Lyme disease spirochete

Summary

Alias: Borrelia burgdorferi, Borrelia burgdorferi sensu stricto, Borrelia burgdorferi Johnson et al. 1984 emend. Baranton et al. 1992, Borrelia burdorferi, Borrelia burgdorffragment

Top Publications

  1. Akins D, Bourell K, Caimano M, Norgard M, Radolf J. A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state. J Clin Invest. 1998;101:2240-50 pubmed
    There is now substantial evidence that Borrelia burgdorferi, the Lyme disease spirochete, undergoes major alterations in antigenic composition as it cycles between its arthropod and mammalian hosts. In this report, we cultivated B...
  2. Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y. Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library. Antibiotics (Basel). 2015;4:397-410 pubmed publisher
    ..These studies may have implications for developing more effective treatments of Lyme disease. ..
  3. Wang H, Wu S, Jiang L, Xiao R, Li T, Mei L, et al. Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens. Parasit Vectors. 2018;11:442 pubmed publisher
    ..hemorrhagic disease virus of deer, Coxiella burnetii, African swine fever virus, West Nile fever virus, Borrelia burgdorferi, vesicular stomatitis virus, Rift Valley fever virus, Ebola virus and Schmalenberg's disease virus, and ..
  4. Scorza A, Lappin M. Prevalence of Selected Zoonotic and Vector-Borne Agents in Dogs and Cats on the Pine Ridge Reservation. Vet Sci. 2017;4: pubmed publisher
    ..Dog sera (n = 82) were tested for antibodies against T. gondii, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum and D. immitis antigen...
  5. Mali S, Mitchell M, Havis S, Bodunrin A, Rangel J, Olson G, et al. A Proteomic Signature of Dormancy in the Actinobacterium Micrococcus luteus. J Bacteriol. 2017;199: pubmed publisher
    ..tuberculosis, Staphylococcus aureus, Treponema pallidum (syphilis), and Borrelia burgdorferi (Lyme disease), curtail metabolic activity to survive external stresses, including antibiotics...
  6. Bush L, Vazquez Pertejo M. Tick borne illness-Lyme disease. Dis Mon. 2018;64:195-212 pubmed publisher
    Lyme disease is the most commonly reported tick-borneillness in the United States. Thecausative spirochete, Borrelia burgdorferi is transmitted by 4 species of Ixodes tick species...
  7. Alfredsson M, Olafsson E, Eydal M, Unnsteinsdóttir E, Hansford K, Wint W, et al. Surveillance of Ixodes ricinus ticks (Acari: Ixodidae) in Iceland. Parasit Vectors. 2017;10:466 pubmed publisher
    Ixodes ricinus is a three-host tick, a principal vector of Borrelia burgdorferi (s.l.) and one of the main vectors of tick-borne encephalitis (TBE) virus. Iceland is located in the North Atlantic Ocean with subpolar oceanic climate...
  8. Szekeres S, Coipan E, Rigó K, Majoros G, Jahfari S, Sprong H, et al. Eco-epidemiology of Borrelia miyamotoi and Lyme borreliosis spirochetes in a popular hunting and recreational forest area in Hungary. Parasit Vectors. 2015;8:309 pubmed publisher
    Borrelia miyamotoi, the newly discovered human pathogenic relapsing fever spirochete, and Borrelia burgdorferi sensu lato are maintained in natural rodent populations. The aim of this study was to investigate the natural cycle of B...
  9. Gofton A, Oskam C, Lo N, Beninati T, Wei H, McCarl V, et al. Inhibition of the endosymbiont "Candidatus Midichloria mitochondrii" during 16S rRNA gene profiling reveals potential pathogens in Ixodes ticks from Australia. Parasit Vectors. 2015;8:345 pubmed publisher
    ..Ongoing controversy about the presence of Borrelia burgdorferi sensu lato (the aetiological agent of Lyme disease) in Australia increases the need to accurately identify ..

More Information

Publications253 found, 100 shown here

  1. Pantchev N, Pluta S, Huisinga E, Nather S, Scheufelen M, Vrhovec M, et al. Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis. Parasitol Res. 2015;114 Suppl 1:S19-54 pubmed publisher
    ..The widespread European tick species Ixodes ricinus represents an important vector for spirochaetes of the Borrelia burgdorferi sensu lato group and Rickettsiales such as Anaplasma phagocytophilum...
  2. Figueredo L, Sales K, Deuster K, Pollmeier M, Otranto D, Dantas Torres F. Exposure to vector-borne pathogens in privately owned dogs living in different socioeconomic settings in Brazil. Vet Parasitol. 2017;243:18-23 pubmed publisher
    ..In particular, antibodies to Anaplasma spp., Borrelia burgdorferi sensu lato, and Ehrlichia spp...
  3. Suh G, Ahn K, Ahn J, Kim H, Leutenegger C, Shin S. Serological and molecular prevalence of canine vector-borne diseases (CVBDs) in Korea. Parasit Vectors. 2017;10:146 pubmed publisher
    ..2%), followed by Anaplasma phagocytophilum (15.6%), Ehrlichia canis (4.7%) whereas Borrelia burgdorferi showed the lowest prevalence (1.1%)...
  4. Hutchinson M, Strohecker M, Simmons T, Kyle A, Helwig M. Prevalence Rates of Borrelia burgdorferi (Spirochaetales: Spirochaetaceae), Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae), and Babesia microti (Piroplasmida: Babesiidae) in Host-Seeking Ixodes scapularis (Acari: Ixodidae) from Pennsylvan. J Med Entomol. 2015;52:693-8 pubmed publisher
    The etiological agents responsible for Lyme disease (Borrelia burgdorferi), human granulocytic anaplasmosis (Anaplasma phagocytophilum), and babesiosis (Babesia microti) are primarily transmitted by the blacklegged tick, Ixodes scapularis ..
  5. Little S, Barrett A, Nagamori Y, Herrin B, Normile D, Heaney K, et al. Ticks from cats in the United States: Patterns of infestation and infection with pathogens. Vet Parasitol. 2018;257:15-20 pubmed publisher
    ..Assay of ticks removed from cats revealed I. scapularis were infected with Borrelia burgdorferi (25.7%) and Anaplasma phagocytophilum (4.4%); A. americanum were infected with Ehrlichia chaffeensis (1...
  6. Da Rold G, Ravagnan S, Soppelsa F, Porcellato E, Soppelsa M, Obber F, et al. Ticks are more suitable than red foxes for monitoring zoonotic tick-borne pathogens in northeastern Italy. Parasit Vectors. 2018;11:137 pubmed publisher
    ..264), pooled larvae (n?=?330) and nymphs (n?=?1984) were screened for tick-borne encephalitis virus, Borrelia burgdorferi (s.l.), Rickettsia spp., Babesia spp...
  7. Eisen L. Pathogen transmission in relation to duration of attachment by Ixodes scapularis ticks. Ticks Tick Borne Dis. 2018;9:535-542 pubmed publisher
    ..babesiosis); and multiple bacterial disease agents including Anaplasma phagocytophilum (anaplasmosis), Borrelia burgdorferi and Borrelia mayonii (Lyme disease), Borrelia miyamotoi (relapsing fever-like illness, named Borrelia ..
  8. Zhang Y, Wei Z, Li J, Liu P. Molecular pathogenesis of lymphomas of mucosa-associated lymphoid tissue--from (auto)antigen driven selection to the activation of NF-κB signaling. Sci China Life Sci. 2015;58:1246-55 pubmed publisher
    ..The infection of certain pathogens, such as Helicobacter pylori, Chlamydophila psittaci, Borrelia burgdorferi, hepatitis C virus, or certain autoantigens cause these sites to generate a germinal center called the "..
  9. Drecktrah D, Lybecker M, Popitsch N, Rescheneder P, Hall L, Samuels D. The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation. PLoS Pathog. 2015;11:e1005160 pubmed publisher
    As the Lyme disease bacterium Borrelia burgdorferi traverses its enzootic cycle, alternating between a tick vector and a vertebrate host, the spirochete must adapt and persist in the tick midgut under prolonged nutrient stress between ..
  10. Krawczyk A, van Leeuwen A, Jacobs Reitsma W, Wijnands L, Bouw E, Jahfari S, et al. Presence of zoonotic agents in engorged ticks and hedgehog faeces from Erinaceus europaeus in (sub) urban areas. Parasit Vectors. 2015;8:210 pubmed publisher
    ..Ticks were screened individually for presence of Borrelia burgdorferi sensu lato, B...
  11. Detmer S, Bouljihad M, Hayden D, Schefers J, Armien A, Wünschmann A. Fatal pyogranulomatous myocarditis in 10 Boxer puppies. J Vet Diagn Invest. 2016;28:144-9 pubmed publisher
    ..All dogs were positive for Borrelia burgdorferi on immunohistochemistry (IHC)...
  12. Graham C, Maes S, Hojgaard A, Fleshman A, Sheldon S, Eisen R. A molecular algorithm to detect and differentiate human pathogens infecting Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae). Ticks Tick Borne Dis. 2018;9:390-403 pubmed publisher
    ..scapularis and I. pacificus nymphs including Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi sensu stricto, Borrelia mayonii, and Borrelia miyamotoi...
  13. Buczek A, Ciura D, Bartosik K, ZajÄ…c Z, Kulisz J. Threat of attacks of Ixodes ricinus ticks (Ixodida: Ixodidae) and Lyme borreliosis within urban heat islands in south-western Poland. Parasit Vectors. 2014;7:562 pubmed publisher
    ..borreliosis risk in the region was determined on the basis of the results of research on the prevalence of Borrelia burgdorferi s.l. in ticks and reports from sanitary-epidemiological stations. In total, 2061 I...
  14. Jahfari S, Hofhuis A, Fonville M, van der Giessen J, van Pelt W, Sprong H. Molecular Detection of Tick-Borne Pathogens in Humans with Tick Bites and Erythema Migrans, in the Netherlands. PLoS Negl Trop Dis. 2016;10:e0005042 pubmed publisher
    ..Half of the ticks removed from humans tested positive for Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum, Candidatus Neoehrlichia mikurensis, Rickettsia helvetica, Rickettsia ..
  15. Yu P, Niu Q, Liu Z, Yang J, Chen Z, Guan G, et al. Molecular epidemiological surveillance to assess emergence and re-emergence of tick-borne infections in tick samples from China evaluated by nested PCRs. Acta Trop. 2016;158:181-188 pubmed publisher
    ..locations in eight provinces of China and subjected to screening for tick-borne pathogens, including Borrelia burgdorferi sensu lato, Ehrlichia spp., Rickettsia spp., Babesia/Theileria spp...
  16. Starkey L, Newton K, Brunker J, Crowdis K, Edourad E, Meneus P, et al. Prevalence of vector-borne pathogens in dogs from Haiti. Vet Parasitol. 2016;224:7-12 pubmed publisher
    ..in 37 (17.6%), and antigen of Dirofilaria immitis in 55 (26.2%); antibodies to Borrelia burgdorferi were not detected in any sample...
  17. Rogovskyy A, Batool M, Gillis D, Holman P, Nebogatkin I, Rogovska Y, et al. Diversity of Borrelia spirochetes and other zoonotic agents in ticks from Kyiv, Ukraine. Ticks Tick Borne Dis. 2018;9:404-409 pubmed publisher
    Lyme borreliosis (LB) is caused by tick-borne spirochetes of the Borrelia burgdorferi sensu lato complex...
  18. Foley J, Nieto N. The ecology of tick-transmitted infections in the redwood chipmunk (Tamias ochrogenys). Ticks Tick Borne Dis. 2011;2:88-93 pubmed publisher
    ..ticks, and are reservoir competent for Borrelia burgdorferi. We hypothesized that chipmunks could maintain tick-borne disease on the forest floor while also ..
  19. Mays S, Hendricks B, Paulsen D, Houston A, Trout Fryxell R. Prevalence of five tick-borne bacterial genera in adult Ixodes scapularis removed from white-tailed deer in western Tennessee. Parasit Vectors. 2014;7:473 pubmed publisher
    ..causal agents of anaplasmosis (Anaplasma phagocytophilum), babesiosis (Babesia microti), and borreliosis (Borrelia burgdorferi and B. miyamotoi)...
  20. Koh F, Panchadcharam C, Tay S. Vector-Borne Diseases in Stray Dogs in Peninsular Malaysia and Molecular Detection of Anaplasma and Ehrlichia spp. from Rhipicephalus sanguineus (Acari: Ixodidae) Ticks. J Med Entomol. 2016;53:183-7 pubmed publisher
    ..5%) and four (9.3%) of 43 dog samples, respectively. None of the dog blood samples were positive for Borrelia burgdorferi and Dirofilaria immitis. DNA of E. canis and A. phagocytophilum was detected in 12 (25.5%) and two (4...
  21. Płusa T. [History of the study, epidemiology of the disease and characterization of Borrelia burgdorferi infection]. Pol Merkur Lekarski. 2017;43:99-103 pubmed
    ..However, a number of lipoproteins have been defined and some of them may be factors contributing to the innate immune system...
  22. Mayne P, Song S, Shao R, Burke J, Wang Y, Roberts T. Evidence for Ixodes holocyclus (Acarina: Ixodidae) as a vector for human lyme Borreliosis infection in Australia. J Insect Sci. 2014;14:271 pubmed publisher
    ..b>Borrelia burgdorferi sensu stricto (Spirochaetales: Spirochaetaceae) and sensu lato are closely related spirochetal species that are ..
  23. Alho A, Pita J, Amaro A, Amaro F, Schnyder M, Grimm F, et al. Seroprevalence of vector-borne pathogens and molecular detection of Borrelia afzelii in military dogs from Portugal. Parasit Vectors. 2016;9:225 pubmed publisher
    ..and Toscana virus. Serum was tested by polymerase chain reaction for Borrelia burgdorferi (sensu lato), with sequencing of the DNA products...
  24. Heylen D, Fonville M, Docters van Leeuwen A, Stroo A, Duisterwinkel M, van Wieren S, et al. Pathogen communities of songbird-derived ticks in Europe's low countries. Parasit Vectors. 2017;10:497 pubmed publisher
    ..In the present study, we aim to identify members of a pathogen community [Borrelia burgdorferi (s.l.), B. miyamotoi, 'Ca...
  25. Nader J, Król N, Pfeffer M, Ohlendorf V, Marklewitz M, Drosten C, et al. The diversity of tick-borne bacteria and parasites in ticks collected from the Strandja Nature Park in south-eastern Bulgaria. Parasit Vectors. 2018;11:165 pubmed publisher
    ..b>Borrelia burgdorferi (s.l.), Rickettsia spp...
  26. Koetsveld J, Tijsse Klasen E, Herremans T, Hovius J, Sprong H. Serological and molecular evidence for spotted fever group Rickettsia and Borrelia burgdorferi sensu lato co-infections in The Netherlands. Ticks Tick Borne Dis. 2016;7:371-7 pubmed publisher
    ..We show that of all the Borrelia burgdorferi s.l.-positive ticks, 25% were co-infected with rickettsiae. Predominantly R. helvetica was detected while R...
  27. Rigaud E, Jaulhac B, Garcia Bonnet N, Hunfeld K, Femenia F, Huet D, et al. Seroprevalence of seven pathogens transmitted by the Ixodes ricinus tick in forestry workers in France. Clin Microbiol Infect. 2016;22:735.e1-9 pubmed publisher
    ..The global seroprevalence estimated for the seven pathogens studied was 14.1% (419/2975) for Borrelia burgdorferi sl, 5.7% (164/2908) for Francisella tularensis, 2.3% (68/2941) for tick-borne encephalitis virus, 1...
  28. Lauzi S, Maia J, Epis S, Marcos R, Pereira C, Luzzago C, et al. Molecular detection of Anaplasma platys, Ehrlichia canis, Hepatozoon canis and Rickettsia monacensis in dogs from Maio Island of Cape Verde archipelago. Ticks Tick Borne Dis. 2016;7:964-969 pubmed publisher
    ..was amplified from the blood of one dog. None of the dogs were positive for Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, Midichloria mitochondrii, Bartonella spp., Babesia spp. or Theileria spp. Fifty-four (35...
  29. Feng J, Shi W, Miklossy J, Tauxe G, McMeniman C, Zhang Y. Identification of Essential Oils with Strong Activity against Stationary Phase Borrelia burgdorferi. Antibiotics (Basel). 2018;7: pubmed publisher
    ..Pers. fruits essential oils all had visible growth during subculture. Future studies are needed to determine if these highly active essential oils could eradicate persistent B. burgdorferi infection in vivo. ..
  30. Norte A, Costantini D, Araújo P, Eens M, Ramos J, Heylen D. Experimental infection by microparasites affects the oxidative balance in their avian reservoir host the blackbird Turdus merula. Ticks Tick Borne Dis. 2018;9:720-729 pubmed publisher
    ..We tested this hypothesis for tick-borne Borrelia burgdorferi sensu lato (s.l...
  31. Kurilshikov A, Fomenko N, Stronin O, Tikunov A, Kabilov M, Tupikin A, et al. Complete Genome Sequencing of Borrelia valaisiana and Borrelia afzelii Isolated from Ixodes persulcatus Ticks in Western Siberia. Genome Announc. 2014;2: pubmed publisher
    Lyme disease, caused by bacteria of the Borrelia burgdorferi sensu lato complex, is the most frequent tick-borne infection in Eurasia...
  32. Arnold W, Savage C, Antonicello A, Stevenson B. Apparent role for Borrelia burgdorferi LuxS during mammalian infection. Infect Immun. 2015;83:1347-53 pubmed publisher
    The Lyme disease spirochete, Borrelia burgdorferi, controls protein expression patterns during its tick-mammal infection cycle. Earlier studies demonstrated that B...
  33. Bauvin O, Schmutz J, de Martino S, Busato T, Cribier B, Barbaud A, et al. A foot tumour as late cutaneous Lyme borreliosis: a new entity?. Br J Dermatol. 2017;177:1127-1130 pubmed publisher
    ..In fact, the patient recalled tick bites 2 or 3 years before. Borrelia burgdorferi (Bb) serology was highly positive and a polymerase chain reaction analysis on the skin biopsy detected Bb ..
  34. Brandt K, Gilmore R. Immunization of mice with Borrelia burgdorferi lp54 gene encoded recombinant proteins does not provide protection against tick transmitted infectious challenge. Vaccine. 2017;35:5310-5313 pubmed publisher
    The Borrelia burgdorferi outer surface membrane proteins BBA65, BBA66, BBA69, BBA70, and BBA73 were tested for their ability to confer protection against B. burgdorferi infection challenge...
  35. Zhang X, Yang Z, Lu B, Ma X, Zhang C, Xu H. The composition and transmission of microbiome in hard tick, Ixodes persulcatus, during blood meal. Ticks Tick Borne Dis. 2014;5:864-70 pubmed publisher
    ..We found that B. garinii and B. afzelii are the predominant genospecies of the Lyme disease spirochete in I. persulcatus ticks...
  36. Schreiber C, Krücken J, Beck S, Maaz D, Pachnicke S, Krieger K, et al. Pathogens in ticks collected from dogs in Berlin/Brandenburg, Germany. Parasit Vectors. 2014;7:535 pubmed publisher
    ..2% of I. hexagonus. Subsequent genospecies analysis revealed Borrelia afzelii, Borrelia garinii, Borrelia burgdorferi sensu stricto and Borrelia miyamotoi. Simultanous presence of more than one pathogen was found in 20% of I...
  37. Lasky C, Olson R, Brown C. Macrophage Polarization during Murine Lyme Borreliosis. Infect Immun. 2015;83:2627-35 pubmed publisher
    Infection of C3H mice with Borrelia burgdorferi, the causative agent of Lyme disease, reliably produces an infectious arthritis and carditis that peak around 3 weeks postinfection and then spontaneously resolve...
  38. Parthasarathy G, Philipp M. Inflammatory mediator release from primary rhesus microglia in response to Borrelia burgdorferi results from the activation of several receptors and pathways. J Neuroinflammation. 2015;12:60 pubmed publisher
    In previous studies, neurons were documented to undergo apoptosis in the presence of microglia and live Borrelia burgdorferi, but not with either agent alone...
  39. Sharma B, Brown A, Matluck N, Hu L, Lewis K. Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells. Antimicrob Agents Chemother. 2015;59:4616-24 pubmed publisher
    b>Borrelia burgdorferi is the causative agent of Lyme disease, which affects an estimated 300,000 people annually in the United States...
  40. Elsner R, Hastey C, Olsen K, Baumgarth N. Suppression of Long-Lived Humoral Immunity Following Borrelia burgdorferi Infection. PLoS Pathog. 2015;11:e1004976 pubmed publisher
    Lyme Disease caused by infection with Borrelia burgdorferi is an emerging infectious disease and already by far the most common vector-borne disease in the U.S. Similar to many other infections, infection with B...
  41. Zajkowska J, Lelental N, Kulakowska A, Mroczko B, Pancewicz S, Bucki R, et al. Application of multiplexing technology to the analysis of the intrathecally released immunoglobulins against B. burgdorferi antigens in neuroborreliosis. Immunol Lett. 2015;168:58-63 pubmed publisher
    ..neuroborreliosis (LNB) is an infectious disease of the nervous system caused by the tick-borne spirochete Borrelia burgdorferi. The presence of B...
  42. Rudolf I, Betášová L, Bischof V, Venclíková K, Blažejová H, Mendel J, et al. Molecular survey of arthropod-borne pathogens in sheep keds (Melophagus ovinus), Central Europe. Parasitol Res. 2016;115:3679-82 pubmed publisher
    ..All investigated keds were negative for flaviviruses, phleboviruses, bunyaviruses, Borrelia burgdorferi, Rickettsia spp., Anaplasma phagocytophilum, "Candidatus Neoehrlichia mikurensis," and Babesia spp...
  43. Henkel K, Lange P, Eiffert H, Nau R, Spreer A. Infections in the differential diagnosis of Bell's palsy: a plea for performing CSF analysis. Infection. 2017;45:147-155 pubmed publisher
    ..The predominant infectious agents were Borrelia burgdorferi, VZV and HSV, and in most of these cases diagnosis relied on the findings of CSF analysis...
  44. Goddard J. Not All Erythema Migrans Lesions Are Lyme Disease. Am J Med. 2017;130:231-233 pubmed publisher
    ..then submitted to the Centers for Disease Control and Prevention for testing for the agent of Lyme disease, Borrelia burgdorferi. The patient was evaluated by an internist 7 weeks later...
  45. Waiß C, Kindler W, Ströbele B, Aspöck C, Oberndorfer S. [CXCL-13 as a biomarker in the diagnostics of neuroborreliosis]. Nervenarzt. 2017;88:635-641 pubmed publisher
    ..We conclude from these results that CXCL-13 represents a valuable biomarker for the exclusion of untreated NB, although with limited specificity. ..
  46. Koetsveld J, Draga R, Wagemakers A, Manger A, Oei A, Visser C, et al. In Vitro Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..i>miyamotoi strains isolated on two different continents (Asia and North America), two Borrelia burgdorferisensu lato strains, and one Borrelia hermsii isolate for purposes of comparison...
  47. Rezkova M, Kopecky J. Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period. Folia Parasitol (Praha). 2017;64: pubmed publisher
    ..In the skin, it contributes to immune containment of tick-transmitted pathogens like Borrelia burgdorferi. In the saliva of some tick species, active compounds are present that inhibit detection of TNF in specific ..
  48. Tolkki L, Hokynar K, Meri S, Panelius J, Puolakkainen M, Ranki A. Granuloma Annulare and Morphea: Correlation with Borrelia burgdorferi Infections and Chlamydia-related Bacteria. Acta Derm Venereol. 2018;98:355-360 pubmed publisher
    ..Biopsies were tested for cutaneous Borrelia burgdorferi DNA using PCR...
  49. Pulzova L, Bhide M. Outer surface proteins of Borrelia: peerless immune evasion tools. Curr Protein Pept Sci. 2014;15:75-88 pubmed
    Lyme borreliosis (LB), caused by Borrelia burgdorferi (B.b.), is the most frequently diagnosed tick-borne zoonosis in temperate zones of the Northern hemisphere...
  50. Pańczuk A, Kozioł Montewka M, Tokarska Rodak M. Exposure to ticks and seroprevalence of Borrelia burgdorferi among a healthy young population living in the area of southern Podlasie, Poland. Ann Agric Environ Med. 2014;21:512-7 pubmed publisher
    The objective of the study was assessment of risk of infection with Borrelia burgdorferi in the area of southern Podlasie in Poland, near the border with Belarus, by analysis of post-exposure procedure, and evaluation of asymptomatic ..
  51. Hsu H, Chen C, Nenninger A, Holz L, Baldwin C, Telfer J. WC1 is a hybrid γδ TCR coreceptor and pattern recognition receptor for pathogenic bacteria. J Immunol. 2015;194:2280-8 pubmed publisher
    ..and Borrelia burgdorferi, but not with Escherichia coli or Staphylococcus aureus...
  52. Wallace J, Nicholson W, Perniciaro J, Vaughn M, Funkhouser S, Juliano J, et al. Incident Tick-Borne Infections in a Cohort of North Carolina Outdoor Workers. Vector Borne Zoonotic Dis. 2016;16:302-8 pubmed publisher
    ..Titers against Borrelia burgdorferi were measured at baseline and after 2 years (n = 90)...
  53. Jutras B, Scott M, Parry B, Biboy J, Gray J, Vollmer W, et al. Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells. Proc Natl Acad Sci U S A. 2016;113:9162-70 pubmed publisher
    ..Here, using quantitative microscopy to track peptidoglycan cell-wall synthesis, we found that the Lyme disease spirochete Borrelia burgdorferi displays a complex pattern of growth. B...
  54. Durand J, Herrmann C, Genné D, Sarr A, Gern L, Voordouw M. Multistrain Infections with Lyme Borreliosis Pathogens in the Tick Vector. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..vector-borne disease in the Northern Hemisphere and is caused by spirochete bacteria that belong to the Borrelia burgdorferi sensu lato species complex...
  55. Adams P, Flores Avile C, Popitsch N, Bilusic I, Schroeder R, Lybecker M, et al. In vivo expression technology and 5' end mapping of the Borrelia burgdorferi transcriptome identify novel RNAs expressed during mammalian infection. Nucleic Acids Res. 2017;45:775-792 pubmed publisher
    b>Borrelia burgdorferi, the bacterial pathogen responsible for Lyme disease, modulates its gene expression profile in response to the environments encountered throughout its tick-mammal infectious cycle. To begin to characterize the B...
  56. Riordan J, Mitra A. Regulation of Escherichia coli Pathogenesis by Alternative Sigma Factor N. EcoSal Plus. 2017;7: pubmed publisher
    ..In enterohemorrhagic Escherichia coli (EHEC) O157, Salmonella enterica, and Borrelia burgdorferi, regulation of virulence by ?N requires another alternative sigma factor, ?S, yet ..
  57. Grove A, Liveris D, Iyer R, Petzke M, Rudman J, Caimano M, et al. Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete. MBio. 2017;8: pubmed publisher
    ..sigma factor RpoS plays a key role modulating gene expression in Borrelia burgdorferi, the Lyme disease spirochete, by transcribing mammalian host-phase genes and repressing ?70-dependent genes required within ..
  58. Honig V, Carolan H, Vavrušková Z, Massire C, Mosel M, Crowder C, et al. Broad-range survey of vector-borne pathogens and tick host identification of Ixodes ricinus from Southern Czech Republic. FEMS Microbiol Ecol. 2017;93: pubmed publisher
    ..b>Borrelia burgdorferi sensu lato spirochetes were the most common pathogen detected in the ticks; 21% of ticks were positive for ..
  59. Egizi A, Roegner V, Faraji A, Healy S, Schulze T, Jordan R. A historical snapshot of Ixodes scapularis-borne pathogens in New Jersey ticks reflects a changing disease landscape. Ticks Tick Borne Dis. 2018;9:418-426 pubmed publisher
    ..Infection with Borrelia burgdorferi sensu stricto, Babesia microti, and Anaplasma phagocytophilum (the agents of Lyme disease, human babesiosis, and ..
  60. Rosa R, Andreo V, Tagliapietra V, Baráková I, Arnoldi D, Hauffe H, et al. Effect of Climate and Land Use on the Spatio-Temporal Variability of Tick-Borne Bacteria in Europe. Int J Environ Res Public Health. 2018;15: pubmed publisher
    The incidence of tick-borne diseases caused by Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Rickettsia spp. has been rising in Europe in recent decades...
  61. Azzag N, Petit E, Gandoin C, Bouillin C, Ghalmi F, Haddad N, et al. Prevalence of select vector-borne pathogens in stray and client-owned dogs from Algiers. Comp Immunol Microbiol Infect Dis. 2015;38:1-7 pubmed publisher
    ..Antibodies to Anaplasma phagocytophilum were the most prevalent at 47.7%, followed by Borrelia burgdorferi s.l. at 37.6%, Ehrlichia canis at 30.0%, Bartonella henselae at 32.4% and Bartonella vinsonii subsp...
  62. Becker M, Felsberger A, Frenzel A, Shattuck W, Dyer M, Kügler J, et al. Application of M13 phage display for identifying immunogenic proteins from tick (Ixodes scapularis) saliva. BMC Biotechnol. 2015;15:43 pubmed publisher
    Ticks act as vectors for a large number of different pathogens, perhaps most notably Borrelia burgdorferi, the causative agent of Lyme disease. The most prominent tick vector in the United States is the blacklegged tick, Ixodes scapularis...
  63. Rogovskyy A, Gillis D, Ionov Y, Gerasimov E, Zelikovsky A. Antibody Response to Lyme Disease Spirochetes in the Context of VlsE-Mediated Immune Evasion. Infect Immun. 2017;85: pubmed publisher
    Lyme disease (LD), the most prevalent tick-borne illness in North America, is caused by Borrelia burgdorferi The long-term survival of B. burgdorferi spirochetes in the mammalian host is achieved though VlsE-mediated antigenic variation...
  64. Łuczaj W, Domingues P, Domingues M, Pancewicz S, Skrzydlewska E. Phospholipidomic Analysis Reveals Changes in Sphingomyelin and Lysophosphatidylcholine Profiles in Plasma from Patients with Neuroborreliosis. Lipids. 2017;52:93-98 pubmed publisher
    ..dangerous manifestation of LD is neuroborreliosis associated with invasion of the central nervous system by Borrelia burgdorferi. Phospholipids (PL) and their metabolites are involved in inflammation, which plays a dominant, but still ..
  65. Caol S, Divers T, Crisman M, Chang Y. In vitro susceptibility of Borrelia burgdorferi isolates to three antibiotics commonly used for treating equine Lyme disease. BMC Vet Res. 2017;13:293 pubmed publisher
    ..macrolides or beta lactam antibiotics that have low minimum inhibitory concentrations (MIC) against Borrelia burgdorferi. Horses with Lyme disease may require long-term treatment making frequent intravenous or intramuscular ..
  66. Carreras González A, Navasa N, Martín Ruiz I, Lavín J, Azkargorta M, Atondo E, et al. A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi. Emerg Microbes Infect. 2018;7:19 pubmed publisher
  67. Blazejak K, Raulf M, Janecek E, Jordan D, Fingerle V, Strube C. Shifts in Borrelia burgdorferi (s.l.) geno-species infections in Ixodes ricinus over a 10-year surveillance period in the city of Hanover (Germany) and Borrelia miyamotoi-specific Reverse Line Blot detection. Parasit Vectors. 2018;11:304 pubmed publisher
    Lyme borreliosis caused by spirochetes of the Borrelia burgdorferi (sensu lato) complex is still the most common tick-borne disease in Europe, posing a considerable threat to public health...
  68. Molloy E, Casjens S, Cox C, Maxson T, Ethridge N, Margos G, et al. Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family. BMC Microbiol. 2015;15:141 pubmed publisher
    ..clusters, naturally truncated SLS-like precursors were found in the genomes of three Lyme disease-causing Borrelia burgdorferi sensu lato (Bbsl) strains. Although unable to restore hemolysis in SLS-deficient S...
  69. Ebani V, Poli A, Rocchigiani G, Bertelloni F, Nardoni S, Papini R, et al. Serological survey on some pathogens in wild brown hares (Lepus europaeus) in Central Italy. Asian Pac J Trop Med. 2016;9:465-9 pubmed publisher
    ..europaeus), pallas] to Anaplasma phagocytophilum (A. phagocytophilum), Borrelia burgdorferi (B. burgdorferi) sensu lato, Encephalitozoon cuniculi (E. cuniculi), Leishmania sp...
  70. Sonnleitner S, Margos G, Wex F, Simeoni J, Zelger R, Schmutzhard E, et al. Human seroprevalence against Borrelia burgdorferi sensu lato in two comparable regions of the eastern Alps is not correlated to vector infection rates. Ticks Tick Borne Dis. 2015;6:221-7 pubmed publisher
    ..In the Tyrols, the continental divide delimitates areas with high seroprevalences of IgG antibodies against Borrelia burgdorferi sensu lato in the North (7.2%) from areas with low seroprevalences in the South (1.5%)...
  71. Bernard Q, Jaulhac B, Boulanger N. In Vitro Models of Cutaneous Inflammation. Methods Mol Biol. 2018;1690:319-327 pubmed publisher
    ..borreliosis since it is the first interface between the Ixodes tick and the host during the inoculation of Borrelia burgdorferi sensu lato...
  72. Ehrmann S, Ruyts S, Scherer Lorenzen M, Bauhus J, Brunet J, Cousins S, et al. Habitat properties are key drivers of Borrelia burgdorferi (s.l.) prevalence in Ixodes ricinus populations of deciduous forest fragments. Parasit Vectors. 2018;11:23 pubmed publisher
    ..In the light of these findings, climate change may be of little concern for LB risk at local scales, but this should be evaluated further. ..
  73. Mead P. Epidemiology of Lyme disease. Infect Dis Clin North Am. 2015;29:187-210 pubmed publisher
    Lyme disease is the most common vector-borne illness in North America and Europe. The etiologic agent, Borrelia burgdorferi sensu lato, is transmitted to humans by certain species of Ixodes ticks, which are found widely in temperate ..
  74. Wang Y, Mu L, Zhang K, Yang M, Zhang L, Du J, et al. A broad-range survey of ticks from livestock in Northern Xinjiang: changes in tick distribution and the isolation of Borrelia burgdorferi sensu stricto. Parasit Vectors. 2015;8:449 pubmed publisher
    ..Additionally, this study is the first to isolate B. burgdorferi sensu stricto in Hy. asiaticum asiaticum, H. punctata, D. nuttalli and D. marginatus ticks from domestic animals. These ticks may transmit borreliosis among livestock. ..
  75. Eisen L, Eisen R. Critical Evaluation of the Linkage Between Tick-Based Risk Measures and the Occurrence of Lyme Disease Cases. J Med Entomol. 2016;: pubmed
    ..considered the primary vector to humans in the eastern United States of the Lyme disease spirochete Borrelia burgdorferi sensu stricto. The abundance of infected host-seeking nymphs is commonly used to estimate the fundamental risk of ..
  76. Barstad B, Quarsten H, Tveitnes D, Noraas S, Ask I, Saeed M, et al. Direct Molecular Detection and Genotyping of Borrelia burgdorferi Sensu Lato in Cerebrospinal Fluid of Children with Lyme Neuroborreliosis. J Clin Microbiol. 2018;56: pubmed publisher
    The current diagnostic marker of Lyme neuroborreliosis (LNB), the Borrelia burgdorferisensu lato antibody index (AI) in the cerebrospinal fluid (CSF), has insufficient sensitivity in the early phase of LNB...
  77. Dolan M, Hojgaard A, Hoxmeier J, Replogle A, Respicio Kingry L, Sexton C, et al. Vector competence of the blacklegged tick, Ixodes scapularis, for the recently recognized Lyme borreliosis spirochete Candidatus Borrelia mayonii. Ticks Tick Borne Dis. 2016;7:665-669 pubmed publisher
    A novel species within the Borrelia burgdorferi sensu lato complex, provisionally named Borrelia mayonii, was recently found to be associated with Lyme borreliosis in the Upper Midwest of the United States. Moreover, B...
  78. Morgan A, Wang X. Structural mechanisms underlying sequence-dependent variations in GAG affinities of decorin binding protein A, a Borrelia burgdorferi adhesin. Biochem J. 2015;467:439-51 pubmed publisher
    Decorin-binding protein A (DBPA) is an important surface adhesin of the bacterium Borrelia burgdorferi, the causative agent of Lyme disease...
  79. di Meo N, Stinco G, Nan K, Pinzani C, Trevisan G. Parry-Romberg syndrome: a case with a possible association with Lyme disease. Acta Dermatovenerol Alp Pannonica Adriat. 2015;24:77-9 pubmed
    ..follow-up, the clinical disease progression was halted and the serological and microbiological tests for Borrelia burgdorferi sensu lato were negative...
  80. Clarke L, Ballweber L, Allen K, Little S, Lappin M. Prevalence of select vector-borne disease agents in owned dogs of Ghana. J S Afr Vet Assoc. 2014;85:996 pubmed publisher
    ..Sera were evaluated for Dirofilaria immitis antigen and antibodies against Borrelia burgdorferi, Anaplasma phagocytophilum and Ehrlichia canis...
  81. Castro L, Gabrielli S, Iori A, Cancrini G. Molecular detection of Rickettsia, Borrelia, and Babesia species in Ixodes ricinus sampled in northeastern, central, and insular areas of Italy. Exp Appl Acarol. 2015;66:443-52 pubmed publisher
    ..species of the spotted fever group of zoonotic concern and other zoonotic pathogens were found, such as Borrelia burgdorferi s.s., Borrelia afzelii, Borrelia garinii, and Babesia venatorum...
  82. Preyß Jägeler C, Muller E, Straubinger R, Hartmann K. Prevalence of antibodies against Borrelia burgdorferi, Anaplasma phagocytophilum, and Leptospira interrogans serovars in Bernese Mountain Dogs. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2016;44:77-85 pubmed publisher
    Bernese Mountain Dogs (BMD) have a higher prevalence of Borrelia burgdorferi sensu lato (Bbsl) antibodies than other breeds, but it is not known whether this is the case for other pathogens...
  83. Quarsten H, Grankvist A, Høyvoll L, Myre I, Skarpaas T, Kjelland V, et al. Candidatus Neoehrlichia mikurensis and Borrelia burgdorferi sensu lato detected in the blood of Norwegian patients with erythema migrans. Ticks Tick Borne Dis. 2017;8:715-720 pubmed publisher
    ..main aims of the study were to evaluate the contribution of several tick-borne bacterial agents, other than Borrelia burgdorferi sensu lato, to zoonotic diseases in Norway and to determine their clinical pictures...
  84. Wills M, Kirby A, Lloyd V. Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR. J Vis Exp. 2018;: pubmed publisher
    ..The primary etiological agent in North America is Borrelia burgdorferi sensu stricto. As geographic risk regions expand, it is prudent to support robust surveillance programs that can ..
  85. Zhou W, Brisson D. Potentially conflicting selective forces that shape the vls antigenic variation system in Borrelia burgdorferi. Infect Genet Evol. 2014;27:559-65 pubmed publisher
    ..conflicting selection pressures on antigenic variation systems using the vls antigenic variation system in Borrelia burgdorferi as a model system...
  86. Norte A, da Silva L, Tenreiro P, Felgueiras M, Araújo P, Lopes P, et al. Patterns of tick infestation and their Borrelia burgdorferi s.l. infection in wild birds in Portugal. Ticks Tick Borne Dis. 2015;6:743-50 pubmed publisher
    ..study was to assess tick infestation patterns in birds in Portugal and the prevalence of tick infection by Borrelia burgdorferi s.l. using PCR techniques...
  87. Bouquet J, Soloski M, Swei A, Cheadle C, Federman S, Billaud J, et al. Longitudinal Transcriptome Analysis Reveals a Sustained Differential Gene Expression Signature in Patients Treated for Acute Lyme Disease. MBio. 2016;7:e00100-16 pubmed publisher
    Lyme disease is a tick-borne illness caused by the bacterium Borrelia burgdorferi, and approximately 10 to 20% of patients report persistent symptoms lasting months to years despite appropriate treatment with antibiotics...
  88. Lacout A, Dacher V, El Hajjam M, Marcy P, Perronne C. Biofilms busters to improve the detection of Borrelia using PCR. Med Hypotheses. 2018;112:4-6 pubmed publisher
    Lyme disease is an affection caused by a spirochete infection called Borrelia Burgdorferi which may harbor a varied and misleading clinical symptomatology...
  89. Morris G, Berk M, Walder K, Maes M. The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability. Mol Neurobiol. 2016;53:2550-71 pubmed publisher
    ..strategies, including Parvoviruses, HHV6, variants of Epstein-Barr, Cytomegalovirus, Mycoplasma, and Borrelia burgdorferi. Other patients have a history of chronic fungal or other biotoxin exposure...
  90. Basile R, Rivera G, Del Rio L, de Bonis T, do Amaral G, Giangrecco E, et al. Anaphylactoid reaction caused by sodium ceftriaxone in two horses experimentally infected by Borrelia burgdorferi. BMC Vet Res. 2015;11:197 pubmed publisher
    ..Caused by a spirochete Borrelia burgdorferi, it can result in lameness, arthritis, carditis, dermatitis and neurological signs...
  91. Krzyzak L, Seitz C, Urbat A, Hutzler S, Ostalecki C, Gläsner J, et al. CD83 Modulates B Cell Activation and Germinal Center Responses. J Immunol. 2016;196:3581-94 pubmed publisher
    ..Furthermore, infection of mice with Borrelia burgdorferi revealed a defect in bacterial clearance of CD83 B-cKO mice with a shift toward a Th2 response, indicated ..
  92. Moen S, Edwards T, Dranow D, Clifton M, Sankaran B, Van Voorhis W, et al. Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms. Sci Rep. 2017;7:223 pubmed publisher
    ..Crystal structures were determined for a CysRS from Borrelia burgdorferi bound to AMP, GluRS from Borrelia burgdorferi and Burkholderia thailandensis bound to glutamic acid, a ..