Experts and Doctors on neoplastic cell transformation in New York, United States

Summary

Locale: New York, United States
Topic: neoplastic cell transformation

Top Publications

  1. DePinho R, Hatton K, Tesfaye A, Yancopoulos G, Alt F. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes Dev. 1987;1:1311-26 pubmed
    ..Our analyses clearly prove that L-myc represents a functional member of the myc oncogene family and further delineate structural features that may be important for the common and divergent functions of the members of this gene family. ..
  2. Atchison M, Atchison M, Van Duuren B. Cocarcinogenesis in vitro using Balb/3T3 cells and aromatic hydrocarbon cocarcinogens. Cell Biol Toxicol. 1985;1:323-31 pubmed
    ..All cells isolated from transformed foci showed characteristics of transformed cells including anchorage-independent growth. ..
  3. Rao G, Alland L, Guida P, Schreiber Agus N, Chen K, Chin L, et al. Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1. Oncogene. 1996;12:1165-72 pubmed
  4. Shapiro R, Duquette J, Roses D, Nunes I, Harris M, Kamino H, et al. Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild-type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals. Cancer Res. 1996;56:3597-604 pubmed
    ..We propose that the absence of uPA negatively affects tumorigenesis by decreasing the liberation and availability of growth factors such as basic fibroblast growth factor. ..
  5. Levy D, Gilliland D. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene. 2000;19:2505-10 pubmed
    ..Its role in these cases may be redundant with other transforming events that are in themselves sufficient to cause disease, rendering tyrosine phosphorylation of Stat5 unnecessary in these transformed cells. Oncogene (2000). ..
  6. Marks P, Richon V, Rifkind R. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst. 2000;92:1210-6 pubmed
    ..The hydroxamic acid-based HPCs are potentially effective agents for cancer therapy and, possibly, cancer chemoprevention. ..
  7. Piao C, Hei T. Gene amplification and microsatellite instability induced in tumorigenic human bronchial epithelial cells by alpha particles and heavy ions. Radiat Res. 2001;155:263-267 pubmed
    ..No significant difference in either PALA resistance or microsatellite instability was found in tumor cell lines that were induced by alpha particles compared to those induced by (56)Fe ions. ..
  8. Gaboli M, Kotsi P, Gurrieri C, Cattoretti G, Ronchetti S, Cordon Cardo C, et al. Mzf1 controls cell proliferation and tumorigenesis. Genes Dev. 2001;15:1625-30 pubmed
    ..These findings demonstrate that Mzf1 can act as a tumor/growth suppressor in the hemopoietic compartment. ..
  9. Chen Z, Trotman L, Shaffer D, Lin H, Dotan Z, Niki M, et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 2005;436:725-30 pubmed
    ..Our results demonstrate the relevance of cellular senescence in restricting tumorigenesis in vivo and support a model for cooperative tumour suppression in which p53 is an essential failsafe protein of Pten-deficient tumours. ..

More Information

Publications128 found, 100 shown here

  1. Hessein M, Saad E, Mohamed A, Kamel E, Abdel Hady A, Amina M, et al. Hit-and-run mechanism of HBV-mediated progression to hepatocellular carcinoma. Tumori. 2005;91:241-7 pubmed
    ..Simultaneous investigations of hepatitis B virus integration patterns and genetic changes in precancerous tissues are important to understand the role played by hepatitis B virus integration in hepatocellular caracinoma...
  2. Matula S, Croog V, Itzkowitz S, Harpaz N, Bodian C, Hossain S, et al. Chemoprevention of colorectal neoplasia in ulcerative colitis: the effect of 6-mercaptopurine. Clin Gastroenterol Hepatol. 2005;3:1015-21 pubmed
    ..In UC patients with no initial history of dysplasia, 6MP/AZA use appears to have little or no effect on the rate of neoplastic transformation in the colon. Importantly, the use of 6MP/AZA did not increase malignant transformation in UC. ..
  3. Leslie K, Lang C, Devgan G, Azare J, Berishaj M, Gerald W, et al. Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3. Cancer Res. 2006;66:2544-52 pubmed
    ..These results suggest both a cdk-dependent and cdk-independent role for cyclin D1 in modulating transformation by different oncogenes. ..
  4. Karni R, de Stanchina E, Lowe S, Sinha R, Mu D, Krainer A. The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol. 2007;14:185-93 pubmed
    ..Knockdown of either SF2/ASF or isoform-2 of S6K1 is sufficient to reverse transformation caused by the overexpression of SF2/ASF in vitro and in vivo. Thus, SF2/ASF can act as an oncoprotein and is a potential target for cancer therapy. ..
  5. Yantiss R, Panczykowski A, Misdraji J, Hahn H, Odze R, Rennert H, et al. A comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix. Am J Surg Pathol. 2007;31:1742-53 pubmed
    ..These features, including BRAF mutations, may be more closely related to a serrated morphology in appendiceal polyps rather than biologically important changes...
  6. Mavrakis K, Zhu H, Silva R, Mills J, Teruya Feldstein J, Lowe S, et al. Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes Dev. 2008;22:2178-88 pubmed publisher
    ..Of these, only eIF4E was able to enhance lymphomagenesis in vivo. In summary, the Rheb GTPase is an oncogenic activity upstream of mTORC1 and eIF4E and a direct therapeutic target of farnesyltransferase inhibitors in cancer. ..
  7. Sashida G, Liu Y, Elf S, Miyata Y, Ohyashiki K, Izumi M, et al. ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation. Mol Cell Biol. 2009;29:3687-99 pubmed publisher
    ..Thus, ELF4/MEF promotes tumorigenesis by inhibiting both the p53 and p16/Rb pathways. ..
  8. Wang G, Song J, Wang Z, Dormann H, Casadio F, Li H, et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature. 2009;459:847-51 pubmed publisher
  9. Tang X, Su D, Albert M, Scognamiglio T, Gudas L. Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen. Cancer Biol Ther. 2009;8:1212-3 pubmed
    ..05). Taken together, these data show that overexpression of human LRAT specifically in oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis. ..
  10. Mittal K, Chen F, Wei J, Rijhvani K, Kurvathi R, Streck D, et al. Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas. Mod Pathol. 2009;22:1303-11 pubmed publisher
    ..The immunohistochemical profiles and genetic aberrations of the examined cases suggest that uterine leiomyosarcoma could arise from the preexisting leiomyoma-like areas that often have a symplastic or cellular morphology. ..
  11. Kamino H. Spitzoid melanoma. Clin Dermatol. 2009;27:545-55 pubmed publisher
    ..This contribution provides a review of the clinical presentation, histopathology, ancillary studies, treatment, and the differential diagnosis of spitzoid melanoma. ..
  12. Smilenov L, Brenner D, Hall E. Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells. Cancer Res. 2001;61:5710-3 pubmed
    ..From these data we suggest that Ataxia Telangiectasia heterozygotes could indeed represent a societally-significant radiosensitive human subpopulation. ..
  13. Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe S. Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb Symp Quant Biol. 2008;73:513-22 pubmed publisher
    ..Understanding extracellular cues that regulate these processes may enable new therapies for these conditions. ..
  14. Jong S, Wang L. Two point mutations in the transmembrane domain of P68gag-ros inactive its transforming activity and cause a delay in membrane association. J Virol. 1991;65:180-9 pubmed
    ..Changes of P68TM in the kinetics of membrane association indicate that the transmembrane domain of ros, besides functioning as a membrane anchor, also plays a role in directing initial membrane association. ..
  15. Legouy E, Depinho R, Zimmerman K, Collum R, Yancopoulos G, Mitsock L, et al. Structure and expression of the murine L-myc gene. EMBO J. 1987;6:3359-66 pubmed
    ..We discuss these findings in the context of potential functional domains and the possibility of overlapping and distinct activities of myc-family proteins. ..
  16. Ren R, Ye Z, Baltimore D. Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev. 1994;8:783-95 pubmed
    ..The association of Crk and Abl suggests that Abl could play a role in v-Crk and Crk-I transformation and that normal Abl function may be partly mediated through bound adapter molecules. ..
  17. Polsky D, Bastian B, Hazan C, Melzer K, Pack J, Houghton A, et al. HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma. Cancer Res. 2001;61:7642-6 pubmed
    ..HDM2 amplification occurs infrequently, and other mechanisms that up-regulate HDM2 expression are under investigation. ..
  18. Rosenwald I, Wang S, Savas L, Woda B, Pullman J. Expression of translation initiation factor eIF-2alpha is increased in benign and malignant melanocytic and colonic epithelial neoplasms. Cancer. 2003;98:1080-8 pubmed
  19. Kentsis A, Topisirovic I, Culjkovic B, Shao L, Borden K. Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc Natl Acad Sci U S A. 2004;101:18105-10 pubmed
    ..In all, ribavirin's association with eIF4E may provide a pharmacologic means for the interruption of posttranscriptional networks of oncogenes that maintain and enhance neoplasia and malignancy in human cancer. ..
  20. Wu X. Urothelial tumorigenesis: a tale of divergent pathways. Nat Rev Cancer. 2005;5:713-25 pubmed
    ..Correcting pathway-specific defects represents an attractive strategy for the molecular therapy of urothelial carcinomas. ..
  21. Shuryak I, Ullrich R, Sachs R, Brenner D. The balance between initiation and promotion in radiation-induced murine carcinogenesis. Radiat Res. 2010;174:357-66 pubmed publisher
    ..Also similar to findings in humans, initiation dominates the ERR at young ages in mice, when there are few background pre-malignant cells, and promotion becomes important at older ages. ..
  22. De Keersmaecker K, Real P, Gatta G, Palomero T, Sulis M, Tosello V, et al. The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med. 2010;16:1321-7 pubmed publisher
    ..These results identify a previously unrecognized mechanism contributing to chromosomal missegregation and aneuploidy active at the earliest stages of tumor development in the pathogenesis of cancer. ..
  23. Li G, Ouyang H, Li X, Nagasawa H, Little J, Chen D, et al. Ku70: a candidate tumor suppressor gene for murine T cell lymphoma. Mol Cell. 1998;2:1-8 pubmed
    ..These findings directly demonstrate that Ku70 deficiency facilitates neoplastic growth and suggest a novel role of the Ku70 locus in tumor suppression. ..
  24. Hernández Muñoz I, Malumbres M, Leonardi P, Pellicer A. The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways. Oncogene. 2000;19:2745-57 pubmed
    ..Additional analysis has shown that the activation of this pathway by Rgr is not due to a feed back mechanism mediated by the Grb2 adaptor protein. Oncogene (2000). ..
  25. Xie S, Wu H, Wang Q, Kunicki J, Thomas R, Hollingsworth R, et al. Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2. Cell Cycle. 2002;1:424-9 pubmed
    ..Furthermore, ectopic expression Chk2 activates cellular Plk3. Together, our studies suggest Chk2 may mediate direct activation of Plk3 in response to genotoxic stresses. ..
  26. Topisirovic I, Culjkovic B, Cohen N, Perez J, Skrabanek L, Borden K. The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth. EMBO J. 2003;22:689-703 pubmed
    ..These findings provide a model for regulation of a general factor, eIF4E, in tissue- specific contexts, and suggest that its regulation is important in differentiation and development. ..
  27. Petrenko O, Zaika A, Moll U. deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo. Mol Cell Biol. 2003;23:5540-55 pubmed
    ..Taken together, DeltaNp73 behaves as an oncogene that targets p53 that might explain why DeltaNp73 upregulation may be selected for during tumorigenesis of human cancers. ..
  28. Wendel H, Lowe S. Reversing drug resistance in vivo. Cell Cycle. 2004;3:847-9 pubmed
    ..They also illustrate the importance of tailoring cancer therapy based on tumor genotype. ..
  29. Limnander A, Danial N, Rothman P. v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells. Mol Cell. 2004;15:329-41 pubmed
    ..These findings reveal a mechanism by which Jak-dependent oncogenes may bypass SOCS-1 inhibition. ..
  30. Valdes E, Boolbol S, Cohen J, Feldman S. Malignant transformation of a breast fibroadenoma to cystosarcoma phyllodes: case report and review of the literature. Am Surg. 2005;71:348-53 pubmed
  31. Lasorella A, Iavarone A. The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. Proc Natl Acad Sci U S A. 2006;103:4976-81 pubmed
    ..These data indicate that ENH contributes to differentiation of the nervous system through cytoplasmic sequestration of Id2. They also suggest that ENH is a restraining factor of the oncogenic activity of Id proteins in neural tumors. ..
  32. Bates B, Hardin J, Zhan X, Drickamer K, Goldfarb M. Biosynthesis of human fibroblast growth factor-5. Mol Cell Biol. 1991;11:1840-5 pubmed
    ..FGF-5 is secreted from transfected 3T3 cells and from human tumor cells as glycoproteins containing heterogeneous amounts of sialic acid. Glycosidase treatments suggest that the growth factor bears both N-linked and O-linked sugars. ..
  33. Shi Y, Alin K, Goff S. Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity. Genes Dev. 1995;9:2583-97 pubmed
    ..We suggest that the Abi-1 protein may serve as a regulator of Abl function in transformation or in signal transduction. ..
  34. Mahajan M, Park S, Sun X. Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins. Oncogene. 1996;12:2343-50 pubmed
    ..In rat embryonic fibroblast transformation assays, DRG stimulated the cotransforming activity of c-myc and ras. Based on these results, DRG appears to be a potential target for TAL-like oncoproteins. ..
  35. Lin A, Barradas M, Stone J, Van Aelst L, Serrano M, Lowe S. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev. 1998;12:3008-19 pubmed
    ..Consequently, constitutive MAPK signaling activates p53 and p16 as tumor suppressors. ..
  36. Cong F, Zou X, Hinrichs K, Calame K, Goff S. Inhibition of v-Abl transformation by p53 and p19ARF. Oncogene. 1999;18:7731-9 pubmed
    ..We also show that p53 is not the mediator of v-Abl toxicity in immortal fibroblasts and does not determine the susceptibility of immortal fibroblasts to v-Abl transformation. ..
  37. Cohen N, Sharma M, Kentsis A, Perez J, Strudwick S, Borden K. PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. EMBO J. 2001;20:4547-59 pubmed
    ..PML is the first factor shown to modulate nuclear eIF4E function. These findings provide the first biochemical framework for understanding the transformation suppression activity of PML. ..
  38. Hernando E, Charytonowicz E, Dudas M, Menendez S, Matushansky I, Mills J, et al. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med. 2007;13:748-53 pubmed
  39. Koppikar P, Levine R. JAK2 and MPL mutations in myeloproliferative neoplasms. Acta Haematol. 2008;119:218-25 pubmed publisher
    ..In this review, we will discuss the genetics of PV, ET and PMF with regard to known somatic mutations, the role of these mutations in hematopoietic transformation and the therapeutic implications of these findings. ..
  40. Kluwe J, Mencin A, Schwabe R. Toll-like receptors, wound healing, and carcinogenesis. J Mol Med (Berl). 2009;87:125-38 pubmed publisher
  41. Gough D, Corlett A, Schlessinger K, Wegrzyn J, Larner A, Levy D. Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science. 2009;324:1713-6 pubmed publisher
    ..Thus, in addition to its nuclear transcriptional role, STAT3 regulates a metabolic function in mitochondria, supporting Ras-dependent malignant transformation. ..
  42. Gardner L. Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis. Mol Cancer Res. 2010;8:295-308 pubmed publisher
  43. Li W, Hu P, Skolnik E, Ullrich A, Schlessinger J. The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors. Mol Cell Biol. 1992;12:5824-33 pubmed
    ..Nck probably functions as an adaptor protein which links surface receptors with tyrosine kinase activity to downstream signalling pathways involved in the control of cell proliferation. ..
  44. Serrano M, Lee H, Chin L, Cordon Cardo C, Beach D, DePinho R. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996;85:27-37 pubmed
    ..These findings directly demonstrate that the INK4a locus functions to suppress neoplastic growth. ..
  45. Chiarle R, Gong J, Guasparri I, Pesci A, Cai J, Liu J, et al. NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. Blood. 2003;101:1919-27 pubmed
    ..Our NPM-ALK Tg mice are a suitable model to dissect the molecular mechanisms of ALK-mediated transformation and to investigate the efficacy of new therapeutic approaches for the treatment of human ALCL in vivo. ..
  46. Oki S, Limnander A, Yao P, Niki M, Pandolfi P, Rothman P. Dok1 and SHIP act as negative regulators of v-Abl-induced pre-B cell transformation, proliferation and Ras/Erk activation. Cell Cycle. 2005;4:310-4 pubmed
    ..These data indicate that both SHIP and Dok1 functionally regulate the activation of Ras-Erk pathway by v-Abl and affect the mitogenic activity of v-Abl transformed bone marrow cells. ..
  47. Salm S, Burger P, Coetzee S, Goto K, Moscatelli D, Wilson E. TGF-{beta} maintains dormancy of prostatic stem cells in the proximal region of ducts. J Cell Biol. 2005;170:81-90 pubmed
    ..In addition to highlighting the regulatory role of androgens and TGF-beta, these findings may have important implications for the deregulation of the stem cell compartment in the etiology of proliferative prostatic diseases. ..
  48. Wurmbach E, Chen Y, Khitrov G, Zhang W, Roayaie S, Schwartz M, et al. Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology. 2007;45:938-47 pubmed
    ..These findings provide a comprehensive molecular portrait of genomic changes in progressive HCV-related HCC. ..
  49. Braunstein S, Formenti S, Schneider R. Acquisition of stable inducible up-regulation of nuclear factor-kappaB by tumor necrosis factor exposure confers increased radiation resistance without increased transformation in breast cancer cells. Mol Cancer Res. 2008;6:78-88 pubmed publisher
    ..Greater cell survival despite increased genomic injury may permit increased acquisition of malignant genetic alterations as well as resistance to chemoradiation therapy. ..
  50. Yang K, Popova N, Yang W, Lozonschi I, Tadesse S, Kent S, et al. Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. Cancer Res. 2008;68:7313-22 pubmed publisher
    ..We hypothesize that Muc2(-/-) tumors develop through an inflammation-related pathway that is distinct from and can complement mechanisms of tumorigenesis in Apc(+/-) mice...
  51. Jiang H, Su Z, Lin J, Goldstein N, Young C, Fisher P. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc Natl Acad Sci U S A. 1996;93:9160-5 pubmed
  52. Kourea H, Cordon Cardo C, Dudas M, Leung D, Woodruff J. Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27(kip) in malignant transformation of neurofibromas. Am J Pathol. 1999;155:1885-91 pubmed
    ..001). Furthermore, detection of cytoplasmic p27 expression was found to be a prognostic factor for poor survival in MPNSTs (P = 0.03, relative risk = 2.4). ..
  53. Ma J, Takito J, Vijayakumar S, Peehl D, Olsson C, Al Awqati Q. Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation. Prostate. 2001;49:9-18 pubmed
    ..The localization of hensin/DMBT1 during maturation raises the possibility that hensin/DMBT1 is involved in terminal differentiation of the prostate and vas deferens. ..
  54. Connolly E, Melegari M, Landgraf P, Tchaikovskaya T, Tennant B, Slagle B, et al. Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol. 2008;173:856-64 pubmed publisher
    ..The combination of assays presented here supports a role for these miRNAs in the maintenance of the malignant transformation of hepatocytes. ..
  55. Frescas D, Guardavaccaro D, Kuchay S, Kato H, Poleshko A, Basrur V, et al. KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle. 2008;7:3539-47 pubmed
    ..Since the disruption of epigenetic control mechanisms contributes to cellular transformation, these results, together with the low levels of KDM2A found in prostate carcinomas, suggest a role for KDM2A in cancer development. ..
  56. Pan W, da Graca L, Shao Y, Yin Q, Wu H, Jiang X. PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis. J Biol Chem. 2009;284:6946-54 pubmed publisher
    ..Disruption of the nuclear localization signal of PHAPI caused a modest decrease of its tumor-suppressive function, indicating that nuclear localization of PHAPI contributes to, but is not essential for, tumor suppression. ..
  57. Li N, Yang R, Zhang W, Dorfman H, Rao P, Gorlick R. Genetically transforming human mesenchymal stem cells to sarcomas: changes in cellular phenotype and multilineage differentiation potential. Cancer. 2009;115:4795-806 pubmed publisher
    ..High-grade osteosarcomas frequently demonstrate the potential for multipotent differentiation and, along with several other lines of evidence, suggest that human mesenchymal stem cells (hMSC) might be the cell of origin...
  58. Sorrentino V, McKinney M, Drozdoff V, Hume C, Fleissner E. Spontaneous or carcinogen-mediated amplification of a mutated ras gene promotes neoplastic transformation. Oncogene Res. 1988;2:189-95 pubmed
    ..The data reported here indicate that a chemical agent that modifies DNA structure can enhance the frequency of amplification events in cellular DNA and, by affecting ras copy number, promote cell transformation...
  59. Zhan X, Bates B, Hu X, Goldfarb M. The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors. Mol Cell Biol. 1988;8:3487-95 pubmed
    ..The rearrangement which activated the FGF-5 gene during DNA transfection had juxtaposed a retrovirus transcriptional enhancer just upstream from the native promoter of the gene. ..
  60. Morrison M, Vijayasaradhi S, Engelstein D, Albino A, Houghton A. A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase. J Exp Med. 1993;177:1135-43 pubmed
    ..These findings show that ADAbp is a cell surface ectopeptidase that is tightly regulated during neoplastic transformation of melanocytes. ..
  61. Zhou W, Parent L, Wills J, Resh M. Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids. J Virol. 1994;68:2556-69 pubmed
    ..We propose that the N-terminal Gag sequence functions as a targeting signal to direct interaction with acidic phospholipids on the cytoplasmic leaflet of the plasma membrane. ..
  62. Chesi M, Nardini E, Lim R, Smith K, Kuehl W, Bergsagel P. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood. 1998;92:3025-34 pubmed
    ..This is the first example of an IgH translocation that simultaneously dysregulates two genes with oncogenic potential: FGFR3 on der(14) and MMSET on der(4). ..
  63. Movilla N, Crespo P, Bustelo X. Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins. Oncogene. 1999;18:5860-9 pubmed
    ..From these results, we conclude that TC21 promotes Ras-like responses in diverse cell types due to the use of overlapping, if not identical, signaling elements of the Ras oncogenic pathway. ..
  64. Lezon Geyda K, Najfeld V, Johnson E. Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia. Leukemia. 2001;15:954-62 pubmed
    ..Alterations in these genes could affect a delicate balance critical in myeloid development. ..
  65. Katdare M, Osborne M, Telang N. Novel cell culture models for prevention of human breast cancer (Review). Int J Oncol. 2003;22:509-15 pubmed
  66. Mutlu A, Cavallin L, Vincent L, Chiozzini C, Eroles P, Duran E, et al. In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell. 2007;11:245-58 pubmed
    ..These results show that KSHV malignancy is in vivo growth restricted and reversible, defining mECK36 as a biologically sensitive animal model of KSHV-dependent KS...
  67. Wendel H, Silva R, Malina A, Mills J, Zhu H, Ueda T, et al. Dissecting eIF4E action in tumorigenesis. Genes Dev. 2007;21:3232-7 pubmed
    ..Our results provide insight into how eIF4E contributes to tumorigenesis and pinpoint a level of translational control that may be suitable for therapeutic intervention. ..
  68. Resh M. The ups and downs of SRC regulation: tumor suppression by Cbp. Cancer Cell. 2008;13:469-71 pubmed publisher
    ..However, the authors show that Cbp-mediated Src suppression is Csk independent. These findings suggest that Cbp is a tumor suppressor whose expression is downregulated during Src-driven cancer progression. ..
  69. Sangodkar J, Shi J, Difeo A, Schwartz R, Bromberg R, Choudhri A, et al. Functional role of the KLF6 tumour suppressor gene in gastric cancer. Eur J Cancer. 2009;45:666-76 pubmed publisher
  70. Jankovic M, Robbiani D, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, et al. Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proc Natl Acad Sci U S A. 2010;107:187-92 pubmed publisher
    ..We conclude that AID-induced double-strand breaks in non-Ig genes other than c-myc lead to their translocation, and that at least two nonoverlapping pathways protect against translocations in primary B cells. ..
  71. Abdel Wahab O, Manshouri T, Patel J, Harris K, Yao J, Hedvat C, et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res. 2010;70:447-52 pubmed publisher
    ..Given the presence of sAML that have no preexisting JAK2/TET2/ASXL1/IDH1 mutations, our work indicates the existence of other mutations yet to be identified that are necessary for leukemic transformation. ..
  72. Castillo Martin M, Domingo Domenech J, Karni Schmidt O, Matos T, Cordon Cardo C. Molecular pathways of urothelial development and bladder tumorigenesis. Urol Oncol. 2010;28:401-8 pubmed publisher
    ..Neither urothelial stem cells nor bladder cancer stem cells have been identified to date. In this review, we will further expand on the issues discussed above. ..
  73. Paietta E, Stockert R, Racevskis J. Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver. Hepatology. 1992;15:395-402 pubmed
  74. Schwartzberg P, Robertson E, Goff S. Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein. Proc Natl Acad Sci U S A. 1990;87:3210-4 pubmed
    ..Direct screening of genomic DNAs showed that a high proportion of drug-resistant clones arose from homologous recombination into the endogenous c-abl locus. ..
  75. Zou X, Cong F, Coutts M, Cattoretti G, Goff S, Calame K. p53 deficiency increases transformation by v-Abl and rescues the ability of a C-terminally truncated v-Abl mutant to induce pre-B lymphoma in vivo. Mol Cell Biol. 2000;20:628-33 pubmed
  76. Gopalkrishnan R, Roberts T, Tuli S, Kang D, Christiansen K, Fisher P. Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. Oncogene. 2000;19:4405-16 pubmed
  77. Leonardi P, Kassin E, Hernández Muñoz I, Diaz R, Inghirami G, Pellicer A. Human rgr: transforming activity and alteration in T-cell malignancies. Oncogene. 2002;21:5108-16 pubmed
    ..These findings also raise the possibility that mutations in the hrgr gene are involved in other malignancies. ..
  78. Yilmaz A, Rush D, Soslow R. Endometrial stromal sarcomas with unusual histologic features: a report of 24 primary and metastatic tumors emphasizing fibroblastic and smooth muscle differentiation. Am J Surg Pathol. 2002;26:1142-50 pubmed
  79. Cesarman E, Mesri E. Pathogenesis of viral lymphomas. Cancer Treat Res. 2006;131:49-88 pubmed
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