Genomes and Genes
Experts and Doctors on mice in New York, United States
Locale: New York, United States
Publications522 found, 100 shown here
- Fernández Romero J, Abraham C, Rodriguez A, Kizima L, Jean Pierre N, Menon R, et al. Zinc acetate/carrageenan gels exhibit potent activity in vivo against high-dose herpes simplex virus 2 vaginal and rectal challenge. Antimicrob Agents Chemother. 2012;56:358-68 pubmed publisher..Our results provide a strong rationale to further optimize and evaluate the zinc acetate/carrageenan gels for their ability to block the sexual transmission of HIV and HSV-2...
- Che F, Yuan Q, Kalinina E, Fricker L. Peptidomics of Cpe fat/fat mouse hypothalamus: effect of food deprivation and exercise on peptide levels. J Biol Chem. 2005;280:4451-61 pubmed..Taken together, the differential regulation of these peptides in the two paradigms suggests that the regulation is not due to the lower body weight but to the manner in which the paradigms achieved this lower body weight. ..
- Petri S, Kiaei M, Wille E, Calingasan N, Flint Beal M. Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice. J Neurol Sci. 2006;251:44-9 pubmed..These results indicate that motor neuron apoptosis triggered by Fas is relevant in ALS pathogenesis. ..
- Duffy H, Iacobas I, Hotchkiss K, Hirst Jensen B, Bosco A, Dandachi N, et al. The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. J Biol Chem. 2007;282:9789-96 pubmed..Together, these results suggest that loss of Cx32 alters the levels, localization, and interactions of the tumor suppressor protein Dlgh1, events known in other systems to alter cell cycle and increase tumorigenicity. ..
- Hang H, Wilson J, Charron G. Bioorthogonal chemical reporters for analyzing protein lipidation and lipid trafficking. Acc Chem Res. 2011;44:699-708 pubmed publisher..Future advances in bioorthogonal chemistry, specific lipid reporters, and spectroscopy should provide important new insight into the functional roles of lipidated proteins and membranes in biology. ..
- Xiao A, Li H, Shechter D, Ahn S, Fabrizio L, Erdjument Bromage H, et al. WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature. 2009;457:57-62 pubmed publisher..Our work demonstrates a new mechanism that regulates the DNA damage response and expands our knowledge of domains that contain intrinsic tyrosine kinase activity. ..
- Liston C, Cichon J, Jeanneteau F, Jia Z, Chao M, Gan W. Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nat Neurosci. 2013;16:698-705 pubmed publisher..They also delineate a new signaling mechanism underlying these effects. ..
- Spigelman M. New tuberculosis therapeutics: a growing pipeline. J Infect Dis. 2007;196 Suppl 1:S28-34 pubmed..In addition, novel targets have been identified and are the subject of efforts to validate their potential usefulness in the treatment of TB. ..
- Yin F, Dumont M, Banerjee R, Ma Y, Li H, Lin M, et al. Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia. FASEB J. 2010;24:4639-47 pubmed publisher..Thus, progranulin deficiency induced FTD-like behavioral and neuropathological deficits. These mice may serve as an important tool for deciphering underlying mechanisms in frontotemporal dementia. ..
- Ferrero E, Hsieh C, Francke U, Goyert S. CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes. J Immunol. 1990;145:331-6 pubmed..The inclusion of CD14 in the family of leucine-rich proteins, its expression profile and the murine chromosomal localization support the hypothesis that CD14 may function as a receptor. ..
- Scherer T, O Hare J, DIGGS ANDREWS K, Schweiger M, Cheng B, Lindtner C, et al. Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab. 2011;13:183-94 pubmed publisher..Conversely, mice that lack the neuronal insulin receptor exhibit unrestrained lipolysis and decreased de novo lipogenesis in WAT. Thus, brain and, in particular, hypothalamic insulin action play a pivotal role in WAT functionality. ..
- Bechmann L, Gastaldelli A, Vetter D, Patman G, Pascoe L, Hannivoort R, et al. Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease. Hepatology. 2012;55:1083-93 pubmed publisher..KLF6 regulation of GCK contributes to the development of hepatic insulin resistance. The KLF6-IVS1-27A polymorphism, which generates more KLF6-SV1, combats this, lowering hepatic insulin resistance and blood glucose. ..
- Cao X, Peterson J, Wang G, Anrather J, Young C, Guruju M, et al. Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain. Hypertension. 2012;59:869-76 pubmed publisher..Thus, COX 1-derived PGE(2) signaling through EP(1)R in the SFO is required for the ROS-mediated HTN induced by systemic infusion of Ang II and suggests that EP(1)R in the SFO may provide a novel target for antihypertensive therapy. ..
- Sato N, Brivanlou A. Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor. Methods Mol Biol. 2006;331:115-28 pubmed..These approaches will become a fundamental platform to identify molecular networks regulating cell fate determination in hESCs and mouse embryonic stem cells. ..
- Ono K, Ye Y, Viet C, Dang D, Schmidt B. TRPV1 expression level in isolectin Bâ‚„-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity. J Neurophysiol. 2015;113:3345-55 pubmed publisher..These results suggest that TRPV1 expression levels in IB4-positive type 2 and 13 neurons contributed to differential thermal nociception in skin of C57BL/6 compared with BALB/c. ..
- Massa P, Li X, Hanidu A, Siamas J, Pariali M, Pareja J, et al. Gene expression profiling in conjunction with physiological rescues of IKKalpha-null cells with wild type or mutant IKKalpha reveals distinct classes of IKKalpha/NF-kappaB-dependent genes. J Biol Chem. 2005;280:14057-69 pubmed
- Dai Q, Choy E, Chiu V, Romano J, Slivka S, Steitz S, et al. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem. 1998;273:15030-4 pubmed..Thus, the final enzyme in the sequence that modifies CAAX motifs is located in membranes topologically removed from the CAAX protein target membrane. ..
- Cho S, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z. TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage. Mol Cell Biol. 2001;21:8398-413 pubmed
- Hong S, Momcilovic M, Carlson M. Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast. J Biol Chem. 2005;280:21804-9 pubmed..Finally, this analysis provided evidence that Pak1 functions in another capacity, besides activating Snf1, to regulate the nuclear enrichment of Snf1 protein kinase in response to carbon stress. ..
- Petros T, Williams S, Mason C. Temporal regulation of EphA4 in astroglia during murine retinal and optic nerve development. Mol Cell Neurosci. 2006;32:49-66 pubmed
- Javitt N. Oxysterols: functional significance in fetal development and the maintenance of normal retinal function. Curr Opin Lipidol. 2007;18:283-8 pubmed..This review shifts the focus of attention from studies of their ligand-binding activity to studies of animal models that indicate a number of important biologic effects during fetal development and during the aging process. ..
- Nobile C, Solis N, Myers C, Fay A, Deneault J, Nantel A, et al. Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions. Cell Microbiol. 2008;10:2180-96 pubmed publisher..Four of these five genes govern cell wall structure. Our results indicate that Rim101-dependent cell wall alteration contributes to C. albicans pathogenic interactions with oral epithelial cells, independently of cell morphology...
- Lemos M, McKinney J, Rhee K. Dispensability of surfactant proteins A and D in immune control of Mycobacterium tuberculosis infection following aerosol challenge of mice. Infect Immun. 2011;79:1077-85 pubmed publisher..tuberculosis were unaltered in all genotypes tested. Together, these data indicate that SP-A and SP-D are dispensable for immune control of M. tuberculosis in a low-dose, aerosol challenge, murine model of tuberculosis (TB). ..
- Pan Y, Xu J, Pasternak G. Structure and characterization of the gene encoding a mouse kappa3-related opioid receptor. Gene. 1996;171:255-60 pubmed..A putative poly(A) signal (AATAAA) is found in the 3'-flanking region. ..
- Santoro B, Liu D, Yao H, Bartsch D, Kandel E, Siegelbaum S, et al. Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998;93:717-29 pubmed
- Kelley K, Ho L, Winger D, Freire Moar J, Borelli C, Aisen P, et al. Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2. Am J Pathol. 1999;155:995-1004 pubmed..This model system will allow the systematic examination of the role of COX-2 in mechanisms of neurodegeneration that involve excitatory amino acid pathways. ..
- Li B, Ishii T, Tan C, Soh J, Goff S. Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C. J Biol Chem. 2002;277:12418-22 pubmed
- Francis S, Shen X, Young J, Kaul P, Lerner D. Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood. 2006;107:1627-35 pubmed..These results demonstrate that Lsc links formyl-peptide receptors to RhoA signaling pathways that regulate polarization, migration, and adhesion in neutrophils and that Lsc is required for leukocyte homeostasis. ..
- Li M, Mruk D, Cheng C. Gap junctions and blood-tissue barriers. Adv Exp Med Biol. 2012;763:260-80 pubmed
- Shen C, Yuan P, Perez Lorenzo R, Zhang Y, Lee S, Ou Y, et al. Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation. Mol Cell. 2013;52:161-72 pubmed publisher..Our findings reveal a mechanism for regulating BRAF signaling in response to energy stress and suggest a strategy for preventing the development of cSCCs associated with BRAF-targeted therapy. ..
- Batourina E, Choi C, Paragas N, Bello N, Hensle T, Costantini F, et al. Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat Genet. 2002;32:109-15 pubmed..Our studies indicate that formation of the trigonal wedge may be essential for correct insertion of the distal ureters into the bladder, and that these events are mediated by the vitamin A and Ret signaling pathways. ..
- Higgins J, Tal A, Sun X, Hauck S, Hao J, Kosofosky B, et al. Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence. J Neurogenet. 2010;24:18-26 pubmed publisher..The results suggest that mutCRBN may cause ARNSID by disrupting the developmental regulation of BK(Ca) in brain regions that are critical for memory and learning. ..
- Mierzwa A, Shroff S, Rosenbluth J. Permeability of the paranodal junction of myelinated nerve fibers. J Neurosci. 2010;30:15962-8 pubmed publisher..This pathway may also allow access of antibodies and toxic molecules to the internodal axon in paraneoplastic syndromes and demyelinating diseases...
- Shamovsky I, Ivannikov M, Kandel E, Gershon D, Nudler E. RNA-mediated response to heat shock in mammalian cells. Nature. 2006;440:556-60 pubmed..The central role of HSR1 during heat shock implies that targeting this RNA could serve as a new therapeutic model for cancer, inflammation and other conditions associated with HSF1 deregulation. ..
- Benach J, Wang L, Chen Y, Ho C, Lee S, Seetharaman J, et al. Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus 68. J Biol Chem. 2007;282:31534-41 pubmed..The results of the functional studies are fully consistent with the structural observations and indicate that the N-terminal alpha-helix is a crucial site of interaction for ORF52. ..
- Giliberto L, Matsuda S, Vidal R, D ADAMIO L. Generation and initial characterization of FDD knock in mice. PLoS ONE. 2009;4:e7900 pubmed publisher..This new murine mouse model will be important to further understand the interaction between APP and BRI(2), and to provide insights into the molecular basis of FDD. ..
- Herrera E, Marcus R, Li S, Williams S, Erskine L, Lai E, et al. Foxd1 is required for proper formation of the optic chiasm. Development. 2004;131:5727-39 pubmed
- Lim J, Berezniuk I, Che F, Parikh R, Biswas R, Pan H, et al. Altered neuropeptide processing in prefrontal cortex of Cpe (fat/fat) mice: implications for neuropeptide discovery. J Neurochem. 2006;96:1169-81 pubmed
- Melana S, Nepomnaschy I, Hasa J, Djougarian A, Djougarian A, Holland J, et al. Detection of human mammary tumor virus proteins in human breast cancer cells. J Virol Methods. 2010;163:157-61 pubmed publisher..This should be taken into consideration when MMTV antibodies are used to detect HMTV proteins in human tissues. ..
- Oskarsson T, Nagorny P, Krauss I, Perez L, Mandal M, Yang G, et al. Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. J Am Chem Soc. 2010;132:3224-8 pubmed publisher..Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells. ..
- Yoburn B, Gomes B, Rajashekara V, Patel C, Patel M. Role of G(i)alpha2-protein in opioid tolerance and mu-opioid receptor downregulation in vivo. Synapse. 2003;47:109-16 pubmed..Overall, these results support an important role for G((i)alpha2)-protein in the acute effects of opioids and opioid tolerance. However, G((i)alpha2) is not required for agonist-induced mu-opioid receptor density regulation in vivo. ..
- Chang J, Wendt T, Qu W, Kong L, Zou Y, Schmidt A, et al. Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ Res. 2008;102:905-13 pubmed publisher..These findings identify RAGE as a master regulator of tissue stress elicited by hypoxia and highlight this receptor as a central therapeutic target to suppress the tissue injury-provoking effects of oxygen deprivation. ..
- Drew K, Winters P, Butterfoss G, Berstis V, Uplinger K, Armstrong J, et al. The Proteome Folding Project: proteome-scale prediction of structure and function. Genome Res. 2011;21:1981-94 pubmed publisher..We demonstrate that predicted structures can be combined with annotations from the Gene Ontology database to predict new and more specific molecular functions. ..
- Guijarro M, Dahiya S, Danielson L, Segura M, Vales Lara F, Menendez S, et al. Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling. Am J Pathol. 2013;182:2015-27 pubmed publisher..Our results highlight the importance of molecularly subclassifying patients with high-grade sarcoma for targeted treatments. ..
- Lee H, Xu H, Nasr S, Schnermann J, Emala C. A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion. Am J Physiol Renal Physiol. 2004;286:F298-306 pubmed..In conclusion, we demonstrate that endogenous or exogenous preischemic activation of A1 ARs protects against renal I/R injury in vivo via mechanisms leading to decreased necrosis and inflammation. ..
- Yoshida H, Bao L, Kefaloyianni E, Taşkın E, Okorie U, Hong M, et al. AMP-activated protein kinase connects cellular energy metabolism to KATP channel function. J Mol Cell Cardiol. 2012;52:410-8 pubmed publisher..During metabolic stress, a small change in cellular AMP that activates AMPK can be a potential trigger for K(ATP) channel opening. This article is part of a Special Issue entitled "Local Signaling in Myocytes". ..
- Voigt P, LeRoy G, Drury W, Zee B, Son J, Beck D, et al. Asymmetrically modified nucleosomes. Cell. 2012;151:181-93 pubmed publisher..These findings uncover a potential mechanism for the incorporation of bivalent features into nucleosomes and demonstrate how asymmetry might set the stage to diversify functional nucleosome states...
- Skariah S, Mordue D. Identification of Toxoplasma gondii genes responsive to the host immune response during in vivo infection. PLoS ONE. 2012;7:e46621 pubmed publisher..Many of the parasite genes increased in vivo appear to be common to an early general stress response by the parasite; surprisingly putative oocyst stage specific genes were also disproportionately increased during infection. ..
- Bisikirska B, Adam S, Alvarez M, Rajbhandari P, Cox R, Lefebvre C, et al. STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma. Oncogene. 2013;32:5283-91 pubmed publisher..Moreover, STK38 knockdown suppresses growth of MYC-addicted tumors in vivo, thus providing a novel viable target for treating these malignancies. ..
- Rommel P, Oliveira T, Nussenzweig M, Robbiani D. RAG1/2 induces genomic insertions by mobilizing DNA into RAG1/2-independent breaks. J Exp Med. 2017;214:815-831 pubmed publisher..Our findings reveal a novel RAG1/2-mediated insertion pathway distinct from DNA transposition and trans-V(D)J recombination that destabilizes the genome and shares features with reported oncogenic DNA insertions. ..
- Roy K, Mitsugi K, Sirlin S, Shane B, Sirotnak F. Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription. J Biol Chem. 1995;270:26918-22 pubmed..These results provide the first examples of constitutively altered transcriptional regulation of FPGS activity associated with acquired resistance to antifolates. ..
- Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S. Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele. Am J Physiol. 1997;273:E743-50 pubmed
- Gutierrez Juarez R, Pocai A, Mulas C, Ono H, Bhanot S, Monia B, et al. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J Clin Invest. 2006;116:1686-95 pubmed..Thus, Scd1 is required for the onset of diet-induced hepatic insulin resistance. ..
- Lee M, Kim A, Chua S, Obici S, Wardlaw S. Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. Am J Physiol Endocrinol Metab. 2007;293:E121-31 pubmed..Our results suggest that long-term melanocortinergic activation could serve as a potential strategy for the treatment of obesity and its deleterious metabolic consequences. ..
- Cortes Canteli M, Paul J, Norris E, Bronstein R, Ahn H, Zamolodchikov D, et al. Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease. Neuron. 2010;66:695-709 pubmed publisher..These experiments suggest that one important contribution of Abeta to AD is via its effects on fibrin clots, implicating fibrin(ogen) as a potential critical factor in this disease. ..
- Kabir Z, Lourenco F, Byrne M, Katzman A, Lee F, Rajadhyaksha A, et al. Brain-derived neurotrophic factor genotype impacts the prenatal cocaine-induced mouse phenotype. Dev Neurosci. 2012;34:184-97 pubmed..Such findings in our prenatal cocaine mouse model suggest a gene X environment interaction of potential clinical relevance. ..
- Witkovsky P, Veisenberger E, LeSauter J, Yan L, Johnson M, Zhang D, et al. Cellular location and circadian rhythm of expression of the biological clock gene Period 1 in the mouse retina. J Neurosci. 2003;23:7670-6 pubmed..Our results are the first to demonstrate a circadian rhythm of a biological clock component in identified neurons of a mammalian retina. ..
- Jaferi A, Pickel V. Mu-opioid and corticotropin-releasing-factor receptors show largely postsynaptic co-expression, and separate presynaptic distributions, in the mouse central amygdala and bed nucleus of the stria terminalis. Neuroscience. 2009;159:526-39 pubmed publisher..The commonalities in the synaptic location of both receptors in the CeA and BNST suggest that this is a fundamental cellular association of relevance to both drug addiction and stress-induced disorders. ..
- Wang X, Kruithof de Julio M, Economides K, Walker D, Yu H, Halili M, et al. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature. 2009;461:495-500 pubmed publisher..These observations indicate that CARNs represent a new luminal stem cell population that is an efficient target for oncogenic transformation in prostate cancer. ..
- CHALAZONITIS A, D Autréaux F, Pham T, Kessler J, Gershon M. Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling. Dev Biol. 2011;350:64-79 pubmed publisher..These observations support the hypotheses that BMPs are required for enteric gliogenesis and act by promoting responsiveness of ENCDC to ErbB3 ligands such as GGF2. ..
- Singh D, Chan J, Zoppoli P, Niola F, Sullivan R, Castaño A, et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science. 2012;337:1231-5 pubmed publisher..FGFR-TACC fusions could potentially identify a subset of GBM patients who would benefit from targeted FGFR kinase inhibition...
- Sharma A, Krause A, Xu Y, Sung B, Wu W, Worgall S. Adenovirus-based vaccine with epitopes incorporated in novel fiber sites to induce protective immunity against Pseudomonas aeruginosa. PLoS ONE. 2013;8:e56996 pubmed publisher..F(FG)Epi8 or AdZ.F(HI)Epi8, but not with AdOprF, induced protective immunity against P. aeruginosa. This suggests that incorporation of epitopes into distinct sites of the Ad fiber is a promising vaccine strategy. ..
- Jho E, Zhang T, Domon C, Joo C, Freund J, Costantini F. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol. 2002;22:1172-83 pubmed..Our results suggest that Axin2 participates in a negative feedback loop, which could serve to limit the duration or intensity of a Wnt-initiated signal. ..
- He X, Okino N, Dhami R, Dagan A, Gatt S, Schulze H, et al. Purification and characterization of recombinant, human acid ceramidase. Catalytic reactions and interactions with acid sphingomyelinase. J Biol Chem. 2003;278:32978-86 pubmed..These studies provide new insights into acid ceramidase and the related lipid hydrolase, acid sphingomyelinase. ..
- Ge C, Liu T, Hou X, Stanley P. In vivo consequences of deleting EGF repeats 8-12 including the ligand binding domain of mouse Notch1. BMC Dev Biol. 2008;8:48 pubmed publisher..While Notch1 is expressed in oocytes and blastocysts, Notch1 signaling via canonical ligands is dispensable during oogenesis, blastogenesis, implantation and gastrulation. ..
- Ipsaro J, Haase A, Knott S, Joshua Tor L, Hannon G. The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Nature. 2012;491:279-83 pubmed publisher..Together, our data suggest that the Zucchini proteins act in primary piRNA biogenesis as nucleases, perhaps generating the 5' ends of primary piRNAs. ..
- Micsenyi M, Sikora J, Stephney G, Dobrenis K, Walkley S. Lysosomal membrane permeability stimulates protein aggregate formation in neurons of a lysosomal disease. J Neurosci. 2013;33:10815-27 pubmed publisher..Furthermore, we offer a novel role for p62 in response to LMP that may be relevant for other diseases exhibiting p62 accumulation. ..
- Bogdan C, Alexander A, Gorny M, Matute R, Marjanovic N, Zolla Pazner S, et al. Chronic lymphocytic leukemia with prostate infiltration mediated by specific clonal membrane-bound IgM. Cancer Res. 2003;63:2067-71 pubmed
- Silva R, Ries V, Oo T, Yarygina O, Jackson Lewis V, Ryu E, et al. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem. 2005;95:974-86 pubmed..We conclude that the role of CHOP depends on the nature of the toxic stimulus. For 6OHDA, an oxidative metabolite of dopamine, it is a mediator of apoptotic death. ..
- Lin E, Li J, Gnatovskiy L, Deng Y, Zhu L, Grzesik D, et al. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 2006;66:11238-46 pubmed..Taken together, this study shows that tumor-associated macrophages play a key role in promoting tumor angiogenesis, an essential step in the tumor progression to malignancy. ..
- Green D, Karpatkin S. Role of thrombin as a tumor growth factor. Cell Cycle. 2010;9:656-61 pubmed
- Ekland E, Schneider J, Fidock D. Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches. FASEB J. 2011;25:3583-93 pubmed publisher..These assays provide the foundation for high-throughput campaigns to identify novel chemotypes for combination therapies to treat multidrug-resistant malaria. ..
- Doege C, Inoue K, Yamashita T, Rhee D, Travis S, Fujita R, et al. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature. 2012;488:652-5 pubmed publisher..These findings suggest that Parp1 and Tet2 contribute to an epigenetic program that directs subsequent transcriptional induction at pluripotency loci during somatic cell reprogramming. ..
- Alpdogan O, Schmaltz C, Muriglan S, Kappel B, Perales M, Rotolo J, et al. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood. 2001;98:2256-65 pubmed..In conclusion, posttransplant IL-7 administration to recipients of an allogeneic BMT enhances lymphoid reconstitution without aggravating GVHD while preserving GVL. ..
- Shaffer D, Viale A, Ishiwata R, Leversha M, Olgac S, Manova K, et al. Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate. Proc Natl Acad Sci U S A. 2005;102:210-5 pubmed..These experiments provide direct physiological and causal evidence that p27 has tumor suppressive functions independent of its role regulating cell proliferation. ..
- Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov A, et al. Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell. 2013;154:748-62 pubmed publisher..Our structural and functional analysis highlights the unexpected versatility of STING in the recognition of natural and synthetic ligands within a small-molecule pocket created by the dimerization of STING. ..
- Katayama Y, Battista M, Kao W, Hidalgo A, Peired A, Thomas S, et al. Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell. 2006;124:407-21 pubmed..Further, administration of a beta(2) adrenergic agonist enhances mobilization in both control and NE-deficient mice. Thus, these results indicate that the sympathetic nervous system regulates the attraction of stem cells to their niche...
- Ahamed J, Burg N, Yoshinaga K, Janczak C, Rifkin D, Coller B. In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1. Blood. 2008;112:3650-60 pubmed publisher..Release and activation of latent TGF-beta1 in vivo was demonstrated in a mouse model 5 minutes after thrombus formation. These data potentially provide a novel mechanism for in vivo activation of TGF-beta1. ..