Genomes and Genes
Experts and Doctors on molecular sequence data in Warsaw, Masovian Voivodeship, Poland
Locale: Warsaw, Masovian Voivodeship, Poland
Topic: molecular sequence data
- Zagulski M, Kressler D, Becam A, Rytka J, Herbert C. Mak5p, which is required for the maintenance of the M1 dsRNA virus, is encoded by the yeast ORF YBR142w and is involved in the biogenesis of the 60S subunit of the ribosome. Mol Genet Genomics. 2003;270:216-24 pubmed..8S rRNAs. Thus, Mak5p is involved in the biogenesis of 60S ribosomal subunits. ..
- Bartosik D, Baj J, Bartosik A, Wlodarczyk M. Characterization of the replicator region of megaplasmid pTAV3 of Paracoccus versutus and search for plasmid-encoded traits. Microbiology. 2002;148:871-81 pubmed..Using pORI6, it was demonstrated that replication systems related to pTAV3 are also present in the replicons of Paracoccus alcaliphilus JCM 7364, Paracoccus thiocyanatus IAM 12816 and Paracoccus methylutens DM 12...
- Knizewski L, Kinch L, Grishin N, Rychlewski L, Ginalski K. Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families with modified transitive meta profile searches. BMC Struct Biol. 2007;7:40 pubmed..Further experimental investigations should address the predicted activity and clarify potential substrates providing further insight into detailed biological role of these newly detected nucleases. ..
- Bujnicki J, Albert M, Nelson D, Thurlow D. Fold recognition, homology modeling, docking simulations, kinetics analysis and mutagenesis of ATP/CTP:tRNA nucleotidyltransferase from Methanococcus jannaschii. Proteins. 2003;52:349-59 pubmed..Our results suggest a mechanism of differential ATP and CTP binding, which explains how the tRNA NTase, having only one catalytic site, utilizes different nucleotide triphosphates depending on the nature of the tRNA substrate. ..
- Kupniewska Kozak A, Gospodarska E, Dadlez M. Intertwined structured and unstructured regions of exRAGE identified by monitoring hydrogen-deuterium exchange. J Mol Biol. 2010;403:52-65 pubmed publisher..The highlight of the present study is the contrasting behavior of the different regions of the protein, with the protected regions neighboring fully exposed parts especially in the N-terminal V domain...
- Trzcinska Daneluti A, Górecki A, Czubaty A, Kowalska Loth B, Girstun A, Murawska M, et al. RRM proteins interacting with the cap region of topoisomerase I. J Mol Biol. 2007;369:1098-112 pubmed..Together with the previously described inhibitory effect of RRM domains of SF2/ASF on DNA cleavage, the above suggests that the binding of RRM proteins could regulate the activity of topoisomerase I. ..
- Giska F, Lichocka M, Piechocki M, Dadlez M, Schmelzer E, Hennig J, et al. Phosphorylation of HopQ1, a type III effector from Pseudomonas syringae, creates a binding site for host 14-3-3 proteins. Plant Physiol. 2013;161:2049-61 pubmed publisher..In addition, the mutated HopQ1 protein showed reduced stability in planta. These data suggest that the association between host 14-3-3 proteins and HopQ1 is important for modulating the properties of this bacterial effector. ..
- Lebska M, Szczegielniak J, Dobrowolska G, Cozza G, Moro S, Muszy ska G. A novel splicing variant encoding putative catalytic alpha subunit of maize protein kinase CK2. Physiol Plant. 2009;136:251-63 pubmed publisher..Preliminary results suggest that ZmCK2alpha-4 may function as a negative regulator of other CK2s, and at certain circumstances as a holoenzyme which catalytic activity is stimulated by specific regulatory subunit(s)...
- Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). J Mol Evol. 2004;59:204-217 pubmed publisher..Based on genome searches and EST analyses, the mouse and human genomes do not harbor GCAP4-8 or GCIP genes. ..
- Sokolowska M, Kaus Drobek M, Czapinska H, Tamulaitis G, Szczepanowski R, Urbanke C, et al. Monomeric restriction endonuclease BcnI in the apo form and in an asymmetric complex with target DNA. J Mol Biol. 2007;369:722-34 pubmed..As expected, BcnI is structurally similar to MvaI and recognizes conserved bases in the target sequence similarly but not identically. BcnI has a unique machinery for the recognition of the central base-pair. ..
- Lawrynowicz Paciorek M, Kochman M, Piekarska K, Grochowska A, Windyga B. The distribution of enterotoxin and enterotoxin-like genes in Staphylococcus aureus strains isolated from nasal carriers and food samples. Int J Food Microbiol. 2007;117:319-23 pubmed..Only three of all sea-sed positive strains had silent genes--sed. ..
- Bartosik D, Putyrski M, Dziewit L, Malewska E, Szymanik M, Jagiello E, et al. Transposable modules generated by a single copy of insertion sequence ISPme1 and their influence on structure and evolution of natural plasmids of Paracoccus methylutens DM12. J Bacteriol. 2008;190:3306-13 pubmed publisher..This illustrates that TMos may play a significant role in shaping the structure of natural plasmids, which consequently may have a great impact on the evolution of plasmid genomes...
- Trzcińska A, Girstun A, Piekiełko A, Kowalska Loth B, Staron K. Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display. Mol Biol Rep. 2002;29:347-52 pubmed..Four of identified proteins: Bub3 protein, Cockayne syndrome protein A, damaged DNA binding protein 2 and GRWD protein belong to WD-repeat proteins and their sequences recognized by the N-terminal domain are identically localized. ..
- Ciesla J, Weiner K, Weiner R, Reston J, Maley G, Maley F. Isolation and expression of rat thymidylate synthase cDNA: phylogenetic comparison with human and mouse thymidylate synthases. Biochim Biophys Acta. 1995;1261:233-42 pubmed..The TS level in the resistant cell line was 60 to 70-fold higher than normal which was found to be associated with both multiple gene copies and an expanded TS mRNA pool. ..
- Kurowska M, Rudnicka W, Kontny E, Janicka I, Chorazy M, Kowalczewski J, et al. Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. J Immunol. 2002;169:1760-7 pubmed..Thus, we have demonstrated that a distinctive phenotype of RA FLS, i.e., persistent activation, proliferation, and resistance to apoptosis, is related to the autocrine activation of IL-15Rs by FLS-derived IL-15. ..
- Jaszczur M, Flis K, Rudzka J, Kraszewska J, Budd M, Polaczek P, et al. Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae. Genetics. 2008;178:633-47 pubmed publisher..Our results show that DNA polymerase subunits other than those housing the DNA polymerase and 3' --> 5' exonuclease are essential in controlling the level of spontaneous mutagenesis and genetic stability in yeast cells. ..
- Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N, et al. Weak binding affinity of human 4EHP for mRNA cap analogs. RNA. 2007;13:691-7 pubmed..We show that 4EHP binds cap analogs m(7)GpppG and m(7)GTP with 30 and 100 lower affinity than eIF4E. Thus, 4EHP cannot compete with eIF4E for binding to the cap structure of most mRNAs. ..
- Kilanczyk E, Filipek S, Filipek A. ERK1/2 is dephosphorylated by a novel phosphatase--CacyBP/SIP. Biochem Biophys Res Commun. 2011;404:179-83 pubmed publisher..Our experimental results are supported by a theoretical analysis which revealed important sequence similarities between CacyBP/SIP and the phosphatase-like proteins as well as certain MAP kinase phosphatases. ..
- Chelstowska A, Zoladek T, Garey J, Kushner J, Rytka J, Labbe Bois R. Identification of amino acid changes affecting yeast uroporphyrinogen decarboxylase activity by sequence analysis of hem12 mutant alleles. Biochem J. 1992;288 ( Pt 3):753-7 pubmed..The results suggest that there is a single active centre in uroporphyrinogen decarboxylase, the geometry of which is affected in the mutant enzymes. ..
- Niedzwiecka A, Lekka M, Nilsson P, Virtanen A. Global architecture of human poly(A)-specific ribonuclease by atomic force microscopy in liquid and dynamic light scattering. Biophys Chem. 2011;158:141-9 pubmed publisher..We discuss a putative internal arrangement of three functional domains within the full length PARN dimer. ..
- Jankiewicz U, Brzezinska M, Saks E. Identification and characterization of a chitinase of Stenotrophomonas maltophilia, a bacterium that is antagonistic towards fungal phytopathogens. J Biosci Bioeng. 2012;113:30-5 pubmed publisher..The purified enzyme inhibited the growth of fungal phytopathogens belonging to the genera Fusarium, Rhizoctonia and Alternaria. ..
- Mikosa M, Sochacka Pietal M, Baj J, Bartosik D. Identification of a transposable genomic island of Paracoccus pantotrophus DSM 11072 by its transposition to a novel entrapment vector pMMB2. Microbiology. 2006;152:1063-73 pubmed
- Cieslak J, Pawlak P, Wodas L, Borowska A, Stachowiak A, Puppel K, et al. Characterization of equine CSN1S2 variants considering genetics, transcriptomics, and proteomics. J Dairy Sci. 2016;99:1277-1285 pubmed publisher..Our results provide insight into the equine CSN1S2 structure and lay a foundation for further functional analyses regarding, for example, allergenicity or physiochemical properties of the observed CSN1S2 variants. ..
- Tomecki R, Dmochowska A, Gewartowski K, Dziembowski A, Stepien P. Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase. Nucleic Acids Res. 2004;32:6001-14 pubmed
- Konopinski R, Nowak R, Siedlecki J. Cloning and characterization of the 5' part of the high molecular weight transcript of rat DNA polymerase beta. Acta Biochim Pol. 1995;42:253-8 pubmed..Because of that, alternative polyadenylation is discussed as a possible mechanism for tissue- and development-specific regulation of the DNA polymerase beta gene expression. ..
- Sirko A, Wegleńska A, Hryniewicz M, Hulanicka D. Characterization of the Escherichia coli gene encoding a new member of the short-chain dehydrogenase/reductase (SDR) family. Acta Biochim Pol. 1997;44:153-7 pubmed..Involvement of Crp, FruR and IHF in the regulation of ucpA transcription in vivo was demonstrated. ..
- Zagulski M, Nowak J, Le Mouël A, Nowacki M, Migdalski A, Gromadka R, et al. High coding density on the largest Paramecium tetraurelia somatic chromosome. Curr Biol. 2004;14:1397-404 pubmed..Extrapolation to the whole genome suggests that Paramecium has at least 30,000 genes...
- Trzemecka A, Jacewicz A, Carver G, Drake J, Bebenek A. Reversal of a mutator activity by a nearby fidelity-neutral substitution in the RB69 DNA polymerase binding pocket. J Mol Biol. 2010;404:778-93 pubmed publisher..An additional antimutagenic factor may be a structural alteration in the polymerase binding pocket described in this article. ..
- Ostrowski J, Wyrwicz L, Rychlewski L, Bomsztyk K. Heterogeneous nuclear ribonucleoprotein K protein associates with multiple mitochondrial transcripts within the organelle. J Biol Chem. 2002;277:6303-10 pubmed..Results of this study suggest that K protein acts within functional modules that are responsible for expression of genes in mitochondria. ..
- Pluta K, Lefebvre O, Martin N, Smagowicz W, Stanford D, Ellis S, et al. Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae. Mol Cell Biol. 2001;21:5031-40 pubmed..These results indicate that Maf1p acts as a negative effector of Pol III synthesis. This potential regulator of Pol III transcription is likely conserved since orthologs of Maf1p are present in other eukaryotes, including humans. ..
- Madej Pilarczyk A, Rosińska Borkowska D, Rekawek J, Marchel M, Szaluś E, Jabłońska S, et al. Progeroid syndrome with scleroderma-like skin changes associated with homozygous R435C LMNA mutation. Am J Med Genet A. 2009;149A:2387-92 pubmed publisher..Scleroderma-like skin changes in infants, associated with growth retardation and dysmorphic features, suggest premature aging syndrome, requiring genetic testing and counseling of asymptomatic carriers of LMNA mutations. ..
- Pliszka B, Redowicz M, Stepkowski D. Interaction of the N-terminal part of the A1 essential light chain with the myosin heavy chain. Biochem Biophys Res Commun. 2001;281:924-8 pubmed..Localization of residues which can possibly react with the cross-linker suggests that the interaction might involve the N-terminal residues of the A1 light chain and the converter region of the heavy chain. ..
- Brzeski J, Podstolski W, Olczak K, Jerzmanowski A. Identification and analysis of the Arabidopsis thaliana BSH gene, a member of the SNF5 gene family. Nucleic Acids Res. 1999;27:2393-9 pubmed
- Hoffman Sommer M, Grynberg M, Kucharczyk R, Rytka J. The CHiPS Domain--ancient traces for the Hermansky-Pudlak syndrome. Traffic. 2005;6:534-8 pubmed..Our results suggest that the cellular machinery involved in the HPS syndrome is ancient. ..
- Malkowska M, Kokoszynska K, Rychlewski L, Wyrwicz L. Structural bioinformatics of the general transcription factor TFIID. Biochimie. 2013;95:680-91 pubmed publisher..In this study we provided detailed structural models for all the elements of human analyzed in the context of TFIID activity, along with indications of structural alterations within TFIID in various animal model species. ..
- Grabowska A, Wisniewska A, Tagashira N, Malepszy S, Filipecki M. Characterization of CsSEF1 gene encoding putative CCCH-type zinc finger protein expressed during cucumber somatic embryogenesis. J Plant Physiol. 2009;166:310-23 pubmed publisher..As a result of transferring an antisense fragment of CsSEF1 into Arabidopsis thaliana abnormalities in zygotic embryos and also in cotyledons and root development were observed...
- Wypijewska A, Bojarska E, Lukaszewicz M, Stepinski J, Jemielity J, Davis R, et al. 7-methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity. Biochemistry. 2012;51:8003-13 pubmed publisher..Our data have important implications for the regulatory role of m(7)GDP in mRNA metabolic pathways due to its possible interactions with different cap-binding proteins, such as DcpS or eIF4E...
- Jaciuk M, Nowak E, Skowronek K, Tańska A, Nowotny M. Structure of UvrA nucleotide excision repair protein in complex with modified DNA. Nat Struct Mol Biol. 2011;18:191-7 pubmed publisher..The DNA region harboring the modification is deformed, with the double helix bent and unwound. UvrA uses damage-induced deformations of the DNA and a less rigid structure of the modified double helix for indirect readout of the lesion. ..
- Kurowska E, Bonna A, Goch G, Bal W. Salivary histatin-5, a physiologically relevant ligand for Ni(II) ions. J Inorg Biochem. 2011;105:1220-5 pubmed publisher..Therefore, Hst-5 and other histatins should be considered as factors in nickel allergy and other forms of nickel toxicity. ..
- Orlowski J, Mebrhatu M, Michiels C, Bujnicki J, Aertsen A. Mutational analysis and a structural model of methyl-directed restriction enzyme Mrr. Biochem Biophys Res Commun. 2008;377:862-6 pubmed publisher..The activity of a number of spontaneous and strategically constructed Mrr mutants is discussed in the light of this model, providing a first insight into the structure-function relationships of the Mrr enzyme. ..
- Zurawska A, Urbanski J, Bieganowski P. Hsp90n - An accidental product of a fortuitous chromosomal translocation rather than a regular Hsp90 family member of human proteome. Biochim Biophys Acta. 2008;1784:1844-6 pubmed publisher..We propose that Hsp90N was created as an artifact of a cDNA synthesis or that it is a chimeric protein, being a result of the chromosomal rearrangement that occurred in a single cell line, after this line was established. ..
- Bartosik D, Baj J, Sochacka M, Piechucka E, Wlodarczyk M. Molecular characterization of functional modules of plasmid pWKS1 of Paracoccus pantotrophus DSM 11072. Microbiology. 2002;148:2847-56 pubmed publisher..Plasmid pWKS1 could replicate in 10 species of Paracoccus and in Agrobacterium tumefaciens, Rhizobium leguminosarum and Rhodobacter sphaeroides, but it could not replicate in E. coli...
- Łobocka M, Rose D, Plunkett G, Rusin M, Samojedny A, Lehnherr H, et al. Genome of bacteriophage P1. J Bacteriol. 2004;186:7032-68 pubmed..The base content and distribution in P1 DNA indicate that replication of P1 from its plasmid origin had more impact on the base compositional asymmetries of the P1 genome than replication from the lytic origin of replication...
- Sarnowski T, Rios G, Jasik J, Swiezewski S, Kaczanowski S, Li Y, et al. SWI3 subunits of putative SWI/SNF chromatin-remodeling complexes play distinct roles during Arabidopsis development. Plant Cell. 2005;17:2454-72 pubmed
- Kawalec M, Gniadkowski M, Kedzierska J, Skotnicki A, Fiett J, Hryniewicz W. Selection of a teicoplanin-resistant Enterococcus faecium mutant during an outbreak caused by vancomycin-resistant enterococci with the vanB phenotype. J Clin Microbiol. 2001;39:4274-82 pubmed..Expression of the resistance genes vanH(B), -B, and -X(B) was constitutive in the mutant, and this phenomenon was responsible for its unusual phenotype. ..
- Bykowski T, van der Ploeg J, Iwanicka Nowicka R, Hryniewicz M. The switch from inorganic to organic sulphur assimilation in Escherichia coli: adenosine 5'-phosphosulphate (APS) as a signalling molecule for sulphate excess. Mol Microbiol. 2002;43:1347-58 pubmed..Our data comprise the first evidence that APS may act as the negative cofactor of the transcriptional regulator Cbl, and that APS, and not sulphate itself, serves as the signalling molecule for sulphate excess. ..
- Bujnicki J, Blumenthal R, Rychlewski L. Sequence analysis and structure prediction of 23S rRNA:m1G methyltransferases reveals a conserved core augmented with a putative Zn-binding domain in the N-terminus and family-specific elaborations in the C-terminus. J Mol Microbiol Biotechnol. 2002;4:93-9 pubmed
- Gniadkowski M, Schneider I, Jungwirth R, Hryniewicz W, Bauernfeind A. Ceftazidime-resistant Enterobacteriaceae isolates from three Polish hospitals: identification of three novel TEM- and SHV-5-type extended-spectrum beta-lactamases. Antimicrob Agents Chemother. 1998;42:514-20 pubmed..The new TEM derivatives probably document the already advanced microevolution of ESBLs ongoing in Polish hospitals, in a majority of which no monitoring of ESBL producers was performed before 1996...
- Bujnicki J, Rychlewski L. Grouping together highly diverged PD-(D/E)XK nucleases and identification of novel superfamily members using structure-guided alignment of sequence profiles. J Mol Microbiol Biotechnol. 2001;3:69-72 pubmed..The first superfamily-wide comparative analysis, not limited to nucleases of known structure, will guide cloning and characterization of novel enzymes and planning new experiments to better understand those already studied. ..
- Trzemecka A, Płochocka D, Bebenek A. Different behaviors in vivo of mutations in the beta hairpin loop of the DNA polymerases of the closely related phages T4 and RB69. J Mol Biol. 2009;389:797-807 pubmed publisher..We propose that their beta loops facilitate strand separation in both polymerases, while the residues that form the loop have low structural constraints. ..
- Zienkiewicz M, Ferenc A, Wasilewska W, Romanowska E. High light stimulates Deg1-dependent cleavage of the minor LHCII antenna proteins CP26 and CP29 and the PsbS protein in Arabidopsis thaliana. Planta. 2012;235:279-88 pubmed publisher..The interaction of Deg1 with the PsbS protein and the minor LHCII subunits implies its involvement in the regulation of both excess energy dissipation and state transition adaptation processes. ..
- Palczewska M, Groves P, Ambrus A, Kaleta A, Kover K, Batta G, et al. Structural and biochemical characterization of neuronal calretinin domain I-II (residues 1-100). Comparison to homologous calbindin D28k domain I-II (residues 1-93). Eur J Biochem. 2001;268:6229-37 pubmed..Despite close homology and similar secondary structures, CR I-II and Calb I-II probably have distinct tertiary structure features that suggest different cellular functions for the full-length proteins. ..
- Rychlik M, Chon H, Cerritelli S, Klimek P, Crouch R, Nowotny M. Crystal structures of RNase H2 in complex with nucleic acid reveal the mechanism of RNA-DNA junction recognition and cleavage. Mol Cell. 2010;40:658-70 pubmed publisher..Junction recognition is important for the removal of RNA embedded in DNA and may play an important role in DNA replication and repair. ..
- Koprowski P, Kubalski A. Bacterial ion channels and their eukaryotic homologues. Bioessays. 2001;23:1148-58 pubmed..The usefulness of bacterial mechanosensitive channels for the studies on general principles of mechanosensation is discussed. ..
- Pawłowski K, Muszewska A, Lenart A, Szczepińska T, Godzik A, Grynberg M. A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins. BMC Genomics. 2010;11:590 pubmed publisher..The new protein structural domain, now with a broad enzymatic function predicted, may become a drug target once its detailed molecular mechanism of action is understood in detail. ..
- Korza H, Bochtler M. Pseudomonas aeruginosa LD-carboxypeptidase, a serine peptidase with a Ser-His-Glu triad and a nucleophilic elbow. J Biol Chem. 2005;280:40802-12 pubmed publisher..We conclude that ld-carboxypeptidases are serine peptidases with Ser-His-Glu catalytic triads...
- Smyk A, Szuminska M, Uniewicz K, Graves L, Kozlowski P. Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth. FEBS J. 2006;273:4728-41 pubmed..Because PDIP46/SKAR is involved in the regulation of cell growth its interaction with ER may suggest some function for ER in that control. ..
- Wyroba E, Surmacz L, Osinska M, Wiejak J. Phagosome maturation in unicellular eukaryote Paramecium: the presence of RILP, Rab7 and LAMP-2 homologues. Eur J Histochem. 2007;51:163-72 pubmed..Immunoblotting confirmed presence of RILP-related polypeptide and a7 subunit of 26S proteasome in Paramecium protein fractions. These results suggest that Rab7, RILP and LAMP-2 may be involved in phagosome maturation in Paramecium...
- Berezowski V, Miecz D, Marszałek M, Bröer A, Broer S, Cecchelli R, et al. Involvement of OCTN2 and B0,+ in the transport of carnitine through an in vitro model of the blood-brain barrier. J Neurochem. 2004;91:860-72 pubmed..Expression of B(0,+) in BBCEC was confirmed by RT-PCR. These results suggest that OCTN2 and B(0,+) could be involved in carnitine transport in both the apical and basolateral membrane. ..
- Varabyova A, Topf U, Kwiatkowska P, Wrobel L, Kaus Drobek M, Chacinska A. Mia40 and MINOS act in parallel with Ccs1 in the biogenesis of mitochondrial Sod1. FEBS J. 2013;280:4943-59 pubmed publisher..Thus, we identified novel mitochondrial players that are possibly involved in pathological conditions caused by changes in the biogenesis of Sod1. ..
- Jacewicz A, Trzemecka A, Guja K, Plochocka D, Yakubovskaya E, Bebenek A, et al. A remote palm domain residue of RB69 DNA polymerase is critical for enzyme activity and influences the conformation of the active site. PLoS ONE. 2013;8:e76700 pubmed publisher..This represents a striking example of an action-at-a-distance interaction. ..
- Kwiatkowski B, Zielinska Kwiatkowska A, Migdalski A, Kleczkowski L, Wasilewska L. Cloning of two cDNAs encoding calnexin-like and calreticulin-like proteins from maize (Zea mays) leaves: identification of potential calcium-binding domains. Gene. 1995;165:219-22 pubmed..Motifs for retention in endoplasmic reticulum (Crl) and for an integral membrane-spanning sequence (Cln) have also been identified. ..
- Sirko A, Hryniewicz M, Hulanicka D, Bock A. Sulfate and thiosulfate transport in Escherichia coli K-12: nucleotide sequence and expression of the cysTWAM gene cluster. J Bacteriol. 1990;172:3351-7 pubmed..Expression of the four genes was analyzed in the T7 promoter-polymerase system. ..
- Hryniewicz M, Sirko A, Pałucha A, Bock A, Hulanicka D. Sulfate and thiosulfate transport in Escherichia coli K-12: identification of a gene encoding a novel protein involved in thiosulfate binding. J Bacteriol. 1990;172:3358-66 pubmed..Preliminary sequence data from the corresponding region of the Salmonella typhimurium chromosome showed strictly homologous counterparts of the E. coli cysP and cysT genes. ..
- Smorawinska M, Szuplewska M, Zaleski P, Wawrzyniak P, Maj A, Plucienniczak A, et al. Mobilizable narrow host range plasmids as natural suicide vectors enabling horizontal gene transfer among distantly related bacterial species. FEMS Microbiol Lett. 2012;326:76-82 pubmed publisher..g. resistance transposons) among evolutionarily distinct bacterial species. Thus, mobilizable NHR plasmids may play a much more important role in horizontal gene transfer than previously thought...
- Szczesny R, Borowski L, Brzezniak L, Dmochowska A, Gewartowski K, Bartnik E, et al. Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance. Nucleic Acids Res. 2010;38:279-98 pubmed publisher..Moreover, we present data indicating that hSuv3p co-purifies with PNPase; this may suggest participation of both proteins in mtRNA metabolism. ..
- Bujnicki J, Rychlewski L. Sequence analysis and structure prediction of aminoglycoside-resistance 16S rRNA:m7G methyltransferases. Acta Microbiol Pol. 2001;50:7-17 pubmed..Comparison of a three-dimensional model of the Agr family member with a recently solved structure of reovirus mRNA capping MTase suggests that the mechanism of guanine-N7 methylation in rRNA and mRNA may be different...
- Dziembowski A, Piwowarski J, Hoser R, Minczuk M, Dmochowska A, Siep M, et al. The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism. J Biol Chem. 2003;278:1603-11 pubmed..We suggest that the degradosome is a central part of a mitochondrial RNA surveillance system responsible for degradation of aberrant and unprocessed RNAs. ..
- Bandorowicz Pikula J, Kirilenko A, van Deursen R, Golczak M, Kühnel M, Lancelin J, et al. A putative consensus sequence for the nucleotide-binding site of annexin A6. Biochemistry. 2003;42:9137-46 pubmed
- Przybyl J, Sciot R, Rutkowski P, Siedlecki J, Vanspauwen V, Samson I, et al. Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases. Tumour Biol. 2012;33:2245-53 pubmed publisher..Furthermore, we describe the first case of a complex rearrangement possibly linking SS to REPS2 gene. ..
- Filipek A, Kuznicki J. Molecular cloning and expression of a mouse brain cDNA encoding a novel protein target of calcyclin. J Neurochem. 1998;70:1793-8 pubmed..Because CacyBP, like calcyclin, is present in the brain, the interaction of these two proteins might be involved in calcium signaling pathways in neuronal tissue. ..
- Gajda A, Towpik J, Steuerwald U, Müller C, Lefebvre O, Boguta M. Full repression of RNA polymerase III transcription requires interaction between two domains of its negative regulator Maf1. J Biol Chem. 2010;285:35719-27 pubmed publisher..These data relate Pol III transcription inhibition to Maf1 structural changes. ..
- Sadowy E, Sienko A, Gawryszewska I, Bojarska A, Malinowska K, Hryniewicz W. High abundance and diversity of antimicrobial resistance determinants among early vancomycin-resistant Enterococcus faecium in Poland. Eur J Clin Microbiol Infect Dis. 2013;32:1193-203 pubmed publisher..This analysis revealed the predominance of hospital-associated strains of E. faecium, carrying an abundant and divergent range of resistance determinants among early VREm isolates in Poland...
- Mielecki D, Saumaa S, Wrzesiński M, Maciejewska A, Zuchniewicz K, Sikora A, et al. Pseudomonas putida AlkA and AlkB proteins comprise different defense systems for the repair of alkylation damage to DNA - in vivo, in vitro, and in silico studies. PLoS ONE. 2013;8:e76198 pubmed publisher..It probably creates a backup system that protects P. putida strains defective in other DNA repair systems against alkylating agents of exo- and endogenous origin. ..
- Richter M, Poznanski J, Zdziarska A, Czarnocki Cieciura M, Lipinszki Z, Dadlez M, et al. Network of protein interactions within the Drosophila inner kinetochore. Open Biol. 2016;6:150238 pubmed publisher..Thus, we conclude the organization of the Mis12-Nnf1 dimer confers upon the Mis12 complex a bipolar, elongated structure that is critical for kinetochore function. ..