Cryptococcus neoformans var. neoformans JEC21

Summary

Alias: Cryptococcus neoformans var. neoformans strain JEC21, Filobasidiella neoformans var. neoformans strain JEC21, Cryptococcus neoformans JEC21, Cryptococcus neoformans var. neoformans serotype D JEC21

Top Publications

  1. Idnurm A, Heitman J. Light controls growth and development via a conserved pathway in the fungal kingdom. PLoS Biol. 2005;3:e95 pubmed
    ..These results demonstrate that a role for blue/UV light in controlling development is an ancient process that predates the divergence of the fungi into the ascomycete and basidiomycete phyla. ..
  2. Price M, Nichols C, Alspaugh J. The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. Infect Immun. 2008;76:5729-37 pubmed publisher
    ..This reduction in virulence of the rdi1Delta mutant occurs in the absence of major growth defects in rich medium and with classical virulence-associated phenotypes. ..
  3. Hu G, Steen B, Lian T, Sham A, Tam N, Tangen K, et al. Transcriptional regulation by protein kinase A in Cryptococcus neoformans. PLoS Pathog. 2007;3:e42 pubmed
  4. Yang J, Li D, Liu X, Pan J, Yan B, Zhu X. Regulation of virulence factors, carbon utilization and virulence by SNF1 in Cryptococcus neoformans JEC21 and divergent actions of SNF1 between cryptococcal strains. Fungal Genet Biol. 2010;47:994-1000 pubmed publisher
    ..Revelation of divergent actions of SNF1 may help to understand the evolution of cryptococcal pathogenesis and provides insights into the strain-associated biosynthesis of virulence factors...
  5. Zhao Q, Wei D, Li Z, Wang Y, Zhu X, Zhu X. GWT1 encoding an inositol acyltransferase homolog is required for laccase repression and stress resistance in the basidiomycete Cryptococcus neoformans. FEMS Yeast Res. 2015;15: pubmed publisher
    ..Our results revealed a GPI-dependent glucose repression mechanism in C. neoformans, and it may be helpful for understanding the virulence of C. neoformans. ..
  6. Wollschlaeger C, Trevijano Contador N, Wang X, Legrand M, Zaragoza O, Heitman J, et al. Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating. Fungal Genet Biol. 2014;73:20-8 pubmed publisher
    ..Our data thus suggest the existence of a complex interdependent regulation of exonuclease encoding genes that impact upon virulence and mating in C. neoformans. ..
  7. Dahal G, Viola R. Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans. Acta Crystallogr F Struct Biol Commun. 2015;71:1365-71 pubmed publisher
  8. Yang J, Li D, Pan J, Zhu X. Snf1/AMPK protein kinase modulates cell wall integrity in the human pathogenic yeast cryptococcus neoformans. Wei Sheng Wu Xue Bao. 2011;51:740-6 pubmed
    ..C. neoformans SNF1 was essential for cell wall integrity that was likely responsible for normal adhesion of the cells to agar and resistance to heat. ..
  9. Castle S, Owuor E, Thompson S, Garnsey M, Klutts J, Doering T, et al. Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids. Eukaryot Cell. 2008;7:1611-5 pubmed publisher
    ..neoformans glycosphingolipids. ..
  10. Klutts J, Levery S, Doering T. A beta-1,2-xylosyltransferase from Cryptococcus neoformans defines a new family of glycosyltransferases. J Biol Chem. 2007;282:17890-9 pubmed
    ..Many of the homologous proteins are similar in size to Cxt1p, and all are conserved with respect to the essential DXD motif. These proteins represent a new family of glycosyltransferases, found exclusively within the fungal kingdom. ..

Detail Information

Publications33

  1. Idnurm A, Heitman J. Light controls growth and development via a conserved pathway in the fungal kingdom. PLoS Biol. 2005;3:e95 pubmed
    ..These results demonstrate that a role for blue/UV light in controlling development is an ancient process that predates the divergence of the fungi into the ascomycete and basidiomycete phyla. ..
  2. Price M, Nichols C, Alspaugh J. The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. Infect Immun. 2008;76:5729-37 pubmed publisher
    ..This reduction in virulence of the rdi1Delta mutant occurs in the absence of major growth defects in rich medium and with classical virulence-associated phenotypes. ..
  3. Hu G, Steen B, Lian T, Sham A, Tam N, Tangen K, et al. Transcriptional regulation by protein kinase A in Cryptococcus neoformans. PLoS Pathog. 2007;3:e42 pubmed
  4. Yang J, Li D, Liu X, Pan J, Yan B, Zhu X. Regulation of virulence factors, carbon utilization and virulence by SNF1 in Cryptococcus neoformans JEC21 and divergent actions of SNF1 between cryptococcal strains. Fungal Genet Biol. 2010;47:994-1000 pubmed publisher
    ..Revelation of divergent actions of SNF1 may help to understand the evolution of cryptococcal pathogenesis and provides insights into the strain-associated biosynthesis of virulence factors...
  5. Zhao Q, Wei D, Li Z, Wang Y, Zhu X, Zhu X. GWT1 encoding an inositol acyltransferase homolog is required for laccase repression and stress resistance in the basidiomycete Cryptococcus neoformans. FEMS Yeast Res. 2015;15: pubmed publisher
    ..Our results revealed a GPI-dependent glucose repression mechanism in C. neoformans, and it may be helpful for understanding the virulence of C. neoformans. ..
  6. Wollschlaeger C, Trevijano Contador N, Wang X, Legrand M, Zaragoza O, Heitman J, et al. Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating. Fungal Genet Biol. 2014;73:20-8 pubmed publisher
    ..Our data thus suggest the existence of a complex interdependent regulation of exonuclease encoding genes that impact upon virulence and mating in C. neoformans. ..
  7. Dahal G, Viola R. Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans. Acta Crystallogr F Struct Biol Commun. 2015;71:1365-71 pubmed publisher
  8. Yang J, Li D, Pan J, Zhu X. Snf1/AMPK protein kinase modulates cell wall integrity in the human pathogenic yeast cryptococcus neoformans. Wei Sheng Wu Xue Bao. 2011;51:740-6 pubmed
    ..C. neoformans SNF1 was essential for cell wall integrity that was likely responsible for normal adhesion of the cells to agar and resistance to heat. ..
  9. Castle S, Owuor E, Thompson S, Garnsey M, Klutts J, Doering T, et al. Beta1,2-xylosyltransferase Cxt1p is solely responsible for xylose incorporation into Cryptococcus neoformans glycosphingolipids. Eukaryot Cell. 2008;7:1611-5 pubmed publisher
    ..neoformans glycosphingolipids. ..
  10. Klutts J, Levery S, Doering T. A beta-1,2-xylosyltransferase from Cryptococcus neoformans defines a new family of glycosyltransferases. J Biol Chem. 2007;282:17890-9 pubmed
    ..Many of the homologous proteins are similar in size to Cxt1p, and all are conserved with respect to the essential DXD motif. These proteins represent a new family of glycosyltransferases, found exclusively within the fungal kingdom. ..
  11. Wieckowski Y, Schiefelbein J. Nuclear ribosome biogenesis mediated by the DIM1A rRNA dimethylase is required for organized root growth and epidermal patterning in Arabidopsis. Plant Cell. 2012;24:2839-56 pubmed publisher
    ..Together, these findings provide new insights into the importance of rRNA base modifications and translation regulation for plant growth and development. ..
  12. Aboobakar E, Wang X, Heitman J, Kozubowski L. The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. Eukaryot Cell. 2011;10:1714-23 pubmed publisher
    ..Taken together, these findings support potential roles for Cts1 in endocytic trafficking, mRNA processing, and cytokinesis and suggest that Cts1 is a substrate of calcineurin during high-temperature stress responses. ..
  13. Zhu C, Jiang N, Xiao D, Pan J, Zhu X. Chloride channel-dependent copper acquisition of laccase in the basidiomycetous fungus Cryptococcus neoformans. Sci China Life Sci. 2010;53:125-130 pubmed publisher
    ..CLC-A is a critical factor in copper homeostasis which is required for copper acquisition of laccase in C. neoformans. ..
  14. Pearl E, Tyndall J, Poulter R, Wilbanks S. Sequence requirements for splicing by the Cne PRP8 intein. FEBS Lett. 2007;581:3000-4 pubmed publisher
    ..We propose a model whereby W151 acts to prevent premature C-terminal cleavage, favoring complete splicing as opposed to two disjointed cleavage events...
  15. Lee H, Chang Y, Kwon Chung K. TUP1 disruption reveals biological differences between MATa and MATalpha strains of Cryptococcus neoformans. Mol Microbiol. 2005;55:1222-32 pubmed publisher
    ..This work is the first case in which non-mating-related biological differences are observed between two congenic mating partners in yeast...
  16. Mare L, Iatta R, Montagna M, Luberto C, Del Poeta M. APP1 transcription is regulated by inositol-phosphorylceramide synthase 1-diacylglycerol pathway and is controlled by ATF2 transcription factor in Cryptococcus neoformans. J Biol Chem. 2005;280:36055-64 pubmed publisher
    ..These studies provide novel regulatory mechanisms of the sphingolipid pathway involved in the regulation of gene transcription of C. neoformans...
  17. Lee I, Chow E, Morrow C, Djordjevic J, Fraser J. Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans. Genetics. 2011;188:309-23 pubmed publisher
    ..A murine inhalation model of cryptococcosis revealed that the gat1? mutant is slightly more virulent than wild type, indicating that Gat1 plays a complex regulatory role during infection...
  18. Idnurm A, Heitman J. Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi. Microbiology. 2010;156:2393-407 pubmed publisher
    ..crassa and the zygomycete Phycomyces blakesleeanus, indicating that ferrochelatase is an ancient target of photoregulation in the fungal kingdom...
  19. Klutts J, Doering T. Cryptococcal xylosyltransferase 1 (Cxt1p) from Cryptococcus neoformans plays a direct role in the synthesis of capsule polysaccharides. J Biol Chem. 2008;283:14327-34 pubmed publisher
    ..Cxt1p is the first glycosyltransferase with a defined role in C. neoformans capsule biosynthesis, and cxt1Delta is the only strain identified to date with structural alterations of the capsule polysaccharide GalXM...
  20. Siafakas A, Sorrell T, Wright L, Wilson C, Larsen M, Boadle R, et al. Cell wall-linked cryptococcal phospholipase B1 is a source of secreted enzyme and a determinant of cell wall integrity. J Biol Chem. 2007;282:37508-14 pubmed publisher
    ..This is the first demonstration that Plb1 contributes to fungal survival by maintaining cell wall integrity and that the cell wall is a source of secreted enzyme...
  21. Osterholzer J, Surana R, Milam J, Montano G, Chen G, Sonstein J, et al. Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung. Am J Pathol. 2009;174:932-43 pubmed publisher
    ..These findings provide new insights into mechanisms by which microbial factors contribute to the immunopathology associated with invasive fungal disease...
  22. O Meara T, Norton D, Price M, Hay C, Clements M, Nichols C, et al. Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule. PLoS Pathog. 2010;6:e1000776 pubmed publisher
    ..These results establish a novel mechanism for Rim101 activation and the integration of two conserved signaling cascades in response to host environmental conditions...
  23. Nes W, Zhou W, Ganapathy K, Liu J, Vatsyayan R, Chamala S, et al. Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. Arch Biochem Biophys. 2009;481:210-8 pubmed publisher
  24. Zhang S, Hacham M, Panepinto J, Hu G, Shin S, Zhu X, et al. The Hsp70 member, Ssa1, acts as a DNA-binding transcriptional co-activator of laccase in Cryptococcus neoformans. Mol Microbiol. 2006;62:1090-101 pubmed publisher
    ..Furthermore, deletion of Ssa1 results in reduced laccase and attenuated virulence using a mouse model. These results indicate that Hsp70 functions as a stress-related transcriptional co-activator required for fungal virulence...
  25. Rittershaus P, Kechichian T, Allegood J, Merrill A, Hennig M, Luberto C, et al. Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans. J Clin Invest. 2006;116:1651-9 pubmed publisher
    ..neoformans through the cell cycle. This study establishes C. neoformans GlcCer as a key virulence factor of cryptococcal pathogenicity, with important implications for future development of new antifungal strategies...
  26. Nichols C, Perfect Z, Alspaugh J. A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. Mol Microbiol. 2007;63:1118-30 pubmed publisher
    ..neoformans. In conclusion, our studies illustrate how components of conserved signalling cascades can be specialized for different downstream functions, such as pathogenesis...
  27. Kozubowski L, Aboobakar E, Cardenas M, Heitman J. Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans. Eukaryot Cell. 2011;10:1396-402 pubmed publisher
    ..These results support a model in which calcineurin orchestrates thermal stress responses by associating with sites of mRNA processing...
  28. Hast M, Nichols C, Armstrong S, Kelly S, Hellinga H, Alspaugh J, et al. Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens. J Biol Chem. 2011;286:35149-62 pubmed publisher
    ..Our combined structural and functional studies provide a framework for developing FTase inhibitors to treat invasive fungal infections...
  29. Ekena J, Stanton B, Schiebe Owens J, Hull C. Sexual development in Cryptococcus neoformans requires CLP1, a target of the homeodomain transcription factors Sxi1alpha and Sxi2a. Eukaryot Cell. 2008;7:49-57 pubmed publisher
    ..Our findings lead to a model in which CLP1 is a downstream target of the Sxi proteins that functions to promote growth after mating and to establish the filamentous state, a critical step in the production of spores...
  30. Jones P, Turner K, Djordjevic J, Sorrell T, Wright L, George A. Role of conserved active site residues in catalysis by phospholipase B1 from Cryptococcus neoformans. Biochemistry. 2007;46:10024-32 pubmed publisher
    ..These results provide an explanation for differences in substrate specificity between lipases sharing the cPLA2 catalytic domain fold and for the differential effect of inhibitors on PLB1 enzymatic activities...
  31. Liu X, Yang J. Prp8 intein in fungal pathogens: target for potential antifungal drugs. FEBS Lett. 2004;572:46-50 pubmed publisher
    ..These findings revealed Prp8 inteins as attractive targets for potential antifungal drugs to be identified using existing selection and screening methods...
  32. Butler M, Goodwin T, Poulter R. A nuclear-encoded intein in the fungal pathogen Cryptococcus neoformans. Yeast. 2001;18:1365-70 pubmed publisher
    ..The Cne PRP8 intein may be a useful drug target in addressing the cryptococcal infections so prevalent in AIDS patients...
  33. Xu J, Xue C, Xue D, Zhao J, Gai J, Guo N, et al. Overexpression of GmHsp90s, a heat shock protein 90 (Hsp90) gene family cloning from soybean, decrease damage of abiotic stresses in Arabidopsis thaliana. PLoS ONE. 2013;8:e69810 pubmed publisher