Treponema denticola

Summary

Alias: Treponema comandonii, Spirochaeta comandonii, Spirochaeta dentium, Spirochaeta microdentium, Spirochaeta orthodonta, Spirochaete denticola, Spirochaete dentium, Spironema dentium, Treponema ambiguum, Spirochaeta ambigua, Treponema denticola (ex Brumpt 1925) Chan et al. 1993, Treponema denticola (ex Flugge 1886) Chan et al. 1993, Treponema dentium, Treponema dentium-stenogyratum, Treponema microdentium, Treponema orthodontum, "Spirillum dentium" (Miller 1889) Sternberg 1892, Spirillum dentium, "Treponema orthodontum" (Hoffmann 1920) Noguchi 1928, "Treponema microdentium" Noguchi 1912, "Treponema dentium-stenogyratum" Pettit 1928, "Treponema dentium" (Miller 1889) Dobell 1912, "Treponema comandonii" (Seguin and Vinzent 1936) Prevot 1940, "Treponema ambiguum" (Seguin and Vinzent 1936) Prevot 1940, "Spironema dentium" (Miller 1889) Gross 1912, "Spirochaete dentium" Miller 1889, "Spirochaete denticola" Flugge 1886, "Spirochaeta orthodonta" Hoffmann 1920, "Spirochaeta microdentium" (Noguchi 1912) Heim 1922, "Spirochaeta dentium" (Miller 1889) Migula 1895, "Spirochaeta comandonii" Seguin and Vinzent 1936, "Spirochaeta ambigua" Seguin and Vinzent 1936

Top Publications

  1. Ran S, Liu B, Gu S, Sun Z, Liang J. Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth. Arch Oral Biol. 2017;78:39-47 pubmed publisher
    ..4%), Tannerella forsythia (19/47, 40.4%), Actinomyces sp. (17/47, 36.17%), Treponema denticola (10/47,21.28%), Actinomyces israelii (9/47,19.15%), Prevotella intermedia (6/47, 12...
  2. Tatikonda A, Sudheep N, Biswas K, Gowtham K, Pujari S, Singh P. Evaluation of Bacteriological Profile in the Apical Root Segment of the Patients with Primary Apical Periodontitis. J Contemp Dent Pract. 2017;18:44-48 pubmed
    ..Streptococcus species, Olsenella uli, Synergistes species, Fusobacterium nucleatum, Parvimonas micra, Treponema denticola, and Filifactor alocis were the specific species detected...
  3. Yun I, Ahn S, Yoon W, Kim C, Lim Y, Kook J, et al. Litsea japonica Leaf Extract Suppresses Proinflammatory Cytokine Production in Periodontal Ligament Fibroblasts Stimulated with Oral Pathogenic Bacteria or Interleukin-1?. Int J Mol Sci. 2018;19: pubmed publisher
    ..with various oral bacteria, including Fusobacterium nucleatum, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia...
  4. Louhelainen A, Aho J, Tuomisto S, Aittoniemi J, Vuento R, Karhunen P, et al. Oral bacterial DNA findings in pericardial fluid. J Oral Microbiol. 2014;6:25835 pubmed publisher
    ..Parvimonas micra) and periodontal disease (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, Fusobacterium nucleatus, and Dialister pneumosintes). Of 22 cases, 14 (63...
  5. Gaetti Jardim E, Pereira M, Vieira E, Schweitzer C, Okamoto A, Ávila Campos M. Occurrence of periodontal pathogens in ethnic groups from a native Brazilian reservation. Arch Oral Biol. 2015;60:959-65 pubmed publisher
    ..forsythia, P. gingivalis, P. gulae, Porphyromonas endodontalis, P. intermedia, and Prevotella nigrescens. Treponema denticola was uncommon...
  6. Lee L, Lee Y, Hsiao S, Lin H. Bacteria in the apical root canals of teeth with apical periodontitis. J Formos Med Assoc. 2017;116:448-456 pubmed publisher
    ..endodontalis was detected in 10; Bacteroides, Dialister invisus or Fusobacterium nucleatum in 9; Treponema denticola or Enterococcus faecalis in 8; Peptostreptococcus or Olsenella uli in 6; and Veillonella in 5 teeth...
  7. Jang J, Song I, Baek K, Choi Y, Ji S. Immunologic characteristics of human gingival fibroblasts in response to oral bacteria. J Periodontal Res. 2017;52:447-457 pubmed publisher
    ..Differential degradation of proteins by the six bacterial species was observed: P. gingivalis and Treponema denticola degraded proteins well, whereas the other species degraded proteins to a relatively lower degree...
  8. de Carvalho Baptista I, Martinho F, Nascimento G, da Rocha Santos C, Prado R, Valera M. Colonization of oropharynx and lower respiratory tract in critical patients: Risk of ventilator-associated pneumonia. Arch Oral Biol. 2018;85:64-69 pubmed publisher
    ..Fusobacterium periodonticum, Gemella morbillorum, Neisseria mucosa, Propionibacterium acnes, Prevotella melaninogenica, Streptococcus oralis, Streptococcus sanguinis, Treponema denticola, Treponema socransckii, and Veillonella parvula.
  9. Corrêa J, Saraiva A, Queiroz Junior C, Madeira M, Duarte P, Teixeira M, et al. Arthritis-induced alveolar bone loss is associated with changes in the composition of oral microbiota. Anaerobe. 2016;39:91-6 pubmed publisher
    ..Prevotella nigrescens and Treponema denticola were detected only in the Y4 group whereas Campylobacter showae, Streptococcus mitis and Streptococcus ..

More Information

Publications109 found, 100 shown here

  1. Azad M, Schwiertz A, Jentsch H. Adjunctive use of essential oils following scaling and root planing -a randomized clinical trial. BMC Complement Altern Med. 2016;16:171 pubmed publisher
    ..1). BOP improved better in the test group after 3 months (p??=??0.065). Numbers of Treponema denticola (p??=??0.044) and Fusobacterium nucleatum (p??=??0...
  2. Swati P, Thomas B, Vahab S, Kapaettu S, Kushtagi P. Simultaneous detection of periodontal pathogens in subgingival plaque and placenta of women with hypertension in pregnancy. Arch Gynecol Obstet. 2012;285:613-9 pubmed publisher
    ..Subgingival plaque and placental biopsy were studied for Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola, Prevotella intermedia and Aggregatibacter actinomycetemcomitans using quantitative polymerase chain ..
  3. Li Z, Yang R, Wang Q, Zhang D, Zhuang S, Yamaguchi Y. Electrophoresis of periodontal pathogens in poly(ethyleneoxide) solutions with uncoated capillary. Anal Biochem. 2015;471:70-2 pubmed publisher
    ..g), Treponema denticola (T.d), and Tannerella forsythia (T.f)...
  4. Borilova Linhartova P, Kastovsky J, Lucanova S, Bartova J, Poskerova H, Vokurka J, et al. Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria. Mediators Inflamm. 2016;2016:2979846 pubmed publisher
    ..05). IL-17A polymorphism increased the number of Tannerella forsythia and Treponema denticola in patients with CP and T1DM + CP, respectively (P < 0.05)...
  5. Usin M, Tabares S, Menso J, de Albera E, Sembaj A. Generalized aggressive periodontitis: microbiological composition and clinical parameters in non-surgical therapy. Acta Odontol Latinoam. 2016;29:255-261 pubmed
    ..encada sextante para identificar mediante técnica de biología molecular: Porphyromonas gingivalis, Treponema denticola, forsythia Tannerella, Prevotella intermedia, y Aggregatibacter actinomycetemcomitans...
  6. Izui S, Sekine S, Maeda K, Kuboniwa M, Takada A, Amano A, et al. Antibacterial Activity of Curcumin Against Periodontopathic Bacteria. J Periodontol. 2016;87:83-90 pubmed publisher
    ..Curcumin inhibited the growth of P. gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Treponema denticola in a dose-dependent manner...
  7. Machado F, Cesar D, Apolônio A, Ribeiro L, Ribeiro R. Longitudinal study on clinical and microbial analysis of periodontal status in pregnancy. Braz Oral Res. 2016;30:e87 pubmed publisher
    ..No significant changes were found for Fusobacterium nucleatum, Treponema denticola, or Tannerella forsythia...
  8. Kataoka N, Vangnai A, Pongtharangkul T, Yakushi T, Matsushita K. Butyrate production under aerobic growth conditions by engineered Escherichia coli. J Biosci Bioeng. 2017;123:562-568 pubmed publisher
    ..phaJ ((R)-specific enoyl-CoA hydratase) from Aeromonas caviae, ter (trans-enoyl-CoA reductase) from Treponema denticola, and endogenous thioesterase(s) of E. coli...
  9. Bale B, Doneen A, Vigerust D. High-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis. Postgrad Med J. 2017;93:215-220 pubmed publisher
    ..actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola or Fusobacterium nucleatum There are three accepted essential elements in the pathogenesis of ..
  10. Cosgarea R, Tristiu R, Dumitru R, Arweiler N, Rednic S, Sirbu C, et al. Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis. Clin Oral Investig. 2018;: pubmed publisher
    ..Counts of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola decreased statistically significantly in CP but not in the RA-CP group...
  11. Kataoka N, Vangnai A, Pongtharangkul T, Tajima T, Yakushi T, Matsushita K, et al. Construction of CoA-dependent 1-butanol synthetic pathway functions under aerobic conditions in Escherichia coli. J Biotechnol. 2015;204:25-32 pubmed publisher
    ..phaJ ((R)-specific enoyl-CoA hydratase) from Aeromonas caviae, ter (trans-enoyl-CoA reductase) from Treponema denticola, bld (butylraldehyde dehydrogenase) from Clostridium saccharoperbutylacetonicum, and inherent alcohol ..
  12. Nakajima T, Okui T, Ito H, Nakajima M, Honda T, Shimada Y, et al. Microbiological and Clinical Effects of Sitafloxacin and Azithromycin in Periodontitis Patients Receiving Supportive Periodontal Therapy. Antimicrob Agents Chemother. 2016;60:1779-87 pubmed publisher
    ..The proportions of red complex bacteria, i.e., Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, which are the representative periodontopathic bacteria, were significantly ..
  13. Chen J, Ni Y, Liu C, Yamaguchi Y, Chen Q, Sekine S, et al. Rapid identification and quantitation for oral bacteria based on short-end capillary electrophoresis. Talanta. 2016;160:425-430 pubmed publisher
    ..g), Treponema denticola (T.d) and Tannerela forsythia (T.f))...
  14. Belstrøm D, Sembler Møller M, Grande M, Kirkby N, Cotton S, Paster B, et al. Microbial profile comparisons of saliva, pooled and site-specific subgingival samples in periodontitis patients. PLoS ONE. 2017;12:e0182992 pubmed publisher
    ..Presence of Porphyromonas gingivalis, Treponema denticola, Prevotella intermedia, Filifactor alocis, Tannerella forsythia and Parvimona micra in site-specific ..
  15. Li Y, Feng X, Xu L, Zhang L, Lu R, Shi D, et al. Oral microbiome in chinese patients with aggressive periodontitis and their family members. J Clin Periodontol. 2015;42:1015-23 pubmed publisher
    ..The relative abundance of P. gingivalis and Red complex pathogens (P. gingivalis, Treponema denticola and Tannerella forsythia) in the subgingival plaque and saliva samples from the same individual were ..
  16. Jensen A, Ladegaard Grønkjær L, Holmstrup P, Vilstrup H, Kilian M. Unique subgingival microbiota associated with periodontitis in cirrhosis patients. Sci Rep. 2018;8:10718 pubmed publisher
    ..Bacteria usually considered periodontal pathogens, like Porhyromonas ginigivalis, Tannerella forsythia, Treponema denticola, generally showed low abundancy...
  17. Grzech Leśniak K, Sculean A, Gaspirc B. Laser reduction of specific microorganisms in the periodontal pocket using Er:YAG and Nd:YAG lasers: a randomized controlled clinical study. Lasers Med Sci. 2018;: pubmed publisher
    ..2%) failed to reduce Treponema denticola, Peptostreptococcus micros, and Capnocytophaga gingivalis...
  18. Ng H, Kin L, Dashper S, Slakeski N, Butler C, Reynolds E. Bacterial interactions in pathogenic subgingival plaque. Microb Pathog. 2016;94:60-9 pubmed publisher
    ..In the oral cavity, interactions between key oral bacterial species, including Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, are essential for the progression of chronic periodontitis. In vivo, P...
  19. Schmalz G, Tsigaras S, Rinke S, Kottmann T, Haak R, Ziebolz D. Detection of five potentially periodontal pathogenic bacteria in peri-implant disease: A comparison of PCR and real-time PCR. Diagn Microbiol Infect Dis. 2016;85:289-294 pubmed publisher
    ..dye SYBR green-system): Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Treponema denticola (Td), Tanerella forsythia (Tf), and Fusobacterium nucleatum (Fn)...
  20. Bernasconi L, Ramenzoni L, Al Majid A, Tini G, Graber S, Schmidlin P, et al. Elevated Matrix Metalloproteinase Levels in Bronchi Infected with Periodontopathogenic Bacteria. PLoS ONE. 2015;10:e0144461 pubmed publisher
    ..In multiple linear regression models the presence of Treponema denticola showed a consistent pattern of positive effects in bronchial fluid (Bonferroni adjusted p-values) on the ..
  21. Raj K, Musalaiah S, Nagasri M, Kumar P, Reddy P, Greeshma M. Evaluation of efficacy of photodynamic therapy as an adjunct to nonsurgical periodontal therapy in treatment of chronic periodontitis patients: A clinico-microbiological study. Indian J Dent Res. 2016;27:483-487 pubmed publisher
    ..Microbiological assessment of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola was done by polymerase chain reaction (PCR) at baseline and 3 months after the therapy...
  22. Okada A, Sogabe K, Takeuchi H, Okamoto M, Nomura Y, Hanada N. Characterization of specimens obtained by different sampling methods for evaluation of periodontal bacteria. J Oral Sci. 2017;59:491-498 pubmed publisher
    ..for quantitative analysis of the counts of three periodontal bacterial species: Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia...
  23. Houston S, Taylor J, Denchev Y, Hof R, Zuerner R, Cameron C. Conservation of the Host-Interacting Proteins Tp0750 and Pallilysin among Treponemes and Restriction of Proteolytic Capacity to Treponema pallidum. Infect Immun. 2015;83:4204-16 pubmed publisher
    ..We also determined the proteolytic potential of the orthologs from the less invasive species Treponema denticola and Treponema phagedenis...
  24. Jervøe Storm P, Jepsen S, Jöhren P, Mericske Stern R, Enkling N. Internal bacterial colonization of implants: association with peri-implant bone loss. Clin Oral Implants Res. 2015;26:957-963 pubmed publisher
    ..actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, and Tannerella forsythia as well as total bacterial counts by real-time PCR...
  25. Kargas K, Tsalikis L, Sakellari D, Menexes G, Konstantinidis A. Pilot study on the clinical and microbiological effect of subgingival glycine powder air polishing using a cannula-like jet. Int J Dent Hyg. 2015;13:161-9 pubmed publisher
    ..analysed using 'checkerboard' DNA-DNA hybridization for Porphyromonas gingivalis, Tannerrella forsythia and Treponema denticola. All groups were homogeneous at baseline for the clinical parameters assessed...
  26. Hincapié J, Castrillón C, Yepes F, Roldán N, Becerra M, Moreno S, et al. Microbiological effects of periodontal therapy plus azithromycin in patients with diabetes: results from a randomized clinical trial. Acta Odontol Latinoam. 2014;27:89-95 pubmed publisher
    ..was to determine the changes in the frequency with which Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola and Aggregatibacter actinomycetemcomitans were detected in patients with diabetes with the use of non-..
  27. Ardila C, Guzmán I. Association of Porphyromonas gingivalis with high levels of stress-induced hormone cortisol in chronic periodontitis patients. J Investig Clin Dent. 2016;7:361-367 pubmed publisher
    ..Porphyromonas gingivalis (P. gingivalis) Tannerella forsythia, Treponema denticola, and Aggregatibacter actinomycetemcomitans were detected by polymerase chain reaction using primers ..
  28. Sparks Stein P, Steffen M, Smith C, Jicha G, Ebersole J, Abner E, et al. Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease. Alzheimers Dement. 2012;8:196-203 pubmed publisher
    ..including Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Campylobacter rectus, Treponema denticola, Fusobacterium nucleatum, Tannerella forsythia, and Prevotella intermedia...
  29. Birsan I. Polymerase chain reaction as a prospect for the early diagnosis and prediction of periodontal diseases in adolescents. Eur Arch Paediatr Dent. 2015;16:9-12 pubmed publisher
    ..i), Tannerella forsythia (T.f) [Bacteroides forsythus], Treponema denticola (T.d), Actinobacillus actinomycetemcomitans (A.a), Porphyromonas gingivalis (P...
  30. Zhuang L, Watt R, Mattheos N, Si M, Lai H, Lang N. Periodontal and peri-implant microbiota in patients with healthy and inflamed periodontal and peri-implant tissues. Clin Oral Implants Res. 2016;27:13-21 pubmed publisher
    ..g.), Treponema denticola (T.d.), Aggregatibacter actinomycetemcomitans (A.a.), Fusobacterium nucleatum (F.n...
  31. Feng X, Zhu L, Xu L, Meng H, Zhang L, Ren X, et al. Distribution of 8 periodontal microorganisms in family members of Chinese patients with aggressive periodontitis. Arch Oral Biol. 2015;60:400-7 pubmed publisher
    ..including Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Campylobacter rectus, Prevotella intermedia, Prevotella nigrescens and Fusobacterium nucleatum were ..
  32. de Araujo Neris M, Cortelli S, Aquino D, de Miranda T, Costa F, Cortelli J. A. actinomycetemcomitans profile and red complex bacterial species of an Afro-Brazilian community: A comparative study. Arch Oral Biol. 2015;60:753-9 pubmed publisher
    ..actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola was carried out by qPCR. Then, A...
  33. Zinicola M, Lima F, Lima S, Machado V, Gomez M, Döpfer D, et al. Altered microbiomes in bovine digital dermatitis lesions, and the gut as a pathogen reservoir. PLoS ONE. 2015;10:e0120504 pubmed publisher
    ..b>Treponema denticola, Treponema maltophilum, Treponema medium, Treponema putidum, Treponema phagedenis and Treponema ..
  34. Sales Peres S, de Moura Grec P, Yamashita J, Torres E, Dionísio T, Leite C, et al. Periodontal status and pathogenic bacteria after gastric bypass: a cohort study. J Clin Periodontol. 2015;42:530-6 pubmed publisher
    ..for quantification of the periodontopathogenic bacteria Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Prevotella intermedia using q-PCR; body mass index (BMI) and for collection of the individual's health-..
  35. Kylmä A, Jouhi L, Listyarifah D, Mohamed H, Mäkitie A, Remes S, et al. Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma. Br J Cancer. 2018;119:89-95 pubmed publisher
    An opportunistic oral pathogen, Treponema denticola (Td), has been linked to orodigestive carcinogenesis, but its role in oropharyngeal squamous cell carcinoma (OPSCC) has remained open...
  36. Sarkar J, MILLER D, Oliver L, Marconi R. The Treponema denticola PAS Domain-Containing Histidine Kinase Hpk2 Is a Heme Binding Sensor of Oxygen Levels. J Bacteriol. 2018;200: pubmed publisher
    ..i>Treponema denticola thrives in periodontal pockets, indicating that it has a unique ability to adapt to changing ..
  37. Fonseca D, Cortelli J, Cortelli S, Miranda Cota L, Machado Costa L, Moreira Castro M, et al. Clinical and Microbiologic Evaluation of Scaling and Root Planing per Quadrant and One-Stage Full-Mouth Disinfection Associated With Azithromycin or Chlorhexidine: A Clinical Randomized Controlled Trial. J Periodontol. 2015;86:1340-51 pubmed publisher
    ..bacterial counts of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Streptococcus oralis were measured with real-time polymerase chain reaction at baseline and 90 and 180 ..
  38. Yanushevich O, Ayvazova R, Shibaeva A, Rebrikov D, Trubnikova E, Kudykina Y, et al. Quantitative PCR studies of Aggregatibacter actinomycetemcomitans and Treponema denticola/Tanerella forsythensis Complex as Etiological Factors of Chronic Periodontitis. Bull Exp Biol Med. 2016;160:495-7 pubmed publisher
    ..actinomycetemcomitans, with T. forsythensis/T. denticola complex, and cases of uncertain genesis. ..
  39. Ata Ali J, Flichy Fernández A, Alegre Domingo T, Ata Ali F, Palacio J, Peñarrocha Diago M. Clinical, microbiological, and immunological aspects of healthy versus peri-implantitis tissue in full arch reconstruction patients: a prospective cross-sectional study. BMC Oral Health. 2015;15:43 pubmed publisher
    ..The periodontopathogenic bacteria Tannerella forsythia, Treponema denticola and Porphyromonas gingivalis were evaluated, together with the total bacterial load (TBL)...
  40. Vieira M, Nascimento A. Interaction of spirochetes with the host fibrinolytic system and potential roles in pathogenesis. Crit Rev Microbiol. 2016;42:573-87 pubmed publisher
    The pathogenic spirochetes Borrelia burgdorferi, B. hermsii, B. recurrentis, Treponema denticola and Leptospira spp. are the etiologic agents of Lyme disease, relapsing fever, periodontitis and leptospirosis, respectively...
  41. Collins J, Arredondo A, Roa A, Valdez Y, León R, Blanc V. Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults. Clin Oral Investig. 2016;20:349-56 pubmed publisher
    ..Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella ..
  42. Torrungruang K, Jitpakdeebordin S, Charatkulangkun O, Gleebbua Y. Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Treponema denticola / Prevotella intermedia Co-Infection Are Associated with Severe Periodontitis in a Thai Population. PLoS ONE. 2015;10:e0136646 pubmed publisher
    ..of Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Treponema denticola (Td), and Prevotella intermedia (Pi) in subgingival plaque were performed using real-time polymerase chain ..
  43. Yáñez Vico R, Iglesias Linares A, Ballesta Mudarra S, Ortiz Ariza E, Solano Reina E, Perea E. Short-term effect of removal of fixed orthodontic appliances on gingival health and subgingival microbiota: a prospective cohort study. Acta Odontol Scand. 2015;73:496-502 pubmed publisher
    ..actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola were performed...
  44. Cortelli S, Costa F, Rodrigues E, Cota L, Cortelli J. Periodontal Therapy Effects on Nitrite Related to Oral Bacteria: A 6-Month Randomized Clinical Trial. J Periodontol. 2015;86:984-94 pubmed publisher
    ..total bacterial, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Streptococcus oralis, and Actinomyces naeslundii levels...
  45. Moreno S, Jaramillo A, Parra B, Botero J, Contreras A. Porphyromonas gingivalis Fim-A genotype distribution among Colombians. Colomb Med (Cali). 2015;46:122-7 pubmed
    ..in subjects from Cali-Colombia, including the co-infection with Aggregatibacter actinomycetemcomitans, Treponema denticola, and Tannerella forsythia...
  46. Ata Ali J, Flichy Fernández A, Alegre Domingo T, Ata Ali F, Peñarrocha Diago M. Impact of heavy smoking on the clinical, microbiological and immunological parameters of patients with dental implants: a prospective cross-sectional study. J Investig Clin Dent. 2016;7:401-409 pubmed publisher
    ..Periodontopathogenic bacteria Tannerella forsythia, Treponema denticola, and Porphyromonas gingivalis were evaluated, together with the total bacterial load...
  47. Hur Y, Choi S, Ogata Y, Stark P, Levi P. Microbiologic Findings in Relation to Risk Assessment for Periodontal Disease: A Cross-Sectional Study. J Periodontol. 2016;87:21-6 pubmed publisher
    ..b>Treponema denticola and Prevotella intermedia (P = 0.01 and P = 0...
  48. Xu X, Steffensen B, Robichaud T, Mikhailova M, Lai V, Montgomery R, et al. Fibronectin-binding protein TDE1579 affects cytotoxicity of Treponema denticola. Anaerobe. 2015;36:39-48 pubmed publisher
    ..fibronectin (FN) binding proteins has been studied in several gram-positive bacteria, the gram-negative Treponema denticola, an anaerobic periodontal pathogen, also has an overlooked fbp gene (tde1579)...
  49. Demmer R, Jacobs D, Singh R, Zuk A, Rosenbaum M, Papapanou P, et al. Periodontal Bacteria and Prediabetes Prevalence in ORIGINS: The Oral Infections, Glucose Intolerance, and Insulin Resistance Study. J Dent Res. 2015;94:201S-11S pubmed publisher
    ..were assessed at baseline, including Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Actinomyces naeslundii...
  50. Li Y, Ruby J, Wu H. Kanamycin Resistance Cassette for Genetic Manipulation of Treponema denticola. Appl Environ Microbiol. 2015;81:4329-38 pubmed publisher
    b>Treponema denticola has been recognized as an important oral pathogen of the "red complex" bacterial consortium that is associated with the pathogenesis of endodontal and periodontal diseases...
  51. Mahendra J, Mahendra L, Nagarajan A, Mathew K. Prevalence of eight putative periodontal pathogens in atherosclerotic plaque of coronary artery disease patients and comparing them with noncardiac subjects: A case-control study. Indian J Dent Res. 2015;26:189-95 pubmed publisher
    ..f), Campylobacter rectus (C.r), Eikenella corrodens (E.c), Porphyromonas gingivalis (P.g), Treponema denticola (T.d), Prevotella nigrescens (P.n) ,Aggregatibacter actinomycetemcomitans (A.a), P...
  52. Nayar G, Gauna A, Chukkapalli S, Velsko I, Kesavalu L, Cha S. Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease. Anaerobe. 2016;38:70-75 pubmed publisher
    ..oral lavage consisting of polymicrobial inocula, namely Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, or sham-infected for 12 weeks (n = 6)...
  53. Carvalho V, Andrade P, Rodrigues M, Hirata M, Hirata R, Pannuti C, et al. Antimicrobial photodynamic effect to treat residual pockets in periodontal patients: a randomized controlled clinical trial. J Clin Periodontol. 2015;42:440-7 pubmed publisher
    ..3, 6 and 12 months to quantify Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia by real-time polimerase chain reaction (PCR)...
  54. Neering S, Adyani Fard S, Klocke A, Rüttermann S, Flemmig T, Beikler T. Periodontitis associated with plasminogen deficiency: a case report. BMC Oral Health. 2015;15:59 pubmed publisher
    ..Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, Prevotella intermedia, Prevotella nigrescens and Eikenella corrodens have been detected by realtime ..
  55. Inagaki S, Kimizuka R, Kokubu E, Saito A, Ishihara K. Treponema denticola invasion into human gingival epithelial cells. Microb Pathog. 2016;94:104-11 pubmed publisher
    ..b>Treponema denticola has been implicated in a number of potentially pathogenic processes, including periodontal tissue ..
  56. Hu Z, Zhang Y, Li Z, Yu Y, Kang W, Han Y, et al. Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation. Oncotarget. 2016;7:66700-66712 pubmed publisher
    ..patients, the frequencies of Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum and Treponema denticola were significantly higher with H. pylori infection than those without H. pylori infection (p < 0.05)...
  57. Lu R, Feng X, Xu L, Meng H. [Clinical and putative periodontal pathogens' features of different sites with probing depth reduction after non-surgical periodontal treatment of patients with aggressive periodontitis]. Beijing Da Xue Xue Bao Yi Xue Ban. 2015;47:13-8 pubmed
    ..concentration of succinic acid, acetic acid, propionic acid and butyric acid, and the prevalence of Treponema denticola were significantly higher in sites with PD reduction more than 2 mm sites compared with PD reduction no ..
  58. Anand A, Ledoyt M, Karanian C, Luthra A, Koszelak Rosenblum M, Malkowski M, et al. Bipartite Topology of Treponema pallidum Repeat Proteins C/D and I: OUTER MEMBRANE INSERTION, TRIMERIZATION, AND PORIN FUNCTION REQUIRE A C-TERMINAL β-BARREL DOMAIN. J Biol Chem. 2015;290:12313-31 pubmed publisher
    ..TprC(N) and TprC(C)) orthologous to regions in the major outer sheath protein (MOSP(N) and MOSP(C)) of Treponema denticola and that TprC(C) is solely responsible for β-barrel formation, trimerization, and porin function by the ..
  59. Godovikova V, Goetting Minesky M, Shin J, Kapila Y, Rickard A, Fenno J. A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405. Appl Environ Microbiol. 2015;81:6496-504 pubmed publisher
    Oral pathogens, including Treponema denticola, initiate the dysregulation of tissue homeostasis that characterizes periodontitis. However, progress of research on the roles of T...
  60. Chukkapalli S, Velsko I, Rivera Kweh M, Zheng D, Lucas A, Kesavalu L. Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE null Mice. PLoS ONE. 2015;10:e0143291 pubmed publisher
    ..with a polybacterial consortium of 4 well-characterized periodontal pathogens, Porphyromonas gingivalis, Treponema denticola, Tannerealla forsythia and Fusobacterium nucleatum, that have been identified in human atherosclerotic ..
  61. Eick S, Nydegger J, Bürgin W, Salvi G, Sculean A, Ramseier C. Microbiological analysis and the outcomes of periodontal treatment with or without adjunctive systemic antibiotics-a retrospective study. Clin Oral Investig. 2018;: pubmed publisher
    ..Using 50%-PD5, presence of all Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola and in particular of T. denticola at T1 was associated with good response to therapy...
  62. Untch M, Schlagenhauf U. Inter- and intra-test agreement of three commercially available molecular diagnostic tests for the identification of periodontal pathogens. Clin Oral Investig. 2015;19:2045-52 pubmed publisher
    ..Carpegen® Perio Diagnostik) regarding the detection of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Aggregatibacter actinomycetemcomitans...
  63. Basic A, Blomqvist S, Carlén A, Dahlén G. Estimation of bacterial hydrogen sulfide production in vitro. J Oral Microbiol. 2015;7:28166 pubmed publisher
    ..High H2S production was seen for Fusobacterium spp., Treponema denticola, and Prevotella tannerae, associated with periodontal disease...
  64. Winning L, Patterson C, Cullen K, Stevenson K, Lundy F, Kee F, et al. The association between subgingival periodontal pathogens and systemic inflammation. J Clin Periodontol. 2015;42:799-806 pubmed publisher
    ..real time PCR to identify the presence of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia. High-sensitivity CRP (mg/l) was measured from fasting blood samples...
  65. Petrukhina N, Zorina O, Shikh E, Shibaeva A, Shevelev A. [Study of mutual dependence of periodontal and colonic microbiome in health and pathology using NSG-sequencing]. Stomatologiia (Mosk). 2016;95:8-13 pubmed publisher
    ..are closely related to Aggregatibacter actinomycetemcomitans; Treponema vencentii is a relative of Treponema denticola; Prevotella baroniae, Prevotella salivae and Prevotella spp...
  66. Chukkapalli S, Rivera Kweh M, Gehlot P, Velsko I, Bhattacharyya I, Calise S, et al. Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice. Arthritis Res Ther. 2016;18:161 pubmed publisher
    ..CIA-prone B10.RIII mice were infected orally with a polybacterial mixture of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia for 24 weeks before induction of CIA...
  67. Eick S, Mathey A, Vollroth K, Kramesberger M, Bürgin W, Sculean A, et al. Persistence of Porphyromonas gingivalis is a negative predictor in patients with moderate to severe periodontitis after nonsurgical periodontal therapy. Clin Oral Investig. 2017;21:665-674 pubmed publisher
    ..001, each compared with baseline). Modeling the impact of Porphyromonas gingivalis, Treponema denticola, and median of MMP-8 on to the response to treatment as continuous variables by GLM showed a significant ..
  68. Mahalakshmi K, Krishnan P, Arumugam S. "Association of periodontopathic anaerobic bacterial co-occurrence to atherosclerosis" - A cross-sectional study. Anaerobe. 2017;44:66-72 pubmed publisher
    ..The samples positive for Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia were screened for virulence genes...
  69. Sender Janeczek A, Zietek M. The Distribution of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola and Aggregatibacter actinomycetemcomitans in Patients with Alcoholic Disease: A Pilot Study. Adv Clin Exp Med. 2016;25:243-8 pubmed publisher
    ..disease, the composition of the main periopathogens: Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola and Aggregatibacter actinomycetemcomitans...
  70. Tallarico M, Canullo L, Caneva M, Ozcan M. Microbial colonization at the implant-abutment interface and its possible influence on periimplantitis: A systematic review and meta-analysis. J Prosthodont Res. 2017;61:233-241 pubmed publisher
    ..For data analysis, the total bacterial count of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, and Fusobacterium nucleatum was calculated and compared to IAI with or without peri-..
  71. Huang Y, Zeng J, Chen G, Xie X, Guo W, Tian W. Periodontitis contributes to adipose tissue inflammation through the NF-<kappa>B, JNK and ERK pathways to promote insulin resistance in a rat model. Microbes Infect. 2016;18:804-812 pubmed publisher
    ..model was induced by ligatures and injection of "red complex", which consisted of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, for two weeks...
  72. Mehlotra R, Hall N, Willie B, Stein C, Weinberg A, Zimmerman P, et al. Associations of Toll-Like Receptor and ?-Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study. PLoS ONE. 2016;11:e0164075 pubmed publisher
    ..analyses for levels of 3 periodontopathogens in subgingival dental plaques (Porphyromonas gingivalis [Pg], Treponema denticola [Td], and Tannerella forsythia [Tf]) and 3 clinical measures of PD (periodontal probing depth [PPD], ..
  73. Choi J, Kim S, Hong S, Lee H. Secretable Small RNAs via Outer Membrane Vesicles in Periodontal Pathogens. J Dent Res. 2017;96:458-466 pubmed publisher
    ..msRNAs in the periodontal pathogens Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Treponema denticola. We examined these msRNAs using a deep sequencing method and characterized dozens of msRNAs through ..
  74. Jakovljević A, Andric M, Knezevic A, Milicic B, Beljic Ivanovic K, Perunović N, et al. Herpesviral-bacterial co-infection in mandibular third molar pericoronitis. Clin Oral Investig. 2017;21:1639-1646 pubmed publisher
    ..Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Parvimonas micra, Treponema denticola, and Tannarella forsythia...
  75. Huo Y, Chan Y, Lacap Bugler D, Mo S, Woo P, Leung W, et al. Multilocus Sequence Analysis of Phylogroup 1 and 2 Oral Treponeme Strains. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..Our data confirmed the species differentiation between Treponema denticola (n = 41) and Treponema putidum (n = 7) strains...
  76. Zorina O, Aimadinova N, Basova A, Rebrikov D. [The relationship of molecular genetic markers with clinical signs and risk factors of periodontitis]. Stomatologiia (Mosk). 2016;95:12-18 pubmed publisher
    ..teeth loss risk with periodontal hypercolonization by Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola. Pathological tooth mobility was associated with hypercolonization by P...
  77. Nagano K, Hasegawa Y, Yoshida Y, Yoshimura F. Comparative analysis of motility and other properties of Treponema denticola strains. Microb Pathog. 2017;102:82-88 pubmed publisher
    The periodontitis-associated pathogen Treponema denticola is a spirochetal bacterium that swims by rotating its cell body like a corkscrew using periplasmic flagella...
  78. Hashim N, Linden G, Winning L, Ibrahim M, Gismalla B, Lundy F, et al. Putative periodontal pathogens in the subgingival plaque of Sudanese subjects with aggressive periodontitis. Arch Oral Biol. 2017;81:97-102 pubmed publisher
    ..of four putative periodontal pathogens: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola and Tannerella forsythia. At the lowest detection threshold (>101 cells), P...
  79. Tanaka Kumazawa K, Kikuchi Y, Sano Kokubun Y, Shintani S, Yakushiji M, Kuramitsu H, et al. Characterization of a potential ABC-type bacteriocin exporter protein from Treponema denticola. BMC Oral Health. 2016;17:18 pubmed publisher
    b>Treponema denticola is strongly associated with the development of periodontal disease. Both synergistic and antagonistic effects are observed among bacterial species in the process of biofilm formation...
  80. Oztürk V, Belibasakis G, Emingil G, Bostanci N. Impact of aging on TREM-1 responses in the periodontium: a cross-sectional study in an elderly population. BMC Infect Dis. 2016;16:429 pubmed publisher
    ..The subgingival plaque total bacteria, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, and Prevotella intermedia levels were determined by quantitative real-time ..
  81. Jones M, Vanyo S, Visser M. The C-terminal region of the major outer sheath protein of Treponema denticola inhibits neutrophil chemotaxis. Mol Oral Microbiol. 2017;32:375-389 pubmed publisher
    b>Treponema denticola is an oral spirochete strongly associated with severe periodontal disease...
  82. Chukkapalli S, Velsko I, Rivera Kweh M, Larjava H, Lucas A, Kesavalu L. Global TLR2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection. Mol Oral Microbiol. 2017;32:211-225 pubmed publisher
    ..and TLR4-/- mice to polymicrobial infection with periodontal pathogens Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Fusobacterium nucleatum...
  83. Guarnieri R, Rappelli G, Piemontese M, Procaccini M, Quaranta A. A Double-Blind Randomized Trial Comparing Implants with Laser-Microtextured and Machined Collar Surfaces: Microbiologic and Clinical Results. Int J Oral Maxillofac Implants. 2016;31:1117-25 pubmed publisher
    ..pathogens, namely, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, and Tannerella forsythensis, was assessed using real-time polymerized chain reaction (RT-PCR)...
  84. Jun H, Jung Y, Choi B. Treponema denticola, Porphyromonas gingivalis, and Tannerella forsythia induce cell death and release of endogenous danger signals. Arch Oral Biol. 2017;73:72-78 pubmed publisher
    ..The macrophages were treated with Treponema denticola, Porphyromonas gingivalis, and Tannerella forsythia...
  85. Ziebolz D, Schmalz G, Gollasch D, Eickholz P, Rinke S. Microbiological and aMMP-8 findings depending on peri-implant disease in patients undergoing supportive implant therapy. Diagn Microbiol Infect Dis. 2017;88:47-52 pubmed publisher
    ..Only Treponema denticola (Td) and Prevotella intermedia (Pi) showed significantly higher prevalence in P (healthy implants [HI]: Td=..
  86. Brzezińska Błaszczyk E, Pawłowska E, Płoszaj T, Witas H, Godzik U, Agier J. Presence of archaea and selected bacteria in infected root canal systems. Can J Microbiol. 2018;64:317-326 pubmed publisher
    ..of selected bacteria species (Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Synergistes sp.) in necrotic samples was evaluated as well...
  87. Puig Silla M, Montiel Company J, Dasí Fernández F, Almerich Silla J. Prevalence of periodontal pathogens as predictor of the evolution of periodontal status. Odontology. 2017;105:467-476 pubmed publisher
    ..gingivalis, its fimA genotypes, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Treponema denticola and the evolution of periodontal health...
  88. Chukkapalli S, Easwaran M, Rivera Kweh M, Velsko I, Ambadapadi S, Dai J, et al. Sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in LDLRnull mice. Pathog Dis. 2017;75: pubmed publisher
    ..nucleatum for the first 12 weeks followed by late bacterial colonizers (Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia) for the remaining 12 weeks mimicking the human oral microbiota ecological ..
  89. Marconi R. Gene Regulation, Two Component Regulatory Systems, and Adaptive Responses in Treponema Denticola. Curr Top Microbiol Immunol. 2018;415:39-62 pubmed publisher
    ..The purpose of this chapter is to review the current understanding of the molecular basis of these essential adaptive responses, with a focus on the role of two component regulatory systems with global regulatory potential. ..
  90. Jun H, Jung Y, Ji S, An S, Choi B. Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts. Cell Death Differ. 2018;25:380-391 pubmed publisher
    ..In this study, we demonstrate that Td92, a surface protein of the periodontal pathogen Treponema denticola and a homolog of the Treponema pallidum surface protein Tp92, activates caspase-4 and induces pyroptosis in ..
  91. MILLER D, Oliver L, Tegels B, Reed L, O Bier N, Kurniyati K, et al. The Treponema denticola FhbB Protein Is a Dominant Early Antigen That Elicits FhbB Variant-Specific Antibodies That Block Factor H Binding and Cleavage by Dentilisin. Infect Immun. 2016;84:2051-2058 pubmed publisher
    The Treponema denticola FhbB protein contributes to immune evasion by binding factor H (FH). Cleavage of FH by the T...
  92. Okamoto Shibayama K, Sekino J, Yoshikawa K, Saito A, Ishihara K. Antimicrobial susceptibility profiles of oral Treponema species. Anaerobe. 2017;48:242-248 pubmed publisher
    ..The aim of this study was to assess the susceptibility of Treponema denticola strains, Treponema socranskii, and Treponema vincentii to eleven antimicrobial agents...