Borrelia

Summary

Alias: Borrelia Swellengrebel 1907

Top Publications

  1. Jedlickova H, Durčanská V, Vasku V. Paraneoplastic Scleroderma: Are There Any Clues?. Acta Dermatovenerol Croat. 2016;24:78-80 pubmed
    ..She was treated with procaine penicillin for positive borrelia Immunoglobulin M (IgM) antibodies...
  2. Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y. Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library. Antibiotics (Basel). 2015;4:397-410 pubmed publisher
    ..In our previous study, we screened an FDA drug library and reported 27 top hits that showed high activity against Borrelia persisters...
  3. Wang H, Wu S, Jiang L, Xiao R, Li T, Mei L, et al. Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens. Parasit Vectors. 2018;11:442 pubmed publisher
    ..Epizootic hemorrhagic disease virus of deer, Coxiella burnetii, African swine fever virus, West Nile fever virus, Borrelia burgdorferi, vesicular stomatitis virus, Rift Valley fever virus, Ebola virus and Schmalenberg's disease virus, ..
  4. Scorza A, Lappin M. Prevalence of Selected Zoonotic and Vector-Borne Agents in Dogs and Cats on the Pine Ridge Reservation. Vet Sci. 2017;4: pubmed publisher
    ..Dog sera (n = 82) were tested for antibodies against T. gondii, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum and D. immitis antigen...
  5. Mali S, Mitchell M, Havis S, Bodunrin A, Rangel J, Olson G, et al. A Proteomic Signature of Dormancy in the Actinobacterium Micrococcus luteus. J Bacteriol. 2017;199: pubmed publisher
    ..i>Mycobacterium tuberculosis, Staphylococcus aureus, Treponema pallidum (syphilis), and Borrelia burgdorferi (Lyme disease), curtail metabolic activity to survive external stresses, including antibiotics...
  6. Bush L, Vazquez Pertejo M. Tick borne illness-Lyme disease. Dis Mon. 2018;64:195-212 pubmed publisher
    Lyme disease is the most commonly reported tick-borneillness in the United States. Thecausative spirochete, Borrelia burgdorferi is transmitted by 4 species of Ixodes tick species...
  7. Coleman J, Toledo A, Benach J. HtrA of Borrelia burgdorferi Leads to Decreased Swarm Motility and Decreased Production of Pyruvate. MBio. 2018;9: pubmed publisher
    i>Borrelia burgdorferi HtrA (HtrABb) is a serine protease that targets damaged or improperly folded proteins...
  8. Alfredsson M, Olafsson E, Eydal M, Unnsteinsdóttir E, Hansford K, Wint W, et al. Surveillance of Ixodes ricinus ticks (Acari: Ixodidae) in Iceland. Parasit Vectors. 2017;10:466 pubmed publisher
    Ixodes ricinus is a three-host tick, a principal vector of Borrelia burgdorferi (s.l.) and one of the main vectors of tick-borne encephalitis (TBE) virus. Iceland is located in the North Atlantic Ocean with subpolar oceanic climate...
  9. Gleim E, Garrison L, Vello M, Savage M, Lopez G, Berghaus R, et al. Factors associated with tick bites and pathogen prevalence in ticks parasitizing humans in Georgia, USA. Parasit Vectors. 2016;9:125 pubmed publisher
    ..for identification and polymerase chain reaction (PCR) testing for Francisella tularensis, Ehrlichia, Anaplasma, Borrelia, and Rickettsia spp...

More Information

Publications276 found, 100 shown here

  1. Figueredo L, Sales K, Deuster K, Pollmeier M, Otranto D, Dantas Torres F. Exposure to vector-borne pathogens in privately owned dogs living in different socioeconomic settings in Brazil. Vet Parasitol. 2017;243:18-23 pubmed publisher
    ..In particular, antibodies to Anaplasma spp., Borrelia burgdorferi sensu lato, and Ehrlichia spp...
  2. Sahay B, Bashant K, Nelson N, Patsey R, Gadila S, Boohaker R, et al. Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling. Infect Immun. 2018;86: pubmed publisher
    Host genotype influences the severity of murine Lyme borreliosis, caused by the spirochetal bacterium Borrelia burgdorferi C57BL/6 (B6) mice develop mild Lyme arthritis, whereas C3H/HeN (C3H) mice develop severe Lyme arthritis...
  3. Leulmi H, Aouadi A, Bitam I, Bessas A, Benakhla A, Raoult D, et al. Detection of Bartonella tamiae, Coxiella burnetii and rickettsiae in arthropods and tissues from wild and domestic animals in northeastern Algeria. Parasit Vectors. 2016;9:27 pubmed publisher
    ..Using real-time PCR, standard PCR and sequencing, the presence of Bartonella spp., Rickettsia spp., Borrelia spp...
  4. Lappin M. Update on flea and tick associated diseases of cats. Vet Parasitol. 2018;254:26-29 pubmed publisher
    ..Anaplasma phagocytophilum, Bartonella spp., Borrelia spp., Ehrlichia spp., hemoplasmas, and Rickettsia spp. infect cats and can be associated with clinical illness...
  5. Nelder M, Russell C, Sheehan N, Sander B, Moore S, Li Y, et al. Human pathogens associated with the blacklegged tick Ixodes scapularis: a systematic review. Parasit Vectors. 2016;9:265 pubmed publisher
    The blacklegged tick Ixodes scapularis transmits Borrelia burgdorferi (sensu stricto) in eastern North America; however, the agent of Lyme disease is not the sole pathogen harbored by the blacklegged tick...
  6. Gofton A, Oskam C, Lo N, Beninati T, Wei H, McCarl V, et al. Inhibition of the endosymbiont "Candidatus Midichloria mitochondrii" during 16S rRNA gene profiling reveals potential pathogens in Ixodes ticks from Australia. Parasit Vectors. 2015;8:345 pubmed publisher
    ..Ongoing controversy about the presence of Borrelia burgdorferi sensu lato (the aetiological agent of Lyme disease) in Australia increases the need to accurately ..
  7. Krause P, Fish D, Narasimhan S, Barbour A. Borrelia miyamotoi infection in nature and in humans. Clin Microbiol Infect. 2015;21:631-9 pubmed publisher
    b>Borrelia miyamotoi is a relapsing fever Borrelia group spirochete that is transmitted by the same hard-bodied (ixodid) tick species that transmit the agents of Lyme disease. It was discovered in 1994 in Ixodes persulcatus ticks in Japan...
  8. Suh G, Ahn K, Ahn J, Kim H, Leutenegger C, Shin S. Serological and molecular prevalence of canine vector-borne diseases (CVBDs) in Korea. Parasit Vectors. 2017;10:146 pubmed publisher
    ..2%), followed by Anaplasma phagocytophilum (15.6%), Ehrlichia canis (4.7%) whereas Borrelia burgdorferi showed the lowest prevalence (1.1%)...
  9. Hutchinson M, Strohecker M, Simmons T, Kyle A, Helwig M. Prevalence Rates of Borrelia burgdorferi (Spirochaetales: Spirochaetaceae), Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae), and Babesia microti (Piroplasmida: Babesiidae) in Host-Seeking Ixodes scapularis (Acari: Ixodidae) from Pennsylvan. J Med Entomol. 2015;52:693-8 pubmed publisher
    The etiological agents responsible for Lyme disease (Borrelia burgdorferi), human granulocytic anaplasmosis (Anaplasma phagocytophilum), and babesiosis (Babesia microti) are primarily transmitted by the blacklegged tick, Ixodes scapularis ..
  10. Obolo Mvoulouga P, Oleaga A, Manzano Román R, Pérez Sánchez R. Evaluation of the protective efficacy of Ornithodoros moubata midgut membrane antigens selected using omics and in silico prediction algorithms. Ticks Tick Borne Dis. 2018;9:1158-1172 pubmed publisher
    ..tick Ornithodoros moubata transmits two important pathogens, the African swine fever virus and the spirochete Borrelia duttoni, the cause of human relapsing fever...
  11. Zhang Y, Wei Z, Li J, Liu P. Molecular pathogenesis of lymphomas of mucosa-associated lymphoid tissue--from (auto)antigen driven selection to the activation of NF-κB signaling. Sci China Life Sci. 2015;58:1246-55 pubmed publisher
    ..The infection of certain pathogens, such as Helicobacter pylori, Chlamydophila psittaci, Borrelia burgdorferi, hepatitis C virus, or certain autoantigens cause these sites to generate a germinal center called ..
  12. Pantchev N, Pluta S, Huisinga E, Nather S, Scheufelen M, Vrhovec M, et al. Tick-borne Diseases (Borreliosis, Anaplasmosis, Babesiosis) in German and Austrian Dogs: Status quo and Review of Distribution, Transmission, Clinical Findings, Diagnostics and Prophylaxis. Parasitol Res. 2015;114 Suppl 1:S19-54 pubmed publisher
    ..The widespread European tick species Ixodes ricinus represents an important vector for spirochaetes of the Borrelia burgdorferi sensu lato group and Rickettsiales such as Anaplasma phagocytophilum...
  13. Vial L, Ducheyne E, Filatov S, Gerilovych A, Mcvey D, Sindryakova I, et al. Spatial multi-criteria decision analysis for modelling suitable habitats of Ornithodoros soft ticks in the Western Palearctic region. Vet Parasitol. 2018;249:2-16 pubmed publisher
    ..they can also transmit pathogens, including African Swine Fever Virus (ASFV) affecting domestic and wild suids or Borrelia bacteria causing tick-borne relapsing fever (TBRF) in humans...
  14. Urbanová V, Hajdusek O, Sima R, Franta Z, Honig Mondekova H, Grunclová L, et al. IrC2/Bf - A yeast and Borrelia responsive component of the complement system from the hard tick Ixodes ricinus. Dev Comp Immunol. 2018;79:86-94 pubmed publisher
    ..up-regulated in response to the intra-hemocoelic injection of the yeast Candida albicans and all tested Borrelia sp. strains (B. burgdorferi NE5264, B. burgdorferi CB26, B. garinii MSLB, B...
  15. Little S, Barrett A, Nagamori Y, Herrin B, Normile D, Heaney K, et al. Ticks from cats in the United States: Patterns of infestation and infection with pathogens. Vet Parasitol. 2018;257:15-20 pubmed publisher
    ..Assay of ticks removed from cats revealed I. scapularis were infected with Borrelia burgdorferi (25.7%) and Anaplasma phagocytophilum (4.4%); A...
  16. Buczek A, Ciura D, Bartosik K, ZajÄ…c Z, Kulisz J. Threat of attacks of Ixodes ricinus ticks (Ixodida: Ixodidae) and Lyme borreliosis within urban heat islands in south-western Poland. Parasit Vectors. 2014;7:562 pubmed publisher
    ..of borreliosis risk in the region was determined on the basis of the results of research on the prevalence of Borrelia burgdorferi s.l. in ticks and reports from sanitary-epidemiological stations. In total, 2061 I...
  17. Yu P, Niu Q, Liu Z, Yang J, Chen Z, Guan G, et al. Molecular epidemiological surveillance to assess emergence and re-emergence of tick-borne infections in tick samples from China evaluated by nested PCRs. Acta Trop. 2016;158:181-188 pubmed publisher
    ..different locations in eight provinces of China and subjected to screening for tick-borne pathogens, including Borrelia burgdorferi sensu lato, Ehrlichia spp., Rickettsia spp., Babesia/Theileria spp...
  18. Da Rold G, Ravagnan S, Soppelsa F, Porcellato E, Soppelsa M, Obber F, et al. Ticks are more suitable than red foxes for monitoring zoonotic tick-borne pathogens in northeastern Italy. Parasit Vectors. 2018;11:137 pubmed publisher
    ..adults (264), pooled larvae (n?=?330) and nymphs (n?=?1984) were screened for tick-borne encephalitis virus, Borrelia burgdorferi (s.l.), Rickettsia spp., Babesia spp...
  19. Detmer S, Bouljihad M, Hayden D, Schefers J, Armien A, Wünschmann A. Fatal pyogranulomatous myocarditis in 10 Boxer puppies. J Vet Diagn Invest. 2016;28:144-9 pubmed publisher
    ..All dogs were positive for Borrelia burgdorferi on immunohistochemistry (IHC)...
  20. Lindblom A, Wallménius K, Sjöwall J, Fryland L, Wilhelmsson P, Lindgren P, et al. Prevalence of Rickettsia spp. in Ticks and Serological and Clinical Outcomes in Tick-Bitten Individuals in Sweden and on the Åland Islands. PLoS ONE. 2016;11:e0166653 pubmed publisher
    Tick-transmitted diseases are an emerging health problem, and the hard tick Ixodes ricinus is the main vector for Borrelia spp., tick-borne encephalitis virus and most of the spotted fever Rickettsiae in Europe...
  21. Krawczyk A, van Leeuwen A, Jacobs Reitsma W, Wijnands L, Bouw E, Jahfari S, et al. Presence of zoonotic agents in engorged ticks and hedgehog faeces from Erinaceus europaeus in (sub) urban areas. Parasit Vectors. 2015;8:210 pubmed publisher
    ..Ticks were screened individually for presence of Borrelia burgdorferi sensu lato, B...
  22. Mayne P, Song S, Shao R, Burke J, Wang Y, Roberts T. Evidence for Ixodes holocyclus (Acarina: Ixodidae) as a vector for human lyme Borreliosis infection in Australia. J Insect Sci. 2014;14:271 pubmed publisher
    ..Borreliosis otherwise known as Lyme disease is an emerging infectious disease in humans in Australia. Borrelia burgdorferi sensu stricto (Spirochaetales: Spirochaetaceae) and sensu lato are closely related spirochetal ..
  23. Płusa T. [History of the study, epidemiology of the disease and characterization of Borrelia burgdorferi infection]. Pol Merkur Lekarski. 2017;43:99-103 pubmed
    ..However, a number of lipoproteins have been defined and some of them may be factors contributing to the innate immune system...
  24. Starkey L, Newton K, Brunker J, Crowdis K, Edourad E, Meneus P, et al. Prevalence of vector-borne pathogens in dogs from Haiti. Vet Parasitol. 2016;224:7-12 pubmed publisher
    ..9%), antibodies to Anaplasma spp. in 37 (17.6%), and antigen of Dirofilaria immitis in 55 (26.2%); antibodies to Borrelia burgdorferi were not detected in any sample...
  25. Sonnleitner S, Margos G, Wex F, Simeoni J, Zelger R, Schmutzhard E, et al. Human seroprevalence against Borrelia burgdorferi sensu lato in two comparable regions of the eastern Alps is not correlated to vector infection rates. Ticks Tick Borne Dis. 2015;6:221-7 pubmed publisher
    ..In the Tyrols, the continental divide delimitates areas with high seroprevalences of IgG antibodies against Borrelia burgdorferi sensu lato in the North (7.2%) from areas with low seroprevalences in the South (1.5%)...
  26. Kuchynka P, Palecek T, Havranek S, Vitkova I, Nemecek E, Trckova R, et al. Recent-onset dilated cardiomyopathy associated with Borrelia burgdorferi infection. Herz. 2015;40:892-7 pubmed publisher
    ..a causal link between Lyme disease and dilated cardiomyopathy (DCM) by demonstrating the presence of the Borrelia burgdorferi (Bb) genome in the myocardium of patients with recent-onset DCM...
  27. Ouyang Z, Zhou J. BadR (BB0693) controls growth phase-dependent induction of rpoS and bosR in Borrelia burgdorferi via recognizing TAAAATAT motifs. Mol Microbiol. 2015;98:1147-67 pubmed publisher
    In Borrelia burgdorferi (Bb), the alternative sigma factor RpoS plays a central role during Bb's adaptation to ticks and mammals...
  28. Khasnatinov M, Liapunov A, Manzarova E, Kulakova N, Petrova I, Danchinova G. The diversity and prevalence of hard ticks attacking human hosts in Eastern Siberia (Russian Federation) with first description of invasion of non-endemic tick species. Parasitol Res. 2016;115:501-10 pubmed publisher
    Hard ticks are the vectors of many pathogens including tick-borne encephalitis virus and the Lyme disease agent Borrelia burgdorferi sensu lato...
  29. Ebani V, Bertelloni F, Mani P. Molecular survey on zoonotic tick-borne bacteria and chlamydiae in feral pigeons (Columba livia domestica). Asian Pac J Trop Med. 2016;9:324-327 pubmed publisher
    ..b>Borrelia burgdorferi sensu lato, Coxiella burnetii, Rickettsia spp., and Chlamydophila spp. Twenty (23...
  30. Henningsson A, Gyllemark P, Lager M, Skogman B, Tjernberg I. Evaluation of two assays for CXCL13 analysis in cerebrospinal fluid for laboratory diagnosis of Lyme neuroborreliosis. APMIS. 2016;124:985-990 pubmed publisher
    ..We consider CSF-CXCL13 analysis a useful diagnostic tool, in addition to Borrelia-specific AI, in laboratory diagnostics of LNB.
  31. Baker C, McCall J, McCall S, Drag M, Mitchell E, Chester S, et al. Ability of an oral formulation of afoxolaner to protect dogs from Borrelia burgdorferi infection transmitted by wild Ixodes scapularis ticks. Comp Immunol Microbiol Infect Dis. 2016;49:65-69 pubmed publisher
    ..would prevent the transmission of Borrelia burgdorferi to dogs by wild caught Ixodes scapularis ticks...
  32. Popitsch N, Bilusic I, Rescheneder P, Schroeder R, Lybecker M. Temperature-dependent sRNA transcriptome of the Lyme disease spirochete. BMC Genomics. 2017;18:28 pubmed publisher
    Transmission of Borrelia burgdorferi from its tick vector to a vertebrate host requires extensive reprogramming of gene expression...
  33. Casjens S, Gilcrease E, Vujadinovic M, Mongodin E, Luft B, Schutzer S, et al. Plasmid diversity and phylogenetic consistency in the Lyme disease agent Borrelia burgdorferi. BMC Genomics. 2017;18:165 pubmed publisher
    Bacteria from the genus Borrelia are known to harbor numerous linear and circular plasmids...
  34. Dunaj J, Moniuszko Malinowska A, Swiecicka I, Andersson M, Czupryna P, Rutkowski K, et al. Tick-borne infections and co-infections in patients with non-specific symptoms in Poland. Adv Med Sci. 2018;63:167-172 pubmed publisher
    ..47.5% were infected with at least one tick-borne pathogen. Borrelia burgdorferi sensu lato infection was confirmed with ELISA, Western blot in serum and/or (PCR (fla gene) in whole ..
  35. Welc Faleciak R, Kowalska J, Bednarska M, Szatan M, Pawełczyk A. Molecular identification of tick-borne pathogens in asymptomatic individuals with human immunodeficiency virus type 1 (HIV-1) infection: a retrospective study. BMC Infect Dis. 2018;18:227 pubmed publisher
    ..with Anaplasma phagocytophilum - the agent of human granulocytic anaplasmosis (HGA) and in the other with Borrelia garinii. Our study revealed the first case of HIV positive patient infected with A. phagocytophilum...
  36. Verhey T, Castellanos M, Chaconas G. Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair. Cell Rep. 2018;23:2595-2605 pubmed publisher
    The Lyme disease spirochete, Borrelia burgdorferi, uses antigenic variation as a strategy to evade the host's acquired immune response...
  37. Lommano E, Dvořák C, Vallotton L, Jenni L, Gern L. Tick-borne pathogens in ticks collected from breeding and migratory birds in Switzerland. Ticks Tick Borne Dis. 2014;5:871-82 pubmed publisher
    ..Each tick was analysed individually for the presence of Borrelia spp., Rickettsia spp., Anaplasma phagocytophilum and tick-borne encephalitis virus (TBEV). Altogether, 11...
  38. Stone B, Russart N, Gaultney R, Floden A, Vaughan J, Brissette C. The Western progression of lyme disease: infectious and Nonclonal Borrelia burgdorferi Sensu Lato populations in Grand Forks County, North Dakota. Appl Environ Microbiol. 2015;81:48-58 pubmed publisher
    Scant attention has been paid to Lyme disease, Borrelia burgdorferi, Ixodes scapularis, or reservoirs in eastern North Dakota despite the fact that it borders high-risk counties in Minnesota. Recent reports of B. burgdorferi and I...
  39. Middelveen M, Bandoski C, Burke J, Sapi E, Filush K, Wang Y, et al. Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia burgdorferi in Morgellons disease patients. BMC Dermatol. 2015;15:1 pubmed publisher
    ..Strength of evidence based on other testing varied among patients. Spirochetes identified as Borrelia strains by polymerase chain reaction (PCR) and/or in-situ DNA hybridization were detected in 24/25 of our study ..
  40. Halperin J. Nervous system Lyme disease, chronic Lyme disease, and none of the above. Acta Neurol Belg. 2016;116:1-6 pubmed publisher
    Lyme borreliosis, infection with the tick-borne spirochete Borrelia burgdorferi sensu lato, causes nervous system involvement in 10-15 % of identified infected individuals...
  41. Elbir H, FotsoFotso A, Diatta G, Trape J, Arnathau C, Renaud F, et al. Ubiquitous bacteria Borrelia crocidurae in Western African ticks Ornithodoros sonrai. Parasit Vectors. 2015;8:477 pubmed publisher
    In West Africa, tick-borne relapsing fever is a neglected arthropod-borne infection caused by Borrelia crocidurae transmitted by the argasid tick Ornithodoros sonrai...
  42. Tilly K, Bestor A, Rosa P. Functional Equivalence of OspA and OspB, but Not OspC, in Tick Colonization by Borrelia burgdorferi. Infect Immun. 2016;84:1565-1573 pubmed publisher
    b>Borrelia burgdorferi, a Lyme disease agent, makes different major outer surface lipoproteins at different stages of its mouse-tick infectious cycle...
  43. Moon K, Hobbs G, Motaleb M. Borrelia burgdorferi CheD Promotes Various Functions in Chemotaxis and the Pathogenic Life Cycle of the Spirochete. Infect Immun. 2016;84:1743-1752 pubmed publisher
    b>Borrelia burgdorferi possesses a sophisticated chemotaxis signaling system; however, the roles of the majority of the chemotaxis proteins in the infectious life cycle have not yet been demonstrated...
  44. States S, Huang C, Davis S, Tufts D, Diuk Wasser M. Co-feeding transmission facilitates strain coexistence in Borrelia burgdorferi, the Lyme disease agent. Epidemics. 2017;19:33-42 pubmed publisher
    ..In a laboratory study, we demonstrated that co-feeding transmission can occur for a rapidly-cleared strain of Borrelia burgdorferi, the Lyme disease agent, between two stages of the tick vector Ixodes scapularis while feeding on ..
  45. Thakur M, Sharma K, Chao K, Smith A, Herzberg O, Pal U. A protein-protein interaction dictates Borrelial infectivity. Sci Rep. 2017;7:2932 pubmed publisher
    Two Borrelia burgdorferi interacting proteins, BB0238 and BB0323, play distinct roles in pathogen biology and infectivity although a significance of their interaction remained enigmatic...
  46. van Gorkom T, Kremer K, Voet W, Notermans D, Vlaminckx B, Sankatsing S, et al. Disagreement between the results from three commercial tests for the detection of Borrelia-specific serum antibodies in the Netherlands associated with antibiotic treatment for Lyme borreliosis: a retrospective study. Eur J Clin Microbiol Infect Dis. 2017;36:2137-2146 pubmed publisher
    ..characteristics of two enzyme-linked immunosorbent assays (ELISAs) and an immunoblot for the detection of Borrelia-specific serum antibodies using different test strategies in individuals with and without antibiotic treatment ..
  47. Molins C, Ashton L, Wormser G, Andre B, Hess A, Delorey M, et al. Metabolic differentiation of early Lyme disease from southern tick-associated rash illness (STARI). Sci Transl Med. 2017;9: pubmed publisher
    Lyme disease, the most commonly reported vector-borne disease in the United States, results from infection with Borrelia burgdorferi...
  48. Zhao H, Liu A, Cui Y, Liang Z, Li B, Bao F. Borrelia burgdorferi basic membrane protein A could induce chemokine production in murine microglia cell line BV2. Microb Pathog. 2017;111:174-181 pubmed publisher
    Lyme neuroborreliosis is a nervous system infectious disease caused by Borrelia burgdorferi (B. burgdorferi). It has been demonstrated that cytokines induced by B. burgdorferi are related to Lyme neuroborreliosis...
  49. Turk S, Williams C, Marques A. Xenodiagnosis Using Ixodes scapularis Larval Ticks in Humans. Methods Mol Biol. 2018;1690:337-346 pubmed publisher
    ..long been used by entomologists in Lyme disease research to provide evidence of the host's infectious status with Borrelia burgdorferi...
  50. Eguchi K, Tsuzaka K, Yabe I, Sasaki H. [A case of Lyme neuroborreliosis without erythema migrans]. Rinsho Shinkeigaku. 2018;58:124-126 pubmed publisher
    ..Western blot analysis for serum IgM and IgG antibodies against Borrelia were positive. We diagnosed Lyme borreliosis...
  51. Mavin S, Evans R, Cornulier T, Bowman A. The development of an IgG avidity Western blot with potential to differentiate patients with active Lyme borreliosis from those with past infection. J Microbiol Methods. 2018;146:71-76 pubmed publisher
    Current serological methods cannot distinguish active from past infection with Borrelia burgdorferi sensu lato...
  52. Nader J, Król N, Pfeffer M, Ohlendorf V, Marklewitz M, Drosten C, et al. The diversity of tick-borne bacteria and parasites in ticks collected from the Strandja Nature Park in south-eastern Bulgaria. Parasit Vectors. 2018;11:165 pubmed publisher
    ..b>Borrelia burgdorferi (s.l.), Rickettsia spp...
  53. Roome A, Spathis R, Hill L, Darcy J, Garruto R. Lyme Disease Transmission Risk: Seasonal Variation in the Built Environment. Healthcare (Basel). 2018;6: pubmed publisher
    Seasonal variation in spatial distribution and pathogen prevalence of Borrelia burgdorferi in blacklegged ticks (Ixodes scapularis) influences human population risk of Lyme disease in peri-urban built environments...
  54. Mlynarcik P, Pulzova L, Bencúrová E, Kovac A, Dominguez M, Hreško S, et al. Deciphering the interface between a CD40 receptor and borrelial ligand OspA. Microbiol Res. 2015;170:51-60 pubmed publisher
    ..Neuroinvasion is largely relied on successful translocation of Borrelia across the blood-brain barrier...
  55. Stromdahl E, Hamer S, Jenkins S, Sloan L, Williamson P, Foster E, et al. Comparison of phenology and pathogen prevalence, including infection with the Ehrlichia muris-like (EML) agent, of Ixodes scapularis removed from soldiers in the midwestern and the northeastern United States over a 15 year period (1997-2012). Parasit Vectors. 2014;7:553 pubmed publisher
    ..scapularis from the three installations and tested them for Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi and the Ehrlichia muris-like (EML) agent using PCR; pathogen presence was confirmed via sequencing or ..
  56. Bonnet S, Choumet V, Masseglia S, Cote M, Ferquel E, Lilin T, et al. Infection of Siberian chipmunks (Tamias sibiricus barberi) with Borrelia sp. reveals a low reservoir competence under experimental conditions. Ticks Tick Borne Dis. 2015;6:393-400 pubmed publisher
    ..chipmunk (Tamias sibiricus barberi) recently introduced into Europe, for the multi-host tick-borne bacteria, Borrelia burgdorferi sl, the agent of Lyme borreliosis. T...
  57. Hönig V, Svec P, Halas P, Vavrušková Z, Tykalová H, Kilian P, et al. Ticks and tick-borne pathogens in South Bohemia (Czech Republic)--Spatial variability in Ixodes ricinus abundance, Borrelia burgdorferi and tick-borne encephalitis virus prevalence. Ticks Tick Borne Dis. 2015;6:559-67 pubmed publisher
    Spatial distribution of Ixodes ricinus tick host-seeking activity, as well as prevalence of Borrelia burgdorferi sensu lato and tick-borne encephalitis virus (TBEV) were studied in the TBE endemic area of South Bohemia (Czech Republic)...
  58. Cerar T, Korva M, Avšič Županc T, Ružić Sabljić E. Detection, identification and genotyping of Borrellia spp. in rodents in Slovenia by PCR and culture. BMC Vet Res. 2015;11:188 pubmed publisher
    b>Borrelia burgdorferi sensu lato, the agent of Lyme borreliosis, is mainly maintained in natural foci through the transmission cycles of competent tick vectors (Ixodes sp.) and a vertebrate reservoir...
  59. Esteve Gassent M, Smith T, Small C, Thomas D, Seshu J. Absence of sodA Increases the Levels of Oxidation of Key Metabolic Determinants of Borrelia burgdorferi. PLoS ONE. 2015;10:e0136707 pubmed publisher
    b>Borrelia burgdorferi, the causative agent of Lyme disease, alters its gene expression in response to environmental signals unique to its tick vector or vertebrate hosts. B...
  60. Fotso Fotso A, Angelakis E, Mouffok N, Drancourt M, Raoult D. Blood-Borne Candidatus Borrelia algerica in a Patient with Prolonged Fever in Oran, Algeria. Am J Trop Med Hyg. 2015;93:1070-3 pubmed publisher
    To improve the knowledge base of Borrelia in north Africa, we tested 257 blood samples collected from febrile patients in Oran, Algeria, between January and December 2012 for Borrelia species using flagellin gene polymerase chain reaction ..
  61. Oleaga A, Obolo Mvoulouga P, Manzano Román R, Pérez Sánchez R. Midgut proteome of an argasid tick, Ornithodoros erraticus: a comparison between unfed and engorged females. Parasit Vectors. 2015;8:525 pubmed publisher
    The argasid tick Ornithodoros erraticus is the vector of African swine fever virus and of several Borrelia species that cause human relapsing fever in the Iberian Peninsula...
  62. Henrich E, Ma Y, Engels I, Münch D, Otten C, Schneider T, et al. Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway. J Biol Chem. 2016;291:2535-46 pubmed publisher
    ..MraY homologues originating from Bordetella pertussis, Helicobacter pylori, Chlamydia pneumoniae, Borrelia burgdorferi, and Escherichia coli as well as Bacillus subtilis were co-translationally solubilized using either ..
  63. Maraspin V, Nahtigal Klevišar M, Ruzic Sabljic E, Lusa L, Strle F. Borrelial Lymphocytoma in Adult Patients. Clin Infect Dis. 2016;63:914-21 pubmed publisher
    ..3%) who had not received antibiotics before skin biopsy. Of 13 typed Borrelia strains, 11 were B. afzelii, 1 was B. garinii, and 1 was B...
  64. Colomba C, Scarlata F, Di Carlo P, Giammanco A, Fasciana T, Trizzino M, et al. Fourth case of louse-borne relapsing fever in Young Migrant, Sicily, Italy, December 2015. Mini Review Article. Public Health. 2016;139:22-26 pubmed publisher
    ..LBRF by Borrelia recurrentis should be considered among the clinical hypotheses in migrants presenting with fever, headache, ..
  65. Macdonald E, Vestrheim D, White R, Konsmo K, Lange H, Aase A, et al. Are the current notification criteria for Lyme borreliosis in Norway suitable? Results of an evaluation of Lyme borreliosis surveillance in Norway, 1995-2013. BMC Public Health. 2016;16:729 pubmed publisher
    ..The current notification criteria include a combination of clinical and laboratory results for borrelia infection (excluding Erythema migrans) but there are indications that these criteria are not followed ..
  66. Mason L, Wagemakers A, Van T Veer C, Oei A, van der Pot W, Ahmed K, et al. Borrelia burgdorferi Induces TLR2-Mediated Migration of Activated Dendritic Cells in an Ex Vivo Human Skin Model. PLoS ONE. 2016;11:e0164040 pubmed publisher
    b>Borrelia burgdorferi is transmitted into the skin of the host where it encounters and interacts with two dendritic cell (DC) subsets; Langerhans cells (LCs) and dermal DCs (DDCs)...
  67. Zajac V, Pinkas J, Wojcik Fatla A, Dutkiewicz J, Owoc A, Bojar I. Prevalence of serological response to Borrelia burgdorferi in farmers from eastern and central Poland. Eur J Clin Microbiol Infect Dis. 2017;36:437-446 pubmed publisher
    Lyme borreliosis (Lyme disease) caused by the Borrelia burgdorferi sensu lato spirochete is the most common tick-borne infection manifested by a wide spectrum of clinical symptoms...
  68. Oosting M, Kerstholt M, Ter Horst R, Li Y, Deelen P, Smeekens S, et al. Functional and Genomic Architecture of Borrelia burgdorferi-Induced Cytokine Responses in Humans. Cell Host Microbe. 2016;20:822-833 pubmed publisher
    ..outcome of Lyme disease, the factors influencing cytokine production during infection with the causal pathogen Borrelia burgdorferi remain poorly understood...
  69. Norek A, Janda L. Epitope mapping of Borrelia burgdorferi OspC protein in homodimeric fold. Protein Sci. 2017;26:796-806 pubmed publisher
    ..The third mAb (2D1) recognises highly conserved discontinuous epitope close to the ligand binding domain 1. ..
  70. Jacquet M, Genné D, Belli A, Maluenda E, Sarr A, Voordouw M. The abundance of the Lyme disease pathogen Borrelia afzelii declines over time in the tick vector Ixodes ricinus. Parasit Vectors. 2017;10:257 pubmed publisher
    ..Tick-borne spirochete bacteria of the Borrelia burgdorferi (sensu lato) species complex cause Lyme borreliosis in humans and spend long periods of time (>..
  71. Drewes S, Strakova P, Drexler J, Jacob J, Ulrich R. Assessing the Diversity of Rodent-Borne Viruses: Exploring of High-Throughput Sequencing and Classical Amplification/Sequencing Approaches. Adv Virus Res. 2017;99:61-108 pubmed publisher
    ..In addition, rodents are reservoirs for vector-borne pathogens, such as tick-borne encephalitis virus and Borrelia spp., and may carry human pathogenic agents, but likely are not involved in their transmission to human...
  72. Patton S, Phillips B. CE: Lyme Disease: Diagnosis, Treatment, and Prevention. Am J Nurs. 2018;118:38-45 pubmed publisher
    ..both increasing numbers of Lyme disease cases and geographic expansion of areas where the causative spirochete, Borrelia burgdorferi, can be found...
  73. Bernard Q, Smith A, Yang X, Koci J, Foor S, Cramer S, et al. Plasticity in early immune evasion strategies of a bacterial pathogen. Proc Natl Acad Sci U S A. 2018;115:E3788-E3797 pubmed publisher
    i>Borrelia burgdorferi is one of the few extracellular pathogens capable of establishing persistent infection in mammals. The mechanisms that sustain long-term survival of this bacterium are largely unknown...
  74. Mechai S, Margos G, Feil E, Lindsay L, Michel P, Kotchi S, et al. Evidence for an effect of landscape connectivity on Borrelia burgdorferi sensu stricto dispersion in a zone of range expansion. Ticks Tick Borne Dis. 2018;9:1407-1415 pubmed publisher
    In North America, different strains of the Lyme disease-causing bacterium Borrelia burgdorferi sensu stricto cluster into phylogenetic groups that are associated with different levels of pathogenicity and, for some, specific rodent ..
  75. Ebani V, Bertelloni F, Turchi B, Filogari D, Cerri D. Molecular survey of tick-borne pathogens in Ixodid ticks collected from hunted wild animals in Tuscany, Italy. Asian Pac J Trop Med. 2015;8:714-7 pubmed publisher
    ..PCR was executed on DNA extracted from 77 tick pools to detect Anaplasma phagocytophilum, Bartonella spp., Borrelia burgdorferi sensu lato, Coxiella burnetii and Rickettsia spp. A total of 432 ticks were collected: 30 (6...
  76. Khatchikian C, Nadelman R, Nowakowski J, Schwartz I, Levy M, Brisson D, et al. Public health impact of strain specific immunity to Borrelia burgdorferi. BMC Infect Dis. 2015;15:472 pubmed publisher
    Lyme disease, caused by Borrelia burgdorferi, is the most common tick-borne infection in the United States. Although humans can be infected by at least 16 different strains of B...
  77. Drenckhahn A, Spors B, Knierim E. Acute isolated partial oculomotor nerve palsy due to Lyme neuroborreliosis in a 5 year old girl. Eur J Paediatr Neurol. 2016;20:977-979 pubmed publisher
    ..Lyme neuroborreliosis is a frequent cause of facial nerve palsy in children, isolated oculomotor nerve palsy due to Borrelia-associated nervous system infection however is rarely seen...
  78. Huang W, Ojaimi C, Fallon J, Travisany D, Maass A, Ivanova L, et al. Genome Sequence of Borrelia chilensis VA1, a South American Member of the Lyme Borreliosis Group. Genome Announc. 2015;3: pubmed publisher
    b>Borrelia chilensis strain VA1 is a recently described South American member of the Borrelia burgdorferi sensu lato complex from Chile...
  79. Gryczyńska A, Welc Faleciak R. Long-term study of the prevalence of Borrelia burgdorferi s.l. infection in ticks (Ixodes ricinus) feeding on blackbirds (Turdus merula) in NE Poland. Exp Appl Acarol. 2016;70:381-394 pubmed
    Seeking evidence to confirm that blackbirds (Turdus merula) may be involved in environmental maintenance of Borrelia burgdorferi s.l...
  80. Kuo C, Lin Y, Yao C, Shih H, Chung L, Liao H, et al. Tick-borne pathogens in ticks collected from birds in Taiwan. Parasit Vectors. 2017;10:587 pubmed publisher
    ..information and were screened for potential tick-borne pathogens, including the genera Anaplasma, Babesia, Borrelia, Ehrlichia and Rickettsia...
  81. Bauer W, Luthra A, Zhu G, Radolf J, Malkowski M, Caimano M. Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding. J Struct Biol. 2015;192:48-58 pubmed publisher
    ..The Hk1/Rrp1 two-component system (TCS) in Borrelia burgdorferi consists of a hybrid histidine kinase and a response regulator with diguanylate cyclase activity, ..
  82. Klaus C, Gethmann J, Hoffmann B, Ziegler U, Heller M, Beer M. Tick infestation in birds and prevalence of pathogens in ticks collected from different places in Germany. Parasitol Res. 2016;115:2729-40 pubmed publisher
    ..with real-time RT-PCR, Flaviviruses, Simbuviruses and Lyssaviruses with broad-range standard RT-PCR-assays, and Borrelia spp. with a Pan-Borrelia real-time PCR. Interestingly, no viral pathogens could be detected, but Borrelia spp...
  83. Saracho Bottero M, Sebastian P, Carvalho L, Claps L, Mastropaolo M, Mangold A, et al. Presence of Borrelia in different populations of Ixodes pararicinus from northwestern Argentina. Ticks Tick Borne Dis. 2017;8:488-493 pubmed publisher
    This work was performed to evaluate the presence of Borrelia in different populations of Ixodes pararicinus from northwestern Argentina (Jujuy, Salta and Tucumán provinces). Questing adults and nymphs of I...
  84. Neelakanta G, Sultana H, Sonenshine D, Andersen J. Identification and characterization of a histamine-binding lipocalin-like molecule from the relapsing fever tick Ornithodoros turicata. Insect Mol Biol. 2017;: pubmed publisher
    ..as otlip, from the soft ticks Ornithodoros turicata, the vector for the relapsing fever causing spirochete Borrelia turicatae...
  85. Diallo M, Diongue K, Seck M, Ndiaye M, Diallo I, Diedhiou Y, et al. Quality control of malaria microscopy reveals misdiagnosed non-falciparum species and other microscopically detectable pathogens in Senegal. Ann Clin Microbiol Antimicrob. 2018;17:8 pubmed publisher
    ..Only one major error was recorded (HFP). Six laboratories recorded LFN results: Borrelia, P. ovale, and low parasite densities (95 and 155 p/?l) were missed. Two P...
  86. Molloy P, Weeks K, Todd B, Wormser G. Seroreactivity to the C6 Peptide in Borrelia Miyamotoi Infections Occurring in the Northeastern United States. Clin Infect Dis. 2017;: pubmed publisher
    There are no Food and Drug Administration (FDA) approved diagnostic tests for Borrelia miyamotoi infection, an emerging tick-borne illness in the United States...
  87. Skogman B, Sjöwall J, Lindgren P. The NeBoP score - a clinical prediction test for evaluation of children with Lyme Neuroborreliosis in Europe. BMC Pediatr. 2015;15:214 pubmed publisher
    ..neuroborreliosis (LNB) in Europe is based on clinical symptoms and laboratory data, such as pleocytosis and anti-Borrelia antibodies in serum and CSF according to guidelines...
  88. Lieske D, Lloyd V. Combining public participatory surveillance and occupancy modelling to predict the distributional response of Ixodes scapularis to climate change. Ticks Tick Borne Dis. 2018;9:695-706 pubmed publisher
    Ixodes scapularis, a known vector of Borrelia burgdorferi sensu stricto (Bbss), is undergoing range expansion in many parts of Canada. The province of New Brunswick, which borders jurisdictions with established populations of I...
  89. Schvartz G, Epp T, Burgess H, Chilton N, Lohmann K. Comparison between available serologic tests for detecting antibodies against Anaplasma phagocytophilum and Borrelia burgdorferi in horses in Canada. J Vet Diagn Invest. 2015;27:540-6 pubmed publisher
    ..agreement between available serologic tests for the detection of antibodies against Anaplasma phagocytophilum and Borrelia burgdorferi, 50 serum samples from horses of unknown clinical status and at low risk for infection were tested...
  90. Ramesh G, Martinez A, Martin D, Philipp M. Effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in glial and neuronal cells of the central nervous system. J Neuroinflammation. 2017;14:28 pubmed publisher
    Lyme neuroborreliosis (LNB), caused by the spirochete Borrelia burgdorferi (Bb), affects both the central and peripheral nervous systems...
  91. Williams S, Stafford K, Molaei G, Linske M. Integrated Control of Nymphal Ixodes scapularis: Effectiveness of White-Tailed Deer Reduction, the Entomopathogenic Fungus Metarhizium anisopliae, and Fipronil-Based Rodent Bait Boxes. Vector Borne Zoonotic Dis. 2018;18:55-64 pubmed publisher
    ..had the most impact of any treatment combination; questing nymphs were reduced 78-95% within each year and Borrelia burgdorferi-infected questing nymphal I...
  92. Egizi A, Roegner V, Faraji A, Healy S, Schulze T, Jordan R. A historical snapshot of Ixodes scapularis-borne pathogens in New Jersey ticks reflects a changing disease landscape. Ticks Tick Borne Dis. 2018;9:418-426 pubmed publisher
    ..Infection with Borrelia burgdorferi sensu stricto, Babesia microti, and Anaplasma phagocytophilum (the agents of Lyme disease, human ..