Leptospira

Summary

Alias: Leptospira Noguchi 1917 (Approved Lists 1980) emend. Faine and Stallman 1982, Ancona, Canela, Jequitaia

Top Publications

  1. Mitchison M, Bulach D, Vinh T, Rajakumar K, Faine S, Adler B. Identification and characterization of the dTDP-rhamnose biosynthesis and transfer genes of the lipopolysaccharide-related rfb locus in Leptospira interrogans serovar Copenhageni. J Bacteriol. 1997;179:1262-7 pubmed
    ..while reverse transcriptase-mediated PCR analysis indicated that the rfbCDBA gene cluster was expressed in Leptospira. Moreover, it could restore normal LPS phenotype to a defined rfbB::Tn5 mutant of S...
  2. Liu J, Ochieng C, Wiersma S, Ströher U, Towner J, Whitmer S, et al. Development of a TaqMan Array Card for Acute-Febrile-Illness Outbreak Investigation and Surveillance of Emerging Pathogens, Including Ebola Virus. J Clin Microbiol. 2016;54:49-58 pubmed publisher
    ..Brucella spp., Coxiella burnetii, Leptospira spp., Rickettsia spp...
  3. El Tras W, Bruce M, Holt H, Eltholth M, Merien F. Update on the status of leptospirosis in New Zealand. Acta Trop. 2018;188:161-167 pubmed publisher
    ..During this six-year period, exotic serovars of Leptospira interrogans sv Australis and Leptospira kirschneri sv Grippotyphosa were identified in patients who had ..
  4. Anu P, Madanan M, Nair A, Nair G, Nair G, Sudhakaran P, et al. Heterologous Expression, Purification and Characterization of an Oligopeptidase A from the Pathogen Leptospira interrogans. Mol Biotechnol. 2018;60:302-309 pubmed publisher
    ..b>Leptospira is a zoonotic pathogen and causes leptospirosis in mammals...
  5. Kumarihamy K, Ralapanawa D, Jayalath W. Co-existent facial palsy and myocarditis in a 50-year old farmer diagnosed with probable leptospirosis: a case report. BMC Res Notes. 2015;8:26 pubmed publisher
    Leptospirosis is a worldwide zoonotic disease caused by spirochetes belonging to the genus Leptospira. This is a case report on a patient with probable leptospirosis, who developed lower motor neuron facial nerve palsy during the recovery ..
  6. Gonçalves de Albuquerque C, Burth P, Silva A, de Moraes I, Oliveira F, Santelli R, et al. Murine lung injury caused by Leptospira interrogans glycolipoprotein, a specific Na/K-ATPase inhibitor. Respir Res. 2014;15:93 pubmed publisher
    ..We showed p38 activation by GLP-induced lung injury, which was may be linked to Na/K-ATPase inhibition. Lung inflammation induced by GLP was not dependent on TLR4 activation. ..
  7. Tavernier P, Sys S, De Clercq K, De Leeuw I, Caij A, De Baere M, et al. Serologic screening for 13 infectious agents in roe deer (Capreolus capreolus) in Flanders. Infect Ecol Epidemiol. 2015;5:29862 pubmed publisher
    ..8%), and Mycobacterium avium subsp paratuberculosis (4.1%). The lowest prevalences were found for Leptospira (1.7%), bovine viral diarrhoea virus 1 (1.3%), and Coxiella burnetii (1.2%)...
  8. Cleveland C, Denicola A, Dubey J, Hill D, Berghaus R, Yabsley M. Survey for selected pathogens in wild pigs (Sus scrofa) from Guam, Marianna Islands, USA. Vet Microbiol. 2017;205:22-25 pubmed publisher
    ..Exposure to porcine parvovirus, transmissible gastroenteritis, and Leptospira interrogans has been documented in domestic swine but data from wild pigs are lacking...
  9. Sullivan J, Nair N, Potula H, Gomes Solecki M. Eyedrop Inoculation Causes Sublethal Leptospirosis in Mice. Infect Immun. 2017;85: pubmed publisher
    ..We analyzed the outcome of infection of C3H/HeJ mice with Leptospira interrogans serovar Copenhageni using an enzootic mode of transmission, the conjunctival route...

More Information

Publications355 found, 100 shown here

  1. Firth C, Bhat M, Firth M, Williams S, Frye M, Simmonds P, et al. Detection of zoonotic pathogens and characterization of novel viruses carried by commensal Rattus norvegicus in New York City. MBio. 2014;5:e01933-14 pubmed publisher
    ..Streptobacillus moniliformis, Leptospira interrogans, and Seoul hantavirus...
  2. Murray G. The molecular basis of leptospiral pathogenesis. Curr Top Microbiol Immunol. 2015;387:139-85 pubmed publisher
    ..Recent developments in the application of genetic tools in the study of Leptospira have advanced our understanding by allowing the assessment of mutants in animal models...
  3. Gofton A, Oskam C, Lo N, Beninati T, Wei H, McCarl V, et al. Inhibition of the endosymbiont "Candidatus Midichloria mitochondrii" during 16S rRNA gene profiling reveals potential pathogens in Ixodes ticks from Australia. Parasit Vectors. 2015;8:345 pubmed publisher
    ..Bartonella henselae, novel "Candidatus Neoehrlichia" spp., Clostridium histolyticum, Rickettsia spp., and Leptospira inadai...
  4. Minakshi R, Padhan K, Rehman S, Hassan M, Ahmad F. The SARS Coronavirus 3a protein binds calcium in its cytoplasmic domain. Virus Res. 2014;191:180-3 pubmed publisher
    ..orf3a aligned to one calcium pump present in Plasmodium falciparum and the enzyme glutamine synthetase found in Leptospira interrogans...
  5. Ardigò P, D incau M, Pongolini S. Abortion in cattle due to infection with Staphylococcus lugdunensis. J Vet Diagn Invest. 2014;26:818-20 pubmed publisher
    ..caninum, C. burnetii, Chlamydophila spp., Schmallemberg virus, and Leptospira interrogans. All PCR assays were negative...
  6. Goswami R, Goswami R, Basu A, Tripathi S, Chakrabarti S, Chattopadhyay I. Predictors of mortality in leptospirosis: an observational study from two hospitals in Kolkata, eastern India. Trans R Soc Trop Med Hyg. 2014;108:791-6 pubmed publisher
    ..biochemical, demographic and treatment related data (time between onset of symptoms and commencement of leptospira specific antibiotics) of 101 leptospirosis patients were reviewed...
  7. Figueredo J, Siqueira G, de Souza G, Heinemann M, Vasconcellos S, Chapola E, et al. Characterization of two new putative adhesins of Leptospira interrogans. Microbiology. 2017;163:37-51 pubmed publisher
    ..of two novel proteins encoded by the genes LIC11122 and LIC12287, identified in the genome sequences of Leptospira interrogans, annotated, respectively, as a putative sigma factor and a hypothetical protein...
  8. Kumar K, Lall C, Raj R, Vedhagiri K, Vijayachari P. Coexistence and survival of pathogenic leptospires by formation of biofilm with Azospirillum. FEMS Microbiol Ecol. 2015;91: pubmed publisher
    Pathogenic Leptospira spp. represent one cause of leptospirosis worldwide and have long been regarded as solitary organisms in soil and aquatic environments...
  9. Miraglia F, Moreno L, Morais Z, Langoni H, Shimabukuro F, Dellagostin O, et al. Characterization of Leptospira interrogans serovar Pomona isolated from swine in Brazil. J Infect Dev Ctries. 2015;9:1054-61 pubmed publisher
    b>Leptospira interrogans swine infection is a cause of serious economic loss and a potential human health hazard. In Brazil, the most common serovars associated with swine infections are Pomona, Icterohaemorrhagie and Tarassovi...
  10. Headley S, Voltarelli D, de Oliveira V, Bronkhorst D, Alfieri A, Filho L, et al. Association of Histophilus somni with spontaneous abortions in dairy cattle herds from Brazil. Trop Anim Health Prod. 2015;47:403-13 pubmed publisher
    ..bovine viral diarrhea virus (BVDV), bovine herpesvirus 1 (BoHV-1), Listeria monocytogenes, Neospora caninum, Leptospira spp., Brucella abortus, and Histophilus somni...
  11. Karrasch M, Herfurth K, Kläver M, Miethke J, Mayer Scholl A, Luge E, et al. Severe leptospirosis complicated by Epstein-Barr Virus reactivation. Infection. 2015;43:763-9 pubmed publisher
    Weil's disease is a severe, potentially fatal illness following Leptospira interrogans infection...
  12. Vieira M, Nascimento A. Interaction of spirochetes with the host fibrinolytic system and potential roles in pathogenesis. Crit Rev Microbiol. 2016;42:573-87 pubmed publisher
    The pathogenic spirochetes Borrelia burgdorferi, B. hermsii, B. recurrentis, Treponema denticola and Leptospira spp. are the etiologic agents of Lyme disease, relapsing fever, periodontitis and leptospirosis, respectively...
  13. Kuchuloria T, Imnadze P, Mamuchishvili N, Chokheli M, Tsertsvadze T, Endeladze M, et al. Hospital-Based Surveillance for Infectious Etiologies Among Patients with Acute Febrile Illness in Georgia, 2008-2011. Am J Trop Med Hyg. 2016;94:236-42 pubmed publisher
    ..Blood culture and serologic testing were conducted for Leptospira spp., Brucella spp...
  14. Schons Fonseca L, da Silva J, Milanez J, Domingos R, Smith J, Nakaya H, et al. Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans. Nucleic Acids Res. 2016;44:1179-91 pubmed publisher
    We determined the effects of DNA damage caused by ultraviolet radiation on gene expression in Leptospira interrogans using DNA microarrays...
  15. Zhang W, Lu X, Wang W, Ding Z, Fu Y, Zhou X, et al. Inhibitory Effects of Emodin, Thymol, and Astragalin on Leptospira interrogans-Induced Inflammatory Response in the Uterine and Endometrium Epithelial Cells of Mice. Inflammation. 2017;40:666-675 pubmed publisher
    ..In an effort to reduce uterine inflammatory responses induced by Leptospira, we evaluated the anti-inflammation effects of emodin, thymol, and astragalin in a mouse model...
  16. Leibler J, Zakhour C, Gadhoke P, Gaeta J. Zoonotic and Vector-Borne Infections Among Urban Homeless and Marginalized People in the United States and Europe, 1990-2014. Vector Borne Zoonotic Dis. 2016;16:435-44 pubmed publisher
    ..recurrentis, lymphocytic choriomeningitis virus, Wohlfartiimonas chitiniclastica, Seoul hantavirus (SEOV), and Leptospira species was also identified in published studies, with SEOV associated with chronic renal disease later in life...
  17. Wang W, Gao X, Guo M, Zhang W, Song X, Wang T, et al. Leptospira interrogans induces uterine inflammatory responses and abnormal expression of extracellular matrix proteins in dogs. Microb Pathog. 2014;75:1-6 pubmed publisher
    b>Leptospira interrogans (L. interrogans), a worldwide zoonosis, infect humans and animals...
  18. Pereira P, Fernandes L, de Souza G, Vasconcellos S, Heinemann M, Romero E, et al. Multifunctional and Redundant Roles of Leptospira interrogans Proteins in Bacterial-Adhesion and fibrin clotting inhibition. Int J Med Microbiol. 2017;307:297-310 pubmed publisher
    ..The data of this study extend the spectrum of surface-exposed proteins of L. interrogans and indicate a possible role of the originally annotated hypothetical proteins in infection processes. ..
  19. Wuthiekanun V, Amornchai P, Langla S, White N, Day N, Limmathurotsakul D, et al. Antimicrobial Disk Susceptibility Testing of Leptospira spp. Using Leptospira Vanaporn Wuthiekanun (LVW) Agar. Am J Trop Med Hyg. 2015;93:241-3 pubmed publisher
    b>Leptospira Vanaporn Wuthiekanun (LVW) agar was used to develop a disk diffusion assay for Leptospira spp...
  20. Devlin A, Halvorsen P, Miller J, Laster S. Il-10 deficient mice express IFN-? mRNA and clear Leptospira interrogans from their kidneys more rapidly than normal C57BL/6 mice. Immunobiology. 2017;222:768-777 pubmed publisher
    b>Leptospira interrogans (L. interrogans), the causative agent of leptospirosis, is a widespread zoonotic spirochete that lives a dual lifestyle. L...
  21. Siqueira G, Teixeira A, Fernandes L, de Souza G, Kirchgatter K, Romero E, et al. The recombinant LIC10508 is a plasma fibronectin, plasminogen, fibrinogen and C4BP-binding protein of Leptospira interrogans. Pathog Dis. 2016;74: pubmed publisher
    Leptospirosis is a zoonosis caused by pathogenic Leptospira spp. In this study, we report that the recombinant proteins LIC10507, LIC10508 and LIC10509 are recognized by confirmed leptospirosis serum samples at both phases of the disease...
  22. Krajewska J, Arent Z, Zolkiewski M, Kedzierska Mieszkowska S. Isolation and Identification of Putative Protein Substrates of the AAA+ Molecular Chaperone ClpB from the Pathogenic Spirochaete Leptospira interrogans. Int J Mol Sci. 2018;19: pubmed publisher
    ..publications also indicate that ClpB supports the virulence of bacteria, including a pathogenic spirochaete Leptospira interrogans responsible for leptospirosis in both animals and humans...
  23. Sasoni N, Iglesias A, Guerrero S, Arias D. Functional thioredoxin reductase from pathogenic and free-living Leptospira spp. Free Radic Biol Med. 2016;97:1-13 pubmed publisher
    ..The metabolic pathways for redox homeostasis in pathogenic (Leptospira interrogans) and free-living (Leptospira biflexa) leptospires species were not functionally characterized...
  24. Saito M, Nikaido Y, Matsumoto M, Ogawa M, Villanueva S. [The Current Status of Diagnostic Tools for Leptospirosis]. Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi. 2017;27:65-72 pubmed
    Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira spp...
  25. Vijayachari P, Vedhagiri K, Mallilankaraman K, Mathur P, Sardesai N, Weiner D, et al. Immunogenicity of a novel enhanced consensus DNA vaccine encoding the leptospiral protein LipL45. Hum Vaccin Immunother. 2015;11:1945-53 pubmed publisher
    Leptospirosis is a bacterial zoonotic disease caused by an infection with a spirochete belonging to the genus Leptospira. In animals, leptospirosis displays a wide range of pathologies, including fever, abortion, icterus, and uveitis...
  26. Kutsuna S, Kato Y, Koizumi N, Yamamoto K, Fujiya Y, Mawatari M, et al. Travel-related leptospirosis in Japan: a report on a series of five imported cases diagnosed at the National Center for Global Health and Medicine. J Infect Chemother. 2015;21:218-23 pubmed publisher
    ..b>Leptospira interrogans was isolated from one patient's blood sample...
  27. Larson C, Dennis M, Nair R, Llanes A, Peda A, Welcome S, et al. Isolation and characterization of Leptospira interrogans serovar Copenhageni from a dog from Saint Kitts. JMM Case Rep. 2017;4:e005120 pubmed publisher
    ..PCR testing and culture of blood was positive for Leptospira sp...
  28. Herzig C, Mailloux V, Baldwin C. Spectratype analysis of the T cell receptor δ CDR3 region of bovine γδ T cells responding to leptospira. Immunogenetics. 2015;67:95-109 pubmed publisher
    ..a restricted set of WC1 molecules respond immediately by proliferation and interferon-γ production to leptospira following vaccination, preceding the response by CD4 T cells...
  29. O Doherty E, Sayers R, O Grady L, Shalloo L. Effect of exposure to Neospora caninum, Salmonella, and Leptospira interrogans serovar Hardjo on the economic performance of Irish dairy herds. J Dairy Sci. 2015;98:2789-800 pubmed publisher
    The objective of the current study was to quantify the effects of exposure to Salmonella, Neospora caninum, and Leptospira interrogans serovar Hardjo (L...
  30. Hamond C, Martins G, Bremont S, Medeiros M, Bourhy P, Lilenbaum W. Molecular Characterization and Serology of Leptospira kirschneri (Serogroup Grippotyphosa) Isolated from Urine of a Mare Post-Abortion in Brazil. Zoonoses Public Health. 2016;63:191-5 pubmed publisher
    A strain of Leptospira kirschneri (serogroup Grippotyphosa) was cultured from urine of a mare post-abortion in Brazil and characterized by serogrouping, multiple-locus variable-number tandem repeat analysis, PGFE, and sequencing of genes ..
  31. Gonzalez Astudillo V, Bustamante Rengifo J, Bonilla Ã, Lehmicke A, Castillo A, Astudillo Hernández M. Synanthropic Cockroaches (Blattidae: Periplaneta spp.) Harbor Pathogenic Leptospira in Colombia. J Med Entomol. 2016;53:177-82 pubmed publisher
    ..Leptospirosis cases in Colombia are typically linked to peridomestic rodents; however, empirical data suggest that Leptospira-infected patients with no apparent exposure to these reservoirs are common. Cockroaches (Periplaneta spp...
  32. Fratini F, Turchi B, Ferrone M, Galiero A, Nuvoloni R, Torracca B, et al. Is Leptospira able to survive in raw milk? Study on the inactivation at different storage times and temperatures. Folia Microbiol (Praha). 2016;61:413-6 pubmed publisher
    ..some pathogen microorganisms is set by the regional regulation DGR 381/2007, for other microorganisms, such as Leptospira, no recommendations are provided...
  33. Miotto B, Moreno L, Guilloux A, Sousa G, Loureiro A, Moreno A, et al. Molecular and serological characterization of the first Leptospira santarosai strain isolated from a dog. Acta Trop. 2016;162:1-4 pubmed publisher
    Leptospirosis is a zoonotic disease of global importance caused by pathogenic Leptospira species...
  34. Lall C, Vinod Kumar K, Raj R, Vedhagiri K, Sunish I, Vijayachari P. Correlation Between Physicochemical Properties of Soil and Presence of Leptospira. Ecohealth. 2018;: pubmed publisher
    ..The present study was designed to understand the correlation between various soil nutrients and presence of Leptospira in soil samples of different regions of Andaman and Nicobar Islands...
  35. Limmathurotsakul D, Turner E, Wuthiekanun V, Thaipadungpanit J, Suputtamongkol Y, Chierakul W, et al. Fool's gold: Why imperfect reference tests are undermining the evaluation of novel diagnostics: a reevaluation of 5 diagnostic tests for leptospirosis. Clin Infect Dis. 2012;55:322-31 pubmed publisher
    ..tests were negative for leptospirosis on the basis of our diagnostic gold standard, which involves isolation of Leptospira species from blood culture and/or a positive result of a microscopic agglutination test (MAT)...
  36. Picardeau M. Genomics, proteomics, and genetics of leptospira. Curr Top Microbiol Immunol. 2015;387:43-63 pubmed publisher
    ..to construct defined mutants, have allowed the study of virulence factors and more generally the biology in Leptospira. However, pathogenic leptospires remain much less easily transformable than the saprophyte L...
  37. Cerritelli F, Ginevri L, Messi G, Caprari E, Di Vincenzo M, Renzetti C, et al. Clinical effectiveness of osteopathic treatment in chronic migraine: 3-Armed randomized controlled trial. Complement Ther Med. 2015;23:149-56 pubmed publisher
    ..3-Armed randomized controlled trial setting: all patients admitted in the Department of Neurology of Ancona's United Hospitals, Italy, with a diagnosis of migraine and without chronic illness, were considered eligible for ..
  38. Breda L, Hsieh C, Castiblanco Valencia M, da Silva L, Barbosa A, Blom A, et al. Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans. PLoS Negl Trop Dis. 2015;9:e0004192 pubmed publisher
    ..Leptospirosis is a worldwide zoonosis caused by spirochetes from the genus Leptospira. Pathogenic leptospires are able to escape from complement activation by binding to host complement inhibitors ..
  39. Krajewska J, Arent Z, Więckowski D, Zolkiewski M, Kedzierska Mieszkowska S. Immunoreactivity of the AAA+ chaperone ClpB from Leptospira interrogans with sera from Leptospira-infected animals. BMC Microbiol. 2016;16:151 pubmed publisher
    b>Leptospira interrogans is a spirochaete responsible for leptospirosis in mammals. The molecular mechanisms of the Leptospira virulence remain mostly unknown. Recently, it has been demonstrated that L...
  40. Vitale M, Agnello S, Chetta M, Amato B, Vitale G, Bella C, et al. Human leptospirosis cases in Palermo Italy. The role of rodents and climate. J Infect Public Health. 2018;11:209-214 pubmed publisher
    ..Here, we report a molecular survey for pathogenic Leptospira spp. in rodents and two symptomatic human cases of leptospirosis in the city of Palermo, Italy...
  41. Chusri S, McNeil E, Hortiwakul T, Charernmak B, Sritrairatchai S, Santimaleeworagun W, et al. Single dosage of doxycycline for prophylaxis against leptospiral infection and leptospirosis during urban flooding in southern Thailand: a non-randomized controlled trial. J Infect Chemother. 2014;20:709-15 pubmed publisher
    ..Of 641 participants, 600 received doxycycline while 41 did not. Twenty two participants were infected with Leptospira and six developed leptospirosis...
  42. da Silva L, Miragaia L, Breda L, Abe C, Schmidt M, Moro A, et al. Pathogenic Leptospira species acquire factor H and vitronectin via the surface protein LcpA. Infect Immun. 2015;83:888-97 pubmed publisher
    Upon infection, pathogenic Leptospira species bind several complement regulators in order to overcome host innate immunity...
  43. Mayer F, Dos Reis E, Bezerra A, Cerva C, Rosa J, Cibulski S, et al. Pathogenic Leptospira spp. in bats: Molecular investigation in Southern Brazil. Comp Immunol Microbiol Infect Dis. 2017;52:14-18 pubmed publisher
    The present study aimed to investigate the frequency of pathogenic Leptospira spp. in Brazilian bats and to determine possible risk factors associated to it. Ninety two bats of 12 species were evaluated...
  44. Raffray L, Giry C, Thirapathi Y, Reboux A, Jaffar Bandjee M, Gasque P. Increased levels of soluble forms of E-selectin and ICAM-1 adhesion molecules during human leptospirosis. PLoS ONE. 2017;12:e0180474 pubmed publisher
    Leptospirosis is a multisystemic zoonotic disease with infiltration of visceral organs by Leptospira. The capacity of the vascular endothelium to grant immune cell recruitment and activation in target organs during the disease course ..
  45. Gyimesi Z, Burns R, Erol E, Bolin S. ACUTE CLINICAL LEPTOSPIROSIS (GRIPPOTYPHOSA SEROVAR) IN AN ADULT DROMEDARY CAMEL (CAMELUS DROMEDARIUS). J Zoo Wildl Med. 2015;46:605-8 pubmed publisher
    ..and further workup revealed a neutrophilia, hyperfibrinogenemia, renal azotemia, and a rapid onset of a high Leptospira antibody titer during the acute clinical period (Grippotyphosa serovar)...
  46. Weis S, Hartmann K. [Leptospira infections in cats]. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2017;45:103-108 pubmed publisher
    ..However, clinical leptospirosis is rare in cats. Nevertheless, infected cats can shed the pathogen through urine and thus, cats could play an important role in the epidemiology of leptospires. ..
  47. Pereira M. ["New plants that scholars do not know:" scientific exploration of nature in Portuguese East Asia, 1768-1808]. Hist Cienc Saude Manguinhos. 2017;24:665-685 pubmed publisher
    ..de aclimatar no Brasil espécies orientais de interesse econômico, como a pimenta-da-índia, a noz-moscada, a canela, o cravo, a teca e o sândalo, propósito que não foi imediatamente bem-sucedido...
  48. Koizumi N, Muto M, Izumiya H, Suzuki M, Ohnishi M. Multiple-locus variable-number tandem repeat analysis and clinical characterization of Leptospira interrogans canine isolates. J Med Microbiol. 2015;64:288-94 pubmed publisher
    Canine leptospirosis occurs worldwide; however, information on the relationship between Leptospira serotypes/genotypes and virulence in dogs remains limited...
  49. Fink J, Moore G, Landau R, Vemulapalli R. Evaluation of three 5' exonuclease-based real-time polymerase chain reaction assays for detection of pathogenic Leptospira species in canine urine. J Vet Diagn Invest. 2015;27:159-66 pubmed publisher
    Leptospirosis is caused by several pathogenic Leptospira species, and is an important infectious disease of dogs. Early detection of infection is crucial for an effective antibiotic treatment of the disease...
  50. Sahagún Ruiz A, Breda L, Valencia M, Elias W, Munthe Fog L, Garred P, et al. Studies of the binding of ficolin-2 and ficolin-3 from the complement lectin pathway to Leptospira biflexa, Pasteurella pneumotropica and Diarrheagenic Escherichia coli. Immunobiology. 2015;220:1177-85 pubmed publisher
    ..We show for the first time that human ficolin-2 recognizes the nonpathogenic spirochete Leptospira biflexa serovar Patoc, but not the pathogenic Leptospira interrogans serovar Kennewicki strain Fromm...
  51. Jacobs A, Harks F, Hoeijmakers M, Collell M, Segers R. Safety and efficacy of a new octavalent combined Erysipelas, Parvo and Leptospira vaccine in gilts against Leptospira interrogans serovar Pomona associated disease and foetal death. Vaccine. 2015;33:3963-9 pubmed publisher
    ..of a new octavalent combination vaccine containing inactivated Erysipelothrix rhusiopathiae, Parvovirus, and Leptospira interrogans (sensu lato) serogroups Canicola, Icterohaemorrhagiae, Australis (Bratislava), Grippotyphosa, Pomona ..
  52. Volz M, Moos V, Allers K, Luge E, Mayer Scholl A, Nöckler K, et al. Specific CD4+ T-Cell Reactivity and Cytokine Release in Different Clinical Presentations of Leptospirosis. Clin Vaccine Immunol. 2015;22:1276-84 pubmed publisher
    ..severities (patients with mild and severe symptoms) and in control subjects (with and without proven exposure to Leptospira). Whole-blood specimens were stimulated with Leptospira antigens in vitro...
  53. Fouts D, Matthias M, Adhikarla H, Adler B, Amorim Santos L, Berg D, et al. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. PLoS Negl Trop Dis. 2016;10:e0004403 pubmed publisher
    Leptospirosis, caused by spirochetes of the genus Leptospira, is a globally widespread, neglected and emerging zoonotic disease...
  54. Barchiesi F, Montalti R, Castelli P, Nicolini D, Staffolani S, Mocchegiani F, et al. Carbapenem-Resistant Klebsiella pneumoniae influences the outcome of early infections in liver transplant recipients. BMC Infect Dis. 2016;16:538 pubmed
    ..of early bacterial and fungal infections in a cohort of patients who underwent LT at the University Hospital of Ancona over a nine year period. All consecutive patients who underwent LT in our center were considered...
  55. Salazar N, Souza M, Biasioli A, Silva L, Barbosa A. The multifaceted roles of Leptospira enolase. Res Microbiol. 2017;168:157-164 pubmed publisher
    A previous study had demonstrated that Leptospira enolase is secreted extracellularly by a yet unknown mechanism and reassociates with the bacterial membrane. Surface-anchored leptospiral enolase displays plasminogen binding activity...
  56. Campos A, Miranda D, Rodrigues H, da Silva Carneiro Lustosa M, Martins G, Mineiro A, et al. Seroprevalence and risk factors for leptospirosis in cattle, sheep, and goats at consorted rearing from the State of Piauí, northeastern Brazil. Trop Anim Health Prod. 2017;49:899-907 pubmed publisher
    Leptospirosis is an endemic disease in Latin America, caused by pathogenic bacteria of the genus Leptospira. It is considered one of the main causes responsible for the negative economic impact on global livestock by causing reproductive ..
  57. Garshasbi V, Naddaf S, Aghighi Z, Hassan N, Pooya M, Mostafavi E. Leptospirosis in Caspian Sea littoral, Gilan Province, Iran. Acta Trop. 2018;181:11-15 pubmed publisher
    ..We also identified the common Leptospira species by sequencing a partial sequence of rrs gene. Out of the 128 sera examined by IFA, 25...
  58. Dittrich S, Rattanavong S, Lee S, Panyanivong P, Craig S, Tulsiani S, et al. Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study. Lancet Glob Health. 2015;3:e104-12 pubmed publisher
    ..meningitidis, Haemophilus influenzae, S suis) and O tsutsugamushi, Rickettsia typhi/Rickettsia spp, and Leptospira spp infections in blood or cerebrospinal fluid (CSF)...
  59. Lau C, Skelly C, Dohnt M, Smythe L. The emergence of Leptospira borgpetersenii serovar Arborea in Queensland, Australia, 2001 to 2013. BMC Infect Dis. 2015;15:230 pubmed publisher
    ..b>Leptospira borgpetersenii serovar Arborea has been emerging in Queensland since 2001, with increase in case numbers, the ..
  60. Barragán V, Olivas S, Keim P, Pearson T. Critical Knowledge Gaps in Our Understanding of Environmental Cycling and Transmission of Leptospira spp. Appl Environ Microbiol. 2017;83: pubmed publisher
    Exposure to soil or water contaminated with the urine of Leptospira-infected animals is the most common way in which humans contract leptospirosis...
  61. Muslich L, Villanueva S, Amran M, Segawa T, Saito M, Yoshida S. Characterization of Leptospira infection in suckling and weaning rat pups. Comp Immunol Microbiol Infect Dis. 2015;38:47-55 pubmed publisher
    Rats are known to be the most important reservoirs of Leptospira spp. However, the leptospiral dose and age at which rats become resistant to Leptospira infection are not yet well elucidated...
  62. Singh R, Khurana D, Mehta S, Choudhary A, Petluri G, Lal V. Cerebellar ataxia due to Leptospirosis- a case report. BMC Infect Dis. 2016;16:748 pubmed
    ..b>Leptospira serology showed high titres of IgM (ELISA) and MAT (microscopic agglutination test titre >1:800) ...
  63. Lopes Rocha M, Langone L, Miserocchi S, Giordano P, Guerra R. Detecting long-term temporal trends in sediment-bound metals in the western Adriatic (Mediterranean Sea). Mar Pollut Bull. 2017;124:270-285 pubmed publisher
    ..In contrast, an increase in trace metal accumulation in surficial sediment from the 2000s in front of the cities of Ancona and Bari suggested a recent local input of trace metals, probably due to harbor activities.
  64. Levett P. Systematics of leptospiraceae. Curr Top Microbiol Immunol. 2015;387:11-20 pubmed publisher
    ..The family Leptospiraceae comprises three genera: Leptospira Leptospira Leptonema Leptonema, and Turneriella Turneriella...
  65. Onuma S, Kantek D, Crawshaw Júnior P, Morato R, May Júnior J, Morais Z, et al. Detection of Leptospira spp. and Brucella abortus antibodies in free-living jaguars (Panthera onca) in two protected areas of northern Pantanal, Brazil. Rev Inst Med Trop Sao Paulo. 2015;57:177-80 pubmed publisher
    This study aimed to assess the exposure of free-living jaguars (Panthera onca) to Leptospira spp. and Brucella abortus in two conservation units in the Pantanal of Mato Grosso, Brazil...
  66. Simbizi V, Saulez M, Potts A, Lotter C, Gummow B. A study of leptospirosis in South African horses and associated risk factors. Prev Vet Med. 2016;134:6-15 pubmed publisher
    ..between potential risk factors and both seropositive horses to the predominant serovar Bratislava and to Leptospira spp. were statistically evaluated using univariate analysis and multivariable logistic regression models...
  67. Sohail M, Khan M, Ijaz M, Naseer O, Fatima Z, Ahmad A, et al. Seroprevalence and risk factor analysis of human leptospirosis in distinct climatic regions of Pakistan. Acta Trop. 2018;181:79-83 pubmed publisher
    ..of surroundings and history of cut and wound were found significantly associated with the seropositivity of Leptospira. The present study, first to uncover seroprevalence of human Leptospira in different climatic regions of ..
  68. Lau S, Wong J, Khor K, Roslan M, Abdul Rahman M, Bejo S, et al. Seroprevalence of Leptospirosis in Working Dogs. Top Companion Anim Med. 2017;32:121-125 pubmed publisher
    ..The duration of immunity in vaccinated dogs for Leptospira can last up to 13 months; however, there is no full crossprotection between the different serovars...
  69. Esteves L, Bulhões S, Branco C, Carreira T, Vieira M, Gomes Solecki M, et al. Diagnosis of Human Leptospirosis in a Clinical Setting: Real-Time PCR High Resolution Melting Analysis for Detection of Leptospira at the Onset of Disease. Sci Rep. 2018;8:9213 pubmed publisher
    Currently, direct detection of Leptospira can be done in clinical laboratories by conventional and by real-time PCR (qRT-PCR)...
  70. Guarnotta V, Amato M, Pivonello R, Arnaldi G, Ciresi A, Trementino L, et al. The degree of urinary hypercortisolism is not correlated with the severity of cushing's syndrome. Endocrine. 2017;55:564-572 pubmed publisher
    ..on 192 patients with active CS, consecutively presenting at the outpatients' clinic of the University Hospitals of Ancona, Naples, and Palermo...
  71. Fang F, Collins Emerson J, Heuer C, Hill F, Tisdall D, Wilson P, et al. Interlaboratory and between-specimen comparisons of diagnostic tests for leptospirosis in sheep and cattle. J Vet Diagn Invest. 2014;26:734-47 pubmed publisher
    ..93) for Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis (Hardjobovis) but moderate (kappa = 0...
  72. Parkash O, Shueb R. Diagnosis of Dengue Infection Using Conventional and Biosensor Based Techniques. Viruses. 2015;7:5410-27 pubmed publisher
    ..of dengue are indistinguishable from other infectious diseases such as malaria, chikungunya, rickettsia and leptospira. Therefore, prompt and accurate laboratory diagnostic test is urgently required for disease confirmation and ..
  73. Rodrigues T, Santos A, Lima A, Gomes D, Brites V. Anti-Leptospira spp. antibodies in Crotalus durissus collilineatus kept in captivity and its zoonotic relevance. Acta Trop. 2016;158:39-42 pubmed publisher
    ..Because it has been little studied in snakes, this study focused on determining the occurrence of anti-Leptospira spp...
  74. Gomes D, Ramos G, Alves V, Ciuffa A, Cuccato L, Dos Reis T, et al. Occurrence of anti-Leptospira spp. antibodies in Rhipidomys spp. from a forest fragment of the Brazilian Cerrado. Trop Anim Health Prod. 2017;49:555-559 pubmed publisher
    ..Given the necessity to investigate potential hosts of Leptospira spp., this study verified the prevalence of different serovars in the species of Rhipidomys spp...
  75. Williams S, Che X, Paulick A, Guo C, Lee B, Muller D, et al. New York City House Mice (Mus musculus) as Potential Reservoirs for Pathogenic Bacteria and Antimicrobial Resistance Determinants. MBio. 2018;9: pubmed publisher
    ..associated with human disease, and screening of kidney samples demonstrated genetic evidence of pathogenic Leptospira species...
  76. Zhang W, Zhang N, Wang W, Wang F, Gong Y, Jiang H, et al. Efficacy of cefepime, ertapenem and norfloxacin against leptospirosis and for the clearance of pathogens in a hamster model. Microb Pathog. 2014;77:78-83 pubmed publisher
    ..Although many antibiotics are active against multiple leptospira serovars in vitro, their efficacy in vivo is limited...
  77. Å»mudzki J, JabÅ‚oÅ„ski A, Nowak A, ZÄ™bek S, Arent Z, Bocian Å, et al. First overall report of Leptospira infections in wild boars in Poland. Acta Vet Scand. 2016;58:3 pubmed publisher
    ..For the first time, an extensive survey on the prevalence of Leptospira infections in Polish wild boars was performed...
  78. Mourembou G, Nzondo S, Ndjoyi Mbiguino A, Lekana Douki J, Kouna L, Matsiegui P, et al. Co-circulation of Plasmodium and Bacterial DNAs in Blood of Febrile and Afebrile Children from Urban and Rural Areas in Gabon. Am J Trop Med Hyg. 2016;95:123-32 pubmed publisher
    ..2% (1/410) only in febrile children. Coxiella burnetii, Borrelia spp., Bartonella spp., Leptospira spp., and Mycobacterium tuberculosis were not observed...
  79. Girault D, Soupé Gilbert M, Geroult S, Colot J, Goarant C. Isolation of Leptospira from blood culture bottles. Diagn Microbiol Infect Dis. 2017;88:17-19 pubmed publisher
    With the increasing use of real-time PCR techniques, Leptospira isolation has mostly been abandoned for the diagnosis of human leptospirosis...
  80. Colombo V, Gamietea I, Loffler S, Brihuega B, Beldomenico P. New host species for Leptospira borgpetersenii and Leptospira interrogans serovar Copenhageni. Vet Microbiol. 2018;215:90-92 pubmed publisher
    We investigated the presence of infection by Leptospira spp. in an assembly of Sigmodontinae rodents from the Paraná Delta, Argentina...
  81. Li S, Wang M, Ojcius D, Zhou B, Hu W, Liu Y, et al. Leptospira interrogans infection leads to IL-1β and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation. Microbes Infect. 2018;20:254-260 pubmed publisher
    Leptospirosis is a worldwide zoonosis caused by spirochetes from the genus Leptospira. Although there is a large diversity of clinical signs and symptoms, a severe inflammatory response is common to all leptospirosis patients...
  82. Cerqueira G, McBride A, Hartskeerl R, Ahmed N, Dellagostin O, Eslabão M, et al. Bioinformatics describes novel Loci for high resolution discrimination of leptospira isolates. PLoS ONE. 2010;5:e15335 pubmed publisher
    ..The development of multilocus sequence typing (MLST) schemes for Leptospira spp. is addressing this issue...
  83. Thaipadungpanit J, Thaipadunpanit J, Chierakul W, Wuthiekanun V, Limmathurotsakul D, Amornchai P, et al. Diagnostic accuracy of real-time PCR assays targeting 16S rRNA and lipL32 genes for human leptospirosis in Thailand: a case-control study. PLoS ONE. 2011;6:e16236 pubmed publisher
    ..The DSe of the rrs and lipL32 assays were high in the subgroup of 39 patients who were culture positive for Leptospira spp. (95% and 87%, respectively, p = 0.25)...
  84. Lehmann J, Matthias M, Vinetz J, Fouts D. Leptospiral pathogenomics. Pathogens. 2014;3:280-308 pubmed publisher
    Leptospirosis, caused by pathogenic spirochetes belonging to the genus Leptospira, is a zoonosis with important impacts on human and animal health worldwide...
  85. Ravishankar V, Ahmed A, Sivagnanam U, Muthuraman K, Karthikaichamy A, Wilson H, et al. Evolution of the RNase P RNA structural domain in Leptospira spp. Res Microbiol. 2014;165:813-25 pubmed publisher
    We have employed the RNase P RNA (RPR) gene, which is present as single copy in chromosome I of Leptospira spp. to investigate the phylogeny of structural domains present in the RNA subunit of the tRNA processing enzyme, RNase P...
  86. Palma E, Bufarini C. Robotized compounding of oncology drugs in a hospital pharmacy. Int J Pharm Compd. 2014;18:358-64 pubmed
    In 2005, the Pharmacy Department of the University Hospital of Ancona began collaboration with the engineers of the Loccioni group in order to realize a fully automated system for the preparation of cytostatic drugs, which could be safe ..
  87. Koizumi N, Izumiya H, Mu J, Arent Z, Okano S, Nakajima C, et al. Multiple-locus variable-number tandem repeat analysis of Leptospira interrogans and Leptospira borgpetersenii isolated from small feral and wild mammals in East Asia. Infect Genet Evol. 2015;36:434-440 pubmed publisher
    b>Leptospira spp. are the causative agents of a worldwide zoonosis, leptospirosis, maintained by various mammals...
  88. James Z, Borst A, Haitin Y, Frenz B, DiMaio F, Zagotta W, et al. CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel. Proc Natl Acad Sci U S A. 2017;114:4430-4435 pubmed publisher
    ..Here we used cryoEM to determine the structure of the intact LliK CNG channel isolated from Leptospira licerasiae-which shares sequence similarity to eukaryotic CNG and HCN channels-in the presence of a ..
  89. Cortizo P, Loureiro A, Martins G, do Rodrigues P, Faria B, Lilenbaum W, et al. Risk factors to incidental leptospirosis and its role on the reproduction of ewes and goats of Espírito Santo state, Brazil. Trop Anim Health Prod. 2015;47:231-5 pubmed publisher
    ..6 more chances of having premature births when compared to the seronegative ones. It can be concluded that Leptospira infection, mainly those caused incidental strains (such as Icterohaemorrhagiae serogroup), is a significant ..
  90. Xu J, Guo Y, Nakamura S, Islam M, Tomioka R, Yoneyama H, et al. Mannose-binding lectin impairs Leptospira activity through the inhibitory effect on the motility of cell. Microbiol Res. 2015;171:21-5 pubmed publisher
    ..in the serum level of MBL has been confirmed during leptospirosis, which caused by a pathogenic spirochete, Leptospira. Leptospira has a fascinating locomotion pattern, which simultaneously gyrating and swimming forward, such ..
  91. Lehmann J, Corey V, Ricaldi J, Vinetz J, Winzeler E, Matthias M. Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation. Am J Trop Med Hyg. 2016;94:302-13 pubmed publisher
    ..To identify virulence-related genes in Leptospira interrogans, we delineated cumulative genome changes that occurred during serial in vitro passage of a highly ..
  92. Puca E, Pilaca A, Kalo T, Pipero P, Bino S, Hysenaj Z, et al. Ocular and cutaneous manifestation of leptospirosis acquired in Albania: A retrospective analysis with implications for travel medicine. Travel Med Infect Dis. 2016;14:143-7 pubmed publisher
    ..of leptospirosis, confirmed with ELISA (enzyme linked immunoassay) positive for IgM antibodies against Leptospira. There were 89.7% males (n = 96) and 10.2% females (n = 11)...