domestic silkworm

Summary

Alias: silk moth, silkworm, Bombyx mori, Bombyx mori Linnaeus, 1758

Top Publications

  1. Tabunoki H, Ode H, Banno Y, Katsuma S, Shimada T, Mita K, et al. BmDJ-1 is a key regulator of oxidative modification in the development of the silkworm, Bombyx mori. PLoS ONE. 2011;6:e17683 pubmed publisher
    We cloned cDNA for the Bombyx mori DJ-1 protein (BmDJ-1) from the brains of larvae. BmDJ-1 is composed of 190 amino acids and encoded by 672 nucleotides...
  2. Tatematsu K, Yamamoto K, Uchino K, Narukawa J, Iizuka T, Banno Y, et al. Positional cloning of silkworm white egg 2 (w-2) locus shows functional conservation and diversification of ABC transporters for pigmentation in insects. Genes Cells. 2011;16:331-42 pubmed publisher
    ..The white egg 2 (w-2) mutant of the silkworm, Bombyx mori, has white eggs and eyes because of lack of ommochrome granules in the serosa and eyes...
  3. Maeda T, Lee J, Miyagawa Y, Koga K, Kawaguchi Y, Kusakabe T. Cloning and characterization of a ribonuclease L inhibitor from the silkworm, Bombyx mori. DNA Seq. 2005;16:21-7 pubmed
    ..In the present study, we cloned a cDNA of a silkworm RLI homolog, termed BmRLI, and its nucleotide sequence was determined...
  4. Atsumi S, Miyamoto K, Yamamoto K, Narukawa J, Kawai S, Sezutsu H, et al. Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin Cry1Ab in the silkworm, Bombyx mori. Proc Natl Acad Sci U S A. 2012;109:E1591-8 pubmed publisher
    ..By using Bombyx mori as a model, we identified a candidate gene for a recessive form of resistance to Cry1Ab toxin on chromosome 15 ..
  5. Gu S, Yeh W, Young S, Lin P, Li S. TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori. Insect Biochem Mol Biol. 2012;42:296-303 pubmed publisher
    ..that phosphoinositide 3-kinase (PI3K)/Akt signaling was involved in PTTH-stimulated ecdysteroidogenesis by Bombyx mori prothoracic glands. In the present study, downstream signaling of PI3K/Akt was further investigated...
  6. Li Z, Cheng D, Mon H, Tatsuke T, Zhu L, Xu J, et al. Genome-wide identification of polycomb target genes reveals a functional association of Pho with Scm in Bombyx mori. PLoS ONE. 2012;7:e34330 pubmed publisher
    ..Here, we identified Polycomb target genes in Bombyx mori with holocentric centromere using genome-wide expression screening based on the knockdown of BmSCE, BmESC, ..
  7. Abraham E, Sezutsu H, Kanda T, Sugasaki T, Shimada T, Tamura T. Identification and characterisation of a silkworm ABC transporter gene homologous to Drosophila white. Mol Gen Genet. 2000;264:11-9 pubmed
    In the silkworm, Bombyx mori, many eye- and egg-colour mutations affecting the synthesis and accumulation of ommochrome pigments have been described...
  8. Kômoto N, Quan G, Sezutsu H, Tamura T. A single-base deletion in an ABC transporter gene causes white eyes, white eggs, and translucent larval skin in the silkworm w-3(oe) mutant. Insect Biochem Mol Biol. 2009;39:152-6 pubmed publisher
    The w-3(oe) silkworm mutant has white eyes and eggs due to the absence of ommochrome pigments in the eye pigment cells and serosa cells...
  9. Ohta H, Tsuchihara K, Mitsumasu K, Yaginuma T, Ozoe Y, Asaoka K. Comparative pharmacology of two D1-like dopamine receptors cloned from the silkworm Bombyx mori. Insect Biochem Mol Biol. 2009;39:342-7 pubmed
    ..We recently cloned two DA receptors (BmDopR1 and BmDopR2) from the silkworm Bombyx mori and identified them as D1-like receptors, which activate adenylate cyclase to increase intracellular cAMP ..

More Information

Publications332 found, 100 shown here

  1. Zhou J, Robertson G, He X, Dufour S, Hooper A, Pickett J, et al. Characterisation of Bombyx mori Odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components. J Mol Biol. 2009;389:529-45 pubmed publisher
    ..In the silkworm Bombyx mori, the OBPs are subdivided into three main subfamilies; pheromone-binding proteins (PBPs), general odorant-..
  2. Mitsumasu K, Ohta H, Tsuchihara K, Asaoka K, Ozoe Y, Niimi T, et al. Molecular cloning and characterization of cDNAs encoding dopamine receptor-1 and -2 from brain-suboesophageal ganglion of the silkworm, Bombyx mori. Insect Mol Biol. 2008;17:185-95 pubmed publisher
    ..between dopamine and the release of diapause hormone into the blood, we cloned and characterized cDNAs encoding Bombyx mori dopamine receptor-1 and -2 (BmDopR1 and 2) from the pupal brain-suboesophageal ganglion...
  3. Kawaoka S, Katsuma S, Daimon T, Isono R, Omuro N, Mita K, et al. Functional analysis of four Gloverin-like genes in the silkworm, Bombyx mori. Arch Insect Biochem Physiol. 2008;67:87-96 pubmed publisher
    To identify genes involved in the innate immunity of the silkworm Bombyx mori, we constructed a cDNA library from the fat body of Escherichia coli-challenged B. mori larvae...
  4. Masumoto M, Yaginuma T, Niimi T. Functional analysis of Ultrabithorax in the silkworm, Bombyx mori, using RNAi. Dev Genes Evol. 2009;219:437-44 pubmed publisher
    ..We examined the function of Ubx in the silkworm Bombyx mori (Bm-Ubx) by embryonic RNA interference (RNAi)...
  5. Kinjoh T, Kaneko Y, Itoyama K, Mita K, Hiruma K, Shinoda T. Control of juvenile hormone biosynthesis in Bombyx mori: cloning of the enzymes in the mevalonate pathway and assessment of their developmental expression in the corpora allata. Insect Biochem Mol Biol. 2007;37:808-18 pubmed
    ..of all enzymes involved in the mevalonate pathway portion of the juvenile hormone (JH) biosynthetic pathway in Bombyx mori, i.e., those responsible for the formation of farnesyl diphosphate from acetyl-CoA...
  6. Anderson A, Wanner K, Trowell S, Warr C, Jaquin Joly E, Zagatti P, et al. Molecular basis of female-specific odorant responses in Bombyx mori. Insect Biochem Mol Biol. 2009;39:189-97 pubmed publisher
    ..Previously, we identified genes encoding putative odorant receptors (ORs) from the genome of the silkworm, Bombyx mori, some of which have higher levels of steady-state transcript in the antennae of adult females compared with ..
  7. Sandrelli F, Cappellozza S, Benna C, Saviane A, Mastella A, Mazzotta G, et al. Phenotypic effects induced by knock-down of the period clock gene in Bombyx mori. Genet Res. 2007;89:73-84 pubmed publisher
    The lepidopteran Bombyx mori is an insect of considerable scientific and economic importance. Recently, the B. mori circadian clock gene period has been molecularly characterized. We have transformed a B...
  8. Duan J, Xu H, Wang F, Ma S, Zha X, Guo H, et al. Novel female-specific trans-spliced and alternative splice forms of dsx in the silkworm Bombyx mori. Biochem Biophys Res Commun. 2013;431:630-5 pubmed publisher
    The Bombyx mori doublesex gene (Bmdsx) plays an important role in somatic sexual development. Its pre-mRNA splices in a sex-specific manner to generate two female-specific and one male-specific splice forms...
  9. Daimon T, Taguchi T, Meng Y, Katsuma S, Mita K, Shimada T. Beta-fructofuranosidase genes of the silkworm, Bombyx mori: insights into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex. J Biol Chem. 2008;283:15271-9 pubmed publisher
    ..Although these compounds do not harm the silkworm, Bombyx mori, a mulberry specialist, they are highly toxic to insects that do not normally feed on mulberry leaves...
  10. Mitsumasu K, Azuma M, Niimi T, Yamashita O, Yaginuma T. Changes in the expression of soluble and integral-membrane trehalases in the midgut during metamorphosis in Bombyx mori. Zoolog Sci. 2008;25:693-8 pubmed publisher
    To elucidate the relationship between soluble trehalase (Treh1) and integral-membrane trehalase (Treh2) in the Bombyx mori midgut, expression profiles for both proteins and mRNAs were examined during metamorphosis by using Western-..
  11. Yamamoto K, Ichinose H, Aso Y, Banno Y, Kimura M, Nakashima T. Molecular characterization of an insecticide-induced novel glutathione transferase in silkworm. Biochim Biophys Acta. 2011;1810:420-6 pubmed publisher
    ..Kinetic analysis of bmGSTu mutants indicated that Tyr7, Ser12 and Asn50 are involved in enzyme function. These results support the hypothesis that bmGSTu may play a role in insecticide resistance in Bombyx mori.
  12. Sakudoh T, Sezutsu H, Nakashima T, Kobayashi I, Fujimoto H, Uchino K, et al. Carotenoid silk coloration is controlled by a carotenoid-binding protein, a product of the Yellow blood gene. Proc Natl Acad Sci U S A. 2007;104:8941-6 pubmed publisher
    ..The Y (Yellow blood) gene, a critical cocoon color determinant in the silkworm Bombyx mori, controls the uptake of carotenoids into the intestinal mucosa and the silk gland...
  13. Itoh M, Kanamori Y, Takao M, Eguchi M. Cloning of soluble alkaline phosphatase cDNA and molecular basis of the polymorphic nature in alkaline phosphatase isozymes of Bombyx mori midgut. Insect Biochem Mol Biol. 1999;29:121-9 pubmed
    A cDNA coding for soluble type alkaline phosphatase (sALP) of Bombyx mori was isolated. Deduced amino acid sequence showed high identities to various ALPs and partial similarities to ATPase of Manduca sexta...
  14. Adachi Yamada T, Iwami M, Kataoka H, Suzuki A, Ishizaki H. Structure and expression of the gene for the prothoracicotropic hormone of the silkmoth Bombyx mori. Eur J Biochem. 1994;220:633-43 pubmed
    We cloned and characterized two allelic variants of the gene for the Bombyx mori prothoracicotropic hormone (PTTH), a homodimeric 30-kDa brain secretory protein...
  15. Wen H, Lan X, Cheng T, He N, Shiomi K, Kajiura Z, et al. Sequence structure and expression pattern of a novel anionic defensin-like gene from silkworm (Bombyx mori). Mol Biol Rep. 2009;36:711-6 pubmed publisher
    A defensin-like gene, BmdefA, was rediscovered in the silkworm genome and expressed sequence tags databases...
  16. Kaneko Y, Tanaka H, Ishibashi J, Iwasaki T, Yamakawa M. Gene expression of a novel defensin antimicrobial peptide in the silkworm, Bombyx mori. Biosci Biotechnol Biochem. 2008;72:2353-61 pubmed publisher
    cDNA encoding a novel defensin (BmDefensinB) was cloned from the fat body of the silkworm, Bombyx mori, and gene expression was analyzed. BmDefensinB showed typical structural characteristics of invertebrate defensins...
  17. Koizumi N, Imamura M, Kadotani T, Yaoi K, Iwahana H, Sato R. The lipopolysaccharide-binding protein participating in hemocyte nodule formation in the silkworm Bombyx mori is a novel member of the C-type lectin superfamily with two different tandem carbohydrate-recognition domains. FEBS Lett. 1999;443:139-43 pubmed
    ..characterized the lipopolysaccharide (LPS)-binding protein, BmLBP, from the larval hemolymph of the silkworm Bombyx mori. BmLBP is a pattern recognition molecule that recognizes the lipid A portion of LPS and participates in a ..
  18. Osanai M, Kojima K, Futahashi R, Yaguchi S, Fujiwara H. Identification and characterization of the telomerase reverse transcriptase of Bombyx mori (silkworm) and Tribolium castaneum (flour beetle). Gene. 2006;376:281-9 pubmed publisher
    ..In contrast, the domestic silkworm Bombyx mori contains TTAGG-type telomeric repeats, but the telomerase activity has not been detected in all ..
  19. Xu W, Sato Y, Ikeda M, Yamashita O. Molecular characterization of the gene encoding the precursor protein of diapause hormone and pheromone biosynthesis activating neuropeptide (DH-PBAN) of the silkworm, Bombyx mori and its distribution in some insects. Biochim Biophys Acta. 1995;1261:83-9 pubmed
    The diapause hormone is a 24 amino acid peptide amide which induces embryonic diapause of the silkworm, Bombyx mori. Diapause hormone, pheromone biosynthesis activating neuropeptide, and other three neuropeptides of FXPRL amide peptide ..
  20. Lee W, Lee J, Kravchenko V, Ulevitch R, Brey P. Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Proc Natl Acad Sci U S A. 1996;93:7888-93 pubmed
    ..having strong affinity to the cell wall of Gram(-) bacteria, was purified from the hemolymph of the silkworm, Bombyx mori. The cDNA encoding this Gram(-) bacteria-binding protein (GNBP) was isolated from an immunized silkworm fat ..
  21. Ochiai M, Ashida M. A pattern-recognition protein for beta-1,3-glucan. The binding domain and the cDNA cloning of beta-1,3-glucan recognition protein from the silkworm, Bombyx mori. J Biol Chem. 2000;275:4995-5002 pubmed
    ..We cloned the cDNA of the betaGRP of the silkworm Bombyx mori. The betaGRP mRNA transcript was constitutively expressed in the hemocytes, fat body, and epithelial cells of ..
  22. Gu S, Young S, Tsai W, Lin J, Lin P. Involvement of 4E-BP phosphorylation in embryonic development of the silkworm, Bombyx mori. J Insect Physiol. 2011;57:978-85 pubmed publisher
    ..In the present study, we investigated 4E-BP phosphorylation of Bombyx mori eggs by an immunoblot analysis of a conserved phospho-specific antibody to 4E-BP and demonstrated its role ..
  23. Mori S, Izumi S, Tomino S. Complete nucleotide sequences of major plasma protein genes of Bombyx mori. Biochim Biophys Acta. 1991;1090:129-32 pubmed
    In the silkworm, Bombyx mori, a family of hormone-sensitive genes encodes major plasma proteins, termed '30K proteins'...
  24. Takeda M, Mita K, Quan G, Shimada T, Okano K, Kanke E, et al. Mass isolation of cuticle protein cDNAs from wing discs of Bombyx mori and their characterizations. Insect Biochem Mol Biol. 2001;31:1019-28 pubmed
    ..All the isolated genes were expressed in the head, thoracic, and abdominal regions of the epidermis at different levels around pupation, but no expression was observed in the epidermis at the fourth molting stage. ..
  25. Warren J, Petryk A, Marqu s G, Parvy J, Shinoda T, Itoyama K, et al. Phantom encodes the 25-hydroxylase of Drosophila melanogaster and Bombyx mori: a P450 enzyme critical in ecdysone biosynthesis. Insect Biochem Mol Biol. 2004;34:991-1010 pubmed publisher
    ..gene identification has also resulted in the characterization of the corresponding 25-hydroxylase gene in Bombyx mori. Confirmation of 2,22,25-trideoxyecdysone (3beta,5beta-ketodiol) conversion to 2,22-dideoxyecdysone (3beta,..
  26. Wang X, Chen J, Lv Z, Nie Z, Wang D, Shen H, et al. Expression and functional analysis of the cellular retinoic acid binding protein from silkworm pupae (Bombyx mori). J Cell Biochem. 2007;102:970-9 pubmed publisher
    ..We have cloned the CRABP gene from silkworm pupae and studied the interaction between Bombyx mori CRABP (BmCRABP) and all-trans retinoic acid (atRA)...
  27. Wang Z, Zhao M, Li D, Zha X, Xia Q, Xiang Z, et al. BmHrp28 is a RNA-binding protein that binds to the female-specific exon 4 of Bombyx mori dsx pre-mRNA. Insect Mol Biol. 2009;18:795-803 pubmed publisher
    The Bombyx mori sex determination gene Bmdsx is alternatively spliced in the male and female to produce the male- and female-specific proteins...
  28. Tanoue S, Sumida S, Suetsugu T, Endo Y, Nishioka T. Identification of a receptor type guanylyl cyclase in the antennal lobe and antennal sensory neurons of the silkmoth, Bombyx mori. Insect Biochem Mol Biol. 2001;31:971-9 pubmed
    ..In the antennae of the male silkmoth Bombyx mori, receptor type GC are supposed to mediate signaling of pheromone...
  29. Mita K, Kasahara M, Sasaki S, Nagayasu Y, Yamada T, Kanamori H, et al. The genome sequence of silkworm, Bombyx mori. DNA Res. 2004;11:27-35 pubmed
    We performed threefold shotgun sequencing of the silkworm (Bombyx mori) genome to obtain a draft sequence and establish a basic resource for comprehensive genome analysis...
  30. Liu X, Tanaka Y, Song Q, Xu B, Hua Y. Bombyx mori prothoracicostatic peptide inhibits ecdysteroidogenesis in vivo. Arch Insect Biochem Physiol. 2004;56:155-61 pubmed publisher
    ..prothoracicotropic hormone (PTTH)-stimulated ecdysteroid biosynthesis in the prothoracic gland of the silkworm, Bombyx mori. In the present report, Bom-PTSP has been shown to significantly decrease hemolymph ecdysteroid titer in the ..
  31. Nishita Y. Ecdysone response elements in the distal promoter of the Bombyx Broad-Complex gene, BmBR-C. Insect Mol Biol. 2014;23:341-56 pubmed publisher
    The Bombyx mori silkworm's homologue of the Broad-Complex gene (BmBR-C) is transcribed from two promoters: a distal promoter (Pdist) and a proximal promoter (Pprox)...
  32. Sasaki T. Patchwork-structure serpins from silkworm (Bombyx mori) larval hemolymph. Eur J Biochem. 1991;202:255-61 pubmed
    A new serpin (serine proteinase inhibitor), having antichymotryptic activity, was isolated from silkworm, Bombyx mori, larval hemolymph and was named silkworm antichymotrypsin II (sw-AchyII)...
  33. Kitamura A, Nagasawa H, Kataoka H, Inoue T, Matsumoto S, Ando T, et al. Amino acid sequence of pheromone-biosynthesis-activating neuropeptide (PBAN) of the silkworm, Bombyx mori. Biochem Biophys Res Commun. 1989;163:520-6 pubmed
    ..PBAN), named PBAN-I and -II, as fully oxidized forms of Met residues from adult heads of the silkworm, Bombyx mori. PBAN-I was identical with the PBAN which we had isolated before...
  34. Mang A, Julien E, Prudhomme J, Couble P. A strong inhibitory element down-regulates SRE-stimulated transcription of the A3 cytoplasmic actin gene of Bombyx mori. J Mol Biol. 1997;265:266-74 pubmed publisher
    To identify the functional regulatory elements of the promoter of the cytoplasmic actin A3 gene in Bombyx mori, transient expression of A3-LacZ mutants was assayed in cultured Lepidoptera cells...
  35. Landais I, Pommet J, Mita K, Nohata J, Gimenez S, Fournier P, et al. Characterization of the cDNA encoding the 90 kDa heat-shock protein in the Lepidoptera Bombyx mori and Spodoptera frugiperda. Gene. 2001;271:223-31 pubmed
    This report presents the first hsp90 complete cDNA sequences from two Lepidoptera. The Bombyx mori full sequence was reconstituted from 15 partial cDNA clones belonging to expressed sequence tag libraries obtained from different tissues ..
  36. Hull J, Kajigaya R, Imai K, Matsumoto S. Sex pheromone production in the silkworm, Bombyx mori, is mediated by store-operated Ca2+ channels. Biosci Biotechnol Biochem. 2007;71:1993-2001 pubmed
    ..Fluorescent Ca(2+) imaging techniques confirmed PBAN-induced Ca(2+) influx in the silkworm, Bombyx mori, and showed that the PBAN response is reduced with repeated stimulation...
  37. Seino A, Ogura T, Tsubota T, Shimomura M, Nakakura T, Tan A, et al. Characterization of juvenile hormone epoxide hydrolase and related genes in the larval development of the silkworm Bombyx mori. Biosci Biotechnol Biochem. 2010;74:1421-9 pubmed
    ..By searching a genome database of the silkworm, KAIKOBLAST, five JHEH-related genes (jheh-r), in addition to Bmjheh, were found...
  38. Takiya S, Nishita Y, Ishikawa S, Ohno K, Tamura T, Suzuki Y. Bombyx Y-box protein BYB facilitates specific DNA interaction of various DNA binding proteins independently of the cold shock domain. J Biochem. 2004;135:683-93 pubmed
    A new member of the Y-box protein family of the silkworm Bombyx mori (BYB) was co-purified with the fibroin gene enhancer-binding protein FMBP-1, and stimulated the binding of FMBP-1 to its cognate DNA element...
  39. Sato K, Matsunaga T, Futahashi R, Kojima T, Mita K, Banno Y, et al. Positional cloning of a Bombyx wingless locus flugellos (fl) reveals a crucial role for fringe that is specific for wing morphogenesis. Genetics. 2008;179:875-85 pubmed publisher
    Mutations at the flügellos (fl) locus in Bombyx mori produce wingless pupae and moths because of the repressed response of wing discs to ecdysteroid. Four recessive fl alleles occurred spontaneously and were mapped at 13...
  40. Liu W, Yang F, Jia S, Miao X, Huang Y. Cloning and characterization of Bmrunt from the silkworm Bombyx mori during embryonic development. Arch Insect Biochem Physiol. 2008;69:47-59 pubmed publisher
    ..We cloned the homologue of runt in the silkworm Bombyx mori, an intermediate germband-type insect...
  41. Hull J, Lee J, Kajigaya R, Matsumoto S. Bombyx mori homologs of STIM1 and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production. J Biol Chem. 2009;284:31200-13 pubmed publisher
    Sex pheromone production in the pheromone gland (PG) of the silkmoth, Bombyx mori, is mediated by store-operated channels (SOCs) acting downstream of pheromone biosynthesis activating neuropeptide (PBAN) binding...
  42. Bao Y, Xue J, Wu W, Wang Y, Lv Z, Zhang C. An immune-induced reeler protein is involved in the Bombyx mori melanization cascade. Insect Biochem Mol Biol. 2011;41:696-706 pubmed publisher
    In this study, we isolated two reeler cDNAs from bacteria-challenged larval fat bodies of the silkworm, Bombyx mori. A reeler domain spanned most of the coding regions of these two cDNAs, and their expression patterns were different in B...
  43. Sugiyama M, Kuniyoshi H, Kotani E, Taniai K, Kadono Okuda K, Kato Y, et al. Characterization of a Bombyx mori cDNA encoding a novel member of the attacin family of insect antibacterial proteins. Insect Biochem Mol Biol. 1995;25:385-92 pubmed
    A Bombyx mori cDNA was cloned that hybridized with Hyalophora cecropia attacin probe and its nucleotide sequence was determined...
  44. Pelletier J, Bozzolan F, Solvar M, Fran ois M, Jacquin Joly E, Ma b che Coisne M. Identification of candidate aldehyde oxidases from the silkworm Bombyx mori potentially involved in antennal pheromone degradation. Gene. 2007;404:31-40 pubmed publisher
    ..In the silkworm Bombyx mori, one of the best models for studying olfaction in insects, the involvement of an antennal-specific aldehyde ..
  45. Sakudoh T, Kuwazaki S, Iizuka T, Narukawa J, Yamamoto K, Uchino K, et al. CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori. J Lipid Res. 2013;54:482-95 pubmed publisher
    ..The products of the Yellow cocoon (C) gene and the Flesh (F) gene of the silkworm Bombyx mori determine the selectivity for transport of lutein and ?-carotene, respectively, to the silk gland...
  46. Wang G, Jiang L, Zhu L, Cheng T, Niu W, Yan Y, et al. Characterization of Argonaute family members in the silkworm, Bombyx mori. Insect Sci. 2013;20:78-91 pubmed publisher
    ..Here, four members of the Argonaute family were systemically identified based on the genome sequence of Bombyx mori. Based on their sequence similarity, BmAgo1 and BmAgo2 belong to the Ago subfamily, while BmAgo3 and BmPiwi are ..
  47. Fujiwara Y, Tanaka Y, Iwata K, Rubio R, Yaginuma T, Yamashita O, et al. ERK/MAPK regulates ecdysteroid and sorbitol metabolism for embryonic diapause termination in the silkworm, Bombyx mori. J Insect Physiol. 2006;52:569-75 pubmed publisher
    The eggs of the silkworm Bombyx mori undergo a state of suspended overt development and diminished metabolism called "diapause" to escape adverse environmental conditions...
  48. Mach V, Takiya S, Ohno K, Handa H, Imai T, Suzuki Y. Silk gland factor-1 involved in the regulation of Bombyx sericin-1 gene contains fork head motif. J Biol Chem. 1995;270:9340-6 pubmed
    ..The SGF-1 protein contains putative transactivation domains. We conclude that the 40- and 41-kDa SGF-1 proteins affect transcription of the sericin-1 gene via binding to the SA site. ..
  49. Iwasaki H, Takahashi M, Niimi T, Yamashita O, Yaginuma T. Cloning of cDNAs encoding Bombyx homologues of Cdc2 and Cdc2-related kinase from eggs. Insect Mol Biol. 1997;6:131-41 pubmed
    In diapausing eggs of the silkworm Bombyx mori, embryonic cells are arrested at G2 phase. The ability to undertake cell division is resumed in the course of diapause termination caused by such a treatment as acclimation to 5 degrees C...
  50. Shofuda K, Togawa T, Nakato H, Tomino S, Izumi S. Molecular cloning and characterization of a cDNA encoding a larval cuticle protein of Bombyx mori. Comp Biochem Physiol B Biochem Mol Biol. 1999;122:105-9 pubmed
    Cuticle proteins termed LCPs are the major protein components of the larval integument of the silkworm, Bombyx mori. We purified an 18 kDa LCP (LCP18) from the guanidine hydrochloride extract of the larval cuticle and identified an LCP18 ..
  51. Katsuma S, Mita K, Shimada T. ERK- and JNK-dependent signaling pathways contribute to Bombyx mori nucleopolyhedrovirus infection. J Virol. 2007;81:13700-9 pubmed
    ..intracellular signaling pathways induced by baculovirus infection, we examined the involvement of MAPKs in Bombyx mori nucleopolyhedrovirus (BmNPV) infection of BmN cells...
  52. Sosalegowda A, Kundapur R, Boregowda M. Molecular characterization of heat shock proteins 90 (HSP83?) and 70 in tropical strains of Bombyx mori. Proteomics. 2010;10:2734-45 pubmed publisher
    Following the concept of whole organism, we have extracted total protein from the Bombyx mori for the identification and analysis of HSPs...
  53. Ma L, Liu S, Shi M, Chen X, Li S. Ras1CA-upregulated BCPI inhibits cathepsin activity to prevent tissue destruction of the Bombyx posterior silk gland. J Proteome Res. 2013;12:1924-34 pubmed publisher
    Using the GAL4/UAS transgenic system established in the silkworm, Bombyx mori, we have previously reported that overexpression of the Ras1(CA) oncogene specifically in the posterior silk gland (PSG) resulted in improved fibroin synthesis,..
  54. Xia Q, Fujii H, Kusakabe T, Banno Y. Identification of three annexin IX isoforms generated by alternative splicing of the carboxyl-terminal exon in silkworm, Bombyx mori. Insect Biochem Mol Biol. 2001;32:9-14 pubmed
    ..the cloning of three cDNAs each encoding annexin IX (ANX IX) isoforms from unfertilized eggs of the silkworm, Bombyx mori. The analysis of exon/intron structures showed that the three mRNAs, named ANX IX-A (2300bp), ANX IX-B (1884bp) ..
  55. Jin Y, Tian N, Cao J, Liang J, Yang Z, Lv J. RNA editing and alternative splicing of the insect nAChR subunit alpha6 transcript: evolutionary conservation, divergence and regulation. BMC Evol Biol. 2007;7:98 pubmed publisher
    ..from different insects spanning ~300 million years of evolution- Drosophila melanogaster, Anopheles gambiae, Bombyx mori, Tribolium castaneum and Apis mellifera...
  56. Yoshida H, Kinoshita K, Ashida M. Purification of a peptidoglycan recognition protein from hemolymph of the silkworm, Bombyx mori. J Biol Chem. 1996;271:13854-60 pubmed
    A method was developed for obtaining a homogeneous silkworm hemolymph protein (peptidoglycan recognition protein, PGRP) which has affinity for peptidoglycan and the ability to trigger the prophenoloxidase cascade upon its binding to ..
  57. Krieger J, Klink O, Mohl C, Raming K, Breer H. A candidate olfactory receptor subtype highly conserved across different insect orders. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2003;189:519-26 pubmed
    ..the identification of HR2 homologues in two further lepidopteran species, the moths Antheraea pernyi and Bombyx mori, which share 86-88% of their amino acids...
  58. Suzuki Y, Matsuoka T, Iimura Y, Fujiwara H. Ecdysteroid-dependent expression of a novel cuticle protein gene BMCPG1 in the silkworm, Bombyx mori. Insect Biochem Mol Biol. 2002;32:599-607 pubmed
    ..the differential display method to look for stage-specific cuticle genes, and identified a novel cDNA named Bombyx mori Cuticle Protein GlyGlyTyr-repeat 1 (BMCPG1)...
  59. Sakudoh T, Iizuka T, Narukawa J, Sezutsu H, Kobayashi I, Kuwazaki S, et al. A CD36-related transmembrane protein is coordinated with an intracellular lipid-binding protein in selective carotenoid transport for cocoon coloration. J Biol Chem. 2010;285:7739-51 pubmed publisher
    The transport pathway of specific dietary carotenoids from the midgut lumen to the silk gland in the silkworm, Bombyx mori, is a model system for selective carotenoid transport because several genetic mutants with defects in parts of ..
  60. Kiuchi T, Banno Y, Katsuma S, Shimada T. Mutations in an amino acid transporter gene are responsible for sex-linked translucent larval skin of the silkworm, Bombyx mori. Insect Biochem Mol Biol. 2011;41:680-7 pubmed publisher
    The sex-linked translucent (os) mutation in the silkworm, Bombyx mori, confers slightly translucent larval skin resulting from a decrease in the incorporation of uric acid into epidermal cells...
  61. Uno T, Sakamoto K, Isoyama Y, Hiragaki S, Uno Y, Kanamaru K, et al. Relationship between the expression of Rab family GTPases and neuropeptide hormones in the brain of Bombyx mori. Histochem Cell Biol. 2013;139:299-308 pubmed publisher
    ..this study, we examined the expression of Rab proteins and neuropeptide hormones in the brain of the silkworm, Bombyx mori. We produced antibodies against B. mori Rab1 and Rab14 in rabbits...
  62. Fujiwara Y, Yamashita O. Gene structure of Bombyx mori larval serum protein (BmLSP). Insect Mol Biol. 1992;1:63-9 pubmed
    To understand the molecular mechanisms of the larval-specific transcription of Bombyx mori larval serum protein (BmLSP), we isolated a clone of the BmLSP gene from a genomic library and sequenced a 3.5-kb fragment...
  63. Yasuhara Y, Koizumi Y, Katagiri C, Ashida M. Reexamination of properties of prophenoloxidase isolated from larval hemolymph of the silkworm Bombyx mori. Arch Biochem Biophys. 1995;320:14-23 pubmed publisher
    Prophenoloxidase in hemolymph of the silkworm (Bombyx mori) was purified by the method of Ashida (Ashida, M. (1971) Arch. Biochem. Biophys...
  64. Byeon G, Lee K, Gui Z, Kim I, Kang P, Lee S, et al. A digestive beta-glucosidase from the silkworm, Bombyx mori: cDNA cloning, expression and enzymatic characterization. Comp Biochem Physiol B Biochem Mol Biol. 2005;141:418-27 pubmed publisher
    A digestive beta-glucosidase cDNA was cloned from the silkworm, Bombyx mori. The B. mori beta-glucosidase cDNA contains an open reading frame of 1473 bp encoding 491 amino acid residues. The B...
  65. Xia A, Zhou Q, Yu L, Li W, Yi Y, Zhang Y, et al. Identification and analysis of YELLOW protein family genes in the silkworm, Bombyx mori. BMC Genomics. 2006;7:195 pubmed
    ..a gene family composed of seven members with a conserved MRJP domain each and named it YELLOW protein family of Bombyx mori. We completed the cDNA sequences with RACE method...
  66. Tomoyasu Y, Miller S, Tomita S, Schoppmeier M, Grossmann D, Bucher G. Exploring systemic RNA interference in insects: a genome-wide survey for RNAi genes in Tribolium. Genome Biol. 2008;9:R10 pubmed publisher
    ..Thus, insects may use an alternative mechanism for the systemic RNAi response. Understanding this process would assist with rendering other insects amenable to systemic RNAi, and may influence pest control approaches. ..
  67. Kawaoka S, Katsuma S, Meng Y, Hayashi N, Mita K, Shimada T. Identification and characterization of globin genes from two lepidopteran insects, Bombyx mori and Samia cynthia ricini. Gene. 2009;431:33-8 pubmed publisher
    We describe the characterization of hemoglobin-like genes from two lepidopteran insects, Bombyx mori (Bmglobin) and Samia cynthia ricini (Scglobin)...
  68. Zhang J, Pan M, Sun Z, Huang S, Yu Z, Liu D, et al. The genomic underpinnings of apoptosis in the silkworm, Bombyx mori. BMC Genomics. 2010;11:611 pubmed publisher
    ..Herein we have identified apoptosis-related genes in the silkworm Bombyx mori and compared them to those from insects, mammals, and nematodes...
  69. Zhan S, Guo Q, Li M, Li M, Li J, Miao X, et al. Disruption of an N-acetyltransferase gene in the silkworm reveals a novel role in pigmentation. Development. 2010;137:4083-90 pubmed publisher
    ..The melanism (mln) mutant of the silkworm Bombyx mori is notable for its strong black coloration, phenotypic differences between larval and adult stages, and its ..
  70. Koizumi N, Morozumi A, Imamura M, Tanaka E, Iwahana H, Sato R. Lipopolysaccharide-binding proteins and their involvement in the bacterial clearance from the hemolymph of the silkworm Bombyx mori. Eur J Biochem. 1997;248:217-24 pubmed
    ..R) mutant) were isolated and purified by affinity precipitation from the larval hemolymph of the silkworm Bombyx mori. These proteins were found to consist of two components with molecular masses of 43 kDa and 40 kDa by SDS/PAGE...
  71. Nagamatsu Y, Toda S, Koike T, Miyoshi Y, Shigematsu S, Kogure M. Cloning, sequencing, and expression of the Bombyx mori receptor for Bacillus thuringiensis insecticidal CryIA(a) toxin. Biosci Biotechnol Biochem. 1998;62:727-34 pubmed publisher
    ..CryIA(a) toxin binds to a 175-kDa glycoprotein (BtR175) on the microvillus membranes of columnar cells in the Bombyx mori midgut and causes lysis of the cells. BtR175 was purified, and its cDNA was cloned...
  72. Uhlirova M, Foy B, Beaty B, Olson K, Riddiford L, Jindra M. Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis. Proc Natl Acad Sci U S A. 2003;100:15607-12 pubmed
    ..Here we use a recombinant Sindbis virus as a tool to silence BR-C expression in the silkmoth Bombyx mori. The virus expressing a BR-C antisense RNA fragment reduced endogenous BR-C mRNA levels in infected tissues (..
  73. Chen X, Ohta H, Ozoe F, Miyazawa K, Huang J, Ozoe Y. Functional and pharmacological characterization of a beta-adrenergic-like octopamine receptor from the silkworm Bombyx mori. Insect Biochem Mol Biol. 2010;40:476-86 pubmed publisher
    A cDNA encoding a seven-transmembrane receptor was cloned from the nervous tissues of silkworm (Bombyx mori) larvae...
  74. Michel E, Damberger F, Ishida Y, Fiorito F, Lee D, Leal W, et al. Dynamic conformational equilibria in the physiological function of the Bombyx mori pheromone-binding protein. J Mol Biol. 2011;408:922-31 pubmed publisher
    The Bombyx mori pheromone-binding protein (BmorPBP) undergoes a pH-dependent conformational transition from a form at basic pH, which contains an open cavity suitable for ligand binding (BmorPBP(B)), to a form at pH 4...
  75. Sakurai H, Fujii T, Izumi S, Tomino S. Complete nucleotide sequence of gene for sex-specific storage protein of Bombyx mori. Nucleic Acids Res. 1988;16:7717-8 pubmed
  76. Zhang T, Kang L, Zhang Z, Xu W. Identification of a POU factor involved in regulating the neuron-specific expression of the gene encoding diapause hormone and pheromone biosynthesis-activating neuropeptide in Bombyx mori. Biochem J. 2004;380:255-63 pubmed publisher
    ..In the present study, we report two Bombyx mori transcription factors interacting specifically with the promoter of Bom-DH-PBAN (where Bom-DH stands for B...
  77. Gu S, Young S, Lin J, Lin P. Involvement of PI3K/Akt signaling in PTTH-stimulated ecdysteroidogenesis by prothoracic glands of the silkworm, Bombyx mori. Insect Biochem Mol Biol. 2011;41:197-202 pubmed publisher
    ..and tyrosine kinase are involved in PTTH-stimulated ecdysteroidogenesis by the prothoracic glands of both Bombyx mori and Manduca sexta...
  78. Hara S, Yamakawa M. Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori. J Biol Chem. 1995;270:29923-7 pubmed
    ..shows antibacterial activity against Staphylococcus aureus was isolated from the hemolymph of the silkworm, Bombyx mori. The novel peptide consisted of 42 amino acids and was highly basic...
  79. Hua G, Tsukamoto K, Ikezawa H. Cloning and sequence analysis of the aminopeptidase N isozyme (APN2) from Bombyx mori midgut. Comp Biochem Physiol B Biochem Mol Biol. 1998;121:213-22 pubmed
    ..phospholipase C (PI-PLC) and purified homogeneously, from the brush border membrane of Bombyx mori. From the result of cDNA cloning, the primary structure of 90 kDa APN proved to consist of 948 amino acid ..
  80. Hua Y, Tanaka Y, Nakamura K, Sakakibara M, Nagata S, Kataoka H. Identification of a prothoracicostatic peptide in the larval brain of the silkworm, Bombyx mori. J Biol Chem. 1999;274:31169-73 pubmed
    ..ecdysteroid biosynthesis in the PG was isolated from the extracts of 2,000 larval brains of the silkworm, Bombyx mori, using a protocol that included four reversed-phase high performance liquid chromatography procedures...
  81. Abdel Banat B, Koga D. Alternative splicing of the primary transcript generates heterogeneity within the products of the gene for Bombyx mori chitinase. J Biol Chem. 2002;277:30524-34 pubmed publisher
    The gene of chitinase in the silkworm, Bombyx mori, generates four mRNA products by alternative splicing...
  82. Miura N, Atsumi S, Tabunoki H, Sato R. Expression and localization of three G protein alpha subunits, Go, Gq, and Gs, in adult antennae of the silkmoth (Bombyx mori). J Comp Neurol. 2005;485:143-52 pubmed publisher
    ..classes of G protein alpha subunits, Bm Go, Bm Gq, and Bm Gs, from the antennae of the adult male silkmoth (Bombyx mori)...
  83. Adachi T, Tomita M, Yoshizato K. Synthesis of prolyl 4-hydroxylase alpha subunit and type IV collagen in hemocytic granular cells of silkworm, Bombyx mori: Involvement of type IV collagen in self-defense reaction and metamorphosis. Matrix Biol. 2005;24:136-54 pubmed publisher
    ..study shows that hemocytic granular cells synthesize and secrete type IV collagen (ColIV) in the silkworm Bombyx mori (B...
  84. Kludkiewicz B, Takasu Y, Fedic R, Tamura T, Sehnal F, Zurovec M. Structure and expression of the silk adhesive protein Ser2 in Bombyx mori. Insect Biochem Mol Biol. 2009;39:938-46 pubmed publisher
    Sericins are soluble silk components encoded in Bombyx mori by three genes, of which Ser1 and Ser3 have been characterized...
  85. Nagaoka S, Takata Y, Kato K. Identification of two arginases generated by alternative splicing in the silkworm, Bombyx mori. Arch Insect Biochem Physiol. 2011;76:97-113 pubmed publisher
    ..Here, we have cloned two arginase cDNAs from the silkworm, Bombyx mori. The analysis of exon/intron structures showed that the two mRNAs named bmarg-r and bmarg-f were generated from ..
  86. Liu J, Swevers L, Iatrou K, Huvenne H, Smagghe G. Bombyx mori DNA/RNA non-specific nuclease: expression of isoforms in insect culture cells, subcellular localization and functional assays. J Insect Physiol. 2012;58:1166-76 pubmed publisher
    A DNA/RNA non-specific alkaline nuclease (BmdsRNase) was isolated from the digestive juice of Bombyx mori. While originally reported to be produced by the midgut only, in this project it was found that the mRNA of this enzyme was also ..
  87. Hu X, Chen L, Yang R, Xiang X, Wu X. Molecular characterization of a peritrophic membrane protein from the silkworm, Bombyx mori. Mol Biol Rep. 2013;40:1087-95 pubmed publisher
    ..In the current study, a novel PM protein, designated as BmMtch, was identified from the silkworm, Bombyx mori. The open reading frame of BmMtch is 888 bp in length, encoding 295 amino acid residues consisting of two ..
  88. Hua G, Tsukamoto K, Rasilo M, Ikezawa H. Molecular cloning of a GPI-anchored aminopeptidase N from Bombyx mori midgut: a putative receptor for Bacillus thuringiensis CryIA toxin. Gene. 1998;214:177-85 pubmed
    An aminopeptidase N (APN) with a molecular weight of 110kDa was released from the midgut membrane of Bombyx mori by phosphatidylinositol-specific phospholipase C (PI-PLC), and purified to a homogeneous state...
  89. Inoue S, Tanaka K, Arisaka F, Kimura S, Ohtomo K, Mizuno S. Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with a 6:6:1 molar ratio. J Biol Chem. 2000;275:40517-28 pubmed
    Silk fibroin produced by the silkworm Bombyx mori consists of a heavy chain, a light chain, and a glycoprotein, P25...
  90. Imamura M, Yang J, Yamakawa M. cDNA cloning, characterization and gene expression of nitric oxide synthase from the silkworm, Bombyx mori. Insect Mol Biol. 2002;11:257-65 pubmed
    Molecular cloning and nucleotide sequencing of cDNA encoding Bombyx mori nitric oxide synthase (BmNOS) was conducted to analyse its possible role in insect immunity...
  91. Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, et al. A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science. 2004;306:1937-40 pubmed
    We report a draft sequence for the genome of the domesticated silkworm (Bombyx mori), covering 90.9% of all known silkworm genes. Our estimated gene count is 18,510, which exceeds the 13,379 genes reported for Drosophila melanogaster...
  92. Wang H, Iwanaga M, Kawasaki H. Activation of BMWCP10 promoter and regulation by BR-C Z2 in wing disc of Bombyx mori. Insect Biochem Mol Biol. 2009;39:615-23 pubmed publisher
    ..The results confirmed the role of BmBR-C Z2 in the transcription regulation of BMWCP10 and suggested the contribution of BmBR-C Z2 to BMWCP10 induction by 20E. ..