Myxococcus xanthus

Summary

Alias: Myxococcus xanthus retron Mx162, Myxococcus xanthus retron Mx65, Myxococcus xanthus Beebe 1941

Top Publications

  1. Charousová I, Steinmetz H, Medo J, Javoreková S, Wink J. Soil myxobacteria as a potential source of polyketide-peptide substances. Folia Microbiol (Praha). 2017;62:305-315 pubmed publisher
    ..the highest sequence similarity to Corallococcus coralloides (K9-5, NCBI accession number KX256198) and Myxococcus xanthus (V3-1, NCBI accession number KX256197)...
  2. Hallberg Z, Wang X, Wright T, Nan B, Ad O, Yeo J, et al. Hybrid promiscuous (Hypr) GGDEF enzymes produce cyclic AMP-GMP (3', 3'-cGAMP). Proc Natl Acad Sci U S A. 2016;113:1790-5 pubmed publisher
    ..Finally, we validated the predictive power of our analysis by showing that cAG is present in surface-grown Myxococcus xanthus. This study reveals that GGDEF enzymes make alternative cyclic dinucleotides to cdiG and expands the role of ..
  3. Linares D, Alvarez Sieiro P, del Rio B, Ladero V, Redruello B, Martin M, et al. Implementation of the agmatine-controlled expression system for inducible gene expression in Lactococcus lactis. Microb Cell Fact. 2015;14:208 pubmed publisher
    ..The usefulness and efficiency of this system was checked via the reporter gene gfp and by producing PEP (Myxococcus xanthus prolyl-endopeptidase), an enzyme of biomedical interest able to degrade the immunotoxic peptides produced ..
  4. Fang C, Li Y, Li C, Li B, Ren Y, Zheng H, et al. Identification and comparative analysis of microRNAs in barnyardgrass (Echinochloa crus-galli) in response to rice allelopathy. Plant Cell Environ. 2015;38:1368-81 pubmed publisher
    ..More interestingly, inoculation with Myxococcus xanthus significantly increased miRNA expression in the treated BYG. Jointed treatments of ferulic acid and M...
  5. Chang Y, Kjær A, Ortega D, Kovacikova G, Sutherland J, Rettberg L, et al. Architecture of the Vibrio cholerae toxin-coregulated pilus machine revealed by electron cryotomography. Nat Microbiol. 2017;2:16269 pubmed publisher
    ..about half of the components of the TCPM show sequence homology to components of the previously analysed Myxococcus xanthus T4aP machine (T4aPM), we find that their structures are nevertheless remarkably similar...
  6. Sonntag F, Kroner C, Lubuta P, Peyraud R, Horst A, Buchhaupt M, et al. Engineering Methylobacterium extorquens for de novo synthesis of the sesquiterpenoid α-humulene from methanol. Metab Eng. 2015;32:82-94 pubmed publisher
    ..Introduction of a prokaryotic mevalonate pathway from Myxococcus xanthus in combination with ribosome binding site optimization of α-humulene and FPP synthases increased product ..
  7. Tang G, Tang M, Song L, Zhang Y. Biosynthesis of Tetrahydroisoquinoline Antibiotics. Curr Top Med Chem. 2016;16:1717-26 pubmed
    ..the biosynthetic gene cluster of six THIQ antibiotics has been characterized including saframycin Mx1 from Myxococcus xanthus, safracin-B from Pseudomonas fluorescens, saframycin A, naphthyridinomycin, and quinocarcin from ..
  8. Chang Y, Rettberg L, Treuner Lange A, Iwasa J, Søgaard Andersen L, Jensen G. Architecture of the type IVa pilus machine. Science. 2016;351:aad2001 pubmed publisher
    ..We used cryo-electron tomography of intact Myxococcus xanthus cells to visualize type IVa pili and the protein machine that assembles and retracts them (the type IVa ..
  9. Yan F, Burgard C, Popoff A, Zaburannyi N, Zipf G, Maier J, et al. Synthetic biology approaches and combinatorial biosynthesis towards heterologous lipopeptide production. Chem Sci. 2018;9:7510-7519 pubmed publisher
    ..BGCs, each around 30 kb in size, and established heterologous expression platforms using a derivative of Myxococcus xanthus DK1622 as a host...

More Information

Publications109 found, 100 shown here

  1. Inouye M. The first demonstration of the existence of reverse transcriptases in bacteria. Gene. 2017;597:76-77 pubmed publisher
    ..However, through our research on a peculiar single stranded DNA called msDNA in Myxococcus xanthus, it was predicted that its synthesis requires reverse transcriptases...
  2. Kimura Y, Urata M, Okamoto R. Characterizing activities of eukaryotic-like protein kinases with atypical catalytic loop motifs from Myxococcus xanthus. J Biosci Bioeng. 2015;119:511-4 pubmed publisher
    b>Myxococcus xanthus has eukaryotic-like protein kinases (EPKs) with different atypical catalytic loop motifs. Seven out of 14 recombinant M...
  3. Moine A, Espinosa L, Martineau E, Yaikhomba M, Jazleena P, Byrne D, et al. The nucleoid as a scaffold for the assembly of bacterial signaling complexes. PLoS Genet. 2017;13:e1007103 pubmed publisher
    The FrzCD chemoreceptor from the gliding bacterium Myxococcus xanthus forms cytoplasmic clusters that occupy a large central region of the cell body also occupied by the nucleoid...
  4. Chang Y, Rettberg L, Ortega D, Jensen G. In vivo structures of an intact type VI secretion system revealed by electron cryotomography. EMBO Rep. 2017;18:1090-1099 pubmed publisher
    ..Here, we use electron cryotomography to directly visualize intact T6SS structures inside Myxococcus xanthus cells...
  5. Korp J, Winand L, Sester A, Nett M. Engineering pseudochelin production in Myxococcus xanthus. Appl Environ Microbiol. 2018;: pubmed publisher
    ..The resulting vector was introduced into the myxobacterium Myxococcus xanthus DSM16526, a native producer of myxochelin A and B...
  6. Esquilín Lebrón K, Boynton T, Shimkets L, Thomas M. An orphan MbtH-like protein interacts with multiple nonribosomal peptide synthetases in Myxococcus xanthus DK1622. J Bacteriol. 2018;: pubmed publisher
    ..We targeted the orphan MLP MXAN_3118 from Myxococcus xanthus DK1622 for characterization. The M...
  7. Kaiser D, Warrick H. Transmission of a signal that synchronizes cell movements in swarms of Myxococcus xanthus. Proc Natl Acad Sci U S A. 2014;111:13105-10 pubmed publisher
    We offer evidence for a signal that synchronizes the behavior of hundreds of Myxococcus xanthus cells in a growing swarm. Swarms are driven to expand by the periodic reversing of direction by members...
  8. Ahrendt T, Wolff H, Bode H. Neutral and Phospholipids of the Myxococcus xanthus Lipodome during Fruiting Body Formation and Germination. Appl Environ Microbiol. 2015;81:6538-47 pubmed publisher
    ..The model organism Myxococcus xanthus exhibits a highly complex composition of neutral and phospholipids, including triacylglycerols (TAGs), ..
  9. Depas W, Syed A, Sifuentes M, Lee J, Warshaw D, Saggar V, et al. Biofilm formation protects Escherichia coli against killing by Caenorhabditis elegans and Myxococcus xanthus. Appl Environ Microbiol. 2014;80:7079-87 pubmed publisher
    ..coli against killing by the soil-dwelling nematode Caenorhabditis elegans and the predatory bacterium Myxococcus xanthus. Additionally, matrix-encased bacteria at the air-biofilm interface exhibited ∼40-fold-increased ..
  10. Guzzo M, Agrebi R, Espinosa L, Baronian G, Molle V, Mauriello E, et al. Evolution and Design Governing Signal Precision and Amplification in a Bacterial Chemosensory Pathway. PLoS Genet. 2015;11:e1005460 pubmed publisher
    ..In Myxococcus xanthus, a particular chemosensory system (Frz) coordinates the activity of two separate motility systems (the A- ..
  11. Bischof L, Friedrich C, Harms A, Søgaard Andersen L, van der Does C. The Type IV Pilus Assembly ATPase PilB of Myxococcus xanthus Interacts with the Inner Membrane Platform Protein PilC and the Nucleotide-binding Protein PilM. J Biol Chem. 2016;291:6946-57 pubmed publisher
    ..We propose that PilB interacts with PilC and with PilM, thus establishing the connection between the alignment and the motor complex. ..
  12. Wallace R, Black W, Yang X, Yang Z. A CRISPR with roles in Myxococcus xanthus development and exopolysaccharide production. J Bacteriol. 2014;196:4036-43 pubmed publisher
    The Gram-negative soil bacterium Myxococcus xanthus utilizes its social (S) gliding motility to move on surfaces during its vegetative and developmental cycles...
  13. Nair R, Fiegna F, Velicer G. Indirect evolution of social fitness inequalities and facultative social exploitation. Proc Biol Sci. 2018;285: pubmed publisher
    ..The bacterium Myxococcus xanthus sporulates during cooperative development of multicellular fruiting bodies. Using M...
  14. Korch S, Malhotra V, Contreras H, Clark Curtiss J. The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition. J Microbiol. 2015;53:783-95 pubmed publisher
    ..exposure to unfavorable environmental stimuli, several species (Escherichia coli, Staphylococcus aureus, Myxococcus xanthus) employ toxin proteins such as RelE and MazF to downregulate growth or initiate cell death...
  15. Müller S, Strack S, Ryan S, Kearns D, Kirby J. Predation by Myxococcus xanthus induces Bacillus subtilis to form spore-filled megastructures. Appl Environ Microbiol. 2015;81:203-10 pubmed publisher
    ..Prolonged predator-prey interactions between the soil bacterium Myxococcus xanthus and Bacillus subtilis were found to induce the formation of a new type of B...
  16. Balish M. Mycoplasma pneumoniae, an underutilized model for bacterial cell biology. J Bacteriol. 2014;196:3675-82 pubmed publisher
    ..to these model organisms, which include Escherichia coli, Bacillus subtilis, Caulobacter crescentus, and Myxococcus xanthus. Studies of these processes in the pathogenic bacterium Mycoplasma pneumoniae and its close relatives have ..
  17. Schumacher D, Søgaard Andersen L. Fluorescence Live-cell Imaging of the Complete Vegetative Cell Cycle of the Slow-growing Social Bacterium Myxococcus xanthus. J Vis Exp. 2018;: pubmed publisher
    ..Here, we describe a simple protocol to circumvent these limitations in the case of Myxococcus xanthus (which has a generation time of 4 - 6 h). To this end, M...
  18. Cao S, Wu M, Xu S, Yan X, Mao X. Identification of a putative flavin adenine dinucleotide-binding monooxygenase as a regulator for Myxococcus xanthus development. J Bacteriol. 2015;197:1185-96 pubmed publisher
    ..The Myxococcus xanthus Mcu system, encoded by the mcuABCD gene cluster, represents a prototype of the archaic CU family that ..
  19. Giglio K, Zhu C, Klunder C, Kummer S, Garza A. The enhancer binding protein Nla6 regulates developmental genes that are important for Myxococcus xanthus sporulation. J Bacteriol. 2015;197:1276-87 pubmed publisher
    In the bacterium Myxococcus xanthus, starvation triggers the formation of multicellular fruiting bodies containing thousands of stress-resistant spores...
  20. Oka M, Takegawa K, Kimura Y. Enzymatic characterization of a class II lysyl-tRNA synthetase, LysS, from Myxococcus xanthus. Arch Biochem Biophys. 2015;579:33-9 pubmed publisher
    ..We characterized recombinant class II lysyl-tRNA synthetase (LysS) from Myxococcus xanthus and found that it is monomeric and requires Mn(2+) for the synthesis of Ap4A...
  21. Yue X, Cui X, Zhang Z, HU W, Li Z, Zhang Y, et al. Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones in Myxococcus xanthus. Appl Microbiol Biotechnol. 2018;102:5599-5610 pubmed publisher
    ..In this study, we swapped the original promoter of the epothilone biosynthetic gene cluster in Myxococcus xanthus with two endogenous strong promoters P pilA and P groEL1 , respectively, which, ..
  22. Guzzo M, Murray S, Martineau E, Lhospice S, Baronian G, My L, et al. A gated relaxation oscillator mediated by FrzX controls morphogenetic movements in Myxococcus xanthus. Nat Microbiol. 2018;3:948-959 pubmed publisher
    ..In Myxococcus xanthus, MglA, a G protein, and MglB, its cognate GTPase-activating protein, establish a polarity axis that defines ..
  23. Harvey C, Madukoma C, Mahserejian S, Alber M, Shrout J. Cell division resets polarity and motility for the bacterium Myxococcus xanthus. J Bacteriol. 2014;196:3853-61 pubmed publisher
    ..We found an interconnection of division, motility, and polarity in the bacterium Myxococcus xanthus. For every division event, motile cells stop moving to divide...
  24. Holkenbrink C, Hoiczyk E, Kahnt J, Higgs P. Synthesis and assembly of a novel glycan layer in Myxococcus xanthus spores. J Biol Chem. 2014;289:32364-78 pubmed publisher
    b>Myxococcus xanthus is a Gram-negative deltaproteobacterium that has evolved the ability to differentiate into metabolically quiescent spores that are resistant to heat and desiccation...
  25. Rashkov P, Schmitt B, Keilberg D, Beck K, Søgaard Andersen L, Dahlke S. A model for spatio-temporal dynamics in a regulatory network for cell polarity. Math Biosci. 2014;258:189-200 pubmed publisher
    Cell polarity in Myxococcus xanthus is crucial for the directed motility of individual cells. The polarity system is characterised by a dynamic spatio-temporal localisation of the regulatory proteins MglA and MglB at opposite cell poles...
  26. Eckhert E, Rangamani P, Davis A, Oster G, Berleman J. Dual biochemical oscillators may control cellular reversals in Myxococcus xanthus. Biophys J. 2014;107:2700-11 pubmed publisher
    b>Myxococcus xanthus is a Gram-negative, soil-dwelling bacterium that glides on surfaces, reversing direction approximately once every 6 min. Motility in M...
  27. Mi J, Becher D, Lubuta P, Dany S, Tusch K, Schewe H, et al. De novo production of the monoterpenoid geranic acid by metabolically engineered Pseudomonas putida. Microb Cell Fact. 2014;13:170 pubmed publisher
    ..Co-expression of the six genes of the mevalonate pathway from Myxococcus xanthus to establish flux from acetyl-CoA to the universal terpenoid precursor isopentenylpyrophosphate yielded 36 ..
  28. Robinson M, Son B, Kroos D, Kroos L. Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus. BMC Genomics. 2014;15:1123 pubmed publisher
    b>Myxococcus xanthus is a bacterium that undergoes multicellular development when starved. Cells move to aggregation centers and form fruiting bodies in which cells differentiate into dormant spores...
  29. Nan B, Bandaria J, Guo K, Fan X, Moghtaderi A, Yildiz A, et al. The polarity of myxobacterial gliding is regulated by direct interactions between the gliding motors and the Ras homolog MglA. Proc Natl Acad Sci U S A. 2015;112:E186-93 pubmed publisher
    Gliding motility in Myxococcus xanthus is powered by flagella stator homologs that move in helical trajectories using proton motive force...
  30. Skotnicka D, Petters T, Heering J, Hoppert M, Kaever V, Søgaard Andersen L. Cyclic Di-GMP Regulates Type IV Pilus-Dependent Motility in Myxococcus xanthus. J Bacteriol. 2015;198:77-90 pubmed publisher
    ..b>Myxococcus xanthus undergoes major lifestyle changes in response to nutrient availability, with the formation of spreading ..
  31. Rendueles O, Zee P, Dinkelacker I, Amherd M, Wielgoss S, Velicer G. Rapid and widespread de novo evolution of kin discrimination. Proc Natl Acad Sci U S A. 2015;112:9076-81 pubmed publisher
    ..Here, we first use natural isolates of the highly social bacterium Myxococcus xanthus to show that colony-merger incompatibilities can be strong barriers to social interaction, particularly by ..
  32. Ishida Y, Inouye M. Suppression of the toxicity of Bac7 (1-35), a bovine peptide antibiotic, and its production in E. coli. AMB Express. 2016;6:19 pubmed publisher
    ..system, in which Bac7 (1-35) was fused to the C-terminal end of protein S, a major spore-coat protein from Myxococcus xanthus, using a linker containing a Factor Xa cleavage site...
  33. An J, Hong S, Oh D. Regiospecificity of a novel bacterial lipoxygenase from Myxococcus xanthus for polyunsaturated fatty acids. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:823-833 pubmed publisher
    ..The regiospecificity of LOX from Myxococcus xanthus, a gram-negative bacterium, was investigated...
  34. Sigmund F, Massner C, Erdmann P, Stelzl A, Rolbieski H, Desai M, et al. Bacterial encapsulins as orthogonal compartments for mammalian cell engineering. Nat Commun. 2018;9:1990 pubmed publisher
    ..The shell protein (EncA) from Myxococcus xanthus auto-assembles into nanocompartments inside mammalian cells to which sets of native (EncB,C,D) and ..
  35. Perez J, Munoz Dorado J, Moraleda Muñoz A. The complex global response to copper in the multicellular bacterium Myxococcus xanthus. Metallomics. 2018;: pubmed publisher
    ..Bearing in mind that M. xanthus is not very resistant to copper, it is speculated that the complexity of its copper response might be related to its complex life cycle. ..
  36. Chen T, Xiang X, Xu H, Zhang X, Zhou B, Yang Y, et al. LtpA, a CdnL-type CarD regulator, is important for the enzootic cycle of the Lyme disease pathogen. Emerg Microbes Infect. 2018;7:126 pubmed publisher
    ..RNAP-interacting transcription factors, are essential for the viability of Mycobacterium tuberculosis and Myxococcus xanthus. Previous attempts to inactivate ltpA in B. burgdorferi have not been successful...
  37. Vasse M, Wielgoss S. Bacteriophages of Myxococcus xanthus, a Social Bacterium. Viruses. 2018;10: pubmed publisher
    ..Here, we review knowledge on the phages of the myxobacteria with a major focus on phages infecting Myxococcus xanthus, a bacterial model system widely used to study developmental biology and social evolution...
  38. Rajagopalan R, Wielgoss S, Lippert G, Velicer G, Kroos L. devI is an evolutionarily young negative regulator of Myxococcus xanthus development. J Bacteriol. 2015;197:1249-62 pubmed publisher
    During starvation-induced development of Myxococcus xanthus, thousands of rod-shaped cells form mounds in which they differentiate into spores...
  39. Rendueles O, Amherd M, Velicer G. Positively Frequency-Dependent Interference Competition Maintains Diversity and Pervades a Natural Population of Cooperative Microbes. Curr Biol. 2015;25:1673-81 pubmed publisher
    ..frequency-dependent selection among isolates from a local natural population of the highly social bacterium Myxococcus xanthus. Upon starvation, closely related cells of M...
  40. Kimura Y, Urata M. Characterization of a eukaryotic-like protein kinase, DspB, with an atypical catalytic loop motif from Myxococcus xanthus. Arch Microbiol. 2016;198:219-26 pubmed publisher
    ..b>Myxococcus xanthus DspB is a dual-specificity kinase that contains an atypical sequence, RDVAQKN, in the catalytic loop...
  41. Thutupalli S, Sun M, Bunyak F, Palaniappan K, Shaevitz J. Directional reversals enable Myxococcus xanthus cells to produce collective one-dimensional streams during fruiting-body formation. J R Soc Interface. 2015;12:20150049 pubmed publisher
    ..The surface-dwelling bacterium Myxococcus xanthus forms dynamic collective groups both to feed on prey and to aggregate during times of starvation...
  42. Vassallo C, Pathak D, Cao P, Zuckerman D, Hoiczyk E, Wall D. Cell rejuvenation and social behaviors promoted by LPS exchange in myxobacteria. Proc Natl Acad Sci U S A. 2015;112:E2939-46 pubmed publisher
    ..Here we investigated how a model social bacterium, Myxococcus xanthus, approaches this problem...
  43. Islam S, Mignot T. The mysterious nature of bacterial surface (gliding) motility: A focal adhesion-based mechanism in Myxococcus xanthus. Semin Cell Dev Biol. 2015;46:143-54 pubmed publisher
    ..One exception is the gliding motility mechanism used by the Gram-negative social predatory bacterium Myxococcus xanthus. The available body of research suggests that M...
  44. McLoon A, Wuichet K, Häsler M, Keilberg D, Szadkowski D, Søgaard Andersen L. MglC, a Paralog of Myxococcus xanthus GTPase-Activating Protein MglB, Plays a Divergent Role in Motility Regulation. J Bacteriol. 2016;198:510-20 pubmed publisher
    ..In the case of the rod-shaped cells of Myxococcus xanthus, regulated motility is essential for social behaviors. M...
  45. Troselj V, Treuner Lange A, Søgaard Andersen L, Wall D. Physiological Heterogeneity Triggers Sibling Conflict Mediated by the Type VI Secretion System in an Aggregative Multicellular Bacterium. MBio. 2018;9: pubmed publisher
    ..Here, we investigated the interactions between closely related but physiologically distinct Myxococcus xanthus populations...
  46. Sattler S, Wang X, Lewis K, DeHan P, Park C, Xin Y, et al. Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-β-lactamase Superfamily. J Biol Chem. 2015;290:18914-23 pubmed publisher
    ..The crystal structures of two bacterial PDOs from Pseudomonas putida and Myxococcus xanthus were determined at 1.5- and 2.5-Ã… resolution, respectively...
  47. Maughan W, Shuman S. Characterization of 3'-Phosphate RNA Ligase Paralogs RtcB1, RtcB2, and RtcB3 from Myxococcus xanthus Highlights DNA and RNA 5'-Phosphate Capping Activity of RtcB3. J Bacteriol. 2015;197:3616-24 pubmed publisher
    ..bacterial proteomes, and many bacteria have genes encoding two or more RtcB paralogs; an extreme example is Myxococcus xanthus, which has six RtcBs...
  48. Kimura Y, Tanaka C, Oka M. Identification of Major Enzymes Involved in the Synthesis of Diadenosine Tetraphosphate and/or Adenosine Tetraphosphate in Myxococcus xanthus. Curr Microbiol. 2018;75:811-817 pubmed publisher
    b>Myxococcus xanthus generates diadenosine tetraphosphates (Ap4A) and diadenosine pentaphosphates (Ap5A) under various stress conditions. M...
  49. Fu G, Bandaria J, Le Gall A, Fan X, Yildiz A, Mignot T, et al. MotAB-like machinery drives the movement of MreB filaments during bacterial gliding motility. Proc Natl Acad Sci U S A. 2018;115:2484-2489 pubmed publisher
    ..MreB also plays crucial roles in Myxococcus xanthus gliding motility, but the underlying mechanism remains unknown...
  50. Kato T, Shirakawa Y, Takegawa K, Kimura Y. Functional analysis of conserved motifs in a bacterial tyrosine kinase, BtkB, from Myxococcus xanthus. J Biochem. 2015;158:385-92 pubmed publisher
    b>Myxococcus xanthus has two bacterial protein-tyrosine (BY) kinases, BtkA and BtkB...
  51. Bullock H, Shen H, Boynton T, Shimkets L. Fatty Acid Oxidation Is Required for Myxococcus xanthus Development. J Bacteriol. 2018;200: pubmed publisher
    i>Myxococcus xanthus cells produce lipid bodies containing triacylglycerides during fruiting body development. Fatty acid β-oxidation is the most energy-efficient pathway for lipid body catabolism...
  52. Zhu L, Yue X, Han K, Li Z, Zheng L, Yi X, et al. Allopatric integrations selectively change host transcriptomes, leading to varied expression efficiencies of exotic genes in Myxococcus xanthus. Microb Cell Fact. 2015;14:105 pubmed publisher
    ..the integration and expression efficiencies of single and multiple exotic genes that were inserted into Myxococcus xanthus genome by transposition and attB-site-directed recombination...
  53. Liu X, Liu W, Ye B. Regulation of a Protein Acetyltransferase in Myxococcus xanthus by the Coenzyme NADP. J Bacteriol. 2015;198:623-32 pubmed publisher
    ..Here, we show that NADP(+) negatively regulates an acetyltransferase from Myxococcus xanthus, Mxan_3215 (MxKat), at physiologic concentrations...
  54. Schuergers N, Nürnberg D, Wallner T, Mullineaux C, Wilde A. PilB localization correlates with the direction of twitching motility in the cyanobacterium Synechocystis sp. PCC 6803. Microbiology. 2015;161:960-6 pubmed publisher
    ..and the events that lead to a reversal of direction, are best understood in rod-shaped bacteria such as Myxococcus xanthus. In M...
  55. Cusick J, Hager E, Gill R. Identification of a mutant locus that bypasses the BsgA protease requirement for social development in Myxococcus xanthus. FEMS Microbiol Lett. 2015;362:1-8 pubmed publisher
    The BsgA protease is required for the earliest morphological changes observed in Myxococcus xanthus development...
  56. Boynton T, SHIMKETS L. Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases. Genes Dev. 2015;29:1903-14 pubmed publisher
    b>Myxococcus xanthus development requires CsgA, a member of the short-chain alcohol dehydrogenase (SCAD) family of proteins...
  57. Whitworth D, Slade S, Mironas A. Composition of distinct sub-proteomes in Myxococcus xanthus: metabolic cost and amino acid availability. Amino Acids. 2015;47:2521-31 pubmed publisher
    ..and whether we could identify changing patterns of AACB during the life cycle of the social bacterium Myxococcus xanthus. We quantitatively characterised the cellular, soluble secreted, and outer membrane vesicle (OMV) sub-..
  58. Treuner Lange A, Macia E, Guzzo M, Hot E, Faure L, Jakobczak B, et al. The small G-protein MglA connects to the MreB actin cytoskeleton at bacterial focal adhesions. J Cell Biol. 2015;210:243-56 pubmed publisher
    In Myxococcus xanthus the gliding motility machinery is assembled at the leading cell pole to form focal adhesions, translocated rearward to propel the cell, and disassembled at the lagging pole...
  59. Sarwar Z, Garza A. Two-Component Signal Transduction Systems That Regulate the Temporal and Spatial Expression of Myxococcus xanthus Sporulation Genes. J Bacteriol. 2015;198:377-85 pubmed publisher
    When starved for nutrients, Myxococcus xanthus produces a biofilm that contains a mat of rod-shaped cells, known as peripheral rods, and aerial structures called fruiting bodies, which house thousands of dormant and stress-resistant ..
  60. Lemon D, Yang X, Srivastava P, Luk Y, Garza A. Polymertropism of rod-shaped bacteria: movement along aligned polysaccharide fibers. Sci Rep. 2017;7:7643 pubmed publisher
    ..characteristics of polysaccharide substrates influence the behavior of the biofilm-forming bacterium Myxococcus xanthus. M...
  61. Mercier R, Mignot T. Regulations governing the multicellular lifestyle of Myxococcus xanthus. Curr Opin Microbiol. 2016;34:104-110 pubmed publisher
    ..In living organisms, cooperative cell movements underlie the formation of differentiated tissues. In bacteria, Myxococcus xanthus uses cooperative group movements, to predate on prey and to form multicellular fruiting bodies, where the ..
  62. Rajagopalan R, Kroos L. The dev Operon Regulates the Timing of Sporulation during Myxococcus xanthus Development. J Bacteriol. 2017;199: pubmed publisher
    i>Myxococcus xanthus undergoes multicellular development when starved. Thousands of rod-shaped cells coordinate their movements and aggregate into mounds in which cells differentiate into spores...
  63. Schumacher D, Søgaard Andersen L. Regulation of Cell Polarity in Motility and Cell Division in Myxococcus xanthus. Annu Rev Microbiol. 2017;71:61-78 pubmed publisher
    Rod-shaped Myxococcus xanthus cells are polarized with proteins asymmetrically localizing to specific positions. This spatial organization is important for regulation of motility and cell division and changes over time...
  64. Black W, Wang L, Jing X, Saldaña R, Li F, Scharf B, et al. The type IV pilus assembly ATPase PilB functions as a signaling protein to regulate exopolysaccharide production in Myxococcus xanthus. Sci Rep. 2017;7:7263 pubmed publisher
    b>Myxococcus xanthus possesses a form of surface motility powered by the retraction of the type IV pilus (T4P)...
  65. Dey A, Vassallo C, Conklin A, Pathak D, Troselj V, Wall D. Sibling Rivalry in Myxococcus xanthus Is Mediated by Kin Recognition and a Polyploid Prophage. J Bacteriol. 2016;198:994-1004 pubmed publisher
    ..In addition, outer membrane exchange (OME) regulates behaviors, such as inhibition of wild-type Myxococcus xanthus (DK1622) from swarming...
  66. Bretl D, Kirby J. Molecular Mechanisms of Signaling in Myxococcus xanthus Development. J Mol Biol. 2016;428:3805-30 pubmed publisher
    b>Myxococcus xanthus is an environmental bacterium that displays a complex life cycle that includes motility, predation, multicellular fruiting body development, and sporulation...
  67. Kocadag Kocazorbaz E, Zihnioglu F. Purification, characterization and the use of recombinant prolyl oligopeptidase from Myxococcus xanthus for gluten hydrolysis. Protein Expr Purif. 2017;129:101-107 pubmed publisher
    ..In this study recombinant Myxococcus xanthus prolyl oligopeptidase expressed in E. coli was purified 60...
  68. Sabass B, Koch M, Liu G, Stone H, Shaevitz J. Force generation by groups of migrating bacteria. Proc Natl Acad Sci U S A. 2017;114:7266-7271 pubmed publisher
    ..We study two distinct motility mechanisms of Myxococcus xanthus, namely, twitching and gliding...
  69. Pande S, Velicer G. Chimeric Synergy in Natural Social Groups of a Cooperative Microbe. Curr Biol. 2018;28:262-267.e3 pubmed publisher
    ..Cells of the soil bacterium Myxococcus xanthus respond to starvation by constructing multicellular fruiting bodies within each of which a subpopulation of ..
  70. Peng R, Wang Y, Feng W, Yue X, Chen J, Hu X, et al. CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cluster for the epothilone production in Myxococcus xanthus. Microb Cell Fact. 2018;17:15 pubmed publisher
    ..genes for the production of epothilones, we established the CRISPR/dCas9-mediated activation technique in Myxococcus xanthus and analyzed some key factors involving in the CRISPR/dCas9 activation...
  71. Bock T, Kasten J, Muller R, Blankenfeldt W. Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus. Chembiochem. 2016;17:1257-62 pubmed publisher
    ..Here we present crystal structures of MvaS, the HMGCS from Myxococcus xanthus, in complex with CoA and acetylated active site Cys115, with the second substrate acetoacetyl CoA and with ..
  72. Yu Y, Kleiner M, Velicer G. Spontaneous Reversions of an Evolutionary Trait Loss Reveal Regulators of a Small RNA That Controls Multicellular Development in Myxobacteria. J Bacteriol. 2016;198:3142-3151 pubmed
    ..In developmentally proficient strains of Myxococcus xanthus, starvation relaxes the inhibition by Pxr, thereby allowing development to proceed...
  73. Qian H, Xia B, He Y, Lu Z, Bie X, Zhao H, et al. Expression, purification, and characterization of a novel acidic Lipoxygenase from Myxococcus xanthus. Protein Expr Purif. 2017;138:13-17 pubmed publisher
    The gene encoding a novel acidic lipoxygenase from Myxococcus xanthus DK1622 (accession: WP_011551853.1) was cloned into vector pET-28a and expressed in Escherichia coli BL21(DE3)...
  74. Chen I, Velicer G, Yu Y. Divergence of functional effects among bacterial sRNA paralogs. BMC Evol Biol. 2017;17:199 pubmed publisher
    ..The sRNA Pxr functions as a developmental gatekeeper in the model cooperative bacterium Myxococcus xanthus. Specifically, Pxr prevents the initiation of fruiting body development when nutrients are abundant...
  75. An J, Song Y, Kim K, Ko Y, Yoon D, Oh D. Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes. Nat Commun. 2018;9:128 pubmed publisher
    ..Here, we identify ten types of HXs and TrXs, produced by the prokaryote Myxococcus xanthus, of which six types are new, namely, HXB5, HXD3, HXE3, TrXB5, ..
  76. Bock T, Reichelt J, Muller R, Blankenfeldt W. The Structure of LiuC, a 3-Hydroxy-3-Methylglutaconyl CoA Dehydratase Involved in Isovaleryl-CoA Biosynthesis in Myxococcus xanthus, Reveals Insights into Specificity and Catalysis. Chembiochem. 2016;17:1658-64 pubmed publisher
  77. Oka M, Takegawa K, Kimura Y. Lysyl-tRNA synthetase from Myxococcus xanthus catalyzes the formation of diadenosine penta- and hexaphosphates from adenosine tetraphosphate. Arch Biochem Biophys. 2016;604:152-8 pubmed publisher
    b>Myxococcus xanthus lysyl-tRNA synthetase (LysS) produces diadenosine tetraphosphate (Ap4A) from ATP in the presence of Mn(2+); in the present study, it also generated Ap4 from ATP and triphosphate...
  78. Marcos Torres F, Pérez J, Gómez Santos N, Moraleda Muñoz A, Muñoz Dorado J. In depth analysis of the mechanism of action of metal-dependent sigma factors: characterization of CorE2 from Myxococcus xanthus. Nucleic Acids Res. 2016;44:5571-84 pubmed publisher
    ..We have characterized CorE2 from Myxococcus xanthus, which belongs to group ECF44 and upregulates the expression of two genes when it is activated by cadmium ..
  79. Bretl D, Müller S, Ladd K, Atkinson S, Kirby J. Type IV-pili dependent motility is co-regulated by PilSR and PilS2R2 two-component systems via distinct pathways in Myxococcus xanthus. Mol Microbiol. 2016;102:37-53 pubmed publisher
    b>Myxococcus xanthus is an environmental bacterium with two forms of motility. One type, known as social motility, is dependent on extension and retraction of Type-IV pili (T4P) and production of extracellular polysaccharides (EPS)...
  80. Gonzalez I, Vázquez M, Romero Baena A, Barba Brioso C. Stabilization of fly ash using cementing bacteria. Assessment of cementation and trace element mobilization. J Hazard Mater. 2017;321:316-325 pubmed publisher
    ..from municipal solid waste incineration (MSWI) was treated with microorganisms (Sporosarcina pasteurii and Myxococcus xanthus) to assess their capacity for cementing this waste material...
  81. Müller S, Strack S, Ryan S, Shawgo M, Walling A, Harris S, et al. Identification of Functions Affecting Predator-Prey Interactions between Myxococcus xanthus and Bacillus subtilis. J Bacteriol. 2016;198:3335-3344 pubmed
    ..In this study, we report the identification of a large number of genes required for Myxococcus xanthus to engage Bacillus subtilis in a predator-prey relationship...
  82. Yang Y, Wang Y, Li Z, Gong Y, Zhang P, Hu W, et al. Increasing on-target cleavage efficiency for CRISPR/Cas9-induced large fragment deletion in Myxococcus xanthus. Microb Cell Fact. 2017;16:142 pubmed publisher
    ..system for the deletion of large genome fragments related to the biosynthesis of secondary metabolites in Myxococcus xanthus cells. We revealed that the high expression of a codon-optimized cas9 gene in M...
  83. Ikon N, Ryan R. On the origin of 3-methylglutaconic acid in disorders of mitochondrial energy metabolism. J Inherit Metab Dis. 2016;39:749-756 pubmed publisher
    ..The fungus, Ustilago maydis, the myxobacterium, Myxococcus xanthus and the marine cyanobacterium, Lyngbya majuscule, generate 3MG CoA (or acyl carrier protein derivative) in ..
  84. Kraemer S, Wielgoss S, Fiegna F, Velicer G. The biogeography of kin discrimination across microbial neighbourhoods. Mol Ecol. 2016;25:4875-88 pubmed publisher
    ..of social identity and genetic relatedness in local populations of the model cooperative bacterium Myxococcus xanthus at small spatial scales, across which the potential for dispersal is high...
  85. Kroos L. Highly Signal-Responsive Gene Regulatory Network Governing Myxococcus Development. Trends Genet. 2017;33:3-15 pubmed publisher
    The bacterium Myxococcus xanthus undergoes multicellular development when starved. Thousands of cells build mounds in which some differentiate into spores...
  86. Sucipto H, Pogorevc D, Luxenburger E, Wenzel S, Muller R. Heterologous production of myxobacterial ?-pyrone antibiotics in Myxococcus xanthus. Metab Eng. 2017;44:160-170 pubmed publisher
    ..to facilitate rational structure design and yield improvement approaches in the myxobacterial host strain Myxococcus xanthus DK1622...
  87. Sharma G, Khatri I, Subramanian S. Comparative Genomics of Myxobacterial Chemosensory Systems. J Bacteriol. 2018;200: pubmed publisher
    ..Eight CSS, the highest number in bacteria, have been reported in Myxococcus xanthus DK1622 and are involved in coordinating diverse functions...
  88. Lin L, Osorio Valeriano M, Harms A, Søgaard Andersen L, Thanbichler M. Bactofilin-mediated organization of the ParABS chromosome segregation system in Myxococcus xanthus. Nat Commun. 2017;8:1817 pubmed publisher
    ..Here, we study the three bactofilins BacNOP in the rod-shaped bacterium Myxococcus xanthus. We show that BacNOP co-assemble into elongated scaffolds that restrain the ParABS chromosome segregation ..
  89. Patra P, Vassallo C, Wall D, Igoshin O. Mechanism of Kin-Discriminatory Demarcation Line Formation between Colonies of Swarming Bacteria. Biophys J. 2017;113:2477-2486 pubmed publisher
    ..First, using data from competition experiments between kin discriminating strains of Myxococcus xanthus and Proteus mirabilis, we found the rates of killing between the strains to be highly asymmetric, i.e...
  90. Sánchez Sutil M, Marcos Torres F, Pérez J, Ruiz González M, García Bravo E, Martínez Cayuela M, et al. Dissection of the sensor domain of the copper-responsive histidine kinase CorS from Myxococcus xanthus. Environ Microbiol Rep. 2016;8:363-70 pubmed publisher
    b>Myxococcus xanthus CorSR is a two-component system responsible for maintaining the response of this bacterium to copper...
  91. Rendueles O, Velicer G. Evolution by flight and fight: diverse mechanisms of adaptation by actively motile microbes. ISME J. 2017;11:555-568 pubmed publisher
    ..We tested whether 55 populations of the bacterium Myxococcus xanthus that underwent selection for increased fitness at the leading edge of swarming colonies adapted by swarming ..
  92. Zee P, Velicer G. Parallel emergence of negative epistasis across experimental lineages. Evolution. 2017;71:1088-1095 pubmed publisher
    ..evolved lineages to study the emergence and trajectories of epistatic interactions in the social bacterium Myxococcus xanthus. A social gene (pilA) necessary for effective group swarming on soft agar had been deleted from the common ..