Research Topics

Genomes and Genes

Species

Lysobacter enzymogenes

Summary

Alias: Lysobacter enzymogenes Christensen and Cook 1978

Top Publications

  1. Kudryakova I, Gabdulkhakov A, Tishchenko S, Lysanskaya V, Suzina N, Tsfasman I, et al. Structural and functional properties of antimicrobial protein L5 of Lys?bacter sp. XL1. Appl Microbiol Biotechnol. 2018;: pubmed publisher
    ..XL1 and ?-lytic protease of Lysobacter enzymogenes at a rather low identity of their amino acid sequences...
  2. Li S, Wu X, Zhang L, Shen Y, Du L. Activation of a Cryptic Gene Cluster in Lysobacter enzymogenes Reveals a Module/Domain Portable Mechanism of Nonribosomal Peptide Synthetases in the Biosynthesis of Pyrrolopyrazines. Org Lett. 2017;19:5010-5013 pubmed publisher
    ..Targeted gene inactivation showed that the two-module LedE and the one-module LedF were selectively used in pyrrolopyrazine biosynthesis, revealing a module/domain portable mechanism. ..
  3. Meers P, Liu C, Chen R, Bartos W, Davis J, Dziedzic N, et al. Vesicular delivery of the antifungal antibiotics of Lysobacter enzymogenes C3. Appl Environ Microbiol. 2018;: pubmed publisher
    i>Lysobacter enzymogenes C3 is a predatory strain of gram-negative gliding bacteria that produces antifungal antibiotics by the polyketide synthetic pathway...
  4. Han Y, Wang Y, Tombosa S, Wright S, Huffman J, Yuen G, et al. Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes. Appl Microbiol Biotechnol. 2015;99:801-11 pubmed publisher
    ..LeDSF3 was isolated from the culture broth of Lysobacter enzymogenes, and its chemical structure was established by NMR and MS...
  5. Wang Y, Zhao Y, Zhang J, Zhao Y, Shen Y, Su Z, et al. Transcriptomic analysis reveals new regulatory roles of Clp signaling in secondary metabolite biosynthesis and surface motility in Lysobacter enzymogenes OH11. Appl Microbiol Biotechnol. 2014;98:9009-20 pubmed publisher
    b>Lysobacter enzymogenes is a bacterial biological control agent emerging as a new source of antibiotic metabolites, such as heat-stable antifungal factor (HSAF) and the antibacterial factor WAP-8294A2...
  6. Chen J, Shen D, Odhiambo B, Xu D, Han S, Chou S, et al. Two direct gene targets contribute to Clp-dependent regulation of type IV pilus-mediated twitching motility in Lysobacter enzymogenes OH11. Appl Microbiol Biotechnol. 2018;102:7509-7519 pubmed publisher
    b>Lysobacter enzymogenes is an agriculturally important Gram-negative bacterium that employs a multitude of antifungal mechanisms to inhibit and infect filamentous fungal pathogens, through secretion of antifungal antibiotic HSAF (heat-..
  7. He F, Li B, Ai G, Kange A, Zhao Y, Zhang X, et al. Transcriptomics Analysis of the Chinese Pear Pathotype of Alternaria alternata Gives Insights into Novel Mechanisms of HSAF Antifungal Activities. Int J Mol Sci. 2018;19: pubmed publisher
    ..Heat-stable activity factor (HSAF) is a polycyclic tetramate macrolactam (PTM) produced by Lysobacter enzymogenes and many other microbes with a broad-spectrum antifungal activity against many filamentous fungi...
  8. Tang B, Zhao Y, Shi X, Xu H, Zhao Y, Dai C, et al. Enhanced heat stable antifungal factor production by Lysobacter enzymogenes OH11 with cheap feedstocks: medium optimization and quantitative determination. Lett Appl Microbiol. 2018;66:439-446 pubmed publisher
    ..Thus, this work was executed to optimize the medium composition to maximize HSAF production by Lysobacter enzymogenes OH11, with soybean flour, glucose and CaCl2 identified as suitable nutrients with ..
  9. Takami H, Toyoda A, Uchiyama I, Itoh T, Takaki Y, Arai W, et al. Complete genome sequence and expression profile of the commercial lytic enzyme producer Lysobacter enzymogenes M497-1. DNA Res. 2017;24:169-177 pubmed publisher
    b>Lysobacter enzymogenes M497-1 is a producer of commercialized achromopeptidase and is expected to harbour genes encoding various other antimicrobial enzymes...

More Information

Publications34

  1. Tindall B. The combinations Lysobacter enzymogenes subsp. enzymogenes Christensen and Cook 1978, L. enzymogenes subsp. cookii Christensen 1978 and Streptococcus casseliflavus (Mundt and Graham 1968) Vaughan et al. 1979 were in accordance with the International . Int J Syst Evol Microbiol. 2014;64:3920-1 pubmed publisher
    The Judicial Commission affirms that, according to information presented to it, the combination Lysobacter enzymogenes subsp. enzymogenes Christensen and Cook 1978, the combination Lysobacter enzymogenes subsp...
  2. Xu L, Wu P, Wright S, Du L, Wei X. Bioactive Polycyclic Tetramate Macrolactams from Lysobacter enzymogenes and Their Absolute Configurations by Theoretical ECD Calculations. J Nat Prod. 2015;78:1841-7 pubmed publisher
    ..antifungal factor, 3), 3-dehydroxy HSAF (4), and alteramide A (5) were isolated from a culture of Lysobacter enzymogenes C3 in nutrient yeast glycerol medium. Their structures were determined by MS and extensive NMR analysis...
  3. Zhou X, Qian G, Chen Y, Du L, Liu F, Yuen G. PilG is Involved in the Regulation of Twitching Motility and Antifungal Antibiotic Biosynthesis in the Biological Control Agent Lysobacter enzymogenes. Phytopathology. 2015;105:1318-24 pubmed publisher
    b>Lysobacter enzymogenes strain C3 is a gliding bacterium which produces the antifungal secondary metabolite heat-stable antifungal factor (HSAF) and type IV pilus (T4P) as important mechanisms in biological control activity against fungal ..
  4. Stressler T, Eisele T, Meyer S, Wangler J, Hug T, Lutz Wahl S, et al. Heterologous expression and pro-peptide supported refolding of the high specific endopeptidase Lys-C. Protein Expr Purif. 2016;118:31-8 pubmed publisher
    ..Furthermore, the influence of the native pre-N-pro peptide of Lys-C from Lysobacter enzymogenes ssp. enzymogenes ATCC 27796 on Lys-C refolding was investigated...
  5. Mathioni S, Patel N, Riddick B, Sweigard J, Czymmek K, Caplan J, et al. Transcriptomics of the rice blast fungus Magnaporthe oryzae in response to the bacterial antagonist Lysobacter enzymogenes reveals candidate fungal defense response genes. PLoS ONE. 2013;8:e76487 pubmed publisher
    ..profile of the rice blast pathogen, Magnaporthe oryzae, when challenged with the bacterial antagonist Lysobacter enzymogenes. Based on microscopic observations of interactions between M. oryzae and wild-type L...
  6. Singh H, Won K, Du J, Yang J, Akter S, Kim K, et al. Lysobacter agri sp. nov., a bacterium isolated from soil. Antonie Van Leeuwenhoek. 2015;108:553-61 pubmed publisher
    ..similarity with Lysobacter niastensis KACC 11588(T) followed by Lysobacter panacisoli KACC 17502(T), Lysobacter enzymogenes LMG 8762(T) and Lysobacter oryzae KCTC 22249(T). The G+C content of THG-SKA3(T) was determined to be 68...
  7. Xu G, Zhao Y, Du L, Qian G, Liu F. Hfq regulates antibacterial antibiotic biosynthesis and extracellular lytic-enzyme production in Lysobacter enzymogenes OH11. Microb Biotechnol. 2015;8:499-509 pubmed publisher
    b>Lysobacter enzymogenes is an important biocontrol agent with the ability to produce a variety of lytic enzymes and novel antibiotics. Little is known about their regulatory mechanisms...
  8. Han Y, Wang Y, Yu Y, Chen H, Shen Y, Du L. Indole-Induced Reversion of Intrinsic Multiantibiotic Resistance in Lysobacter enzymogenes. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..tested the effect of blocking two-component regulatory systems (TCSs) on the antibiotic resistance of Lysobacter enzymogenes, a prolific producer of antibiotics...
  9. Zhang W, Huffman J, Li S, Shen Y, Du L. Unusual acylation of chloramphenicol in Lysobacter enzymogenes, a biocontrol agent with intrinsic resistance to multiple antibiotics. BMC Biotechnol. 2017;17:59 pubmed publisher
    ..Because Lysobacter are ubiquitous inhabitants of soil and water, the finding may have important implications in understanding microbial competitions and bioactive natural product regulation. ..
  10. Su Z, Chen H, Wang P, Tombosa S, Du L, Han Y, et al. 4-Hydroxybenzoic acid is a diffusible factor that connects metabolic shikimate pathway to the biosynthesis of a unique antifungal metabolite in Lysobacter enzymogenes. Mol Microbiol. 2017;104:163-178 pubmed publisher
    Heat-stable antifungal factor (HSAF) produced by Lysobacter enzymogenes is a potential lead compound for developing new antibiotics. Yet, how L. enzymogenes regulates the HSAF biosynthesis remains largely unknown...
  11. Miess H, Van Trappen S, Cleenwerck I, De Vos P, Gross H. Reclassification of Pseudomonas sp. PB-6250T as Lysobacter firmicutimachus sp. nov. Int J Syst Evol Microbiol. 2016;66:4162-4166 pubmed publisher
    ..2?%) to the sequence of Lysobacter enzymogenes DSM 2043T, with Lysobacter antibioticus DSM 2044T being the next most closely related species (98...
  12. Xu H, Chen H, Shen Y, Du L, Chou S, Liu H, et al. Direct Regulation of Extracellular Chitinase Production by the Transcription Factor LeClp in Lysobacter enzymogenes OH11. Phytopathology. 2016;106:971-7 pubmed publisher
    b>Lysobacter enzymogenes is a gram-negative bacterial biological control agent that produces abundant extracellular enzymes capable of degrading the cell walls of fungal pathogens...
  13. Hernández I, Fernandez C. Draft Genome Sequence and Assembly of a Lysobacter enzymogenes Strain with Biological Control Activity against Root Knot Nematodes. Genome Announc. 2017;5: pubmed publisher
    i>Lysobacter enzymogenes strain B25, an isolate from an agricultural field, acts as a biological control agent against root knot nematodes in tomato plants...
  14. Wang R, Xu H, Zhao Y, Zhang J, Yuen G, Qian G, et al. Lsp family proteins regulate antibiotic biosynthesis in Lysobacter enzymogenes OH11. AMB Express. 2017;7:123 pubmed publisher
    ..b>Lysobacter enzymogenes, is a non-pathogenic species known for its capacity as a biocontrol agent of plant pathogens...
  15. Chen W, Zhao Y, Cheng J, Zhou X, Salam N, Fang B, et al. Lysobacter cavernae sp. nov., a novel bacterium isolated from a cave sample. Antonie Van Leeuwenhoek. 2016;109:1047-53 pubmed publisher
    ..6 %), Lysobacter soli DCY21(T) (97.5 %), Lysobacter enzymogenes DSM 2043(T) (97.3 %), Lysobacter antibioticus DSM 2044(T) (97.1 %) and Lysobacter panacisoli CJ29(T) (97...
  16. Odhiambo B, Xu G, Qian G, Liu F. Evidence of an Unidentified Extracellular Heat-Stable Factor Produced by Lysobacter enzymogenes (OH11) that Degrade Fusarium graminearum PH1 Hyphae. Curr Microbiol. 2017;74:437-448 pubmed publisher
    b>Lysobacter enzymogenes OH11 produces heat-stable antifungal factor (HSAF) and lytic enzymes possessing antifungal activity. This study bio-prospected for other potential antifungal factors besides those above...
  17. Wang P, Chen H, Qian G, Liu F. LetR is a TetR family transcription factor from Lysobacter controlling antifungal antibiotic biosynthesis. Appl Microbiol Biotechnol. 2017;101:3273-3282 pubmed publisher
    Heat-stable antifungal factor (HSAF) is a newly identified and broad-spectrum antifungal antibiotic from Lysobacter enzymogenes, a ubiquitous environmental proteobacterium. Yet, the regulatory mechanism for HSAF biosynthesis in L...
  18. Chen Y, Xia J, Su Z, Xu G, Gomelsky M, Qian G, et al. Lysobacter PilR, the Regulator of Type IV Pilus Synthesis, Controls Antifungal Antibiotic Production via a Cyclic di-GMP Pathway. Appl Environ Microbiol. 2017;83: pubmed publisher
    i>Lysobacter enzymogenes is a ubiquitous soil gammaproteobacterium that produces a broad-spectrum antifungal antibiotic, known as heat-stable antifungal factor (HSAF)...
  19. Zhou M, Shen D, Xu G, Liu F, Qian G. ChpA Controls Twitching Motility and Broadly Affects Gene Expression in the Biological Control Agent Lysobacter enzymogenes. Curr Microbiol. 2017;74:566-574 pubmed publisher
    b>Lysobacter enzymogenes (L. enzymogenes) is an agriculturally important Gram-negative bacterium that employs T4P (type IV pili)-driven twitching motility to exhibit its antifungal function...
  20. Ding Y, Li Y, Li Z, Zhang J, Lu C, Wang H, et al. Alteramide B is a microtubule antagonist of inhibiting Candida albicans. Biochim Biophys Acta. 2016;1860:2097-106 pubmed publisher
    Alteramide B (ATB), isolated from Lysobacter enzymogenes C3, was a new polycyclic tetramate macrolactam (PTM)...
  21. Han S, Shen D, Zhao Y, Xu D, Liu J, Chou S, et al. Sigma factor RpoN employs a dual transcriptional regulation for controlling twitching motility and biofilm formation in Lysobacter enzymogenes OH11. Curr Genet. 2018;64:515-527 pubmed publisher
    ..enzymogenes. Overall, this study identified chpA as a new target of RpoN for controlling the T4P-mediated twitching motility and biofilm formation in L. enzymogenes OH11. ..
  22. Su Z, Han S, Fu Z, Qian G, Liu F. Heat-Stable Antifungal Factor (HSAF) Biosynthesis in Lysobacter enzymogenes Is Controlled by the Interplay of Two Transcription Factors and a Diffusible Molecule. Appl Environ Microbiol. 2018;84: pubmed publisher
    i>Lysobacter enzymogenes is a Gram-negative, environmentally ubiquitous bacterium that produces a secondary metabolite, called heat-stable antifungal factor (HSAF), as an antifungal factor against plant and animal fungal pathogens...
  23. Xia J, Chen J, Chen Y, Qian G, Liu F. Type IV pilus biogenesis genes and their roles in biofilm formation in the biological control agent Lysobacter enzymogenes OH11. Appl Microbiol Biotechnol. 2018;102:833-846 pubmed publisher
    ..the identification of 26 T4P structural or functional component (SFC) proteins in the Gram-negative Lysobacter enzymogenes, which is a biocontrol agent potentially exploiting T4P-mediated twitching motility for antifungal ..
  24. Yu L, Su W, Fey P, Liu F, Du L. Yield Improvement of the Anti-MRSA Antibiotics WAP-8294A by CRISPR/dCas9 Combined with Refactoring Self-Protection Genes in Lysobacter enzymogenes OH11. ACS Synth Biol. 2018;7:258-266 pubmed publisher
    ..WAP-8294A2 exhibited potent (MIC 0.2-0.8 ?g/mL) and specific activity against S. aureus among a battery of clinically relevant Gram-positive pathogens (54 isolates). ..
  25. Xu H, Wang R, Zhao Y, Fu Z, Qian G, Liu F. LesR is a novel upstream regulator that controls downstream Clp expression to modulate antibiotic HSAF biosynthesis and cell aggregation in Lysobacter enzymogenes OH11. Microb Cell Fact. 2017;16:202 pubmed publisher
    ..hierarchy between DSF signaling and Clp is also conserved in the Gram-negative biological control agent Lysobacter enzymogenes, where the DSF signaling system controls antifungal antibiotic HSAF biosynthesis via Clp...