Brucella

Summary

Alias: Brucella Meyer and Shaw 1920

Top Publications

  1. Karakeçili F, Cikman A, Akin H, Gülhan B, Ozçiçek A. [A case of brucellosis and Crimean-Congo hemorrhagic fever coinfection in an endemic area]. Mikrobiyol Bul. 2016;50:322-7 pubmed
    ..The tests for brucellosis were conducted and positive results for Brucella Rose Bengal test, tube agglutination (1/160 titers) and immune capture test with Coombs (1/320 titers) were ..
  2. Supuran C. Carbonic anhydrase inhibition/activation: trip of a scientist around the world in the search of novel chemotypes and drug targets. Curr Pharm Des. 2010;16:3233-45 pubmed
    ..glabrata, Saccharomyces cerevisiae) and bacteria (Helicobacter pylori, Mycobacterium tuberculosis, Brucella suis, Streptococcus pneumoniae), being demonstrated that anti-infectives based on their inhibitors might be ..
  3. Ural S, Özer B, Gelal F, Dirim Erdoğan D, Sezak N, Balık R, et al. [Transverse myelitis associated with toxocariasis and the importance of locally produced antibodies for diagnosis]. Mikrobiyol Bul. 2016;50:478-83 pubmed
    ..Viral hepatitis markers, anti-HIV, toxoplasma-IgM, CMV-IgM, rubella-IgM, EBV-VCA-IgM, VDRL, Brucella tube agglutination, echinococcus antibody, autoantibody tests and neuromyelitis optica test were negative...
  4. Supuran C. Inhibition of bacterial carbonic anhydrases and zinc proteases: from orphan targets to innovative new antibiotic drugs. Curr Med Chem. 2012;19:831-44 pubmed
    ..Helycobacter pylori Escherichia coli, Mycobacterium tuberculosis, Brucella spp., Streptococcus pneumoniae, Salmonella enterica, Haemophilus influenzae, Listeria spp, Vibrio spp...
  5. Trawinski H, Gräber S, Leifels M, Schubert S, Lübbert C. [Undulant fever and autoimmune hemolytic anemia in a 20-year-old exchange student from Jordan - the human brucellosis as an important differential diagnosis in migrants]. Dtsch Med Wochenschr. 2015;140:1848-52 pubmed publisher
    ..of yogurt from unpasteurized sheep's milk, we perform serological tests with a strongly positive result for Brucella species, and additional work-up of blood culture isolates confirm the definitive diagnosis of brucellosis (Malta ..
  6. Liu J, Ochieng C, Wiersma S, Ströher U, Towner J, Whitmer S, et al. Development of a TaqMan Array Card for Acute-Febrile-Illness Outbreak Investigation and Surveillance of Emerging Pathogens, Including Ebola Virus. J Clin Microbiol. 2016;54:49-58 pubmed publisher
    ..b>Brucella spp., Coxiella burnetii, Leptospira spp., Rickettsia spp...
  7. Liu N, Liu Z, Lu S, Hu P, Li Y, Feng X, et al. Full-length cDNA cloning, molecular characterization and differential expression analysis of peroxiredoxin 6 from Ovis aries. Vet Immunol Immunopathol. 2015;164:208-19 pubmed publisher
    ..transcription level of Prdx6 in buffy coat was up-regulated in the group infected with a virulent field strain of Brucella melitensis, and down-regulated in the group inoculated with a vaccine strain S2 of brucellosis...
  8. Wareth G, Melzer F, Weise C, Neubauer H, Roesler U, Murugaiyan J. Proteomics-based identification of immunodominant proteins of Brucellae using sera from infected hosts points towards enhanced pathogen survival during the infection. Biochem Biophys Res Commun. 2015;456:202-6 pubmed publisher
    b>Brucella (B.) species lack classical virulence factors, but escape effectively the immune response of the host...
  9. Capasso C, Supuran C. Bacterial, fungal and protozoan carbonic anhydrases as drug targets. Expert Opin Ther Targets. 2015;19:1689-704 pubmed publisher
    ..derivatives lead to inhibition of growth of the pathogen for Helicobacter pylori, Mycobacterium tuberculosis, Brucella suis; ii) Fungi encode for α- and β-CAs, and inhibitors of the sulfonamide, thiol or dithiocarbamate type ..

More Information

Publications256 found, 100 shown here

  1. Curina G, Nardini R, Corneli S, D Avino N, Tentellini M, Montagnoli C, et al. Evaluation of immune responses in mice and sheep inoculated with a live attenuated Brucella melitensis REV1 vaccine produced in bioreactor. Vet Immunol Immunopathol. 2018;198:44-53 pubmed publisher
    The Brucella melitensis REV1 vaccine is the most widely employed vaccine for prophylaxis against brucellosis in sheep and goats. The objective of vaccination is disease control in herds or preventing infection in farms...
  2. Bundle D, McGiven J. Brucellosis: Improved Diagnostics and Vaccine Insights from Synthetic Glycans. Acc Chem Res. 2017;: pubmed publisher
    ..Detection of antibodies to the Brucella bacterial cell wall O-polysaccharide (OPS) component of smooth lipopolysaccharide is used in diagnosis of this ..
  3. Ardigò P, D incau M, Pongolini S. Abortion in cattle due to infection with Staphylococcus lugdunensis. J Vet Diagn Invest. 2014;26:818-20 pubmed publisher
    ..Coxiella burnetii, Chlamydophila abortus, Bovine herpesvirus 1 (BHV-1), Bovine viral diarrhea virus (BVDV), Brucella abortus, and Brucella melitensis...
  4. Tavernier P, Sys S, De Clercq K, De Leeuw I, Caij A, De Baere M, et al. Serologic screening for 13 infectious agents in roe deer (Capreolus capreolus) in Flanders. Infect Ecol Epidemiol. 2015;5:29862 pubmed publisher
    ..7%), bovine viral diarrhoea virus 1 (1.3%), and Coxiella burnetii (1.2%). No antibodies were found against Brucella sp., bovine herpesvirus 1, and bluetongue virus...
  5. Castillo D, Rey Serantes D, Melli L, Ciocchini A, Ugalde J, Comerci D, et al. A recombinant O-polysaccharide-protein conjugate approach to develop highly specific monoclonal antibodies to Shiga toxin-producing Escherichia coli O157 and O145 serogroups. PLoS ONE. 2017;12:e0182452 pubmed publisher
    ..or O145 serogroups, respectively, while no cross-reactivity with other epidemiological important STEC strains, Brucella abortus, Salmonella group N or Yersinia enterocolitica O9 was observed...
  6. Solmaz S, Asma S, Ozdoğu H, Yeral M, Turunç T. [An unusual cause of febrile neutropenia: brucellosis]. Mikrobiyol Bul. 2014;48:669-73 pubmed
    ..Although Brucella spp. infections are endemic in Turkey, brucellosis-related febrile neutropenia has only rarely been reported...
  7. Headley S, Voltarelli D, de Oliveira V, Bronkhorst D, Alfieri A, Filho L, et al. Association of Histophilus somni with spontaneous abortions in dairy cattle herds from Brazil. Trop Anim Health Prod. 2015;47:403-13 pubmed publisher
    ..b>Brucella abortus, and Histophilus somni...
  8. Shapiro A, Brown G, Norris J, Bosward K, Marriot D, Balakrishnan N, et al. Vector-borne and zoonotic diseases of dogs in North-west New South Wales and the Northern Territory, Australia. BMC Vet Res. 2017;13:238 pubmed publisher
    ..and haematological analyses were performed on dogs from the two cohorts (96 dogs in total). Brucella suis serology was determined additionally for the N-W NSW cohort...
  9. Czibener C, Del Giudice M, Spera J, Fulgenzi F, Ugalde J. Delta-pgm, a new live-attenuated vaccine against Brucella suis. Vaccine. 2016;34:1524-1530 pubmed publisher
    ..Each species of the Brucella genus has a particular tropism toward different mammals being the most relevant for human health Brucella abortus,..
  10. Herrou J, Willett J, Czyż D, Babnigg G, Kim Y, Crosson S. Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria. J Bacteriol. 2017;199: pubmed publisher
    i>Brucella abortus σE1 is an EcfG family sigma factor that regulates the transcription of dozens of genes in response to diverse stress conditions and is required for maintenance of chronic infection in a mouse model...
  11. Li Z, Shi J, Fu W, Zhang Y, Zhang J, Wang Z, et al. A Brucella melitensis M5-90 wboA deletion strain is attenuated and enhances vaccine efficacy. Mol Immunol. 2015;66:276-83 pubmed publisher
    b>Brucella spp. are Gram-negative intracellular pathogens of both humans and animals that cause great economic burdens in developing countries...
  12. Völker F, Cooper P, Bader O, Uy A, Zimmermann O, Lugert R, et al. Prevalence of pregnancy-relevant infections in a rural setting of Ghana. BMC Pregnancy Childbirth. 2017;17:172 pubmed publisher
    ..all study participants had specific IgG antibodies against human cytomegalovirus, infections with Listeria, Brucella, or Neisseria gonorrhoeae as well as active syphilis were absent...
  13. Rudrik J, Soehnlen M, Perry M, Sullivan M, Reiter Kintz W, Lee P, et al. Safety and Accuracy of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Highly Pathogenic Organisms. J Clin Microbiol. 2017;55:3513-3529 pubmed publisher
    ..tularensis, Burkholderia mallei, Burkholderia pseudomallei, Clostridium botulinum, Brucella melitensis, Brucella abortus, Brucella suis, and Brucella canis were extracted and ..
  14. Pratt A, DiDonato M, Shin D, Cabelli D, Bruns C, Belzer C, et al. Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus. J Bacteriol. 2015;197:3834-47 pubmed publisher
    Bacterial pathogens Neisseria meningitidis and Brucella abortus pose threats to human and animal health worldwide, causing meningococcal disease and brucellosis, respectively. Mortality from acute N...
  15. Im Y, Shim S, Soh S, Kim S, Yoo H. Cytokines production and toll-like receptors expression in human leukemic monocyte cells, THP-1, stimulated with Brucella abortus cellular antigens. Microb Pathog. 2018;122:7-12 pubmed publisher
    A zoonotic pathogen, Brucella spp. is the causative agent of brucellosis, which results in abortion and loss in milk production in domestic animals, and undulant fever, osteoarticular pain and splenomegaly in humans...
  16. Zhang Y, Li T, Zhang J, Li Z, Zhang Y, Wang Z, et al. The Brucella melitensis M5-90 phosphoglucomutase (PGM) mutant is attenuated and confers protection against wild-type challenge in BALB/c mice. World J Microbiol Biotechnol. 2016;32:58 pubmed publisher
    ..Live attenuated Brucella vaccines (strain M5-90 or others) are the most efficient means for prevention and control of animal brucellosis...
  17. Zamri Saad M, Kamarudin M. Control of animal brucellosis: The Malaysian experience. Asian Pac J Trop Med. 2016;9:1136-1140 pubmed publisher
    ..In cattle, it is caused by Brucella abortus while in goats by Brucella melitensis, the main cause of brucellosis in humans...
  18. Cleveland C, Denicola A, Dubey J, Hill D, Berghaus R, Yabsley M. Survey for selected pathogens in wild pigs (Sus scrofa) from Guam, Marianna Islands, USA. Vet Microbiol. 2017;205:22-25 pubmed publisher
    ..Serologic testing found exposure to Brucella spp...
  19. Mora Cartín R, Chacón Díaz C, Gutiérrez Jiménez C, Gurdián Murillo S, Lomonte B, Chaves Olarte E, et al. N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils. Infect Immun. 2016;84:1712-21 pubmed publisher
    b>Brucella abortus is an intracellular pathogen of monocytes, macrophages, dendritic cells, and placental trophoblasts. This bacterium causes a chronic disease in bovines and in humans...
  20. Barbier T, Collard F, Zúñiga Ripa A, Moriyón I, Godard T, Becker J, et al. Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella. Proc Natl Acad Sci U S A. 2014;111:17815-20 pubmed publisher
    Erythritol is an important nutrient for several α-2 Proteobacteria, including N2-fixing plant endosymbionts and Brucella, a worldwide pathogen that finds this four-carbon polyol in genital tissues...
  21. Pilonieta M, Moreland S, English C, Detweiler C. Salmonella enterica infection stimulates macrophages to hemophagocytose. MBio. 2014;5:e02211 pubmed publisher
    ..accumulate in patients with severe acute bacterial infections, such as those caused by Salmonella enterica, Brucella abortus, and Mycobacterium tuberculosis...
  22. Hop H, Arayan L, Reyes A, Huy T, Min W, Lee H, et al. Simultaneous RNA-seq based transcriptional profiling of intracellular Brucella abortus and B. abortus-infected murine macrophages. Microb Pathog. 2017;113:57-67 pubmed publisher
    b>Brucella is a zoonotic pathogen that survives within macrophages; however the replicative mechanisms involved are not fully understood...
  23. Chen S, Kuo I, Fujitani R, Kabutey N. Endovascular Management of Concomitant Thoracic and Abdominal Aortic Ruptures Resulting from Brucellosis Aortitis. Ann Vasc Surg. 2017;38:190.e1-190.e4 pubmed publisher
    Acute aortic symptomatology is an unusual manifestation of Brucella melitensis infection...
  24. Ducrotoy M, Muñoz P, Conde Alvarez R, Blasco J, Moriyon I. A systematic review of current immunological tests for the diagnosis of cattle brucellosis. Prev Vet Med. 2018;151:57-72 pubmed publisher
    ..Cattle, sheep and goats are infected by smooth Brucella abortus and Brucella melitensis, and represent a common source of the human disease...
  25. de Souza T, de Carvalho T, Mol J, Lopes J, Silva M, da Paixão T, et al. Tissue distribution and cell tropism of Brucella canis in naturally infected canine foetuses and neonates. Sci Rep. 2018;8:7203 pubmed publisher
    b>Brucella canis infection is an underdiagnosed zoonotic disease. Knowledge about perinatal brucellosis in dogs is extremely limited, although foetuses and neonates are under risk of infection due to vertical transmission...
  26. Kim H, Willett J, Jain Gupta N, Fiebig A, Crosson S. The Brucella abortus virulence regulator, LovhK, is a sensor kinase in the general stress response signalling pathway. Mol Microbiol. 2014;94:913-25 pubmed publisher
    In the intracellular pathogen Brucella abortus, the general stress response (GSR) signalling system determines survival under acute stress conditions in vitro, and is required for long-term residence in a mammalian host...
  27. Lee J, Simborio H, Reyes A, Kim D, Hop H, Min W, et al. Immunoproteomic identification of immunodominant antigens independent of the time of infection in Brucella abortus 2308-challenged cattle. Vet Res. 2015;46:17 pubmed publisher
    Brucellosis is a vital zoonotic disease caused by Brucella, which infects a wide range of animals and humans. Accurate diagnosis and reliable vaccination can control brucellosis in domestic animals...
  28. Tevdoradze E, Farlow J, Kotorashvili A, Skhirtladze N, Antadze I, Gunia S, et al. Whole genome sequence comparison of ten diagnostic brucellaphages propagated on two Brucella abortus hosts. Virol J. 2015;12:66 pubmed publisher
    ..propensity for fine-scale genetic variability of diverse brucellaphages grown on multiple hosts within a single Brucella species remains unknown...
  29. Zheng W, Wang Y, Zhang Z, Yan F. Immunological characteristics of outer membrane protein omp31 of goat Brucella and its monoclonal antibody. Genet Mol Res. 2015;14:11965-74 pubmed publisher
    We examined the immunological characteristics of outer membrane protein omp31 of goat Brucella and its monoclonal antibody...
  30. Ducrotoy M, Bertu W, Matope G, Cadmus S, Conde Álvarez R, Gusi A, et al. Brucellosis in Sub-Saharan Africa: Current challenges for management, diagnosis and control. Acta Trop. 2017;165:179-193 pubmed publisher
    Brucellosis is a highly contagious zoonosis caused by bacteria of the genus Brucella and affecting domestic and wild mammals...
  31. Ducrotoy M, Ammary K, Ait Lbacha H, Zouagui Z, Mick V, Prevost L, et al. Narrative overview of animal and human brucellosis in Morocco: intensification of livestock production as a driver for emergence?. Infect Dis Poverty. 2015;4:57 pubmed publisher
    Brucellosis is one of the most widespread zoonoses in the world caused by several species of the genus Brucella. The disease, eradicated in many developed countries, is a re-emerging neglected zoonosis endemic in several zones especially ..
  32. Coria L, Ibañez A, Pasquevich K, Cobiello P, Frank F, Giambartolomei G, et al. Brucella abortus Omp19 recombinant protein subcutaneously co-delivered with an antigen enhances antigen-specific T helper 1 memory responses and induces protection against parasite challenge. Vaccine. 2016;34:430-437 pubmed publisher
    ..work, we demonstrated that subcutaneous co-administration of mice with the outer membrane protein U-Omp19 from Brucella spp...
  33. Tadepalli G, Singh A, Balakrishna K, Murali H, Batra H. Immunogenicity and protective efficacy of Brucella abortus recombinant protein cocktail (rOmp19+rP39) against B. abortus 544 and B. melitensis 16M infection in murine model. Mol Immunol. 2016;71:34-41 pubmed publisher
    In this study, the immunogenicity and protective efficacy of recombinant proteins Omp19 (rO) and P39 (rP) from Brucella abortus were evaluated individually and compared with the cocktail protein (rO+rP) against B...
  34. Megged O, Chazan B, Ganem A, Ayoub A, Yanovskay A, Sakran W, et al. Brucellosis Outbreak in Children and Adults in Two Areas in Israel. Am J Trop Med Hyg. 2016;95:31-4 pubmed publisher
    Two parallel outbreaks of Brucella melitensis infection occurred in 2014 in two geographical areas in Israel...
  35. Ahasan M, Rahman M, Rahman A, Berkvens D. Bovine and Caprine Brucellosis in Bangladesh: Bayesian evaluation of four serological tests, true prevalence, and associated risk factors in household animals. Trop Anim Health Prod. 2017;49:1-11 pubmed publisher
    A cross-sectional study was carried out to estimate the true prevalence of Brucella spp. and identify allied risk factors/indicators associated with brucellosis in the Dinajpur and Mymensingh districts of Bangladesh...
  36. Hashemifar I, Yadegar A, Jazi F, Amirmozafari N. Molecular prevalence of putative virulence-associated genes in Brucella melitensis and Brucella abortus isolates from human and livestock specimens in Iran. Microb Pathog. 2017;105:334-339 pubmed publisher
    Molecular prevalence of nine putative virulence factors in two more prevalent Brucella species in Iranian patients and livestock was investigated...
  37. Mohamed Zahidi J, Ahmad N, Tay B, Hashim R, Khoo E, Ahmad N, et al. Genome Sequences of Brucella melitensis, Isolated from Blood Samples of Brucellosis Patients in Malaysia. Genome Announc. 2017;5: pubmed publisher
    Human brucellosis is a neglected zoonotic disease and has widespread geographical distribution. Brucella melitensis has caused outbreaks and sporadic cases in Malaysia. Here, we present the whole-genome sequences of four B...
  38. Kothalawala K, Makita K, Kothalawala H, Jiffry A, Kubota S, Kono H. Association of farmers' socio-economics with bovine brucellosis epidemiology in the dry zone of Sri Lanka. Prev Vet Med. 2017;147:117-123 pubmed publisher
    The aim of the study was to investigate the farmers' socio-economic factors and their association with Brucella prevalence in the dry zone of Sri Lanka...
  39. Dieste Pérez L, Barberán M, Muñoz P, Moriyón I, Blasco J. Clinical and histological features of brucellin skin test responses in Brucella suis biovar 2 infected pigs. Vet Immunol Immunopathol. 2015;163:77-85 pubmed publisher
    Current serological tests for swine brucellosis detect antibodies to the Brucella O-polysaccharide (O/PS)...
  40. Dong H, Liu W, Peng X, Wu Q. The effects of RegM on stress responses in Brucella melitensis. Curr Microbiol. 2015;70:730-4 pubmed publisher
    b>Brucella melitensis is a facultative intracellular pathogen. The regM gene encodes a sensory transduction protein kinase in B. melitensis 16M, and genes orthologous to regM have been found to exist in many bacterial species...
  41. Ali S, Akhter S, Neubauer H, Melzer F, Khan I, Ali Q, et al. Serological, cultural, and molecular evidence of Brucella infection in small ruminants in Pakistan. J Infect Dev Ctries. 2015;9:470-5 pubmed publisher
    ..Seropositive samples were subjected to bacterial isolation and PCR analysis using Brucella genus-specific (bcsp31) and Brucella species-specific (IS711 for Brucella abortus and Brucella melitensis) ..
  42. Willett J, Herrou J, Briegel A, Rotskoff G, Crosson S. Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen. Proc Natl Acad Sci U S A. 2015;112:E3709-18 pubmed publisher
    ..expression of genes required for growth, division, and intracellular survival of the global zoonotic pathogen Brucella abortus...
  43. Durward Diioia M, Harms J, Khan M, Hall C, Smith J, Splitter G. CD8+ T cell exhaustion, suppressed gamma interferon production, and delayed memory response induced by chronic Brucella melitensis infection. Infect Immun. 2015;83:4759-71 pubmed publisher
    b>Brucella melitensis is a well-adapted zoonotic pathogen considered a scourge of mankind since recorded history...
  44. Kuchuloria T, Imnadze P, Mamuchishvili N, Chokheli M, Tsertsvadze T, Endeladze M, et al. Hospital-Based Surveillance for Infectious Etiologies Among Patients with Acute Febrile Illness in Georgia, 2008-2011. Am J Trop Med Hyg. 2016;94:236-42 pubmed publisher
    ..Blood culture and serologic testing were conducted for Leptospira spp., Brucella spp...
  45. Kim A, Fung E, Parikh S, Gabayan V, Nemeth E, Ganz T. Isocitrate treatment of acute anemia of inflammation in a mouse model. Blood Cells Mol Dis. 2016;56:31-6 pubmed publisher
    ..low-grade AI in a rat model, we used a mouse model of acute and severe AI induced by intraperitoneal heat-killed Brucella abortus to determine if isocitrate would be effective in this more stringent application...
  46. Fernández A, Ferrero M, Hielpos M, Fossati C, Baldi P. Proinflammatory Response of Human Trophoblastic Cells to Brucella abortus Infection and upon Interactions with Infected Phagocytes. Biol Reprod. 2016;94:48 pubmed publisher
    Trophoblasts are targets of infection by Brucella spp. but their role in the pathophysiology of pregnancy complications of brucellosis is unknown...
  47. Sieira R, Bialer M, Roset M, Ruiz Ranwez V, Langer T, Arocena G, et al. Combinatorial control of adhesion of Brucella abortus 2308 to host cells by transcriptional rewiring of the trimeric autotransporter btaE gene. Mol Microbiol. 2017;103:553-565 pubmed publisher
    ..circuit of HutC, a regulator of both metabolic and virulence genes of the facultative intracellular pathogen Brucella. Using in silico and biochemical approaches, we identified a novel functional HutC-binding site upstream of btaE, ..
  48. Franco Paredes C, Chastain D, Taylor P, Stocking S, Sellers B. Boar hunting and brucellosis caused by Brucella suis. Travel Med Infect Dis. 2017;16:18-22 pubmed publisher
    ..case of a 31-year male hunter who six weeks after a knife injury to his hand while field dressing a wild boar, developed a febrile illness associated with hematologic abnormalities and splenic abscesses caused by Brucella suis infection.
  49. Lalsiamthara J, Lee J. Brucella lipopolysaccharide reinforced Salmonella delivering Brucella immunogens protects mice against virulent challenge. Vet Microbiol. 2017;205:84-91 pubmed publisher
    Intracellular pathogen Salmonella exhibits natural infection broadly analogous to Brucella, this phenomenon makes Salmonella a pragmatic choice for an anti-Brucella vaccine delivery platform...
  50. Dutta D, Sen A, Gupta D, Kuila P, Chatterjee D, Sanyal S, et al. Childhood Brucellosis in Eastern India. Indian J Pediatr. 2018;85:266-271 pubmed publisher
    ..9%). The positive results by different diagnostic tools, STAT, RBPT, ELISA- IgM, ELISA-IgG and brucella genus specific PCR were 10.6%, 7.2%, 7.2%, 0.85% and 1.3% respectively...
  51. Chinyoka S, Dhliwayo S, Marabini L, Dutlow K, Matope G, Pfukenyi D. Serological survey of Brucella canis in dogs in urban Harare and selected rural communities in Zimbabwe. J S Afr Vet Assoc. 2014;85:e1-e5 pubmed publisher
    A cross-sectional study was conducted in order to detect antibodies for Brucella canis (B. canis) in dogs from urban Harare and five selected rural communities in Zimbabwe. Sera from randomly selected dogs were tested for antibodies to B...
  52. Elzein F, Mursi M. Case report: Brucella induced Guillain-Barré syndrome. Am J Trop Med Hyg. 2014;91:1179-80 pubmed publisher
    ..Out of 1,028 cases of brucellosis, polyneuritis was reported in only 2 out of 58 patients with neurological involvement. ..
  53. Wahab T, Ferrari S, Lindberg M, Bäckman S, Kaden R. Draft Genome Sequences of Brucella suis Biovar 4 Strain NCTC 10385, Brucella ceti Strain NCTC 12891T, Brucella inopinata Strain CAMP 6436T, and Brucella neotomae Strain ATCC 23459T. Genome Announc. 2014;2: pubmed publisher
    With the aim of developing quantitative PCR methods for the detection and differentiation of Brucella species, the genomes of Brucella ceti, Brucella inopinata, Brucella netotomae, and Brucella suis biovar 4 were sequenced and analyzed.
  54. Gordon J, Christie P. The Agrobacterium Ti Plasmids. Microbiol Spectr. 2014;2: pubmed publisher
    ..and Wolbachia spp., respectively), human pathogens (Brucella spp., Bartonella spp., Rickettsia spp.), and nonpathogens (Caulobacter crescentus, Rhodobacter sphaeroides)...
  55. Ceruso M, Carta F, Osman S, Alothman Z, Monti S, Supuran C. Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties. Bioorg Med Chem. 2015;23:4181-7 pubmed publisher
    ..activities have been determined against the pathogenic fungus Cryptococcus neoformans, the bacterial pathogen Brucella suis and the protozoan parasite Leishmania donovani chagasi, responsible for Leishmaniasis...
  56. Ghasemi A, Jeddi Tehrani M, Mautner J, Salari M, Zarnani A. Simultaneous immunization of mice with Omp31 and TF provides protection against Brucella melitensis infection. Vaccine. 2015;33:5532-5538 pubmed publisher
    b>Brucella vaccines consisting of live attenuated Brucella strains are currently used in livestock, but safety concerns preclude their application in humans...
  57. Mailles A, Garin Bastuji B, Lavigne J, Jay M, Sotto A, Maurin M, et al. Human brucellosis in France in the 21st century: Results from national surveillance 2004-2013. Med Mal Infect. 2016;46:411-418 pubmed publisher
    ..A total of 250 cases were notified, making an annual incidence of 0.3 cases per million inhabitants. Brucella melitensis biovar 3 was the most frequently identified bacterium (79% of isolated strains)...
  58. Khan M, Habibi N, Shaheed F, Mustafa A. Draft Genome Sequences of Five Clinical Strains of Brucella melitensis Isolated from Patients Residing in Kuwait. Genome Announc. 2016;4: pubmed publisher
    ..Here, we present draft genome assemblies of five Brucella melitensis strains isolated from brucellosis patients in Kuwait.
  59. Nagaoka K, Yanagihara K, Morinaga Y, Kohno S. Detection of Fusobacterium nucleatum in two cases of empyema and lung abscess using paromomycin-vancomycin supplemented Brucella HK agar. Anaerobe. 2017;43:99-101 pubmed publisher
    Fusobacterium nucleatum was found in patients with empyema or pulmonary abscess, using paromomycin-vancomycin Brucella HK agar. In vitro examination revealed that growth of the strains differed significantly in different media...
  60. Mirkalantari S, Zarnani A, Nazari M, Irajian G, Amirmozafari N. Brucella melitensis VirB12 recombinant protein is a potential marker for serodiagnosis of human brucellosis. Ann Clin Microbiol Antimicrob. 2017;16:8 pubmed publisher
    ..Previous studies had indicated that Brucella VirB12 protein, a cell surface protein and component of type IV secretion system, induces antibody response ..
  61. Li L, Yin D, Xu K, Liu Y, Song D, Wang J, et al. A sandwich immunoassay for brucellosis diagnosis based on immune magnetic beads and quantum dots. J Pharm Biomed Anal. 2017;141:79-86 pubmed publisher
    ..With the presence of Brucella antibody in the tested serum, the QDs-SPA probe links to the IMB probe and an immune-sandwich complex is formed...
  62. Gürsoy M, Tursun Ä, Alpua M, Haykır Solay A, Tokat Çobanlı M, DemirtaÅŸ H, et al. Brucellosis impairs endothelial functions in chronic symptomatic patients without overt cardiac involvement. Turk Kardiyol Dern Ars. 2015;43:242-9 pubmed publisher
    ..Diagnosis was established by the Rose-Bengal test, positive Brucella standart tube agglutination test, and Coombs STA and/or isolation Brucella species from blood...
  63. Saniee P, Shahreza S, Siavoshi F. Negative Effect of Proton-pump Inhibitors (PPIs) on Helicobacter pylori Growth, Morphology, and Urease Test and Recovery after PPI Removal--An In vitro Study. Helicobacter. 2016;21:143-52 pubmed publisher
    ..PAN did not inhibit H. pylori growth and urease. Three 3-day (9 days) consecutive subcultures of H. pylori on brucella blood agar (BBA) supplemented with OMP resulted in reduced bacterial viability (1+), compared with control (4+), ..
  64. Corrente M, Desario C, Parisi A, Grandolfo E, Scaltrito D, Vesco G, et al. Serological diagnosis of bovine brucellosis using B. melitensis strain B115. J Microbiol Methods. 2015;119:106-9 pubmed publisher
    ..Both tests detect antibodies directed against the lipolysaccharide (LPS) of Brucella cell wall...
  65. Mozo R, Galeote A, Alabart J, Fantova E, Folch J. Evaluating the reproductive ability of breeding rams in North-Eastern Spain using clinical examination of the body and external genitalia. BMC Vet Res. 2015;11:289 pubmed publisher
    ..Blood samples were collected for a serological study of Brucella ovis...
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    Brucellosis caused by Brucella ovis is one of the most important infectious diseases of sheep. The aim of this study was to determine the presence of genes both inside and outside the specific B...
  67. Im Y, Jung M, Shin M, Kim S, Yoo H. Expression of cytokine and apoptosis-related genes in bovine peripheral blood mononuclear cells stimulated with Brucella abortus recombinant proteins. Vet Res. 2016;47:30 pubmed publisher
    ..These results suggest that the cellular antigens of B. abortus induce both humoral and cellular immunity via the production of IL-6, IL-12p40, and IFN-γ in bPBMC without exerting any adverse effects on the cells. ..
  68. Coria L, Ibañez A, Tkach M, Sabbione F, Bruno L, Carabajal M, et al. A Brucella spp. Protease Inhibitor Limits Antigen Lysosomal Proteolysis, Increases Cross-Presentation, and Enhances CD8+ T Cell Responses. J Immunol. 2016;196:4014-29 pubmed publisher
    In this study, we demonstrate that the unlipidated (U) outer membrane protein (Omp) 19 from Brucella spp. is a competitive inhibitor of human cathepsin L...
  69. Wolff C, Boqvist S, Stahl K, Masembe C, Sternberg Lewerin S. Biosecurity aspects of cattle production in Western Uganda, and associations with seroprevalence of brucellosis, salmonellosis and bovine viral diarrhoea. BMC Vet Res. 2017;13:382 pubmed publisher
    ..7% (11.0;23.8), 23.6% (16.9;31.4), and 53.4% (45.0;61.8) for brucella, salmonella and BVD, respectively...
  70. Reyes A, Hop H, Arayan L, Huy T, Park S, Kim K, et al. The host immune enhancing agent Korean red ginseng oil successfully attenuates Brucella abortus infection in a murine model. J Ethnopharmacol. 2017;198:5-14 pubmed publisher
    ..In this study, we elucidated the protective mechanism of the essential oil from Korean red ginseng (RGO) against Brucella infection...
  71. Leong K, Chow T, Wong P, Hamzah S, Ahmad N, Ch ng C. Outbreak of Human Brucellosis from Consumption of Raw Goats' Milk in Penang, Malaysia. Am J Trop Med Hyg. 2015;93:539-41 pubmed publisher
    ..Based on epidemiological clues, Brucella serology was ordered and returned positive...
  72. Chacón Díaz C, Altamirano Silva P, González Espinoza G, Medina M, Alfaro Alarcón A, Bouza Mora L, et al. Brucella canis is an intracellular pathogen that induces a lower proinflammatory response than smooth zoonotic counterparts. Infect Immun. 2015;83:4861-70 pubmed publisher
    Canine brucellosis caused by Brucella canis is a disease of dogs and a zoonotic risk. B...
  73. Garofolo G, Foster J, Drees K, Zilli K, Platone I, Ancora M, et al. Genome Sequences of 11 Brucella abortus Isolates from Persistently Infected Italian Regions. Genome Announc. 2015;3: pubmed publisher
    Bovine brucellosis, typically caused by Brucella abortus, has been eradicated from much of the developed world. However, the disease remains prevalent in southern Italy, persisting as a public and livestock health concern...
  74. Machado G, Santos D, Kohek I, Stein M, Hein H, Poeta A, et al. Seroprevalence of Brucella ovis in rams and associated flock level risk factors in the state of Rio Grande do Sul, Brazil. Prev Vet Med. 2015;121:183-7 pubmed publisher
    ..study based on a planned probabilistic sampling was carried out to estimate animal and flock prevalence of Brucella ovis in rams, as well as to determine risk factors at the flock level...
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    Brucellosis was a common human and livestock disease caused by Brucella strains, the category B priority pathogens by the US Center for Disease Control (CDC)...
  76. Ezama A, Gonzalez J, Majalija S, Bajunirwe F. Assessing short evolution brucellosis in a highly brucella endemic cattle keeping population of Western Uganda: a complementary use of Rose Bengal test and IgM rapid diagnostic test. BMC Public Health. 2018;18:315 pubmed publisher
    ..brucellosis burden among cattle keeping households that are one of the highest risk populations to be exposed to Brucella infection...
  77. Wang X, Wang Y, Ma L, Zhang R, De Y, Yang X, et al. Development of an improved competitive ELISA based on a monoclonal antibody against lipopolysaccharide for the detection of bovine brucellosis. BMC Vet Res. 2015;11:118 pubmed publisher
    ..This study prepared 12 monoclonal antibodies against smooth Brucella lipopolysaccharide...
  78. Deshmukh A, Hagen F, Sharabasi O, Abraham M, Wilson G, Doiphode S, et al. In vitro antimicrobial susceptibility testing of human Brucella melitensis isolates from Qatar between 2014 - 2015. BMC Microbiol. 2015;15:121 pubmed publisher
    ..The aim of this study was to identify the species and determine the antimicrobial susceptibility pattern of Brucella strains isolated from clinical specimens, from Qatar. We evaluated 231 Brucella isolates...
  79. Ahmed W, Zheng K, Liu Z. Establishment of Chronic Infection: Brucella's Stealth Strategy. Front Cell Infect Microbiol. 2016;6:30 pubmed publisher
    b>Brucella is a facultative intracellular pathogen that causes zoonotic infection known as brucellosis which results in abortion and infertility in natural host...
  80. Njuguna J, Gicheru M, Kamau L, Mbatha P. Incidence and knowledge of bovine brucellosis in Kahuro district, Murang'a County, Kenya. Trop Anim Health Prod. 2017;49:1035-1040 pubmed publisher
    Brucellosis in cattle is a zoonosis mainly caused by Brucella abortus. In Kenya, the disease is widespread, but its prevalence is largely unknown...
  81. Hoover Miller A, Dunn J, Field C, Blundell G, Atkinson S. Seroprevalence of Brucella antibodies in harbor seals in Alaska, USA, with age, regional, and reproductive comparisons. Dis Aquat Organ. 2017;126:1-12 pubmed publisher
    ..We measured the seroprevalence of Brucella antibodies in 554 harbor seals in 3 Alaska locations: Prince William Sound (PWS), Glacier Bay (GB), and Tracy Arm ..
  82. Osman A, Saharee A, Jesse F, Kadir A. Comparative experimental study of Brucella melitensis and its lipopolysaccharide in mouse model infected via subcutaneous route of exposure. Microb Pathog. 2018;116:318-327 pubmed publisher
    b>Brucella melitensis is a major zoonotic pathogen in which lipopolysaccharide (LPS) is believed to play a major role in the diseases pathogenesis...
  83. Barkha S, Dharmendra Kumar S, Dhirendra Kumar S. Immunochemical characterization of antigens of Brucella canis and their use in seroprevalence study of canine brucellosis. Asian Pac J Trop Med. 2011;4:857-61 pubmed publisher
    To explore immunochemical characterization of antigens of Brucella canis (B. canis), and the use in seroprevalence study of canine brucellosis...
  84. Yang X, Zhang Q, Guo X. Value of magnetic resonance imaging in brucellar spondylodiscitis. Radiol Med. 2014;119:928-933 pubmed publisher
    ..patients with spondylodiscitis were diagnosed based on positive clinical findings, ≥1/160 titres of brucella agglutination tests and/or positive blood cultures...
  85. Dieste Pérez L, Blasco J, De Miguel M, Moriyón I, Muñoz P. Diagnostic performance of serological tests for swine brucellosis in the presence of false positive serological reactions. J Microbiol Methods. 2015;111:57-63 pubmed publisher
    Swine brucellosis caused by Brucella suis biovar 2 is an emerging disease in Europe...
  86. Golshani M, Rafati S, Dashti A, Gholami E, Siadat S, Oloomi M, et al. Vaccination with recombinant L7/L12-truncated Omp31 protein induces protection against Brucella infection in BALB/c mice. Mol Immunol. 2015;65:287-92 pubmed publisher
    ..In humans, brucellosis is mostly caused by Brucella melitensis and Brucella abortus...
  87. Sepanjnia A, Eskandari Nasab E, Moghadampour M, Tahmasebi A, Dahmardeh F. TGFβ1 genetic variants are associated with an increased risk of acute brucellosis. Infect Dis (Lond). 2015;47:458-64 pubmed publisher
    ..modulates T-cell function, and plays crucial roles in regulation of microbial replication and host responses to brucella. The association of three polymorphisms in the TGFβ1 gene (-509 C/T [rs1800469], + 868 C/T [rs1800470], and + ..
  88. Gouletsou P, Fthenakis G. Microbial diseases of the genital system of rams or bucks. Vet Microbiol. 2015;181:130-5 pubmed publisher
    ..of male small ruminants include orchitis, of bacterial or viral aetiology, epididymitis, primarily caused by Brucella ovis, by other bacteria as well (e.g...
  89. He Z, Gao Y, Dong J, Ke Y, Li X, Chen Z, et al. Crystal structure of cyclic nucleotide-binding-like protein from Brucella abortus. Biochem Biophys Res Commun. 2015;468:647-52 pubmed publisher
    The cyclic nucleotide-binding (CNB)-like protein (CNB-L) from Brucella abortus shares sequence homology with CNB domain-containing proteins. We determined the crystal structure of CNB-L at 2...
  90. Zeng J, Duoji C, Yuan Z, Yuzhen S, Fan W, Tian L, et al. Seroprevalence and risk factors for bovine brucellosis in domestic yaks (Bos grunniens) in Tibet, China. Trop Anim Health Prod. 2017;49:1339-1344 pubmed publisher
    ..The odds of Brucella infection were significantly higher in older Yaks (3-5 years old, OR = 4.51; 95% CI 1.53-19...
  91. Ke Y, Wang Y, Li W, Chen Z. Type IV secretion system of Brucella spp. and its effectors. Front Cell Infect Microbiol. 2015;5:72 pubmed publisher
    b>Brucella spp. are intracellular bacterial pathogens that cause infection in domestic and wild animals. They are often used as model organisms to study intracellular bacterial infections...
  92. Principi N, Esposito S. Infectious Discitis and Spondylodiscitis in Children. Int J Mol Sci. 2016;17:539 pubmed publisher
    ..bacterial pathogens can cause D and SD, and, in some cases, particularly those due to Staphylococcus aureus, Kingella kingae, Mycobacterium tuberculosis, Brucella spp., the appropriate choice of drug is critical to achieve cure.