sheep

Summary

Alias: domestic sheep, lambs, wild sheep, Ovis aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, ovine

Top Publications

  1. Dervishi E, Serrano C, Joy M, Serrano M, Rodellar C, Calvo J. The effect of feeding system in the expression of genes related with fat metabolism in semitendinous muscle in sheep. Meat Sci. 2011;89:91-7 pubmed publisher
    ..Forty-four single born male lambs of the Rasa Aragonesa breed, allocated to four different dietary treatments, were used: grazing alfalfa, grazing ..
  2. Hu S, Ni W, Sai W, Zhang H, Cao X, Qiao J, et al. Sleeping Beauty-mediated knockdown of sheep myostatin by RNA interference. Biotechnol Lett. 2011;33:1949-53 pubmed publisher
    ..of myostatin was achieved by combining RNA interference and the Sleeping Beauty (SB) transposon system in sheep cells...
  3. Zhao X, Dittmer K, Blair H, Thompson K, Rothschild M, Garrick D. A novel nonsense mutation in the DMP1 gene identified by a genome-wide association study is responsible for inherited rickets in Corriedale sheep. PLoS ONE. 2011;6:e21739 pubmed publisher
    Inherited rickets of Corriedale sheep is characterized by decreased growth rate, thoracic lordosis and angular limb deformities. Previous outcross and backcross studies implicate inheritance as a simple autosomal recessive disorder...
  4. Byun S, Forrest R, Frampton C, Zhou H, Hickford J. An association between lifespan and variation in insulin-like growth factor I receptor in sheep. J Anim Sci. 2012;90:2484-7 pubmed publisher
    ..Recently, 3 alleles of ovine IGF1R were identified, but no analysis of the effect of IGF1R variation on sheep longevity has been reported...
  5. He J, Zhang B, Chu M, Wang P, Feng T, Cao G, et al. Polymorphism of insulin-like growth factor 1 gene and its association with litter size in Small Tail Han sheep. Mol Biol Rep. 2012;39:9801-7 pubmed publisher
    The insulin-like growth factor 1 (IGF1) gene was studied as a candidate gene for high prolificacy in sheep. Polymorphisms of 5' regulatory region and all four exons of IGF1 gene were detected in Small Tail Han (n = 277), Hu (n = 58), ..
  6. Gong H, Zhou H, Plowman J, Dyer J, Hickford J. Analysis of variation in the ovine ultra-high sulphur keratin-associated protein KAP5-4 gene using PCR-SSCP technique. Electrophoresis. 2010;31:3545-7 pubmed publisher
    ..In this study, we used PCR-SSCP to analyse ovine KRTAP5-4, a gene encoding a member of the KAP5 family...
  7. Heaton M, Kalbfleisch T, Petrik D, Simpson B, Kijas J, Clawson M, et al. Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheep. PLoS ONE. 2013;8:e55490 pubmed publisher
    In sheep, small ruminant lentiviruses cause an incurable, progressive, lymphoproliferative disease that affects millions of animals worldwide. Known as ovine progressive pneumonia virus (OPPV) in the U.S...
  8. Kay G, Jay N, Palmer D. The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction. Neurobiol Dis. 2011;41:614-23 pubmed publisher
    ..be the consequence of some universal intracellular event; however, time course studies on the cerebral cortex of a sheep model of the CLN6 form revealed distinct regional neurodegeneration preceded by regional glial activation, ..
  9. Chu M, Yang J, Feng T, Cao G, Fang L, Di R, et al. GDF9 as a candidate gene for prolificacy of Small Tail Han sheep. Mol Biol Rep. 2011;38:5199-204 pubmed publisher
    ..According to the sequence of ovine GDF9 gene, six pairs of primers were designed to detect single nucleotide polymorphisms of two exons of GDF9 gene ..

More Information

Publications101 found, 100 shown here

  1. Chu M, Guo X, Feng C, Li Y, Huang D, Feng T, et al. Polymorphism of 5' regulatory region of ovine FSHR gene and its association with litter size in Small Tail Han sheep. Mol Biol Rep. 2012;39:3721-5 pubmed publisher
    ..of 5' regulatory region of follicle-stimulating hormone receptor (FSHR) gene were detected in two high prolificacy sheep breeds (Small Tail Han and Hu sheep) and two low prolificacy sheep breeds (Corriedale and Chinese Merino sheep) by ..
  2. Dupre S, Dardente H, Birnie M, Loudon A, Lincoln G, Hazlerigg D. Evidence for RGS4 modulation of melatonin and thyrotrophin signalling pathways in the pars tuberalis. J Neuroendocrinol. 2011;23:725-32 pubmed publisher
    ..5-fold after melatonin treatment. Correspondingly, RGS4 expression is acutely sensitive to changing day length. In sheep acclimated to short days (SP, 8 h light/day), RGS4 expression increases sharply following dark onset, peaking in ..
  3. Vage D, Husdal M, Kent M, Klemetsdal G, Boman I. A missense mutation in growth differentiation factor 9 (GDF9) is strongly associated with litter size in sheep. BMC Genet. 2013;14:1 pubmed publisher
    ..1111A will produce minimum 0.46 - 0.57 additional lambs compared to daughters of wild-type rams...
  4. Mullen M, Hanrahan J, Howard D, Powell R. Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheep. PLoS ONE. 2013;8:e53172 pubmed publisher
    ..the likely origin of three mutations with large effects on ovulation rate identified in the Belclare and Cambridge sheep breeds; two in the BMP15 gene (FecX(G) and FecX(B)) and the third (FecG(H)) in GDF9...
  5. Demars J, Fabre S, Sarry J, Rossetti R, Gilbert H, Persani L, et al. Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyperprolificacy phenotype in sheep. PLoS Genet. 2013;9:e1003482 pubmed publisher
    Some sheep breeds are naturally prolific, and they are very informative for the studies of reproductive genetics and physiology...
  6. Drouilhet L, Mansanet C, Sarry J, Tabet K, Bardou P, Woloszyn F, et al. The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary. PLoS Genet. 2013;9:e1003809 pubmed publisher
    Prolific sheep have proven to be a valuable model to identify genes and mutations implicated in female fertility...
  7. Mikula I. Characterization of ovine Toll-like receptor 9 protein coding region, comparative analysis, detection of mutations and maedi visna infection. Dev Comp Immunol. 2011;35:182-92 pubmed publisher
    ..In this study, we characterized the protein coding region of ovine TLR9 gene...
  8. Goyal R, Mittal A, Chu N, Zhang L, Longo L. alpha(1)-Adrenergic receptor subtype function in fetal and adult cerebral arteries. Am J Physiol Heart Circ Physiol. 2010;298:H1797-806 pubmed publisher
    ..In CA from fetal ( approximately 140 days) and nonpregnant adult sheep, we used wire myography and imaging, with simultaneous measurement of tension and intracellular Ca(2+) ..
  9. Lyahyai J, Serrano C, Ranera B, Badiola J, Zaragoza P, Martin Burriel I. Effect of scrapie on the stability of housekeeping genes. Anim Biotechnol. 2010;21:1-13 pubmed publisher
    ..Gene expression analysis of normal and infected sheep may provide clues to clarify the molecular mechanisms involved in the neuropathology of these diseases...
  10. Garbayo J, Serrano B, Lopez Gatius F. Identification of novel pregnancy-associated glycoproteins (PAG) expressed by the peri-implantation conceptus of domestic ruminants. Anim Reprod Sci. 2008;103:120-34 pubmed
    ..Day 12, 14, 17 (ovine); day 15, 18 (bovine); and day 12, 14, 15, 16, 18 (caprine) conceptuses were used for reverse transcription-..
  11. Becker D, Tetens J, Brunner A, Bürstel D, Ganter M, Kijas J, et al. Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like homeodomain 3 (PITX3) gene. PLoS ONE. 2010;5:e8689 pubmed publisher
    ..For the first time, we use a genome-wide ovine SNP array for positional cloning of a Mendelian trait in sheep...
  12. Herman A, Tomaszewska Zaremba D. Effect of endotoxin on the expression of GnRH and GnRHR genes in the hypothalamus and anterior pituitary gland of anestrous ewes. Anim Reprod Sci. 2010;120:105-11 pubmed publisher
    ..This phenomenon could play an important role in the physiology of GnRH neurons. Our data demonstrate that immune stress could be important inhibitor of this process...
  13. Herman A, Misztal T, Herman A, Tomaszewska Zaremba D. Expression of interleukin (IL)-1? and IL-1 receptors genes in the hypothalamus of anoestrous ewes after lipopolysaccharide treatment. Reprod Domest Anim. 2010;45:e426-33 pubmed publisher
    ..Our results showed that IL-1? mRNA is transcribed in the ovine hypothalamus. Lipopolysaccharide increased (p???0.01) the IL-1? gene expression in the pre-optic area 2...
  14. Billings H, Connors J, Altman S, Hileman S, Holaskova I, Lehman M, et al. Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep. Endocrinology. 2010;151:3836-46 pubmed publisher
    ..Based on these data, and the effects of NK3R mutations in humans, we hypothesize that NKB plays an important stimulatory role in the control of GnRH and LH secretion in nonrodent species. ..
  15. Goldmann W, Houston F, Stewart P, Perucchini M, Foster J, Hunter N. Ovine prion protein variant A(136)R(154)L(168)Q(171) increases resistance to experimental challenge with bovine spongiform encephalopathy agent. J Gen Virol. 2006;87:3741-5 pubmed
    ..The standard model of association between ovine PrP genetics and classical scrapie susceptibility is based on PrP genotypes with respect to codons 136, 154 and ..
  16. Dupré S, Miedzinska K, Duval C, Yu L, Goodman R, Lincoln G, et al. Identification of Eya3 and TAC1 as long-day signals in the sheep pituitary. Curr Biol. 2010;20:829-35 pubmed publisher
    Seasonally breeding mammals such as sheep use photoperiod, encoded by the nocturnal secretion of the pineal hormone melatonin, as a critical cue to drive hormone rhythms and synchronize reproduction to the most optimal time of year...
  17. Silva B, Castro E, Souza C, Paiva S, Sartori R, Franco M, et al. A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increased ovulation rate and prolificacy in homozygous sheep. Anim Genet. 2011;42:89-92 pubmed publisher
    Brazilian Santa Inês (SI) sheep are very well-adapted to the tropical conditions of Brazil and are an important source of animal protein. A high rate of twin births was reported in some SI flocks...
  18. Boman I, Klemetsdal G, Blichfeldt T, Nafstad O, Vage D. A frameshift mutation in the coding region of the myostatin gene (MSTN) affects carcass conformation and fatness in Norwegian White Sheep (Ovis aries). Anim Genet. 2009;40:418-22 pubmed publisher
    ..In sheep, a mutation in the 3'-UTR region introducing a microRNA target site has been reported to cause an IMM-like ..
  19. Reina R, Glaria I, Benavides J, de Andrés X, Crespo H, Solano C, et al. Association of CD80 and CD86 expression levels with disease status of Visna/Maedi virus infected sheep. Viral Immunol. 2007;20:609-22 pubmed
    ..molecules B7-1 and B7-2 are involved in infections with Visna/Maedi virus (VMV), the prototype lentivirus of sheep. We studied B7 expression levels ex vivo in peripheral blood mononuclear cells (PBMCs), determining B7 RNA levels ..
  20. Marcos Carcavilla A, Mutikainen M, Gonzalez C, Calvo J, Kantanen J, Sanz A, et al. A SNP in the HSP90AA1 gene 5' flanking region is associated with the adaptation to differential thermal conditions in the ovine species. Cell Stress Chaperones. 2010;15:67-81 pubmed publisher
    ..polymorphisms in the gene encoding the inducible form of the cytoplasmic Hsp90 (HSP90AA1) were addressed in 24 sheep breeds reared in different climatic regions of Europe, Africa, and Asia...
  21. French A, Knight P, Smith W, Brown J, Craig N, Pate J, et al. Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta. Int J Parasitol. 2008;38:467-75 pubmed
    A novel intelectin molecule designated sheep intelectin 2 (sITLN2) was detected in sheep abomasal mucosa. The full sequence shared 76-83% homology with other mammalian intelectins...
  22. Lampo E, Van Poucke M, Vandesompele J, Erkens T, Van Zeveren A, Peelman L. Positive correlation between relative mRNA expression of PRNP and SPRN in cerebral and cerebellar cortex of sheep. Mol Cell Probes. 2009;23:60-4 pubmed publisher
    ..this study, we investigated by quantitative real-time PCR the relative mRNA expression levels of SPRN and PRNP in sheep cerebrum and cerebellum and the mutual relationship between these expression levels...
  23. Kumar S, Sud N, Fonseca F, Hou Y, Black S. Shear stress stimulates nitric oxide signaling in pulmonary arterial endothelial cells via a reduction in catalase activity: role of protein kinase C delta. Am J Physiol Lung Cell Mol Physiol. 2010;298:L105-16 pubmed publisher
  24. Ushizawa K, Takahashi T, Hosoe M, Ohkoshi K, Hashizume K. Expression and characterization of novel ovine orthologs of bovine placental prolactin-related proteins. BMC Mol Biol. 2007;8:95 pubmed
    ..We investigated placental PRP in sheep in order to gain a comprehensive understanding of the function and evolution of these molecules...
  25. Beraldi D, McRae A, Gratten J, Slate J, Visscher P, Pemberton J. Development of a linkage map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep (Ovis aries). Genetics. 2006;173:1521-37 pubmed
    ..Horn type maps to chromosome 10, a location similar to that previously identified in domestic sheep. These findings represent an advance in the dissection of the genetic diversity in the wild and provide the ..
  26. Lysek D, Schorn C, Nivon L, Esteve Moya V, Christen B, Calzolai L, et al. Prion protein NMR structures of cats, dogs, pigs, and sheep. Proc Natl Acad Sci U S A. 2005;102:640-5 pubmed publisher
    ..dog (Canis familiaris), and pig (Sus scrofa), and of two polymorphic forms of the prion protein from sheep (Ovis aries) are presented...
  27. Lan Z, Wang Z, Liu Y, Zhang X. Prion protein gene (PRNP) polymorphisms in Xinjiang local sheep breeds in China. Arch Virol. 2006;151:2095-101 pubmed
    ..those occurring at codons 136, 154, and 171 have a significant influence on scrapie pathogenesis in many sheep breeds...
  28. Jónsson S, Haché G, Stenglein M, Fahrenkrug S, Andresdottir V, Harris R. Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins. Nucleic Acids Res. 2006;34:5683-94 pubmed
    ..Here, we report an APOBEC3F-like, double deaminase domain protein from three artiodactyls: cattle, pigs and sheep. Like their human counterparts, APOBEC3F and APOBEC3G, the artiodactyl APOBEC3F proteins are DNA cytosine ..
  29. Premzl M, Gamulin V. Comparative genomic analysis of prion genes. BMC Genomics. 2007;8:1 pubmed publisher
    ..It is likely that the conserved genomic elements identified in this analysis represent bona fide cis-elements. However, this idea needs to be confirmed by functional assays in transgenic systems...
  30. Marcos Carcavilla A, Calvo J, Gonzalez C, Moazami Goudarzi K, Laurent P, Bertaud M, et al. Structural and functional analysis of the HSP90AA1 gene: distribution of polymorphisms among sheep with different responses to scrapie. Cell Stress Chaperones. 2008;13:19-29 pubmed publisher
    Scrapie is a transmissible spongiform encephalopathy in sheep and goats. Susceptibility to this neurodegenerative disease is mainly controlled by point mutations at the PRNP locus...
  31. Purcell S, Cantlon J, Wright C, Henkes L, Seidel G, Anthony R. The involvement of proline-rich 15 in early conceptus development in sheep. Biol Reprod. 2009;81:1112-21 pubmed publisher
    ..The purpose of these studies was to investigate the role of proline-rich 15 (PRR15) in the sheep conceptus by examining mRNA expression, protein localization, and the effect of PRR15 mRNA degradation...
  32. Tian J, Smith A, Nechtman J, Podolsky R, Aggarwal S, Snead C, et al. Effect of PPARgamma inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension. Physiol Genomics. 2009;40:48-60 pubmed publisher
    ..of PPARgamma and the upregulation of HMMR, Flk-1, FGF2, and Cav-1 proteins in the peripheral lung tissues of an ovine model of PH...
  33. Hadjipavlou G, Matika O, Clop A, Bishop S. Two single nucleotide polymorphisms in the myostatin (GDF8) gene have significant association with muscle depth of commercial Charollais sheep. Anim Genet. 2008;39:346-53 pubmed publisher
    ..Mixed model association analyses using SNP data on 338 Charollais lambs from 17 paternal half-sib families and phenotype and pedigree data on 56 500 lambs revealed that both SNPs had a ..
  34. Ecroyd H, Sarradin P, Dacheux J, Gatti J. Compartmentalization of prion isoforms within the reproductive tract of the ram. Biol Reprod. 2004;71:993-1001 pubmed
    ..In sperm, this C-terminal truncated form was found to be associated with membrane lipid rafts present in the mature sperm, suggesting a role for it in the terminal stages of sperm maturation. ..
  35. Herrmann Hoesing L, White S, Mousel M, Lewis G, Knowles D. Ovine progressive pneumonia provirus levels associate with breed and Ovar-DRB1. Immunogenetics. 2008;60:749-58 pubmed publisher
    ..of OPPV as measured by provirus levels in the peripheral blood associates with certain breeds and MHC class II Ovis aries (Ovar)-DRB1 expressed alleles...
  36. Murphy S, Freking B, Smith T, Leymaster K, Nolan C, Wylie A, et al. Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep. Mamm Genome. 2005;16:171-83 pubmed
    The underlying mechanism of the callipyge muscular hypertrophy phenotype in sheep (Ovis aries) is not presently understood...
  37. Marcos Carcavilla A, Moreno C, Serrano M, Laurent P, Cribiu E, Andreoletti O, et al. Polymorphisms in the HSP90AA1 5' flanking region are associated with scrapie incubation period in sheep. Cell Stress Chaperones. 2010;15:343-9 pubmed publisher
    ..Here, we have analyzed several polymorphisms which were previously described in the ovine HSP90AA1 5' flanking region and in intron 10 in two naturally scrapie infected Romanov sheep populations...
  38. Garcia Crespo D, Juste R, Hurtado A. Selection of ovine housekeeping genes for normalisation by real-time RT-PCR; analysis of PrP gene expression and genetic susceptibility to scrapie. BMC Vet Res. 2005;1:3 pubmed
    ..between PrP gene expression and genetic susceptibility, PrP mRNA levels were measured by real-time RT-PCR in six ovine tissues of animals with different genotypes...
  39. Herrmann L, Brown W, Lewis G, Knowles D. Identification and phylogenetic analysis of 15 MHC class II DRB1 beta1 expressed alleles in a ewe-lamb flock. Immunogenetics. 2005;57:855-63 pubmed
    Ovar-DRB1 is part of the major histocompatibility complex (MHC) class II of sheep and functions by presenting extracellular-derived peptides to the immune system...
  40. Beever J, Smit M, Meyers S, Hadfield T, Bottema C, Albretsen J, et al. A single-base change in the tyrosine kinase II domain of ovine FGFR3 causes hereditary chondrodysplasia in sheep. Anim Genet. 2006;37:66-71 pubmed
    b>Ovine hereditary chondrodysplasia, or spider lamb syndrome (SLS), is a genetic disorder that is characterized by severe skeletal abnormalities and has resulted in substantial economic losses for sheep producers...
  41. Martinez Royo A, Jurado J, Smulders J, Marti J, Alabart J, Roche A, et al. A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in Rasa Aragonesa sheep. Anim Genet. 2008;39:294-7 pubmed publisher
    ..of the transforming growth factor beta superfamily, is specifically expressed in oocytes and is essential for sheep prolificacy...
  42. Nezamzadeh R, Seubert A, Pohlenz J, Brenig B. Identification of a mutation in the ovine uroporphyrinogen decarboxylase (UROD) gene associated with a type of porphyria. Anim Genet. 2005;36:297-302 pubmed
    ..To investigate this, we cloned and sequenced the ovine UROD gene...
  43. Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison S, et al. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005;438:633-8 pubmed
    ..We were therefore able to build an atomic model for the lipid bilayer surrounding the AQP0 tetramers, and we describe lipid-protein interactions. ..
  44. Murphy S, Nolan C, Huang Z, Kucera K, Freking B, Smith T, et al. Callipyge mutation affects gene expression in cis: a potential role for chromatin structure. Genome Res. 2006;16:340-6 pubmed
    Muscular hypertrophy in callipyge sheep results from a single nucleotide substitution located in the genomic interval between the imprinted Delta, Drosophila, Homolog-like 1 (DLK1) and Maternally Expressed Gene 3 (MEG3)...
  45. Keane O, Dodds K, Crawford A, McEwan J. Transcriptional profiling of Ovis aries identifies Ovar-DQA1 allele frequency differences between nematode-resistant and susceptible selection lines. Physiol Genomics. 2007;30:253-61 pubmed
    ..Transcription profiles were taken at three time points during the growth of lambs. The number of genes differentially expressed increased as animals were exposed to longer nematode challenge...
  46. White S, Mousel M, Reynolds J, Lewis G, Herrmann Hoesing L. Common promoter deletion is associated with 3.9-fold differential transcription of ovine CCR5 and reduced proviral level of ovine progressive pneumonia virus. Anim Genet. 2009;40:583-9 pubmed publisher
    ..Both ovine progressive pneumonia virus (OPPV), also known as maedi-visna, and HIV are macrophage-tropic lentiviruses, have ..
  47. Alvarez L, Arranz J, San Primitivo F. Identification of a new leucine haplotype (ALQ) at codon 154 in the ovine prion protein gene in Spanish sheep. J Anim Sci. 2006;84:259-65 pubmed
    ..In this paper, we describe the method used with 2 Spanish dairy sheep breeds (Churra and Castellana) to ascertain the initial status of protection against scrapie as a first step ..
  48. Bodin L, Di Pasquale E, Fabre S, Bontoux M, Monget P, Persani L, et al. A novel mutation in the bone morphogenetic protein 15 gene causing defective protein secretion is associated with both increased ovulation rate and sterility in Lacaune sheep. Endocrinology. 2007;148:393-400 pubmed
    Genetic mutations with major effects on ovulation rate and litter size in sheep were recently identified in three genes belonging to the TGFbeta superfamily pathway: the bone morphogenetic protein 15 (BMP15, also known as GDF9b), growth ..
  49. Schaub C, Keller Wood M, Wood C. Blockade of estrogen receptors decreases CNS and pituitary prostaglandin synthase expression in fetal sheep. Neuroendocrinology. 2008;87:121-8 pubmed
    ..Blockade of CNS estrogen receptors reduces preparturient plasma concentrations of POMC, but does not reduce fetal HPA axis activity in 130-134 day fetal sheep.
  50. Bebbere D, Bogliolo L, Ariu F, Fois S, Leoni G, Tore S, et al. Expression pattern of zygote arrest 1 (ZAR1), maternal antigen that embryo requires (MATER), growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) genes in ovine oocytes and in vitro-produced preimplantation embryos. Reprod Fertil Dev. 2008;20:908-15 pubmed
    ..MATER), growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15), were determined in ovine oocytes and in vitro-produced preimplantation embryos...
  51. Billinis C, Psychas V, Leontides L, Spyrou V, Argyroudis S, Vlemmas I, et al. Prion protein gene polymorphisms in healthy and scrapie-affected sheep in Greece. J Gen Virol. 2004;85:547-54 pubmed
    A total of 216 local crossbred sheep from 16 scrapie-affected Greek flocks and 210 purebred sheep of the milk breeds Chios and Karagouniko from healthy flocks were analysed for scrapie-linked polymorphisms in the prion protein (PrP) gene...
  52. Haire L, Whyte S, Vasisht N, Gill A, Verma C, Dodson E, et al. The crystal structure of the globular domain of sheep prion protein. J Mol Biol. 2004;336:1175-83 pubmed
    ..crystal structure, at 2 A resolution, of residues 123-230 of the C-terminal globular domain of the ARQ allele of sheep prion protein (PrP)...
  53. Gonen T, Sliz P, Kistler J, Cheng Y, Walz T. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 2004;429:193-7 pubmed
    ..The water pathway in AQP0 also contains an additional pore constriction, not seen in other known aquaporin structures, which may be responsible for pore gating. ..
  54. Chu M, Liu Z, Jiao C, He Y, Fang L, Ye S, et al. Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries). J Anim Sci. 2007;85:598-603 pubmed
    The Small Tailed Han is a prolific local sheep breed in China...
  55. Nicol L, Bishop S, Pong Wong R, Bendixen C, Holm L, Rhind S, et al. Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheep. Reproduction. 2009;138:921-33 pubmed publisher
    ..Previously, several mutations have been identified in sheep which increase the naturally low ovulation rate; although in some cases homozygous ewes are infertile...
  56. Smith J, Li Q, Pereira A, Clarke I. Kisspeptin neurons in the ovine arcuate nucleus and preoptic area are involved in the preovulatory luteinizing hormone surge. Endocrinology. 2009;150:5530-8 pubmed publisher
    Kisspeptin is the product of the Kiss1 gene that regulates GnRH secretion. In sheep, Kiss1 mRNA-expressing cells are found in the preoptic area (POA) and arcuate nucleus (ARC), and expression is up-regulated in the caudal ARC during the ..
  57. Tsoi S, Wen Y, Chung J, Chen D, Magness R, Zheng J. Co-expression of vascular endothelial growth factor and neuropilin-1 in ovine feto-placental artery endothelial cells. Mol Cell Endocrinol. 2002;196:95-106 pubmed
    ..To evaluate the role of VEGF and NP-1 in regulating fetoplacental angiogenesis and endothelial function, an ovine fetal placental artery endothelial (OFPAE) cell line was established...
  58. Georges M, Charlier C, Cockett N. The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes. Trends Genet. 2003;19:248-52 pubmed
    The callipyge phenotype in sheep is an inherited muscular hypertrophy that affects only heterozygous individuals who receive the CLPG mutation from their father...
  59. Våge D, Fleet M, Ponz R, Olsen R, Monteagudo L, Tejedor M, et al. Mapping and characterization of the dominant black colour locus in sheep. Pigment Cell Res. 2003;16:693-7 pubmed
    Dominant black pigment synthesis in sheep is caused by alterations of the melanocortin-1 receptor (MC1-R) coding sequence...
  60. Eghiaian F, Grosclaude J, Lesceu S, Debey P, Doublet B, Treguer E, et al. Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants. Proc Natl Acad Sci U S A. 2004;101:10254-9 pubmed
    ..We report here the 2.5-A-resolution crystal structures of three scrapie-susceptibility ovine PrP variants complexed with an antibody that binds to PrPC and to PrPSc; they identify two important features of ..
  61. Davis E, Jensen C, Schroder H, Farnir F, Shay Hadfield T, Kliem A, et al. Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype. Curr Biol. 2004;14:1858-62 pubmed
    The callipyge (CLPG) phenotype is an inherited skeletal muscle hypertrophy described in sheep. It is characterized by an unusual mode of inheritance ("polar overdominance") in which only heterozygous individuals having received ..
  62. Espenes A, Harbitz I, Skogtvedt S, Fuglestveit R, Berg K, Dick G, et al. Dynamic expression of the prion-like protein Doppel in ovine testicular tissue. Int J Androl. 2006;29:400-8 pubmed
    ..We have investigated the expression pattern and some biochemical properties of Dpl in sheep testicular tissue and spermatozoa. Neither the Dpl protein nor its mRNA was detected in pre-pubertal sheep testis...
  63. Guan F, Liu S, Shi G, Yang L. Polymorphism of FecB gene in nine sheep breeds or strains and its effects on litter size, lamb growth and development. Anim Reprod Sci. 2007;99:44-52 pubmed
    Nine sheep breeds or strains, including 615 individuals were screened with forced PCR RFLP method for the FecB gene to study the polymorphism and its effects on litter sizes, body weights and body sizes...
  64. Smith J, Clay C, Caraty A, Clarke I. KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Endocrinology. 2007;148:1150-7 pubmed
    ..Furthermore, a seasonal alteration in KiSS-1 expression in the ARC of OVX ewes strongly suggests that kisspeptin is fundamentally involved in the control of seasonal changes in reproductive function. ..
  65. Itenge Mweza T, Forrest R, McKenzie G, Hogan A, Abbott J, Amoafo O, et al. Polymorphism of the KAP1.1, KAP1.3 and K33 genes in Merino sheep. Mol Cell Probes. 2007;21:338-42 pubmed
    ..This study used 1541 Merino lambs born to 40 sires sourced from three farms in the South Island of New Zealand...
  66. Goodman R, Lehman M, Smith J, Coolen L, de Oliveira C, Jafarzadehshirazi M, et al. Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology. 2007;148:5752-60 pubmed
    ..Because virtually all of these neurons express estrogen and progesterone re-ceptors, they are likely to relay the feedback effects of these steroids to GnRH neurons to regulate reproductive function. ..
  67. Frugier T, Mitchell N, Tammen I, Houweling P, Arthur D, Kay G, et al. A new large animal model of CLN5 neuronal ceroid lipofuscinosis in Borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>A) leading to excision of exon 3. Neurobiol Dis. 2008;29:306-15 pubmed
    ..Linkage analysis indicated a CLN5 form in a colony of affected New Zealand Borderdale sheep. Sequencing studies established the disease-causing mutation to be a substitution at a consensus splice site (c...
  68. Jeffrey M, McGovern G, Goodsir C, Sisó S, Gonzalez L. Strain-associated variations in abnormal PrP trafficking of sheep scrapie. Brain Pathol. 2009;19:1-11 pubmed publisher
    ..We show here that different light microscopic types of abnormal PrP (PrP(d)) accumulation found in each of 10 sheep scrapie cases correspond ultrastructurally with abnormal endocytosis, increased endo-lysosomes, microfolding of ..
  69. Smith J, Coolen L, Kriegsfeld L, Sari I, Jaafarzadehshirazi M, Maltby M, et al. Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology. 2008;149:5770-82 pubmed publisher
    Reproductive activity in sheep is seasonal, being activated by short-day photoperiods and inhibited by long days...
  70. Lincoln G, Messager S, Andersson H, Hazlerigg D. Temporal expression of seven clock genes in the suprachiasmatic nucleus and the pars tuberalis of the sheep: evidence for an internal coincidence timer. Proc Natl Acad Sci U S A. 2002;99:13890-5 pubmed
    ..All clock genes were expressed in the ovine SCN and PT...
  71. Fleming J, Yu F, McDonald R, Meyers S, Montgomery G, Smith J, et al. Effects of scrotal heating on sperm surface protein PH-20 expression in sheep. Mol Reprod Dev. 2004;68:103-14 pubmed
    ..A 282 nt cDNA fragment of ovine PH-20 was identified in total RNA extracts of sheep testes, which exhibited 76% identity at the nucleotide level ..
  72. Song G, Bazer F, Wagner G, Spencer T. Stanniocalcin (STC) in the endometrial glands of the ovine uterus: regulation by progesterone and placental hormones. Biol Reprod. 2006;74:913-22 pubmed
    ..These studies determined the effects of pregnancy and related hormones on STC expression in the ovine uterus. In Days 10-16 cyclic and pregnant ewes, STC1 mRNA was not detected in the uterus...
  73. Chakrabarty A, Green J, Roberts R. Origin and evolution of the TKDP gene family. Gene. 2006;373:35-43 pubmed
    ..We isolated, mapped and fully sequenced the ovine (ov) TKDP-1 gene...
  74. Grobe A, Wells S, Benavidez E, Oishi P, Azakie A, Fineman J, et al. Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase. Am J Physiol Lung Cell Mol Physiol. 2006;290:L1069-77 pubmed
    ..Our previous studies, using isolated pulmonary arteries taken from lambs with surgically created heart defect and increased pulmonary blood flow (Shunt), have suggested a role for ..
  75. Ushizawa K, Takahashi T, Hosoe M, Kizaki K, Abe Y, Sasada H, et al. Gene expression profiles of novel caprine placental prolactin-related proteins similar to bovine placental prolactin-related proteins. BMC Dev Biol. 2007;7:16 pubmed
    ..The data indicate that PRP genes in caprine placenta have coordination functions for gestation, as they do in bovine. This is the first study of PRPs function in caprine placenta. ..
  76. Su P, Shafiee Kermani F, Gore A, Jia J, Wu J, Miller W. Expression and regulation of the beta-subunit of ovine follicle-stimulating hormone relies heavily on a promoter sequence likely to bind Smad-associated proteins. Endocrinology. 2007;148:4500-8 pubmed
    ..Studies with ovine FSHB promoter/reporter constructs in L beta T2 gonadotropes show that induction by activin requires a putative ..
  77. Sud N, Sharma S, Wiseman D, Harmon C, Kumar S, Venema R, et al. Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1444-53 pubmed
    Previously, we have shown that pulmonary arterial endothelial cells (PAECs) isolated from fetal lambs produce significant levels of nitric oxide (NO) but minimal superoxide upon stimulation, whereas PAECs isolated from 4-wk-old lambs ..
  78. Fitzmaurice T, Burke D, Hopkins L, Yang S, Yu S, Sy M, et al. The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2. Biochem J. 2008;409:367-75 pubmed
    Susceptibility to scrapie disease in sheep, the archetypal prion disease, correlates with polymorphisms within the ovine PrP (prion-related protein) gene...
  79. Wood C. Cerebral hypoperfusion increases estrogen receptor abundance in the ovine fetal brain and pituitary. Neuroendocrinology. 2008;87:216-22 pubmed
    Estrogen is an important component of fetal neuroendocrine function in late-gestation fetal sheep; however, little is known about the regulation of estrogen receptor abundance in the brain and pituitary of fetuses...
  80. Wang Y, Qin Z, Qiao J, Zhao D. Polymorphisms of the prion protein gene in sheep of Inner Mongolia, China. Virus Genes. 2008;37:128-30 pubmed publisher
    ..of the prion protein gene (Prnp), especially the amino acid residue alterations at codons 136, 154, and 174, in sheep have been found to be associated with susceptibility to scrapie disease...
  81. Dupré S, Burt D, Talbot R, Downing A, Mouzaki D, Waddington D, et al. Identification of melatonin-regulated genes in the ovine pituitary pars tuberalis, a target site for seasonal hormone control. Endocrinology. 2008;149:5527-39 pubmed publisher
    ..photoperiod-transduction mechanism, we performed a whole genome transcriptome analysis using PT RNA isolated from sheep culled at three time points over the 24-h cycle under either long or short photoperiods...
  82. Oishi P, Wiseman D, Sharma S, Kumar S, Hou Y, Datar S, et al. Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress. Am J Physiol Lung Cell Mol Physiol. 2008;295:L756-66 pubmed publisher
    ..An 8-mm graft (shunt) was placed between the aorta and pulmonary artery in 30 late gestation fetal lambs; 27 fetal lambs underwent a sham procedure...
  83. Chu M, Wang X, Jin M, Di R, Chen H, Zhu G, et al. DNA polymorphism of 5' flanking region of prolactin gene and its association with litter size in sheep. J Anim Breed Genet. 2009;126:63-8 pubmed publisher
    ..The Small Tail Han ewes with AB genotype had 0.83 (p < 0.05) lambs more than those with AA genotype...
  84. Johnson G, Burghardt R, Joyce M, Spencer T, Bazer F, Gray C, et al. Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy. Biol Reprod. 2003;69:92-8 pubmed
    ..In sheep and humans, OPN is proposed to be a secretory product of uterine glandular epithelium (GE) that binds to uterine ..
  85. Nagaoka K, Sakai A, Nojima H, Suda Y, Yokomizo Y, Imakawa K, et al. A chemokine, interferon (IFN)-gamma-inducible protein 10 kDa, is stimulated by IFN-tau and recruits immune cells in the ovine endometrium. Biol Reprod. 2003;68:1413-21 pubmed
    ..These results suggest that endometrial IP-10 regulated by conceptus IFN-tau regulates recruitment and/or distribution of immune cells seen in the early pregnant uterus. ..
  86. Byers M, Zangl A, Phernetton T, Lopez G, Chen D, Magness R. Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levels. J Physiol. 2005;565:85-99 pubmed
    ..Compared to luteal phase sheep, both ERalpha and ERbeta levels in UAendo were elevated in follicular phase sheep...
  87. Dukarm R, Steinhorn R, Russell J, Lakshminrusimha S, Swartz D, Cummings J. Selective type 5 phosphodiesterase inhibition alters pulmonary hemodynamics and lung liquid production in near-term fetal lambs. J Appl Physiol (1985). 2005;99:2331-6 pubmed
    ..of a specific phosphodiesterase inhibitor, E4021, on pulmonary arteries and veins isolated from near-term fetal lambs, as well as in intact, chronically instrumented late-gestation fetal lambs...
  88. Estrada K, Clay C, Pompolo S, Smith J, Clarke I. Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback. J Neuroendocrinol. 2006;18:806-9 pubmed
    ..Here, we quantify gene expression of KiSS-1 in the arcuate nucleus (ARC) across the ovine oestrous cycle and demonstrate an increase in the caudal division of the ARC during the preovulatory period...
  89. Perkins A, Kramer L, Spurlock D, Hadfield T, Cockett N, Bidwell C. Postnatal changes in the expression of genes located in the callipyge region in sheep skeletal muscle. Anim Genet. 2006;37:535-42 pubmed
    The expression of five genes surrounding the callipyge (CLPG) mutation was analysed in skeletal muscles from lambs at one prenatal and two postnatal ages that coincide with the onset and establishment of muscle hypertrophy...
  90. White J, Vuocolo T, McDonagh M, Grounds M, Harper G, Cockett N, et al. Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cells. Differentiation. 2008;76:283-98 pubmed
    The callipyge mutation in sheep in the form of the paternal heterozygote results in skeletal muscle hypertrophy, which is most pronounced in the hindquarters...
  91. Oswald M, Palmer D, Kay G, Barwell K, Cooper J. Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis. Neurobiol Dis. 2008;32:50-65 pubmed publisher
    The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are fatal inherited neurodegenerative diseases. Sheep affected with the CLN6 form provide a valuable model to investigate underlying disease mechanisms from preclinical stages...
  92. Fustin J, O Neill J, Hastings M, Hazlerigg D, Dardente H. Cry1 circadian phase in vitro: wrapped up with an E-box. J Biol Rhythms. 2009;24:16-24 pubmed publisher