Genomes and Genes
Experts and Doctors on animals in New York, United States
Locale: New York, United States
Publications1918 found, 100 shown here
- Klivenyi P, Calingasan N, Starkov A, Stavrovskaya I, Kristal B, Yang L, et al. Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase. Neurobiol Dis. 2004;15:610-7 pubmed
- Zhang Z, Krainer A. Involvement of SR proteins in mRNA surveillance. Mol Cell. 2004;16:597-607 pubmed..Our data argue against a universal role of PTCs in regulating pre-mRNA splicing and reveal an additional function of SR proteins in eukaryotic gene expression. ..
- Zhu X, Park T, Winawer J, Wallman J. In a matter of minutes, the eye can know which way to grow. Invest Ophthalmol Vis Sci. 2005;46:2238-41 pubmed..Because the refractive status changes little during the period of lens wear, the authors conclude that eyes can rapidly determine the sign of the imposed blur without resorting to a trial-and-error method. ..
- Bandyopadhyay P, Liu S, Gabbai C, Venitelli Z, Steinman H. Environmental mimics and the Lvh type IVA secretion system contribute to virulence-related phenotypes of Legionella pneumophila. Infect Immun. 2007;75:723-35 pubmed..Since environmental amoebae are implicated as reservoirs for an increasing number of environmental pathogens and for drug-resistant bacteria, the environmental mimics developed here may be useful in virulence studies of other pathogens. ..
- Agate R, Hertel M, Nottebohm F. FnTm2, a novel brain-specific transcript, is dynamically expressed in the song learning circuit of the zebra finch. J Comp Neurol. 2007;504:127-48 pubmed..quot; We suggest that FnTm2 may be sensitive to affective and/or attentional states and thus may provide insights on how social variables influence the production and discrimination of learned vocalizations. ..
- Komatsu M, Wang Q, Holstein G, Friedrich V, Iwata J, Kominami E, et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A. 2007;104:14489-94 pubmed..Our study implicates impairment of axonal autophagy as a possible mechanism for axonopathy associated with neurodegeneration. ..
- Holinka C, Diczfalusy E, Coelingh Bennink H. Estetrol: a unique steroid in human pregnancy. J Steroid Biochem Mol Biol. 2008;110:138-43 pubmed publisher..This review is intended to offer an historical account of the discovery of E(4) and the preclinical studies conducted during the heyday of E(4) research that ended in the mid-1980s. ..
- Li W, Baker N. The active role of corpse engulfment pathways during cell competition. Fly (Austin). 2007;1:274-8 pubmed..We also speculate about how cell interactions at clone boundaries may initiate cell competition. ..
- Reitz C, Mayeux R. Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia. J Alzheimers Dis. 2010;19:229-51 pubmed publisher..In addition, we discuss the potentials and difficulties researchers face in designing appropriate studies for gene discovery. ..
- Krüger B, Yin N, Zhang N, Yadav A, Coward W, Lal G, et al. Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation. Eur J Immunol. 2010;40:2914-24 pubmed publisher..Subsequent downstream signaling results in intra-islet inflammation followed by T-cell-mediated graft destruction. ..
- Ndao M, Keene E, Amos F, Rewari G, Ponce C, ESTROFF L, et al. Intrinsically disordered mollusk shell prismatic protein that modulates calcium carbonate crystal growth. Biomacromolecules. 2010;11:2539-44 pubmed publisher..In conclusion, Asprich "3" possesses in vitro functional and structural qualities that are similar to other reported for other Asprich protein sequences. ..
- Lane R, Raines S, Steele J, Ehrlich M, Lah J, Small S, et al. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci. 2010;30:13110-5 pubmed publisher..003) in the brains of female Sorcs1 hypomorphic mice. From these data, we propose that dysfunction of SorCS1 may contribute to both the APP/A? disturbance underlying AD and the insulin/glucose disturbance underlying DM. ..
- Ouyang J, Parakhia R, Ochs R. Metformin activates AMP kinase through inhibition of AMP deaminase. J Biol Chem. 2011;286:1-11 pubmed publisher..Both metformin and the AMPD inhibitor suppressed ammonia accumulation by the cells. Knockdown of AMPD obviated metformin stimulation of glucose transport. We conclude that AMPD inhibition is the mechanism of metformin action. ..
- Lu S, Kappel L, Charbonneau Allard A, Atallah R, Holland A, Turbide C, et al. Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation. PLoS ONE. 2011;6:e21611 pubmed publisher..Because of its expression on both the donor graft and host tissues, this suggests that targeting Ceacam1 may represent a potent strategy for the regulation of GVHD and GVT after allogeneic transplantation. ..
- Montrose D, Zhou X, Kopelovich L, Yantiss R, Karoly E, Subbaramaiah K, et al. Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia. Cancer Prev Res (Phila). 2012;5:1358-67 pubmed publisher..Collectively, these results provide evidence that metabolomics can be used to detect changes in feces and plasma during azoxymethane-induced colorectal carcinogenesis and thus provide a strong rationale for future studies in humans. ..
- Pointer E, REISMAN R, Windham R, Murray L. Starvation and the clinicopathologic abnormalities associated with starved dogs: a review of 152 cases. J Am Anim Hosp Assoc. 2013;49:101-7 pubmed publisher..Although there was some evidence that dogs with anemia and/or hypoalbuminemia required more days to gain weight, future studies are required for confirmation. ..
- Romer A, Singh J, Rattan S, Krauss R. Smooth muscle fascicular reorientation is required for esophageal morphogenesis and dependent on Cdo. J Cell Biol. 2013;201:309-23 pubmed publisher..Collectively, these results illuminate mechanisms of esophageal morphogenesis and motility disorders. ..
- Asante C, Martin J. Differential joint-specific corticospinal tract projections within the cervical enlargement. PLoS ONE. 2013;8:e74454 pubmed publisher..Our findings show a surprising fractionation of CST terminations in the caudal cervical enlargement that may be organized to engage different spinal premotor circuits for distal and proximal joint control. ..
- DiLillo D, Tan G, Palese P, Ravetch J. Broadly neutralizing hemagglutinin stalk-specific antibodies require Fc?R interactions for protection against influenza virus in vivo. Nat Med. 2014;20:143-51 pubmed publisher..These findings reveal a previously uncharacterized property of bNAbs and guide an approach toward enhancing mAb-mediated antiviral therapeutics. ..
- Serov A, Salafia C, Grebenkov D, Filoche M. The role of morphology in mathematical models of placental gas exchange. J Appl Physiol (1985). 2016;120:17-28 pubmed publisher..Advantages and shortcomings of various classes of models are discussed, and experimental techniques that may be used for model validation are summarized. Several directions for future development are suggested. ..
- Schenker E, Kohanski R. The native alpha 2 beta 2 tetramer is the only subunit structure of the insulin receptor in intact cells and purified receptor preparations. Arch Biochem Biophys. 1991;290:79-85 pubmed..We conclude that the alpha 2 beta 2 tetramer is the only insulin receptor subunit structure native in intact cells and subsequently isolated from cell membranes. ..
- Sparrow J, Barnstable C. A gradient molecule in developing rat retina: expression of 9-O-acetyl GD3 in relation to cell type, developmental age, and GD3 ganglioside. J Neurosci Res. 1988;21:398-409 pubmed..abstract truncated at 400 words) ..
- Chien C, Liem R. Characterization of the mouse gene encoding the neuronal intermediate filament protein alpha-internexin. Gene. 1994;149:289-92 pubmed..However, the tail domains show significant differences which may make it possible to raise specific antibodies that can distinguish the alpha INX of mouse from that of rat. ..
- Shan W, Tanaka H, Phillips G, Arndt K, Yoshida M, Colman D, et al. Functional cis-heterodimers of N- and R-cadherins. J Cell Biol. 2000;148:579-90 pubmed..The present study provides a novel paradigm for cadherin interaction whereby selective cis-heterodimer formation may generate new functional units to mediate cell-cell adhesion. ..
- Gardner T, Cecchi G, Magnasco M, Laje R, Mindlin G. Simple motor gestures for birdsongs. Phys Rev Lett. 2001;87:208101 pubmed..stops, and pauses between syllables, as well as variation in pitch and timbre are inherent in the mechanics and can often be expressed through smooth and simple variations in the frequency and relative phase of two driving parameters..
- Zhang D, Yu W, Geisbrecht B, Gould S, Sprecher H, Schulz H. Functional characterization of Delta3,Delta2-enoyl-CoA isomerases from rat liver. J Biol Chem. 2002;277:9127-32 pubmed..In peroxisomes, ECI is predicted to be the dominant enzyme for the 3-cis --> 2-trans and 3-trans --> 2-trans isomerizations of long-chain intermediates, whereas MFE1 is the key enzyme in the 2,5 --> 3,5 isomerization. ..
- Glass M, Pickel V. Alpha(2A)-adrenergic receptors are present in mu-opioid receptor containing neurons in rat medial nucleus tractus solitarius. Synapse. 2002;43:208-18 pubmed
- Zhang Y, Chalfie M. MTD-1, a touch-cell-specific membrane protein with a subtle effect on touch sensitivity. Mech Dev. 2002;119:3-7 pubmed..Neither mtd-1 RNAi nor a putative mtd-1 loss-of-function mutation resulted in touch insensitivity, but both enhanced the touch insensitivity of mec-6(u247), a temperature sensitive allele, at the permissive temperature. ..
- Corti R, Badimon J, Mizsei G, Macaluso F, Lee M, Licato P, et al. Real time magnetic resonance guided endomyocardial local delivery. Heart. 2005;91:348-53 pubmed..The use of this real time catheter tracking may enable precise and adequate delivery of agents for tissue regeneration. ..
- Jechlinger M, Podsypanina K, Varmus H. Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Genes Dev. 2009;23:1677-88 pubmed publisher..Moreover, cells in the surviving spheres retain the ability to respond to reinduction and thus may represent the type of cells that give rise to recurrent tumors. ..
- Dietz K, CASACCIA P. HDAC inhibitors and neurodegeneration: at the edge between protection and damage. Pharmacol Res. 2010;62:11-7 pubmed publisher..This review article addresses how opposing effects on distinct cell types may profoundly influence the overall therapeutic potential of HDAC inhibitors when investigating treatments for neurodegenerative disorders. ..
- Butkus M, Hughes K, Bowman D, Liotta J, Jenkins M, Labare M. Inactivation of Ascaris suum by short-chain fatty acids. Appl Environ Microbiol. 2011;77:363-6 pubmed publisher..Predictions from an inhibition model (50% inhibitory concentration [IC(50)]) based on quantitative structure-activity relationships were congruent with inactivation data...
- Ewald C, Li C. Caenorhabditis elegans as a model organism to study APP function. Exp Brain Res. 2012;217:397-411 pubmed publisher..elegans are also reviewed. The C. elegans system provides a powerful genetic model to identify genes regulating the molecular mechanisms underlying intracellular ?-amyloid peptide accumulation. ..
- Flavell S, Pokala N, Macosko E, Albrecht D, Larsch J, Bargmann C. Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans. Cell. 2013;154:1023-1035 pubmed publisher..The slow temporal dynamics of this neuromodulatory circuit supplement fast motor circuits to organize long-lasting behavioral states. ..
- Iigaya K, Fusi S. Dynamical regimes in neural network models of matching behavior. Neural Comput. 2013;25:3093-112 pubmed publisher..Because our model provides a link between synaptic dynamics and qualitatively different behaviors, this work provides us with insight into the effects of neuromodulators on adaptive behaviors and psychiatric disorders. ..
- Jamal Uddin M, Joe Y, Kim S, Oh Jeong S, Ryter S, Pae H, et al. IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production. Cell Mol Immunol. 2016;13:170-9 pubmed publisher..In conclusion, CO and HO-1 induction regulates IRG1 and A20 expression, leading to inhibition of inflammation in vitro and in an in vivo mice model. ..
- Jones K, Ruscetti S, Lilly F. Loss of pathogenicity of spleen focus-forming virus after pseudotyping with Akv. J Virol. 1988;62:511-8 pubmed..Thus, the helper virus used to rescue SFFV plays at least a quantitatively important role in the early stage of FV disease and a crucial role in the late stage of the disease in vivo...
- Papatsenko D, Sheng G, Desplan C. A new rhodopsin in R8 photoreceptors of Drosophila: evidence for coordinate expression with Rh3 in R7 cells. Development. 1997;124:1665-73 pubmed..Consistent with this, rh5 expression in R8 disappears when R7 cells are absent (in sevenless mutant). We propose a model for the concerted evolution of opsin genes and the elaboration of the architecture of the retina. ..
- Vosshall L, Amrein H, Morozov P, Rzhetsky A, Axel R. A spatial map of olfactory receptor expression in the Drosophila antenna. Cell. 1999;96:725-36 pubmed..The isolation of candidate odorant receptor genes along with a genetic analysis of olfactory-driven behavior in insects may ultimately afford a system to understand the mechanistic link between odor recognition and behavior. ..
- Kim U, Gunther C, Roeder R. Genetic analyses of NFKB1 and OCA-B function: defects in B cells, serum IgM level, and antibody responses in Nfkb1-/-Oca-b-/- mice. J Immunol. 2000;165:6825-32 pubmed..These results suggest that NFKB1 and OCA-B play compensatory roles in multiple aspects of B cell differentiation. ..
- Saito S, Nishimura H, Phelps R, Wolf I, Suzuki M, Honjo T, et al. Induction of skin fibrosis in mice expressing a mutated fibrillin-1 gene. Mol Med. 2000;6:825-36 pubmed..The results suggest that, although cutaneous hyperplasia is due to mutated Fbn-1 gene, the TSK syndrome may be multifactorial. ..
- Radoja N, Stojadinovic O, Waseem A, Tomic Canic M, Milisavljevic V, Teebor S, et al. Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription. Mol Cell Biol. 2004;24:3168-79 pubmed..Using these agents, we could boost the amounts of K15 in human epidermis. Our findings suggest that treatments based on thyroid hormone and IFN-gamma could become effective agents in therapy for patients with EBS. ..
- Vitale A, Perlin J, Leonelli L, Herr J, Wright P, Digilio L, et al. Mouse cPLA2gamma, a novel oocyte and early embryo-abundant phospholipase A2 gamma-like protein, is targeted to the nuclear envelope during germinal vesicle breakdown. Dev Biol. 2005;282:374-84 pubmed..Furthermore, mouse cPLA2gamma protein continues to be expressed in the embryo until the 4-8-cell stage of development, suggesting that mouse cPLA2gamma may function as a previously uncharacterized maternal effect gene. ..
- Hanss B, Leal Pinto E, Teixeira A, Tran B, Lee C, Henderson S, et al. Localization of the nucleic acid channel regulatory subunit, cytosolic malate dehydrogenase. J Membr Biol. 2008;226:1-8 pubmed publisher..Both immunofluorescence and immunoelectron microscopy demonstrated cMDH at the plasma membrane of LLC-PK(1) cells. This finding supports prior functional data that describe a role for cMDH as the regulatory subunit of NACh. ..
- Shan J, Betzenhauser M, Kushnir A, Reiken S, Meli A, Wronska A, et al. Role of chronic ryanodine receptor phosphorylation in heart failure and ?-adrenergic receptor blockade in mice. J Clin Invest. 2010;120:4375-87 pubmed publisher..Thus, chronic PKA hyperphosphorylation of RyR2 results in a diastolic leak that causes cardiac dysfunction. Reversing PKA hyperphosphorylation of RyR2 is an important mechanism underlying the therapeutic action of ?-blocker therapy in HF...
- Kon N, Zhong J, Qiang L, Accili D, Gu W. Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem. 2012;287:5102-11 pubmed publisher..These findings underscore an important role of ARF-BP1 in maintaining ?-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo. ..
- Chen H, Edwards R, Tucci S, Bu P, Milsom J, Lee S, et al. Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. J Clin Invest. 2012;122:3184-96 pubmed publisher..Overall, these data indicate that CCL25 and CCR9 regulate CRC progression and invasion and further demonstrate an appropriate in vivo experimental system to study CRC progression in the native colon microenvironment. ..
- Xiao Y, Lucas B, Molcho E, Vigodner M. Cross-talk between sumoylation and phosphorylation in mouse spermatocytes. Biochem Biophys Res Commun. 2017;487:640-645 pubmed publisher..Both the AURKs and PLK1 appear to be "at the right place, at the right time" to at least, in part, explain the meiotic arrest obtained in the spermatocyte culture. ..
- Harrington J, Sorabella R, Tercek A, Isler J, TARGOFF K. Nkx2.5 is essential to establish normal heart rate variability in the zebrafish embryo. Am J Physiol Regul Integr Comp Physiol. 2017;313:R265-R271 pubmed publisher..5 in maintaining normal heart rate and HRV during early conduction system development. ..
- King M, Bradshaw S, Chang A, Pintar J, Pasternak G. Potentiation of opioid analgesia in dopamine2 receptor knock-out mice: evidence for a tonically active anti-opioid system. J Neurosci. 2001;21:7788-92 pubmed..Thus, dopamine D(2) receptors represent an additional, significant modulatory system that inhibits analgesic responses to mu and kappa opioids. ..
- Garrett S, Varney K, Weber D, Bresnick A. S100A4, a mediator of metastasis. J Biol Chem. 2006;281:677-80 pubmed
- Seandel M, James D, Shmelkov S, Falciatori I, Kim J, Chavala S, et al. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 2007;449:346-50 pubmed
- Dasen J, De Camilli A, Wang B, Tucker P, Jessell T. Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1. Cell. 2008;134:304-16 pubmed publisher..Our findings show that FoxP1 is a crucial determinant of motor neuron diversification and connectivity, and clarify how this Hox regulatory network controls the formation of a topographic neural map. ..
- Pollard J. Role of colony-stimulating factor-1 in reproduction and development. Mol Reprod Dev. 1997;46:54-60; discussion 60-1 pubmed..The pleiotropic roles for CSF-1 in reproduction and in the brain suggest that CSF-1 exerts many of its action through the trophic activities of cells of the mononuclear phagocytic lineage. ..
- Amin A, Patel R, Thakker G, Lowenstein C, Attur M, Abramson S. Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines. FEBS Lett. 1997;410:259-64 pubmed..This property of tetracyclines may have beneficial effects in the treatment of various diseases where excess nitric oxide has been implicated in the pathophysiology of these diseases. ..
- Jacobs Cohen R, Wade P, Gershon M. Suppression of the melanogenic potential of migrating neural crest-derived cells by the branchial arches. Anat Rec. 2002;268:16-26 pubmed..These observations suggest that a factor(s) that is normally expressed in the branchial arches, and is lacking in animals with the Silky mutation, prevents cells with a melanogenic potential from colonizing the bowel. ..
- Bruhns P, Samuelsson A, Pollard J, Ravetch J. Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease. Immunity. 2003;18:573-81 pubmed
- Aleynik S, Lieber C. Polyenylphosphatidylcholine corrects the alcohol-induced hepatic oxidative stress by restoring s-adenosylmethionine. Alcohol Alcohol. 2003;38:208-12 pubmed
- Faust P. Abnormal cerebellar histogenesis in PEX2 Zellweger mice reflects multiple neuronal defects induced by peroxisome deficiency. J Comp Neurol. 2003;461:394-413 pubmed
- Elbert M, Cohen D, Müsch A. PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells. Mol Biol Cell. 2006;17:3345-55 pubmed..Instead, our data suggest that both proteins function antagonistically to regulate the assembly of functional E-cadherin-dependent adhesion complexes. ..
- Chen Z, Jing D, Bath K, Ieraci A, Khan T, Siao C, et al. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science. 2006;314:140-3 pubmed..A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders. ..
- Balaji J, Ryan T. Single-vesicle imaging reveals that synaptic vesicle exocytosis and endocytosis are coupled by a single stochastic mode. Proc Natl Acad Sci U S A. 2007;104:20576-81 pubmed..We propose that evidence for fast endocytosis, such as that proposed to support the presence of kiss-and-run, is likely explained by the stochastic nature of a slower process. ..
- Azeloglu E, Bhattacharya J, Costa K. Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness. J Appl Physiol (1985). 2008;105:652-61 pubmed publisher..These findings partially explain reported heterogeneity of alveolar cell deformation during in situ lung inflation and provide needed data for better understanding of how mechanical stretch influences surfactant release. ..
- Hoffmann H, Palese P, Shaw M. Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity. Antiviral Res. 2008;80:124-34 pubmed publisher..Furthermore, we raise the possibility that compounds that result in increased viral titers may be beneficial for boosting the production of tissue culture-grown influenza vaccines. ..
- Chen Q, Yang W, Gupta S, Biswas P, Smith P, Bhagat G, et al. IRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor. Immunity. 2008;29:899-911 pubmed publisher..Thus, IBP appears to be important in preventing T cell-mediated autoimmunity by ensuring that the production of IL-17 and IL-21 does not occur in response to self-antigens. ..
- Argaw A, Gurfein B, Zhang Y, Zameer A, John G. VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc Natl Acad Sci U S A. 2009;106:1977-82 pubmed publisher..Previous studies have shown CLN-5 to be a key determinant of trans-endothelial resistance at the BBB. Our findings suggest that its down-regulation by VEGF-A constitutes a significant mechanism in BBB breakdown. ..
- Ozcivici E, Luu Y, Adler B, Qin Y, Rubin J, Judex S, et al. Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol. 2010;6:50-9 pubmed publisher..Mechanical targeting of the bone marrow stem-cell pool might, therefore, represent a novel, drug-free means of slowing the age-related decline of the musculoskeletal system. ..
- Albrecht D, Bargmann C. High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments. Nat Methods. 2011;8:599-605 pubmed publisher..The devices are inexpensive, easy to fabricate, reusable and suitable for delivering any liquid-borne stimulus. ..
- del Valle Rodriguez A, Didiano D, Desplan C. Power tools for gene expression and clonal analysis in Drosophila. Nat Methods. 2011;9:47-55 pubmed publisher..Our intention is to provide guidance and suggestions regarding which genetic tools are most suitable for addressing different developmental questions. ..
- Pilny A, Quesenberry K, Bartick Sedrish T, Latimer K, Berghaus R. Evaluation of Chlamydophila psittaci infection and other risk factors for atherosclerosis in pet psittacine birds. J Am Vet Med Assoc. 2012;240:1474-80 pubmed publisher..To determine whether the presence of Chlamydophila psittaci antigen, plasma cholesterol concentration, diet, sex, species, and age are risk factors for the development of atherosclerosis in pet psittacine birds...
- Gong B, Pan Y, Zhao W, Knable L, Vempati P, Begum S, et al. IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway. Mol Immunol. 2013;56:619-29 pubmed publisher..IVIG may systematically improve cognitive function in AD brain by passing A? toxicity. ..
- Stimpson C, Barger N, Taglialatela J, Gendron Fitzpatrick A, Hof P, Hopkins W, et al. Differential serotonergic innervation of the amygdala in bonobos and chimpanzees. Soc Cogn Affect Neurosci. 2016;11:413-22 pubmed publisher..These findings suggest that variation in serotonergic innervation of the amygdala may contribute to mediating the remarkable differences in social behavior exhibited by bonobos and chimpanzees. ..
- Geiger T, Sun J. Development and maturation of natural killer cells. Curr Opin Immunol. 2016;39:82-9 pubmed publisher..Here we will review our current understanding of the molecular mechanisms driving development of NK cells from the common lymphoid progenitor (CLP) to mature NK cells, and from activated effectors to long-lived memory NK cells. ..
- Philip M, Fairchild L, Sun L, Horste E, Camara S, Shakiba M, et al. Chromatin states define tumour-specific T cell dysfunction and reprogramming. Nature. 2017;545:452-456 pubmed publisher..Our study has important implications for cancer immunotherapy as we define key transcription factors and epigenetic programs underlying T cell dysfunction and surface markers that predict therapeutic reprogrammability. ..
- House J, House C, Llewellyn M. Characteristics of the porcine kidney cell line IB-RS-2 clone D10 (IB-RS-2 D10) which is free of hog cholera virus. In Vitro Cell Dev Biol. 1988;24:677-82 pubmed..The IB-RS-2 D10 cells had a median chromosome count of 34, were morphologically epithelioid cells, and were resistant to HCV infection. Freedom from HCV affords advantages for vaccine production and avoids laboratory contamination. ..
- Han J, Baker N, Rubin C. Molecular characterization of a novel A kinase anchor protein from Drosophila melanogaster. J Biol Chem. 1997;272:26611-9 pubmed..The DAKAP550 gene was mapped to the 4F1.2 region of the X chromosome; flies that carry a deletion for this portion of the X chromosome lack DAKAP550 protein. ..
- Mailhos C, Andre S, Mollereau B, Goriely A, Hemmati Brivanlou A, Desplan C. Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators. Development. 1998;125:937-47 pubmed..Interactive repression may represent specific interactions among Prd-class homeoproteins, several of which act early during development of invertebrate and vertebrate embryos. ..
- Wang F, Nemes A, Mendelsohn M, Axel R. Odorant receptors govern the formation of a precise topographic map. Cell. 1998;93:47-60 pubmed..These data, along with additional receptor substitutions, indicate that the odorant receptor plays an instructive role in the establishment of the topographic map. ..
- Chang C, Hemmati Brivanlou A. Cell fate determination in embryonic ectoderm. J Neurobiol. 1998;36:128-51 pubmed..Emphasis is placed on, but not limited to, discoveries made in Xenopus, as most of our progress in understanding the ectodermal patterning is obtained from studies using this organism. ..
- Thompson J, Begenisich T. Interaction between quaternary ammonium ions in the pore of potassium channels. Evidence against an electrostatic repulsion mechanism. J Gen Physiol. 2000;115:769-82 pubmed..We found that these results can be simulated by a simple 4-barrier-3-site permeation model in which ions compete for available binding sites without long-range electrostatic interactions...
- Streit A, Berliner A, Papanayotou C, Sirulnik A, Stern C. Initiation of neural induction by FGF signalling before gastrulation. Nature. 2000;406:74-8 pubmed..We show that the organizer and some of its precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction...
- Bouzahzah B, Fu M, Iavarone A, Factor V, Thorgeirsson S, Pestell R. Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo. Cancer Res. 2000;60:4531-7 pubmed..TGF-beta1 regulation of HDAC1/pocket protein associations may provide a link between chromatin remodeling proteins and cdk inhibition through induction of cdc25A in vivo. ..
- Mari M, Wu D, Nieto N, Cederbaum A. CYP2E1-dependent toxicity and up-regulation of antioxidant genes. J Biomed Sci. 2001;8:52-8 pubmed..Such interactions between CYP2E1, mitochondria and altered GSH homeostasis, and elevation of collagen levels, may play a role in alcohol-induced liver injury. ..
- Ruscito B, Harrison N. Hemoglobin metabolites mimic benzodiazepines and are possible mediators of hepatic encephalopathy. Blood. 2003;102:1525-8 pubmed..The accumulation of these porphyrins under pathophysiologic conditions provides a potentially novel mechanism for the central manifestations of HE. ..
- Loonam T, Noailles P, Yu J, Zhu J, Angulo J. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum. Life Sci. 2003;73:727-39 pubmed..Neuropeptide receptors represent an important control point mediating the effects of the neurotransmitter DA in the striatum of the rodent brain. ..
- Hatcher C, Diman N, Kim M, Pennisi D, Song Y, Goldstein M, et al. A role for Tbx5 in proepicardial cell migration during cardiogenesis. Physiol Genomics. 2004;18:129-40 pubmed..Therefore, we propose that Tbx5 participates in regulation of proepicardial cell migration, a critical event in the establishment of the epicardium and coronary vasculature. ..
- Tepper O, Callaghan M, Chang E, Galiano R, Bhatt K, Baharestani S, et al. Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. FASEB J. 2004;18:1231-3 pubmed..These findings suggest a potential role for PEMF in therapeutic angiogenesis. ..