Experts and Doctors on messenger rna in Chapel Hill, United States

Summary

Locale: Chapel Hill, United States
Topic: messenger rna

Top Publications

  1. Anest V, Hanson J, Cogswell P, Steinbrecher K, Strahl B, Baldwin A. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature. 2003;423:659-63 pubmed
    ..These findings provide additional insight into the role of the IKK complex in NF-kappaB-regulated gene expression. ..
  2. Wang Z, Ingledue T, Dominski Z, Sanchez R, Marzluff W. Two Xenopus proteins that bind the 3' end of histone mRNA: implications for translational control of histone synthesis during oogenesis. Mol Cell Biol. 1999;19:835-45 pubmed
    ..As oocytes mature, SLBP2 is degraded and a larger fraction of the histone mRNA is bound to SLBP1. The mechanism of activation of translation of histone mRNAs may involve exchange of SLBPs associated with the 3' end of histone mRNA. ..
  3. Marzluff W. U2 snRNP: not just for poly(A) mRNAs. Mol Cell. 2007;28:353-4 pubmed
    ..Friend et al. (2007) now report that the U2 snRNP, required for pre-mRNA splicing, is also required for histone mRNA 3' end formation. ..
  4. Maeda N, Li H, Lee D, Oliver P, Quarfordt S, Osada J. Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia. J Biol Chem. 1994;269:23610-6 pubmed
    ..These data indicate that ApoC-III modulates the catabolism of triglyceride-rich lipoproteins and plays a role in the postprandial management of triglycerides. ..
  5. Rhodes N, Connell L, Errede B. STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast. Genes Dev. 1990;4:1862-74 pubmed
    ..The predicted amino acid sequence shows homology to the protein kinase family. We demonstrate that the STE11 product has kinase catalytic activity and that this activity is required for its in vivo functions. ..
  6. Schenkman L, Caruso C, Page N, Pringle J. The role of cell cycle-regulated expression in the localization of spatial landmark proteins in yeast. J Cell Biol. 2002;156:829-41 pubmed
    ..Experiments with chimeric proteins suggest that the critical element(s) is somewhere in the extracytoplasmic domain of Bud8p. ..
  7. Swinnen J, Tsikalas K, Conti M. Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell. J Biol Chem. 1991;266:18370-7 pubmed
    ....
  8. Resseguie M, Song J, Niculescu M, da Costa K, Randall T, Zeisel S. Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J. 2007;21:2622-32 pubmed
    ..This study is the first to explore the underlying mechanism of why dietary requirements for choline vary with estrogen status in humans. ..
  9. Welch J, O Rand M. Characterization of a sperm-specific nuclear autoantigenic protein. II. Expression and localization in the testis. Biol Reprod. 1990;43:569-78 pubmed
    ..NASP was not found in somatic cells. The detection of NASP mRNA transcripts in primary spermatocytes by in situ hybridization supported the immunolocalization results and indicated that NASP expression was under transcriptional control. ..
  10. Popko B, Goodrum J, Bouldin T, Zhang S, Maeda N. Nerve regeneration occurs in the absence of apolipoprotein E in mice. J Neurochem. 1993;60:1155-8 pubmed
    ..These results suggest that the intraneural conservation and reutilization of cholesterol following nerve injury do not require apoE. ..

Locale

Detail Information

Publications62

  1. Anest V, Hanson J, Cogswell P, Steinbrecher K, Strahl B, Baldwin A. A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature. 2003;423:659-63 pubmed
    ..These findings provide additional insight into the role of the IKK complex in NF-kappaB-regulated gene expression. ..
  2. Wang Z, Ingledue T, Dominski Z, Sanchez R, Marzluff W. Two Xenopus proteins that bind the 3' end of histone mRNA: implications for translational control of histone synthesis during oogenesis. Mol Cell Biol. 1999;19:835-45 pubmed
    ..As oocytes mature, SLBP2 is degraded and a larger fraction of the histone mRNA is bound to SLBP1. The mechanism of activation of translation of histone mRNAs may involve exchange of SLBPs associated with the 3' end of histone mRNA. ..
  3. Marzluff W. U2 snRNP: not just for poly(A) mRNAs. Mol Cell. 2007;28:353-4 pubmed
    ..Friend et al. (2007) now report that the U2 snRNP, required for pre-mRNA splicing, is also required for histone mRNA 3' end formation. ..
  4. Maeda N, Li H, Lee D, Oliver P, Quarfordt S, Osada J. Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia. J Biol Chem. 1994;269:23610-6 pubmed
    ..These data indicate that ApoC-III modulates the catabolism of triglyceride-rich lipoproteins and plays a role in the postprandial management of triglycerides. ..
  5. Rhodes N, Connell L, Errede B. STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast. Genes Dev. 1990;4:1862-74 pubmed
    ..The predicted amino acid sequence shows homology to the protein kinase family. We demonstrate that the STE11 product has kinase catalytic activity and that this activity is required for its in vivo functions. ..
  6. Schenkman L, Caruso C, Page N, Pringle J. The role of cell cycle-regulated expression in the localization of spatial landmark proteins in yeast. J Cell Biol. 2002;156:829-41 pubmed
    ..Experiments with chimeric proteins suggest that the critical element(s) is somewhere in the extracytoplasmic domain of Bud8p. ..
  7. Swinnen J, Tsikalas K, Conti M. Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell. J Biol Chem. 1991;266:18370-7 pubmed
    ....
  8. Resseguie M, Song J, Niculescu M, da Costa K, Randall T, Zeisel S. Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J. 2007;21:2622-32 pubmed
    ..This study is the first to explore the underlying mechanism of why dietary requirements for choline vary with estrogen status in humans. ..
  9. Welch J, O Rand M. Characterization of a sperm-specific nuclear autoantigenic protein. II. Expression and localization in the testis. Biol Reprod. 1990;43:569-78 pubmed
    ..NASP was not found in somatic cells. The detection of NASP mRNA transcripts in primary spermatocytes by in situ hybridization supported the immunolocalization results and indicated that NASP expression was under transcriptional control. ..
  10. Popko B, Goodrum J, Bouldin T, Zhang S, Maeda N. Nerve regeneration occurs in the absence of apolipoprotein E in mice. J Neurochem. 1993;60:1155-8 pubmed
    ..These results suggest that the intraneural conservation and reutilization of cholesterol following nerve injury do not require apoE. ..
  11. Yue W, Shackelford J, Pagano J. cdc2/cyclin B1-dependent phosphorylation of EBNA2 at Ser243 regulates its function in mitosis. J Virol. 2006;80:2045-50 pubmed publisher
    ..Our data implicate EBNA2 Ser243 as a cdc2/cyclin B1 site of phosphorylation important for EBNA2's cotranscriptional function in mitosis...
  12. Dudley N, Labbé J, Goldstein B. Using RNA interference to identify genes required for RNA interference. Proc Natl Acad Sci U S A. 2002;99:4191-6 pubmed
    ..The finding that genes predicted to encode proteins that associate with chromatin are involved in RNAi in C. elegans raises the possibility that chromatin may play a role in RNAi in animals, as it does in plants. ..
  13. Robertson A, Howard J, Dominski Z, Schnackenberg B, Sumerel J, McCarthy J, et al. The sea urchin stem-loop-binding protein: a maternally expressed protein that probably functions in expression of multiple classes of histone mRNA. Nucleic Acids Res. 2004;32:811-8 pubmed
    ..SuSLBP expressed by in vitro translation does not bind the stem-loop RNA, suggesting that suSLBP is modified to activate RNA binding in sea urchin embryos. ..
  14. Sitcheran R, Cogswell P, Baldwin A. NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism. Genes Dev. 2003;17:2368-73 pubmed
    ..Thus, in response to cytokine signaling, NF-kappaB modulates the differentiation of mesenchymal-derived cell lineages via RNA sequence-dependent, posttranscriptional down-regulation of key developmental regulators. ..
  15. Dominski Z, Marzluff W. Formation of the 3' end of histone mRNA: getting closer to the end. Gene. 2007;396:373-90 pubmed
    ..The greatest challenge that lies ahead is to determine how all these factors interact with each other to form a catalytically competent processing complex capable of cleaving histone pre-mRNAs. ..
  16. De Virgilio C, Demarini D, Pringle J. SPR28, a sixth member of the septin gene family in Saccharomyces cerevisiae that is expressed specifically in sporulating cells. Microbiology. 1996;142 ( Pt 10):2897-905 pubmed
    ....
  17. Price W. Regulation of insulin-like growth factor (IGF)-binding protein expression by growth factors and cytokines alters IGF-mediated proliferation of postnatal lung fibroblasts. Exp Lung Res. 2004;30:261-83 pubmed
    ..The increase in CM IGFBP-3 following TNF-alpha exposure blocked IGF-mediated cell proliferation, suggesting that the growth factor- and cytokine-mediated changes in IGFBP abundance regulate postnatal fibroblast cell proliferation. ..
  18. Booker J, Reap E, Cohen P. Expression and function of Fas on cells damaged by gamma-irradiation in B6 and B6/lpr mice. J Immunol. 1998;161:4536-41 pubmed
    ..This study demonstrates that lpr mice can produce functional Fas protein. This system is also appropriate for identifying the in vivo role of Fas/FasL in apoptosis following other cell manipulations. ..
  19. Koc E, Spremulli L. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. J Biol Chem. 2002;277:35541-9 pubmed
    ..In addition, the ability of E. coli initiation factor 1 to stimulate initiation complex formation on E. coli 70 S and mitochondrial 55 S ribosomes was investigated in the presence of IF2(mt) and IF3(mt). ..
  20. Godfrey A, White A, Tatomer D, Marzluff W, Duronio R. The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development. RNA. 2009;15:1661-72 pubmed publisher
    ....
  21. Ye P, Li L, Lund P, D Ercole A. Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination. Brain Res Dev Brain Res. 2002;136:111-21 pubmed
    ..Nonetheless, the finding that IGF-I stimulates brain growth less well in the absence of IRS-1 suggests that IRS-1-mediated signaling may be more central to IGF-I action in cells other than glia and oligodendrocytes. ..
  22. Mangiamele L, Burmeister S. Acoustically evoked immediate early gene expression in the pallium of female tĂșngara frogs. Brain Behav Evol. 2008;72:239-50 pubmed publisher
    ....
  23. Zhu X, Mar M, Song J, Zeisel S. Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus. Brain Res Dev Brain Res. 2004;149:121-9 pubmed
    ..This is the first report of altered brain development in Pemt-/- mice. ..
  24. Kaygun H, Marzluff W. Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat Struct Mol Biol. 2005;12:794-800 pubmed
    ..Here we show that regulated degradation of histone mRNAs requires Upf1, a key regulator of the nonsense-mediated decay pathway, and ATR, a key regulator of the DNA damage checkpoint pathway activated during replication stress...
  25. Marzluff W, Sakallah S, Kelkar H. The sea urchin histone gene complement. Dev Biol. 2006;300:308-20 pubmed
    ..The cleavage stage histone H1 is the orthologue of an oocyte-specific histone H1 protein found in vertebrates. ..
  26. Dominski Z, Erkmann J, Greenland J, Marzluff W. Mutations in the RNA binding domain of stem-loop binding protein define separable requirements for RNA binding and for histone pre-mRNA processing. Mol Cell Biol. 2001;21:2008-17 pubmed
    ..It is likely that the RBD of SLBP interacts directly with both the stem-loop RNA and other processing factor(s), most likely the U7 snRNP, to facilitate histone pre-mRNA processing. ..
  27. Kim Y, Hwang I, Tres L, Kierszenbaum A, Chae C. Molecular cloning and differential expression of somatic and testis-specific H2B histone genes during rat spermatogenesis. Dev Biol. 1987;124:23-34 pubmed
    ..H2B and TH2B genes appear to be ideal markers for the study of proliferation and differentiation events in spermatogenesis and their regulatory mechanisms. ..
  28. Dominski Z, Marzluff W. Formation of the 3' end of histone mRNA. Gene. 1999;239:1-14 pubmed
    ..One of the major regulatory events in the cell cycle is regulation of histone pre-mRNA processing, which is at least partially mediated by cell-cycle regulation of the levels of the SLBP protein. ..
  29. Tillotson L. RIN ZF, a novel zinc finger gene, encodes proteins that bind to the CACC element of the gastrin promoter. J Biol Chem. 1999;274:8123-8 pubmed
    ..These findings suggest that a novel set of zinc finger proteins may help regulate gastrin gene expression by interfering with Sp1 transactivation. ..
  30. Gowen L, Johnson B, Latour A, Sulik K, Koller B. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet. 1996;12:191-4 pubmed
    ..In addition, the neuroepithelium in Brca1-deficient embryos appeared disorganized, with signs of both rapid proliferation and excessive cell death. ..
  31. Lin S, Shi Q, Nix F, Styblo M, Beck M, Herbin Davis K, et al. A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol. J Biol Chem. 2002;277:10795-803 pubmed
    ..Because methylation of arsenic is a critical feature of its metabolism, characterization of this enzyme will improve our understanding of this metalloid's metabolism and its actions as a toxin and a carcinogen. ..
  32. Blasband A, Rogers K, Chen X, Azizkhan J, Lee D. Characterization of the rat transforming growth factor alpha gene and identification of promoter sequences. Mol Cell Biol. 1990;10:2111-21 pubmed
    ..In addition, they direct the expression of the bacterial chloramphenicol acetyltransferase gene in transient-transfection assays. ..
  33. Dawson T, Lentsch A, Wang Z, Cowhig J, Rot A, Maeda N, et al. Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC). Blood. 2000;96:1681-4 pubmed
    ..These results suggest that DARC modulates the intensity of inflammatory reactions as a sink for chemokines. (Blood. 2000;96:1681-1684) ..
  34. Yang X, Purdy M, Marzluff W, Dominski Z. Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA. J Biol Chem. 2006;281:30447-54 pubmed
    ..3'hExo removes 3' overhangs of small interfering RNAs, whereas the double-stranded region is resistant to the enzymatic activity. ..
  35. Teotico D, Bischof J, Peng L, Kliewer S, Redinbo M. Structural basis of human pregnane X receptor activation by the hops constituent colupulone. Mol Pharmacol. 2008;74:1512-20 pubmed publisher
    ..Taken together, these results reveal the structural basis for drug-drug interactions mediated by colupulone and related constituents of hops extracts. ..
  36. Rodriguez Enriquez S, Kai Y, Maldonado E, Currin R, Lemasters J. Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes. Autophagy. 2009;5:1099-106 pubmed
    ..These findings indicate that mitochondrial autophagy (mitophagy) and the MPT underlie mitochondrial remodeling in cultured hepatocytes. ..
  37. Ye P, Kollias G, D Ercole A. Insulin-like growth factor-I ameliorates demyelination induced by tumor necrosis factor-alpha in transgenic mice. J Neurosci Res. 2007;85:712-22 pubmed
    ..Our results indicate that IGF-I is capable of protecting myelin and oligodendrocytes from TNF-alpha-induced damage in vivo. ..
  38. Yarbrough W, Quarmby V, Simental J, Joseph D, Sar M, Lubahn D, et al. A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. J Biol Chem. 1990;265:8893-900 pubmed
    ..Thus, arginine 734 appears essential for normal AR function both in androgen binding and transcriptional activation. Absence of these functions results in androgen insensitivity and lack of male sexual development. ..
  39. Chen L, Johnson R, Milgram S. P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. J Biol Chem. 1998;273:33524-32 pubmed
    ..The data suggest that P-CIP1 associates with vesicles in the recycling endosomal pathway, and may play a role in regulating the trafficking of integral membrane PAM. ..
  40. Fleming G, Belhumeur P, Skup D, Fried H. Functional substitution of mouse ribosomal protein L27' for yeast ribosomal protein L29 in yeast ribosomes. Proc Natl Acad Sci U S A. 1989;86:217-21 pubmed
    ..We conclude that mouse ribosomal protein L27' is assembled into ribosomes in yeast, but yeast L29 is assembled preferentially when both L29 and L27' are present in the same cell. ..
  41. Wilkinson K, Gorelick R, Vasa S, Guex N, Rein A, Mathews D, et al. High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states. PLoS Biol. 2008;6:e96 pubmed publisher
    ..High-throughput SHAPE reveals a comprehensive view of HIV-1 RNA genome structure, and further application of this technology will make possible newly informative analysis of any RNA in a cellular transcriptome. ..
  42. Hagaman J, Moyer J, Bachman E, Sibony M, Magyar P, Welch J, et al. Angiotensin-converting enzyme and male fertility. Proc Natl Acad Sci U S A. 1998;95:2552-7 pubmed
    ..Males heterozygous for the mutation inactivating both ACE isozymes sire wild-type and heterozygous offspring at an indistinguishable frequency, indicating no selection against sperm carrying the mutation. ..
  43. Jin D, Zhang T, Gui T, Stafford D, Monahan P. Creation of a mouse expressing defective human factor IX. Blood. 2004;104:1733-9 pubmed
    ..In contrast, given the same treatment, FIXKO mice consistently develop antibodies. Our R333Q-hFIX mice strain will complement the FIXKO mice for studying factor IX circulating kinetics and gene therapy. ..
  44. Martino M, Olsen J, Fulcher N, Wolfgang M, O Neal W, Ribeiro C. Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1. J Biol Chem. 2009;284:14904-13 pubmed publisher
    ..These findings suggest that, in inflamed HBE, XBP-1s is responsible for the ER/Ca(2+) store expansion that confers amplification of Ca(2+)-dependent inflammatory responses. ..
  45. Beach D, Bloom K. ASH1 mRNA localization in three acts. Mol Biol Cell. 2001;12:2567-77 pubmed
    ....
  46. Mochida Y, Parisuthiman D, Pornprasertsuk Damrongsri S, Atsawasuwan P, Sricholpech M, Boskey A, et al. Decorin modulates collagen matrix assembly and mineralization. Matrix Biol. 2009;28:44-52 pubmed publisher
    ..These results suggest that DCN regulates matrix mineralization by modulating collagen assembly. ..
  47. Zimmerman E, Huang M, Leisewitz A, Wang Y, Yang J, Graves L. Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells. FEBS Lett. 2009;583:425-9 pubmed publisher
    ..These results define G24 as critical amino acid for ENT1 nucleoside uptake and suggest that mutations in TM1 may provide a mechanism for Ara-C resistance in CCRF-CEM Ara-C/8C cells...
  48. Watanabe M, Osada J, Aratani Y, Kluckman K, Reddick R, Malinow M, et al. Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A. 1995;92:1585-9 pubmed
    ..Thus, the heterozygous mutants are promising for studying the in vivo role of elevated levels of homocyst(e)ine in the etiology of cardiovascular diseases. ..
  49. Meechan D, Maynard T, Wu Y, Gopalakrishna D, Lieberman J, LaMantia A. Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome. Mol Cell Neurosci. 2006;33:412-28 pubmed
    ..Such changes might contribute to schizophrenia vulnerability in 22q11DS. ..
  50. Grubb B, Rogers T, Kulaga H, Burns K, Wonsetler R, Reed R, et al. Olfactory epithelia exhibit progressive functional and morphological defects in CF mice. Am J Physiol Cell Physiol. 2007;293:C574-83 pubmed
    ..The CF mouse thus provides a novel model to examine the mechanisms of disease-associated loss of olfactory function. ..
  51. Fenton S, Groce N, Lee D. Characterization of the mouse epidermal growth factor promoter and 5'-flanking region. Role for an atypical TATA sequence. J Biol Chem. 1996;271:30870-8 pubmed
    ..These data suggest that the TTTAAA sequence functions as an atypical TATA box. ..
  52. Fruchtman S, Simmons J, Michaylira C, Miller M, Greenhalgh C, Ney D, et al. Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells. Am J Physiol Gastrointest Liver Physiol. 2005;289:G342-50 pubmed
    ....
  53. Ning S, Huye L, Pagano J. Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signaling. J Biol Chem. 2005;280:12262-70 pubmed
    ..A regulatory network between type I IFNs and IRF7 is proposed. The distinct pathways may reflect special roles for an efficient antiviral response at different stages of virus infection. ..
  54. Cogswell P, Kashatus D, Keifer J, Guttridge D, Reuther J, Bristow C, et al. NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J Biol Chem. 2003;278:2963-8 pubmed
    ..These data indicate that the NF-kappa B regulatory pathway exists in mitochondria and that NF-kappa B can negatively regulate mitochondrial mRNA expression. ..
  55. Lazarowski E, Rochelle L, O Neal W, Ribeiro C, Grubb B, Zhang V, et al. Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. J Pharmacol Exp Ther. 2001;297:43-9 pubmed
    ....
  56. Richardson R, Sivashanmugam P, Hall S, Hamil K, Moore P, Ruben S, et al. Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis. Gene. 2001;270:93-102 pubmed
    ..A second family member is predicted to exist on chromosome 20 approximately 4 kb downstream from Eppin's exon I, which has two WAP-type sequences and one Kumtz-type consensus sequence. ..
  57. McMahon E, Cook D, Suzuki K, Matsushima G. Absence of macrophage-inflammatory protein-1alpha delays central nervous system demyelination in the presence of an intact blood-brain barrier. J Immunol. 2001;167:2964-71 pubmed
    ..Nonetheless, despite this possible compensation, our studies show the importance of MIP-1alpha in demyelination in the CNS and highlight its effect, particularly on cellular recruitment and cytokine regulation...
  58. Fogarty M, Xiao R, Prokunina Olsson L, Scott L, Mohlke K. Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK. Hum Mol Genet. 2010;19:1921-9 pubmed publisher
    ..05). These data suggest MMAB is the most likely gene influencing HDL-C levels at this locus and demonstrate that measuring AEI at loci containing more than one candidate gene can prioritize genes for functional studies. ..
  59. Hamil K, Hall S. Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression. Endocrinology. 1994;134:1205-12 pubmed
    ..A 5-kb transcript became detectable by 30 days and decreased after 50 days of age. Ovarian 1.8-kb TSC-22 transcript levels increased about 2-fold during the same maturation period. ..
  60. Xin X, Yang N, Faber J. Platelet-derived growth factor-BB inhibits rat alpha1D-adrenergic receptor gene expression in vascular smooth muscle cells by inducing AP-2-like protein binding to alpha1D proximal promoter region. Mol Pharmacol. 1999;56:1152-61 pubmed
    ..Thus, PDGF-BB may increase AP-2 binding within the proximal promoter to cause down-regulation of alpha1D-AR expression in SMCs when PDGF is elevated, such as in the postnatal growing vascular wall and in vascular hypertrophic diseases. ..
  61. Schliekelman M, Cowley D, O Quinn R, Oliver T, Lu L, Salmon E, et al. Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis. Cancer Res. 2009;69:45-54 pubmed publisher
    ..Thus, Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer. ..
  62. Kuwahara Y, Charboneau A, Knudsen E, Weissman B. Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism. Cancer Res. 2010;70:1854-65 pubmed publisher
    ..These findings indicate that SNF5 mediates a temporally controlled program of cyclin-dependent kinase inhibition to restrict aberrant proliferation in MRT cells. ..