miyazaki T, Itagaki M, Ishiguro H, et al. Early syphilitic hepatitis concomitant with nephrotic syndrome followed by acute kidney injury. Clin J Gastroenterol. 2014;7:349-54 pubmed publisher
    ..The rapid plasmin regain test and Treponema pallidum hemagglutination assay were positive, supporting the presence of a syphilis infection...
  5. Duarte J, Henriques C, Sousa C, Alves J. Lupus or syphilis? That is the question!. BMJ Case Rep. 2015;2015: pubmed publisher
    ..Laboratory investigations revealed a venereal disease research laboratory (VDRL) titre of 1/4 and Treponema pallidum haemagluttin antigen (TPHA) of 1/640, positive anti-nuclear antibodies of 1/640 and nephrotic proteinuria (3...
  6. Kriesel J, Bhatia A, Barrus C, Vaughn M, Gardner J, Crisp R. Multiplex PCR testing for nine different sexually transmitted infections. Int J STD AIDS. 2016;27:1275-1282 pubmed
    ..PCR primer sets for each organism was designed to detect Chlamydia trachomatis, Neisseria gonorrhoeae, Treponema pallidum, Trichomonas vaginalis, Mycoplasma genitalium, Ureaplasma urealyticum, Haemophilus ducreyi, and herpes ..
  7. Komeno Y, Ota Y, Koibuchi T, Imai Y, Iihara K, Ryu T. Secondary Syphilis with Tonsillar and Cervical Lymphadenopathy and a Pulmonary Lesion Mimicking Malignant Lymphoma. Am J Case Rep. 2018;19:238-243 pubmed
    BACKGROUND Syphilis is a sexually transmitted disease caused by the pathogen Treponema pallidum. Prevalence continues to rise, especially among men who have sex with men (MSM)...
  8. Njiru E, Abdulkadir J, Kamuren Z, Kigen G. Early neurosyphilis presenting with facial palsy and an oral ulcer in a patient who is human immunodeficiency virus positive: a case report. J Med Case Rep. 2017;11:134 pubmed publisher
    Neurosyphilis is the tertiary stage of Treponema pallidum infection that involves the central nervous system, which occurs within days or weeks after an initial syphilis infection, especially in immunocompromised patients...
  9. Endris M, Deressa T, Belyhun Y, Moges F. Seroprevalence of syphilis and human immunodeficiency virus infections among pregnant women who attend the University of Gondar teaching hospital, Northwest Ethiopia: a cross sectional study. BMC Infect Dis. 2015;15:111 pubmed publisher
    ..Sera against syphilis were screened by rapid plasma reagin test; and confirmed by Treponema pallidum hemagglutination assay...
  10. Jansen K, Thamm M, Bock C, Scheufele R, Kücherer C, Muenstermann D, et al. High Prevalence and High Incidence of Coinfection with Hepatitis B, Hepatitis C, and Syphilis and Low Rate of Effective Vaccination against Hepatitis B in HIV-Positive Men Who Have Sex with Men with Known Date of HIV Seroconversion in Germany. PLoS ONE. 2015;10:e0142515 pubmed publisher
    ..2%, respectively, and 47.5% had been effectively vaccinated against HBV. Prevalence of antibodies to Treponema pallidum and of triple or quadruple sexually transmitted infections (STIs) were 39.6% and 18.9%, respectively...
  11. Cunha C, Friedman R, De Boni R, Gaydos C, Guimarães M, Siqueira B, et al. Chlamydia trachomatis, Neisseria gonorrhoeae and syphilis among men who have sex with men in Brazil. BMC Public Health. 2015;15:686 pubmed publisher
    ..The rapid plasma reagin test and microhemagglutination assay for Treponema pallidum were performed for syphilis diagnosis. The overall prevalence of STD was 20.0% (95%CI:15.7-25...
  12. Marangoni A, Foschi C, Capretti M, Nardini P, Compri M, Corvaglia L, et al. Contribution of a Comparative Western Blot Method to Early Postnatal Diagnosis of Congenital Syphilis. Clin Vaccine Immunol. 2016;23:410-416 pubmed publisher
    ..between passively transmitted maternal antibodies and antibodies synthesized by the infants against Treponema pallidum Thirty infants born to mothers with unknown or inadequate treatment for syphilis were entered in a ..
  13. Lagier J, Edouard S, Pagnier I, Mediannikov O, Drancourt M, Raoult D. Current and past strategies for bacterial culture in clinical microbiology. Clin Microbiol Rev. 2015;28:208-36 pubmed publisher
    ..Nevertheless, among usual bacterial pathogens, the development of axenic media for the culture of Treponema pallidum or Mycobacterium leprae remains an important challenge that the patience and innovations of cultivators will ..
  14. Janier M, Hegyi V, Dupin N, Unemo M, Tiplica G, Potočnik M, et al. 2014 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2014;28:1581-93 pubmed publisher
    ..Major advances include (1) broader use of PCR, immunohistochemistry, subtyping of the etiological agent Treponema pallidum subspecies pallidum, new treponemal tests, and rapid-point-of-care (POC) tests detecting both treponemal and ..
  15. Chu C, Chen W, Yeh S, Yeh H, Fang C. Syphilitic orchitis mimicking a testicular tumor in a clinically occult HIV-infected young man: a case report with emphasis on a challenging pathological diagnosis. Diagn Pathol. 2016;11:4 pubmed publisher
    ..Syphilitic orchitis was confirmed by both an immunohistochemical study and PCR testing for the Treponema pallidum DNA polymerase I gene using paraffin-embedded tissues...
  16. Okoroiwu H, Okafor I, Asemota E, Okpokam D. Seroprevalence of transfusion-transmissible infections (HBV, HCV, syphilis and HIV) among prospective blood donors in a tertiary health care facility in Calabar, Nigeria; an eleven years evaluation. BMC Public Health. 2018;18:645 pubmed publisher
    ..antigen (HBsAg), antibodies to hepatitis C virus (HCV), human immunodeficiency virus (HIV) 1 and 2 and Treponema pallidum using commercially available immunochromatic based kits...
  17. Kassem Youssef H, Blind A, Chouta Ngaha F, Drenou B, Nojavan H, Michel C. Secondary pulmonary syphilis: Case report and review of literature. Ann Dermatol Venereol. 2018;145:278-287 pubmed publisher
    ..HIV co-infection was declared in 5 cases. Treponema pallidum was found in 6 patients using PCR on bronchoalveolar lavage (BAL) (3 patients) or on a lung biopsy (1Â..
  18. Tiittala P, Tuomisto K, Puumalainen T, Lyytikainen O, Ollgren J, Snellman O, et al. Public health response to large influx of asylum seekers: implementation and timing of infectious disease screening. BMC Public Health. 2018;18:1139 pubmed publisher
    ..4% [95% CI 1.3-1.6%], HIV 0.3% [95% CI 0.1-0.4%] and Treponema pallidum specific antibodies 1.0% [95% CI 0.8-1.1%]...
  19. García Bermejo I, de Ory Manchón F. [Serological diagnosis of congenital infections and algorithms to improve diagnostic efficacy]. Enferm Infecc Microbiol Clin. 2015;33 Suppl 2:20-6 pubmed publisher
    ..simplex, varicella-zoster, hepatitis B and C virus, human inunodeficiencia, erythrovirus B19) as bacteria (Treponema pallidum) and parasites (Toxoplasma gondii and Trypanosoma cruzi)...
  20. Yamada H, Tairaku S, Morioka I, Sonoyama A, Tanimura K, Deguchi M, et al. Nationwide survey of mother-to-child infections in Japan. J Infect Chemother. 2015;21:161-4 pubmed publisher
    ..infections for 34 cases with cytomegalovirus (CMV), 1 with Toxoplasma gondii, 4 with rubella virus, 5 with Treponema pallidum, 8 with herpes simplex virus, and 69 with parvovirus B19 was confirmed after questionnaire assessment...
  21. Lin S, Li R, Huang S, Zhao L, Li M, Li J, et al. Evaluation of syphilis serostatus on the safety of IVF treatment. Reprod Biomed Online. 2014;29:756-60 pubmed publisher
    ..50% ± 17.57%/78.72% ± 16.66% in the Treponema pallidum particle agglutination assay negative (TPPA-negative) and rapid plasma reagin negative (RPR-negative) group, ..
  22. Bannantine J, Rockey D. Use of primate model system to identify Chlamydia trachomatis protein antigens recognized uniquely in the context of infection. Microbiology. 1999;145 ( Pt 8):2077-85 pubmed
    ..The fourth clone contains two complete ORFs, each encoding 32 kDa proteins that share identity with Treponema pallidum TroA and TroB (ORFs D067 and D068 in the C. trachomatis database, respectively)...
  23. Talha S, Saviranta P, Hattara L, Vuorinen T, Hytönen J, Khanna N, et al. Array-in-well platform-based multiplex assay for the simultaneous detection of anti-HIV- and treponemal-antibodies, and Hepatitis B surface antigen. J Immunol Methods. 2016;429:21-7 pubmed publisher
    ..We have developed a single-step AIW assay for the simultaneous screening of HIV, Treponema pallidum subspecies pallidum (causing syphilis) and Hepatitis B virus infections targeting the specific detection of ..
  24. Zhang Y, Wang Q, Liu M, Shen H, Ma X, Zhang M, et al. [Status assessment of preconception health risk exposure among 2 030 083 males in 31 provinces during 2010-2012]. Zhonghua Yi Xue Za Zhi. 2015;95:176-80 pubmed
    ..HBsAg positive rate was 6.32% (124 274/1 965 821). And the positive screening rate of Treponema pallidum was 0.37% (7 169/1 947 021)...
  25. Tanaka M, Okamoto M, Murayama T. A case of acute myocardial infarction due to cardiovascular syphilis with aortic regurgitation and bilateral coronary ostial stenosis. Surg Case Rep. 2016;2:138 pubmed
    ..On arrival, rapid plasma reagin and Treponema pallidum hemagglutination tests were 172.2- and 1187.5-fold, respectively...
  26. Peng X, Knouse J, Hernon K. Rabbit Models for Studying Human Infectious Diseases. Comp Med. 2015;65:499-507 pubmed
    ..stromal keratitis (herpes simplex virus type 1), tuberculosis (Mycobacterium tuberculosis), and syphilis (Treponema pallidum)...
  27. Cristillo A, Bristow C, Peeling R, Van Der Pol B, de Cortina S, Dimov I, et al. Point-of-Care Sexually Transmitted Infection Diagnostics: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. Sex Transm Dis. 2017;44:211-218 pubmed publisher
    ..STIs such as Chlamydia trachomatis, human papillomavirus, Neisseria gonorrhoeae, Trichomonas vaginalis, and Treponema pallidum. Key objectives included a review of current and emerging technologies, clinical and public health benefits, ..
  28. Böer Auer A. [Relevance of biopsies for the diagnostics of infectious skin diseases]. Hautarzt. 2018;69:550-562 pubmed publisher
    ..and Grocott for hyphae and spores, Ziehl-Neelson and Fite-Faraco for Mycobacteria or specific antibodies for Treponema pallidum or herpesviruses...
  29. Sampedro Martínez A, Padilla Malo A, Gómez Camarasa C, Rodriguez Granger J, Lara Oya A. Evaluation of a new chemiluminescence immunoassay for laboratory diagnosis of syphilis. J Microbiol Methods. 2013;94:133-134 pubmed publisher
    ..was to evaluate diagnostic performances of automated chemiluminescence immunoassay (CLIA) in comparison with Treponema pallidum hemagglutination test (TPHA). The specificity of CLIA was 98.9% and 99...
  30. Prinja A, Roberts C, Doherty T, Oddy M. An unusual cause of an ankle mass. BMJ Case Rep. 2014;2014: pubmed publisher
    ..An initial diagnosis of endemic syphilis was made after treponemal antibody and treponema pallidum particle agglutination tests were positive...
  31. Marks M, Vahi V, Sokana O, Puiahi E, Pavluck A, Zhang Z, et al. Mapping the epidemiology of yaws in the Solomon Islands: a cluster randomized survey. Am J Trop Med Hyg. 2015;92:129-33 pubmed publisher
    ..4%) had evidence of healed yaws lesions. Four hundred and seventy (470) (31.4%) children had a positive Treponema pallidum particle agglutination assay (TPPA)...
  32. Gayet Ageron A, Laurent F, Schrenzel J, Charton B, Jimenez Getaz G, Tangomo M, et al. Performance of the 47-kilodalton membrane protein versus DNA polymerase I genes for detection of Treponema pallidum by PCR in ulcers. J Clin Microbiol. 2015;53:976-80 pubmed publisher
    b>Treponema pallidum PCR (Tp-PCR) is a direct diagnostic method for primary and secondary syphilis, but there is no recommendation regarding the best choice of target gene...
  33. Anand A, Ledoyt M, Karanian C, Luthra A, Koszelak Rosenblum M, Malkowski M, et al. Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN. J Biol Chem. 2015;290:12313-31 pubmed publisher
    We previously identified Treponema pallidum repeat proteins TprC/D, TprF, and TprI as candidate outer membrane proteins (OMPs) and subsequently demonstrated that TprC is not only a rare OMP but also forms trimers and has porin activity...
  34. Houston S, Taylor J, Denchev Y, Hof R, Zuerner R, Cameron C. Conservation of the Host-Interacting Proteins Tp0750 and Pallilysin among Treponemes and Restriction of Proteolytic Capacity to Treponema pallidum. Infect Immun. 2015;83:4204-16 pubmed publisher
    The spirochete Treponema pallidum subsp. pallidum is the causative agent of syphilis, a chronic, sexually transmitted infection characterized by multiple symptomatic and asymptomatic stages...
  35. Wang K, Xu D, Su J. Preferable procedure for the screening of syphilis in clinical laboratories in China. Infect Dis (Lond). 2016;48:26-31 pubmed publisher
    ..assay was conducted on 3962 serum samples tested by CLIA, rapid plasma reagin test (RPR), and Treponema pallidum particle agglutination (TPPA)...
  36. Salado Rasmussen K. Syphilis and HIV co-infection. Epidemiology, treatment and molecular typing of Treponema pallidum. Dan Med J. 2015;62:B5176 pubmed
    The studies included in this PhD thesis examined the interactions of syphilis, which is caused by Treponema pallidum, and HIV...
  37. Ampah K, Nickel B, Asare P, Ross A, De Graft D, Kerber S, et al. A Sero-epidemiological Approach to Explore Transmission of Mycobacterium ulcerans. PLoS Negl Trop Dis. 2016;10:e0004387 pubmed publisher
    ..Further results from our serological investigations in the Offin river valley also indicate ongoing transmission of Treponema pallidum, the causative agent of yaws.
  38. Kremastinou J, Polymerou V, Lavranos D, Aranda Arrufat A, Harwood J, Martínez Lorenzo M, et al. Evaluation of Elecsys Syphilis Assay for Routine and Blood Screening and Detection of Early Infection. J Clin Microbiol. 2016;54:2330-6 pubmed publisher
    b>Treponema pallidum infections can have severe complications if not diagnosed and treated at an early stage. Screening and diagnosis of syphilis require assays with high specificity and sensitivity...
  39. Eirin M, Delfino C, Pedrozo W, Malan R, Puca A, de Rissio A, et al. Health care importance of Treponema pallidum, Chagas' disease and Human immunodeficiency virus 1 among Amerindians of Argentina: an observational study. Rev Argent Microbiol. 2017;49:315-319 pubmed publisher
    The objective of this study was to estimate the prevalence of Treponema pallidum, Trypanosoma cruzi and Human immunodeficiency virus 1 (HIV-1) in five Amerindian populations of Argentina...
  40. Graham R, Naini B, Shah S, Arnold C, Kannangai R, Torbenson M, et al. Treponema pallidum Immunohistochemistry is positive in human intestinal Spirochetosis. Diagn Pathol. 2018;13:7 pubmed publisher
    ..We evaluated the Treponema pallidum immunostain as a diagnostic adjunct for IS. We retrieved biopsies from 33 patients with IS for this study...
  41. Lin L, Xiao Y, Liu W, Chen Y, Zhu X, Gao Z, et al. Development of tissue inflammation accompanied by NLRP3 inflammasome activation in rabbits infected with Treponema pallidum strain Nichols. BMC Infect Dis. 2018;18:101 pubmed publisher
    The inflammasome responses in Treponema pallidum infection have been poorly understood to date...
  42. Lin L, Gao Z, Lin Y, Zhu X, Liu W, Liu D, et al. Akt, mTOR and NF-?B pathway activation in Treponema pallidum stimulates M1 macrophages. Int Immunopharmacol. 2018;59:181-186 pubmed publisher
    ..This study was conducted to explore the influence of Treponema pallidum (T...
  43. Liang X, Liu T, Yuan C, Wang W, Liang P. The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review. BMC Musculoskelet Disord. 2018;19:251 pubmed publisher
    b>Treponema Pallidum (TP), the pathogen of syphilis, commonly infects bones in cases of congenital and tertiary syphilis, but it is rare in the primary and secondary stages...
  44. Lukehart S. New Tools for Syphilis Research. MBio. 2018;9: pubmed publisher
    Syphilis research has been severely limited by the necessity to propagate Treponema pallidumin vivo in rabbits. After decades of erroneous or irreproducible reports of cultivation of T...
  45. Chi K, Danavall D, Taleo F, Pillay A, Ye T, Nachamkin E, et al. Molecular differentiation of Treponema pallidum subspecies in skin ulceration clinically suspected as yaws in Vanuatu using real-time multiplex PCR and serological methods. Am J Trop Med Hyg. 2015;92:134-8 pubmed publisher
    We developed a TaqMan-based real-time quadriplex polymerase chain reaction (PCR) to simultaneously detect Treponema pallidum subspecies pallidum, T. pallidum subsp. pertenue, and T. pallidum subsp...
  46. Li Z, Li D, Liu H, Jiang Z, Zhu L, Wang N. [Study on the prevalence and associated risk factors related to HIV, syphilis, herpes simplex virus-2 among female sex workers in Jiaozhou, Shandong province]. Zhonghua Liu Xing Bing Xue Za Zhi. 2014;35:1099-104 pubmed
    ..Patients with positive results from both treponema pallidum and HSV-2 tested by ELISA method, were defined as being superinfected...
  47. Steinberg R. Robert Schumann in the psychiatric hospital at Endenich. Prog Brain Res. 2015;216:233-75 pubmed publisher
    ..Proof of the Treponema pallidum infection and the serologic reaction is not obtained until 1906...
  48. An J, Chen Q, Liu Q, Rao C, Li D, Wang T, et al. Evaluation of the HISCL Anti-Treponema pallidum Assay as a Screening Test for Syphilis. Clin Vaccine Immunol. 2015;22:817-22 pubmed publisher
    ..a serious threat to public health worldwide, and the serological detection of specific antibodies against Treponema pallidum remains the most reliable method for laboratory diagnosis of syphilis...
  49. Gangaiah D, Webb K, Humphreys T, Fortney K, Toh E, Tai A, et al. Haemophilus ducreyi Cutaneous Ulcer Strains Are Nearly Identical to Class I Genital Ulcer Strains. PLoS Negl Trop Dis. 2015;9:e0003918 pubmed publisher
    Although cutaneous ulcers (CU) in the tropics is frequently attributed to Treponema pallidum subspecies pertenue, the causative agent of yaws, Haemophilus ducreyi has emerged as a major cause of CU in yaws-endemic regions of the South ..
  50. Huang N, Ye L, Schneider M, Du Y, Xu Y, Fan L, et al. Development of a novel protein biochip enabling validation of immunological assays and detection of serum IgG and IgM antibodies against Treponema pallidum pathogens in the patients with syphilis. Biosens Bioelectron. 2016;75:465-71 pubmed publisher
    ..succinimidyl undecanoate) (DSU) and specialized for detection of serum IgG and IgM antibodies against Treponema pallidum pathogens in the patients with syphilis, respectively...
  51. Merins V, Hahn K. Syphilis and neurosyphilis: HIV-coinfection and value of diagnostic parameters in cerebrospinal fluid. Eur J Med Res. 2015;20:81 pubmed publisher
    ..neurosyphilis were applicable were further analyzed for clinical symptoms, CSF, HIV-status as well as Treponema pallidum testing in serum and CSF...
  52. Leon S, Ramos L, Vargas S, Kojima N, Perez D, Caceres C, et al. Laboratory Evaluation of a Dual-Path Platform Assay for Rapid Point-of-Care HIV and Syphilis Testing. J Clin Microbiol. 2016;54:492-4 pubmed publisher
    ..dual-path platform HIV-syphilis rapid immunodiagnostic test and electronic reader for detection of HIV and Treponema pallidum antibodies in 450 previously characterized serum specimens...
  53. Castro R, Águas M, Batista T, Araújo C, Mansinho K, Pereira F. Detection of Treponema pallidum Sp. Pallidum DNA in Cerebrospinal Fluid (CSF) by Two PCR Techniques. J Clin Lab Anal. 2016;30:628-32 pubmed publisher
    ..no single laboratory test result being appropriate to diagnose central nervous system infectivity caused by Treponema pallidum. Our objective was to evaluate two polymerase chain reaction (PCR) techniques for the detection of T...
  54. Mitjà O, González Beiras C, Godornes C, Kolmau R, Houinei W, Abel H, et al. Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study. Lancet Glob Health. 2017;5:e1268-e1274 pubmed publisher
    ..Latent yaws was defined as lack of suspicious skin lesions or presence of ulcers negative for Treponema pallidum subsp pertenue on PCR, and active yaws was defined as ulcers positive for T pertenue on PCR...
  55. Picard C, Fontaine J, Chouvet B, Balme B, Traverse Glehen A. [The key role of the pathologist in the diagnosis of syphilis: A case report]. Ann Pathol. 2017;: pubmed publisher
    Syphilis is a resurging sexually transmitted infection linked to Treponema Pallidum. Syphilitic lymphadenitis can be present during the 3 stages of the disease...
  56. Gao N, Huang L, Wang R, Jia J, Wu S, Zhang J, et al. [Evaluation of the Performance of Two Kinds of Anti-TP Enzyme-Linked Immunosorbent Assay]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26:905-910 pubmed publisher
    To evaluate the accuracy and precision of 2 kinds of anti-treponema pallidum (anti-TP) ELISA reagents in our laboratory for detecting the anti-TP in voluntary blood donors, so as to provide the data support for use of ELISA reagents after ..
  57. Sönmez C, Demir T, Uzunmehmetoglu T, Maden H, Kilic S. Serological Diagnosis of Syphilis: Preliminary Study Searching for an Algorhitm in Turkey. Acta Dermatovenerol Croat. 2018;26:146-152 pubmed
    ..preliminary diagnosis and were positive on at least one of the following tests: Rapid Plasma Reagin (RPR), Treponema pallidum Haemagglutination test (TPHA) and FTA-abs Ig...
  58. Yang C, Tang H, Chang S, Hsieh S, Lee K, Lee Y, et al. Comparison of serological responses to single-dose azithromycin (2 g) versus benzathine penicillin G in the treatment of early syphilis in HIV-infected patients in an area of low prevalence of macrolide-resistant Treponema pallidum infection. J Antimicrob Chemother. 2016;71:775-82 pubmed publisher
    ..Genotypic resistance to macrolides was determined in Treponema pallidum isolates identified from clinical specimens using PCR assays...
  59. Xu M, Xie Y, Jiang C, Xiao Y, Kuang X, Zhao F, et al. A novel ELISA using a recombinant outer membrane protein, rTp0663, as the antigen for serological diagnosis of syphilis. Int J Infect Dis. 2016;43:51-57 pubmed publisher
    The lack of Treponema pallidum-specific antigens with highly accurate diagnosis makes the diagnosis of syphilis challenging. A soluble recombinant version of a new diagnostic protein Tp0663 has been produced...
  60. Marra C. Other central nervous system infections: cytomegalovirus, Mycobacterium tuberculosis, and Treponema pallidum. Handb Clin Neurol. 2018;152:151-166 pubmed publisher
    ..polyradiculomyelitis; Mycobacterium tuberculosis, which can cause meningitis or space-occupying lesions; and Treponema pallidum subspecies pallidum (T...
  61. Cao W, Zhou R, Ou X, Shi L, Xiao C, Chen T, et al. Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016. BMC Infect Dis. 2018;18:145 pubmed publisher
    Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Treponema pallidum (TP) infections are considered classic transfusion-transmissible infections (TTIs)...
  62. Xie M, Zhou J, Wang Y. [Monitoring of hematogenous occupational exposure in medical staff in infectious disease hospital]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015;33:766-8 pubmed
    ..3%, 72.1%, and 72.2%, respectively. Hepatitis B virus, hepatitis C virus, Treponema pallidum, and human immunodeficiency virus were the primary exposure sources...
  63. Hussein K, Peter C, Sedlacek L, Kaisenberg C, Kreipe H. [Necrotizing funisitis : Histopathological indicator of occult congenital syphilis]. Pathologe. 2017;38:312-316 pubmed publisher
    ..incidental finding of B lymphocyte-rich, necrotizing funisitis led to the diagnosis of a previously unknown Treponema pallidum infection in parents and their newborn child...
  64. Kinikar A, Gupte N, Bhat J, Bharadwaj R, Kulkarni V, Bhosale R, et al. Maternal Syphilis: An Independent Risk Factor for Mother to Infant Human Immunodeficiency Virus Transmission. Sex Transm Dis. 2017;44:371-375 pubmed publisher
    ..Maternal syphilis, diagnosed serologically using Venereal Disease Research Laboratory titer plus Treponema Pallidum Hemagglutination Assay, was associated with 2.5-fold greater risk.
  65. Pozzobon T, Facchinello N, Bossi F, Capitani N, Benagiano M, Di Benedetto G, et al. Treponema pallidum (syphilis) antigen TpF1 induces angiogenesis through the activation of the IL-8 pathway. Sci Rep. 2016;6:18785 pubmed publisher
    Over 10 million people every year become infected by Treponema pallidum and develop syphilis, a disease with broad symptomatology that, due to the difficulty to eradicate the pathogen from the highly vascularized secondary sites of ..
  66. Xiao Y, Tong M, Lin L, Liu L, Gao K, Chen M, et al. Serological Response Predicts Normalization of Cerebrospinal Fluid Abnormalities at Six Months after Treatment in HIV-Negative Neurosyphilis Patients. Sci Rep. 2017;7:9911 pubmed publisher
    ..Before treatment, the CSF rapid plasma reagin (RPR) titer, CSF Treponema pallidum particle agglutination (TPPA) titer, CSF leukocyte count, and CSF protein concentration were correlated with ..
  67. Singer M, Ouburg S. Effect of cytokine level variations in individuals on the progression and outcome of bacterial urogenital infections--a meta-analysis. Pathog Dis. 2016;74: pubmed publisher
    ..For Treponema pallidum infection, it was shown that IFNγ variation in hosts could be linked to severity of disease...
  68. Amsalu A, Ferede G, Assegu D. High seroprevalence of syphilis infection among pregnant women in Yiregalem hospital southern Ethiopia. BMC Infect Dis. 2018;18:109 pubmed publisher
    ..for syphilis using rapid plasma regain (RPR) test and those found seropositive were further confirmed by Treponema pallidum haemagglutination assay (TPHA) test following the manufacturer's instruction...
  69. Simčič S, Potočnik M. Serological diagnosis of syphilis: a comparison of different diagnostic methods. Acta Dermatovenerol Alp Pannonica Adriat. 2015;24:17-20 pubmed
    ..a total of 437 clinical serum samples from adults throughout Slovenia tested with Rapid Plasma Reagin (RPR), Treponema pallidum hemagglutination (TPHA), and an automated chemiluminescence immunoassay (CIA) according to the manufacturer'..
  70. Jonckheere S, Berth M, Van Esbroeck M, Blomme S, Lagrou K, Padalko E. Evaluation of different confirmatory algorithms using seven treponemal tests on Architect Syphilis TP-positive/RPR-negative sera. Eur J Clin Microbiol Infect Dis. 2015;34:2041-8 pubmed publisher
    ..Transmitted Infections (IUSTI) 2014 guidelines, however, positive screening tests need confirmation with Treponema pallidum particle agglutination (TP.PA)...
  71. Moura A, de Mello M, Correia J. Prevalence of syphilis, human immunodeficiency virus, hepatitis B virus, and human T-lymphotropic virus infections and coinfections during prenatal screening in an urban Northeastern Brazilian population. Int J Infect Dis. 2015;39:10-5 pubmed publisher
    To evaluate prevalences of Treponema pallidum, human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), and hepatitis B virus (HBV) infections and coinfections during prenatal screening in an urban Northeastern Brazilian ..
  72. Šmajs D, Paštěková L, Grillová L. Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains?. Am J Trop Med Hyg. 2015;93:678-83 pubmed publisher
    b>Treponema pallidum ssp. pallidum (TPA) causes over 10 million new cases of syphilis worldwide whereas T. pallidum ssp. pertenue (TPE), the causative agent of yaws, affects about 2.5 million people...
  73. Song X, Tian L, Zou H, Sun H. Analysis of the clinical diagnosis data of four experimental detection methods for pediatric syphilis. Minerva Pediatr. 2015;: pubmed
    ..reagin (RPR) test, the colloidal gold test (SYP), the enzyme-linked immuno-sorbent assay (ELISA) and the Treponema pallidum particle agglutination (TPPA) test. The relevant experimental data were analyzed by SPSS 13.0 software...
  74. Å majs D, Strouhal M, Knauf S. Genetics of human and animal uncultivable treponemal pathogens. Infect Genet Evol. 2018;61:92-107 pubmed publisher
    b>Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. endemicum)...
  75. Sommese L, Paolillo R, Sabia C, Costa D, De Pascale M, Iannone C, et al. Syphilis detection: evaluation of serological screening and pilot reverse confirmatory assay algorithm in blood donors. Int J STD AIDS. 2016;27:644-9 pubmed publisher
    ..To confirm the presence of treponemal antibodies, CMIA-reactive sera were tested by standard Treponema pallidum haemagglutination assay (TPHA)...
  76. Luthra A, Anand A, Hawley K, Ledoyt M, La Vake C, Caimano M, et al. A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326. J Bacteriol. 2015;197:1906-20 pubmed publisher
    We recently demonstrated that TP_0326 is a bona fide rare outer membrane protein (OMP) in Treponema pallidum and that it possesses characteristic BamA bipartite topology...
  77. Huh H, Chung J, Park S, Chae S. Comparison of automated treponemal and nontreponemal test algorithms as first-line syphilis screening assays. Ann Lab Med. 2016;36:23-7 pubmed publisher
    Automated Mediace Treponema pallidum latex agglutination (TPLA) and Mediace rapid plasma reagin (RPR) assays are used by many laboratories for syphilis diagnosis...
  78. Noda A, Grillová L, Lienhard R, Blanco O, Rodríguez I, Šmajs D. Bejel in Cuba: molecular identification of Treponema pallidum subsp. endemicum in patients diagnosed with venereal syphilis. Clin Microbiol Infect. 2018;: pubmed publisher
    Bejel, caused by Treponema pallidum subsp. endemicum (TEN), was until now considered as a non-venereal disease endemic in areas with hot and dry climates...
  79. Neu N, Duchon J, Zachariah P. TORCH infections. Clin Perinatol. 2015;42:77-103, viii pubmed publisher
    TORCH infections classically comprise toxoplasmosis, Treponema pallidum, rubella, cytomegalovirus, herpesvirus, hepatitis viruses, human immunodeficiency virus, and other infections, such as varicella, parvovirus B19, and enteroviruses...
  80. Strieder L, León J, Carvalho Y, Kaminagakura E. Oral syphilis: report of three cases and characterization of the inflammatory cells. Ann Diagn Pathol. 2015;19:76-80 pubmed publisher
    Syphilis is a sexually transmitted infectious disease caused by Treponema pallidum. This study reports 3 cases of syphilis and highlights the importance of identifying oral lesions for its final diagnosis...
  81. STAMM L. Pinta: Latin America's Forgotten Disease?. Am J Trop Med Hyg. 2015;93:901-3 pubmed publisher
    ..Treponema carateum, cannot be distinguished morphologically or serologically from the not-yet-cultivable Treponema pallidum subspecies that cause venereal syphilis, yaws, and bejel...
  82. Shimelis T, Lemma K, Ambachew H, Tadesse E. Syphilis among people with HIV infection in southern Ethiopia: sero-prevalence and risk factors. BMC Infect Dis. 2015;15:189 pubmed publisher
    ..for syphilis using rapid plasma reagin (RPR) test, and those found sero-positive were confirmed using treponema pallidum haemagglutination assay (TPHA). The sero-prevalence of syphilis was found to be 7.3% (95% CI 5.7- 9%)...
  83. Li Z, Feng Z, Liu P, Yan C. Screening for antibodies against Treponema pallidum with chemiluminescent microparticle immunoassay: analysis of discordant serology results and clinical characterization. Ann Clin Biochem. 2016;53:588-92 pubmed publisher
    ..Recent availability of a chemiluminescent microparticle immunoassay for detecting antibodies against Treponema pallidum has led several laboratories in China to adopt chemiluminescent microparticle immunoassay for screening of ..
  84. Zhang J, Xu J, Song W, Pan S, Chu Z, Hu Q, et al. HIV Incidence and Care Linkage among MSM First-Time-Testers in Shenyang, China 2012-2014. AIDS Behav. 2018;22:711-721 pubmed publisher
    ..Syphilis was screened by the rapid plasma reagent test (RPR) and confirmed by Treponema pallidum particle assay (TPPA)...
  85. Pinilla G, Campos L, Durán A, Navarrete J, Muñoz L. Detección de Treponema pallidum subespecie pallidum para el diagnóstico de sífilis congénita mediante reacción en cadena de la polimerasa anidada. Biomedica. 2018;38:128-35 pubmed publisher
    Introducción. La sífilis es una enfermedad producida por Treponema pallidum subespecie pallidum cuya incidencia mundial es de 12 millones de casos por año, aproximadamente; de estos, más de dos millones se presentan en mujeres ..
  86. Lu H, Li K, Gong W, Yan L, Gu X, Chai Z, et al. High frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilis. Emerg Microbes Infect. 2015;4:e10 pubmed publisher
    ..We used polymerase chain reaction technology to detect a 23S rRNA A2058G mutation in Treponema pallidum in 109 specimens from syphilis patients...
  87. Zhang R, Qian J, Wang Z, Yuan Y. [Ocular manifestations of syphilitic uveoretinitis in patients co-infected with human immunodeficiency virus]. Zhonghua Yan Ke Za Zhi. 2015;51:739-45 pubmed
    ..Patients were selected with positive serologic tests, including rapid plasma regain titer (RPR) > 1:8, treponema pallidum particle agglutination assay (TPPA) and human immunodeficiency virus (HIV)...
  88. Dickeson D, Chen S, Sintchenko V. Concordance of four commercial enzyme immunoassay and three immunoblot formats for the detection of Lyme borreliosis antibodies in human serum: the two-tier approach remains. Pathology. 2016;48:251-6 pubmed publisher
    ..some non-specific reactions in sera containing antibodies to Leptospira species, Helicobacter pylori and Treponema pallidum. The use of recombinant antigens in EIA for LB IgG screening significantly improves the predictive values of ..
  89. Crestani S, Leitolis A, Lima L, Krieger M, Foti L. Enhanced target-specific signal detection using an Escherichia coli lysate in multiplex microbead immunoassays with E. coli-derived recombinant antigens. J Immunol Methods. 2016;435:17-26 pubmed publisher
    ..However, for the Treponema pallidum p47 antigen improvement in MFI was only observed for the preparation with the E...
  90. Strouhal M, Oppelt J, Mikalová L, Arora N, Nieselt K, Gonzalez Candelas F, et al. Reanalysis of Chinese Treponema pallidum samples: all Chinese samples cluster with SS14-like group of syphilis-causing treponemes. BMC Res Notes. 2018;11:16 pubmed publisher
    b>Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis...
  91. Saad Roy C, Shuai Z, van den Driessche P. A mathematical model of syphilis transmission in an MSM population. Math Biosci. 2016;277:59-70 pubmed publisher
    Syphilis is caused by the bacterium Treponema pallidum subspecies pallidum, and is a sexually transmitted disease with multiple stages...
  92. Knauf S, Raphael J, Mitjà O, Lejora I, Chuma I, Batamuzi E, et al. Isolation of Treponema DNA from Necrophagous Flies in a Natural Ecosystem. EBioMedicine. 2016;11:85-90 pubmed publisher
    ..Health Organization launched a campaign to eradicate the tropical disease yaws, caused by the bacterium Treponema pallidum subsp...