Alias: Neandertal man, Neanderthal, Neanderthal man, Homo sapiens neanderthalensis, Homo neanderthalensis

Top Publications

  1. Kirkman M, Yu Wai Man P, Korsten A, Leonhardt M, Dimitriadis K, de Coo I, et al. Gene-environment interactions in Leber hereditary optic neuropathy. Brain. 2009;132:2317-26 pubmed publisher
    ..Based on these findings, asymptomatic carriers of a LHON mtDNA mutation should be strongly advised not to smoke and to moderate their alcohol intake. ..
  2. Xia S, Zhao Y, Yu S, Zhang M. Activated PI3K/Akt/COX-2 pathway induces resistance to radiation in human cervical cancer HeLa cells. Cancer Biother Radiopharm. 2010;25:317-23 pubmed publisher
    ..This study proposes that the inhibition of the PI3K/Akt/COX-2 pathway can synergistically enhance radiation efficacy...
  3. Xu Y, Zhao B, Long C, Li H, Lu X, Liu G, et al. Cyclooxygenase-2 promoter 765C increase of digestive tract cancer risk in the Chinese population: a meta-analysis. Asian Pac J Cancer Prev. 2014;15:4563-6 pubmed
    ..No significant liver cancer and colorectal cancer risk of COX-2 -765G/C polymorphism was found. These findings suggest that COX-2-765*C is related to cancer susceptibility and may increase gastric and pancreatic cancer risk. ..
  4. Zeng L, Zhen Y, Chen Y, Zou L, Zhang Y, Hu F, et al. Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF‑κB/COX‑2‑caspase-1 pathway in HeLa cervical cancer cells. Int J Oncol. 2014;45:1929-36 pubmed publisher
  5. Hua H, Jin C, Yang L, Tao S, Zhu X. Expression of Cyclooxygenase-2 in Squamous Cell Carcinoma and Keratoacanthoma and its Clinical Significance. Cell Biochem Biophys. 2015;72:475-80 pubmed publisher
    ..The positive expression rate of COX-2 is associated with the malignant degree of the tumor, and also it may help differentiating squamous cell carcinoma from keratoacanthoma. ..
  6. Wu Y, Chen X, Chai J. The involvement of the CD40-CD40L pathway in activated platelet-induced changes in HUVEC COX-2 and PPAR? expression. Inflammation. 2012;35:1184-90 pubmed publisher
    ..01) increased COX-2 enzymatic activity, but had almost no effects on PPAR? binding activity. Activated platelets may increase HUVEC COX-2 expression and activity partly through the CD40-CD40L pathway. ..
  7. Lee S, Kim H, Roh K, Lee B, Shin T, Yoo J, et al. DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells. Sci Rep. 2015;5:8020 pubmed publisher
    ..Moreover, using an experimental colitis model, we showed that 5-aza pre-treatment could enhance the therapeutic effect of MSCs against immune-related diseases. ..
  8. Qiu Z, Qiu Z. Sensitivity of gastric cancer cells to chemotherapy drugs in elderly patients and its correlation with cyclooxygenase-2 expression. Asian Pac J Cancer Prev. 2015;16:3447-50 pubmed
    ..915, P=0.000; r=-0.890, P=0.000; r=-0.949, P=0.000). Gastric cancer cells in elderly patients feature stronger MDR, which may be related to high COX-2 expression. ..
  9. Yi X, Cheng W, Lin J, Zhou Q, Wang C. Interaction between COX-1 and COX-2 Variants Associated with Aspirin Resistance in Chinese Stroke Patients. J Stroke Cerebrovasc Dis. 2016;25:2136-44 pubmed publisher
    ..The interactions of rs3842787 and rs20417 were associated with AR. The combinational analysis used in this study may provide further insight into the complex genetic risk of AR. ..

More Information

Publications152 found, 100 shown here

  1. Chene G, Tardieu A, Trombert B, Amouzougan A, Lamblin G, Mellier G, et al. A species' Odyssey: evolution of obstetrical mechanics from Australopithecus Lucy to nowadays. Eur J Obstet Gynecol Reprod Biol. 2014;181:316-20 pubmed publisher
    Study of obstetrical mechanics of Australopithecus Lucy, Homo neanderthalensis and Homo erectus relative to modern Homo sapiens and the Catarrhines...
  2. Bisaro B, Montani M, Konstantinidou G, Marchini C, Pietrella L, Iezzi M, et al. p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast Cancer Res. 2012;14:R137 pubmed publisher
    ..Overall, these data identify a new p130Cas/Cyclooxygenase-2 axis as a crucial element in the control of breast tumor plasticity, opening new therapeutic strategies leading to inhibition of these pathways in aggressive breast carcinoma. ..
  3. Krawczyk M, Emerson B. p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-?B complexes. elife. 2014;3:e01776 pubmed publisher
    ..DOI: ..
  4. Li N, Li H, Su F, Li J, Ma X, Gong P. Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 Level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells. Int J Clin Exp Pathol. 2015;8:9010-20 pubmed
  5. Kato T, Nishigaki Y, Noguchi Y, Ueno H, Hosoya H, Ito T, et al. Extensive and rapid screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss. J Hum Genet. 2010;55:147-54 pubmed publisher
    ..11778G>A in the MT-ND4 gene and 15498G>A in the MT-CYB gene were detected in one patient for each. This screening system is useful for the genetic diagnosis and epidemiological study of both syndromic and non-syndromic HL...
  6. Kokotas H, Grigoriadou M, Korres G, Ferekidou E, Kandiloros D, Korres S, et al. Screening of a Greek deafness population for the A7445G mitochondrial DNA mutation. Mol Genet Metab. 2010;100:300-1 pubmed publisher
  7. Liu S, Zhang C, Zhang K, Gao Y, Wang Z, Li X, et al. FOXP3 inhibits cancer stem cell self-renewal via transcriptional repression of COX2 in colorectal cancer cells. Oncotarget. 2017;8:44694-44704 pubmed publisher
    ..Taken together, we here revealed possible involvement of FOXP3 in regulating cCSC self-renewal via tuning COX2 expression, and thus providing a new target for the eradication of colon cancer stem cells. ..
  8. He T, Wang Y, Xiang J, Zhang H. In vivo tracking of novel SPIO-Molday ION rhodamine-B™-labeled human bone marrow-derived mesenchymal stem cells after lentivirus- mediated COX-2 silencing: a preliminary study. Curr Gene Ther. 2014;14:136-45 pubmed
    ..The MIRB-labeled lenti-shCOX2 hBMSCs transplanted into nude rat models via tail vein injection can be detected and monitored in vivo using 3.0 T clinical MRI for up to 14 days after cell transplantation. ..
  9. Qu J, Zhou X, Zhao F, Liu X, Zhang M, Sun Y, et al. Low penetrance of Leber's hereditary optic neuropathy in ten Han Chinese families carrying the ND6 T11484C mutation. Biochim Biophys Acta. 2010;1800:305-12 pubmed publisher
    ..However, nuclear modifier genes and environmental factors appear to be modifier factors for the phenotypic manifestation of the T14484C mutation in these Chinese families. ..
  10. Wang X, Chen Y, Zhang S, Zhang L, Liu X, Zhang L, et al. Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis. J Neurooncol. 2015;125:277-85 pubmed publisher
    ..These results suggest that COX-2 and 5-LO play roles in tumorigenesis and the progression of primary glioblastoma and that the co-expression pattern of COX-2/5-LO may be used as an independent prognostic factor in this disease. ..
  11. Stylos E, Chatziathanasiadou M, Tsiailanis A, Kellici T, Tsoumani M, Kostagianni A, et al. Tailoring naringenin conjugates with amplified and triple antiplatelet activity profile: Rational design, synthesis, human plasma stability and in vitro evaluation. Biochim Biophys Acta. 2017;1861:2609-2618 pubmed publisher
    ..Natural products could offer a rich source for novel bioactives as a powerful alternative to the current combinatorial use of three different antiplatelet drugs. ..
  12. Yang J, Zhu Y, Tong Y, Chen L, Liu L, Zhang Z, et al. Confirmation of the mitochondrial ND1 gene mutation G3635A as a primary LHON mutation. Biochem Biophys Res Commun. 2009;386:50-4 pubmed publisher
    ..In summary, the G3635A mutation is confirmed as a rare primary pathogenic mutation for LHON...
  13. Zhang Q, Qiu J, Li H, Lu Y, Wang X, Yang J, et al. Cyclooxygenase 2 promotes parathyroid hyperplasia in ESRD. J Am Soc Nephrol. 2011;22:664-72 pubmed publisher
    ..In conclusion, COX2 promotes the pathogenesis of hyperparathyroidism in ESRD, suggesting that inhibiting the COX2 pathway could be a potential therapeutic target. ..
  14. Meng X, Zhu J, Gao M, Zhang S, Zhao F, Zhang J, et al. [The analysis of mitochondrial DNA haplogroups and variants for Leber's hereditary optic neuropathy in Chinese families carrying the m.14484T >C mutation]. Yi Chuan. 2014;36:336-45 pubmed
    ..These observations indicated that mitochondrial haplogroup M10a may increase the risk of visual loss. ..
  15. Yuan Y, Wang W, Li H, Yu Y, Tao J, Huang S, et al. Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma. BMC Cancer. 2015;15:346 pubmed publisher
    ..Our data suggest that mitND6 gene nonsense and missense mutation might promote cell migration and invasion in lung adenocarcinoma, probably by NADH dehydrogenase deficiency induced over-production of ROS. ..
  16. Wang W, Fan X, Zhang Y, Yang Y, Yang S, Li G. Association Between COX-2 Polymorphisms and Lung Cancer Risk. Med Sci Monit. 2015;21:3740-7 pubmed
    ..CONCLUSIONS In COX-2 gene, rs20417 may have a certain relationship with reduced risk of lung cancer, while rs2066826 may increase the risk of lung cancer. ..
  17. Xiao D, Bae C, Shen G, Delson E, Jin J, Webb N, et al. Metric and geometric morphometric analysis of new hominin fossils from Maba (Guangdong, China). J Hum Evol. 2014;74:1-20 pubmed publisher
    ..closely with modern humans, though the minimum spanning tree from the 2D GM analysis also connects Maba to Homo neanderthalensis. The patterning in the M2s is not as clear as with the M1s...
  18. Oliveira Filho J, Ornellas A, Zhang C, Oliveira L, Araújo Santos T, Borges V, et al. COX-2 rs20417 Polymorphism Is Associated with Stroke and White Matter Disease. J Stroke Cerebrovasc Dis. 2015;24:1817-22 pubmed publisher
    ..037), but not among cardioembolic stroke patients. Variation in COX-2 gene is associated with both symptomatic and silent brain cerebrovascular disease. This candidate gene region should be tested in population-based samples. ..
  19. Hayashi G, Shen Y, Pedersen T, Newman J, Pook M, Cortopassi G. Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. Hum Mol Genet. 2014;23:6838-47 pubmed publisher
    ..These findings support a neuroinflammatory mechanism in FRDA, which has both pathomechanistic and therapeutic implications. ..
  20. Tam E, Feigenbaum A, Addis J, Blaser S, Mackay N, Al Dosary M, et al. A novel mitochondrial DNA mutation in COX1 leads to strokes, seizures, and lactic acidosis. Neuropediatrics. 2008;39:328-34 pubmed publisher
    ..This case highlights that a MELAS-like syndrome can occur with isolated COX deficiency...
  21. Leijon H, Salmenkivi K, Heiskanen I, Hagstrom J, Louhimo J, Heikkila P, et al. HuR in pheochromocytomas and paragangliomas - overexpression in verified malignant tumors. APMIS. 2016;124:757-63 pubmed publisher
    ..Our data suggest that increased expression of HuR protein is associated with metastatic potential of paragangliomas and pheochromocytomas, and COX-2 seems to be a target of HuR. ..
  22. Chen T, Liu Q, Jiang L, Liu C, Ou Q. Mitochondrial COX2 G7598A mutation may have a modifying role in the phenotypic manifestation of aminoglycoside antibiotic-induced deafness associated with 12S rRNA A1555G mutation in a Han Chinese pedigree. Genet Test Mol Biomarkers. 2013;17:122-30 pubmed publisher
    ..Ala 5 Thr) in the mitochondrial haplogoup M7b1 may have a modifying role, enhancing its penetrance and severity, in the AmAn-induced deafness and NSHL associated with 12S rRNA A1555G mutation in the Han Chinese pedigree. ..
  23. Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
    ..We uncover the importance of COX-2 regarding human cardiomyocyte hypertrophy that will provide a therapeutic intervention in cardiovascular diseases. ..
  24. Tyagi V, Mustafa M, Sharma T, Banerjee B, Ahmed R, Tripathi A, et al. Association of organochlorine pesticides with the mRNA expression of tumour necrosis factor-alpha (TNF-?) & cyclooxygenase-2 (COX-2) genes in idiopathic preterm birth. Indian J Med Res. 2016;143:731-738 pubmed publisher
    ..Evaluating the molecular control of inflammation along with gene environment interaction may be used as a model to explore the aetiology of idiopathic PTB cases and may be considered for the prognosis of adverse reproductive outcomes. ..
  25. Pezzotti A, Kraft P, Hankinson S, Hunter D, Buring J, Cox D. The mitochondrial A10398G polymorphism, interaction with alcohol consumption, and breast cancer risk. PLoS ONE. 2009;4:e5356 pubmed publisher
  26. Spector Chotiner A, Shraga Heled N, Sood R, Rimon G, Barki Harrington L. Prostaglandin receptor EP?-mediated differential degradation of cyclooxygenases involves a specific lysine residue. Biochem Biophys Res Commun. 2014;443:738-42 pubmed publisher
    ..Together these data suggest that distinctive ubiquitination of COX-1 and COX-2 may be responsible for their different sensitivity to EP? -mediated degradation. ..
  27. von Wurmb Schwark N, Schwark T, Caliebe A, Drenske C, Nikolaus S, Schreiber S, et al. Low level of the mtDNA(4977) deletion in blood of exceptionally old individuals. Mech Ageing Dev. 2010;131:179-84 pubmed publisher
    ..The finding was independent of smoking habits, gender or variation in APOE and FOXO3A but could be caused by other environmental and/or genetic factors. ..
  28. Jin X, Wang L, Gong Y, Chen B, Wang Y, Chen T, et al. Leber's Hereditary Optic Neuropathy is Associated with Compound Primary Mutations of Mitochondrial ND1 m.3635G?>?A and ND6 m.14502 T?>?C. Ophthalmic Genet. 2015;36:291-8 pubmed publisher
    ..3635G?>?A. The haplogroup analysis indicated that the mtDNA haplogroup might be an important factor affecting the expression of LHON associated with m.3635G?>?A and/or m.14502T?>?C. ..
  29. Bartova M, Ondrias F, Muy Kheng T, Kastner M, Singer C, Pohlodek K. COX-2, p16 and Ki67 expression in DCIS, microinvasive and early invasive breast carcinoma with extensive intraductal component. Bratisl Lek Listy. 2014;115:445-51 pubmed
    ..This fact might be useful in the evaluation of further behaviour of early breast tumors (Tab. 3, Fig. 8, Ref. 29). ..
  30. Rostoff P, Szczeklik W, Piwowarska W, Konduracka E, Sanak M, Nessler J. [Association of common cyclooxygenase-2 (COX-2) gene polymorphisms with clinical and angiographic characteristics of patients with coronary artery disease]. Przegl Lek. 2014;71:314-8 pubmed
    ..p=0.021 ..
  31. Sicking I, Rommens K, Battista M, Böhm D, Gebhard S, Lebrecht A, et al. Prognostic influence of cyclooxygenase-2 protein and mRNA expression in node-negative breast cancer patients. BMC Cancer. 2014;14:952 pubmed publisher
    ..410). The present findings support the hypothesis that COX-2 protein but not mRNA expression is associated with an unfavorable outcome in node-negative breast cancer. ..
  32. Andalib S, Talebi M, Sakhinia E, Farhoudi M, Sadeghi Bazargani H, Gjedde A. Mitochondrial DNA T4216C and A4917G variations in multiple sclerosis. J Neurol Sci. 2015;356:55-60 pubmed publisher
    ..2 with 95% CI of 0.4-3.5. The present study revealed no association between MS and T4216C variation in the ND1 mtDNA gene and A4917G variation in the mtDNA ND2 gene in the Iranian population. ..
  33. Lu X, Chen F, Liu X, Yuan D, Zi Y, He X, et al. Detection and Clinical Significance of COX-2 Gene SNPs in Gastric Cancer. Cell Biochem Biophys. 2015;72:657-60 pubmed publisher
    ..Our study provides a potential method for screening of susceptible population of gastric cancer for early-stage intervention in patients. ..
  34. Pérez Criado L, Rosas A. Evolutionary anatomy of the Neandertal ulna and radius in the light of the new El Sidrón sample. J Hum Evol. 2017;106:38-53 pubmed publisher
    ..To this aim, twelve adult and adolescent fragmented forelimb elements (including ulnae and radii) of Homo neanderthalensis recovered from the site of El Sidrón (Asturias, Spain) were examined comparatively using three-..
  35. Tseng L, Yin P, Tsai Y, Chi C, Wu C, Lee L, et al. Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues. Oncol Rep. 2009;21:1169-74 pubmed
    ..06) and the > or =50 y/o group (P=0.005). Our findings suggest that mtDNA 4,977-bp deletion associated with NQO1 deficiency is involved in carcinogenesis and progression of breast cancer...
  36. Byun K, Kim D, Bayarsaikhan E, Oh J, Kim J, Kwak G, et al. Changes of calcium binding proteins, c-Fos and COX in hippocampal formation and cerebellum of Niemann-Pick, type C mouse. J Chem Neuroanat. 2013;52:1-8 pubmed publisher
    ..Taken together, reduction of these proteins may be one of the strong phenotypes related to the neuronal degeneration in NPC-/- mice. ..
  37. Im G, Park M, Song J. Effect of urban particles on human middle ear epithelial cells. Int J Pediatr Otorhinolaryngol. 2014;78:777-81 pubmed publisher
    ..UP decreased cell viability, increased the inflammatory response, and increased mucin gene production in HMEECs. These findings indicate that exposure to UP can contribute to the development of otitis media. ..
  38. Holinstat M, Boutaud O, Apopa P, Vesci J, Bala M, Oates J, et al. Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2? differently for cyclooxygenase-1 and 12-lipoxygenase catalysis. Arterioscler Thromb Vasc Biol. 2011;31:435-42 pubmed publisher
    ..The concerted evidence indicates that the platelet thrombin receptors signal activation of cPLA(2?) coupled to COX-1 by a pathway different from that signaling activation of the cPLA(2?) coupled to 12-lipoxygenase. ..
  39. Bourens M, Boulet A, Leary S, Barrientos A. Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase. Hum Mol Genet. 2014;23:2901-13 pubmed publisher
  40. Vural F, Soyer N, Hekimgil M, Cagirgan S, Donmez A, Tombuloglu M. The association between COX-2 expression and survival in myeloma patients. Eur Rev Med Pharmacol Sci. 2014;18:2132-6 pubmed
    ..We conclude that stem cell transplantation might eliminate the detrimental effects of COX-2 positivity. Larger series of patients are needed to investigate this observation. ..
  41. Ou H, Sun D, Peng Y, Wu Y. Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1?-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells. Innate Immun. 2016;22:452-65 pubmed publisher
    ..Our findings demonstrate a clear pro-inflammatory function for NS-398 in the IL-1?-mediated inflammatory response of granulosa cells, at least in part, owing to its augmenting effect on the IL-1?-induced activation of NF-?B. ..
  42. Kucharczyk R, Salin B, di Rago J. Introducing the human Leigh syndrome mutation T9176G into Saccharomyces cerevisiae mitochondrial DNA leads to severe defects in the incorporation of Atp6p into the ATP synthase and in the mitochondrial morphology. Hum Mol Genet. 2009;18:2889-98 pubmed publisher
    ..Interestingly, the T9176G yeast exhibits important anomalies in mitochondrial morphology, an observation which indicates that the pathogenicity of T9176G may not be limited to a bioenergetic deficiency...
  43. Vijaya Padma V, Anitha S, Santhini E, Pradeepa D, Tresa D, Ganesan P, et al. Mitochondrial and nuclear gene mutations in the type 2 diabetes patients of Coimbatore population. Mol Cell Biochem. 2010;345:223-9 pubmed publisher
    ..Our results suggest that the T8356C and GLUT1 gene mutations may have an important role in developing late-onset T2D in Coimbatore population. Particularly, individuals with GLUT1 gene may develop kidney dysfunction at their later age. ..
  44. Xue H, Yao Y, Wang X, Zhang F, Jiang X, Liu J, et al. Interleukin-21 Is Associated with the Pathogenesis of Lumbar Disc Herniation. Iran J Allergy Asthma Immunol. 2015;14:509-18 pubmed
    ..We concluded that inflammation was responsible for the pain associated with LDH, and that increased IL-21 expression may be associated with the pathogenesis of LDH. ..
  45. Miene C, Weise A, Glei M. Impact of polyphenol metabolites produced by colonic microbiota on expression of COX-2 and GSTT2 in human colon cells (LT97). Nutr Cancer. 2011;63:653-62 pubmed publisher
    ..Working with polyphenol metabolites is an important prerequisite to better understand the in vivo effects of pure polyphenols. ..
  46. Kumar M, Pathak D, Kriplani A, Ammini A, Talwar P, Dada R. Nucleotide variations in mitochondrial DNA and supra-physiological ROS levels in cytogenetically normal cases of premature ovarian insufficiency. Arch Gynecol Obstet. 2010;282:695-705 pubmed publisher
  47. Chuang J, Yang W, Lai C, Lin C, Tsai M, Tang C. CTGF inhibits cell motility and COX-2 expression in oral cancer cells. Int Immunopharmacol. 2011;11:948-54 pubmed publisher
    ..Taken together, our results indicated that CTGF inhibits the migration of oral cancer cells by decreasing COX-2 expression through the ?v?5 integrin receptor, FAK, PI3K, Akt, c-Jun and AP-1 signal transduction pathways...
  48. Cai W, Fu Q, Zhou X, Qu J, Tong Y, Guan M. Mitochondrial variants may influence the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation. J Genet Genomics. 2008;35:649-55 pubmed publisher
    ..The results imply that the G6480A, T12811C and A15395G variants might have a potential modifier role in increasing the penetrance and expressivity of the primary LHON-associated G11778A mutation in this Chinese family...
  49. Gomez R, O Keeffe T, Chang L, Huebinger R, Minei J, Barber R. Association of mitochondrial allele 4216C with increased risk for complicated sepsis and death after traumatic injury. J Trauma. 2009;66:850-7; discussion 857-8 pubmed publisher
    ..52; p = 0.02) as well as death (aOR = 4.56; 95% CI: 1.05-19.79; p = 0.04), relative to carriers of the T-allele. Carriage of the mitochondrial 4216C-allele increases the risk for infectious complications and death after severe trauma...
  50. Rollins B, Martin M, Sequeira P, Moon E, Morgan L, Watson S, et al. Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder. PLoS ONE. 2009;4:e4913 pubmed publisher
    ..Focusing on haplogroup and individual susceptibility factors in psychiatric disorders by considering mtDNA variants may lead to innovative treatments to improve mitochondrial health and brain function...
  51. Kaare M, G tz A, Ulander V, Ariansen S, Kaaja R, Suomalainen A, et al. Do mitochondrial mutations cause recurrent miscarriage?. Mol Hum Reprod. 2009;15:295-300 pubmed publisher
    ..In addition, none of the detected variations were previously known to be pathogenic and therefore they are an unlikely cause of miscarriage...
  52. Simon D, Pankratz N, Kissell D, Pauciulo M, Halter C, Rudolph A, et al. Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease. BMC Med Genet. 2010;11:53 pubmed publisher
    ..However, these data do not exclude a role for mtDNA variants in other populations, and it remains possible that other inherited mitochondrial DNA variants, or somatic mDNA mutations, contribute to the risk of familial PD...
  53. Kenney M, Atilano S, Boyer D, Chwa M, Chak G, Chinichian S, et al. Characterization of retinal and blood mitochondrial DNA from age-related macular degeneration patients. Invest Ophthalmol Vis Sci. 2010;51:4289-97 pubmed publisher
    ..These mtDNA variants could diminish energy production efficiency, alter the mtDNA copy numbers and/or impact transcription in AMD retinas...
  54. Mikami E, Fuku N, Takahashi H, Ohiwa N, Scott R, Pitsiladis Y, et al. Mitochondrial haplogroups associated with elite Japanese athlete status. Br J Sports Med. 2011;45:1179-83 pubmed publisher
    ..79, 95% CI 1.28 to 6.07, p=0.007), with 15.0% compared with 6.0% in CON. The results suggest that mitochondrial haplogroups G1 and F are associated with elite EMA and SPA status in Japanese athletes, respectively...
  55. Domingo Gonzalez R, Huang S, Laouar Y, Wilke C, Moore B. COX-2 expression is upregulated by DNA hypomethylation after hematopoietic stem cell transplantation. J Immunol. 2012;189:4528-36 pubmed publisher
    ..Our findings suggest impaired innate immunity and PGE(2) elevation post-BMT are due to hypomethylation of the COX-2 gene, which is at least partly regulated by TGF-?1...
  56. T rkmen I, Ba s ll N, Uraz S, Yerdel M, Mem o lu R, B lb l Do usoy G. CDX2, COX2 and MUC2 expressions in Barrett's esophagus: can they be useful in determination of the dysplasia?. Turk Patoloji Derg. 2012;28:251-8 pubmed publisher
    ..The CDX2, COX2 and MUC2 expressions were seen in the intestinal epithelium having goblet cells. The use of the markers in the diagnosis is controversial but the difference in the Barrett esophagus-dysplasia sequence seems to be meaningful...
  57. Nagoya H, Futagami S, Shimpuku M, Tatsuguchi A, Wakabayashi T, Yamawaki H, et al. Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues. Am J Physiol Gastrointest Liver Physiol. 2014;306:G183-90 pubmed publisher
    ..We concluded that APE-1 is overexpressed and associated with COX-2 expression and VEGF production in esophageal cancer tissues...
  58. Xiong S, Liu X, Yi G. High-density lipoprotein induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through sphingosine kinase-2. Mol Cell Biochem. 2014;389:197-207 pubmed publisher
    ..These findings implicate a novel mechanism underlying anti-atherothrombotic effects of HDL...
  59. Ray A, Zuhlke K, Levin A, Douglas J, Cooney K, Petros J. Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men. Prostate. 2009;69:956-60 pubmed publisher
    ..Additional research will be needed to determine the clinical relevance of these associations in African populations...
  60. Stasinopoulos I, O Brien D, Bhujwalla Z. Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2. Cancer Biol Ther. 2009;8:31-5 pubmed suggest that the profound effects of COX-2 silencing on inhibiting invasion, tumor growth and metastasis from MDA-MB-231 cells are dependent on the induction of IL-1beta-dependent COX-2 and HIF-1alpha but are independent of hypoxia..
  61. Alsbeih G, Al Harbi N, El Sebaie M, Al Rajhi N, Al Hadyan K, Abu Amero K. Involvement of mitochondrial DNA sequence variations and respiratory activity in late complications following radiotherapy. Clin Cancer Res. 2009;15:7352-60 pubmed publisher
    ..Predictive markers of radiosensitivity should take into account mtDNA genetic variations in addition to variations in nuclear genes...
  62. Tong Y, Sun Y, Zhou X, Zhao F, Mao Y, Wei Q, et al. Very low penetrance of Leber's hereditary optic neuropathy in five Han Chinese families carrying the ND1 G3460A mutation. Mol Genet Metab. 2010;99:417-24 pubmed publisher
    ..However, nuclear modifier genes, epigenetic and environmental factors appear to be modifier factors for the phenotypic manifestation of the G3640A mutation in these Chinese families...
  63. Nishigaki Y, Ueno H, Coku J, Koga Y, Fujii T, Sahashi K, et al. Extensive screening system using suspension array technology to detect mitochondrial DNA point mutations. Mitochondrion. 2010;10:300-8 pubmed publisher
    ..This genetic screening platform is useful to reach a definitive diagnosis for mitochondrial diseases...
  64. Luo Y, Tang S, Gao W, Chen L, Yang X, Huang T, et al. Genotyping mitochondrial DNA single nucleotide polymorphisms by PCR ligase detection reactions. Clin Chem Lab Med. 2010;48:475-83 pubmed publisher
    ..The PCR-LDR mtDNA genotyping technique is simple, highly accurate, has high-throughput, and is cost-effective. Therefore, this method is applicable to mtDNA haplotyping in various applications...
  65. Lakatos A, Derbeneva O, Younes D, Keator D, Bakken T, Lvova M, et al. Association between mitochondrial DNA variations and Alzheimer's disease in the ADNI cohort. Neurobiol Aging. 2010;31:1355-63 pubmed publisher
    ..Our results indicate that the mitochondrial haplogroup UK may confer genetic susceptibility to AD independently of the apolipoprotein E4 (APOE4) allele...
  66. Bi R, Zhang A, Yu D, Chen D, Yao Y. Screening the three LHON primary mutations in the general Chinese population by using an optimized multiplex allele-specific PCR. Clin Chim Acta. 2010;411:1671-4 pubmed publisher
    ..The optimized MAS-PCR assay provides an easier, faster and more cost-effective method for detection of the three LHON primary mutations, making it practical for clinical diagnosis...
  67. Zhao Q, Wang C, Zhu J, Wang L, Dong S, Zhang G, et al. RNAi-mediated knockdown of cyclooxygenase2 inhibits the growth, invasion and migration of SaOS2 human osteosarcoma cells: a case control study. J Exp Clin Cancer Res. 2011;30:26 pubmed publisher
    ..In addition, it also reduced VEGF, EGF and bFGF mRNA and protein expression. The COX-2 signaling pathway may provide a novel therapeutic target for the treatment of human osteosarcoma...
  68. Guo Y, Yang T, Liu Y, Shen H, Lei S, Yu N, et al. Mitochondria-wide association study of common variants in osteoporosis. Ann Hum Genet. 2011;75:569-74 pubmed publisher
    ..Subjects classified as haplogroup X had significantly lower hip BMD values than others (P= 0.040). Our results highlighted the importance of mtDNA variants in osteoporosis...
  69. Yang Q, Liu Y, Huang Y, Huang D, Li Y, Wu J, et al. Expression of COX-2, CD44v6 and CD147 and relationship with invasion and lymph node metastasis in hypopharyngeal squamous cell carcinoma. PLoS ONE. 2013;8:e71048 pubmed publisher
    ..In conclusion, the three biomarkers play important roles in tumor invasion and lymph node metastases and might be valuable indicators of tumor metastasis in hypopharyngeal squamous cell carcinoma...
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    ..Taken together, our study revealed the pivotal function of Cox2 in pancreatic cancer, and Cox2 might be an important therapeutic target for the treatment...
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    A complete mitochondrial (mt) genome sequence was reconstructed from a 38,000 year-old Neandertal individual with 8341 mtDNA sequences identified among 4.8 Gb of DNA generated from approximately 0.3 g of bone...
  72. Makita R, Kokaze A, Ohtsu T, Ishikawa M, Matsunaga N, Karita K, et al. Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of daily alcohol drinking on yearly changes in serum total and LDL cholesterol in Japanese men. Acta Med Okayama. 2009;63:331-8 pubmed publisher
    ..047). These results suggest that ND2-237Met has a beneficial impact on yearly changes in serum LDLC in non-daily drinkers but not in daily drinkers...
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    ..The detection of a genetic variant in PDXK, together with evidence accumulating from clinical studies, emphasize the impact of vitamin B6 status and metabolism on disease risk and therapy in PD. ..
  74. Ning L, Ishijima M, Kaneko H, Kurihara H, Arikawa Hirasawa E, Kubota M, et al. Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis. Int Orthop. 2011;35:831-8 pubmed publisher
    ..In conclusion, although synovial inflammation remained active, the MMP-1, COX-2 and IL-1? expression in synovium decreased depending upon the severity of OA, while the TGF-? expression increased...
  75. Subbaramaiah K, Morris P, Zhou X, Morrow M, Du B, Giri D, et al. Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov. 2012;2:356-65 pubmed publisher
    ..These findings help to explain the link among obesity, low-grade chronic inflammation, and breast cancer with important clinical implications...
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    ..The present study demonstrates that gene-environment interactions may identify genes and environmental factors involved in colorectal carcinogenesis...
  78. Xu K, Wang L, Shu H. COX-2 overexpression increases malignant potential of human glioma cells through Id1. Oncotarget. 2014;5:1241-52 pubmed publisher
    ..Thus, COX-2 enhances the malignancy of GBM cells through induction of Id1...
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    ..and metrical point of view and compared with other specimens of Homo erectus, archaic Homo sapiens and Homo neanderthalensis. The MD and BL diameters and the peculiar dental features are archaic and support the antiquity of the ..
  81. Park J, Sharma L, Li H, Xiang R, Holstein D, Wu J, et al. A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet. 2009;18:1578-89 pubmed publisher
    ..Our results indicate that the mtDNA mutations might play an important role in the early stage of cancer development, possibly through alteration of ROS generation and apoptosis...
  82. Jahan S, Khaliq S, Ijaz B, Ahmad W, Hassan S. Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis. Virol J. 2011;8:155 pubmed publisher
    ..Collectively, these studies not only suggest a genotype-specific interaction between key players of HCV pathogenesis but also may represent combined viral and host gene silencing as a potential therapeutic strategy...
  83. Li M, Tan S, Wang X. Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGEâ‚‚ synthesis and COX-2 expression. Oncol Rep. 2014;32:2845-53 pubmed publisher
    ..We expect that paeonol may replace selective COX-2 inhibitors due to their toxic effects, and may offer a new strategy for the therapy of colorectal cancer. ..
  84. Lorenzi I, Oeljeklaus S, Aich A, Ronsör C, Callegari S, Dudek J, et al. The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. Biochim Biophys Acta. 2018;1865:323-333 pubmed publisher
    ..Our data shows that by unbalancing the amount of TMEM177, newly synthesized COX2 accumulates in a COX20-associated state. We conclude that TMEM177 promotes assembly of COX2 at the level of CuA-site formation. ..
  85. Czarnecka A, Krawczyk T, Zdrozny M, Lubi ski J, Arnold R, Kukwa W, et al. Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland. Breast Cancer Res Treat. 2010;121:511-8 pubmed publisher
    ..This difference is highly statistically significant (P = 0.0008). It is therefore possible that the 10398G SNP constitutes an inherited predisposition factor for the development of breast cancer...
  86. Khatami M, Houshmand M, Sadeghizadeh M, Eftekharzadeh M, Heidari M, Saber S, et al. Accumulation of mitochondrial genome variations in Persian LQTS patients: a possible risk factor?. Cardiovasc Pathol. 2010;19:e21-7 pubmed publisher
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    ..In addition, we detected three novel heteroplasmic variants that were potentially pathogenic. Although functional analysis is needed, rare variants in the mtDNA may convey susceptibility to schizophrenia...
  88. Soto I, Fontanesi F, Valledor M, Horn D, Singh R, Barrientos A. Synthesis of cytochrome c oxidase subunit 1 is translationally downregulated in the absence of functional F1F0-ATP synthase. Biochim Biophys Acta. 2009;1793:1776-86 pubmed publisher
    ..Our findings imply that fully assembled ATPase and its proton pumping function are both required for COX biogenesis in yeast and mammalian cells through a mechanism independent of Cox1p synthesis...
  89. D Aurelio M, Vives Bauza C, Davidson M, Manfredi G. Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cells. Hum Mol Genet. 2010;19:374-86 pubmed publisher
    ..Taken together, these results indicate that the mtDNA background plays an important role in modulating the biochemical defects and clinical outcome in NARP/MILS...
  90. Chang B, Cao L, Zhou H. [Expression of COX-2 and VEGF and their correlation with angiogenesis in human clear cell renal cell carcinoma]. Zhonghua Zhong Liu Za Zhi. 2009;31:687-90 pubmed
    ..COX-2 expression is correlated with tumor angiogenesis in CCRCC. It is likely that VEGF is one of the most important mediators in the COX-2 angiogenic pathway...
  91. Huang P, Zhang Y, Zhao T. [The relationship between copy number and microsatellite instability of mitochondrial DNA in colorectal cancer]. Zhonghua Nei Ke Za Zhi. 2009;48:837-40 pubmed
    ..05). However, there was a significant correlation between copy number and mtMSI (P < 0.001). There is a significant reduction of mtDNA in CRC patients, which may be caused by mtMSI...
  92. Kang B, Choi H, Kwon J, Lee J. The 5178C/A and 16189T/C polymorphisms of mitochondrial DNA in Korean men and their associations with blood iron metabolism. Mol Biol Rep. 2010;37:4051-7 pubmed publisher
    ..05). Therefore, our data suggest that the 5178C/A polymorphism in the mtDNA might be useful as a genetic marker with respect to blood iron metabolism. ..